rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	51556	2	2	2	0	1	0	0	1	0	0	0.590	0.0885	1.000
2	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNGT1(1), HTR2C(1), PLCB1(8), TUB(2)	517190	12	9	10	7	2	1	0	3	6	0	0.904	0.216	1.000
3	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(2)	84242	3	3	3	3	0	1	0	1	1	0	0.943	0.586	1.000
4	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(2)	330026	3	3	2	1	0	0	2	1	0	0	0.645	0.659	1.000
5	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(1), ALDOC(1)	284076	2	2	2	0	1	1	0	0	0	0	0.470	0.754	1.000
6	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	120022	1	1	1	1	1	0	0	0	0	0	0.881	0.758	1.000
7	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	4	AOC2(2), AOC3(4), ESD(2)	360646	8	6	6	0	3	5	0	0	0	0	0.0373	0.760	1.000
8	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPL(2), ALPP(13), ALPPL2(5), FPGS(2), GCH1(1), GGH(3)	518717	26	12	18	8	6	9	3	7	1	0	0.204	0.768	1.000
9	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(2), AASS(2)	342070	4	4	4	2	0	2	0	1	1	0	0.861	0.787	1.000
10	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(2)	222942	3	3	2	9	2	0	0	0	1	0	1.000	0.858	1.000
11	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(1), PAPSS1(5), PAPSS2(1), SULT1A2(3), SUOX(1)	613543	11	7	9	2	4	2	0	4	1	0	0.359	0.872	1.000
12	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	SPCS1(1)	225000	1	1	1	3	0	0	0	0	1	0	1.000	0.885	1.000
13	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), ITPKA(1), ITPKB(10)	444148	15	10	10	9	3	7	0	3	2	0	0.854	0.890	1.000
14	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), GLS(1), PRODH(4)	430702	7	5	6	3	3	1	1	2	0	0	0.649	0.947	1.000
15	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(3)	278637	3	3	3	5	0	0	0	2	1	0	0.999	0.960	1.000
16	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3D(1), CD3G(2)	235227	3	3	3	7	0	1	0	1	1	0	0.998	0.961	1.000
17	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), SQLE(1)	243414	3	3	3	9	0	0	2	0	1	0	1.000	0.968	1.000
18	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(8), AASDHPPT(2), AASS(2)	502133	12	8	9	7	2	4	0	4	2	0	0.904	0.969	1.000
19	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT1(1), FUT2(1), FUT3(6), FUT5(6)	318938	14	7	9	9	5	2	0	6	1	0	0.924	0.975	1.000
20	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1), SNAP25(1)	230341	2	2	2	7	0	0	0	1	1	0	0.999	0.975	1.000
21	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(4), CHKA(1), PDHA2(2), PEMT(4)	503543	12	10	10	5	5	5	1	1	0	0	0.476	0.976	1.000
22	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PNPO(1)	351159	5	5	5	9	1	3	0	0	1	0	0.999	0.981	1.000
23	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), EIF2S2(1), NFKB1(3), NFKBIA(3)	688437	8	8	7	6	2	2	0	1	3	0	0.963	0.986	1.000
24	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GGT1(6), SHMT1(3), SHMT2(1)	423071	12	12	8	5	3	3	1	4	1	0	0.676	0.987	1.000
25	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(1), SP1(1), SP3(2)	488712	7	6	7	5	1	4	0	0	2	0	0.873	0.987	1.000
26	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(1), CCND1(1), CDKN1B(1), CDKN2A(1), E2F1(2), E2F2(3)	612430	9	7	8	9	2	1	1	3	2	0	0.986	0.987	1.000
27	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(2), E2F1(2), RB1(1)	618831	5	5	5	6	2	1	0	0	2	0	0.987	0.988	1.000
28	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDKN1B(1), CUL1(2), E2F1(2), NEDD8(1), RB1(1), SKP2(1)	626122	8	7	8	6	3	1	0	1	3	0	0.934	0.989	1.000
29	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	8	EIF2AK4(1), EIF2B5(4), EIF2S2(1), EIF2S3(2), PPP1CA(1)	687368	9	9	8	4	2	3	0	4	0	0	0.790	0.989	1.000
30	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CUL1(2), E2F1(2), RB1(1), SKP2(1)	635036	7	6	7	7	3	1	0	0	3	0	0.972	0.990	1.000
31	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	7	ACLY(2), PC(1)	603220	3	3	2	1	0	0	0	3	0	0	0.794	0.991	1.000
32	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(2), MST1R(6), TNF(3)	468866	12	8	10	7	1	5	3	2	1	0	0.838	0.994	1.000
33	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	8	ECHS1(1), HADHB(1), HSD17B4(4), PPT1(1)	524179	7	5	6	6	0	5	1	0	1	0	0.941	0.996	1.000
34	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(3), MTMR2(4), PHPT1(1), THTPA(2)	464267	10	8	9	8	2	2	0	5	1	0	0.975	0.996	1.000
35	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), ACADM(1), ACADS(1), ACAT1(2), ECHS1(1)	400262	8	8	6	5	0	3	0	4	1	0	0.927	0.997	1.000
36	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(5), GLS(1)	565382	6	5	3	6	0	0	0	5	1	0	0.994	0.998	1.000
37	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	10	CDK5R1(1), CSNK1A1(2), PPP2CA(1)	608846	4	4	4	6	0	1	0	1	2	0	0.994	0.999	1.000
38	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(2), CSNK1E(1), PER1(4)	633431	7	5	6	9	1	2	0	3	1	0	0.999	1.000	1.000
39	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(1), BDH1(1), BDH2(2), HMGCS2(1), OXCT1(2), OXCT2(2)	555702	11	8	9	9	3	3	1	3	1	0	0.970	1.000	1.000
40	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(1), NFKB1(3), TNFRSF13B(4), TNFSF13(3), TNFSF13B(1), TRAF3(4), TRAF6(1)	1058732	18	9	14	9	3	11	1	1	2	0	0.815	1.000	1.000
41	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(5), ACTN1(3), ACTN2(1), ACTN4(1), AKT2(1), ARHGAP5(2), BCAR1(2), BCL2(1), BIRC2(1), BRAF(3), CAPN2(4), CAV1(1), CAV2(2), CCND1(1), CCND2(2), CCND3(3), CHAD(1), COL11A1(7), COL11A2(5), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A6(4), COMP(2), DOCK1(7), EGF(4), EGFR(4), ELK1(1), ERBB2(3), FARP2(10), FLNA(4), FLNC(7), FLT1(2), FN1(2), GRB2(1), IBSP(5), ILK(1), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGB3(3), ITGB4(2), KDR(8), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), MAP2K1(2), MAPK8(1), MET(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PARVA(1), PARVG(1), PDGFC(1), PDGFRB(2), PDPK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PRKCG(2), PTEN(2), PTK2(2), RAC1(1), RAC3(1), RAF1(4), RAPGEF1(1), RELN(9), RHOA(2), ROCK2(2), SHC2(1), SHC3(1), SOS1(1), SOS2(1), SPP1(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TLN1(6), TLN2(6), TNC(10), TNN(10), TNR(4), TNXB(14), VAV1(3), VAV2(3), VAV3(4), VEGFB(1), VEGFC(2), VTN(2), VWF(11)	26316426	459	41	369	655	124	145	26	124	37	3	1.000	1.000	1.000
42	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	228	ADCYAP1R1(4), ADORA1(1), ADORA3(4), ADRA1A(3), ADRA2B(2), ADRA2C(1), ADRB1(1), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1B(3), CALCR(5), CALCRL(2), CCKBR(1), CHRM3(5), CNR2(4), CRHR1(1), CTSG(1), CYSLTR1(1), CYSLTR2(2), DRD2(1), DRD3(1), DRD5(5), EDNRA(1), F2(1), F2R(1), F2RL2(1), F2RL3(1), FPR1(8), FSHR(5), GABBR1(1), GABBR2(3), GABRA1(2), GABRA2(2), GABRA3(1), GABRA5(1), GABRA6(3), GABRB1(1), GABRD(2), GABRE(1), GABRG3(6), GABRP(2), GABRQ(4), GABRR2(2), GALR1(3), GALR2(1), GALR3(1), GH1(2), GH2(1), GHR(2), GHRHR(2), GHSR(1), GIPR(1), GLP1R(3), GLP2R(3), GLRB(1), GPR156(1), GPR35(1), GPR50(7), GPR63(1), GRIA2(3), GRID1(7), GRID2(5), GRIK1(3), GRIK2(1), GRIK3(1), GRIK4(3), GRIK5(1), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), GRIN3A(13), GRIN3B(10), GRM1(2), GRM2(1), GRM4(1), GRM5(1), GRM6(5), GRM7(1), HCRTR1(2), HCRTR2(2), HRH1(1), HRH2(1), HRH4(3), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), LEPR(10), LHB(3), MAS1(1), MC1R(4), MC3R(2), MC5R(1), MCHR1(2), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(2), NPBWR2(2), NPFFR2(2), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OXTR(1), P2RX3(5), P2RX4(2), P2RX7(15), P2RY1(1), P2RY10(1), P2RY11(3), P2RY13(1), P2RY4(1), P2RY6(1), PARD3(2), PRLHR(1), PRLR(2), PRSS1(4), PTAFR(2), PTGFR(1), PTGIR(2), PTH2R(2), RXFP2(4), SCTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6), SSTR5(3), TAAR2(1), TAAR6(2), TAAR8(1), TACR2(4), TACR3(1), THRA(1), THRB(2), TRPV1(5), TSHR(3), VIPR2(1)	15716193	347	40	283	448	80	121	26	102	18	0	1.000	1.000	1.000
43	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(4), AXIN2(4), BTRC(1), CAMK2G(1), CCND1(1), CCND2(2), CCND3(3), CER1(4), CHD8(4), CREBBP(7), CSNK1A1(2), CSNK1A1L(5), CSNK1E(1), CSNK2A1(4), CSNK2B(1), CUL1(2), DAAM2(4), DKK2(2), DVL1(1), EP300(5), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), LRP5(2), LRP6(1), MAPK8(1), MMP7(2), MYC(7), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NKD2(2), PLCB1(8), PLCB3(2), PLCB4(2), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE2(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PSEN1(1), RAC1(1), RAC3(1), RHOA(2), ROCK2(2), SENP2(1), SFRP4(2), SKP1(1), SMAD3(1), SOX17(1), TBL1XR1(2), TCF7(2), TCF7L1(2), VANGL1(4), VANGL2(1), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2)	11891521	158	40	141	197	42	43	5	44	24	0	1.000	1.000	1.000
44	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1C(2), AKT2(1), ATF4(4), BDNF(3), BRAF(3), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1F(6), CACNA1G(2), CACNA1H(15), CACNA1I(1), CACNA1S(8), CACNA2D1(3), CACNA2D2(2), CACNA2D3(1), CACNA2D4(3), CACNB2(2), CACNB4(1), CACNG1(1), CACNG3(1), CACNG6(2), CACNG7(1), CHUK(1), DUSP16(2), DUSP4(2), DUSP8(1), ECSIT(3), EGF(4), EGFR(4), ELK1(1), FGF12(1), FGF14(1), FGF16(1), FGF21(2), FGF5(1), FGF6(3), FGFR2(2), FGFR4(6), FLNA(4), FLNC(7), GRB2(1), IKBKB(2), IL1A(2), IL1R1(1), IL1R2(1), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP4K1(1), MAP4K3(2), MAP4K4(1), MAPK11(1), MAPK7(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MAPKAPK2(1), MAPKAPK5(2), MEF2C(1), MKNK1(1), MKNK2(3), MOS(2), MYC(7), NF1(2), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(3), NTRK1(3), PAK2(11), PDGFRB(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PPM1A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PTPN5(3), PTPN7(1), PTPRR(3), RAC1(1), RAC3(1), RAF1(4), RAPGEF2(1), RASA1(2), RASA2(2), RASGRF1(2), RASGRF2(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(1), RPS6KA5(1), RPS6KA6(1), RRAS2(1), SOS1(1), SOS2(1), STK3(2), STK4(1), TAOK1(1), TAOK2(2), TGFB2(1), TNF(3), TRAF6(1), ZAK(3)	21423931	276	39	236	402	85	86	13	65	27	0	1.000	1.000	1.000
45	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	148	AKT2(1), CBL(1), CBLB(1), CBLC(5), CCND1(1), CCND2(2), CCND3(3), CISH(1), CLCF1(1), CREBBP(7), CRLF2(1), CSF2(1), CSF2RA(2), CSF2RB(3), CSF3R(2), EP300(5), EPOR(1), GH1(2), GH2(1), GHR(2), GRB2(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), IL10RA(4), IL10RB(2), IL11(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL13RA1(1), IL15RA(1), IL19(1), IL21R(1), IL22RA1(2), IL22RA2(2), IL23R(2), IL24(3), IL2RA(1), IL2RB(2), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL6ST(4), IL7R(7), IL9(1), IL9R(2), JAK1(2), JAK2(2), JAK3(2), LEPR(10), LIFR(3), MYC(7), OSMR(2), PIAS1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIM1(38), PRLR(2), PTPN6(4), SOCS1(9), SOCS3(1), SOCS7(2), SOS1(1), SOS2(1), SPRED1(1), SPRED2(1), SPRY3(1), STAT1(1), STAT2(3), STAT6(4), TPO(10), TYK2(3)	10466120	264	39	217	216	32	97	22	89	21	3	1.000	1.000	1.000
46	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	125	ACTB(5), CHAD(1), COL11A1(7), COL11A2(5), COL17A1(3), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A6(4), COMP(2), DES(2), DSC1(3), DSC2(1), DSC3(8), DSG2(2), DSG3(6), DSG4(2), FN1(2), GJA1(1), GJA4(5), GJA9(5), GJB3(1), GJB4(3), GJB7(3), GJD2(1), GJD4(1), IBSP(5), ITGA6(4), ITGB4(2), KRT1(4), KRT10(2), KRT12(2), KRT14(4), KRT15(3), KRT16(2), KRT17(1), KRT19(2), KRT20(2), KRT23(4), KRT24(2), KRT25(3), KRT27(6), KRT31(3), KRT32(16), KRT33A(5), KRT33B(5), KRT34(2), KRT35(4), KRT36(3), KRT37(16), KRT38(2), KRT39(4), KRT40(23), KRT5(7), KRT6A(4), KRT6B(5), KRT6C(7), KRT7(3), KRT72(10), KRT73(4), KRT75(5), KRT76(6), KRT77(7), KRT78(4), KRT79(3), KRT81(3), KRT83(4), KRT85(1), KRT86(3), KRT9(1), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), LMNA(3), NES(7), PRPH(2), RELN(9), SPP1(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNC(10), TNN(10), TNR(4), TNXB(14), VTN(2), VWF(11)	16806935	502	38	376	533	163	154	28	117	38	2	1.000	1.000	1.000
47	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	124	ABL1(3), ABLIM1(2), ABLIM2(1), ABLIM3(4), ARHGEF12(2), DCC(4), EFNA1(1), EFNB1(1), EPHA1(3), EPHA2(2), EPHA3(7), EPHA5(3), EPHA6(3), EPHA7(2), EPHA8(1), EPHB1(3), EPHB2(1), EPHB4(2), EPHB6(2), GNAI2(2), L1CAM(1), LIMK1(1), LIMK2(1), LRRC4C(1), MET(2), NCK1(2), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NGEF(1), NRP1(5), NTN4(4), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PLXNA1(1), PLXNA2(10), PLXNA3(4), PLXNB1(1), PLXNB2(5), PLXNB3(10), PLXNC1(1), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC3(1), RASA1(2), RGS3(4), RHOA(2), ROBO1(2), ROBO2(3), ROBO3(2), ROCK2(2), SEMA3A(1), SEMA3C(3), SEMA3D(4), SEMA3E(4), SEMA3F(1), SEMA3G(1), SEMA4B(2), SEMA4D(5), SEMA4F(1), SEMA4G(1), SEMA5A(2), SEMA5B(6), SEMA6A(2), SEMA6B(2), SEMA6C(2), SEMA6D(7), SEMA7A(1), SLIT1(2), SLIT2(3), SLIT3(4), SRGAP1(2), SRGAP2(2), SRGAP3(1), UNC5B(7), UNC5C(6), UNC5D(1)	14650195	229	38	190	367	73	70	11	65	10	0	1.000	1.000	1.000
48	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(1), ACVRL1(1), AURKB(3), BMPR1A(3), BUB1(1), CDKL1(2), CDKL2(1), CDS1(1), CDS2(1), CLK2(2), CSNK2A1(4), CSNK2B(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), INPP4A(3), INPP4B(5), INPP5A(2), INPPL1(1), ITPKA(1), ITPKB(10), MAP3K10(1), MOS(2), NEK1(8), NEK3(3), OCRL(1), PAK4(2), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3CA(2), PIK3CG(3), PIM2(1), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCG1(3), PLCG2(5), PRKACA(1), PRKACG(2), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), PRKG1(3), RAF1(4), RPS6KA1(2), RPS6KA2(1), STK11(1)	8511200	138	37	120	214	34	38	7	42	17	0	1.000	1.000	1.000
49	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY2(7), ADCY3(2), ADCY4(2), ADCY8(1), ADCY9(4), ADRA1A(3), ADRA1D(2), ADRB1(1), ADRB2(3), AGTR1(2), ATP2A3(2), ATP2B4(1), AVPR1B(3), BST1(4), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1F(6), CACNA1G(2), CACNA1H(15), CACNA1I(1), CACNA1S(8), CAMK2G(1), CAMK4(1), CCKBR(1), CHRM3(5), CHRNA7(1), CYSLTR1(1), CYSLTR2(2), EDNRA(1), EGFR(4), ERBB2(3), ERBB3(1), ERBB4(4), F2R(1), GNA14(1), GNAS(1), GRIN2A(2), GRIN2C(3), GRIN2D(1), GRM1(2), GRM5(1), HRH1(1), HRH2(1), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), MYLK(8), NOS1(3), OXTR(1), P2RX3(5), P2RX4(2), P2RX7(15), PDE1B(1), PDE1C(5), PDGFRB(2), PHKA1(1), PHKB(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PPID(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PTAFR(2), PTGFR(1), PTK2B(4), RYR1(4), RYR2(9), RYR3(6), SLC25A5(2), SLC25A6(2), SLC8A1(1), SLC8A3(1), SPHK1(1), SPHK2(1), TACR2(4), TACR3(1), TRPC1(1), VDAC3(2)	20484450	286	36	234	521	86	79	17	71	32	1	1.000	1.000	1.000
50	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	241	ACVR1(1), BMP2(2), BMP7(1), BMPR1A(3), CCL11(1), CCL14(5), CCL15(1), CCL18(1), CCL2(1), CCL23(2), CCL25(2), CCL8(3), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CD27(3), CLCF1(1), CRLF2(1), CSF1(2), CSF2(1), CSF2RA(2), CSF2RB(3), CSF3R(2), CX3CL1(2), CXCL14(1), CXCL2(1), CXCL3(1), CXCR6(1), EDA(1), EDA2R(4), EGF(4), EGFR(4), EPOR(1), FLT1(2), FLT3(1), FLT3LG(1), FLT4(5), GDF5(3), GH1(2), GH2(1), GHR(2), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), IL10RA(4), IL10RB(2), IL11(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL13RA1(1), IL15RA(1), IL17B(1), IL17RA(2), IL17RB(1), IL18R1(1), IL19(1), IL1A(2), IL1R1(1), IL1R2(1), IL21R(1), IL22RA1(2), IL22RA2(2), IL23R(2), IL24(3), IL25(1), IL2RA(1), IL2RB(2), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL6ST(4), IL7R(7), IL9(1), IL9R(2), INHBB(1), INHBC(1), INHBE(1), KDR(8), KITLG(1), LEPR(10), LIFR(3), LTB(5), MET(2), NGFR(2), OSMR(2), PDGFC(1), PDGFRB(2), PLEKHO2(5), PRLR(2), TGFB2(1), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(4), TNFRSF18(3), TNFRSF19(4), TNFRSF1B(3), TNFRSF21(1), TNFRSF6B(1), TNFSF13(3), TNFSF13B(1), TNFSF15(1), TNFSF4(1), TNFSF9(1), TPO(10), VEGFB(1), VEGFC(2), XCL1(2)	12657210	309	36	239	281	48	119	26	99	17	0	1.000	1.000	1.000
51	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	120	ALCAM(3), CADM1(1), CADM3(1), CD2(1), CD22(2), CD274(1), CD276(7), CD58(1), CD6(8), CD80(2), CD86(1), CD8B(5), CD99(3), CDH1(1), CDH15(2), CDH2(4), CDH3(6), CDH4(2), CLDN18(1), CLDN22(2), CLDN5(2), CNTN1(2), CNTN2(5), CNTNAP1(2), CTLA4(1), HLA-A(93), HLA-B(42), HLA-C(60), HLA-DMA(4), HLA-DMB(1), HLA-DOB(1), HLA-DPA1(29), HLA-DQA1(19), HLA-DQA2(8), HLA-DQB1(30), HLA-DRA(2), HLA-DRB1(46), HLA-E(1), HLA-G(5), ICAM1(6), ICOSLG(4), ITGA4(5), ITGA6(4), ITGA8(1), ITGA9(2), ITGAL(1), ITGAM(6), L1CAM(1), MPZL1(1), NCAM1(1), NCAM2(5), NEGR1(3), NFASC(5), NLGN1(1), NRCAM(2), NRXN1(2), NRXN2(2), NRXN3(3), PDCD1LG2(2), PTPRC(1), PTPRF(1), PTPRM(1), PVR(3), PVRL1(3), PVRL2(1), SDC3(5), SDC4(5), SELE(3), SELL(3), SELP(6), SIGLEC1(4), VCAM1(1), VCAN(21)	10413394	522	36	369	436	90	191	23	181	32	5	1.000	1.000	1.000
52	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	125	ACTB(5), ACTN1(3), ACTN2(1), ACTN4(1), AKT2(1), AMOTL1(5), ASH1L(2), CGN(5), CLDN18(1), CLDN22(2), CLDN5(2), CSNK2A1(4), CSNK2B(1), CTNNA2(3), CTNNA3(6), CTTN(1), EPB41(2), EPB41L1(1), EPB41L2(1), EPB41L3(6), EXOC4(3), GNAI2(2), HCLS1(7), IGSF5(4), INADL(11), LLGL1(2), LLGL2(9), MAGI1(3), MAGI2(4), MLLT4(1), MPDZ(6), MYH1(4), MYH10(3), MYH11(5), MYH13(5), MYH14(4), MYH15(6), MYH2(2), MYH3(1), MYH4(14), MYH6(6), MYH7(1), MYH7B(4), MYH8(5), MYH9(6), PARD3(2), PARD6G(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(13), PPP2R3B(3), PPP2R4(1), PRKCD(1), PRKCG(2), PRKCQ(2), PTEN(2), RHOA(2), RRAS2(1), SPTAN1(1), SYMPK(2), TJP1(3), TJP2(5), TJP3(5), YES1(1), ZAK(3)	14066887	227	36	182	325	69	72	19	47	20	0	1.000	1.000	1.000
53	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CDS1(1), CDS2(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(2), INPP5B(4), INPPL1(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), OCRL(1), PI4KA(4), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3C3(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PRKCG(2), PTEN(2), SYNJ1(2), SYNJ2(3)	9334304	130	35	115	251	29	35	8	37	21	0	1.000	1.000	1.000
54	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ACTN1(3), ACTN2(1), ACTN4(1), APC(4), ARHGEF1(1), ARHGEF12(2), ARHGEF4(2), ARPC1B(3), BCAR1(2), BRAF(3), CHRM3(5), CSK(3), DIAPH3(2), DOCK1(7), EGF(4), EGFR(4), EZR(1), F2(1), F2R(1), FGF12(1), FGF14(1), FGF16(1), FGF21(2), FGF5(1), FGF6(3), FGFR2(2), FGFR4(6), FN1(2), GNA13(2), GSN(4), IQGAP2(4), IQGAP3(8), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGAD(2), ITGAE(8), ITGAL(1), ITGAM(6), ITGAX(6), ITGB3(3), ITGB4(2), LIMK1(1), LIMK2(1), MAP2K1(2), MOS(2), MSN(2), MYH10(3), MYH14(4), MYH9(6), MYLK(8), NCKAP1(2), NCKAP1L(1), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PDGFRB(2), PFN1(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PPP1R12B(1), PTK2(2), RAC1(1), RAC3(1), RAF1(4), RHOA(2), ROCK2(2), RRAS2(1), SCIN(5), SOS1(1), SOS2(1), SSH1(2), SSH2(3), SSH3(1), TIAM1(8), TIAM2(9), VAV1(3), VAV2(3), VAV3(4), WAS(1), WASF1(1), WASL(1)	20650689	280	34	225	414	86	87	13	76	17	1	1.000	1.000	1.000
55	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(5), BCL2(1), CABIN1(4), CAMK4(1), CD3G(2), CDKN1A(4), CREBBP(7), CSF2(1), CSNK2A1(4), CSNK2B(1), CTLA4(1), EGR2(1), EP300(5), GATA3(2), GATA4(2), IFNA1(2), IL2RA(1), IL3(3), IL6(2), JUNB(1), MAPK8(1), MEF2B(3), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB2(3), NFKBIB(1), NUP214(3), P2RX7(15), PPP3CC(1), PTPRC(1), SFN(2), SLA(1), SP1(1), SP3(2), TNF(3), VAV1(3), VAV2(3), VAV3(4), XPO5(2)	6659209	110	33	93	132	25	36	4	31	14	0	1.000	1.000	1.000
56	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	83	ABL1(3), AKT2(1), BRAF(3), CAMK2G(1), CBL(1), CBLB(1), CBLC(5), CDKN1A(4), CDKN1B(1), EGF(4), EGFR(4), ELK1(1), ERBB2(3), ERBB3(1), ERBB4(4), GAB1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAPK8(1), MYC(7), NCK1(2), NRG1(4), NRG2(1), NRG3(2), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PRKCG(2), PTK2(2), RAF1(4), RPS6KB2(5), SHC2(1), SHC3(1), SOS1(1), SOS2(1)	7626194	115	33	94	169	21	43	10	33	8	0	1.000	1.000	1.000
57	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	120	BRAF(3), CD247(1), CD48(2), CSF2(1), GRB2(1), GZMB(5), HLA-A(93), HLA-B(42), HLA-C(60), HLA-E(1), HLA-G(5), ICAM1(6), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), ITGAL(1), KIR2DL3(2), KIR3DL1(16), KIR3DL2(3), KLRK1(1), LCP2(1), MAP2K1(2), MICA(31), NCR1(1), NCR2(3), NCR3(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PPP3CA(1), PPP3CC(1), PRF1(2), PRKCG(2), PTK2B(4), PTPN6(4), RAC1(1), RAC3(1), RAF1(4), SHC2(1), SHC3(1), SOS1(1), SOS2(1), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1), ULBP3(2), VAV1(3), VAV2(3), VAV3(4), ZAP70(1)	8138926	392	33	284	330	56	138	18	147	29	4	1.000	1.000	1.000
58	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), CAMK2G(1), CREB3L1(2), CREB3L2(1), CREB3L4(2), CREBBP(7), DCT(1), DVL1(1), EP300(5), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), GNAI2(2), GNAS(1), KITLG(1), MAP2K1(2), MC1R(4), MITF(1), PLCB1(8), PLCB3(2), PLCB4(2), POMC(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), RAF1(4), TCF7(2), TCF7L1(2), TYRP1(1), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2)	7989402	99	33	86	167	21	33	6	25	14	0	1.000	1.000	1.000
59	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADORA1(1), ADORA3(4), ADRA1A(3), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1B(3), CCKBR(1), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CCRL2(4), CHML(2), CHRM3(5), CMKLR1(1), CNR2(4), DRD2(1), DRD3(1), DRD5(5), EDNRA(1), F2R(1), F2RL2(1), F2RL3(1), FPR1(8), FSHR(5), GALR1(3), GALR2(1), GALR3(1), GALT(2), GHSR(1), GPR35(1), GPR37L1(1), GPR50(7), GPR63(1), GPR87(2), HCRTR1(2), HCRTR2(2), HRH1(1), HRH2(1), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), MAS1(1), MC1R(4), MC3R(2), MC5R(1), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(2), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OR10A5(1), OR11A1(3), OR12D3(5), OR1F1(4), OR1Q1(3), OR2H1(4), OR5V1(4), OR7A5(1), OR7C1(7), OXTR(1), P2RY1(1), P2RY10(1), P2RY11(3), P2RY13(1), P2RY6(1), PTAFR(2), PTGFR(1), PTGIR(2), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6)	8605749	187	32	153	247	28	72	12	68	7	0	1.000	1.000	1.000
60	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(1), ACVR1C(2), ACVRL1(1), BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP7(1), BMP8A(1), BMPR1A(3), CDKN2B(1), CHRD(4), COMP(2), CREBBP(7), CUL1(2), EP300(5), GDF5(3), ID3(2), INHBB(1), INHBC(1), INHBE(1), LEFTY1(6), LTBP1(4), MYC(7), NODAL(1), PITX2(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL2(3), RHOA(2), ROCK2(2), RPS6KB2(5), SKP1(1), SMAD3(1), SMAD7(1), SMAD9(3), SMURF1(1), SMURF2(1), SP1(1), TGFB2(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNF(3), ZFYVE9(2)	7290751	107	32	91	118	23	40	3	29	12	0	1.000	1.000	1.000
61	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	72	ACTB(5), ACTN1(3), ACTN2(1), ACTN4(1), ACVR1C(2), CDH1(1), CREBBP(7), CSNK2A1(4), CSNK2B(1), CTNNA2(3), CTNNA3(6), CTNND1(1), EGFR(4), EP300(5), ERBB2(3), FARP2(10), FER(3), INSR(2), LMO7(10), MET(2), MLLT4(1), PARD3(2), PTPN1(1), PTPN6(4), PTPRB(8), PTPRF(1), PTPRJ(6), PTPRM(1), PVRL1(3), PVRL2(1), PVRL4(1), RAC1(1), RAC3(1), RHOA(2), SMAD3(1), SNAI1(2), SORBS1(4), SSX2IP(3), TCF7(2), TCF7L1(2), TJP1(3), WAS(1), WASF1(1), WASF3(3), WASL(1), YES1(1)	8670606	131	32	116	167	28	50	4	36	13	0	1.000	1.000	1.000
62	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY8(1), ATF4(4), BRAF(3), CACNA1C(8), CAMK2G(1), CAMK4(1), CREBBP(7), EP300(5), GRIA2(3), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), GRM1(2), GRM5(1), ITPR1(4), ITPR2(3), ITPR3(2), MAP2K1(2), PLCB1(8), PLCB3(2), PLCB4(2), PPP1CA(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), RAF1(4), RAPGEF3(8), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1)	7533361	93	32	82	187	23	22	4	29	15	0	1.000	1.000	1.000
63	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	82	AGRN(4), CD36(1), CD44(3), CHAD(1), COL11A1(7), COL11A2(5), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A6(4), FN1(2), FNDC1(8), FNDC3A(2), FNDC4(1), GP6(2), GP9(1), HSPG2(15), IBSP(5), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGB3(3), ITGB4(2), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), RELN(9), SDC3(5), SDC4(5), SPP1(1), SV2B(2), SV2C(3), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNC(10), TNN(10), TNR(4), TNXB(14), VTN(2), VWF(11)	15848647	324	31	255	467	105	100	20	73	23	3	1.000	1.000	1.000
64	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADRA1A(3), ADRA1D(2), ADRB1(1), ADRB2(3), ATP1A4(1), ATP2A3(2), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1S(8), CALR(1), CAMK2G(1), CAMK4(1), CASQ1(1), CHRM3(5), GJA1(1), GJA4(5), GJB3(1), GJB4(3), GNAI2(2), GNB3(1), GNGT1(1), GRK4(6), GRK5(2), GRK6(1), ITPR1(4), ITPR2(3), ITPR3(2), KCNB1(1), KCNJ3(1), KCNJ5(1), PLCB3(2), PRKACA(1), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), RGS1(1), RGS11(3), RGS14(2), RGS18(2), RGS3(4), RGS6(1), RGS7(1), RGS9(1), RYR1(4), RYR2(9), RYR3(6), SFN(2), SLC8A1(1), SLC8A3(1)	14128741	153	30	127	357	42	51	7	34	18	1	1.000	1.000	1.000
65	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	81	AGL(6), AMY2A(1), AMY2B(2), ASCC3(5), ATP13A2(1), DDX18(2), DDX23(1), DDX41(2), DDX47(2), DDX51(6), DDX52(4), DDX54(2), DDX55(3), DHX58(5), ENPP1(3), ENPP3(3), ENTPD7(3), EP400(7), ERCC2(4), G6PC2(6), GAA(1), GANC(5), GBA(2), GBE1(3), GUSB(1), GYS2(2), HK1(1), HK2(4), HK3(1), IFIH1(7), LYZL1(1), MGAM(12), MOV10L1(17), NUDT5(1), PGM1(4), PGM3(1), PYGB(6), PYGL(4), RAD54B(2), SETX(8), SI(5), SKIV2L2(2), SMARCA2(8), SMARCA5(1), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), UXS1(1)	9565232	211	30	153	226	36	69	12	74	20	0	1.000	1.000	1.000
66	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	64	CALR(1), CANX(1), CD8B(5), CIITA(10), CTSS(2), HLA-A(93), HLA-B(42), HLA-C(60), HLA-DMA(4), HLA-DMB(1), HLA-DOB(1), HLA-DPA1(29), HLA-DQA1(19), HLA-DQA2(8), HLA-DQB1(30), HLA-DRA(2), HLA-DRB1(46), HLA-E(1), HLA-G(5), HSP90AA1(2), IFI30(2), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), KIR2DL3(2), KIR3DL1(16), KIR3DL2(3), KIR3DL3(3), LGMN(1), NFYA(1), NFYC(2), PDIA3(1), RFX5(4), RFXANK(2), RFXAP(1), TAP1(5), TAP2(5)	3096880	425	30	294	270	57	152	19	166	28	3	1.000	1.000	1.000
67	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT2(1), BCL10(2), CBL(1), CBLB(1), CBLC(5), CD247(1), CD3D(1), CD3G(2), CD8B(5), CHUK(1), CSF2(1), CTLA4(1), GRAP2(1), GRB2(1), IKBKB(2), LCP2(1), MALT1(1), NCK1(2), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCQ(2), PTPN6(4), PTPRC(1), RHOA(2), SOS1(1), SOS2(1), TEC(2), TNF(3), VAV1(3), VAV2(3), VAV3(4), ZAP70(1)	7285366	114	30	94	148	28	35	5	30	16	0	1.000	1.000	1.000
68	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(3), CHUK(1), ELK1(1), GRB2(1), IKBKB(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP4K1(1), MAP4K3(2), MAP4K4(1), MAP4K5(3), MAPK11(1), MAPK4(1), MAPK7(1), MAPK8(1), MAPKAPK2(1), MAPKAPK5(2), MEF2B(3), MEF2C(1), MKNK1(1), MKNK2(3), MYC(7), NFKB1(3), NFKBIA(3), PAK2(11), RAC1(1), RAF1(4), RPS6KA1(2), RPS6KA2(1), RPS6KA5(1), RPS6KB2(5), SP1(1), STAT1(1), TGFB2(1)	7240715	95	30	80	132	16	29	9	29	12	0	1.000	1.000	1.000
69	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ATF1(1), ATF4(4), ATF5(2), ATP2A3(2), CALCA(1), CAMK2G(1), CNN1(1), CRHR1(1), DGKZ(4), ETS2(2), GABPB2(1), GBA2(1), GJA1(1), GNB3(1), GNGT1(1), GRK4(6), GRK5(2), GRK6(1), GUCA2A(2), GUCA2B(1), GUCY1A3(1), IGFBP1(2), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(4), ITPR2(3), ITPR3(2), NFKB1(3), NOS1(3), OXTR(1), PLCB3(2), PLCD1(2), PLCG1(3), PLCG2(5), PRKACA(1), PRKCD(1), PRKCQ(2), PRKD1(3), RAMP3(1), RGS1(1), RGS11(3), RGS14(2), RGS18(2), RGS3(4), RGS6(1), RGS7(1), RGS9(1), RYR1(4), RYR2(9), RYR3(6), SFN(2), SLC8A1(1), SP1(1), TNXB(14)	13015171	148	30	125	337	38	60	7	30	12	1	1.000	1.000	1.000
70	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(3), ACTN1(3), AKT2(1), ANGPTL2(1), BCAR1(2), BRAF(3), CAV1(1), CDKN2A(1), DOCK1(7), EPHB2(1), GRB2(1), ILK(1), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), MAP2K4(1), MAP3K11(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PLCG1(3), PLCG2(5), PTEN(2), PTK2(2), RAF1(4), ROCK2(2), SOS1(1), SOS2(1), TERF2IP(1), TLN1(6), TLN2(6), WAS(1)	9117849	131	30	104	182	34	43	12	32	9	1	1.000	1.000	1.000
71	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(8), ABCA10(3), ABCA12(3), ABCA13(31), ABCA2(3), ABCA3(4), ABCA4(8), ABCA5(3), ABCA7(14), ABCA8(9), ABCA9(1), ABCB1(6), ABCB10(1), ABCB11(2), ABCB5(15), ABCB6(1), ABCB8(6), ABCB9(1), ABCC1(3), ABCC10(2), ABCC11(4), ABCC12(7), ABCC2(4), ABCC3(5), ABCC4(2), ABCC6(12), ABCC8(1), ABCD2(1), ABCD4(6), ABCG2(3), ABCG4(3), ABCG8(5), CFTR(5), TAP1(5), TAP2(5)	8547992	192	29	148	178	51	63	7	50	21	0	1.000	1.000	1.000
72	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT2(1), BCL10(2), BTK(2), CD19(2), CD22(2), CD72(2), CD79A(2), CHUK(1), CR2(7), FCGR2B(1), IKBKB(2), LILRB3(34), LYN(2), MALT1(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG2(5), PPP3CA(1), PPP3CC(1), PTPN6(4), RAC1(1), RAC3(1), VAV1(3), VAV2(3), VAV3(4)	5268389	113	29	89	124	21	41	3	33	15	0	1.000	1.000	1.000
73	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	BCAR1(2), CAPN10(1), CAPN11(5), CAPN2(4), CAPN3(1), CAPN6(1), CAPN7(1), CAPN9(7), CAV1(1), CAV2(2), CSK(3), DOCK1(7), GIT2(2), GRB2(1), ILK(1), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGAD(2), ITGAE(8), ITGAL(1), ITGAM(6), ITGAX(6), ITGB3(3), ITGB4(2), MAP2K1(2), MAP2K3(4), MAPK4(1), MAPK7(1), PAK2(11), PAK4(2), PAK6(3), PDPK1(1), PIK3R2(1), PTK2(2), RAC1(1), RAC3(1), RAPGEF1(1), ROCK2(2), SDCCAG8(2), SHC3(1), SORBS1(4), SOS1(1), TLN1(6), TNS1(15), VAV2(3), VAV3(4)	10052147	167	29	125	248	50	49	11	44	12	1	1.000	1.000	1.000
74	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(1), CD3D(1), CSK(3), CTLA4(1), EPHB2(1), GRAP2(1), GRB2(1), ITPKA(1), ITPKB(10), LCP2(1), NCK1(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PLCG1(3), PTPRC(1), RAF1(4), RASGRP4(1), SOS1(1), SOS2(1), VAV1(3), ZAP70(1)	4182020	72	29	55	66	16	26	6	16	8	0	1.000	1.000	1.000
75	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	ADAM17(1), CREBBP(7), DLL3(1), DTX1(4), DTX2(2), DTX3L(3), DTX4(2), DVL1(1), EP300(5), HDAC2(2), JAG1(3), JAG2(4), LFNG(1), MAML1(4), MAML2(3), NCOR2(9), NOTCH1(2), NOTCH2(10), NOTCH3(5), NOTCH4(10), NUMB(2), NUMBL(1), PSEN1(1), PTCRA(6), RBPJL(6)	5249524	95	28	76	109	22	29	1	29	14	0	1.000	1.000	1.000
76	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(4), CD19(2), CD1A(2), CD1B(1), CD1C(2), CD1D(1), CD1E(3), CD2(1), CD22(2), CD36(1), CD3D(1), CD3G(2), CD44(3), CD5(3), CD8B(5), CR2(7), CSF1(2), CSF2(1), CSF2RA(2), CSF3R(2), EPOR(1), FCER2(3), FLT3(1), FLT3LG(1), GP9(1), HLA-DRA(2), HLA-DRB1(46), IL11(1), IL1A(2), IL1R1(1), IL1R2(1), IL2RA(1), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL7R(7), IL9R(2), ITGA1(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGAM(6), ITGB3(3), KITLG(1), MME(4), TFRC(2), TNF(3), TPO(10)	5718041	192	28	145	168	33	79	14	54	11	1	1.000	1.000	1.000
77	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(2), ACACB(12), AKT2(1), BRAF(3), CBL(1), CBLB(1), CBLC(5), ELK1(1), EXOC7(2), FASN(3), FBP2(2), FOXO1(2), G6PC2(6), GRB2(1), GYS2(2), IKBKB(2), INSR(2), IRS1(2), IRS2(2), IRS4(6), LIPE(2), MAP2K1(2), MAPK8(1), MKNK1(1), MKNK2(3), PCK1(3), PCK2(1), PDPK1(1), PFKM(1), PHKA1(1), PHKB(2), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PRKAA1(1), PRKACA(1), PRKACG(2), PRKAG3(4), PRKX(1), PTPN1(1), PTPRF(1), PYGB(6), PYGL(4), RAF1(4), RAPGEF1(1), RPS6KB2(5), SHC2(1), SHC3(1), SLC2A4(1), SOCS1(9), SOCS3(1), SORBS1(4), SOS1(1), SOS2(1), SREBF1(1), TRIP10(1), TSC1(4)	11725086	143	28	120	274	39	55	4	30	15	0	1.000	1.000	1.000
78	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(1), ADAM17(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), CHUK(1), CSK(3), EGFR(4), IGSF5(4), IKBKB(2), LYN(2), MAP2K4(1), MAPK11(1), MAPK8(1), MET(2), NFKB1(3), NFKB2(3), NFKBIA(3), NOD1(3), PLCG1(3), PLCG2(5), PTPRZ1(13), RAC1(1), TCIRG1(2), TJP1(3)	5259254	76	28	64	95	23	18	7	17	11	0	1.000	1.000	1.000
79	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT2(1), CDKN1B(1), CDKN2A(1), ERBB4(4), F2RL2(1), GAB1(1), GRB2(1), IGFBP1(2), INPPL1(1), IRS1(2), IRS2(2), IRS4(6), MET(2), MYC(7), NOLC1(2), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PARD3(2), PIK3CA(2), PIK3CD(1), PREX1(8), PTEN(2), PTK2(2), PTPN1(1), RPS6KA1(2), RPS6KA2(1), SFN(2), SLC2A4(1), SOS1(1), SOS2(1), TSC1(4), YWHAE(1)	5630802	88	28	68	130	15	29	6	29	9	0	1.000	1.000	1.000
80	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), AKAP1(4), AKAP10(3), AKAP11(5), AKAP12(10), AKAP2(5), AKAP3(4), AKAP4(3), AKAP5(2), AKAP6(8), AKAP7(3), AKAP9(8), ARHGEF1(1), GNA13(2), GNA14(1), GNAI2(2), GNB3(1), GNGT1(1), IL18BP(1), ITPR1(4), KCNJ3(1), PALM2(1), PDE1B(1), PDE1C(5), PDE4A(3), PDE4C(2), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), PRKD3(2), RHOA(2)	8544817	117	27	102	182	27	48	5	29	7	1	1.000	1.000	1.000
81	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(4), ALG6(4), CCKBR(1), CCR2(3), CCR3(1), CELSR1(21), CELSR2(1), CELSR3(3), CHRM3(5), CIDEB(1), EDNRA(1), EMR2(4), EMR3(4), F2R(1), FSHR(5), GHRHR(2), GPR116(5), GPR133(4), GPR18(1), GPR55(3), GPR56(4), GRM1(2), HRH4(3), LGR6(3), LPHN2(3), LPHN3(1), P2RY11(3), P2RY13(1), PTGFR(1), SMO(2), SSTR2(1), TSHR(3)	4857309	101	27	81	109	21	35	7	37	1	0	1.000	1.000	1.000
82	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(3), ANAPC1(3), ANAPC4(3), ATM(8), ATR(6), BUB1(1), BUB1B(1), CCNA1(1), CCNB2(2), CCNB3(1), CCND1(1), CCND2(2), CCND3(3), CDC14A(1), CDC16(3), CDC25C(4), CDC6(5), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), CHEK2(2), CREBBP(7), CUL1(2), DBF4(2), E2F1(2), E2F2(3), E2F3(1), EP300(5), ESPL1(12), FZR1(1), HDAC2(2), MAD1L1(3), MAD2L1(1), MCM3(2), MCM4(2), MCM7(2), PKMYT1(2), PLK1(1), RB1(1), RBL2(3), SFN(2), SKP1(1), SKP2(1), SMAD3(1), SMC1B(8), TGFB2(1), YWHAE(1)	9829778	126	27	101	124	32	44	2	32	14	2	1.000	1.000	1.000
83	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(4), C1S(4), C3(5), C4A(6), C4B(2), C4BPA(4), C5(6), C6(3), C7(7), C8A(9), C8B(3), C9(2), CFB(2), CFH(4), CFI(2), CPB2(2), CR2(7), F10(1), F11(1), F12(1), F13A1(8), F13B(1), F2(1), F2R(1), F5(18), F7(3), F8(3), F9(1), FGA(2), FGB(1), FGG(1), KLKB1(4), KNG1(6), MASP1(1), MASP2(4), MBL2(4), PLAT(1), PLG(4), PROC(2), PROS1(1), SERPINA1(3), SERPINA5(6), SERPINC1(1), SERPIND1(2), SERPINE1(1), SERPINF2(8), SERPING1(1), THBD(1), VWF(11)	7331727	176	27	130	166	42	81	0	45	8	0	1.000	1.000	1.000
84	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(2), INPP5B(4), INPPL1(1), ITPKA(1), ITPKB(10), OCRL(1), PI4KA(4), PIK3C3(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PTEN(2), SYNJ1(2), SYNJ2(3)	5487270	82	26	70	136	17	26	6	18	15	0	1.000	1.000	1.000
85	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(2), ALG1(6), ALG10(1), ALG11(1), ALG12(1), ALG14(2), ALG3(1), ALG6(4), ALG8(3), ALG9(1), B3GNT1(1), B3GNT6(1), B3GNT7(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), B4GALT5(1), C1GALT1C1(1), CHST11(1), CHST12(4), CHST13(2), CHST2(1), CHST4(2), CHST6(1), CHSY1(3), DPAGT1(2), EXT1(1), EXT2(1), EXTL1(2), EXTL3(1), FUT8(4), GALNT1(1), GALNT10(1), GALNT12(1), GALNT2(2), GALNT4(5), GALNT5(1), GALNT6(1), GALNT8(8), GALNT9(1), GANAB(3), GCNT1(4), GCNT4(2), HS3ST1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(3), HS6ST2(1), HS6ST3(2), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(1), MGAT1(6), MGAT4A(2), MGAT5(1), MGAT5B(2), NDST1(1), NDST3(1), RPN2(1), ST6GAL1(3), ST6GALNAC1(3), STT3B(1), UST(1), WBSCR17(1), XYLT1(4), XYLT2(5)	8073853	132	26	110	171	27	48	5	46	6	0	1.000	1.000	1.000
86	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AKT2(1), ATM(8), BCL2(1), BIRC2(1), CAPN2(4), CASP10(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), CSF2RB(3), DFFA(1), ENDOG(2), IKBKB(2), IL1A(2), IL1R1(1), IL3(3), IL3RA(4), IRAK1(3), IRAK2(5), IRAK3(1), NFKB1(3), NFKB2(3), NFKBIA(3), NTRK1(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1)	6035336	102	26	77	113	16	39	1	37	9	0	1.000	1.000	1.000
87	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(3), CPEB1(1), EGFR(4), ERBB2(3), ERBB4(4), ETS1(1), ETS2(2), ETV6(1), ETV7(2), FMN2(14), GRB2(1), MAP2K1(2), NOTCH1(2), NOTCH2(10), NOTCH3(5), NOTCH4(10), PIWIL1(4), PIWIL3(2), PIWIL4(6), RAF1(4), SOS1(1), SOS2(1), SPIRE2(1)	3884971	84	26	63	97	15	32	2	27	7	1	1.000	1.000	1.000
88	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADRB1(1), DRD2(1), EGF(4), EGFR(4), GJA1(1), GJD2(1), GNAI2(2), GNAS(1), GRB2(1), GRM1(2), GRM5(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), HTR2A(2), HTR2C(1), ITPR1(4), ITPR2(3), ITPR3(2), MAP2K1(2), MAPK7(1), NPR1(2), NPR2(1), PDGFC(1), PDGFRB(2), PLCB1(8), PLCB3(2), PLCB4(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKG1(3), PRKG2(1), PRKX(1), RAF1(4), SOS1(1), SOS2(1), TJP1(3), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5)	9600654	125	26	107	243	35	41	3	29	17	0	1.000	1.000	1.000
89	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	105	ACTN1(3), ACTN2(1), ACTN4(1), ARHGAP5(2), BCAR1(2), CD99(3), CLDN18(1), CLDN22(2), CLDN5(2), CTNNA2(3), CTNNA3(6), CTNND1(1), CYBA(1), CYBB(1), EZR(1), GNAI2(2), ICAM1(6), ITGA4(5), ITGAL(1), ITGAM(6), MAPK11(1), MLLT4(1), MMP2(1), MMP9(3), MSN(2), NCF1(1), NCF2(2), NOX3(2), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PRKCG(2), PTK2(2), PTK2B(4), RAC1(1), RAPGEF3(8), RHOA(2), ROCK2(2), SIPA1(3), TXK(4), VAV1(3), VAV2(3), VAV3(4), VCAM1(1)	9036327	118	26	94	182	31	28	9	32	17	1	1.000	1.000	1.000
90	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	BRAF(3), CACNA1A(3), CRHR1(1), GNA13(2), GNAI2(2), GNAS(1), GRIA2(3), GRID2(5), GRM1(2), GRM5(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), ITPR1(4), ITPR2(3), ITPR3(2), LYN(2), MAP2K1(2), NOS1(3), NPR1(2), NPR2(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCB1(8), PLCB3(2), PLCB4(2), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCG(2), PRKG1(3), PRKG2(1), RAF1(4), RYR1(4)	8102911	89	26	81	204	25	26	4	21	13	0	1.000	1.000	1.000
91	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ATF4(4), CACNA1C(8), CACNA1F(6), CACNA1S(8), CAMK2G(1), EGFR(4), ELK1(1), GNAS(1), GNRH1(3), GNRH2(2), GRB2(1), ITPR1(4), ITPR2(3), ITPR3(2), LHB(3), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K4(1), MAPK11(1), MAPK7(1), MAPK8(1), MMP14(4), MMP2(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCB1(8), PLCB3(2), PLCB4(2), PLD1(4), PLD2(13), PRKACA(1), PRKACG(2), PRKCD(1), PRKX(1), PTK2B(4), RAF1(4), SOS1(1), SOS2(1)	9645542	142	26	115	240	35	44	9	32	22	0	1.000	1.000	1.000
92	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT2(1), BCR(1), BTK(2), CD19(2), CSK(3), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(10), LYN(2), MAP2K1(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PIK3CA(2), PIK3CD(1), PLCG2(5), RAF1(4), SOS1(1), SOS2(1), VAV1(3)	3844130	54	26	49	87	16	15	2	11	10	0	1.000	1.000	1.000
93	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BFAR(4), BTK(2), CAD(1), CASP10(2), CASP8(3), CSNK1A1(2), DFFA(1), EGFR(4), EPHB2(1), FAF1(1), IL1A(2), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MET(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PFN1(3), PTPN13(8), RALBP1(1), TNFRSF6B(1), TPX2(1), TUFM(1)	5411995	65	26	57	95	14	22	3	18	8	0	1.000	1.000	1.000
94	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	139	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADSS(1), ADSSL1(3), AK1(1), AK2(2), AK5(1), AK7(3), AMPD3(3), ATIC(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD2(1), ENTPD3(3), ENTPD4(2), ENTPD5(2), ENTPD6(4), GART(3), GDA(2), GMPR(1), GMPS(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), NPR1(2), NPR2(1), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), NUDT5(1), NUDT9(1), PAICS(2), PAPSS1(5), PAPSS2(1), PDE10A(1), PDE11A(3), PDE1C(5), PDE2A(1), PDE4A(3), PDE4C(2), PDE5A(2), PDE6H(1), PDE9A(4), PFAS(6), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4), PRIM1(1), PRPS1L1(2), PRUNE(1), RFC5(1), RRM1(1), XDH(6)	11828384	148	25	120	255	41	46	6	45	10	0	1.000	1.000	1.000
95	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	95	AKT2(1), CASP8(3), CD80(2), CD86(1), CHUK(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), IFNAR1(4), IFNAR2(3), IKBKB(2), IKBKE(4), IL12B(2), IL6(2), IRAK1(3), IRF3(3), IRF5(1), IRF7(2), LBP(8), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAPK11(1), MAPK8(1), NFKB1(3), NFKB2(3), NFKBIA(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), RAC1(1), SPP1(1), STAT1(1), TIRAP(5), TLR1(5), TLR2(2), TLR3(2), TLR4(2), TLR5(4), TLR6(1), TLR7(1), TLR8(2), TNF(3), TRAF3(4), TRAF6(1)	6483650	118	25	100	135	26	43	8	31	10	0	1.000	1.000	1.000
96	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(3), INPP4B(5), INPP5A(2), INPPL1(1), ITPKA(1), ITPKB(10), OCRL(1), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3CA(2), PIK3CG(3), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCG1(3), PLCG2(5)	3347357	64	25	53	98	15	14	4	18	13	0	1.000	1.000	1.000
97	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(1), BCL2(1), BCR(1), BTK(2), CD19(2), CD22(2), CR2(7), CSK(3), GRB2(1), ITPR1(4), ITPR2(3), ITPR3(2), LYN(2), MAP4K1(1), NFATC1(6), NFATC2(2), PIK3CA(2), PIK3CD(1), PLCG2(5), PPP3CA(1), PPP3CC(1), PTPRC(1), RAF1(4), SOS1(1), SOS2(1), VAV1(3)	5419191	60	25	54	132	13	22	1	15	9	0	1.000	1.000	1.000
98	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	32	AKT2(1), ASAH1(4), BRAF(3), DRD2(1), EGFR(4), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PITX2(1), PLCB1(8), PLCB3(2), PLCB4(2), RAF1(4), SOS1(1), SOS2(1), TERF2IP(1)	4183555	59	25	50	103	14	22	1	11	11	0	1.000	1.000	1.000
99	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(2), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(11), PIK3CA(2), PLA2G4A(1), PLCG1(3), PPP3CA(1), PPP3CC(1), RAF1(4), SOS1(1), VAV1(3)	3140558	54	24	42	63	8	17	8	16	5	0	1.000	1.000	1.000
100	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	51	AKR1C4(4), ARSE(1), CYP11B1(3), CYP11B2(5), HEMK1(1), HSD17B1(2), HSD17B12(2), HSD17B7(4), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1), SULT2B1(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4)	3291694	81	24	59	92	16	29	3	28	5	0	1.000	1.000	1.000
101	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT2(1), BTK(2), CSF2(1), GRB2(1), IL3(3), LCP2(1), LYN(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAPK11(1), MAPK8(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PRKCD(1), RAC1(1), RAC3(1), RAF1(4), SOS1(1), SOS2(1), TNF(3), VAV1(3), VAV2(3), VAV3(4)	5223246	65	24	59	129	14	24	7	13	7	0	1.000	1.000	1.000
102	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(12), ACSL3(2), ACSL5(2), ADIPOQ(2), ADIPOR2(1), AKT2(1), CAMKK1(1), CAMKK2(5), CD36(1), CHUK(1), CPT1B(4), CPT1C(1), CPT2(5), G6PC2(6), IKBKB(2), IRS1(2), IRS2(2), IRS4(6), JAK1(2), JAK2(2), JAK3(2), LEPR(10), MAPK8(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NPY(1), PCK1(3), PCK2(1), POMC(2), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAG3(4), PRKCQ(2), SLC2A4(1), SOCS3(1), STK11(1), TNF(3), TNFRSF1B(3), TYK2(3)	6035220	112	24	84	148	32	32	10	29	9	0	1.000	1.000	1.000
103	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	AGT(4), CALR(1), CAMK1G(1), CAMK4(1), CREBBP(7), CSNK1A1(2), ELSPBP1(11), F2(1), GATA4(2), MAP2K1(2), MAPK8(1), MEF2C(1), MYH2(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NKX2-5(1), NPPA(1), PIK3CA(2), PPP3CA(1), PPP3CC(1), PRKACG(2), RAF1(4)	3689530	58	24	46	65	24	12	4	13	5	0	1.000	1.000	1.000
104	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(7), APOA1(1), CD36(1), CPT1B(4), CREBBP(7), EHHADH(3), EP300(5), FABP1(2), HSD17B4(4), LPL(1), MYC(7), NCOA1(2), NCOR1(5), NCOR2(9), NFKBIA(3), NRIP1(3), PIK3CA(2), PPARA(1), PRKACG(2), PTGS2(1), RB1(1), SP1(1), TNF(3)	4739156	75	24	68	75	12	28	3	24	8	0	1.000	1.000	1.000
105	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT2(1), ANGPTL2(1), ARHGAP4(2), ARHGEF11(4), BTK(2), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(3), ITPR3(2), LIMK1(1), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PITX2(1), PTEN(2), RACGAP1(1), ROCK2(2), SAG(5), WASF1(1), WASL(1)	5210714	72	24	56	103	20	18	7	23	4	0	1.000	1.000	1.000
106	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ANGPTL2(1), FLNA(4), FLNC(7), GDI1(1), LIMK1(1), MYH2(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PFN1(3), ROCK2(2), WASF1(1), WASL(1)	3516548	54	24	39	64	12	13	6	21	2	0	1.000	1.000	1.000
107	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	ASAH1(4), ATF1(1), BRAF(3), CREBBP(7), EGR1(1), EGR2(1), EGR4(1), ELK1(1), MAP1B(4), MAP2K4(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), NTRK1(3), OPN1LW(7), PIK3C2G(10), PIK3CA(2), PIK3CD(1), TERF2IP(1), TH(3)	3905858	56	24	48	62	13	22	2	14	5	0	1.000	1.000	1.000
108	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(1), ACTN4(1), DES(2), DMD(8), MYBPC1(3), MYBPC2(10), MYBPC3(4), MYH3(1), MYH6(6), MYH7(1), MYH8(5), MYOM1(13), NEB(16), TMOD1(1), TNNT1(1), TPM1(1), TPM2(1), TTN(121)	10289363	196	24	137	172	64	76	8	34	14	0	1.000	1.000	1.000
109	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1G(1), ELK1(1), FPR1(8), GNGT1(1), MAP2K1(2), MAP2K3(4), MAP3K1(7), NCF1(1), NCF2(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIA(3), PIK3C2G(10), PLCB1(8), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(4)	2892818	68	23	55	62	16	15	4	20	13	0	1.000	1.000	1.000
110	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	BCL2(1), BIRC2(1), CASP2(1), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), GSN(4), LMNA(3), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKBIA(3), NUMA1(2), PAK2(11), PRKCD(1), PSEN1(1), PTK2(2), RASA1(2), RB1(1), SPTAN1(1), TNF(3), TNFRSF1B(3), TRAF1(2)	5125987	66	23	49	96	11	18	5	23	9	0	1.000	1.000	1.000
111	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	65	ADH4(4), ADH7(2), ADHFE1(1), AKR1C1(2), AKR1C2(2), AKR1C3(3), AKR1C4(4), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), CYP1A1(2), CYP1A2(2), CYP1B1(2), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2F1(9), CYP2S1(1), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), DHDH(8), EPHX1(6), GSTA3(2), GSTA4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4)	3903798	141	23	105	113	21	44	4	54	17	1	1.000	1.000	1.000
112	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT2(1), BCR(1), BTK(2), CD19(2), CDKN2A(1), GAB1(1), ITPR1(4), ITPR2(3), ITPR3(2), LYN(2), PIK3CA(2), PITX2(1), PLCG2(5), PREX1(8), PTEN(2), PTPRC(1), RPS6KA1(2), RPS6KA2(1), SAG(5), TEC(2), VAV1(3)	4072491	51	23	43	120	13	13	2	13	10	0	1.000	1.000	1.000
113	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(4), AR(6), ASAH1(4), BRAF(3), CCL15(1), EGFR(4), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PIK3CA(2), PIK3CD(1), PITX2(1), PTX3(3), RAF1(4)	3963767	57	23	48	92	12	22	2	14	7	0	1.000	1.000	1.000
114	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(8), CCNA1(1), CCND1(1), CCND2(2), CCND3(3), CCNG2(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), CREB3L1(2), CREB3L4(2), E2F1(2), E2F2(3), E2F3(1), GBA2(1), MCM3(2), MCM4(2), MCM7(2), MYC(7), MYT1(1), NACA(7), POLA2(1), POLE(4), PRIM1(1), RB1(1), TFDP2(1), TNXB(14)	5571334	77	22	64	93	16	27	4	24	6	0	1.000	1.000	1.000
115	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT1(1), AGPAT2(1), CDS1(1), CDS2(1), CHAT(4), CHKA(1), CHPT1(2), CRLS1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), ESCO1(1), ETNK2(1), GNPAT(2), GPAM(5), GPD1(1), GPD1L(1), GPD2(3), LCAT(1), LYPLA1(1), LYPLA2(1), PCYT1B(1), PEMT(4), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLD1(4), PLD2(13), PNPLA3(5), PPAP2B(1), PTDSS2(2)	4960637	86	22	68	88	17	30	5	27	7	0	1.000	1.000	1.000
116	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPL(2), ALPP(13), ALPPL2(5), ASCC3(5), ATP13A2(1), DDX18(2), DDX23(1), DDX41(2), DDX47(2), DDX51(6), DDX52(4), DDX54(2), DDX55(3), DHX58(5), ENTPD7(3), EP400(7), ERCC2(4), FPGS(2), GCH1(1), GGH(3), IFIH1(7), MOV10L1(17), NUDT5(1), RAD54B(2), SETX(8), SKIV2L2(2), SMARCA2(8), SMARCA5(1)	4657327	119	22	84	115	30	41	7	31	10	0	1.000	1.000	1.000
117	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP7(1), BMP8A(1), BTRC(1), CSNK1A1(2), CSNK1A1L(5), CSNK1E(1), CSNK1G3(1), GLI1(2), GLI2(6), GLI3(3), LRP2(16), PRKACA(1), PRKACG(2), PRKX(1), PTCH1(4), PTCH2(3), RAB23(1), SHH(1), SMO(2), STK36(11), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2)	4469825	83	22	68	100	25	23	4	25	6	0	1.000	1.000	1.000
118	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), CHUK(1), EGF(4), EGFR(4), ETS1(1), ETS2(2), IKBKB(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKBIA(3), PPP2CA(1), PRKCD(1), PRKCG(2), PRKCQ(2), RAF1(4), SP1(1), TNF(3), TNFRSF1B(3)	3455633	54	22	48	80	12	21	5	9	7	0	1.000	1.000	1.000
119	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(1), CREBBP(7), EP300(5), IKBKB(2), MAP2K3(4), MAPK11(1), NFKB1(3), NFKBIA(3), TLR2(2), TNF(3)	2139291	31	22	29	23	6	7	1	8	9	0	0.998	1.000	1.000
120	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(7), AR(6), ESR2(1), NR0B1(2), NR1H2(2), NR2F2(1), PGR(7), PPARA(1), PPARG(3), RARB(1), RARG(1), ROR1(1), THRA(1), THRB(2), VDR(2)	3152858	38	22	29	77	6	9	3	12	8	0	1.000	1.000	1.000
121	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	63	AGTR1(2), AGTR2(3), ATP8A1(2), AVPR1B(3), CCKBR(1), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CXCR6(1), EDNRA(1), FPR1(8), FSHR(5), GALR1(3), GALR2(1), GALR3(1), GALT(2), GHSR(1), MC1R(4), MC3R(2), MC5R(1), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OXTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6), TACR2(4), TACR3(1), TSHR(3)	3574002	75	22	62	95	12	26	4	29	4	0	1.000	1.000	1.000
122	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	107	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADSS(1), AK1(1), AK2(2), AK5(1), AMPD3(3), ATIC(1), ATP5F1(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD2(1), GART(3), GDA(2), GMPS(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), NPR1(2), NPR2(1), NT5C(1), NT5E(2), NT5M(1), PAICS(2), PAPSS1(5), PAPSS2(1), PDE4A(3), PDE4C(2), PDE5A(2), PDE6C(1), PDE9A(4), PFAS(6), POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15), POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4), PRPS1L1(2), PRUNE(1), RRM1(1)	9216390	114	22	96	192	26	37	6	36	9	0	1.000	1.000	1.000
123	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(4), CDR1(2), DGKI(5), IL6ST(4), MRPL19(3), PIGK(1), RPL13(1), RPL14(1), RPL3(1), RPL37(1), RPL3L(2), RPL4(1), RPL5(1), RPL6(1), RPLP2(1), RPS14(2), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1), RPS6KB2(5), SLC36A2(1), TBC1D10C(1), UBB(1)	3773565	43	22	39	93	6	18	1	10	8	0	1.000	1.000	1.000
124	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	25	AKT2(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PITX2(1), PLD1(4), PLD2(13)	3326898	49	22	37	75	13	11	3	11	11	0	1.000	1.000	1.000
125	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(4), CCND1(1), CCND2(2), CCND3(3), CSNK1E(1), DVL1(1), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), LDLR(3), MYC(7), PPP2R5E(1), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), RAC1(1), RHOA(2), SFRP4(2), TCF7(2), WNT10A(1), WNT16(4), WNT5A(1), WNT7B(1)	4287548	55	22	48	99	14	21	3	11	6	0	1.000	1.000	1.000
126	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	62	BCL2(1), BIRC2(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), GZMB(5), IKBKB(2), IRF1(3), IRF2(1), IRF3(3), IRF5(1), IRF7(2), MAP2K4(1), MAP3K1(7), MYC(7), NFKB1(3), NFKBIA(3), NFKBIB(1), PLEKHG5(2), PRF1(2), TNF(3), TNFRSF10B(4), TNFRSF1B(3), TNFRSF21(1), TP73(1), TRAF1(2), TRAF3(4)	4062277	81	21	67	89	17	26	5	23	10	0	1.000	1.000	1.000
127	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	26	BRCA1(12), CCND1(1), CREBBP(7), EP300(5), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(3), HDAC2(2), HDAC6(2), MEF2C(1), NCOR2(9), NR0B1(2), NRIP1(3), PELP1(6), TBP(2)	3571992	58	21	48	66	14	18	5	13	8	0	1.000	1.000	1.000
128	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(3), ATM(8), BUB1(1), BUB1B(1), CCNA1(1), CCNB2(2), CCNB3(1), CCND2(2), CCND3(3), CDAN1(7), CDC14A(1), CDC25C(4), CDC6(5), CDH1(1), CDKN1A(4), CDKN2A(1), CHEK2(2), DTX4(2), E2F1(2), E2F2(3), E2F3(1), EP300(5), ESPL1(12), HDAC2(2), HDAC6(2), HDAC8(1), MAD1L1(3), MAD2L1(1), MCM3(2), MCM4(2), MCM7(2), MPEG1(6), PLK1(1), PTPRA(2), RB1(1), SKP2(1), TBC1D8(3)	8042470	101	21	80	104	27	37	5	20	11	1	1.000	1.000	1.000
129	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT1(1), AGPAT2(1), CDS1(1), CDS2(1), CHAT(4), CHKA(1), CLC(1), CPT1B(4), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), GNPAT(2), GPD1(1), GPD2(3), LCAT(1), LGALS13(1), LYPLA1(1), LYPLA2(1), PCYT1B(1), PEMT(4), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PPAP2B(1)	3794789	59	21	52	77	15	17	3	21	3	0	1.000	1.000	1.000
130	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(1), ADCY8(1), CACNA1A(3), CACNA1B(7), GNAS(1), GNAT3(1), GNB3(1), GRM4(1), ITPR3(2), KCNB1(1), PRKACA(1), PRKACG(2), PRKX(1), SCNN1A(3), SCNN1B(3), SCNN1G(2), TAS1R1(3), TAS1R2(10), TAS1R3(1), TAS2R1(3), TAS2R14(2), TAS2R16(3), TAS2R38(2), TAS2R39(1), TAS2R4(5), TAS2R40(1), TAS2R41(2), TAS2R42(6), TAS2R43(4), TAS2R46(3), TAS2R5(3), TAS2R50(3), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(12)	4332525	102	21	75	100	28	35	0	26	13	0	1.000	1.000	1.000
131	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CLK2(2), COL2A1(3), CPSF1(3), DDX20(9), DHX38(1), DHX9(1), DICER1(1), GIPC1(3), METTL3(1), NXF1(3), PRPF18(1), PRPF4(1), PRPF4B(3), PTBP1(1), PTBP2(1), RBM17(1), RBM5(1), RNGTT(1), SF3A2(1), SF3B1(5), SNRPD2(1), SNRPE(1), SPOP(1), SRPK1(1), SRRM1(2), SUPT5H(1)	7805498	51	21	44	144	9	24	1	7	10	0	1.000	1.000	1.000
132	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT2(1), BRD4(2), CBL(1), CDKN2A(1), F2RL2(1), GRB2(1), IGFBP1(2), INPPL1(1), IRS1(2), IRS2(2), IRS4(6), LNPEP(3), PARD3(2), PIK3CA(2), PIK3CD(1), PTEN(2), PTPN1(1), RAF1(4), RPS6KA1(2), RPS6KA2(1), SERPINB6(1), SFN(2), SLC2A4(1), SORBS1(4), SOS1(1), SOS2(1), YWHAE(1)	4329199	49	21	43	77	6	24	2	11	6	0	1.000	1.000	1.000
133	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3D(1), CD3G(2), ELK1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIA(3), PIK3CA(2), PLCG1(3), PPP3CA(1), PPP3CC(1), PTPN7(1), RAC1(1), RAF1(4), RASA1(2), SOS1(1), VAV1(3), ZAP70(1)	3519620	52	21	46	50	10	18	5	11	8	0	1.000	1.000	1.000
134	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(4), BTRC(1), CCND1(1), CREBBP(7), CSNK1A1(2), CSNK2A1(4), DVL1(1), FZD1(1), MYC(7), PPP2CA(1)	2234633	29	21	29	34	2	8	2	10	7	0	1.000	1.000	1.000
135	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(2), ASH2L(1), CTCFL(5), DOT1L(2), EHMT1(1), EHMT2(2), EZH2(7), JMJD4(3), KDM6A(1), MEN1(1), NSD1(6), PAXIP1(2), PPP1CA(1), PRDM2(7), PRDM6(3), PRDM7(7), PRMT6(2), PRMT8(1), SETD1A(1), SETD2(3), SETDB2(2), SETMAR(5), SMYD3(3), SUV39H1(1), SUV39H2(1), SUV420H1(1), SUV420H2(1), WHSC1(2), WHSC1L1(1)	8993290	75	20	59	77	15	27	6	25	2	0	1.000	1.000	1.000
136	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CD3D(1), CD3G(2), CREBBP(7), CSK(3), GNAS(1), GNGT1(1), HLA-DRA(2), HLA-DRB1(46), PRKACG(2), PTPRC(1), ZAP70(1)	1715091	67	20	52	46	9	22	2	27	7	0	1.000	1.000	1.000
137	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CD3D(1), CD3G(2), CREBBP(7), CSK(3), GNAS(1), GNGT1(1), HLA-DRA(2), HLA-DRB1(46), PRKACG(2), PTPRC(1), ZAP70(1)	1715091	67	20	52	46	9	22	2	27	7	0	1.000	1.000	1.000
138	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	DPM2(1), EGFR(4), ELK1(1), GNAS(1), GNGT1(1), GRB2(1), KLK2(1), MAP2K1(2), MKNK1(1), MKNK2(3), MYC(7), NGFR(2), PPP2CA(1), PTPRR(3), RAF1(4), RPS6KA1(2), RPS6KA5(1), SOS1(1)	2359550	37	20	35	53	8	15	3	9	2	0	1.000	1.000	1.000
139	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(1), CDA(2), CTPS2(1), DCK(1), DHODH(1), DPYD(9), DPYS(1), ENTPD3(3), ENTPD4(2), ENTPD5(2), ENTPD6(4), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4), PRIM1(1), RFC5(1), RRM1(1), UMPS(2), UPP1(1), UPP2(4)	6027791	66	20	54	137	20	22	2	21	1	0	1.000	1.000	1.000
140	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), AOX1(4), DBH(7), DCT(1), DDC(3), ECH1(2), ESCO1(1), FAH(1), GOT2(4), HEMK1(1), HGD(1), LCMT1(1), LCMT2(1), METTL2B(3), PNPLA3(5), PRMT2(1), PRMT6(2), PRMT8(1), TAT(2), TH(3), TPO(10), TYRP1(1)	4243444	75	20	60	85	24	26	1	19	5	0	1.000	1.000	1.000
141	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(3), ACADL(3), ACADM(1), ACOX1(7), ACOX2(1), ACOX3(1), ACSL3(2), ACSL5(2), ADIPOQ(2), ANGPTL4(4), APOA1(1), APOA5(2), AQP7(3), CD36(1), CPT1B(4), CPT1C(1), CPT2(5), CYP27A1(1), CYP4A22(19), CYP8B1(2), EHHADH(3), FABP1(2), FABP3(1), FABP6(2), FABP7(1), HMGCS2(1), ILK(1), LPL(1), OLR1(2), PCK1(3), PCK2(1), PDPK1(1), PLTP(1), PPARA(1), PPARG(3), SCD(2), SLC27A1(1), SLC27A2(2), SLC27A5(8), SLC27A6(2), SORBS1(4), UCP1(2)	4727761	110	20	83	98	29	33	7	36	5	0	1.000	1.000	1.000
142	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	ATM(8), ATR(6), CASP8(3), CASP9(4), CCNB2(2), CCNB3(1), CCND1(1), CCND2(2), CCND3(3), CCNG1(1), CCNG2(1), CD82(1), CDKN1A(4), CDKN2A(1), CHEK2(2), DDB2(1), GTSE1(6), IGFBP3(1), PERP(2), PTEN(2), SERPINB5(2), SERPINE1(1), SESN1(2), SFN(2), THBS1(5), TNFRSF10B(4), TP73(1)	4706514	69	20	53	76	9	32	2	20	5	1	1.000	1.000	1.000
143	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT2(1), CASP9(4), KDR(8), MAP2K1(2), MAPK11(1), MAPKAPK2(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PPP3CA(1), PPP3CC(1), PRKCG(2), PTGS2(1), PTK2(2), RAC1(1), RAC3(1), RAF1(4), SH2D2A(2), SHC2(1), SPHK1(1), SPHK2(1)	5390444	69	20	60	113	20	21	6	19	3	0	1.000	1.000	1.000
144	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2(1), CBL(1), E2F1(2), GRB2(1), IL2RA(1), IL2RB(2), IRS1(2), JAK1(2), JAK3(2), MYC(7), NMI(1), PIK3CA(2), PTPN6(4), RAF1(4), SOCS1(9), SOCS3(1), SOS1(1)	2671180	43	20	42	72	8	18	1	9	7	0	1.000	1.000	1.000
145	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(3), ACTN2(1), BCAR1(2), BCR(1), CAV1(1), CSK(3), GRB2(1), ITGA1(3), MAP2K1(2), MAPK8(1), PPP1R12B(1), PTK2(2), RAF1(4), SOS1(1), TLN1(6)	3511825	32	20	28	55	5	11	3	8	5	0	1.000	1.000	1.000
146	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	43	AGL(6), AMY2A(1), AMY2B(2), ENPP1(3), ENPP3(3), GAA(1), GANAB(3), GBE1(3), GUSB(1), GYS2(2), HK1(1), HK2(4), HK3(1), MGAM(12), PGM1(4), PGM3(1), PYGB(6), PYGL(4), SI(5), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2), UXS1(1)	4864598	93	20	68	99	13	32	4	36	8	0	1.000	1.000	1.000
147	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	BCL2(1), BIRC2(1), CASP2(1), CASP7(3), CASP8(3), CASP9(4), GZMB(5), MAP2K4(1), MAP3K1(7), MCL1(1), MYC(7), NFKB1(3), NFKBIA(3), PARP1(2), PRF1(2), TNF(3), TNFRSF1B(3), TRAF1(2)	2667773	52	19	42	65	9	14	5	18	6	0	1.000	1.000	1.000
148	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	BCL2(1), BCL2A1(7), BOK(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), IKBKE(4), MCL1(1), NFKB1(3), NFKBIA(3), NGFR(2), NTRK1(3), PTPN13(8), TFG(1), TNF(3), TNFRSF1B(3), TRAF1(2), TRAF3(4), TRAF6(1)	3144823	64	19	52	68	14	23	2	18	7	0	1.000	1.000	1.000
149	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(8), ATR(6), BRCA1(12), BRCA2(7), CHEK2(2), FANCA(20), FANCD2(2), FANCE(2), FANCF(1), FANCG(1), HUS1(1), RAD1(3), RAD17(1), RAD50(1)	3119235	67	19	45	50	14	32	5	13	2	1	1.000	1.000	1.000
150	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BTK(2), CD79A(2), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(4), SOS1(1), VAV1(3)	2756669	42	19	37	52	9	14	4	9	6	0	1.000	1.000	1.000
151	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C9(2), MASP1(1), MASP2(4), MBL2(4)	2551455	53	19	42	35	12	21	0	18	2	0	0.994	1.000	1.000
152	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(2), CASP7(3), CASP8(3), DFFA(1), FAF1(1), LMNA(3), MAP2K4(1), MAP3K1(7), MAPK8(1), PAK2(11), PTPN13(8), RB1(1), RIPK2(1), SPTAN1(1)	3154006	44	19	32	55	5	13	5	16	5	0	1.000	1.000	1.000
153	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(2), GHR(2), GRB2(1), INSR(2), IRS1(2), JAK2(2), MAP2K1(2), PIK3CA(2), PLCG1(3), PTPN6(4), RAF1(4), RPS6KA1(2), SLC2A4(1), SOCS1(9), SOS1(1)	2443030	39	19	37	53	4	17	3	8	7	0	1.000	1.000	1.000
154	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(1), IFNA1(2), IKBKB(2), IL1A(2), IL1R1(1), IL6(2), IRAK1(3), IRAK2(5), IRAK3(1), MAP2K3(4), MAP3K1(7), MAPK8(1), NFKB1(3), NFKBIA(3), TGFB2(1), TNF(3), TRAF6(1)	2137046	42	19	38	38	12	12	2	8	8	0	1.000	1.000	1.000
155	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(3), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(3), CHRM3(5), DRD2(1), DRD3(1), DRD5(5), HRH1(1), HRH2(1), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1)	1909000	35	19	32	47	5	8	4	17	1	0	1.000	1.000	1.000
156	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(1), CREBBP(7), EP300(5), IKBKB(2), NFKB1(3), NFKBIA(3), TNF(3), TNFRSF1B(3), TRAF6(1)	1696262	28	19	25	19	4	8	0	8	8	0	0.992	1.000	1.000
157	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ANGPTL2(1), DGKA(1), GCA(1), ITGA9(2), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), MAP2K1(2), PIK3C2G(10), PIK3CA(2), PIK3CD(1), RIPK3(4)	3472342	44	19	37	83	13	8	2	14	7	0	1.000	1.000	1.000
158	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), DLG4(1), EPHB2(1), F2(1), F2RL2(1), F2RL3(1), MAPK7(1), MAPK8(1), PLD1(4), PLD2(13), PTK2(2), RAF1(4), RASAL1(4), TEC(2), VAV1(3)	2044240	41	19	30	30	8	12	4	9	8	0	0.993	1.000	1.000
159	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	32	AKT2(1), ARHGEF11(4), BCL2(1), DLG4(1), GNA13(2), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PLD1(4), PLD2(13), PTK2(2), ROCK2(2)	3420407	50	19	39	48	11	12	6	12	9	0	1.000	1.000	1.000
160	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	CASP2(1), CASP8(3), DFFA(1), LMNA(3), MAP2K4(1), MAP3K1(7), MAPK8(1), PAK2(11), RB1(1), SPTAN1(1), TNF(3)	2692723	33	19	24	47	3	8	5	11	6	0	1.000	1.000	1.000
161	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(1), ELK1(1), IKBKB(2), IRAK1(3), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), NFKB1(3), NFKBIA(3), PPARA(1), TIRAP(5), TLR10(5), TLR2(2), TLR3(2), TLR4(2), TLR6(1), TLR7(1), TRAF6(1)	2696002	46	19	41	42	10	18	3	9	6	0	1.000	1.000	1.000
162	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(4), ARSB(5), ARSE(1), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2)	1875162	51	18	35	58	14	14	3	19	1	0	1.000	1.000	1.000
163	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	28	ACP2(3), ACP5(1), ALPL(2), ALPP(13), ALPPL2(5), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A7(8), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2D6(11), CYP2E1(1), CYP2F1(9), CYP2J2(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(4), PON1(6)	2006935	100	18	73	51	29	28	3	31	9	0	0.936	1.000	1.000
164	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	38	ALDOB(1), ALDOC(1), FBP2(2), FPGT(1), FUK(3), GMPPB(2), HK1(1), HK2(4), HK3(1), HSD3B7(2), MTMR1(3), MTMR2(4), PFKM(1), PHPT1(1), PMM2(1), SORD(5)	2686025	33	18	28	76	9	9	0	13	2	0	1.000	1.000	1.000
165	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH4(4), ADH7(2), ADHFE1(1), AGPAT1(1), AGPAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CEL(4), DAK(2), DGAT1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), GLB1(1), GPAM(5), LCT(3), LIPA(3), LIPC(3), LIPF(2), LPL(1), PNLIPRP1(4), PNPLA3(5), PPAP2B(1)	4322113	77	18	63	106	9	28	4	28	8	0	1.000	1.000	1.000
166	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	AKR1C3(3), ALOX12(3), ALOX12B(1), ALOX15(2), ALOX15B(6), CBR3(4), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2J2(1), CYP4A22(19), CYP4F2(4), CYP4F3(1), EPHX2(6), GGT1(6), GPX5(1), LTA4H(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PTGES2(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5)	2841469	101	18	73	69	28	27	10	30	6	0	1.000	1.000	1.000
167	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(2), ACACB(12), ACAT1(2), ACAT2(1), ACOT12(3), ACSS1(2), ACSS2(1), ACYP1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DLAT(1), GLO1(2), GRHPR(4), LDHA(1), LDHAL6A(2), LDHAL6B(7), MDH2(5), ME2(2), ME3(2), PC(1), PCK1(3), PCK2(1), PDHA2(2)	3395782	71	18	57	91	21	27	3	17	3	0	1.000	1.000	1.000
168	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	38	ALAD(2), ALAS2(1), BLVRA(1), COX10(3), CP(1), CPOX(1), EPRS(2), GUSB(1), MMAB(5), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), UROS(1)	2742147	63	18	45	77	11	16	1	33	2	0	1.000	1.000	1.000
169	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(7), EP300(5), IL7R(7), JAK1(2), JAK3(2), NMI(1), PIK3CA(2), PTK2B(4)	2069090	31	18	25	38	7	12	0	6	6	0	1.000	1.000	1.000
170	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CSF1(2), CSF2(1), HLA-DRA(2), HLA-DRB1(46), IFNA1(2), IL11(1), IL12B(2), IL1A(2), IL3(3), IL6(2), TGFB2(1), TNF(3)	971495	67	18	49	42	11	26	3	24	3	0	0.988	1.000	1.000
171	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	DOCK1(7), ELK1(1), GAB1(1), GRB2(1), ITGA1(3), MAP2K1(2), MAP4K1(1), MAPK8(1), MET(2), PIK3CA(2), PTEN(2), PTK2(2), PTK2B(4), RAF1(4), RASA1(2), SOS1(1)	3225592	36	18	31	72	3	18	2	6	7	0	1.000	1.000	1.000
172	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(8), CCND2(2), CDKN1B(1), EGR1(1), ESR2(1), FSHR(5), GJA4(5), INHA(4), MLH1(5), MSH5(4), NCOR1(5), NRIP1(3), PGR(7), PRLR(2), VDR(2), ZP2(3)	2444207	58	18	45	44	4	35	1	17	1	0	0.998	1.000	1.000
173	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(3), ALOX15(2), CBR3(4), CYP4F2(4), CYP4F3(1), EPX(3), GGT1(6), LPO(2), LTA4H(2), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PTGES2(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5), TPO(10)	2096266	58	18	46	61	15	16	4	22	1	0	1.000	1.000	1.000
174	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	29	ARHGAP4(2), ARHGAP5(2), ARHGAP6(2), ARHGEF1(1), ARHGEF11(4), ARHGEF5(8), ARPC1B(3), GSN(4), LIMK1(1), MYLK(8), PFN1(3), PIP5K1A(1), PIP5K1B(1), PPP1R12B(1), TLN1(6)	3450227	47	18	36	25	9	12	3	14	9	0	0.906	1.000	1.000
175	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAP2K4(1), MAPK11(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MAPKAPK5(2), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PIK3CA(2), PIK3CD(1), TRAF3(4), TRAF6(1)	2611810	28	18	25	29	7	10	2	4	5	0	1.000	1.000	1.000
176	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(4), ASAH1(4), CERK(2), CXCL2(1), EPHB2(1), ITPKA(1), ITPKB(10), MAP2K4(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2)	2114383	29	18	23	32	5	13	2	6	3	0	1.000	1.000	1.000
177	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	34	ANKHD1(3), EEF1B2(1), EEF2K(3), EIF2AK1(2), EIF2AK2(1), EIF2B3(2), EIF2B4(2), EIF2B5(4), EIF2S2(1), EIF2S3(2), EIF4A2(1), EIF4G1(2), EIF4G3(2), EIF5B(2)	2932344	28	18	26	47	2	7	4	12	3	0	1.000	1.000	1.000
178	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF2B3(2), EIF2B4(2), EIF2B5(4), EIF2S2(1), EIF2S3(2), ELAVL1(1), FLT1(2), FLT4(5), KDR(8), PIK3CA(2), PLCG1(3), PTK2(2)	2546146	35	18	30	40	5	13	3	14	0	0	1.000	1.000	1.000
179	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(4), AGTR1(2), EGFR(4), ELK1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), MEF2B(3), MEF2C(1), PTK2(2), PTK2B(4), RAC1(1), RAF1(4), SOS1(1)	2511670	39	17	33	58	9	13	3	8	6	0	1.000	1.000	1.000
180	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(3), ATM(8), BRCA1(12), CDKN1A(4), CHEK2(2), MAPK8(1), NFKB1(3), NFKBIA(3), RAD50(1), TP73(1)	2095257	38	17	30	29	5	19	5	4	4	1	0.996	1.000	1.000
181	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	35	AGT(4), AGTR2(3), CAMK2G(1), F2(1), GNGT1(1), GRB2(1), JAK2(2), MAP2K1(2), MAPK8(1), MYLK(8), PLCG1(3), PTK2B(4), RAF1(4), SOS1(1), STAT1(1)	2881238	37	17	31	68	8	10	6	9	4	0	1.000	1.000	1.000
182	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), GNAS(1), GNGT1(1), LIMK1(1), MAP2K1(2), PIK3C2G(10), PLCB1(8), PPP1R12B(1), PTK2(2), RAF1(4), ROCK2(2)	1878938	34	17	29	28	9	7	1	10	7	0	1.000	1.000	1.000
183	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	MAP2K1(2), MYC(7), NFKB1(3), NFKBIA(3), PLCB1(8), RAF1(4), TNF(3)	1124288	30	17	27	28	2	8	2	8	10	0	1.000	1.000	1.000
184	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C9(2)	2264301	44	17	34	32	8	18	0	17	1	0	0.997	1.000	1.000
185	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C8B(3), C9(2), MASP1(1)	2500893	48	17	37	32	8	21	0	18	1	0	0.993	1.000	1.000
186	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(2), GSN(4), ITGA1(3), MAP2K1(2), MYLK(8), PFN1(3), PIK3CA(2), PTK2(2), RAF1(4), TLN1(6)	2752225	36	17	31	32	7	10	3	11	5	0	1.000	1.000	1.000
187	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(4), EGF(4), EGFR(4), ELK1(1), GRB2(1), JAK1(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1)	2629914	40	17	35	45	4	23	5	4	4	0	1.000	1.000	1.000
188	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), GOT2(4), HK1(1), HK2(4), HK3(1), LDHA(1), LDHAL6B(7), MDH2(5), PC(1), PCK1(3), PDHA2(2), PDHX(3), PFKM(1), PGAM2(1), PGK2(1)	3067490	43	17	32	82	10	19	2	9	3	0	1.000	1.000	1.000
189	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(1), ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH7A1(1), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), G6PC2(6), GALM(2), HK1(1), HK2(4), HK3(1), LDHA(1), LDHAL6A(2), LDHAL6B(7), PDHA2(2), PFKM(1), PGAM2(1), PGAM4(1), PGK2(1), PGM1(4), PGM3(1)	4254169	71	17	54	106	15	26	2	22	6	0	1.000	1.000	1.000
190	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	23	GUSB(1), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), XYLB(3)	1697223	47	17	33	51	4	12	1	28	2	0	1.000	1.000	1.000
191	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	111	ATP12A(3), ATP4A(1), ATP5F1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), COX10(3), COX4I2(2), COX7B(1), NDUFA2(1), NDUFA9(1), NDUFS1(1), NDUFS2(3), NDUFS4(1), NDUFS7(1), PPA2(4), SDHA(6), SDHC(1), TCIRG1(2), UQCRC1(1), UQCRH(2)	4129190	49	17	40	81	18	11	1	16	3	0	1.000	1.000	1.000
192	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	40	ALG1(6), ALG10(1), ALG11(1), ALG12(1), ALG14(2), ALG3(1), ALG6(4), ALG8(3), ALG9(1), B4GALT2(1), B4GALT3(2), DOLPP1(1), DPAGT1(2), FUT8(4), GANAB(3), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(1), MGAT1(6), MGAT4A(2), MGAT5(1), MGAT5B(2), RFT1(1), RPN2(1), ST6GAL1(3), STT3B(1)	3102787	54	17	47	58	12	22	3	14	3	0	1.000	1.000	1.000
193	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(3), ANAPC4(3), BTRC(1), CDC16(3), CUL1(2), FZR1(1), ITCH(1), SKP1(1), SKP2(1), SMURF1(1), SMURF2(1), UBA1(2), UBE2D3(1), UBE2E3(1), WWP2(1)	2914376	23	17	20	48	7	6	0	3	6	1	1.000	1.000	1.000
194	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT2(1), BRAF(3), PDPK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PRKAA1(1), RICTOR(4), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1), RPS6KB2(5), STK11(1), TSC1(4), ULK1(3), ULK2(1), ULK3(3), VEGFB(1), VEGFC(2)	4010905	42	17	36	76	11	15	1	8	7	0	1.000	1.000	1.000
195	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(2), AGT(4), AGTR1(2), AGTR2(3), ANPEP(4), CMA1(1), CTSG(1), ENPEP(2), LNPEP(3), MAS1(1), MME(4), NLN(4), THOP1(1)	1540715	34	17	32	17	8	11	1	10	4	0	0.811	1.000	1.000
196	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(3), ACTB(5), ARHGEF2(2), CDH1(1), CTTN(1), EZR(1), HCLS1(7), NCK1(2), NCL(4), RHOA(2), ROCK2(2), TLR4(2), TLR5(4), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5), WAS(1), WASL(1)	3720120	67	17	53	93	26	16	0	9	16	0	1.000	1.000	1.000
197	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(3), ACTB(5), ARHGEF2(2), CDH1(1), CTTN(1), EZR(1), HCLS1(7), NCK1(2), NCL(4), RHOA(2), ROCK2(2), TLR4(2), TLR5(4), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5), WAS(1), WASL(1)	3720120	67	17	53	93	26	16	0	9	16	0	1.000	1.000	1.000
198	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(4), ELK1(1), GRB2(1), IL6(2), IL6R(2), IL6ST(4), JAK1(2), JAK2(2), JAK3(2), MAP2K1(2), RAF1(4), SOS1(1)	1661946	27	17	26	27	6	12	1	5	3	0	1.000	1.000	1.000
199	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(5), C5(6), C6(3), C7(7), ICAM1(6), IL1A(2), IL6(2), ITGA4(5), ITGAL(1), SELP(6), TNF(3), VCAM1(1)	1741630	47	17	38	54	12	13	0	19	2	1	1.000	1.000	1.000
200	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(1), IKBKB(2), IL1A(2), IL1R1(1), IRAK1(3), MAP3K1(7), NFKB1(3), NFKBIA(3), TLR4(2), TNF(3), TNFRSF1B(3), TRAF6(1)	1691438	31	17	28	26	7	11	0	7	6	0	0.999	1.000	1.000
201	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	CAV1(1), CHRNA1(1), FLT1(2), FLT4(5), KDR(8), PDE2A(1), PRKACG(2), PRKG1(3), PRKG2(1), RYR2(9), SLC7A1(1)	2943726	34	17	28	53	3	13	1	16	1	0	1.000	1.000	1.000
202	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(2), ACAT1(2), ACAT2(1), ACYP1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DLAT(1), GLO1(2), GRHPR(4), LDHA(1), MDH2(5), ME2(2), ME3(2), PC(1), PCK1(3), PDHA2(2)	2693336	43	17	38	65	8	17	2	14	2	0	1.000	1.000	1.000
203	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(1), BCL2(1), GRB2(1), IL4R(15), IRS1(2), IRS2(2), JAK1(2), JAK3(2), MAP4K1(1), PIK3CA(2), PIK3CD(1), RAF1(4), SOCS1(9), SOS1(1), SOS2(1), STAT6(4)	2709873	49	17	41	60	8	24	6	6	5	0	1.000	1.000	1.000
204	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), APC(4), ASAH1(4), DLG4(1), EPHB2(1), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PITX2(1), PTX3(3), RAC1(1), RYR1(4)	3412968	33	17	29	108	8	10	3	10	2	0	1.000	1.000	1.000
205	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(1), CHUK(1), IKBKB(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), NFKB1(3), NFKBIA(3), TANK(2), TNF(3)	1811834	29	17	27	23	6	7	3	4	9	0	0.997	1.000	1.000
206	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	BCL2(1), EGFR(4), MYC(7), PPP2CA(1), RB1(1), TEP1(24), TERT(1), TNKS(2), XRCC5(2)	1969938	43	17	33	59	11	15	3	12	2	0	1.000	1.000	1.000
207	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(2), AOC3(4), AOX1(4), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A7(8), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2D6(11), CYP2E1(1), CYP2F1(9), CYP2J2(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(4), DDC(3), ECHS1(1), EHHADH(3), HAAO(1), KYNU(1), TDO2(1), WARS2(1)	3949468	108	17	88	76	31	36	2	29	10	0	1.000	1.000	1.000
208	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(4), AGTR1(2), AGTR2(3), CMA1(1), COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1)	1880144	44	16	35	38	11	12	1	15	5	0	0.999	1.000	1.000
209	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), ELK1(1), EPOR(1), GRB2(1), JAK2(2), MAP2K1(2), MAPK8(1), PLCG1(3), PTPN6(4), RAF1(4), SOS1(1)	1616140	24	16	23	17	2	10	4	4	4	0	0.971	1.000	1.000
210	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(8), ATR(6), BRCA1(12), CDC25C(4), CDKN1A(4), CHEK2(2), EP300(5), MYT1(1), RPS6KA1(2)	3083407	44	16	32	39	8	20	4	11	0	1	1.000	1.000	1.000
211	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH4(4), ADH7(2), ADHFE1(1), AGPAT1(1), AGPAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), CEL(4), DGAT1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), GLB1(1), LCT(3), LIPC(3), LIPF(2), LPL(1), PNLIPRP1(4), PPAP2B(1)	3556161	57	16	48	90	10	20	4	16	7	0	1.000	1.000	1.000
212	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	19	ADCYAP1R1(4), CALCR(5), CALCRL(2), CD97(2), CRHR1(1), ELTD1(7), EMR2(4), GHRHR(2), GIPR(1), GLP1R(3), GLP2R(3), LPHN1(1), LPHN2(3), LPHN3(1), SCTR(1), VIPR2(1)	1922050	41	16	32	34	8	13	5	14	1	0	0.999	1.000	1.000
213	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	APC(4), CCND1(1), DVL1(1), FZD1(1), GJA1(1), IRAK1(3), LBP(8), NFKB1(3), PDPK1(1), PIK3CA(2), PPP2CA(1), TIRAP(5), TLR4(2)	2258359	33	16	26	46	7	13	4	5	4	0	1.000	1.000	1.000
214	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS2(3), ACY3(1), ADSS(1), ADSSL1(3), AGXT(1), AGXT2(4), ASS1(1), CAD(1), DARS2(1), DDO(1), DLAT(1), GAD1(2), GAD2(1), GOT2(4), GPT(1), NARS2(1), PC(1), PDHA2(2)	2795367	30	16	26	49	10	6	2	12	0	0	1.000	1.000	1.000
215	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AASDHPPT(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DOT1L(2), ECHS1(1), EHHADH(3), EHMT1(1), EHMT2(2), HSD17B4(4), HSD3B7(2), NSD1(6), OGDH(2), OGDHL(3), PIPOX(1), PLOD1(2), PLOD2(2), SETD1A(1), SHMT1(3), SHMT2(1), SPCS1(1), SUV39H1(1), SUV39H2(1)	4219247	60	16	55	79	12	26	2	17	3	0	1.000	1.000	1.000
216	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(3), COASY(4), DPYD(9), DPYS(1), ENPP1(3), ENPP3(3), PANK1(1), PANK2(1), PANK4(5), VNN1(9)	1282087	39	16	28	19	4	15	5	13	2	0	0.805	1.000	1.000
217	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ELK1(1), GRB2(1), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPKAPK2(1), MAPKAPK5(2), MEF2B(3), MEF2C(1), MKNK1(1), MYC(7), PLA2G4A(1), RAC1(1), RPS6KA5(1), STAT1(1), TGFB2(1)	2755235	31	16	29	53	5	11	2	8	5	0	1.000	1.000	1.000
218	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(4), DPYD(9), DPYS(1), ENPP1(3), ENPP3(3), PANK1(1), PANK2(1), PANK4(5)	1032407	27	16	20	16	4	9	5	8	1	0	0.916	1.000	1.000
219	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(1), CDA(2), CTPS2(1), DCK(1), DHODH(1), DPYD(9), DPYS(1), NT5C(1), NT5E(2), NT5M(1), POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15), POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4), RRM1(1), UMPS(2), UPP1(1)	4277682	56	16	47	109	10	25	3	17	1	0	1.000	1.000	1.000
220	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5R1(1), LIMK1(1), MAP3K1(7), MYLK(8), NCF2(2), PIK3CA(2), PLD1(4), PPP1R12B(1), RAC1(1), RALBP1(1), TRIO(3), VAV1(3), WASF1(1)	2554515	35	16	29	32	9	8	4	11	3	0	1.000	1.000	1.000
221	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(1), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP3K1(7), MAPK8IP3(2), PAPPA(4), RAC1(1), RPS6KA1(2), SOS1(1), VAV1(3), VAV2(3), VAV3(4)	2369020	34	16	29	63	8	13	1	9	3	0	1.000	1.000	1.000
222	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	DUSP4(2), DUSP8(1), GAB1(1), IL1R1(1), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAPK7(1), MAPK8(1), NFATC3(1), PAPPA(4), TRAF6(1), ZAK(3)	3638958	29	16	26	54	11	7	2	8	1	0	1.000	1.000	1.000
223	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT2(1), ANKRD6(3), APC(4), AXIN2(4), CER1(4), CSNK1A1(2), DACT1(7), DKK2(2), DVL1(1), LRP1(6), MVP(2), NKD2(2), PSEN1(1), PTPRA(2), SENP2(1)	3007405	42	16	33	55	14	18	0	8	2	0	1.000	1.000	1.000
224	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRA(2), HLA-DRB1(46), IFNGR2(2), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), IL2RA(1), IL4R(15)	915108	80	16	54	48	10	31	8	27	4	0	0.995	1.000	1.000
225	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	30	ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), AOX1(4), DBH(7), DCT(1), DDC(3), FAH(1), GOT2(4), HGD(1), TAT(2), TH(3), TPO(10)	2226530	56	16	44	65	21	17	1	13	4	0	1.000	1.000	1.000
226	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADL(3), ACADM(1), ACADSB(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DPYD(9), DPYS(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1)	2109652	51	15	42	40	10	22	1	14	4	0	1.000	1.000	1.000
227	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(1), F12(1), F13B(1), F2(1), F5(18), F7(3), F8(3), F9(1), FGA(2), FGB(1), FGG(1), PLAT(1), PLG(4), SERPINB2(4), SERPINE1(1), SERPINF2(8), VWF(11)	2379857	63	15	45	82	19	31	0	11	2	0	1.000	1.000	1.000
228	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(1), AGT(4), AGTR2(3), EDNRA(1), EGF(4), EGFR(4), MYC(7), NFKB1(3), PLCG1(3)	1453474	30	15	25	40	5	10	3	10	2	0	1.000	1.000	1.000
229	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	ATM(8), BCL2(1), CASP7(3), CASP9(4), PTK2(2), STAT1(1), TLN1(6)	1934847	25	15	18	31	3	13	1	5	3	0	1.000	1.000	1.000
230	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	CD3D(1), CD3G(2), GZMB(5), HLA-A(93), ICAM1(6), ITGAL(1), PRF1(2)	609963	110	15	73	62	12	36	5	48	8	1	0.993	1.000	1.000
231	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(2), GNGT1(1), MAP2K1(2), NFKB1(3), PIK3C2G(10), PIK3CA(2), PLCG1(3), PTK2(2), PTK2B(4), RAF1(4)	2030655	33	15	27	46	8	9	3	7	6	0	1.000	1.000	1.000
232	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCL2(1), BCR(1), GRB2(1), JAK2(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), MYC(7), PIK3CA(2), RAF1(4), SOS1(1), STAT1(1)	2025614	31	15	30	46	3	14	4	8	2	0	1.000	1.000	1.000
233	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), HK1(1), HK2(4), HK3(1), LDHA(1), PDHA2(2), PFKM(1), PGM1(4), PGM3(1)	3563180	48	15	41	89	10	21	2	11	4	0	1.000	1.000	1.000
234	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	35	AGXT(1), AGXT2(4), ALAS2(1), AMT(1), AOC2(2), AOC3(4), BHMT(1), CBS(2), CHKA(1), CPT1B(4), CTH(2), DAO(2), DMGDH(4), GAMT(1), GARS(1), PEMT(4), PLCG1(3), PLCG2(5), SARDH(2), SARS(1), SHMT1(3), SHMT2(1)	3042478	50	15	42	74	18	16	3	12	1	0	1.000	1.000	1.000
235	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), HK1(1), HK2(4), HK3(1), LDHA(1), PDHA2(2), PFKM(1), PGM1(4), PGM3(1)	3563180	48	15	41	89	10	21	2	11	4	0	1.000	1.000	1.000
236	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(4), CAMK1G(1), INSR(2), MAPK7(1), MEF2B(3), MEF2C(1), NFATC1(6), NFATC2(2), PIK3CA(2), PPP3CA(1), PPP3CC(1)	2582756	24	15	21	54	7	6	0	8	3	0	1.000	1.000	1.000
237	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), ALDOC(1), DERA(1), FBP2(2), G6PD(1), H6PD(3), PFKM(1), PGD(1), PGM1(4), PGM3(1), PRPS1L1(2), TKT(1), TKTL2(2)	1789884	21	15	18	51	6	10	1	4	0	0	1.000	1.000	1.000
238	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	45	ACAA1(3), ACADL(3), ACADM(1), ACADS(1), ACADSB(2), ACADVL(1), ACAT1(2), ACAT2(1), ACOX1(7), ACOX3(1), ACSL3(2), ACSL5(2), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CPT1B(4), CPT1C(1), CPT2(5), CYP4A22(19), ECHS1(1), EHHADH(3), HADHB(1), HSD17B4(4)	3447363	85	15	63	62	16	30	7	26	6	0	1.000	1.000	1.000
239	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	42	AGXT(1), AGXT2(4), ALAS2(1), AMT(1), AOC2(2), AOC3(4), BHMT(1), CBS(2), CHKA(1), CTH(2), DAO(2), DMGDH(4), GAMT(1), GARS(1), HSD3B7(2), PEMT(4), PIPOX(1), SARDH(2), SARS(1), SHMT1(3), SHMT2(1)	3054937	41	15	35	68	17	15	1	8	0	0	1.000	1.000	1.000
240	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	43	ACAA1(3), ACADM(1), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOX1(4), BCAT2(3), BCKDHA(1), BCKDHB(1), DBT(1), ECHS1(1), EHHADH(3), HADHB(1), HIBCH(2), HMGCS2(1), HSD17B4(4), MCCC1(6), MCCC2(1), MCEE(5), MUT(5), OXCT1(2), OXCT2(2), PCCA(1), PCCB(1)	3164456	67	15	57	51	17	21	3	19	7	0	1.000	1.000	1.000
241	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	33	ALDH4A1(2), ASS1(1), CKM(1), CPS1(5), DAO(2), EPRS(2), GAMT(1), GOT2(4), LAP3(1), NOS1(3), OTC(4), P4HA3(2), PARS2(2), PRODH(4), RARS(2), RARS2(5)	2693606	41	15	32	53	9	16	2	12	2	0	1.000	1.000	1.000
242	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), DDC(3), EPX(3), ESCO1(1), GOT2(4), LPO(2), PNPLA3(5), TAT(2), TPO(10)	2500214	43	15	37	45	14	13	2	13	1	0	1.000	1.000	1.000
243	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACAT1(2), ACAT2(1), AFMID(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), AOX1(4), CYP1A1(2), CYP1A2(2), CYP1B1(2), DDC(3), ECHS1(1), EHHADH(3), HAAO(1), HEMK1(1), HSD17B4(4), INMT(9), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL2B(3), OGDH(2), OGDHL(3), PRMT2(1), PRMT6(2), PRMT8(1), TDO2(1), WARS2(1)	4422017	74	15	65	76	19	29	3	20	3	0	1.000	1.000	1.000
244	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(2), CTH(2), GGT1(6), HEMK1(1), LCMT1(1), LCMT2(1), MAT2B(1), METTL2B(3), PAPSS1(5), PAPSS2(1), PRMT2(1), PRMT6(2), PRMT8(1), SCLY(3)	1834106	30	15	21	25	7	12	0	8	3	0	0.994	1.000	1.000
245	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	27	AMDHD2(1), CHIA(12), CTBS(4), CYB5R1(1), CYB5R3(1), GFPT1(1), GFPT2(2), HEXB(5), HK1(1), HK2(4), HK3(1), MTMR1(3), MTMR2(4), NPL(1), PGM3(1), PHPT1(1), UAP1(1)	1998017	44	15	34	62	8	22	0	11	3	0	1.000	1.000	1.000
246	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	44	AACS(1), AADAC(2), ACADS(1), ACAT1(2), ACAT2(1), ACSM1(3), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(3), ALDH7A1(1), ALDH9A1(3), BDH1(1), BDH2(2), DDHD1(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), HMGCS2(1), HSD17B4(4), HSD3B7(2), L2HGDH(1), OXCT1(2), OXCT2(2), PDHA2(2), PLA1A(2)	2978465	54	15	48	62	8	23	3	14	6	0	1.000	1.000	1.000
247	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	56	A4GALT(3), B3GALT5(1), B3GNT1(1), B3GNT3(1), B3GNT4(2), B3GNT5(2), B4GALNT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT2(1), FUT3(6), FUT4(1), FUT5(6), GBGT1(4), PIGB(4), PIGC(3), PIGF(1), PIGG(7), PIGK(1), PIGL(1), PIGM(2), PIGN(3), PIGP(2), PIGQ(4), PIGS(1), PIGZ(3), ST3GAL6(1), ST6GALNAC3(1)	3425036	70	15	55	97	13	29	3	21	4	0	1.000	1.000	1.000
248	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(2), ARSB(5), FUCA1(2), FUCA2(8), GALNS(2), GBA(2), GLB1(1), GUSB(1), HEXB(5), HGSNAT(1), HPSE(2), HPSE2(6), IDS(1), IDUA(5), LCT(3), MAN2B2(10), MANBA(7), NAGLU(3), NEU2(3)	2419323	69	15	45	57	22	24	5	16	2	0	1.000	1.000	1.000
249	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	29	ADCY3(2), CAMK2G(1), CLCA1(2), CLCA2(10), CLCA4(6), CNGA4(3), CNGB1(4), PDE1C(5), PRKACA(1), PRKACG(2), PRKG1(3), PRKG2(1), PRKX(1)	2245279	41	15	33	73	5	20	1	11	4	0	1.000	1.000	1.000
250	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(2), CASP1(1), CASP7(3), CASP8(3), INSR(2), ITCH(1), MAGI1(3), MAGI2(4), RERE(2), WWP2(1)	1661069	22	15	20	56	1	7	0	11	3	0	1.000	1.000	1.000
251	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	40	ADCY3(2), ADCY9(4), AK1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), GNAS(1), PDIA4(2), PLCG1(3), PLCG2(5), SEC61A1(1), SEC61A2(1), TRIM23(1)	2671635	33	15	29	54	10	12	4	3	4	0	1.000	1.000	1.000
252	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(3), GRB2(1), IL3(3), IL3RA(4), JAK2(2), MAP2K1(2), PTPN6(4), RAF1(4), SOS1(1)	1314470	24	15	19	18	3	9	1	9	2	0	0.987	1.000	1.000
253	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1), F10(1), F11(1), F12(1), F2(1), F2R(1), F5(18), F8(3), F9(1), FGA(2), FGB(1), FGG(1), KLKB1(4), PROC(2), PROS1(1), SERPINC1(1), SERPING1(1)	3290647	72	15	54	84	18	31	1	19	3	0	1.000	1.000	1.000
254	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(3), ABCC2(4), ABCG2(3), BCHE(3), CYP3A4(1), CYP3A5(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3)	1577076	41	15	29	37	7	14	1	15	4	0	1.000	1.000	1.000
255	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(4), DPM2(1), ELK1(1), GRB2(1), KLK2(1), MAP2K1(2), MAPK8(1), NGFR(2), PIK3CA(2), PLCG1(3), RAF1(4), SOS1(1)	1403096	23	15	22	19	2	10	5	2	4	0	0.989	1.000	1.000
256	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	17	HLA-A(93), MAP2K1(2), PIK3CA(2), PTK2B(4), PTPN6(4), RAC1(1), VAV1(3)	1308615	109	15	75	81	12	35	4	45	12	1	1.000	1.000	1.000
257	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(3), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), ATP7A(1), ATP7B(1), COX10(3), COX7B(1), NDUFS1(1), NDUFS2(3), PPA2(4), SDHA(6), SHMT1(3), UQCRC1(1), UQCRH(2)	2776267	40	15	32	64	11	11	1	16	1	0	1.000	1.000	1.000
258	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(4), ELK1(1), GRB2(1), JAK1(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1)	2452743	32	15	29	43	3	18	5	2	4	0	1.000	1.000	1.000
259	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(7), PML(2), RB1(1), SIRT1(2), SP100(5), TNF(3), TNFRSF1B(3)	1338156	23	15	20	21	3	6	2	6	6	0	0.999	1.000	1.000
260	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), GRB2(1), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), PLCG1(3), PTK2B(4), RAC1(1), RAF1(4), SOS1(1)	2100377	31	15	27	48	6	11	6	2	6	0	1.000	1.000	1.000
261	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT2(1), CISH(1), GRB2(1), IARS(2), IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), JAK3(2), PIK3CA(2), SOS1(1), SOS2(1), STAT6(4), TYK2(3)	2690010	38	15	30	41	6	14	6	11	1	0	1.000	1.000	1.000
262	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	ATF1(1), EEF2K(3), ELK1(1), IL1R1(1), MAP2K3(4), MAP2K4(1), MAP3K10(1), MAP3K4(1), MAP3K5(1), MAPK11(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(1), MKNK2(3), NFKB1(3), TRAF6(1)	2532189	26	15	25	34	8	5	2	4	7	0	1.000	1.000	1.000
263	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT2(1), BTK(2), CDKN2A(1), GRB2(1), IARS(2), IGFBP1(2), PIK3CA(2), PTEN(2), RPS6KA1(2), RPS6KA2(1), SFN(2), SOS1(1), SOS2(1), TEC(2), YWHAE(1)	2627883	23	15	19	45	1	9	2	5	6	0	1.000	1.000	1.000
264	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BIRC2(1), CASP8(3), MAP2K4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), RALBP1(1), TNF(3), TNFRSF1B(3)	1932946	22	15	20	26	5	4	1	7	5	0	1.000	1.000	1.000
265	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2G(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), NFAT5(1), PDE6A(1), PDE6C(1), PDE6H(1), SLC6A13(2), TF(2)	2666040	29	15	26	102	9	9	0	6	5	0	1.000	1.000	1.000
266	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	35	ACAA1(3), ACADL(3), ACADM(1), ACADS(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOX1(4), BCKDHA(1), BCKDHB(1), ECHS1(1), EHHADH(3), HADHB(1), MCCC1(6), MCCC2(1), MCEE(5), MUT(5), OXCT1(2), PCCA(1), PCCB(1)	2607118	59	15	50	46	16	19	1	16	7	0	1.000	1.000	1.000
267	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(1), EGR2(1), MAP3K1(7), MYC(7), NFATC1(6), NFATC2(2), NFKB1(3), NFKBIA(3), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKACG(2), VIPR2(1)	2047935	38	15	32	48	6	11	3	13	5	0	1.000	1.000	1.000
268	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(1), IKBKB(2), MAP3K1(7), MAP3K5(1), MAP4K5(3), MAPK8(1), NFKB1(3), NFKBIA(3), TNFSF9(1)	1462264	22	14	20	22	4	7	1	5	5	0	1.000	1.000	1.000
269	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(4), BMP10(3), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMPR1A(3), CHRD(4), DVL1(1), FZD1(1), GATA4(2), MEF2C(1), NKX2-5(1), NPPA(1), TGFB2(1), TGFBR3(2)	2695065	31	14	27	53	9	10	3	9	0	0	1.000	1.000	1.000
270	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(3), ALDH9A1(3), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), L2HGDH(1), OXCT1(2), PDHA2(2)	1892140	34	14	31	41	6	14	2	9	3	0	1.000	1.000	1.000
271	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3D(1), CD3G(2), CD80(2), CD86(1), CTLA4(1), GRB2(1), HLA-DRA(2), HLA-DRB1(46), PIK3CA(2)	923199	58	14	44	30	5	25	1	23	4	0	0.965	1.000	1.000
272	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BCL2(1), BIRC2(1), CASP10(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), LMNA(3), NFKB1(3), NFKBIA(3), SPTAN1(1), TNFRSF10A(7), TNFRSF10B(4)	2478464	37	14	27	48	6	15	1	9	6	0	1.000	1.000	1.000
273	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(5), CDT1(2), GMNN(1), MCM10(7), MCM3(2), MCM4(2), MCM7(2), NACA(7), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), PRIM1(1), RFC4(2), RFC5(1), RPA4(2), UBB(1)	3641868	44	14	31	84	8	20	1	13	2	0	1.000	1.000	1.000
274	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15(2), ALOX15B(6), GGT1(6), LTA4H(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5)	1168123	29	14	23	35	7	5	3	11	3	0	1.000	1.000	1.000
275	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(3), ATM(8), ATR(6), CCNA1(1), CCND1(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), E2F1(2), RB1(1), SKP2(1), TGFB2(1)	2141217	31	14	26	30	9	11	1	6	4	0	1.000	1.000	1.000
276	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(2), ALDH5A1(3), CAD(1), CPS1(5), EPRS(2), GAD1(2), GAD2(1), GFPT1(1), GLS(1), GLS2(2), GMPS(1), GOT2(4), GPT(1), NADSYN1(1), QARS(1)	2439238	28	14	21	47	5	7	2	11	3	0	1.000	1.000	1.000
277	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(4), G6PD(1), GGT1(6), GPX5(1), GSTA3(2), GSTA4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), IDH1(1), PGD(1)	1302021	23	14	17	28	5	9	2	5	1	1	1.000	1.000	1.000
278	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	36	ACAA1(3), ACAD8(1), ADH4(4), ADH7(2), ADHFE1(1), AKR1C4(4), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BAAT(4), CEL(4), CYP27A1(1), HADHB(1), HSD3B7(2), LIPA(3), SLC27A5(8), SOAT1(1), SOAT2(3)	2243197	56	14	45	60	12	20	2	17	5	0	1.000	1.000	1.000
279	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(2), ALDH5A1(3), CAD(1), CPS1(5), EPRS(2), GAD1(2), GAD2(1), GFPT1(1), GFPT2(2), GLS(1), GLS2(2), GMPS(1), GOT2(4), GPT(1), NADSYN1(1), QARS(1)	2892271	30	14	22	57	5	9	2	11	3	0	1.000	1.000	1.000
280	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ACADM(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DPYD(9), DPYS(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), HIBCH(2), SRM(1)	1960112	49	14	41	36	9	21	1	14	4	0	0.999	1.000	1.000
281	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), ALDOC(1), FBP2(2), GOT2(4), GPT(1), MDH2(5), ME3(2), PGK2(1), TKT(1), TKTL2(2)	1482453	20	14	17	30	4	7	1	8	0	0	1.000	1.000	1.000
282	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(5), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CYP2C19(2), CYP2C9(5), DHRS1(2), DHRS2(2), DHRSX(1), ECHS1(1), EHHADH(3), ESCO1(1), PNPLA3(5), YOD1(1)	2253090	42	14	36	37	13	15	0	13	1	0	1.000	1.000	1.000
283	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(3), CARS2(5), DARS2(1), EPRS(2), FARS2(1), FARSA(2), FARSB(1), GARS(1), IARS(2), LARS(4), NARS2(1), PARS2(2), QARS(1), RARS(2), RARS2(5), SARS(1), VARS(3), VARS2(10), WARS2(1), YARS2(2)	3934887	50	14	41	79	9	26	1	10	4	0	1.000	1.000	1.000
284	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), ELK1(1), GRB2(1), IL2RA(1), IL2RB(2), JAK1(2), JAK3(2), MAP2K1(2), MAPK8(1), RAF1(4), SOS1(1)	1768450	21	14	20	40	4	9	2	2	4	0	1.000	1.000	1.000
285	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	DLAT(1), IDH3A(1), IDH3B(1), MDH2(5), OGDH(2), PC(1), PDHA2(2), PDHX(3), SDHA(6), SDHC(1), SUCLG2(1)	2018568	24	14	19	41	8	9	2	4	1	0	1.000	1.000	1.000
286	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(4), CAPN2(4), EP300(5), HDAC2(2), NFATC1(6), NFATC2(2), PPP3CA(1), PPP3CC(1)	1783310	25	14	20	26	6	5	0	12	2	0	1.000	1.000	1.000
287	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(1), GNA13(2), GNGT1(1), MYLK(8), PLCB1(8), PPP1R12B(1)	1504290	23	14	19	19	3	4	2	5	9	0	0.993	1.000	1.000
288	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	26	CCR1(1), CCR2(3), CCR3(1), CSF2(1), IFNGR2(2), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), IL4R(15), TGFB2(1)	1404396	37	14	25	39	7	12	8	9	1	0	1.000	1.000	1.000
289	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ARHGEF1(1), F2(1), F2R(1), F2RL3(1), GNA13(2), GNGT1(1), PIK3CA(2), PLCB1(8), PPP1R12B(1), PTK2B(4)	1892787	22	14	18	35	2	5	0	4	11	0	1.000	1.000	1.000
290	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(7), EP300(5), PELP1(6)	1122315	18	14	14	20	1	5	0	8	4	0	1.000	1.000	1.000
291	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), ALDOC(1), FBP2(2), G6PD(1), H6PD(3), PFKM(1), PGD(1), PGM1(4), PGM3(1), PRPS1L1(2), TKT(1)	1479934	18	14	15	49	6	9	0	3	0	0	1.000	1.000	1.000
292	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), DDC(3), EPX(3), GOT2(4), LPO(2), TAT(2), TPO(10)	1626548	37	14	32	39	14	11	2	9	1	0	1.000	1.000	1.000
293	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(4), CREBBP(7), DVL1(1), EP300(5), FZD1(1), PITX2(1), TRRAP(2)	2430669	21	14	20	26	5	6	1	6	3	0	1.000	1.000	1.000
294	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(7), EP300(5), LPL(1), NCOA1(2), NCOA2(1), PPARG(3)	1337157	19	14	17	12	1	7	0	7	4	0	0.984	1.000	1.000
295	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(1), GLI2(6), GLI3(3), PRKACG(2), SHH(1), SMO(2)	1223834	18	14	15	29	6	3	1	6	2	0	1.000	1.000	1.000
296	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), F2R(1), F2RL3(1), GNGT1(1), ITGA1(3), MAP2K1(2), PLA2G4A(1), PLCB1(8), PTGS1(3), PTK2(2), RAF1(4), TBXAS1(5)	1779098	32	14	29	45	7	9	1	9	6	0	1.000	1.000	1.000
297	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(4), EGFR(4), GRB2(1), MAP2K1(2), PTPRB(8), RAF1(4), RASA1(2), SOS1(1), SPRY3(1)	1782943	28	14	23	32	3	15	4	5	1	0	1.000	1.000	1.000
298	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(8), APOA1(1), APOA4(4), APOC2(1), CETP(5), DGAT1(1), HMGCR(1), LCAT(1), LDLR(3), LIPC(3), LPL(1), LRP1(6), SOAT1(1)	1991949	36	14	28	46	9	16	2	8	1	0	1.000	1.000	1.000
299	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(4), CDH1(1), CREBBP(7), EP300(5), MAP2K1(2), TGFB2(1)	1878924	20	14	19	15	4	6	1	6	3	0	0.993	1.000	1.000
300	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	IFNGR2(2), IKBKB(2), JAK2(2), NFKB1(3), NFKBIA(3), RB1(1), TNF(3), TNFRSF1B(3), USH1C(1)	1349903	20	14	17	27	2	5	0	7	6	0	1.000	1.000	1.000
301	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	16	CHUK(1), IKBKAP(11), IKBKB(2), MAP3K1(7), NFKB1(3), NFKBIA(3), TANK(2), TNFRSF1B(3), TRAF1(2), TRAF3(4)	1559001	38	14	28	28	9	15	0	8	6	0	0.997	1.000	1.000
302	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(3), ACTN2(1), ITGA1(3), ITGB3(3), PTK2(2), RAC1(1), SPTAN1(1), TLN1(6)	2124621	20	14	15	31	5	4	2	6	3	0	1.000	1.000	1.000
303	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(4), CHUK(1), GH1(2), GHR(2), NFKB1(3), NFKBIA(3), PDPK1(1), PIK3CA(2), PPP2CA(1)	1081965	19	13	16	20	1	8	1	3	6	0	0.999	1.000	1.000
304	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(5), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH4A1(2), ALDH9A1(3), AOC2(2), AOC3(4), CKM(1), CPS1(5), DAO(2), GAMT(1), GOT2(4), NOS1(3), OTC(4), P4HA3(2), RARS(2)	3328985	51	13	40	68	16	16	0	17	2	0	1.000	1.000	1.000
305	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA1(3), ADH4(4), ADH7(2), ADHFE1(1), AKR1C4(4), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), BAAT(4), CEL(4), CYP27A1(1), HADHB(1), SOAT2(3)	1645381	41	13	33	47	8	16	1	11	5	0	1.000	1.000	1.000
306	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CD80(2), CR2(7), FCGR2B(1), HLA-DRA(2), HLA-DRB1(46), ICAM1(6), ITGAL(1), PTPRC(1)	867852	66	13	46	37	6	29	1	28	2	0	0.977	1.000	1.000
307	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), ALDOC(1), FBP2(2), GOT2(4), GPT(1), MDH2(5), ME2(2), ME3(2), TKT(1)	1330472	19	13	16	29	4	7	1	7	0	0	1.000	1.000	1.000
308	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(7), EP300(5), NCOA3(3), PRKACG(2)	1523791	17	13	15	30	1	5	0	7	4	0	1.000	1.000	1.000
309	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(11), IKBKB(2), MAP3K1(7), NFKB1(3), NFKBIA(3), TRAF3(4), TRAF6(1)	1281025	32	13	24	23	7	14	0	6	5	0	0.996	1.000	1.000
310	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCND1(1), CCND2(2), CCND3(3), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), E2F1(2), RB1(1)	1174635	17	13	16	21	4	4	1	4	4	0	1.000	1.000	1.000
311	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ASAH1(4), GNGT1(1), ITGB3(3), PIK3CA(2), PLCB1(8), PTK2(2), RAC1(1), SMPD2(7), SPHK1(1)	1985882	29	13	20	46	5	7	2	8	7	0	1.000	1.000	1.000
312	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(4), MAP2K1(2), MAP3K1(7), NCOR2(9), THRA(1), THRB(2)	1301855	29	13	25	26	8	14	1	4	2	0	0.999	1.000	1.000
313	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(1), CSF2(1), HLA-DRA(2), HLA-DRB1(46), IL3(3)	208541	54	13	38	20	6	23	1	22	2	0	0.447	1.000	1.000
314	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	24	ALDOB(1), ALDOC(1), FBP2(2), FPGT(1), GMPPB(2), HK1(1), HK2(4), HK3(1), PFKM(1), PMM2(1), SORD(5)	1724003	20	13	16	48	4	6	0	9	1	0	1.000	1.000	1.000
315	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT2(1), FBP2(2), GAA(1), GALK2(1), GALT(2), GANAB(3), GLB1(1), HK1(1), HK2(4), HK3(1), LALBA(1), LCT(3), MGAM(12), PFKM(1), PGM1(4), PGM3(1)	2384083	39	13	33	69	6	17	1	9	6	0	1.000	1.000	1.000
316	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), JUNB(1), MAP2K3(4), NFATC1(6), NFATC2(2), PRKACG(2)	921502	17	13	14	25	5	3	1	7	1	0	1.000	1.000	1.000
317	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ELK1(1), GNAS(1), GNGT1(1), MAP2K1(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKACG(2), RAF1(4)	2587317	26	13	22	49	6	8	3	8	1	0	1.000	1.000	1.000
318	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(2), CLYBL(4), IDH1(1), IDH3A(1), IDH3B(1), MDH2(5), OGDH(2), OGDHL(3), PC(1), PCK1(3), PCK2(1), SDHA(6), SDHC(1), SUCLG2(1)	2094585	32	13	25	49	8	12	1	9	2	0	1.000	1.000	1.000
319	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(5), ALDH18A1(2), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), ASS1(1), CPS1(5), OTC(4), SRM(1)	2171687	38	13	29	39	9	14	0	13	2	0	1.000	1.000	1.000
320	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	6	CYP1A2(2), CYP2A13(5), CYP2A7(8), NAT1(1), NAT2(7), XDH(6)	510834	29	13	20	23	5	15	2	5	2	0	0.981	1.000	1.000
321	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(4), G6PD(1), GGT1(6), GPX5(1), GSTA3(2), GSTA4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), IDH1(1), OPLAH(8)	1626442	30	13	21	31	10	8	3	7	1	1	1.000	1.000	1.000
322	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(5), PGAP1(2), PIGB(4), PIGC(3), PIGF(1), PIGG(7), PIGK(1), PIGL(1), PIGM(2), PIGN(3), PIGP(2), PIGQ(4), PIGS(1), PIGW(2), PIGZ(3)	1820298	41	13	32	61	4	22	2	12	1	0	1.000	1.000	1.000
323	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	ALOX15(2), CYP1A2(2), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2J2(1), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), HSD3B7(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1)	1744179	42	13	35	37	13	10	1	12	6	0	1.000	1.000	1.000
324	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(2), ACACB(12), ACADM(1), ACAT1(2), ACAT2(1), ACSS1(2), ACSS2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), ECHS1(1), EHHADH(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(7), MCEE(5), MUT(5), PCCA(1), PCCB(1), SUCLG2(1)	2888515	64	13	50	62	24	24	1	12	3	0	1.000	1.000	1.000
325	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(4), BST1(4), ENPP1(3), ENPP3(3), NADSYN1(1), NMNAT1(1), NMNAT2(1), NNT(2), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), NUDT12(2), QPRT(1)	1517162	29	13	22	27	7	15	2	3	2	0	0.999	1.000	1.000
326	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(4), ELK1(1), GRB2(1), IRS1(2), MAP2K1(2), MAPK8(1), PIK3CA(2), RAF1(4), RASA1(2), SOS1(1)	1814064	20	13	19	22	2	11	2	1	4	0	1.000	1.000	1.000
327	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(1), HLA-DRA(2), HLA-DRB1(46), IL5RA(2), IL6(2)	380519	54	13	40	27	7	22	1	22	2	0	0.860	1.000	1.000
328	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(4), ELK1(1), GRB2(1), INSR(2), IRS1(2), MAP2K1(2), MAPK8(1), PIK3CA(2), RAF1(4), RASA1(2), SLC2A4(1), SOS1(1)	1871350	23	13	22	34	3	13	2	1	4	0	1.000	1.000	1.000
329	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(8), AASDHPPT(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DOT1L(2), ECHS1(1), EHHADH(3), EHMT1(1), EHMT2(2), PLOD1(2), PLOD2(2), SHMT1(3), SHMT2(1)	2719521	46	13	39	58	11	18	0	14	3	0	1.000	1.000	1.000
330	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), ENPP1(3), ENPP3(3), NADSYN1(1), NMNAT1(1), NMNAT2(1), NNT(2), NT5C(1), NT5E(2), NT5M(1), QPRT(1)	1071560	20	13	15	11	3	12	1	3	1	0	0.786	1.000	1.000
331	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(2), PLCB1(8), PLCG1(3), VAV1(3)	939047	16	13	13	16	1	2	2	4	7	0	0.999	1.000	1.000
332	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	25	ALAD(2), BLVRA(1), CP(1), CPOX(1), EPRS(2), GUSB(1), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2), UROS(1)	1917940	40	13	28	44	6	12	1	21	0	0	1.000	1.000	1.000
333	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(2), ACADL(3), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(1), EHHADH(3), LDHA(1), MCEE(5), MUT(5), PCCA(1), PCCB(1), SUCLG2(1)	2418125	43	13	36	41	12	17	0	12	2	0	1.000	1.000	1.000
334	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(7), DFFA(1), GZMB(5), HMGB2(1), PRF1(2)	788678	16	13	14	12	4	2	2	5	3	0	0.982	1.000	1.000
335	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(3), DUSP4(2), EEF2K(3), GRB2(1), MAP2K1(2), MKNK1(1), MKNK2(3), MOS(2), NFKB1(3), RPS6KA1(2), RPS6KA2(1), SOS1(1), SOS2(1), TRAF3(4)	2214013	30	13	27	50	6	11	2	6	5	0	1.000	1.000	1.000
336	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(2), HLA-DRA(2), HLA-DRB1(46), PTPRC(1), ZAP70(1)	665273	53	13	39	28	6	21	1	22	3	0	0.932	1.000	1.000
337	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(4), GRB2(1), JAK2(2), MAP2K1(2), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1)	2079522	22	13	20	27	1	12	3	3	3	0	1.000	1.000	1.000
338	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1), SLC23A1(1), SLC2A3(1)	1889149	34	13	26	50	8	10	1	10	5	0	1.000	1.000	1.000
339	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(5), C5(6), C6(3), C7(7), C8A(9), C9(2)	926345	32	12	25	26	6	11	0	14	1	0	0.999	1.000	1.000
340	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(3), CDKN2A(1), E2F1(2), MYC(7), PIK3CA(2), POLR1A(3), POLR1B(2), RAC1(1), RB1(1)	1408115	22	12	22	36	6	6	2	6	2	0	1.000	1.000	1.000
341	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BCL2(1), CASP8(3), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFKB1(3), RAF1(4)	1497609	22	12	20	29	4	9	3	2	4	0	1.000	1.000	1.000
342	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	CLDN5(2), CLOCK(2), EIF4G2(1), ETV6(1), GFRA1(1), GSTP1(1), HERPUD1(2), MYF6(1), NCKAP1(2), PER1(4), PER2(4), PIGF(1), UCP3(1), ZFR(2)	2635257	25	12	21	47	5	10	0	4	5	1	1.000	1.000	1.000
343	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	FHL5(5), FSHR(5), GNAS(1), XPO1(3)	704071	14	12	10	11	5	4	2	3	0	0	0.980	1.000	1.000
344	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	19	IFNA1(2), IL12B(2), IL16(4), IL1A(2), IL3(3), IL6(2), IL9(1), TNF(3)	687217	19	12	15	19	7	8	0	3	1	0	0.997	1.000	1.000
345	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	20	ANPEP(4), CD2(1), CD5(3), CSF2(1), IFNA1(2), IL12B(2), IL3(3), ITGAX(6), TLR2(2), TLR4(2), TLR7(1)	1295386	27	12	19	16	8	11	0	7	1	0	0.856	1.000	1.000
346	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), DDX20(9), E2F1(2), ETS1(1), ETS2(2), HDAC2(2), NCOR2(9), RBL2(3)	2019780	30	12	22	43	7	12	2	7	2	0	1.000	1.000	1.000
347	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(2), MAP2K3(4), MAP3K1(7), NFKB1(3), PIK3CA(2), RB1(1), SP1(1)	1441506	20	12	18	28	4	7	2	2	5	0	1.000	1.000	1.000
348	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	B4GALT2(1), G6PC2(6), GAA(1), GALK2(1), GALT(2), GANC(5), GLB1(1), HK1(1), HK2(4), HK3(1), HSD3B7(2), LALBA(1), LCT(3), MGAM(12), PFKM(1), PGM1(4), PGM3(1)	2785763	47	12	37	78	6	18	3	14	6	0	1.000	1.000	1.000
349	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	DHCR7(1), FDFT1(2), GGCX(2), GGPS1(1), HMGCR(1), HSD17B7(4), IDI2(2), LSS(3), MVK(2), NSDHL(1), SQLE(1), TM7SF2(3)	1401552	23	12	19	46	7	8	2	3	3	0	1.000	1.000	1.000
350	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DDC(3), FTCD(1), HDC(4), HEMK1(1), HNMT(1), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1)	2933698	51	12	42	56	16	19	1	10	5	0	1.000	1.000	1.000
351	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	21	ACP2(3), ACP5(1), ACP6(1), ALPL(2), ALPP(13), ALPPL2(5), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), DHRS1(2), DHRS2(2), DHRSX(1), PON1(6), PON2(3)	1263350	50	12	37	44	9	13	1	20	7	0	1.000	1.000	1.000
352	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA1(2), FUCA2(8), GLB1(1), HEXB(5), LCT(3), MAN2B2(10), MANBA(7), NEU2(3)	1333347	41	12	24	27	9	21	3	7	1	0	0.971	1.000	1.000
353	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(1), EXTL1(2), EXTL3(1), HS3ST1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(3), HS6ST2(1), HS6ST3(2), NDST1(1), NDST3(1)	1549052	16	12	15	44	2	4	1	7	2	0	1.000	1.000	1.000
354	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	34	ARSA(4), ARSE(1), ASAH1(4), CERK(2), DEGS1(1), DEGS2(4), ENPP7(4), GAL3ST1(4), GALC(3), GBA(2), GLB1(1), LCT(3), NEU2(3), PPAP2B(1), SGPP1(1), SMPD2(7), SMPD4(2), SPHK1(1), SPHK2(1), UGT8(1)	2493982	50	12	37	56	8	22	3	13	4	0	1.000	1.000	1.000
355	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(1), ACOT11(5), ACYP1(1), DHRS1(2), DHRS2(2), DHRSX(1), ECHS1(1), EHHADH(3), ESCO1(1), PNPLA3(5), YOD1(1)	1885055	25	12	21	27	5	10	0	10	0	0	1.000	1.000	1.000
356	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	14	BPNT1(1), CHST11(1), CHST12(4), CHST13(2), PAPSS1(5), PAPSS2(1), SULT1A1(3), SULT1A2(3), SULT2B1(3), SUOX(1)	850793	24	12	20	17	7	5	0	10	2	0	0.993	1.000	1.000
357	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2A1L(2), GTF2E1(1), GTF2F1(3), GTF2I(2), GTF2IRD1(1), STON1(3), TAF1(3), TAF1L(2), TAF2(2), TAF4(1), TAF4B(2), TAF5L(2), TAF6(1), TAF6L(1), TAF7L(5)	2665793	32	12	31	51	4	10	2	11	5	0	1.000	1.000	1.000
358	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLG(2), POLG2(1), POLH(2), POLL(1), POLM(1), POLQ(15), PRIM1(1), REV3L(4), RFC5(1)	2858816	39	12	33	43	7	13	2	15	2	0	1.000	1.000	1.000
359	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(4), EIF2S2(1), EIF2S3(2), INPPL1(1), PDPK1(1), PIK3CA(2), PPP2CA(1), PTEN(2)	1483847	14	12	13	24	2	5	0	5	2	0	1.000	1.000	1.000
360	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CD3G(2), ETV5(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), JAK2(2), MAPK8(1), TYK2(3)	1381689	23	12	19	25	5	5	2	8	3	0	1.000	1.000	1.000
361	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	IL10RA(4), IL22RA1(2), IL22RA2(2), JAK1(2), JAK2(2), JAK3(2), SOCS3(1), STAT1(1), TYK2(3)	1284880	19	12	18	29	5	3	3	7	1	0	1.000	1.000	1.000
362	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(1), IL4R(15), IRS1(2), JAK1(2), JAK3(2), STAT6(4)	1084453	26	12	19	26	5	9	6	4	2	0	1.000	1.000	1.000
363	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN2(4), EGF(4), EGFR(4), ITGA1(3), MYLK(8), PRKACG(2), PTK2(2), TLN1(6)	2464145	33	12	24	50	7	9	2	12	3	0	1.000	1.000	1.000
364	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(6), ATM(8), CDKN1A(4), CPB2(2), CSNK1A1(2), IGFBP3(1), MAPK8(1), NFKBIB(1)	1490935	25	12	20	21	3	13	1	6	2	0	0.994	1.000	1.000
365	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	ATM(8), BCL2(1), CCND1(1), CDKN1A(4), E2F1(2), RB1(1)	1261450	17	12	14	22	3	8	0	3	3	0	1.000	1.000	1.000
366	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	17	GUSB(1), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2)	1216630	30	12	19	33	3	8	1	18	0	0	1.000	1.000	1.000
367	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CCND1(1), CDKN1A(4), CDKN1B(1), E2F1(2), NFKB1(3), NFKBIA(3), PIK3CA(2), RAC1(1), RAF1(4), RB1(1)	1489831	22	12	20	25	4	7	0	5	6	0	1.000	1.000	1.000
368	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(1), BPNT1(1), GRB2(1), ILK(1), PIK3CA(2), PIK3CD(1), PTEN(2), PTK2B(4), RBL2(3), SOS1(1)	1478442	17	12	14	37	3	4	0	5	5	0	1.000	1.000	1.000
369	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(2), CTH(2), GGT1(6), MAT2B(1), PAPSS1(5), PAPSS2(1), SCLY(3)	916094	20	12	13	15	5	5	0	8	2	0	0.976	1.000	1.000
370	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	C9orf47(1), CNR2(4), DNMT1(2), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGFR(1), PTGIR(2)	848418	16	12	14	36	2	9	1	4	0	0	1.000	1.000	1.000
371	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(4), BRAF(3), RAF1(4), SNX13(1), TERF2IP(1)	848206	17	12	13	11	0	11	1	4	1	0	0.915	1.000	1.000
372	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(8), MAP2(2), PPP1CA(1), PPP2CA(1), PRKACG(2)	1224276	14	11	10	21	0	7	0	7	0	0	1.000	1.000	1.000
373	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD80(2), HLA-DRA(2), HLA-DRB1(46)	284773	50	11	36	27	5	21	1	21	2	0	0.937	1.000	1.000
374	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRA(2), HLA-DRB1(46)	169872	48	11	34	22	5	19	1	21	2	0	0.766	1.000	1.000
375	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(4), DBH(7), DDC(3), GAD1(2), GAD2(1), HDC(4), PAH(1), TH(3)	1060398	26	11	18	33	14	5	1	6	0	0	1.000	1.000	1.000
376	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2)	662195	16	11	13	25	6	5	3	1	1	0	1.000	1.000	1.000
377	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	BIRC2(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), GZMB(5), LMNA(3), PRF1(2)	1424390	28	11	22	36	7	5	3	9	4	0	1.000	1.000	1.000
378	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	IDH1(1), IDH3A(1), IDH3B(1), MDH2(5), PC(1), PCK1(3), SDHA(6), SUCLG2(1)	1430973	19	11	14	38	5	9	1	3	1	0	1.000	1.000	1.000
379	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), DRD2(1), GRM1(2), PLCB1(8), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKACG(2)	1180726	17	11	14	29	0	2	0	7	8	0	1.000	1.000	1.000
380	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(1), FLT3(1), IL11(1), IL1A(2), IL3(3), IL6(2), IL9(1), KITLG(1), TGFB2(1)	631490	13	11	11	12	5	5	0	3	0	0	0.970	1.000	1.000
381	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(1), F2R(1), F5(18), F7(3), FGA(2), FGB(1), FGG(1), PROC(2), PROS1(1), SERPINC1(1)	1207552	32	11	23	39	8	20	0	4	0	0	1.000	1.000	1.000
382	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(8), F2(1), F2R(1), FGA(2), FGB(1), FGG(1), PLAT(1), PLG(4), SERPINB2(4), SERPINE1(1)	974522	26	11	18	31	4	13	0	9	0	0	1.000	1.000	1.000
383	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(2), ACACB(12), FASN(3), MCAT(1)	1217851	18	11	15	23	11	4	1	2	0	0	1.000	1.000	1.000
384	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2)	662195	16	11	13	25	6	5	3	1	1	0	1.000	1.000	1.000
385	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(3), IARS(2), LARS(4), PDHA2(2), VARS(3), VARS2(10)	1352774	24	11	17	40	5	14	1	3	1	0	1.000	1.000	1.000
386	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS1(2), DHRS2(2), DHRSX(1), HSD3B7(2), PON1(6), PON2(3)	606368	16	11	13	20	2	5	0	9	0	0	1.000	1.000	1.000
387	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B3GNT6(1), B4GALT5(1), C1GALT1C1(1), GALNT1(1), GALNT10(1), GALNT12(1), GALNT2(2), GALNT4(5), GALNT5(1), GALNT6(1), GALNT8(8), GALNT9(1), GCNT1(4), GCNT4(2), ST6GALNAC1(3), WBSCR17(1)	2305853	34	11	26	43	4	17	1	12	0	0	1.000	1.000	1.000
388	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(2), GLB1(1), GUSB(1), HEXB(5), HGSNAT(1), HPSE(2), HPSE2(6), IDS(1), IDUA(5), LCT(3), NAGLU(3)	1543835	35	11	24	43	13	11	2	9	0	0	1.000	1.000	1.000
389	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(1), B3GNT7(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), CHST2(1), CHST4(2), CHST6(1), FUT8(4)	841467	15	11	13	15	5	3	0	6	1	0	0.998	1.000	1.000
390	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(1), CHPT1(2), ENPP2(3), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLD1(4), PLD2(13), PPAP2B(1)	1736404	32	11	22	36	8	8	4	7	5	0	1.000	1.000	1.000
391	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	20	B3GNT1(1), B3GNT3(1), B3GNT4(2), B3GNT5(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT2(1), FUT3(6), FUT4(1), FUT5(6), ST3GAL6(1)	1123499	26	11	21	22	10	5	1	9	1	0	0.997	1.000	1.000
392	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(6), AMT(1), ATIC(1), FTCD(1), GART(3), MTHFD1(4), MTHFR(4), MTR(4), SHMT1(3), SHMT2(1)	1405984	28	11	20	22	5	17	1	5	0	0	0.989	1.000	1.000
393	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(3), LPO(2), MTHFR(4), SHMT1(3), SHMT2(1), TPO(10)	846904	23	11	18	24	6	8	2	7	0	0	1.000	1.000	1.000
394	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	13	ACP2(3), ACP5(1), ACP6(1), ENPP1(3), ENPP3(3), FLAD1(1), MTMR1(3), MTMR2(4), PHPT1(1)	944968	20	11	15	24	5	4	2	8	1	0	1.000	1.000	1.000
395	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(7), ACOX3(1), ELOVL6(1), FASN(3), HSD17B12(2), PECR(4), SCD(2)	1132589	23	11	17	18	7	6	0	10	0	0	0.985	1.000	1.000
396	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(3), LPO(2), SHMT1(3), SHMT2(1), TPO(10)	872150	19	11	15	19	6	6	2	5	0	0	0.999	1.000	1.000
397	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(2), FUCA1(2), FUCA2(8), GLB1(1), HEXB(5), LCT(3), MANBA(7), NEU2(3)	1185795	31	11	17	25	6	16	3	5	1	0	0.994	1.000	1.000
398	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), NOS1(3), PPP3CA(1), PPP3CC(1), PRKACG(2)	1912188	16	11	13	55	5	5	0	5	1	0	1.000	1.000	1.000
399	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(1), GALNT10(1), GALNT2(2), GALNT4(5), GALNT6(1), GALNT8(8), GALNT9(1), GCNT1(4), WBSCR17(1)	1026964	24	11	18	30	2	12	1	9	0	0	1.000	1.000	1.000
400	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), AMT(1), ATIC(1), GART(3), MTHFD1(4), MTHFR(4), MTR(4), SHMT1(3), SHMT2(1)	1303963	27	11	19	19	4	17	1	5	0	0	0.970	1.000	1.000
401	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(3), NFKBIA(3), PLCB1(8)	608492	14	11	11	14	1	1	0	3	9	0	0.999	1.000	1.000
402	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(8), ATR(6), CDC25C(4), CHEK2(2)	1080189	20	11	15	10	6	9	0	4	0	1	0.896	1.000	1.000
403	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2A1(1), GTF2E1(1), GTF2F1(3), NCOA1(2), NCOA2(1), NCOA3(3), NCOR2(9), TBP(2)	1867153	22	11	21	34	6	8	1	3	4	0	1.000	1.000	1.000
404	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	GTF2E1(1), ILK(1), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3E(1), TAF6(1), TBP(2)	2586925	13	11	13	54	4	3	0	4	2	0	1.000	1.000	1.000
405	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC2(1), CASP10(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), GZMB(5), PRF1(2), SCAP(3), SREBF1(1), SREBF2(5)	1391676	30	11	22	21	9	6	3	11	1	0	0.987	1.000	1.000
406	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(1), ITPKA(1), PDE1B(1), PLCB1(8), TRH(2)	818032	13	11	10	21	0	3	0	4	6	0	1.000	1.000	1.000
407	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), TYK2(3)	764587	23	11	16	26	3	6	6	8	0	0	1.000	1.000	1.000
408	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), TYK2(3)	764587	23	11	16	26	3	6	6	8	0	0	1.000	1.000	1.000
409	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC1B(3), NCK1(2), NCKAP1(2), NTRK1(3), RAC1(1), WASF1(1), WASF3(3), WASL(1)	1125112	16	10	14	19	6	4	1	5	0	0	0.999	1.000	1.000
410	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ADSS(1), AGXT(1), AGXT2(4), CAD(1), DDO(1), GAD1(2), GAD2(1), GOT2(4), GPT(1), PC(1)	1913999	17	10	14	35	5	2	1	9	0	0	1.000	1.000	1.000
411	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(1), GFPT1(1), HEXB(5), HK1(1), HK2(4), HK3(1), PGM3(1), UAP1(1)	1258083	15	10	11	31	2	8	0	4	1	0	1.000	1.000	1.000
412	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3)	1106699	14	10	12	15	3	9	1	1	0	0	0.991	1.000	1.000
413	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	BCL2(1), CSF2RB(3), IL3(3), IL3RA(4), KITLG(1), PIK3CA(2), PRKACG(2)	1610040	16	10	10	40	2	4	0	10	0	0	1.000	1.000	1.000
414	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CDKN1A(4), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), SP1(1), SP3(2)	1502460	22	10	18	24	4	7	2	8	1	0	1.000	1.000	1.000
415	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), EGF(4), EGFR(4), GRB2(1), MET(2), SH3GLB2(2)	1409572	14	10	12	39	1	9	0	2	2	0	1.000	1.000	1.000
416	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(3), ACTN2(1), BCAR1(2), CSK(3), CTNNA2(3), PTK2(2)	1433513	14	10	12	24	4	2	1	6	1	0	1.000	1.000	1.000
417	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	CAMK2G(1), GNAS(1), GRB2(1), PIK3CA(2), PRKACG(2), RAC1(1), RPS6KA1(2), RPS6KA5(1), SOS1(1)	2173768	12	10	10	51	2	4	0	5	1	0	1.000	1.000	1.000
418	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(6), SHMT1(3), SHMT2(1)	319924	10	10	6	5	3	3	0	4	0	0	0.789	1.000	1.000
419	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	GRB2(1), MAPK7(1), MEF2B(3), MEF2C(1), NTRK1(3), PIK3CA(2), PLCG1(3), RPS6KA1(2)	1459328	16	10	13	33	2	4	2	6	2	0	1.000	1.000	1.000
420	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3)	1106699	14	10	12	15	3	9	1	1	0	0	0.991	1.000	1.000
421	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	ARSA(4), ARSB(5), ARSE(1), ASAH1(4), GAL3ST1(4), GALC(3), GBA(2), GLB1(1), LCT(3), NEU2(3), PPAP2B(1), SMPD2(7)	1643521	38	10	25	36	6	17	2	10	3	0	1.000	1.000	1.000
422	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	11	GRHPR(4), HAO1(1), HYI(1), MDH2(5), MTHFD1(4)	853135	15	10	11	20	3	6	1	5	0	0	1.000	1.000	1.000
423	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DDC(3), HDC(4), HNMT(1)	1797143	39	10	32	37	13	12	1	9	4	0	1.000	1.000	1.000
424	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS2(5), CTH(2), GOT2(4), LDHA(1), LDHAL6A(2), LDHAL6B(7), SULT1C2(2), SULT4A1(1)	877846	24	10	18	23	4	8	0	9	3	0	1.000	1.000	1.000
425	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(4), GAD1(2), GAD2(1), GGT1(6)	428172	13	10	9	9	4	2	0	7	0	0	0.943	1.000	1.000
426	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ADH4(4), ADH7(2), ADHFE1(1), DHRS1(2), DHRS2(2), DHRSX(1), ESCO1(1), PNPLA3(5)	1804083	19	10	14	27	1	6	1	9	2	0	1.000	1.000	1.000
427	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS1(2), DHRS2(2), DHRSX(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1)	1089110	15	10	12	18	3	9	0	2	1	0	0.998	1.000	1.000
428	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	AFMID(1), GRHPR(4), HAO1(1), HYI(1), MDH2(5), MTHFD1(4)	898705	16	10	12	22	4	6	1	5	0	0	1.000	1.000	1.000
429	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC1(3), APOBEC2(2), APOBEC3B(3), APOBEC3C(1), APOBEC3F(3), APOBEC3G(1), APOBEC4(8)	527269	24	10	18	29	2	18	0	3	1	0	1.000	1.000	1.000
430	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), CA13(1), CA3(2), CA5A(1), CA6(5), CA9(5), CPS1(5), CTH(2), GLS(1), GLS2(2)	1540055	25	10	16	29	3	7	3	9	3	0	1.000	1.000	1.000
431	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(3), GBA(2), LPO(2), TPO(10)	618695	17	10	14	15	5	3	3	5	1	0	0.996	1.000	1.000
432	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	ATG12(1), ATG3(1), ATG7(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), PIK3C3(1), PIK3R4(1), PRKAA1(1), ULK1(3), ULK2(1), ULK3(3)	1547037	28	10	26	20	5	9	1	9	4	0	0.978	1.000	1.000
433	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	10	CLOCK(2), CSNK1E(1), NPAS2(4), PER1(4), PER2(4)	1090038	15	10	13	19	4	5	0	5	1	0	1.000	1.000	1.000
434	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	BCL2(1), CASP9(4), IL1A(2), MAPKAPK2(1), TNF(3)	766358	11	10	9	25	2	5	1	2	1	0	1.000	1.000	1.000
435	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(4), IFNAR2(3), JAK1(2), STAT1(1), STAT2(3), TYK2(3)	795943	18	10	15	19	4	4	1	8	1	0	0.999	1.000	1.000
436	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(6), ITGA4(5), ITGAL(1), SELE(3), SELL(3)	892169	21	10	16	30	4	10	0	6	0	1	1.000	1.000	1.000
437	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(3), ACADM(1), ACADS(1), ACADVL(1), ACSL3(2), CPT2(5), EHHADH(3), PECR(4)	1226141	20	10	15	17	2	12	0	4	2	0	0.993	1.000	1.000
438	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(6), ITGA4(5), ITGAL(1), ITGAM(6), SELE(3), SELL(3), SELP(6)	1185802	33	10	25	39	7	17	0	8	0	1	1.000	1.000	1.000
439	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB11(2), ABCC1(3), ABCC3(5), GSTP1(1)	1054274	17	10	15	36	5	8	1	1	2	0	1.000	1.000	1.000
440	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A2(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), MKNK1(1), PDPK1(1), PIK3CA(2), PPP2CA(1), PTEN(2), TSC1(4)	2061261	17	10	17	34	3	4	1	6	3	0	1.000	1.000	1.000
441	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), DPAGT1(2), FUT8(4), MAN1B1(1), MGAT1(6), MGAT4A(2), MGAT5(1), RPN2(1), ST6GAL1(3)	1490312	25	10	21	20	6	8	3	8	0	0	0.993	1.000	1.000
442	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA3(2), CA5A(1), CA6(5), CA9(5), CPS1(5), CTH(2), GLS(1), GLS2(2)	1378211	24	10	15	28	3	6	3	9	3	0	1.000	1.000	1.000
443	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(1), CD3D(1), CD3G(2), IL12B(2), IL12RB1(8), IL12RB2(2), JAK2(2), TYK2(3)	1100637	21	10	17	24	5	4	1	9	2	0	1.000	1.000	1.000
444	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), FDXR(2), SHMT1(3)	1175640	16	10	13	16	5	9	1	1	0	0	0.989	1.000	1.000
445	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	BTK(2), EEA1(4), LYN(2), PDPK1(1), PFKM(1), PLCG1(3), RAC1(1), VAV2(3)	1820945	17	10	14	42	4	5	2	4	2	0	1.000	1.000	1.000
446	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CASP9(4), CHUK(1), ELK1(1), MAP2K1(2), NFKB1(3), PIK3CA(2), RAC1(1), RAF1(4), RALBP1(1), RALGDS(1), RHOA(2)	1448425	22	10	19	27	5	12	2	1	2	0	1.000	1.000	1.000
447	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(2), LRP8(3), RELN(9), VLDLR(2)	1008604	17	10	16	11	2	3	1	8	3	0	0.961	1.000	1.000
448	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	CISH(1), IL6(2), IL6R(2), JAK1(2), JAK2(2), JAK3(2), PTPRU(4)	1022685	15	10	13	16	5	4	0	6	0	0	0.998	1.000	1.000
449	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(4), JAK1(2), PTPRU(4), STAT1(1), STAT2(3), TYK2(3)	918688	17	10	14	20	4	4	1	7	1	0	1.000	1.000	1.000
450	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	9	EPX(3), LPO(2), TPO(10)	639444	15	10	12	15	5	3	2	5	0	0	0.998	1.000	1.000
451	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3)	1106699	14	10	12	15	3	9	1	1	0	0	0.991	1.000	1.000
452	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), DPM2(1), EGR1(1), KLK2(1), MAP2K1(2), NGFR(2), RAF1(4)	621918	12	9	12	19	2	4	2	2	2	0	1.000	1.000	1.000
453	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(2), CASP1(1), CASP10(2), CASP8(3), CASP9(4), GZMB(5), PRF1(2)	925166	19	9	15	22	5	5	3	3	3	0	1.000	1.000	1.000
454	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGF(4), EGFR(4), HGS(1), TF(2), TFRC(2)	929705	17	9	14	30	3	9	0	5	0	0	1.000	1.000	1.000
455	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	EIF4A2(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(2), MKNK1(1), PDPK1(1), PIK3CA(2), PTEN(2)	1983237	16	9	16	33	2	2	1	7	4	0	1.000	1.000	1.000
456	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHB1(3), ITGA1(3), L1CAM(1), LYN(2), SELP(6)	1140399	15	9	13	25	4	6	2	3	0	0	1.000	1.000	1.000
457	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	8	HK1(1), LCT(3), PGM1(4), PYGL(4)	962386	12	9	9	25	1	8	0	1	2	0	1.000	1.000	1.000
458	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), FARSB(1), GOT2(4), PAH(1), TAT(2), YARS2(2)	632714	13	9	11	18	2	3	1	6	1	0	1.000	1.000	1.000
459	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(3), PCYT1B(1), PRMT2(1), PRMT6(2), PRMT8(1)	1023131	13	9	10	15	2	9	0	1	1	0	0.995	1.000	1.000
460	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	CHST11(1), CHST12(4), CHST13(2), CHSY1(3), DSE(8), UST(1), XYLT1(4), XYLT2(5)	1072776	28	9	20	24	6	10	0	12	0	0	0.997	1.000	1.000
461	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(2), DHRS2(2), DHRSX(1), ESCO1(1), PNPLA3(5)	1190333	11	9	9	14	1	4	0	6	0	0	0.999	1.000	1.000
462	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	17	AADAC(2), AOC2(2), AOC3(4), DDHD1(1), ESCO1(1), LIPA(3), PLA1A(2), PNPLA3(5)	1770505	20	9	17	10	3	9	0	8	0	0	0.828	1.000	1.000
463	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPS7(1), RPL10L(2), RPL13(1), RPL14(1), RPL3(1), RPL37(1), RPL3L(2), RPL6(1)	1559020	10	9	10	31	5	3	1	0	1	0	1.000	1.000	1.000
464	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD3D(1), CD3G(2), CD58(1), IL3(3), IL6(2), KITLG(1)	460709	11	9	9	17	1	5	0	3	2	0	1.000	1.000	1.000
465	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(2), LEPR(10), PRKAA1(1)	1041897	13	9	7	14	1	3	6	3	0	0	0.996	1.000	1.000
466	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(1), EHHADH(3)	896625	18	9	17	19	4	8	0	5	1	0	0.999	1.000	1.000
467	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	BCL2(1), BIRC2(1), CASP7(3), CASP8(3), CASP9(4), DFFA(1), ENDOG(2)	991943	15	9	12	19	2	5	1	6	1	0	1.000	1.000	1.000
468	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), BIN1(1), EPS15(3), PPP3CA(1), PPP3CC(1), SYNJ1(2), SYNJ2(3)	1686103	13	9	10	32	1	7	0	3	2	0	1.000	1.000	1.000
469	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO3(2), FARS2(1), GOT2(4), PAH(1), TAT(2)	595778	11	9	9	14	2	4	0	5	0	0	0.999	1.000	1.000
470	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA2(1), ANXA4(2), EDNRA(1), HPGD(1), PLA2G4A(1), PTGFR(1), PTGIR(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5)	1586711	19	9	17	34	6	3	0	10	0	0	1.000	1.000	1.000
471	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(4), BTRC(1), DVL1(1), FZD1(1), NOTCH1(2), PSEN1(1)	1638098	11	9	11	29	3	3	1	3	1	0	1.000	1.000	1.000
472	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(2), CDKN1B(1), GRB2(1), ILK(1), PDPK1(1), PIK3CA(2), PTEN(2), PTK2(2), SOS1(1)	1450523	13	9	13	36	3	3	0	4	3	0	1.000	1.000	1.000
473	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(8), CDC25C(4), MYT1(1), RB1(1)	1234865	14	9	11	19	3	7	0	3	1	0	1.000	1.000	1.000
474	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	13	ACE(2), CD44(3), CSF1(2), IL6R(2), SELL(3), TGFB2(1), TNF(3), TNFRSF1B(3)	893988	19	9	15	25	2	8	2	6	1	0	1.000	1.000	1.000
475	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(1), CDKN1A(4), ELK1(1), GRB2(1), MAP2K1(2), NGFR(2), NTRK1(3), PIK3CA(2), PIK3CD(1), SOS1(1)	1236506	18	9	17	25	5	5	2	4	2	0	1.000	1.000	1.000
476	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(4), CKM(1), GPT(1), LDHA(1), NCL(4)	663110	11	9	10	18	3	4	0	1	3	0	1.000	1.000	1.000
477	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25C(4), CSK(3), GRB2(1), PTPRA(2)	678402	10	9	9	13	3	1	1	2	3	0	0.999	1.000	1.000
478	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B1(2), HSD17B4(4), HSD17B7(4), HSD3B1(2), HSD3B2(2)	589135	15	9	12	17	3	9	2	1	0	0	0.996	1.000	1.000
479	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), CD3G(2), ICAM1(6), ITGAL(1), PTPRC(1)	767381	12	9	9	20	1	4	0	6	1	0	1.000	1.000	1.000
480	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), CD3G(2), ICAM1(6), ITGAL(1), PTPRC(1)	809519	12	9	9	18	1	4	0	6	1	0	1.000	1.000	1.000
481	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	DPM2(1), GRB2(1), KLK2(1), NTRK1(3), PIK3CA(2), PLCG1(3), SOS1(1)	1141683	12	9	11	22	2	4	2	3	1	0	1.000	1.000	1.000
482	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3)	588587	14	8	13	16	4	5	0	4	1	0	0.999	1.000	1.000
483	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(4), AGTR1(2), AGTR2(3), KNG1(6)	741110	17	8	14	17	4	3	0	10	0	0	0.998	1.000	1.000
484	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNG(1), MUSK(5), PIK3CA(2), PTK2(2), PTK2B(4), RAPSN(1), TERT(1)	1234919	16	8	13	34	5	3	0	4	4	0	1.000	1.000	1.000
485	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	11	ARFGAP3(2), CLTB(1), COPA(1), GBF1(2), GPLD1(5)	1141674	11	8	8	17	5	4	0	1	1	0	1.000	1.000	1.000
486	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3)	588587	14	8	13	16	4	5	0	4	1	0	0.999	1.000	1.000
487	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	13	DHCR7(1), FDFT1(2), HMGCR(1), LSS(3), MVK(2), NQO2(3), SQLE(1)	782698	13	8	12	29	3	4	3	1	2	0	1.000	1.000	1.000
488	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1G(1), CAMK2G(1), CAMK4(1), CAMKK1(1), CAMKK2(5)	875442	9	8	7	26	2	2	0	4	1	0	1.000	1.000	1.000
489	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(8), CDC25C(4), MYT1(1)	1014844	13	8	10	14	3	7	0	3	0	0	0.995	1.000	1.000
490	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15)	1233070	24	8	20	24	4	10	2	7	1	0	0.999	1.000	1.000
491	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(3), DFFA(1), ENDOG(2), GZMB(5), HMGB2(1), TOP2A(3), TOP2B(2)	775933	17	8	13	17	1	3	2	10	1	0	1.000	1.000	1.000
492	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(4), EPOR(1), JAK2(2), NFKB1(3), NFKBIA(3)	967345	14	8	12	18	2	3	0	6	3	0	1.000	1.000	1.000
493	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(4), ERBB3(1), NRG1(4)	739620	13	8	10	14	2	6	0	5	0	0	0.998	1.000	1.000
494	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(4), NRG2(1), NRG3(2), PSEN1(1)	663032	9	8	8	15	2	1	0	4	2	0	1.000	1.000	1.000
495	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(3), SDHA(6), SDHC(1), UQCRC1(1)	473181	11	8	9	18	6	1	0	3	1	0	1.000	1.000	1.000
496	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	11	GABRA1(2), GABRA2(2), GABRA3(1), GABRA5(1), GABRA6(3), GPHN(2), UBQLN1(1)	851200	12	8	11	15	0	7	0	5	0	0	1.000	1.000	1.000
497	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(2), GLB1(1), GUSB(1), HEXB(5), IDS(1), IDUA(5), LCT(3), NAGLU(3)	1077485	26	8	17	38	12	9	2	3	0	0	1.000	1.000	1.000
498	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(2), GPR171(1), GPR18(1), GPR34(1), GPR39(3), GPR45(1), GPR68(1), GPR75(1)	715879	12	8	11	12	1	9	0	1	1	0	0.986	1.000	1.000
499	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3)	631532	14	8	13	28	3	5	0	5	1	0	1.000	1.000	1.000
500	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	16	BHMT(1), CBS(2), CTH(2), DNMT1(2), DNMT3B(1), MAT2B(1), MTR(4), SRM(1), TAT(2)	1486640	16	8	13	23	2	8	0	4	2	0	1.000	1.000	1.000
501	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(1), HK2(4), HK3(1), IMPA2(1), PGM1(4), PGM3(1)	877141	12	8	10	29	2	7	0	2	1	0	1.000	1.000	1.000
502	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(7), ACOX3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1)	790092	15	8	13	12	5	3	1	6	0	0	0.980	1.000	1.000
503	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	15	B4GALNT1(3), GLB1(1), HEXB(5), LCT(3), SLC33A1(1), ST6GALNAC3(1)	1139774	14	8	10	23	1	9	1	3	0	0	1.000	1.000	1.000
504	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3)	978665	21	8	17	26	3	7	1	7	3	0	1.000	1.000	1.000
505	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACSS1(2), ACSS2(1), IDH1(1), MDH2(5)	964320	11	8	7	15	3	4	1	3	0	0	0.999	1.000	1.000
506	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4)	1688473	11	8	10	41	2	4	0	5	0	0	1.000	1.000	1.000
507	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	GOSR2(2), SNAP25(1), STX16(2), STX18(1), STX2(2), TSNARE1(9), VTI1A(1)	1200905	18	8	15	25	5	4	1	5	3	0	1.000	1.000	1.000
508	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	11	BLVRA(1), IL10RA(4), IL10RB(2), IL1A(2), IL6(2), JAK1(2), STAT1(1), TNF(3)	737796	17	8	16	25	4	7	2	3	1	0	1.000	1.000	1.000
509	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CCL2(1), CSF1(2), IL6(2), LDLR(3), LPL(1)	385027	11	8	7	15	1	4	2	3	1	0	1.000	1.000	1.000
510	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	CDC25C(4), GNAS(1), GNGT1(1), MYT1(1), PRKACG(2), RPS6KA1(2)	1534712	11	8	8	37	5	0	0	6	0	0	1.000	1.000	1.000
511	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(6), ITGAL(1), ITGAM(6), SELE(3), SELL(3)	785544	22	8	16	23	3	14	0	5	0	0	0.999	1.000	1.000
512	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(4), IFNAR2(3), MAPK8(1), NFKB1(3), TNFRSF11A(3), TRAF6(1)	800175	15	8	10	10	3	4	1	5	2	0	0.950	1.000	1.000
513	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(1), MMP9(3), RECK(2), TIMP2(1), TIMP4(1)	567106	12	8	9	24	4	1	2	4	1	0	1.000	1.000	1.000
514	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	7	ACP2(3), ACP5(1), ENPP1(3), ENPP3(3), FLAD1(1)	549141	11	8	7	13	3	2	2	4	0	0	0.998	1.000	1.000
515	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDKN1A(4), NEK1(8)	565779	12	8	9	11	3	6	0	3	0	0	0.983	1.000	1.000
516	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(2), JAK2(2), JAK3(2), PIAS1(1), PTPRU(4), SOAT1(1)	1038087	13	8	12	21	4	4	1	4	0	0	1.000	1.000	1.000
517	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(1), HK2(4), HK3(1), PGM1(4), PGM3(1)	766618	11	8	9	22	2	6	0	2	1	0	1.000	1.000	1.000
518	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(2), CKM(1), CPS1(5), GAMT(1), OTC(4)	1372499	13	8	8	20	3	5	0	4	1	0	1.000	1.000	1.000
519	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), PTGS1(3), PTGS2(1)	381456	7	7	6	8	1	1	0	5	0	0	0.998	1.000	1.000
520	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(15), PRKACG(2)	742959	17	7	13	15	6	4	0	7	0	0	0.995	1.000	1.000
521	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	EPRS(2), FARS2(1), GARS(1), IARS(2), LARS(4), QARS(1), RARS(2), SARS(1), WARS2(1)	2301515	15	7	10	48	1	10	0	4	0	0	1.000	1.000	1.000
522	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	15	CCL2(1), MAPK8(1), PLCG1(3), PTK2B(4)	921581	9	7	6	21	0	1	3	2	3	0	1.000	1.000	1.000
523	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADRB2(3), CFTR(5), GNAS(1), PRKACG(2)	971932	11	7	7	30	1	5	0	3	2	0	1.000	1.000	1.000
524	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDFT1(2), HMGCR(1), LSS(3), MVK(2), NSDHL(1), SQLE(1)	977112	11	7	10	31	3	4	2	1	1	0	1.000	1.000	1.000
525	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	7	GABRA1(2), GABRA2(2), GABRA3(1), GABRA5(1), GABRA6(3)	394483	9	7	8	8	0	7	0	2	0	0	0.976	1.000	1.000
526	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	NFKB1(3), TNF(3), XDH(6)	738471	12	7	9	11	1	7	0	1	3	0	0.989	1.000	1.000
527	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	12	A4GALT(3), FUT1(1), FUT2(1), GBGT1(4), HEXB(5), NAGA(1)	682461	15	7	9	17	1	10	0	2	2	0	0.998	1.000	1.000
528	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	11	GABBR1(1), GPRC5C(2), GRM1(2), GRM2(1), GRM4(1), GRM5(1), GRM7(1)	1225425	9	7	9	36	2	3	0	4	0	0	1.000	1.000	1.000
529	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(1), ASPH(1), EP300(5), LDHA(1)	1216167	8	7	7	17	1	5	0	2	0	0	1.000	1.000	1.000
530	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	13	A4GALT(3), B3GALT5(1), FUT1(1), FUT2(1), GBGT1(4), HEXB(5), NAGA(1)	727437	16	7	10	19	1	11	0	2	2	0	0.999	1.000	1.000
531	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	ECHS1(1), EHHADH(3), HSD17B4(4), SIRT1(2), SIRT5(1)	827082	11	7	10	15	0	6	1	3	1	0	0.999	1.000	1.000
532	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(1), IRS1(2), MAP2K1(2), PIK3CA(2), RAF1(4), SOS1(1)	1373965	12	7	12	25	2	6	1	1	2	0	1.000	1.000	1.000
533	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	9	B3GNT1(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(4)	518973	9	7	8	11	4	0	0	5	0	0	0.999	1.000	1.000
534	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(1), CBS(2), CTH(2), DNMT1(2), DNMT3B(1), MAT2B(1), MTR(4)	1280246	13	7	10	20	1	7	0	3	2	0	1.000	1.000	1.000
535	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(7), GAD1(2), HDC(4), TH(3)	442339	16	7	9	16	11	0	1	4	0	0	0.993	1.000	1.000
536	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1G(1), CAMK2G(1), CAMK4(1), MEF2B(3), MEF2C(1), PPARA(1), PPP3CA(1), PPP3CC(1), SLC2A4(1)	1563287	11	7	10	42	3	3	0	3	2	0	1.000	1.000	1.000
537	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADRB2(3), GNAS(1), PLCE1(8), PRKACG(2)	1114755	14	7	12	32	2	6	1	5	0	0	1.000	1.000	1.000
538	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	16	PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), PSMB8(1), PSMB9(2)	604061	8	7	6	14	4	2	0	1	1	0	1.000	1.000	1.000
539	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25C(4), SHH(1), XPO1(3)	639780	8	7	6	11	6	0	0	2	0	0	0.998	1.000	1.000
540	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(10)	586001	10	7	6	8	1	6	1	2	0	0	0.910	1.000	1.000
541	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CCND1(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), E2F1(2), E2F2(3)	498773	12	7	10	14	2	2	1	5	2	0	0.999	1.000	1.000
542	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(3), TNF(3), TNFRSF1B(3)	611399	9	7	8	15	1	2	0	4	2	0	1.000	1.000	1.000
543	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), JAK1(2), JAK2(2), PTPRU(4), STAT1(1)	836344	10	7	9	25	2	4	0	4	0	0	1.000	1.000	1.000
544	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	6	JAK1(2), JAK2(2), JAK3(2), TYK2(3)	779117	9	7	9	18	4	1	0	4	0	0	1.000	1.000	1.000
545	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF1(2), CSF2(1), IL11(1), IL3(3), IL6(2), IL9(1)	460993	10	7	7	21	2	5	2	1	0	0	1.000	1.000	1.000
546	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), CD3G(2), IL2RA(1), TGFB2(1), TGFBR3(2)	785579	7	7	7	15	1	2	0	2	2	0	1.000	1.000	1.000
547	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), PPARG(3), TNF(3)	416737	7	7	6	11	0	1	0	4	2	0	1.000	1.000	1.000
548	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS2(1), CPO(5), UROS(1)	621764	9	6	7	16	2	5	0	2	0	0	1.000	1.000	1.000
549	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(1), ACYP1(1), ECHS1(1), EHHADH(3)	570606	8	6	7	10	0	4	0	4	0	0	0.999	1.000	1.000
550	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1B(3), PIK3CA(2), RAC1(1), WASL(1)	981086	7	6	6	10	2	1	0	4	0	0	0.999	1.000	1.000
551	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5)	514100	11	6	9	24	2	3	0	5	1	0	1.000	1.000	1.000
552	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	8	ACAA1(3), ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(3), HADHB(1)	559011	11	6	9	11	0	5	0	5	1	0	0.996	1.000	1.000
553	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(4), CYP11B2(5), HSD3B1(2), HSD3B2(2)	502862	13	6	10	16	6	3	3	0	1	0	0.998	1.000	1.000
554	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), PTK2B(4), SOS1(1)	636551	6	6	4	17	0	1	0	1	4	0	1.000	1.000	1.000
555	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS2(1), CPOX(1), PPOX(2), UROS(1)	568954	7	6	7	10	3	1	0	3	0	0	1.000	1.000	1.000
556	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5)	514100	11	6	9	24	2	3	0	5	1	0	1.000	1.000	1.000
557	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	6	EPHX2(6), HSD3B7(2)	301395	8	6	6	11	1	4	0	0	3	0	0.998	1.000	1.000
558	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	4	DDC(3), GOT2(4), TAT(2)	262381	9	6	8	11	4	2	0	3	0	0	0.997	1.000	1.000
559	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1), SRP68(1), SRP72(2), SRPR(1)	542736	6	6	6	13	3	1	0	1	1	0	1.000	1.000	1.000
560	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(1), IL1A(2), IL1R1(1), MYOG(1), NR4A3(1), WDR1(1)	810356	8	6	8	21	3	1	0	3	1	0	1.000	1.000	1.000
561	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	GH1(2), GHR(2), PIK3CA(2)	960523	6	6	6	19	0	2	0	2	2	0	1.000	1.000	1.000
562	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), CBS(2), CTH(2), MUT(5)	364148	10	6	7	6	6	1	0	3	0	0	0.834	1.000	1.000
563	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	CTSD(1), GREB1(6), TUBA8(3)	746783	10	6	9	12	6	2	0	2	0	0	0.992	1.000	1.000
564	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	7	ADORA1(1), ADORA3(4), P2RY1(1), P2RY6(1)	372877	7	6	6	6	2	1	0	4	0	0	0.943	1.000	1.000
565	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	BCL10(2), BCL2(1), CASP9(4)	777411	7	6	5	15	1	4	1	1	0	0	1.000	1.000	1.000
566	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC1B(3), RAC1(1), WASF1(1), WASL(1)	602723	6	6	5	6	3	0	0	3	0	0	0.979	1.000	1.000
567	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(2), GOT2(4), LDHA(1)	493188	7	5	5	12	1	1	0	5	0	0	1.000	1.000	1.000
568	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(3), GNAS(1), GNGT1(1), NFKB1(3), NPPA(1), PIK3CA(2)	1339315	11	5	9	23	3	4	0	2	2	0	1.000	1.000	1.000
569	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	7	COQ5(2), COQ6(2), COQ7(2)	261070	6	5	3	6	4	2	0	0	0	0	0.958	1.000	1.000
570	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(4), TAT(2)	191112	6	5	5	9	2	1	0	3	0	0	0.999	1.000	1.000
571	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	9	B3GALT5(1), B3GNT5(2), FUT1(1), FUT2(1), FUT3(6)	472874	11	5	8	8	2	3	0	6	0	0	0.958	1.000	1.000
572	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), GGPS1(1), IDI2(2), SQLE(1)	320695	6	5	6	12	0	0	2	1	3	0	1.000	1.000	1.000
573	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(2), CYP2C9(5)	144812	7	5	5	4	5	1	0	1	0	0	0.924	1.000	1.000
574	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	21	PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), PSMD13(1), PSMD2(1)	1133012	7	5	6	17	2	3	0	1	1	0	1.000	1.000	1.000
575	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR2(2), JAK1(2), JAK2(2), STAT1(1)	592569	7	5	6	21	1	4	0	2	0	0	1.000	1.000	1.000
576	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	3	PLCG1(3), PTK2B(4)	439247	7	5	4	16	0	1	2	1	3	0	1.000	1.000	1.000
577	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	OGDH(2), SDHA(6)	615626	8	5	6	22	5	0	0	3	0	0	1.000	1.000	1.000
578	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), FURIN(2), NOTCH1(2), PSEN1(1)	740733	6	5	6	12	4	1	0	0	1	0	0.999	1.000	1.000
579	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSS(1), POLD1(2), POLG(2), RRM1(1), SRM(1)	957892	7	5	6	15	2	2	1	2	0	0	1.000	1.000	1.000
580	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	IDH1(1), MDH2(5)	647342	6	5	4	9	1	4	1	0	0	0	0.996	1.000	1.000
581	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4)	997709	8	5	8	39	1	4	0	3	0	0	1.000	1.000	1.000
582	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(3), MBTPS1(1), SCAP(3), SREBF1(1), SREBF2(5)	931385	13	5	8	13	4	4	0	5	0	0	0.991	1.000	1.000
583	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MYC(7), SP1(1), SP3(2)	453360	10	5	10	9	0	5	1	4	0	0	0.971	1.000	1.000
584	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(2), LARS(4), PDHA2(2)	724252	8	5	5	24	0	7	1	0	0	0	1.000	1.000	1.000
585	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH4(4), ADH7(2), ADHFE1(1)	405117	7	4	4	11	0	2	1	2	2	0	0.999	1.000	1.000
586	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	GNAS(1), GNGT1(1), PPP2CA(1), PRKAA1(1), PRKACG(2)	1146405	6	4	5	21	2	2	0	2	0	0	1.000	1.000	1.000
587	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(3)	388880	5	4	3	7	1	4	0	0	0	0	0.983	1.000	1.000
588	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(7)	132232	7	4	5	4	4	3	0	0	0	0	0.794	1.000	1.000
589	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1G(1), HDAC9(1), MEF2B(3), MEF2C(1)	634155	6	4	5	23	2	1	0	2	1	0	1.000	1.000	1.000
590	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(3), SNCAIP(1)	451128	4	4	4	5	0	0	0	4	0	0	0.996	1.000	1.000
591	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	18	PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), RPN2(1)	910123	6	4	5	14	2	3	0	0	1	0	1.000	1.000	1.000
592	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1A(3)	452082	4	4	3	9	2	0	0	2	0	0	1.000	1.000	1.000
593	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(1), OXCT1(2)	248068	5	4	4	5	1	1	1	2	0	0	0.975	1.000	1.000
594	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	14	NDUFS1(1), NDUFS2(3)	483216	4	4	3	8	1	0	0	3	0	0	1.000	1.000	1.000
595	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	NRF1(1), UBE2D3(1), UBE2E3(1), UBE2J1(1)	748436	4	4	4	18	1	1	0	1	1	0	1.000	1.000	1.000
596	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(1), GNGT1(1), PRKACG(2)	732388	4	3	3	19	2	0	0	2	0	0	1.000	1.000	1.000
597	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(1), FUT2(1)	455083	3	3	3	6	2	0	0	1	0	0	0.996	1.000	1.000
598	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(3)	356381	4	3	4	4	0	3	0	1	0	0	0.933	1.000	1.000
599	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	OPRK1(1), PRKACG(2)	943548	3	3	2	27	1	0	0	2	0	0	1.000	1.000	1.000
600	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(1), HK1(1)	674641	3	3	3	9	0	2	0	1	0	0	1.000	1.000	1.000
601	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	GNAS(1), GNGT1(1), PRKACA(1)	489989	3	3	3	6	3	0	0	0	0	0	0.998	1.000	1.000
602	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), UXS1(1)	371833	3	3	2	8	0	3	0	0	0	0	0.999	1.000	1.000
603	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), UXS1(1)	296956	3	3	2	8	0	3	0	0	0	0	0.999	1.000	1.000
604	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP8(3)	276675	4	3	4	11	2	0	0	1	1	0	1.000	1.000	1.000
605	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), THBS1(5)	517679	6	3	4	15	0	4	0	1	1	0	1.000	1.000	1.000
606	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	KEAP1(1), MAPK8(1)	680914	2	2	2	13	0	1	1	0	0	0	1.000	1.000	1.000
607	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	2	FAH(1), HGD(1)	128704	2	2	2	3	1	0	0	1	0	0	0.968	1.000	1.000
608	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(2)	372890	2	2	1	13	2	0	0	0	0	0	1.000	1.000	1.000
609	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	6	ST6GALNAC2(1)	302151	1	1	1	5	1	0	0	0	0	0	0.999	1.000	1.000
610	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(1)	273918	1	1	1	7	1	0	0	0	0	0	1.000	1.000	1.000
611	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB9A(1)	312573	1	1	1	6	0	1	0	0	0	0	1.000	1.000	1.000
612	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(1)	260296	1	1	1	5	0	0	1	0	0	0	0.999	1.000	1.000
613	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		121917	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		36378	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		156741	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		109350	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
