rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT1(3), GOT2(2), TAT(1), TYR(5)	3135385	13	13	13	1	1	0	3	4	5	0	0.272	0.00415	1.000
2	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	16	ADCY1(2), GNAS(5), GNB1(2), PPP2CA(1), PRKAB1(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAG2(4), PRKAR1A(2), PRKAR2B(2)	9130690	27	27	27	1	3	3	2	12	7	0	0.0153	0.00863	1.000
3	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(6), EGF(4), EGFR(9), HGS(2), RAB5A(1), TFRC(2)	8444563	24	23	22	0	4	1	5	6	8	0	0.00556	0.0108	1.000
4	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(1), AKT2(3), AKT3(1), CDKN1A(1), ELK1(1), GRB2(2), HRAS(1), NGFR(1), NTRK1(5), PIK3CD(1), SHC1(3), SOS1(5)	8805146	25	24	24	1	2	6	2	12	3	0	0.0101	0.0151	1.000
5	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(1), GOT1(3), GOT2(2), LDHB(1), LDHC(3), MPST(2)	4479216	18	18	16	2	1	0	2	5	10	0	0.390	0.0168	1.000
6	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PDXK(2), PDXP(1), PSAT1(1)	3151763	11	11	11	0	2	1	0	6	2	0	0.0942	0.0182	1.000
7	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(4), CPS1(4), GLS(3), GOT1(3)	5133932	15	15	15	1	0	3	1	6	5	0	0.175	0.0413	1.000
8	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(6), ACO1(4), ACSS1(2), ACSS2(7), IDH1(2), IDH2(5), MDH1(1), SUCLA2(1)	8812773	28	23	24	2	1	5	3	8	10	1	0.0484	0.0583	1.000
9	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(5), GNB1(2), PRKACA(1), PRKAR1A(2)	4071859	12	12	12	1	1	1	0	9	1	0	0.287	0.0635	1.000
10	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(4)	3459591	11	11	11	2	1	1	1	4	3	1	0.531	0.0647	1.000
11	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(2), CD3E(1), CD3G(2), CREBBP(5), CSK(3), GNAS(5), GNB1(2), HLA-DRA(1), HLA-DRB1(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTPRC(6)	13841274	36	33	36	1	4	2	2	19	9	0	0.00493	0.0672	1.000
12	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(2), CD3E(1), CD3G(2), CREBBP(5), CSK(3), GNAS(5), GNB1(2), HLA-DRA(1), HLA-DRB1(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTPRC(6)	13841274	36	33	36	1	4	2	2	19	9	0	0.00493	0.0672	1.000
13	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(1)	1757669	6	6	6	1	1	0	2	0	3	0	0.569	0.0674	1.000
14	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(18), MAP2(4), PPP2CA(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAR2B(2), PRKCE(2)	12102647	35	33	32	3	4	2	2	13	13	1	0.0464	0.0693	1.000
15	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ALDOB(3), ENO1(3), HK1(5), PFKL(1), PGK1(3), TPI1(1)	5118923	16	15	16	2	3	2	2	4	5	0	0.149	0.0709	1.000
16	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(9), MAP3K1(5), MAPK14(1), NCOR2(6), RARA(4), THRA(1)	11146341	30	26	28	2	2	4	5	8	11	0	0.0288	0.0806	1.000
17	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	12	CD2(2), CD34(2), CD3E(1), CD3G(2), CD8A(1), IL3(1), KITLG(2)	3521831	11	10	11	1	1	1	1	4	4	0	0.364	0.0934	1.000
18	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), CREM(1), FHL5(2), FSHR(2), GNAS(5), XPO1(5)	6080934	17	17	17	2	3	1	3	7	3	0	0.226	0.0940	1.000
19	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	15	ABCB1(4), AKT1(1), ATM(15), CDKN1A(1), CSNK1A1(2), FHL2(1), HIF1A(3), IGFBP3(1), NFKBIB(1)	11998628	29	26	29	2	0	4	4	8	13	0	0.0408	0.110	1.000
20	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(5), HADHA(2)	3225085	9	9	8	0	1	3	2	1	2	0	0.0459	0.113	1.000
21	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(1), HLA-DRA(1), HLA-DRB1(1)	748139	3	3	3	0	1	0	0	0	2	0	0.699	0.119	1.000
22	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(1), ACADS(3), ECHS1(2), HADHA(2)	3565989	8	8	7	0	3	1	3	1	0	0	0.0479	0.120	1.000
23	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), ADRB2(2), GNAS(5), PLCE1(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RAP2B(2)	9420366	22	22	22	2	3	1	2	9	7	0	0.147	0.129	1.000
24	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(2)	778537	3	3	3	0	0	0	1	1	1	0	0.585	0.138	1.000
25	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(2), CD28(1), CD3E(1), CD3G(2), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6)	6762553	19	18	19	2	1	2	2	9	5	0	0.198	0.170	1.000
26	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), GLI2(4), GLI3(5), GSK3B(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), SHH(1), SMO(3), SUFU(1)	10138090	27	26	25	3	5	3	2	10	7	0	0.0575	0.190	1.000
27	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(9), ERBB3(4), NRG1(1), UBE2D1(2)	6806238	20	20	18	3	3	1	2	6	8	0	0.353	0.191	1.000
28	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	9	ACACA(6), CPT1A(1), LEP(1), LEPR(1), PRKAB1(1), PRKAG1(4), PRKAG2(4)	8982151	18	18	18	1	1	4	4	3	6	0	0.0265	0.191	1.000
29	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(5), HADH(1), HADHA(2), SIRT1(3), SIRT5(1), SIRT7(2), VNN2(1)	7846258	17	16	16	1	3	4	3	2	5	0	0.0309	0.195	1.000
30	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	5	ABCB1(4), ABCB11(3), ABCB4(5), ABCC3(7)	7632041	19	18	16	1	0	3	4	6	6	0	0.0478	0.196	1.000
31	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6)	6954807	20	18	20	2	1	3	2	9	5	0	0.144	0.202	1.000
32	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), FPGS(2)	3825796	12	11	12	2	1	3	1	6	1	0	0.241	0.208	1.000
33	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	11	CCNA1(7), CCNE1(1), CCNE2(2), CDK2(2), CDKN2A(3), E2F1(1)	4963063	16	15	12	2	0	1	2	1	12	0	0.361	0.208	1.000
34	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	ARF1(1), ARF3(1), CDK2(2), CDKN1A(1), CDKN2A(3), CFL1(1), E2F1(1)	3948557	10	10	10	2	0	0	2	2	6	0	0.602	0.220	1.000
35	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(1), AKT2(3), AKT3(1), GRB2(2), ILK(4), MAPK3(1), PDK1(1), PIK3CD(1), PTK2B(3), RBL2(2), SHC1(3), SOS1(5)	11294224	27	24	25	2	3	7	3	6	8	0	0.0284	0.222	1.000
36	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), GSS(1), NFKB1(1), NOX1(6), RELA(5), XDH(5)	6455005	19	16	14	1	1	2	3	4	8	1	0.149	0.223	1.000
37	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CD28(1), CD3E(1), CD3G(2)	1554162	4	4	4	0	1	0	1	1	1	0	0.420	0.229	1.000
38	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(2), IFNGR2(2), JAK1(4), JAK2(5), STAT1(3)	5533825	16	16	16	3	1	0	2	6	7	0	0.562	0.233	1.000
39	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(2), AASS(4)	4697753	10	10	10	0	0	2	1	3	4	0	0.160	0.237	1.000
40	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(1), CDC25B(1), CDC25C(2), MNAT1(1), SHH(1), XPO1(5)	5730976	12	12	12	1	0	1	4	6	1	0	0.151	0.240	1.000
41	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	9	ECHS1(2), EHHADH(5), HADHA(2), SDHB(1)	4585957	10	10	9	0	1	3	3	1	2	0	0.0345	0.242	1.000
42	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(1), CD3G(2), FYN(2), HLA-DRA(1), HLA-DRB1(1), PTPRC(6)	5093230	13	12	13	0	0	1	1	7	4	0	0.133	0.243	1.000
43	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ECHS1(2), EHHADH(5), HADHA(2), HADHB(3)	5572378	12	12	11	0	1	4	3	2	2	0	0.0187	0.243	1.000
44	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(3), GLS2(4)	2902056	7	7	7	0	0	1	0	5	1	0	0.273	0.243	1.000
45	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	HRAS(1), MMP14(1), MMP2(6), MMP9(1), RECK(1)	4657435	10	10	10	1	2	2	1	3	2	0	0.203	0.243	1.000
46	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(5), EP300(11), NCOA3(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RARA(4)	13385859	33	31	30	3	3	1	7	13	9	0	0.0207	0.259	1.000
47	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(2), AASS(4)	3196928	7	7	7	0	0	1	1	2	3	0	0.273	0.272	1.000
48	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HRAS(1), PTK2B(3), SHC1(3), SOS1(5), SRC(1)	5690638	15	13	15	2	1	5	1	5	3	0	0.252	0.274	1.000
49	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(4), GNA12(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAR2B(2)	6577458	15	15	15	2	2	2	3	5	3	0	0.189	0.275	1.000
50	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE3A(1)	6888798	13	13	13	1	1	2	1	5	4	0	0.163	0.288	1.000
51	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(1), HLA-DRA(1), HLA-DRB1(1), IL4(1)	1810951	4	4	4	1	1	0	1	0	2	0	0.750	0.295	1.000
52	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	9	EPX(2), PRDX1(1), PRDX5(1), TPO(4), TYR(5)	5379803	13	12	13	1	0	2	1	6	4	0	0.235	0.303	1.000
53	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2)	3778160	8	8	7	1	1	0	0	5	2	0	0.569	0.306	1.000
54	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(1), CD3G(2), ICAM1(1), ITGAL(5), ITGB2(1), PRF1(1)	5356831	13	12	13	1	0	3	2	4	4	0	0.142	0.307	1.000
55	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	481049	1	1	1	0	0	0	1	0	0	0	0.751	0.311	1.000
56	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(2), EGF(4), EGFR(9), GRB2(2), HRAS(1), MAPK3(1), PTPRB(3), RAF1(1), RASA1(3), SHC1(3), SOS1(5), SPRY1(1), SPRY2(2), SRC(1)	16181333	38	32	36	4	4	10	5	10	9	0	0.0281	0.314	1.000
57	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), ADRB2(2), CFTR(4), GNAS(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	8295712	21	21	21	3	3	2	0	11	5	0	0.317	0.314	1.000
58	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(1), GLS(3), OAT(1), PRODH(1)	3619832	7	7	7	0	0	1	3	2	1	0	0.148	0.316	1.000
59	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(3), LUM(1)	2353850	7	7	7	2	0	1	0	4	2	0	0.683	0.319	1.000
60	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(7), CR2(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6)	9718536	24	23	24	3	1	2	1	12	8	0	0.275	0.326	1.000
61	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(1), IKBKB(1), IL4(1), JUN(2), MAP3K1(5), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(1), RELA(5), TNFRSF9(1), TNFSF9(1), TRAF2(1)	13014003	30	26	27	3	0	4	1	11	13	1	0.224	0.345	1.000
62	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(2), GLB1(5), GNS(1), GUSB(5), HEXA(3), IDS(2), IDUA(1), LCT(2), NAGLU(2)	9307263	24	21	24	3	2	3	3	9	7	0	0.0919	0.349	1.000
63	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), HPRT1(1), IMPDH1(1), POLB(1), POLD1(6), POLG(4), PRPS2(3), RRM1(2)	8012839	19	18	17	2	2	4	1	5	7	0	0.162	0.350	1.000
64	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ6(1), NDUFA13(2)	2720684	5	5	5	0	2	1	0	1	1	0	0.218	0.351	1.000
65	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	1021533	2	2	2	1	0	0	0	1	1	0	0.880	0.367	1.000
66	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), FOS(1), JUN(2), MAPK3(1), POLR2A(8), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	8295387	21	20	21	3	6	2	2	6	5	0	0.134	0.379	1.000
67	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB6(1), NDUFS1(5), NDUFS2(1), NDUFV1(1), NDUFV2(1)	4638002	12	12	12	2	0	1	1	7	3	0	0.529	0.382	1.000
68	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(4), EGF(4), EGFR(9), GRB2(2), MET(6), PDGFRA(5), PRKCA(2), SH3GLB1(2), SH3GLB2(1), SH3KBP1(1), SRC(1)	12895146	39	36	36	5	3	5	4	13	14	0	0.130	0.398	1.000
69	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	6	FOS(1), FYN(2), JUN(2), MAPK14(1)	3175627	6	6	6	1	1	1	0	4	0	0	0.538	0.399	1.000
70	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), NFKB1(1), RELA(5)	8256148	19	18	16	2	0	4	1	6	7	1	0.183	0.402	1.000
71	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(2), SHMT1(2), SHMT2(3)	2637325	7	7	7	2	0	1	1	2	3	0	0.687	0.403	1.000
72	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), IDH1(2), IDH2(5), MDH1(1), SDHB(1), SUCLA2(1)	5926418	14	13	11	2	1	2	1	5	5	0	0.368	0.409	1.000
73	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(1), CAMK1G(3), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(2), CAMKK2(2), SYT1(1)	7576560	15	15	14	0	1	1	2	6	5	0	0.0570	0.411	1.000
74	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(1), ENO3(2), GOT1(3), GOT2(2), PAH(3), TAT(1), YARS(1)	5536066	16	14	16	3	2	1	4	3	6	0	0.376	0.414	1.000
75	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(1), ENPP3(1), NADSYN1(1), NMNAT2(2), NNMT(1), NNT(6), NT5M(2), QPRT(1)	9614289	22	22	22	3	1	2	3	12	4	0	0.165	0.419	1.000
76	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	5	HDAC1(2), SP1(2), SP3(2), WT1(3)	3610012	9	9	9	2	0	1	0	5	3	0	0.719	0.429	1.000
77	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(1), C1R(3), C2(4), C3(6), C5(5), C6(1), C7(3), C8A(1)	10533806	24	23	22	3	3	4	1	10	5	1	0.122	0.439	1.000
78	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	1107719	2	2	2	1	0	1	0	1	0	0	0.763	0.443	1.000
79	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(1), RDH11(3)	3085748	6	6	6	0	1	0	1	4	0	0	0.235	0.445	1.000
80	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(6), CS(2), MDH1(1), ME1(1), PC(3), PDHA1(1), SLC25A11(1)	6003931	15	15	15	2	1	3	0	6	5	0	0.204	0.456	1.000
81	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	11	ACTR2(1), CDC42(1), PAK1(2), PDGFRA(5), PIK3R1(2)	6426104	11	11	11	1	0	2	1	5	3	0	0.343	0.490	1.000
82	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(5), GNB1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2)	6151940	17	16	17	3	2	2	0	9	4	0	0.417	0.490	1.000
83	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(2), DHRS2(1), PON3(4), RDH11(3)	5418680	10	10	9	1	1	0	3	4	2	0	0.364	0.493	1.000
84	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(1), CD3G(2), IL2RA(2), IL4(1), TGFB2(1), TGFBR2(1), TGFBR3(3), TOB1(2), TOB2(3)	7049851	17	17	17	3	1	2	4	4	6	0	0.336	0.495	1.000
85	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR171(1), GPR39(1), GPR45(3), GPR65(3), GPR75(1)	6370681	10	10	10	1	1	2	0	4	2	1	0.0882	0.501	1.000
86	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(2), GLB1(5), GNS(1), GUSB(5), HEXA(3), HGSNAT(1), HPSE(1), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), NAGLU(2), SPAM1(6)	13332496	37	31	37	5	4	6	4	15	8	0	0.0359	0.519	1.000
87	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB1A(2), RAB3A(1), RAB4A(1), RAB5A(1)	2793408	5	5	5	0	1	0	1	1	2	0	0.222	0.523	1.000
88	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), DNAJC3(2), EIF2S2(2), NFKB1(1), RELA(5)	6021957	11	11	8	0	0	4	0	2	4	1	0.128	0.529	1.000
89	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(1), ALDOB(3), TPI1(1)	2534776	5	5	5	3	0	0	1	0	4	0	0.993	0.534	1.000
90	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1B(1), BMPR2(5)	4067154	9	7	9	0	0	1	2	4	2	0	0.0715	0.538	1.000
91	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), FOS(1), GRB2(2), HRAS(1), IL3(1), JAK2(5), MAPK3(1), PTPN6(3), RAF1(1), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2)	11441752	28	26	27	4	4	3	3	10	8	0	0.175	0.542	1.000
92	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(3), GPRC5A(1), GPRC5B(2), GPRC5C(1), GRM1(4), GRM2(2), GRM3(3), GRM4(3), GRM5(7), GRM7(4), GRM8(2)	12621622	37	31	34	5	4	5	3	14	11	0	0.136	0.546	1.000
93	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(2)	1497521	3	3	3	1	0	0	1	0	2	0	0.902	0.568	1.000
94	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), IFNAR1(2), IFNB1(2), NFKB1(1), RELA(5), TRAF6(2)	7067516	13	13	10	1	1	5	0	1	5	1	0.250	0.581	1.000
95	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(3), UXS1(1)	2648399	4	4	4	1	0	1	2	1	0	0	0.620	0.585	1.000
96	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(2), AKT1(1), CALM2(1), GNAS(5), GNB1(2), NFKB1(1), NOS3(2), NPPA(1), PIK3R1(2), RELA(5), SYT1(1)	10055532	23	22	20	3	1	6	0	8	7	1	0.259	0.586	1.000
97	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1), HLA-DRB1(1), IL3(1)	1780309	3	3	3	0	0	0	0	0	3	0	0.826	0.588	1.000
98	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(3), UGP2(1), UXS1(1)	3354142	5	5	5	1	0	1	3	1	0	0	0.488	0.592	1.000
99	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1)	2183565	4	4	4	1	0	0	0	2	2	0	0.892	0.605	1.000
100	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(1), CDK2(2), CUL1(3), E2F1(1), RB1(2), SKP2(1)	5788222	17	17	14	3	0	2	2	2	11	0	0.357	0.612	1.000
101	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), EIF4E(1), FBL(1), GPT(2), LDHB(1), LDHC(3), MAPK14(1), NCL(3)	5863439	17	15	16	4	0	0	4	6	7	0	0.682	0.615	1.000
102	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(1), C1R(3), C2(4), C3(6), C5(5), C6(1), C7(3), C8A(1), MASP1(2), MASP2(1), MBL2(1)	13079129	28	27	26	4	5	5	1	11	5	1	0.0913	0.616	1.000
103	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(3), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1)	6720053	14	12	14	2	0	3	2	5	4	0	0.266	0.628	1.000
104	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(1), CASP9(1), CHUK(1), GHR(1), NFKB1(1), PIK3R1(2), PPP2CA(1), RELA(5)	7868555	13	13	10	0	0	4	0	3	5	1	0.0616	0.641	1.000
105	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	FOSB(1), GRIA2(3), PPP1R1B(1)	2312513	5	5	5	2	1	1	0	3	0	0	0.748	0.646	1.000
106	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(2), HADH(1), HADHA(2), HADHB(3), MECR(1)	5555699	9	8	9	0	1	2	3	3	0	0	0.0521	0.647	1.000
107	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(2), CASP8(1), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	5178481	9	9	9	2	0	3	3	2	1	0	0.405	0.649	1.000
108	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(1), C1R(3), C2(4), C3(6), C5(5), C6(1), C7(3), C8A(1), C8B(1), MASP1(2)	12731512	27	26	25	4	6	4	1	10	5	1	0.109	0.650	1.000
109	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(1)	2735789	4	4	4	1	0	1	1	0	2	0	0.815	0.654	1.000
110	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), IDI1(1), IDI2(1)	2908836	5	5	5	1	0	0	0	2	3	0	0.831	0.656	1.000
111	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(1), CFLAR(1)	2545277	3	3	3	1	0	0	2	0	1	0	0.770	0.662	1.000
112	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	10437781	19	19	19	2	3	0	0	8	8	0	0.140	0.666	1.000
113	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(1)	1058489	1	1	1	1	0	0	1	0	0	0	0.943	0.666	1.000
114	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	3	RAN(1), RANGAP1(1)	1313191	2	2	2	0	0	1	0	0	1	0	0.585	0.669	1.000
115	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNA1(1), IFNB1(2), IKBKB(1), IL1B(1), IL1R1(1), IL1RAP(4), IRAK1(3), IRAK3(3), JUN(2), MAP2K3(2), MAP3K1(5), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TGFB2(1), TRAF6(2)	19456804	37	34	33	3	3	10	0	12	11	1	0.0228	0.670	1.000
116	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD2(1), GGT1(2)	3696433	5	5	5	1	0	0	2	1	2	0	0.469	0.672	1.000
117	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CTH(1), GGT1(2), MARS(2), MARS2(3), PAPSS1(2), PAPSS2(2), SCLY(2), SEPHS1(1)	7909012	16	16	16	3	2	0	5	4	5	0	0.314	0.680	1.000
118	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	5	GBA(2), GGT1(2), SHMT1(2), SHMT2(3)	3181195	9	9	9	4	0	1	1	3	4	0	0.865	0.689	1.000
119	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK14(1), NFKB1(1), RELA(5), TNFRSF13B(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(2)	9546530	16	15	13	1	0	4	0	6	5	1	0.183	0.692	1.000
120	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CTH(1), MUT(2)	3173931	4	4	4	0	1	0	1	0	2	0	0.468	0.695	1.000
121	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(2), STX1A(1), VAMP2(1)	2113258	4	4	4	3	0	0	0	1	3	0	0.986	0.706	1.000
122	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1070228	1	1	1	0	0	0	0	1	0	0	0.838	0.711	1.000
123	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(1), ITGAL(5), ITGAM(5), ITGB2(1), SELE(4)	6986089	18	18	18	4	0	6	2	4	6	0	0.285	0.713	1.000
124	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDK2(2), CUL1(3), E2F1(1), NEDD8(2), RB1(2), SKP2(1)	5746773	12	12	11	2	0	1	1	2	8	0	0.519	0.714	1.000
125	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(6), IL3(1), KITLG(2), TGFB2(1)	5477520	11	11	11	2	0	1	1	4	5	0	0.608	0.715	1.000
126	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG12(1), ATG3(1), ATG7(4), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), PIK3C3(2), PIK3R4(4), ULK1(1), ULK2(1)	12722611	24	23	24	3	2	2	1	14	5	0	0.222	0.724	1.000
127	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(4), EIF2B5(2), EIF2S2(2), EIF5(2), GSK3B(3)	7634764	15	14	13	2	0	1	2	4	8	0	0.425	0.733	1.000
128	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	1344260	3	3	3	2	0	2	0	1	0	0	0.868	0.735	1.000
129	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	12	ADH5(1), CAT(2), EPX(2), PRDX1(1), PRDX5(1), SHMT1(2), SHMT2(3), TPO(4)	6758981	16	15	16	3	0	3	2	6	5	0	0.433	0.742	1.000
130	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ICAM1(1), ITGA4(2), ITGAL(5), ITGB1(4), ITGB2(1), SELE(4)	8049451	19	18	19	4	0	5	3	5	6	0	0.325	0.763	1.000
131	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), ATIC(2), FTCD(2), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(1), SHMT1(2), SHMT2(3)	12548008	22	21	22	3	3	4	0	10	5	0	0.181	0.770	1.000
132	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(4), ANKRD1(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(2), WDR1(1)	7034714	11	11	11	2	0	3	2	3	3	0	0.387	0.779	1.000
133	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(1), CNR2(2), MTNR1B(1), PTAFR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), TBXA2R(2)	4663794	13	13	13	4	1	2	0	6	4	0	0.684	0.783	1.000
134	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2)	2037938	2	2	2	1	0	1	0	1	0	0	0.891	0.784	1.000
135	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C5(5), C6(1), C7(3), C8A(1)	8544986	16	16	16	3	2	2	1	8	3	0	0.325	0.785	1.000
136	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDKN1A(1), NEK1(3), WEE1(1)	4906037	7	6	7	1	0	2	0	3	2	0	0.447	0.796	1.000
137	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(2), IFNGR2(2), IL12RB1(2), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(2)	8183213	18	17	18	4	4	1	1	5	7	0	0.531	0.799	1.000
138	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(2), JAK1(4), JAK2(5), PTPRU(4), STAT1(3)	7501440	18	16	18	4	2	0	2	9	5	0	0.570	0.800	1.000
139	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(5), RPE(1), UCHL3(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2)	11577235	25	22	25	4	2	5	3	5	10	0	0.253	0.802	1.000
140	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(1), CASP9(1), CDC42(1), CHUK(1), ELK1(1), HRAS(1), MAPK3(1), NFKB1(1), PIK3R1(2), RAF1(1), RALA(2), RALBP1(1), RELA(5)	11107607	19	19	15	2	1	5	0	5	7	1	0.235	0.805	1.000
141	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(2), CASP9(1), DAXX(5), FAS(1), HSPB2(2), MAPKAPK2(1)	7180948	12	12	12	2	2	1	0	7	2	0	0.359	0.807	1.000
142	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(4), ARHGDIB(1), CASP1(2), CASP10(2), CASP8(1), CASP9(1), JUN(2), PRF1(1)	8351688	16	15	16	3	0	3	1	7	5	0	0.481	0.807	1.000
143	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), AP2A1(2), BIN1(1), CALM2(1), DNM1(1), EPN1(1), EPS15(1), PICALM(1), PPP3CA(2), PPP3CC(3), SYNJ1(5), SYNJ2(5), SYT1(1)	14557266	27	27	27	4	1	6	1	12	7	0	0.166	0.808	1.000
144	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), ATIC(2), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(1), SHMT1(2), SHMT2(3)	11867713	20	19	20	3	3	4	0	8	5	0	0.224	0.809	1.000
145	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(2), POLR2A(8), POLR2B(4), POLR2I(1), POLRMT(2)	8367089	17	16	17	3	1	4	4	3	5	0	0.193	0.811	1.000
146	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(9)	10720371	26	23	24	3	2	0	0	11	13	0	0.315	0.811	1.000
147	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), RPN1(2), RPN2(1), UBE2A(2), UBE3A(1)	8767774	17	17	17	3	0	1	2	8	6	0	0.577	0.814	1.000
148	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(2), FDPS(1), IDI1(1), LSS(2), MVK(1), PMVK(1), VKORC1(1)	7266876	11	11	11	1	0	0	1	7	3	0	0.460	0.814	1.000
149	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(7), AXIN1(2), BTRC(2), CREBBP(5), CSNK1A1(2), CTBP1(1), CTNNB1(1), DVL1(1), FZD1(1), GSK3B(3), HDAC1(2), MAP3K7(1), PPARD(1), PPP2CA(1), TLE1(4), WIF1(4)	18971371	38	34	32	3	2	2	5	14	15	0	0.0177	0.817	1.000
150	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(1), HSD3B1(1)	5329177	6	6	6	0	1	1	2	2	0	0	0.138	0.832	1.000
151	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(1), CSNK1A1(2), GSK3B(3), MAPT(3), PPP2CA(1)	6119567	10	10	8	0	0	1	1	1	7	0	0.108	0.836	1.000
152	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(1), CD3E(1), CD3G(2), CD86(1), CTLA4(1), GRB2(2), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(1), PIK3R1(2), PTPN11(1)	6845113	16	16	15	3	1	3	1	4	7	0	0.634	0.841	1.000
153	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1), SPCS1(1)	2028703	2	2	2	1	0	0	0	1	1	0	0.869	0.847	1.000
154	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), GRB2(2), IL4(1), IL4R(2), IRS1(4), JAK1(4), JAK3(3), RPS6KB1(2), SHC1(3), STAT6(4)	9209886	26	24	26	5	4	3	4	8	7	0	0.294	0.855	1.000
155	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), IL4(1), JUNB(1), MAF(1), MAP2K3(2), MAPK14(1), NFATC1(2), NFATC2(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	7255388	23	22	21	5	4	0	1	10	8	0	0.439	0.864	1.000
156	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(5), NFKB1(1), RELA(5), TRAF3(1), TRAF6(2)	12025983	18	16	15	1	0	5	0	3	9	1	0.108	0.867	1.000
157	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	1350624	1	1	1	1	0	0	0	1	0	0	0.940	0.867	1.000
158	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(5), EP300(11), IKBKB(1), NFKB1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF6(2)	14388684	30	26	24	4	1	4	6	5	13	1	0.165	0.869	1.000
159	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACOX1(1), ACOX3(2), ELOVL2(1), FADS2(2), FASN(3), HADHA(2), PECR(1)	8633808	12	11	12	2	3	2	2	5	0	0	0.177	0.871	1.000
160	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(4), AKT1(1), AKT2(3), AKT3(1), APAF1(2), ATM(15), BID(1), BIRC2(2), BIRC3(2), CAPN1(1), CAPN2(2), CASP10(2), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), CSF2RB(1), DFFB(1), FAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(3), IRAK4(1), NFKB1(1), NFKB2(1), NTRK1(5), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RELA(5), RIPK1(1), TNFRSF10C(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	52313396	105	85	99	11	8	16	11	40	29	1	0.000723	0.872	1.000
161	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(3), HDAC9(2), MEF2D(1)	5358220	7	7	6	1	1	0	0	2	4	0	0.614	0.873	1.000
162	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(3), EXT2(1), EXTL1(1), EXTL3(3), GLCE(1), HS2ST1(1), HS3ST2(1), HS3ST5(1), HS6ST1(1), HS6ST2(1), NDST1(2), NDST2(3), NDST4(5)	12751950	24	23	23	3	2	4	3	7	8	0	0.134	0.874	1.000
163	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(5), EP300(11), LPL(2), NCOA1(2), NCOA2(9), PPARG(2)	12108595	31	23	22	4	2	1	4	8	16	0	0.0951	0.887	1.000
164	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(4), PCYT1A(1), PDHA1(1), PDHA2(2), SLC18A3(1)	4258777	10	10	8	3	0	2	0	2	6	0	0.887	0.889	1.000
165	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), GBGT1(2), GLA(1), HEXA(3), ST3GAL1(1), ST8SIA1(2)	6814216	10	10	10	2	1	2	1	5	1	0	0.313	0.889	1.000
166	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(5), AGT(1), AGTR1(2), BDKRB2(1), KNG1(2), NOS3(2), REN(1)	6220091	14	13	12	3	1	3	1	3	6	0	0.454	0.889	1.000
167	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDK2(2), CUL1(3), E2F1(1), FBXW7(2), RB1(2)	5632778	11	11	11	3	0	1	1	2	7	0	0.709	0.891	1.000
168	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	DHRS2(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3)	9191150	13	12	13	1	1	2	2	5	3	0	0.215	0.892	1.000
169	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(2), FDFT1(2), FDPS(1), HMGCS1(1), IDI1(1), LSS(2), MVK(1), NSDHL(3), PMVK(1)	8670732	14	12	14	1	0	2	1	7	4	0	0.244	0.896	1.000
170	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), CREBBP(5), DFFB(1), PRF1(1)	6823412	9	8	9	0	2	1	2	2	2	0	0.0619	0.897	1.000
171	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(1), ARRB2(1), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA1(1), CLCA4(2), CNGA3(3), CNGA4(2), CNGB1(6), PDC(1), PDE1C(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKG1(3), PRKG2(2)	20348083	36	34	33	4	5	5	2	14	10	0	0.0703	0.899	1.000
172	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(1), EPHB1(1), FYN(2), ITGA1(5), ITGB1(4), L1CAM(5), SELP(2)	10345754	20	19	19	4	2	2	2	8	6	0	0.367	0.900	1.000
173	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25B(1), CDC25C(2), CSK(3), GRB2(2), PRKCA(2), PTPRA(3), SRC(1)	6030235	15	13	15	4	0	5	1	6	3	0	0.505	0.903	1.000
174	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	14	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1B1(1), ALDH2(2), ALDH7A1(1)	8160179	13	13	12	3	1	1	0	7	4	0	0.659	0.905	1.000
175	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), RDH5(2)	2542945	4	4	4	2	0	0	2	1	1	0	0.861	0.908	1.000
176	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFB(1), TOP2A(4), TOP2B(1)	6729138	7	7	7	0	2	1	0	2	2	0	0.240	0.909	1.000
177	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	43	ABAT(1), ACADM(1), ACADS(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOX1(7), BCAT1(1), BCKDHA(1), DLD(2), ECHS1(2), EHHADH(5), HADH(1), HADHA(2), HADHB(3), HIBADH(1), HMGCS1(1), HMGCS2(1), IVD(2), MCCC1(2), MCCC2(3), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(3)	27910135	51	50	49	6	4	6	11	18	12	0	0.0192	0.910	1.000
178	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(15), ATR(7), CDC25C(2), CHEK2(1)	10191584	25	22	25	6	0	3	2	9	11	0	0.717	0.916	1.000
179	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	13	APAF1(2), ATM(15), CCNE1(1), CDK2(2), CDKN1A(1), E2F1(1), PCNA(2), RB1(2)	10854152	26	22	26	6	0	3	3	6	14	0	0.542	0.917	1.000
180	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(2), PAPSS2(2), SULT2A1(1), SUOX(4)	4078790	9	9	9	3	1	0	3	1	4	0	0.701	0.919	1.000
181	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CASP2(1), CHUK(1), IKBKB(1), JUN(2), LTA(1), MAP2K3(2), MAP3K1(5), MAPK14(1), NFKB1(1), RELA(5), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	15660452	28	25	25	4	1	4	2	11	9	1	0.305	0.920	1.000
182	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), NDUFA1(1), SDHA(1), SDHB(1), SDHD(1), UQCRC1(1)	4300772	7	6	7	2	1	2	1	3	0	0	0.532	0.921	1.000
183	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), GCNT2(2), ST8SIA1(2)	3802567	5	5	5	2	1	1	1	2	0	0	0.646	0.923	1.000
184	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(4), POLR1B(2), POLR1C(2), POLR2A(8), POLR2B(4), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1)	15313351	31	28	31	4	1	5	3	14	8	0	0.0927	0.927	1.000
185	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(5), KHK(3), LCT(2), MPI(1), PYGL(1), PYGM(3), TPI1(1)	8882163	16	15	16	3	4	0	3	6	3	0	0.278	0.927	1.000
186	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNB1(2), JAK1(4), STAT1(3), STAT2(6), TYK2(6)	7056471	24	20	23	6	2	5	3	5	9	0	0.427	0.929	1.000
187	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(3)	8497018	16	16	16	4	3	1	1	10	1	0	0.454	0.930	1.000
188	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(1), IFNGR1(2), IFNGR2(2), IKBKB(1), JAK2(5), NFKB1(1), RB1(2), RELA(5), TNFRSF1A(1), USH1C(3), WT1(3)	11175025	26	25	23	6	0	3	2	6	14	1	0.721	0.932	1.000
189	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C5(5), C6(1), C7(3), ICAM1(1), ITGA4(2), ITGAL(5), ITGB1(4), ITGB2(1), SELP(2), SELPLG(2), VCAM1(3)	16371292	35	33	35	7	3	5	5	15	7	0	0.181	0.933	1.000
190	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	CHST11(1), CHST12(2), PAPSS1(2), PAPSS2(2), SULT1A1(1), SULT2A1(1), SUOX(4)	5671732	13	13	13	4	2	1	3	1	6	0	0.745	0.934	1.000
191	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(2), LCMT1(1), LCMT2(3), PCYT1A(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3)	9072873	15	14	15	2	1	2	1	6	5	0	0.481	0.935	1.000
192	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	2272771	1	1	1	1	0	0	0	0	1	0	0.967	0.936	1.000
193	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(1), CAMK1G(3), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), MEF2D(1), PPP3CA(2), PPP3CC(3), SYT1(1)	13416740	17	17	16	1	2	1	1	5	8	0	0.116	0.936	1.000
194	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(2), PPARG(2), RETN(1)	3623001	5	5	5	2	1	1	0	1	2	0	0.732	0.936	1.000
195	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(6)	6769437	18	18	17	5	1	0	3	6	8	0	0.830	0.936	1.000
196	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(6)	6769437	18	18	17	5	1	0	3	6	8	0	0.830	0.936	1.000
197	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1)	5547482	11	11	11	3	0	1	1	5	4	0	0.847	0.939	1.000
198	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA2(1), GLB1(5), HEXA(3), LCT(2), MAN2C1(5), MANBA(1), NEU1(1)	10318615	19	18	19	4	1	3	2	10	3	0	0.366	0.939	1.000
199	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), TH(2), TPH1(1)	3765718	5	5	5	2	1	1	1	1	1	0	0.762	0.941	1.000
200	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(1), GRIN1(2), GRIN2A(6), GRIN2B(6), NOS1(9), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), SYT1(1)	16559708	41	36	40	8	7	7	1	19	7	0	0.147	0.942	1.000
201	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(3), CTH(1), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(1), LDHC(3), MPST(2), SULT1B1(2), SULT1C4(1), SULT4A1(1)	8238711	26	26	24	6	2	1	2	9	12	0	0.742	0.943	1.000
202	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	15	AHCY(1), BHMT(2), CTH(1), DNMT3B(2), MARS(2), MARS2(3), MTAP(2), TAT(1)	10261299	14	14	14	2	2	1	3	6	2	0	0.240	0.944	1.000
203	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), ITPKB(2)	3678919	3	3	3	0	1	1	0	0	1	0	0.298	0.944	1.000
204	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(7), CCND2(1), CCNE1(1), CCNH(1), CDC25A(1), CDK2(2), CDKN1A(1), CDKN2A(3), CDKN2C(1), E2F1(1), RB1(2)	10035833	21	21	18	6	0	1	2	5	13	0	0.676	0.945	1.000
205	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(1), PER1(4)	5502413	8	8	7	2	0	0	2	2	4	0	0.688	0.945	1.000
206	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT6(2), ST3GAL3(3)	2932945	5	5	4	2	1	1	0	0	3	0	0.882	0.948	1.000
207	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	35	ACADM(1), ACADS(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), AOX1(7), BCAT1(1), BCKDHA(1), ECHS1(2), EHHADH(5), HADHA(2), HADHB(3), HIBADH(1), IVD(2), MCCC1(2), MCCC2(3), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(3)	23215349	46	45	44	7	3	6	10	16	11	0	0.0731	0.948	1.000
208	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	6	FYN(2), LRP8(4), RELN(5), VLDLR(2)	8547781	13	13	11	2	1	2	0	4	6	0	0.637	0.949	1.000
209	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(3)	8913722	16	16	16	4	3	1	1	10	1	0	0.451	0.950	1.000
210	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), FAH(1), GOT1(3), GOT2(2), HGD(2), MAOA(1), TAT(1), TH(2), TPO(4), TYR(5)	19838487	53	47	51	10	5	4	7	20	17	0	0.244	0.951	1.000
211	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	10	AHCY(1), BHMT(2), CTH(1), DNMT3B(2), MARS(2), MARS2(3)	8048154	11	11	11	2	1	1	2	5	2	0	0.406	0.952	1.000
212	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(2), RB1(2), SP1(2), SP3(2)	4473590	8	8	8	3	0	1	0	2	5	0	0.894	0.954	1.000
213	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1R(1)	3807978	3	3	3	1	0	1	0	1	1	0	0.845	0.955	1.000
214	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT2(2), B3GALT5(1), B3GNT5(1), ST3GAL3(3), ST3GAL4(1)	4537861	9	8	8	4	1	0	1	1	6	0	0.938	0.955	1.000
215	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), IKBKB(1), LTA(1), MAP3K1(5), NFKB1(1), RELA(5), RIPK1(1), TANK(1), TRAF2(1), TRAF3(1)	14638426	20	17	17	2	1	4	0	5	9	1	0.171	0.956	1.000
216	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	24	ABAT(1), ACADM(1), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOC2(3), AOC3(1), CNDP1(3), DPYD(4), DPYS(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), MLYCD(2), SMS(2), UPB1(1)	16820958	34	32	33	6	2	4	10	7	11	0	0.0763	0.957	1.000
217	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), LDLR(1), LPL(2)	3413036	4	4	4	2	0	2	0	1	1	0	0.732	0.958	1.000
218	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	16	ACTR2(1), NCK1(1), NCKAP1(1), NTRK1(5), WASF2(2), WASF3(2)	8915684	12	12	11	2	0	1	1	7	3	0	0.587	0.958	1.000
219	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(2), F5(7), F7(1), FGA(2), FGB(1), FGG(5), PROC(3), PROS1(4), TFPI(1)	10725276	26	25	24	6	1	1	1	10	12	1	0.562	0.959	1.000
220	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(2), NR1H4(2)	3365546	5	5	5	2	0	2	0	2	1	0	0.733	0.959	1.000
221	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(5), DAXX(5), HRAS(1), PAX3(1), PML(2), RARA(4), RB1(2), SIRT1(3), SP100(1), TNFRSF1A(1)	11448480	25	25	25	5	4	1	4	10	6	0	0.298	0.960	1.000
222	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ICAM1(1), ITGA4(2), ITGAL(5), ITGAM(5), ITGB1(4), ITGB2(1), SELE(4), SELP(2)	10666870	26	24	26	6	0	7	4	7	8	0	0.322	0.960	1.000
223	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT3(2), B4GALT5(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1)	5027823	9	9	8	5	1	0	1	1	6	0	0.970	0.963	1.000
224	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(15), CDC25A(1), CDC25B(1), CDC25C(2), CDK2(2), MYT1(2), RB1(2), WEE1(1)	10813436	26	23	26	7	0	3	3	9	11	0	0.644	0.963	1.000
225	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	8	ALDH1B1(1), ALDH2(2), ALDH7A1(1), MIOX(2)	4904897	6	6	6	2	0	2	0	1	3	0	0.747	0.963	1.000
226	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(1), MAP2K3(2), MAP3K1(5), MAPK14(1), MAPK3(1), NFKB1(1), PIK3R1(2), RB1(2), RELA(5), SP1(2)	11540591	22	21	19	4	1	5	0	7	8	1	0.383	0.964	1.000
227	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), DHCR7(2), FDFT1(2), FDPS(1), GGCX(1), IDI1(1), IDI2(1), LSS(2), MVK(1), NSDHL(3), PMVK(1), TM7SF2(1), VKORC1(1)	12617987	20	18	18	2	0	2	1	8	9	0	0.332	0.966	1.000
228	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	11	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), ECHS1(2), EHHADH(5), HADHA(2)	7330936	14	14	13	4	1	4	3	3	3	0	0.457	0.967	1.000
229	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(7), CD38(1), ENPP3(1), NADSYN1(1), NMNAT2(2), NMNAT3(2), NNMT(1), NNT(6), NT5C1B(1), NT5C2(1), NT5M(2), NUDT12(2), QPRT(1)	14178712	28	27	28	5	1	3	4	13	7	0	0.294	0.967	1.000
230	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(15), CDC25A(1), CDC25B(1), CDC25C(2), MYT1(2), WEE1(1)	9173713	22	19	22	5	0	3	2	9	8	0	0.561	0.971	1.000
231	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CD(1), PIK3R1(2), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(2)	19637784	28	27	28	3	5	5	1	14	3	0	0.0266	0.972	1.000
232	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	4	AOC2(3), AOC3(1)	3058553	4	4	4	2	0	0	1	1	2	0	0.789	0.973	1.000
233	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(7), AXIN1(2), BTRC(2), CTNNB1(1), DLL1(1), DVL1(1), FZD1(1), GSK3B(3), NOTCH1(5)	12978526	23	22	20	4	1	3	3	10	6	0	0.269	0.974	1.000
234	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(2), AKT1(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(5), GRB2(2), HRAS(1), MAPK14(1), MAPK3(1), PIK3R1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), RPS6KA5(1), SOS1(5)	16490022	35	34	35	6	4	7	2	16	6	0	0.187	0.974	1.000
235	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL3(1), CD28(1), CXCR4(1), IFNGR1(2), IFNGR2(2), IL12RB1(2), IL12RB2(2), IL18R1(1), IL4(1), IL4R(2), TGFB2(1)	12567307	16	15	16	3	4	1	2	5	4	0	0.314	0.975	1.000
236	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	AGT(1), AKT1(1), CALM2(1), CALR(1), CAMK1(1), CAMK1G(3), CAMK4(1), CREBBP(5), CSNK1A1(2), ELSPBP1(1), F2(2), GATA4(2), GSK3B(3), HRAS(1), MAPK14(1), MAPK3(1), MYH2(9), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NPPA(1), PIK3R1(2), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RAF1(1), RPS6KB1(2), SYT1(1)	31082128	71	58	66	8	7	6	5	22	31	0	0.0111	0.975	1.000
237	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(1), PRKCA(2), RELA(5)	5442041	9	9	6	4	0	3	0	0	5	1	0.927	0.975	1.000
238	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(2), JAK1(4), PTPRU(4), STAT1(3), STAT2(6), TYK2(6)	8016205	27	23	26	7	3	4	3	8	9	0	0.459	0.975	1.000
239	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	22	DHRS2(1), ECHS1(2), EHHADH(5), ESCO1(2), ESCO2(1), FN3K(1), HADHA(2), PNPLA3(2), SH3GLB1(2), YOD1(1)	15974401	19	19	18	2	1	4	3	4	7	0	0.154	0.975	1.000
240	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	8	ALAS1(5), ALAS2(3), FECH(2), PPOX(1), UROD(1)	4606397	12	12	11	5	0	0	3	6	3	0	0.826	0.977	1.000
241	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), CS(2), DLD(2), IDH1(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), PC(3), PCK1(4), SDHA(1), SDHB(1), SUCLA2(1), SUCLG1(5), SUCLG2(2)	13517464	36	32	33	8	2	3	5	15	11	0	0.460	0.977	1.000
242	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD3B1(1)	4396277	5	5	5	2	0	0	1	4	0	0	0.741	0.977	1.000
243	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(5), JAK3(3), MAPK3(1), STAT3(3), TYK2(6)	7595297	22	22	21	9	1	0	4	8	9	0	0.962	0.978	1.000
244	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	9	ADH5(1), CAT(2), EPX(2), MTHFR(1), SHMT1(2), SHMT2(3), TPO(4)	6638497	15	14	15	4	0	3	1	6	5	0	0.663	0.980	1.000
245	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ADCY1(2), CDC25C(2), GNAI1(1), GNAS(5), GNB1(2), HRAS(1), MAPK3(1), MYT1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), SRC(1)	12026772	25	24	25	5	4	2	0	15	4	0	0.336	0.982	1.000
246	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	11	F13A1(1), F2(2), FGA(2), FGB(1), FGG(5), PLAT(4), PLG(5)	8339041	20	19	18	5	1	0	4	7	8	0	0.543	0.983	1.000
247	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), AMDHD1(1), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), DDC(2), FTCD(2), HAL(1), HARS(1), HARS2(1), HNMT(1), LCMT1(1), LCMT2(3), MAOA(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), PRPS1(1), PRPS2(3), UROC1(1)	24875697	44	39	43	5	2	10	7	14	11	0	0.0128	0.983	1.000
248	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	EGF(4), EGFR(9), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(4), JUN(2), MAP3K1(5), MAPK3(1), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2)	23159982	56	50	52	10	6	9	4	17	20	0	0.260	0.983	1.000
249	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(1), TUB(1)	4682284	5	5	5	2	0	0	0	4	1	0	0.848	0.984	1.000
250	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), GOT1(3), GOT2(2), PAH(3), TAT(1), YARS(1)	5743651	11	11	11	4	1	0	2	3	5	0	0.877	0.984	1.000
251	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(5), RPE(1), UGP2(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), XYLB(1)	17938184	39	35	39	7	3	6	6	12	12	0	0.221	0.984	1.000
252	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(1), NFS1(1), THTPA(1)	4262104	4	4	4	2	1	0	1	2	0	0	0.826	0.984	1.000
253	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA2(1), GLB1(5), HEXA(3), LCT(2), MAN2B2(2), MAN2C1(5), MANBA(1), NEU1(1)	12702405	21	19	21	4	1	3	3	11	3	0	0.276	0.985	1.000
254	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15B(2), ALOX5(2), DPEP1(1), GGT1(2), LTA4H(4), PLA2G6(2), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3)	9760650	25	22	23	6	2	4	6	5	7	1	0.410	0.985	1.000
255	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(3), GOT1(3), GOT2(2), GPT(2), GPT2(2), MDH1(1), ME1(1), ME2(2), ME3(2), PGK1(3), RPE(1), TKT(1), TPI1(1)	11637287	25	23	25	6	0	3	5	5	12	0	0.590	0.986	1.000
256	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(1), MAP3K1(5), MAPK3(1), NFKB1(1), NSMAF(3), RAF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	13355727	22	19	19	4	1	4	3	4	9	1	0.260	0.986	1.000
257	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(4), JAK2(5), JAK3(3), PIAS1(4), PIAS3(2), PTPRU(4), SOAT1(4)	8989340	26	22	24	6	1	1	5	9	10	0	0.455	0.987	1.000
258	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD9(1), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), DHRS2(1), ESCO1(2), ESCO2(1), PNPLA3(2), SH3GLB1(2)	16064528	18	17	17	2	1	1	1	9	6	0	0.367	0.987	1.000
259	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ENPP3(1), FLAD1(2), TYR(5)	6339264	12	12	12	4	0	3	0	6	3	0	0.770	0.988	1.000
260	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(6), CLTB(1), COPA(6), GBF1(6), GPLD1(1), KDELR3(2)	10825705	23	22	23	5	1	1	2	11	7	1	0.604	0.988	1.000
261	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), PRKCE(2)	5231754	8	8	8	4	0	0	1	4	3	0	0.939	0.988	1.000
262	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	24	AKT1(1), AKT2(3), AKT3(1), GRB2(2), GSK3A(1), GSK3B(3), IL4R(2), IRS1(4), JAK1(4), JAK3(3), MAP4K1(1), MAPK3(1), PDK1(1), PIK3CD(1), PIK3R1(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(5), SOS2(3), STAT6(4)	21362212	49	42	47	9	6	9	8	16	10	0	0.104	0.988	1.000
263	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	40	AKT1(1), AKT2(3), AKT3(1), BRAF(2), EIF4B(3), FIGF(1), HIF1A(3), MAPK3(1), PGF(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RHEB(3), RICTOR(4), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), TSC1(1), TSC2(5), ULK1(1), ULK2(1), VEGFC(2)	30917206	53	51	49	7	5	8	5	21	12	2	0.0316	0.988	1.000
264	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(1), CDC42(1), DAXX(5), ELK1(1), GRB2(2), HRAS(1), HSPB2(2), MAP3K1(5), MAP3K5(5), MAP3K7(1), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MEF2D(1), MKNK1(2), PLA2G4A(1), RIPK1(1), RPS6KA5(1), SHC1(3), STAT1(3), TGFB2(1), TRADD(2), TRAF2(1)	23765627	45	41	43	7	6	5	2	22	10	0	0.101	0.988	1.000
265	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(2), PRKCA(2), PTK2B(3)	4390874	8	8	7	5	0	3	0	1	4	0	0.959	0.989	1.000
266	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	10	ACTR2(1), CDC42(1)	4272408	2	2	2	1	0	1	0	1	0	0	0.880	0.989	1.000
267	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(1), FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAP3K1(5), MAPK3(1), PIK3R1(2), RAF1(1), SOS1(5), STAT1(3), STAT5A(2), STAT5B(2)	16651053	33	33	32	6	3	5	3	16	6	0	0.234	0.990	1.000
268	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(1), APC(7), AR(1), ASAH1(1), BRAF(2), EGFR(9), GNA15(1), GNAI1(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), KCNJ3(3), MAPK10(1), MAPK14(1), PHKA2(3), PIK3CD(1), PIK3R1(2), PITX2(2), RAF1(1), SRC(1)	33421668	57	44	55	7	8	11	9	20	8	1	0.00420	0.990	1.000
269	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(1), AKT2(3), AKT3(1), BRD4(4), CBL(2), CDC42(1), CDKN2A(3), F2RL2(1), FLOT2(1), GRB2(2), GSK3A(1), GSK3B(3), INPPL1(2), IRS1(4), IRS4(1), LNPEP(2), MAPK3(1), PARD3(5), PDK1(1), PIK3CD(1), PIK3R1(2), PTPN1(1), RAF1(1), RPS6KB1(2), SHC1(3), SORBS1(1), SOS1(5), SOS2(3), YWHAB(1)	34373148	59	52	55	7	5	8	11	16	19	0	0.0162	0.990	1.000
270	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(2), JAK1(4), STAT1(3), STAT3(3), STAT5A(2)	7906947	15	15	14	4	1	0	1	5	8	0	0.882	0.990	1.000
271	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(2), BRAF(2), CREB5(2), DUSP4(1), DUSP9(1), EEF2K(1), EIF4E(1), GRB2(2), MAPK3(1), MKNK1(2), MKNK2(1), MOS(1), NFKB1(1), RAP1A(1), SHC1(3), SOS1(5), SOS2(3), TRAF3(1)	18338607	31	28	31	5	3	5	5	12	5	1	0.203	0.990	1.000
272	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD8A(1), IL3(1), IL4(1)	3292154	3	3	3	2	0	1	1	0	1	0	0.893	0.991	1.000
273	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(2), ITGB1(4), KLRC1(2), KLRC2(3), KLRC3(1), MAPK3(1), PAK1(2), PIK3R1(2), PTK2B(3), PTPN6(3), SYK(1), VAV1(3)	10822179	27	23	26	6	2	5	2	6	12	0	0.497	0.991	1.000
274	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CTH(1), GGT1(2), LCMT1(1), LCMT2(3), MARS(2), MARS2(3), PAPSS1(2), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SCLY(2), SEPHS1(1), SEPHS2(2)	15925758	30	29	30	5	3	2	8	9	8	0	0.200	0.991	1.000
275	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT3(2), B4GALT4(2), FUT6(2), GCNT2(2), ST8SIA1(2)	9677693	16	15	16	4	2	4	3	3	4	0	0.423	0.991	1.000
276	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(3), GOT1(3), GOT2(2), GPT(2), GPT2(2), MDH1(1), ME1(1), ME3(2), PGK1(3), RPE(1), TKT(1), TKTL1(1), TKTL2(2), TPI1(1)	13036866	26	25	26	7	0	2	5	6	13	0	0.736	0.992	1.000
277	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAS1(5), ALAS2(3), CPO(1), FECH(2), GATA1(1), HBB(3), UROD(1)	5212363	16	16	14	5	0	1	3	9	3	0	0.698	0.992	1.000
278	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), FURIN(3), NOTCH1(5)	5218392	9	9	7	3	1	1	0	3	4	0	0.883	0.992	1.000
279	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(1), CAPN2(2), EGF(4), EGFR(9), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), MYL2(1), MYLK(4), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTK2(1), PXN(1), TLN1(6)	21454073	48	43	45	9	8	4	3	17	16	0	0.246	0.993	1.000
280	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), ESCO1(2), ESCO2(1), PNPLA3(2), SH3GLB1(2)	10426338	8	8	8	0	0	1	1	3	3	0	0.267	0.993	1.000
281	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(6), NRG2(2), NRG3(2), PRKCA(2)	6056416	12	12	12	4	1	3	1	5	2	0	0.681	0.993	1.000
282	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	17	AADAC(1), AOC2(3), AOC3(1), DDHD1(2), ESCO1(2), ESCO2(1), PLA1A(3), PNPLA3(2), SH3GLB1(2)	15817911	17	15	17	1	1	1	1	5	9	0	0.148	0.994	1.000
283	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	CAD(9), CANT1(1), DCTD(1), DPYD(4), DPYS(2), DTYMK(1), NT5M(2), POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(9), POLR1B(2), POLR2A(8), POLR2B(4), POLR2I(1), POLRMT(2), RRM1(2), RRM2(1), TK1(1), TK2(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(1)	37085246	73	58	67	10	3	10	10	20	29	1	0.0222	0.994	1.000
284	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(2), CALCRL(1), CD97(4), CRHR1(1), CRHR2(2), ELTD1(2), EMR1(2), EMR2(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(2), LPHN1(2), LPHN2(3), LPHN3(8), SCTR(1), VIPR1(1)	18037113	39	33	39	8	6	5	4	16	8	0	0.164	0.994	1.000
285	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(3), B3GNT7(1), B4GALT3(2), B4GALT4(2), CHST1(2), CHST2(1), CHST4(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1)	7451397	18	17	17	5	1	3	2	3	9	0	0.703	0.994	1.000
286	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AKR1B10(2), ALAS1(5), ALAS2(3), AOC2(3), AOC3(1), BHMT(2), CHDH(2), CHKB(2), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(1), GLDC(3), GNMT(1), MAOA(1), PHGDH(3), PISD(1), PSAT1(1), RDH11(3), SARDH(3), SARS(2), SHMT1(2), SHMT2(3), TARS(5), TARS2(5)	27800539	63	56	59	11	8	9	10	18	18	0	0.0416	0.994	1.000
287	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(1), EIF4A2(3), EIF4B(3), EIF4E(1), EIF4G1(3), EIF4G2(3), EIF4G3(3), MKNK1(2), PDK2(2), PIK3R1(2), PPP2CA(1), RPS6KB1(2), TSC1(1), TSC2(5)	16198912	32	30	30	6	2	5	2	12	10	1	0.284	0.995	1.000
288	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(1), PER1(4), PER2(4), PER3(3)	11025602	15	15	13	3	0	1	4	5	5	0	0.441	0.995	1.000
289	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(3), NAT1(1), NAT2(1), XDH(5)	5170152	13	13	13	5	2	1	2	4	4	0	0.860	0.995	1.000
290	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	28	AADAT(1), AASDH(3), AASDHPPT(2), AASS(4), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), BBOX1(1), DOT1L(2), ECHS1(2), EHHADH(5), EHMT1(3), EHMT2(3), HADHA(2), PLOD1(2), PLOD2(4), SHMT1(2), SHMT2(3), TMLHE(1)	21217727	45	42	43	9	4	9	6	12	14	0	0.179	0.995	1.000
291	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(1), MBTPS1(2), SCAP(1), SREBF1(2), SREBF2(6)	7505675	13	13	13	4	1	3	2	2	5	0	0.681	0.995	1.000
292	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(1), ACP2(1), ACP5(2), ACP6(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP3A7(1), DHRS2(1), PON3(4)	11055410	21	20	20	5	1	5	2	9	4	0	0.402	0.996	1.000
293	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	CFL1(1), CHN1(2), LIMK1(4), MAP3K1(5), MYL2(1), MYLK(4), NCF2(1), PAK1(2), PDGFRA(5), PIK3R1(2), PLD1(2), PPP1R12B(1), RALBP1(1), RPS6KB1(2), TRIO(2), VAV1(3)	21684207	38	37	36	5	1	3	2	16	16	0	0.250	0.996	1.000
294	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	20	ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), DDC(2), EPX(2), GOT1(3), GOT2(2), MAOA(1), PRDX1(1), PRDX5(1), TAT(1), TPO(4)	12582572	26	23	25	5	2	3	6	6	9	0	0.268	0.996	1.000
295	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAD9(1), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AKR1B10(2), ALDH1B1(1), ALDH2(2), ALDH7A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(3), RDH11(3), SLC27A5(2), SOAT1(4), SOAT2(2)	20155645	33	30	30	5	4	2	3	14	10	0	0.186	0.996	1.000
296	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA2B(1), P2RY1(1), P2RY2(1)	3573278	4	4	4	5	0	1	0	2	1	0	0.974	0.996	1.000
297	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(1), EIF2B5(2), EIF2S2(2), EIF4E(1), GSK3B(3), IGF1R(1), INPPL1(2), PDK2(2), PIK3R1(2), PPP2CA(1), RPS6KB1(2)	10903105	19	18	17	4	1	3	0	6	9	0	0.448	0.996	1.000
298	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(4), DDX20(4), E2F1(1), ETS1(1), ETS2(1), FOS(1), HRAS(1), JUN(2), NCOR2(6), RBL2(2), SIN3A(1), SIN3B(1)	16981032	25	23	25	4	2	2	1	10	10	0	0.324	0.996	1.000
299	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(1), BDKRB2(1), CALM2(1), CHRNA1(2), FLT1(7), FLT4(7), KDR(5), NOS3(2), PDE2A(1), PDE3A(3), PDE3B(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKG1(3), PRKG2(2), RYR2(11), SLC7A1(1), SYT1(1), TNNI1(2)	26966845	59	55	59	10	10	10	6	19	14	0	0.0382	0.996	1.000
300	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(7), AXIN1(2), CREBBP(5), CTNNB1(1), DVL1(1), EP300(11), FZD1(1), GSK3B(3), HDAC1(2), LDB1(1), LEF1(1), PITX2(2), TRRAP(8)	21404191	45	39	37	6	1	2	8	17	17	0	0.0964	0.997	1.000
301	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(2), IDH2(5), MDH1(1), OGDH(3), SDHA(1), SUCLA2(1)	6227804	13	12	10	5	0	3	0	5	5	0	0.906	0.997	1.000
302	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	HLA-DRA(1), HLA-DRB1(1), IFNA1(1), IFNB1(2), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(1)	7760287	10	10	10	3	0	3	1	3	3	0	0.683	0.997	1.000
303	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	6	EPX(2), GBA(2), TPO(4)	4506873	8	7	8	3	0	2	0	3	3	0	0.785	0.997	1.000
304	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(1), EGR2(1), EGR3(1), MAP3K1(5), NFATC1(2), NFATC2(5), NFKB1(1), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RELA(5), SYT1(1)	17766085	38	34	32	6	4	5	0	10	18	1	0.250	0.997	1.000
305	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(4), CDKN2A(3), E2F1(1), PIK3R1(2), POLR1A(4), POLR1B(2), POLR1C(2), RB1(2)	10911080	20	20	20	5	0	4	0	8	8	0	0.496	0.997	1.000
306	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), DDC(2), HAL(1), HARS(1), HNMT(1), MAOA(1), PRPS1(1), PRPS2(3)	15182120	28	27	27	6	1	6	6	8	7	0	0.207	0.997	1.000
307	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1), PRKCA(2)	3139352	3	3	3	2	0	1	0	1	1	0	0.914	0.998	1.000
308	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	33	ACTG1(3), ACTG2(1), ACTR2(1), AKT1(1), CDC42(1), CFL1(1), FLNA(4), FLNC(5), FSCN1(3), FSCN3(2), GDI2(1), LIMK1(4), MYH2(9), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), RHO(1), ROCK1(4), ROCK2(2)	29511675	60	50	58	10	4	8	2	16	30	0	0.184	0.998	1.000
309	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(1), AKT1(1), AKT2(3), AKT3(1), CDKN2A(3), GRB2(2), GSK3A(1), GSK3B(3), IARS(4), INPP5D(2), PDK1(1), PPP1R13B(3), RPS6KB1(2), SHC1(3), SOS1(5), SOS2(3), TEC(5), YWHAB(1)	20628865	44	41	42	9	1	8	6	13	16	0	0.276	0.998	1.000
310	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(1), PIK3R1(2), PLCB1(1), PLCG1(2), PRKCA(2), VAV1(3)	7083136	11	11	10	8	1	3	1	1	5	0	0.980	0.998	1.000
311	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BRAF(2), CREB5(2), RAF1(1), SNX13(2), SRC(1)	7645801	9	6	9	3	0	3	1	4	0	1	0.687	0.998	1.000
312	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(2), JAK1(4), JAK2(5), JAK3(3), PIAS3(2), PTPRU(4), SRC(1), STAT3(3)	9856128	24	21	24	9	1	2	3	9	9	0	0.920	0.998	1.000
313	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(2), COPS5(1), EP300(11), HIF1A(3), JUN(2), NOS3(2)	10894418	21	19	18	8	0	0	3	8	10	0	0.863	0.998	1.000
314	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(6), ACO1(4), CLYBL(2), CS(2), DLD(2), IDH1(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), OGDH(3), OGDHL(2), PC(3), PCK1(4), PCK2(1), SDHA(1), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(5), SUCLG2(2)	19614320	51	44	48	11	3	7	5	21	15	0	0.349	0.999	1.000
315	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL4(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(2)	3499094	8	8	8	4	0	2	1	4	1	0	0.742	0.999	1.000
316	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	7	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2)	4556497	5	5	5	4	0	1	1	2	1	0	0.963	0.999	1.000
317	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	7	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2)	4556497	5	5	5	4	0	1	1	2	1	0	0.963	0.999	1.000
318	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(4), DPYS(2), ENPP3(1), PANK1(2), PANK2(4), PANK3(1), PANK4(1), UPB1(1)	9047276	18	17	18	5	1	2	3	7	5	0	0.554	0.999	1.000
319	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CD2(2), CD3E(1), CD3G(2), IL12RB1(2), IL12RB2(2), JAK2(5), STAT4(1), TYK2(6)	9065761	21	21	20	6	2	0	3	9	7	0	0.820	0.999	1.000
320	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(1), CAMK2D(1), CAMK2G(2), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), NFAT5(6), PDE6A(1), PDE6B(3), PDE6C(2), SLC6A13(2)	23627157	37	34	37	6	5	4	7	14	7	0	0.0867	0.999	1.000
321	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(7), CDH1(1), CREBBP(5), EP300(11), MAP3K7(1), MAPK3(1), SKIL(1), TGFB2(1), TGFBR2(1)	16947697	29	27	26	5	2	2	7	10	8	0	0.148	0.999	1.000
322	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1)	4779260	5	5	5	3	0	1	0	3	1	0	0.950	0.999	1.000
323	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(7), ATF2(1), AXIN1(2), BMP10(1), BMP2(1), BMP4(1), BMP5(1), BMP7(3), BMPR2(5), CHRD(3), CTNNB1(1), DVL1(1), FZD1(1), GATA4(2), GSK3B(3), MAP3K7(1), MYL2(1), NPPA(1), NPPB(1), RFC1(4), TGFB2(1), TGFBR2(1), TGFBR3(3)	23282567	47	41	45	7	4	5	4	20	14	0	0.0720	0.999	1.000
324	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	26	ABAT(1), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), AOC2(3), AOC3(1), CNDP1(3), DPYD(4), DPYS(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), MLYCD(2), SMS(2), UPB1(1)	18192725	35	33	34	8	2	4	11	8	10	0	0.178	0.999	1.000
325	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(1), APC(7), AXIN1(2), CTNNB1(1), DVL1(1), FZD1(1), GNAI1(1), GSK3B(3), IRAK1(3), LBP(1), LEF1(1), LY96(1), NFKB1(1), PIK3R1(2), PPP2CA(1), RELA(5), TLR4(2)	18083669	34	34	29	6	1	7	4	10	11	1	0.144	0.999	1.000
326	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), ECH1(2), ESCO1(2), ESCO2(1), FAH(1), GOT1(3), GOT2(2), HGD(2), LCMT1(1), LCMT2(3), MAOA(1), PNPLA3(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SH3GLB1(2), TAT(1), TH(2), TPO(4), TYR(5), TYRP1(1)	37836914	76	64	74	12	6	7	10	29	24	0	0.0864	0.999	1.000
327	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(1), BCAR1(3), GRB2(2), ILK(4), ITGB1(4), MAPK3(1), PDK2(2), PIK3R1(2), PTK2(1), SHC1(3), SOS1(5)	10532557	28	22	26	6	2	5	2	9	10	0	0.598	0.999	1.000
328	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(4), DBH(2), DDC(2), GAD2(1), MAOA(1), PAH(3), SLC18A3(1), TH(2), TPH1(1)	8959575	18	17	16	7	1	3	3	4	7	0	0.873	0.999	1.000
329	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), ATF2(1), CALM2(1), EGFR(9), ELK1(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), MEF2D(1), PAK1(2), PRKCA(2), PTK2(1), PTK2B(3), RAF1(1), SHC1(3), SOS1(5), SRC(1), SYT1(1)	22267611	46	39	44	9	6	11	4	15	10	0	0.207	0.999	1.000
330	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	DPM2(1), HRAS(1), MAPK3(1), NGFR(1), RAF1(1)	4559693	5	5	5	3	1	1	0	3	0	0	0.886	0.999	1.000
331	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(1), PSMD11(3), PSMD13(2), PSMD2(5), PSMD6(1)	10694207	24	21	23	6	1	3	3	6	11	0	0.624	0.999	1.000
332	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BCL2A1(2), CASP1(2), CASP10(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), DAXX(5), DFFB(1), FAS(1), IKBKE(1), LTA(1), NFKB1(1), NGFR(1), NTRK1(5), PTPN13(7), RIPK1(1), TFG(2), TNFRSF1A(1), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2)	28439569	45	40	44	7	3	8	3	22	9	0	0.101	0.999	1.000
333	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR2(2), PDE1A(1), PDE1B(5), PLCB1(1), PLCB2(2)	6946267	11	11	11	9	3	2	0	3	3	0	0.986	0.999	1.000
334	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2E1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2I(3), GTF2IRD1(1), STON1(2), TAF1(5), TAF1L(6), TAF2(5), TAF4(5), TAF4B(5), TAF5(2), TAF5L(2), TAF6(1), TAF7(1), TAF7L(5), TAF9B(1)	23845446	53	47	49	10	4	7	6	18	18	0	0.157	0.999	1.000
335	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP68(2), SRP72(2), SRP9(1)	5035886	6	6	6	3	0	2	0	3	1	0	0.825	0.999	1.000
336	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	59	AKT1(1), AKT2(3), AKT3(1), CDC42(1), CDK2(2), CDKN2A(3), CREB5(2), ERBB4(6), F2RL2(1), GAB1(1), GRB2(2), GSK3A(1), GSK3B(3), INPPL1(2), IRS1(4), IRS4(1), MET(6), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PARD3(5), PDK1(1), PIK3CD(1), PPP1R13B(3), PREX1(6), PTK2(1), PTPN1(1), RPS6KB1(2), SHC1(3), SOS1(5), SOS2(3), TSC1(1), TSC2(5), YWHAB(1)	46110023	90	75	85	15	8	12	8	31	30	1	0.0644	0.999	1.000
337	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	28	AMDHD2(2), CHIA(3), CHIT1(4), CYB5R1(2), CYB5R3(2), GFPT2(1), GNE(1), GNPDA1(1), HEXA(3), HK1(5), MTMR1(1), MTMR2(1), NAGK(2), NANS(2), RENBP(2)	18421982	32	29	32	6	4	4	5	11	8	0	0.103	0.999	1.000
338	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	GBGT1(2), GLA(1), HEXA(3), ST3GAL1(1), ST3GAL4(1), ST8SIA1(2)	6422822	10	10	10	4	0	2	1	5	2	0	0.646	0.999	1.000
339	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(1), APOBEC3B(1), APOBEC4(1)	4821591	9	8	9	6	2	0	2	4	1	0	0.943	0.999	1.000
340	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	ELK1(1), FOS(1), GRB2(2), HRAS(1), INSR(4), IRS1(4), JUN(2), MAPK3(1), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(3), SHC1(3), SOS1(5)	14776831	31	28	29	7	5	8	2	10	6	0	0.329	0.999	1.000
341	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	DPM2(1), EGFR(9), ELK1(1), GNAS(5), GNB1(2), GRB2(2), HRAS(1), IGF1R(1), ITGB1(4), MAPK3(1), MKNK1(2), MKNK2(1), NGFR(1), PDGFRA(5), PPP2CA(1), PTPRR(3), RAF1(1), RPS6KA5(1), SHC1(3), SOS1(5), SRC(1), STAT3(3)	20403140	54	45	52	12	6	10	5	21	12	0	0.313	1.000	1.000
342	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), ATF1(2), CDC42(1), CREB5(2), DUSP10(1), EEF2K(1), EIF4E(1), ELK1(1), IL1R1(1), MAP2K3(2), MAP3K10(3), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(2), MKNK2(1), NFKB1(1), NR2C2(1), TRAF6(2)	21858948	38	36	38	7	2	9	0	21	6	0	0.174	1.000	1.000
343	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	22	ATM(15), BMPR1B(1), CCND2(1), ESR2(2), FSHR(2), MLH1(2), NCOR1(4), NRIP1(4), PGR(2), PRLR(2), PTGER2(1), VDR(1), ZP2(2)	21298073	39	33	39	7	3	7	4	12	13	0	0.177	1.000	1.000
344	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(2), BIRC3(2), CASP10(2), CASP7(1), CASP8(1), CASP9(1), DFFB(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(6)	11618458	22	21	22	5	1	5	2	6	8	0	0.425	1.000	1.000
345	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ALDH1B1(1), ALDH2(2), ALDH7A1(1), CYP2C19(1), DHRS2(1), ECHS1(2), EHHADH(5), ESCO1(2), ESCO2(1), HADHA(2), PNPLA3(2), SH3GLB1(2), YOD1(1)	19182545	23	22	22	4	1	5	3	6	8	0	0.264	1.000	1.000
346	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), NCOA1(2), NCOA2(9), NCOA3(5), NCOR2(6), POLR2A(8), RARA(4), TBP(1)	16358051	39	31	33	9	1	5	5	9	19	0	0.387	1.000	1.000
347	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(1), AKT2(3), AKT3(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(3), PITX2(2), PLD1(2), PLD2(5), PLD3(3)	28922609	48	38	46	7	6	9	8	14	11	0	0.0181	1.000	1.000
348	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(5)	6631308	5	4	5	5	2	0	0	1	2	0	0.972	1.000	1.000
349	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(1), ELK1(1), FOS(1), IKBKB(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(2), MAP3K1(5), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TLR10(2), TLR2(2), TLR4(2), TLR6(1), TLR7(3), TLR9(1), TRAF6(2)	23441123	38	34	34	6	2	8	1	13	13	1	0.179	1.000	1.000
350	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(2), FYN(2), GNAI1(1), GNB1(2), GRB2(2), HRAS(1), JAK2(5), MAPK14(1), MAPK3(1), MAPT(3), MYLK(4), PLCG1(2), PRKCA(2), PTK2B(3), RAF1(1), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2), SYT1(1)	27480771	55	48	53	10	4	9	6	21	15	0	0.187	1.000	1.000
351	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(1), SNCAIP(2), UBE2E2(1)	4184639	5	5	5	3	0	3	1	0	1	0	0.829	1.000	1.000
352	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLB(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLG(4), POLG2(4), POLH(4), POLI(3), POLK(3), POLL(2), POLM(3), POLQ(9), PRIM1(2), PRIM2(2), REV1(2), REV3L(12), RFC5(1)	27198763	65	52	59	12	4	4	3	32	22	0	0.341	1.000	1.000
353	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), GREB1(11), HSPB2(2), MTA1(1), MTA3(2)	6796750	17	16	15	6	0	1	2	10	4	0	0.895	1.000	1.000
354	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(5), CD19(1), CD1A(1), CD1B(1), CD1C(1), CD1D(2), CD1E(2), CD2(2), CD22(4), CD33(1), CD34(2), CD38(1), CD3E(1), CD3G(2), CD44(2), CD55(1), CD8A(1), CR1(7), CR2(2), CSF1R(4), CSF2RA(2), CSF3R(2), DNTT(4), FLT3(6), HLA-DRA(1), HLA-DRB1(1), IL11RA(1), IL1B(1), IL1R1(1), IL1R2(4), IL2RA(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL9R(2), ITGA1(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGAM(5), ITGB3(1), KITLG(2), MME(5), MS4A1(1), TFRC(2), TPO(4)	52645767	115	83	107	21	6	10	13	38	48	0	0.224	1.000	1.000
355	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(1), ADSL(1), AGXT(1), ASL(4), ASNS(1), ASPA(1), CAD(9), CRAT(1), DARS(1), GAD2(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), PC(3)	16996699	35	31	31	7	1	3	9	4	17	1	0.420	1.000	1.000
356	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10060370	18	17	18	6	0	2	4	6	6	0	0.774	1.000	1.000
357	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10060370	18	17	18	6	0	2	4	6	6	0	0.774	1.000	1.000
358	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10060370	18	17	18	6	0	2	4	6	6	0	0.774	1.000	1.000
359	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), ATF2(1), CDC42(1), DLD(2), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), IL1R1(1), JUN(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K11(1), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAP3K9(3), MAPK10(1), MAPK7(1), MAPK9(2), NFATC3(5), NR2C2(1), PAPPA(1), SHC1(3), TRAF6(2), ZAK(3)	32050460	66	60	63	11	5	8	8	27	18	0	0.0951	1.000	1.000
360	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(5), CD44(2), IL1B(1), IL6R(2), SPN(1), TGFB2(1), TNFRSF1A(1)	8490160	13	13	11	4	2	4	0	1	6	0	0.691	1.000	1.000
361	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(1), AKT2(3), AKT3(1), BCL10(1), CARD11(8), CBL(2), CBLB(2), CBLC(1), CD28(1), CD3E(1), CD3G(2), CD8A(1), CDC42(1), CHUK(1), CTLA4(1), FOS(1), FYN(2), GRAP2(1), GRB2(2), HRAS(1), ICOS(2), IKBKB(1), IL4(1), ITK(1), JUN(2), KRAS(1), LCP2(1), MALT1(1), NCK1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIB(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDK1(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCQ(4), PTPN6(3), PTPRC(6), RASGRP1(2), SOS1(5), SOS2(3), TEC(5), VAV1(3), VAV2(4)	63294741	138	102	132	21	7	19	16	58	38	0	0.0204	1.000	1.000
362	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(5), IMPA2(3)	7466458	8	7	8	6	3	0	0	2	3	0	0.970	1.000	1.000
363	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(5), EP300(11), MAPK3(1), PELP1(1), SRC(1)	9572843	19	16	16	7	2	1	4	5	7	0	0.789	1.000	1.000
364	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(1), B4GALT3(2), B4GALT5(1), DPAGT1(5), DPM1(1), MAN1A1(2), MGAT4A(3), MGAT4B(1), MGAT5(3), RPN1(2), RPN2(1)	12592340	24	24	24	7	0	6	0	9	9	0	0.645	1.000	1.000
365	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), GLB1(5), HEXA(3), LCT(2), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	10442846	23	21	23	6	1	4	2	10	6	0	0.399	1.000	1.000
366	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), FUCA2(1), GALNS(2), GBA(2), GLB1(5), GNS(1), GUSB(5), HEXA(3), HGSNAT(1), HPSE(1), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), MAN2B2(2), MAN2C1(5), MANBA(1), NAGLU(2), NEU1(1), SPAM1(6)	21861110	50	42	50	10	5	8	6	21	10	0	0.108	1.000	1.000
367	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(1), CCNE1(1), CDK2(2), CDKN1A(1), E2F1(1), HRAS(1), MAPK3(1), NFKB1(1), PAK1(2), PIK3R1(2), RAF1(1), RB1(2), RELA(5)	11431055	21	19	18	5	1	4	1	5	9	1	0.620	1.000	1.000
368	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	64	A2M(5), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(3), C2(4), C3(6), C3AR1(1), C4BPA(3), C4BPB(2), C5(5), C5AR1(2), C6(1), C7(3), C8A(1), C8B(1), C8G(1), CD55(1), CFB(2), CFH(4), CFI(1), CR1(7), CR2(2), F11(1), F12(3), F13A1(1), F13B(2), F2(2), F5(7), F7(1), F8(5), F9(2), FGA(2), FGB(1), FGG(5), KLKB1(2), KNG1(2), MASP1(2), MASP2(1), MBL2(1), PLAT(4), PLAUR(2), PLG(5), PROC(3), PROS1(4), SERPINA1(2), SERPIND1(2), SERPINF2(2), SERPING1(2), TFPI(1), VWF(11)	57372434	137	107	132	25	13	17	15	57	32	3	0.0186	1.000	1.000
369	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GNE(1), GNPDA1(1), HEXA(3), HK1(5), RENBP(2)	11123051	14	13	14	5	2	0	2	4	6	0	0.743	1.000	1.000
370	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	14	B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST12(2), CHST14(1), CHST7(1), DSE(1), XYLT1(2), XYLT2(2)	6962785	14	14	14	5	2	5	0	4	3	0	0.549	1.000	1.000
371	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(1), EDNRB(3), EGF(4), EGFR(9), FOS(1), HRAS(1), JUN(2), NFKB1(1), PLCG1(2), PRKCA(2), RELA(5)	13362042	33	29	27	8	4	4	3	10	11	1	0.604	1.000	1.000
372	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(4), JUN(2), MAP3K1(5), MAPK3(1), PDGFRA(5), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2)	21480000	48	45	46	10	4	8	3	17	16	0	0.407	1.000	1.000
373	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	26	ABAT(1), ACADS(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), SDHB(1)	16328016	26	25	24	6	4	5	6	5	6	0	0.229	1.000	1.000
374	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	11	FOS(1), JUN(2), KEAP1(2), MAPK14(1), PRKCA(2)	4794121	8	8	8	6	1	1	2	3	1	0	0.962	1.000	1.000
375	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	10593136	18	17	18	6	0	2	4	6	6	0	0.771	1.000	1.000
376	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(4), ATM(15), ATR(7), CCNA1(7), CCNE1(1), CDC25A(1), CDK2(2), CDKN1A(1), CDKN2A(3), E2F1(1), GSK3B(3), HDAC1(2), RB1(2), SKP2(1), TGFB2(1)	18788624	51	46	46	11	0	7	4	13	27	0	0.392	1.000	1.000
377	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(5), CD2(2), CD33(1), IFNA1(1), IFNB1(2), IL3(1), IL4(1), ITGAX(3), TLR2(2), TLR4(2), TLR7(3), TLR9(1)	11884722	24	23	23	9	2	4	4	7	7	0	0.810	1.000	1.000
378	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	22	ALDOA(1), ALDOB(3), G6PD(2), PFKM(3), PFKP(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RPE(1), TALDO1(1), TKT(1)	12207925	20	20	20	8	1	4	4	4	7	0	0.820	1.000	1.000
379	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(5), EP300(11), IKBKB(1), IL1B(1), MAP2K3(2), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TGFBR2(1), TLR2(2)	19371642	32	28	26	5	1	3	4	10	13	1	0.288	1.000	1.000
380	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM2(1), CD3E(1), CD3G(2), ELK1(1), FOS(1), FYN(2), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), PIK3R1(2), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), PTPN7(1), RAF1(1), RASA1(3), RELA(5), SHC1(3), SOS1(5), SYT1(1), VAV1(3)	29309427	68	60	62	14	6	14	5	19	23	1	0.268	1.000	1.000
381	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(2), CASP7(1), CASP8(1), CFLAR(1), DAXX(5), DFFB(1), FAF1(1), JUN(2), LMNB1(3), MAP3K1(5), MAP3K7(1), PAK1(2), PAK2(2), PRKDC(10), PTPN13(7), RB1(2), RIPK2(2), SPTAN1(6)	28042411	55	47	55	9	3	6	6	21	19	0	0.0927	1.000	1.000
382	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(1), IL1R1(1), IRAK1(3), MAP3K1(5), MAP3K7(1), NFKB1(1), RELA(5), RIPK1(1), TLR4(2), TNFRSF1A(1), TRADD(2), TRAF6(2)	15645914	26	23	23	6	1	7	2	4	11	1	0.457	1.000	1.000
383	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(1), AKT1(1), AKT2(3), AKT3(1), ARHGAP1(1), ARHGEF11(5), CDC42(1), CFL1(1), GDI2(1), INPPL1(2), ITPR1(4), ITPR2(9), ITPR3(4), LIMK1(4), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDK1(1), PIK3CD(1), PIK3CG(3), PIK3R1(2), PITX2(2), PPP1R13B(3), RACGAP1(1), RHO(1), ROCK1(4), ROCK2(2), SAG(5)	43371158	80	64	77	12	5	15	9	24	27	0	0.0177	1.000	1.000
384	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(7), ASAH1(1), CERK(5), CREB5(2), EPHB2(2), FOS(1), ITPKB(2), JUN(2), MAP2K7(1), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2)	17965013	31	28	28	6	5	4	3	11	8	0	0.262	1.000	1.000
385	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(5), G6PD(2), GCLC(1), GGT1(2), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), IDH1(2), IDH2(5)	11898082	21	18	18	8	0	2	5	5	9	0	0.928	1.000	1.000
386	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(1), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(2), PIGO(4), PIGP(1), PIGQ(3), PIGT(6), PIGU(1), PIGV(1), PIGZ(3)	15947146	32	30	28	8	1	4	4	12	10	1	0.643	1.000	1.000
387	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1)	5903596	6	6	6	3	0	0	1	5	0	0	0.813	1.000	1.000
388	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1)	5903596	6	6	6	3	0	0	1	5	0	0	0.813	1.000	1.000
389	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(1), DPM2(1), GRB2(2), HRAS(1), NTRK1(5), PIK3R1(2), PLCG1(2), PRKCA(2), SHC1(3), SOS1(5)	8657332	24	23	22	8	1	6	1	10	6	0	0.831	1.000	1.000
390	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IL15(1), IL16(4), IL3(1), IL4(1), LTA(1)	6394068	11	11	11	5	0	4	1	5	1	0	0.786	1.000	1.000
391	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(2), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GPHN(1), SRC(1), UBQLN1(2)	7898767	11	11	11	5	0	3	2	4	2	0	0.838	1.000	1.000
392	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(2), BID(1), BIK(1), BIRC2(2), BIRC3(2), CASP7(1), CASP8(1), CASP9(1), DFFB(1)	8930987	12	12	12	5	0	2	1	5	4	0	0.815	1.000	1.000
393	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	24	ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), DDC(2), EPX(2), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), MAOA(1), PNPLA3(2), SH3GLB1(2), TAT(1), TPO(4)	20529847	31	29	30	5	2	4	5	8	12	0	0.202	1.000	1.000
394	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	30	ALOX12(2), ALOX5(2), CBR1(2), CYP4F2(2), EPX(2), GGT1(2), LTA4H(4), PLA2G4A(1), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3), TPO(4)	17053019	35	32	33	8	3	6	7	9	9	1	0.318	1.000	1.000
395	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(1), DPYD(4), DPYS(2), ENPP3(1), ILVBL(2), PANK1(2), PANK2(4), PANK3(1), PANK4(1), UPB1(1), VNN1(1)	11219940	21	20	21	8	1	3	3	8	6	0	0.798	1.000	1.000
396	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK3(1), NFKB1(1), PLCB1(1), PRKCA(2), RAF1(1), RELA(5)	9892034	17	17	14	6	4	3	0	4	5	1	0.755	1.000	1.000
397	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(1), BRAF(2), CHUK(1), DAXX(5), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(1), JUN(2), MAP2K3(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K11(1), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP3K9(3), MAP4K1(1), MAP4K3(4), MAP4K4(2), MAP4K5(4), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK7(1), MAPK9(2), MAPKAPK2(1), MEF2D(1), MKNK1(2), MKNK2(1), NFKB1(1), PAK1(2), PAK2(2), RAF1(1), RELA(5), RIPK1(1), RPS6KA4(1), RPS6KA5(1), RPS6KB1(2), RPS6KB2(2), SHC1(3), SP1(2), STAT1(3), TGFB2(1), TRADD(2), TRAF2(1)	61353582	111	82	106	16	13	13	7	40	36	2	0.0201	1.000	1.000
398	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(2), ILVBL(2), LARS(3), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1), VARS(2), VARS2(2)	11227977	22	18	22	8	0	6	2	8	6	0	0.713	1.000	1.000
399	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(6), ALG11(3), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG5(1), ALG6(2), ALG8(1), B4GALT3(2), DOLPP1(2), DPAGT1(5), DPM1(1), MAN1A1(2), MAN1A2(1), MAN2A1(3), MGAT4A(3), MGAT4B(1), MGAT5(3), MGAT5B(2), RPN1(2), RPN2(1), STT3B(3)	27562098	57	47	56	11	0	12	2	21	22	0	0.250	1.000	1.000
400	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(4), ARHGEF1(2), GNA12(1), GNA13(4), GNB1(2), MYL2(1), MYLK(4), PLCB1(1), PPP1R12B(1), PRKCA(2), ROCK1(4)	13493006	26	26	26	8	1	2	0	16	7	0	0.781	1.000	1.000
401	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(1), GRB2(2), HRAS(1), MAPK3(1), MAPK7(1), MEF2D(1), NTRK1(5), PIK3R1(2), PLCG1(2), SHC1(3)	9969645	19	17	17	5	3	3	0	8	5	0	0.639	1.000	1.000
402	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(2), BCL10(1), BID(1), CASP9(1)	6958800	5	5	5	3	0	0	0	3	2	0	0.932	1.000	1.000
403	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(1), CAT(2), GHR(1), HRAS(1), IGF1R(1), PIK3R1(2), SHC1(3)	7101553	11	10	11	5	2	2	1	4	2	0	0.850	1.000	1.000
404	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	14	ACADM(1), ACADS(3), ACSL1(2), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(5), HADHA(2), PECR(1), SCP2(2)	10119412	19	18	17	6	2	4	6	4	3	0	0.378	1.000	1.000
405	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACP6(1), ENPP3(1), FLAD1(2), MTMR1(1), MTMR2(1), TYR(5)	9877713	15	15	15	5	0	3	0	9	3	0	0.794	1.000	1.000
406	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(1), CD3G(2), ETV5(1), IL12RB1(2), IL12RB2(2), IL18R1(1), JAK2(5), JUN(2), MAPK14(1), STAT4(1), TYK2(6)	12283508	24	24	23	7	2	0	3	12	7	0	0.830	1.000	1.000
407	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(2), AARS2(2), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), ASL(4), ASNS(1), ASPA(1), ASS1(2), CAD(9), CRAT(1), DARS(1), DARS2(1), DLAT(2), DLD(2), GAD2(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), NARS2(4), PC(3), PDHA1(1), PDHA2(2), PDHB(1)	24292576	53	43	49	10	2	5	11	13	21	1	0.235	1.000	1.000
408	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	32	ABAT(1), ACACA(6), ACACB(4), ACADM(1), ACSS1(2), ACSS2(7), ALDH1B1(1), ALDH2(2), ALDH7A1(1), ECHS1(2), EHHADH(5), HADHA(2), LDHAL6B(1), LDHB(1), LDHC(3), MCEE(1), MLYCD(2), MUT(2), PCCA(1), PCCB(3), SUCLA2(1), SUCLG1(5), SUCLG2(2)	25651783	56	47	53	12	3	7	15	13	17	1	0.199	1.000	1.000
409	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(2), ARG1(1), ASL(4), CPS1(4), GATM(1), OAT(1), ODC1(2), OTC(1), PYCR1(1), SMS(2)	11356087	19	19	19	6	0	2	4	8	5	0	0.765	1.000	1.000
410	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(5), G6PD(2), GCLC(1), GGT1(2), GPX6(1), GSR(1), GSS(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTM1(1), IDH1(2), IDH2(5), OPLAH(2), TXNDC12(1)	14138763	27	23	24	7	0	2	6	8	11	0	0.724	1.000	1.000
411	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(2), CPEB1(3), EGFR(9), ERBB2(4), ERBB4(6), ETS1(1), ETS2(1), ETV6(2), FMN2(5), GRB2(2), KRAS(1), MAPK3(1), NOTCH1(5), NOTCH2(9), NOTCH3(8), NOTCH4(5), PIWIL1(2), PIWIL2(2), PIWIL3(3), PIWIL4(1), RAF1(1), SOS1(5), SOS2(3), SPIRE1(1), SPIRE2(1)	32271932	83	69	80	17	12	7	10	33	19	2	0.221	1.000	1.000
412	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(15), ATR(7), BRCA1(5), CDC25A(1), CDC25B(1), CDC25C(2), CDKN1A(1), CHEK2(1), EP300(11), MYT1(2), PRKDC(10), WEE1(1)	26961333	57	48	54	10	0	7	7	25	18	0	0.153	1.000	1.000
413	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(7), CALM2(1), CAPN2(2), EP300(11), HDAC1(2), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(2), PPP3CC(3), PRKCA(2), SYT1(1)	15555640	39	32	34	10	4	4	4	14	13	0	0.485	1.000	1.000
414	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(1), ALDOB(3), G6PD(2), PFKL(1), PFKM(3), PFKP(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RPE(1), TALDO1(1), TKT(1), TKTL1(1), TKTL2(2)	14866246	24	24	24	8	1	5	4	6	8	0	0.709	1.000	1.000
415	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CD28(1), CSK(3), CTLA4(1), DTYMK(1), EPHB2(2), FBXW7(2), GRAP2(1), GRB2(2), ITK(1), ITPKB(2), LCP2(1), NCK1(1), NFAT5(6), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PLCG1(2), PTPRC(6), RAF1(1), RASGRP1(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(5), SOS2(3), VAV1(3)	36156246	69	57	68	12	6	9	7	27	20	0	0.126	1.000	1.000
416	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), BAAT(1), CEL(1), CYP27A1(1), HADHB(3), SOAT2(2)	14653567	21	20	20	6	2	2	2	10	5	0	0.743	1.000	1.000
417	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(5), ACE2(2), AGT(1), AGTR1(2), ANPEP(5), CMA1(1), CTSA(1), ENPEP(2), LNPEP(2), MAS1(1), MME(5), REN(1), THOP1(1)	13831036	29	26	25	8	1	4	8	7	9	0	0.665	1.000	1.000
418	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	44	ACADM(1), ACADS(3), ACOX1(1), ACOX3(2), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1B1(1), ALDH2(2), ALDH7A1(1), CPT1A(1), CPT1C(4), CPT2(1), CYP4A11(4), ECHS1(2), EHHADH(5), HADH(1), HADHA(2), HADHB(3)	30119922	51	48	46	10	5	6	11	15	14	0	0.124	1.000	1.000
419	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM2(1), ELK1(1), FOS(1), GNAI1(1), GNAS(5), GNB1(2), HRAS(1), JUN(2), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), RAF1(1), SYT1(1)	21997311	51	44	48	12	7	6	2	19	17	0	0.465	1.000	1.000
420	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(2), AKT1(1), CSF2RB(1), IGF1R(1), IL3(1), KITLG(2), PIK3R1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2)	12738720	18	18	18	5	5	2	0	7	4	0	0.414	1.000	1.000
421	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CXCR4(1), FOS(1), JUN(2), MAPK14(1), PLCG1(2), PRKCA(2), PTK2B(3), SYT1(1)	8980806	15	14	14	6	2	4	1	4	4	0	0.819	1.000	1.000
422	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(1), CAD(9), CPS1(4), EPRS(2), GAD2(1), GCLC(1), GLS(3), GLS2(4), GOT1(3), GOT2(2), GPT(2), GPT2(2), GSS(1), NADSYN1(1), QARS(1)	21914311	38	33	34	7	2	4	7	11	13	1	0.356	1.000	1.000
423	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(2), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2)	6802671	10	10	10	5	2	1	2	4	1	0	0.775	1.000	1.000
424	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(1), DAXX(5), EGF(4), EGFR(9), ETS1(1), ETS2(1), FOS(1), HRAS(1), IKBKB(1), JUN(2), MAP2K3(2), MAP2K7(1), MAP3K1(5), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(1), NFKB1(1), PPP2CA(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), RAF1(1), RELA(5), RIPK1(1), SP1(2), TNFRSF1A(1), TRAF2(1)	31927150	72	57	66	15	9	7	2	27	26	1	0.387	1.000	1.000
425	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(2), ARF1(1), EEA1(6), GSK3A(1), GSK3B(3), PFKL(1), PFKM(3), PFKP(2), PLCG1(2), PRKCE(2), PRKCZ(1), RAB5A(1), RPS6KB1(2), VAV2(4)	16531177	32	28	29	8	2	5	4	9	12	0	0.511	1.000	1.000
426	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10A(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL27(1), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL32(1), RPL34(1), RPL36AL(1), RPL38(1), RPL3L(2), RPL7(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS9(1)	14457472	36	34	36	9	2	3	6	18	7	0	0.494	1.000	1.000
427	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	15	ABCC2(1), BCHE(2), CES2(2), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3)	12526137	17	15	17	5	1	2	3	5	6	0	0.691	1.000	1.000
428	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(2), CALR(1), CANX(1), CD74(1), CD8A(1), CIITA(3), CTSB(3), CTSS(1), HLA-B(1), HLA-C(2), HLA-DPA1(1), HLA-DPB1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(1), HLA-E(2), HLA-F(1), HSP90AA1(4), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), KIR2DL3(1), KIR3DL1(3), KIR3DL3(1), KLRC1(2), KLRC2(3), KLRC3(1), LTA(1), NFYC(2), RFX5(2), RFXAP(1), TAP2(1)	26477226	62	53	61	14	2	7	7	28	18	0	0.578	1.000	1.000
429	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(6), ACACB(4), FASN(3), OLAH(1), OXSM(1)	10057712	15	15	15	5	2	0	4	6	3	0	0.683	1.000	1.000
430	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA14(3), CA5B(1), CA7(1), CA9(1), CPS1(4), CTH(1), GLS(3), GLS2(4), HAL(1)	12473657	20	19	20	6	1	2	2	14	1	0	0.667	1.000	1.000
431	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(4), ANAPC2(1), ANAPC4(5), ANAPC5(1), ANAPC7(2), BTRC(2), CDC16(3), CDC20(1), CDC23(2), CDC27(1), CUL1(3), CUL2(1), CUL3(6), FBXW11(1), FBXW7(2), FZR1(3), ITCH(1), SKP2(1), SMURF1(1), SMURF2(2), TCEB2(1), UBA1(1), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), WWP2(3)	26524349	54	54	50	11	2	6	5	20	20	1	0.352	1.000	1.000
432	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(1), CHRNB1(2), MUSK(1), PIK3R1(2), PTK2(1), PTK2B(3), SRC(1), TERT(5)	9240306	16	14	16	5	2	7	0	4	3	0	0.606	1.000	1.000
433	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	44	AADAC(1), ABAT(1), ACADS(3), ACSM1(1), AKR1B10(2), ALDH1B1(1), ALDH2(2), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(5), GAD2(1), HADH(1), HADHA(2), HMGCS1(1), HMGCS2(1), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), PLA1A(3), RDH11(3)	26063556	43	38	41	9	6	7	6	12	12	0	0.194	1.000	1.000
434	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PLCG1(2), PTPN6(3), RAF1(1), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2)	13912285	31	29	29	8	3	4	3	12	9	0	0.640	1.000	1.000
435	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAS1(5), ALAS2(3), BLVRA(1), COX10(2), COX15(1), CP(1), EPRS(2), FECH(2), FTMT(3), GUSB(5), HCCS(1), HMOX1(2), MMAB(1), PPOX(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), UROD(1)	27310462	59	52	57	13	5	8	8	24	14	0	0.253	1.000	1.000
436	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	30	ABAT(1), ACACA(6), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), ECHS1(2), EHHADH(5), HADHA(2), LDHB(1), LDHC(3), MCEE(1), MLYCD(2), MUT(2), PCCA(1), PCCB(3), SUCLA2(1), SUCLG1(5), SUCLG2(2)	21319628	43	40	41	10	3	5	11	12	12	0	0.259	1.000	1.000
437	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), MAPK8IP3(1), PAPPA(1), SHC1(3), SOS1(5), SYK(1), VAV1(3), VAV2(4)	19613783	32	28	32	8	4	6	3	13	6	0	0.356	1.000	1.000
438	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(1), AGTR1(2), CMA1(1), COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(7), COL4A6(4), REN(1)	16834151	27	25	27	9	3	10	3	7	4	0	0.534	1.000	1.000
439	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	CASP1(2), CASP7(1), CASP8(1), GAPDH(2), INSR(4), ITCH(1), MAGI1(3), MAGI2(4), RERE(4), WWP2(3)	14223023	25	23	21	7	5	2	3	8	7	0	0.715	1.000	1.000
440	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(1), AKT2(3), AKT3(1), GRB2(2), IARS(4), IL13RA1(1), IL4(1), IL4R(2), INPP5D(2), JAK1(4), JAK2(5), JAK3(3), PPP1R13B(3), RPS6KB1(2), SHC1(3), SOS1(5), SOS2(3), SRC(1), STAT6(4), TYK2(6)	22441811	56	47	55	13	2	9	11	19	15	0	0.386	1.000	1.000
441	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(2), ARHGEF1(2), F2(2), GNA12(1), GNA13(4), GNAI1(1), GNB1(2), MAP3K7(1), PIK3R1(2), PLCB1(1), PPP1R12B(1), PRKCA(2), PTK2B(3), ROCK1(4)	15370591	28	27	28	8	2	4	1	14	7	0	0.600	1.000	1.000
442	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR1(1), SNAP23(1), STX10(1), STX11(1), STX16(1), STX19(1), STX2(1), STX4(1), STX7(1), STX8(1), TSNARE1(2), VAMP2(1)	11051827	13	13	13	8	2	2	1	5	3	0	0.926	1.000	1.000
443	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(5), EP300(11), FYN(2), JAK1(4), JAK3(3), PIK3R1(2), PTK2B(3), STAT5A(2), STAT5B(2)	16897303	34	30	30	9	1	4	7	10	12	0	0.565	1.000	1.000
444	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	CAD(9), CASP10(2), CASP8(1), CSNK1A1(2), DAXX(5), DEDD(1), EGFR(9), EPHB2(2), FAF1(1), FAIM2(1), MAP2K7(1), MAP3K1(5), MAP3K5(5), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(6), NFAT5(6), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PTPN13(7), RALBP1(1), RIPK1(1), ROCK1(4), TPX2(1), TRAF2(1)	47000460	83	70	76	14	9	6	6	37	24	1	0.111	1.000	1.000
445	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	25	BLVRA(1), CP(1), EPRS(2), FECH(2), GUSB(5), HCCS(1), HMOX1(2), PPOX(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2), UROD(1)	17598066	31	29	31	9	4	4	4	10	9	0	0.585	1.000	1.000
446	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	DPM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAPK3(1), NGFR(1), PIK3R1(2), PLCG1(2), RAF1(1), SHC1(3), SOS1(5)	10787517	23	22	22	7	3	5	1	10	4	0	0.739	1.000	1.000
447	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), ARHGDIB(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), DFFB(1), LMNB1(3), PRF1(1)	12493614	20	19	20	7	0	6	2	7	5	0	0.692	1.000	1.000
448	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	29	ACTR2(1), ARHGAP1(1), ARHGAP5(4), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(1), CFL1(1), DIAPH1(3), GSN(2), LIMK1(4), MYL2(1), MYLK(4), OPHN1(2), PIP5K1A(2), PPP1R12B(1), ROCK1(4), SRC(1), TLN1(6), VCL(2)	29221627	49	45	46	9	2	5	2	18	22	0	0.400	1.000	1.000
449	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), ERCC3(1), GTF2E1(1), GTF2E2(2), GTF2F2(1), GTF2H1(2), GTF2H2(1), ILK(4), MNAT1(1), POLR1A(4), POLR1B(2), POLR2A(8), POLR2B(4), POLR2I(1), POLR3B(3), POLR3H(1), POLR3K(1), TAF5(2), TAF6(1), TAF7(1), TBP(1)	22995703	43	39	41	9	1	6	5	13	18	0	0.325	1.000	1.000
450	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(1), CABIN1(7), CALM2(1), CAMK1(1), CAMK1G(3), IGF1R(1), INSR(4), MAPK14(1), MAPK7(1), MEF2D(1), NFATC1(2), NFATC2(5), PIK3R1(2), PPP3CA(2), PPP3CC(3), SYT1(1)	20750278	36	32	31	8	4	5	2	10	15	0	0.399	1.000	1.000
451	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(1), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SMPD2(2), SPTLC1(1)	15163689	24	22	24	8	1	5	4	8	6	0	0.678	1.000	1.000
452	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(1), CAD(9), CPS1(4), EPRS(2), GAD2(1), GCLC(1), GFPT2(1), GLS(3), GLS2(4), GOT1(3), GOT2(2), GPT(2), GPT2(2), GSR(1), GSS(1), NADSYN1(1), NAGK(2), QARS(1)	26048357	42	36	38	8	3	4	9	12	13	1	0.301	1.000	1.000
453	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(1), CAMK1G(3), ELK1(1), FPR1(2), GNA15(1), GNB1(2), HRAS(1), MAP2K3(2), MAP3K1(5), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), PAK1(2), PIK3C2G(2), PLCB1(1), PPP3CA(2), PPP3CC(3), RAF1(1), RELA(5), SYT1(1)	25044200	56	45	50	13	5	7	3	17	23	1	0.506	1.000	1.000
454	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT2(3), AKT3(1), ANKRD6(2), APC(7), AXIN1(2), AXIN2(1), CSNK1A1(2), CTNNB1(1), DACT1(1), DVL1(1), FSTL1(2), GSK3A(1), GSK3B(3), LRP1(11), MVP(4), NKD1(2), NKD2(1), PTPRA(3), SENP2(1), WIF1(4)	26105870	54	46	50	12	3	10	7	16	18	0	0.223	1.000	1.000
455	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(1), ARSE(1), CYP11B2(2), HSD17B2(1), HSD17B8(1), HSD3B1(1), SULT2A1(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2)	17731963	23	21	23	6	1	3	3	7	9	0	0.531	1.000	1.000
456	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(1), GRB2(2), HRAS(1), IGF1R(1), IRS1(4), MAPK3(1), PIK3R1(2), RAF1(1), SHC1(3), SOS1(5)	10615957	21	19	21	7	5	5	1	8	2	0	0.572	1.000	1.000
457	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AGK(5), AKR1B1(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), CEL(1), DAK(2), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), GK(1), GK2(1), GLA(1), GLB1(5), GPAM(2), LCT(2), LIPC(1), LIPF(1), LPL(2), PNLIP(4), PNPLA3(2), PPAP2B(1), PPAP2C(2)	37879020	65	53	64	13	6	10	8	22	19	0	0.121	1.000	1.000
458	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ADCY4(2), ADCY6(1), ADCY8(8), CACNA1A(5), CACNA1B(4), GNAS(5), GNB1(2), GNB3(2), GNG3(1), GRM4(3), ITPR3(4), KCNB1(1), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(2), PRKACG(2), SCNN1A(2), SCNN1B(2), SCNN1G(2), TAS1R2(3), TAS1R3(2), TAS2R13(1), TAS2R38(2), TAS2R39(1), TAS2R42(1), TAS2R43(2), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(1)	36438522	71	61	70	15	14	6	6	26	19	0	0.208	1.000	1.000
459	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX5(2), CYP1A2(3), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2J2(3), CYP3A7(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), RDH11(3)	15699422	22	22	22	8	3	2	3	9	5	0	0.688	1.000	1.000
460	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(2), BID(1), BIRC2(2), BIRC3(2), CASP10(2), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), DFFB(1), GAS2(2), NFKB1(1), RELA(5), RIPK1(1), SPTAN1(6), TRADD(2), TRAF2(1)	21450769	33	28	30	8	0	5	4	11	12	1	0.529	1.000	1.000
461	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(1), CABIN1(7), CALM2(1), CAMK2B(1), CAMK4(1), CD3E(1), CD3G(2), CDKN1A(1), CNR1(1), CREBBP(5), CSNK2B(1), CTLA4(1), EGR2(1), EGR3(1), EP300(11), FOS(1), GATA3(2), GATA4(2), GSK3A(1), GSK3B(3), HRAS(1), ICOS(2), IFNA1(1), IFNB1(2), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(1), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2D(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB2(1), NFKBIB(1), NPPB(1), NUP214(3), OPRD1(2), P2RX7(1), PAK1(2), PPP3CC(3), PTPRC(6), RELA(5), SLA(1), SP1(2), SP3(2), TRAF2(1), TRPV6(4), VAV1(3), VAV2(4), XPO5(3)	58343361	129	92	118	26	12	14	16	44	42	1	0.120	1.000	1.000
462	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(2), DLAT(2), DLD(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), OGDH(3), PC(3), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(2), PDK3(2), PDP2(2), SDHA(1), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(5), SUCLG2(2)	18653873	44	36	41	12	1	7	6	17	13	0	0.562	1.000	1.000
463	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFB(1), JUN(2), LMNB1(3), MADD(5), MAP3K1(5), MAP3K7(1), PAK1(2), PAK2(2), PRKDC(10), RB1(2), RIPK1(1), SPTAN1(6), TNFRSF1A(1), TRADD(2), TRAF2(1)	25861196	48	42	48	10	1	7	7	15	18	0	0.221	1.000	1.000
464	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT1(1), AKT2(3), AKT3(1), BCL10(1), CARD11(8), CD19(1), CD22(4), CD72(1), CHUK(1), CR2(2), FOS(1), GSK3B(3), HRAS(1), IKBKB(1), INPP5D(2), JUN(2), KRAS(1), LILRB3(3), MALT1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIB(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(2), PPP3CA(2), PPP3CC(3), PTPN6(3), RAC3(1), RASGRP3(1), SYK(1), VAV1(3), VAV2(4)	46727648	96	77	88	20	5	15	8	35	33	0	0.247	1.000	1.000
465	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(15), ATR(7), BRCA1(5), BRCA2(7), CHEK2(1), FANCA(4), FANCE(2), FANCF(2), FANCG(3), HUS1(2), MRE11A(1), RAD17(1), RAD50(4), RAD51(2), TREX1(2)	28845530	58	50	58	11	2	11	6	24	15	0	0.278	1.000	1.000
466	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(4), ATM(15), BRCA1(5), CDKN1A(1), CHEK2(1), JUN(2), MRE11A(1), NFKB1(1), RAD50(4), RAD51(2), RELA(5), TP73(3)	18875186	44	40	41	10	1	8	4	16	14	1	0.523	1.000	1.000
467	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(2), BIRC3(2), CASP8(1), CFLAR(1), JUN(2), MAP3K3(2), MAP3K7(1), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	17018286	23	22	23	7	0	5	5	9	4	0	0.512	1.000	1.000
468	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACSS1(2), ACSS2(7), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GALM(2), GAPDH(2), GAPDHS(2), HK1(5), LDHAL6B(1), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKL(1), PFKM(3), PFKP(2), PGAM2(1), PGK1(3), TPI1(1)	36532872	75	63	70	17	6	7	11	23	27	1	0.324	1.000	1.000
469	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(1), AKT2(3), AKT3(1), CD19(1), CSK(3), EPHB2(2), GRB2(2), ITPKB(2), NFAT5(6), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(5), SOS2(3), SYK(1), VAV1(3)	32093241	49	42	49	10	5	10	6	17	11	0	0.128	1.000	1.000
470	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSE(1), CYP11B2(2), CYP19A1(2), HSD17B1(1), HSD17B2(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SULT2A1(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3)	32479861	50	45	50	11	4	7	7	19	13	0	0.324	1.000	1.000
471	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	23	ASNS(1), CA14(3), CA5B(1), CA7(1), CA9(1), CPS1(4), CTH(1), GLS(3), GLS2(4), HAL(1)	13502425	20	19	20	7	1	2	2	14	1	0	0.790	1.000	1.000
472	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPS(1), CHPT1(2), ENPP2(1), PAFAH1B1(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(5), PPAP2B(1), PPAP2C(2)	15330061	21	20	19	9	3	2	2	9	5	0	0.901	1.000	1.000
473	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(1), EGFR(9), IGF1R(1), POLR2A(8), PPP2CA(1), PRKCA(2), RB1(2), TEP1(4), TERT(5), TNKS(4), XRCC5(3)	17815217	40	32	38	11	6	8	4	10	12	0	0.344	1.000	1.000
474	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(6), ACACB(4), ACSS1(2), ACSS2(7), AKR1B1(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), ME1(1), ME2(2), ME3(2), PC(3), PCK1(4), PCK2(1), PDHA1(1), PDHA2(2), PDHB(1)	29869547	57	48	55	13	2	8	11	12	23	1	0.341	1.000	1.000
475	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(3), AKT3(1), ASAH1(1), BRAF(2), DRD2(1), EGFR(9), EPHB2(2), GRB2(2), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), KCNJ3(3), PIK3CB(3), PITX2(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), RAF1(1), SHC1(3), SOS1(5), SOS2(3), SRC(1), STAT3(3)	38247862	74	56	72	16	8	12	12	26	15	1	0.120	1.000	1.000
476	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	44	AADAT(1), AASDHPPT(2), AASS(4), AKR1B10(2), ALDH1B1(1), ALDH2(2), ALDH7A1(1), BBOX1(1), DOT1L(2), ECHS1(2), EHHADH(5), EHMT1(3), EHMT2(3), HADH(1), HADHA(2), NSD1(8), OGDH(3), OGDHL(2), PLOD1(2), PLOD2(4), RDH11(3), SETD1A(4), SETD7(1), SETDB1(4), SHMT1(2), SHMT2(3), SPCS1(1), SUV39H2(4), TMLHE(1)	34947969	74	62	71	17	6	14	11	21	22	0	0.229	1.000	1.000
477	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(2), ADCY8(8), ATF4(2), BRAF(2), CACNA1C(9), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(5), EP300(11), GRIA1(6), GRIA2(3), GRIN1(2), GRIN2A(6), GRIN2B(6), GRM1(4), GRM5(7), HRAS(1), ITPR1(4), ITPR2(9), ITPR3(4), KRAS(1), MAPK3(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PPP1R12A(2), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), RAF1(1), RAP1A(1), RAPGEF3(1), RPS6KA6(1)	65282364	128	96	122	26	14	14	12	50	37	1	0.0854	1.000	1.000
478	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(5), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), ATP7A(3), ATP7B(5), COX10(2), NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB6(1), NDUFS1(5), NDUFS2(1), NDUFV1(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SHMT1(2), UQCRC1(1), UQCRFS1(1)	25317507	51	43	50	13	3	9	8	20	11	0	0.357	1.000	1.000
479	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(7), COL4A6(4), F11(1), F12(3), F2(2), F5(7), F8(5), F9(2), FGA(2), FGB(1), FGG(5), KLKB1(2), PROC(3), PROS1(4), SERPING1(2)	29418959	59	53	57	16	6	11	3	21	17	1	0.423	1.000	1.000
480	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(6), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), LDHC(3), MDH1(1), ME1(1), ME2(2), ME3(2), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1)	23470966	44	39	43	11	2	6	7	11	18	0	0.439	1.000	1.000
481	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(1), AKT2(3), AKT3(1), CD19(1), CDKN2A(3), FLOT2(1), GAB1(1), ITPR1(4), ITPR2(9), ITPR3(4), PDK1(1), PITX2(2), PLCG2(2), PPP1R13B(3), PREX1(6), PTPRC(6), RPS6KB1(2), SAG(5), SYK(1), TEC(5), VAV1(3)	33414521	64	58	64	15	5	12	9	20	18	0	0.164	1.000	1.000
482	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(1), AKT2(3), AKT3(1), CASP8(1), CCL3(1), CD86(1), CHUK(1), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IKBKB(1), IKBKE(1), IL1B(1), IRAK1(3), IRAK4(1), IRF5(1), IRF7(1), JUN(2), LBP(1), LY96(1), MAP2K3(2), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), NFKB1(1), NFKB2(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RELA(5), RIPK1(1), SPP1(3), STAT1(3), TBK1(2), TICAM1(3), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR6(1), TLR7(3), TLR8(5), TLR9(1), TRAF3(1), TRAF6(2)	56148144	102	86	97	20	8	16	11	48	18	1	0.105	1.000	1.000
483	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(1), AKT2(3), AKT3(1), CD19(1), CD22(4), CR2(2), CSK(3), FLOT2(1), GRB2(2), GSK3A(1), GSK3B(3), INPP5D(2), ITPR1(4), ITPR2(9), ITPR3(4), MAP4K1(1), MAPK3(1), NFATC1(2), NFATC2(5), PDK1(1), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP1R13B(3), PPP3CA(2), PPP3CC(3), PTPRC(6), RAF1(1), SHC1(3), SOS1(5), SOS2(3), SYK(1), VAV1(3)	46457051	86	64	80	18	8	15	9	26	28	0	0.127	1.000	1.000
484	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	CREBBP(5), CTBP1(1), CTBP2(1), DLL1(1), DLL4(2), DTX1(4), DTX3(1), DTX3L(1), DTX4(4), DVL1(1), DVL2(1), EP300(11), HDAC1(2), JAG1(5), JAG2(2), MAML1(5), MAML2(2), MAML3(4), NCOR2(6), NCSTN(1), NOTCH1(5), NOTCH2(9), NOTCH3(8), NOTCH4(5), NUMB(2), NUMBL(1), PSEN2(2), PSENEN(1), PTCRA(1), RBPJ(3), SNW1(3)	41218010	100	74	95	25	11	8	13	30	36	2	0.437	1.000	1.000
485	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(7), COL4A6(4), SLC23A1(4), SLC23A2(1), SLC2A1(1), SLC2A3(2)	16805555	28	27	28	10	3	10	1	9	5	0	0.704	1.000	1.000
486	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), CEL(1), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), GK(1), GLA(1), GLB1(5), LCT(2), LIPC(1), LIPF(1), LPL(2), PNLIP(4), PPAP2B(1), PPAP2C(2)	30913965	52	42	51	13	6	9	5	16	16	0	0.316	1.000	1.000
487	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(1), CAD(9), CANT1(1), DCTD(1), DPYD(4), DPYS(2), DTYMK(1), ENTPD5(1), NME7(1), NT5C1B(1), NT5C2(1), NT5M(2), POLA1(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLR1A(4), POLR1B(2), POLR1C(2), POLR2A(8), POLR2B(4), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(2), RFC5(1), RRM1(2), RRM2(1), TK1(1), TK2(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(1), UPB1(1), UPP2(2), UPRT(2)	53599149	88	68	82	17	3	16	11	28	29	1	0.0641	1.000	1.000
488	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GAPDH(2), GAPDHS(2), GOT1(3), GOT2(2), HK1(5), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PFKL(1), PFKM(3), PFKP(2), PGAM2(1), PGK1(3), TNFAIP1(1), TPI1(1)	26717209	61	50	59	17	4	6	9	15	27	0	0.584	1.000	1.000
489	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	107	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADSL(1), AK2(1), AK5(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(2), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), CANT1(1), ENPP3(1), ENTPD2(1), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HPRT1(1), IMPDH1(1), NPR1(4), NPR2(4), NT5M(2), PAPSS1(2), PAPSS2(2), PDE1A(1), PDE4A(2), PDE4B(1), PDE4D(1), PDE5A(1), PDE6B(3), PDE6C(2), PDE8A(2), PFAS(2), POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(9), POLR1B(2), POLR2A(8), POLR2B(4), POLR2I(1), POLRMT(2), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(2), RRM1(2), RRM2(1)	81841275	148	115	146	27	14	19	15	56	44	0	0.0260	1.000	1.000
490	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(15), CCNA1(7), CCND2(1), CCNE1(1), CCNE2(2), CCNG2(1), CCNH(1), CDC25A(1), CDK2(2), CDKN1A(1), CDKN2A(3), CDKN2C(1), CREB3L1(1), CREB3L4(3), E2F1(1), E2F5(1), GBA2(3), MCM2(6), MCM5(2), MCM6(3), MCM7(5), MNAT1(1), MYT1(2), PCNA(2), POLE(4), POLE2(1), PRIM1(2), RB1(2), RPA1(2), RPA2(1), RPA3(1), TFDP2(5), TNXB(5), WEE1(1)	45550661	90	67	85	19	5	9	8	32	36	0	0.295	1.000	1.000
491	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(7), ASAH1(1), DLG4(1), EPHB2(2), GNAI1(1), ITPR1(4), ITPR2(9), ITPR3(4), KCNJ3(3), PITX2(2), RHO(1), RYR1(13)	29642229	49	44	49	12	9	8	7	17	8	0	0.172	1.000	1.000
492	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(1), ASAH1(1), ATF1(2), BRAF(2), CREB5(2), CREBBP(5), EGR2(1), EGR3(1), ELK1(1), FRS2(2), JUN(2), MAP1B(7), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(5), PIK3C2G(2), PIK3CD(1), PIK3R1(2), PTPN11(1), SHC1(3), SRC(1), TH(2)	30792260	54	44	52	14	7	11	2	20	13	1	0.399	1.000	1.000
493	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(1), CREBBP(5), EHHADH(5), EP300(11), FABP1(3), JUN(2), LPL(2), MAPK3(1), ME1(1), NCOA1(2), NCOR1(4), NCOR2(6), NR1H3(2), NRIP1(4), PIK3R1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PTGS2(4), RB1(2), RELA(5), SP1(2), STAT5A(2), STAT5B(2)	39249679	78	56	69	19	4	10	8	26	29	1	0.410	1.000	1.000
494	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2), STAT5B(2)	18178229	40	37	38	11	4	6	3	16	11	0	0.730	1.000	1.000
495	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L4(3), CREBBP(5), CTNNB1(1), DCT(4), DVL1(1), DVL2(1), EDNRB(3), EP300(11), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD4(3), FZD5(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(5), GSK3B(3), HRAS(1), KITLG(2), KRAS(1), LEF1(1), MAPK3(1), MC1R(2), MITF(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), POMC(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), RAF1(1), TCF7L2(1), TYR(5), TYRP1(1), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1)	68695131	135	100	129	28	14	13	16	59	33	0	0.0728	1.000	1.000
496	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(2), ATM(15), ATR(7), BID(1), CASP8(1), CASP9(1), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(2), CCNG2(1), CD82(3), CDK2(2), CDKN1A(1), CDKN2A(3), CHEK2(1), FAS(1), GTSE1(2), IGFBP3(1), RCHY1(1), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(2), TP53I3(4), TP73(3), TSC2(5)	39240318	76	66	75	17	4	13	8	20	30	1	0.252	1.000	1.000
497	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(3), AKR1B10(2), ALDOA(1), ALDOB(3), FPGT(1), FUK(2), GMDS(1), GMPPA(1), GMPPB(1), HK1(5), KHK(3), MPI(1), MTMR1(1), MTMR2(1), PFKFB3(1), PFKL(1), PFKM(3), PFKP(2), PGM2(2), RDH11(3), TPI1(1)	23884258	39	36	39	11	7	3	6	10	13	0	0.564	1.000	1.000
498	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(6), DARS(1), EPRS(2), HARS(1), IARS(4), LARS(3), LARS2(2), MARS(2), MARS2(3), QARS(1), RARS(2), SARS(2), TARS(5), WARS(1), WARS2(1), YARS(1)	21368148	39	32	36	10	0	4	6	17	12	0	0.598	1.000	1.000
499	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	51	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GAPDH(2), HK1(5), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKM(3), PFKP(2), PGK1(3), TPI1(1)	30454568	59	50	55	16	6	4	7	20	22	0	0.588	1.000	1.000
500	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	51	ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GAPDH(2), HK1(5), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKM(3), PFKP(2), PGK1(3), TPI1(1)	30454568	59	50	55	16	6	4	7	20	22	0	0.588	1.000	1.000
501	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	67	ACACB(4), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(1), AKT2(3), AKT3(1), CAMKK1(2), CAMKK2(2), CHUK(1), CPT1A(1), CPT1C(4), CPT2(1), G6PC(3), IKBKB(1), IRS1(4), IRS4(1), JAK1(4), JAK2(5), JAK3(3), LEP(1), LEPR(1), MAPK10(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIB(1), NPY(1), PCK1(4), PCK2(1), POMC(1), PPARGC1A(3), PRKAB1(1), PRKAG1(4), PRKAG2(4), PRKCQ(4), PTPN11(1), RELA(5), RXRB(4), RXRG(2), SLC2A1(1), SOCS3(1), STAT3(3), TNFRSF1A(1), TRADD(2), TRAF2(1), TYK2(6)	50882618	107	86	101	26	5	15	18	32	36	1	0.533	1.000	1.000
502	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(3), AKT3(1), ARHGEF11(5), CDC42(1), DLG4(1), GNA13(4), LPA(6), MAP3K1(5), MAP3K5(5), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(3), PLD1(2), PLD2(5), PLD3(3), PTK2(1), RDX(1), ROCK1(4), ROCK2(2), TBXA2R(2)	31808522	63	54	59	15	4	7	7	26	19	0	0.447	1.000	1.000
503	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(3), BTG1(2), CLOCK(1), EIF4G2(3), ETV6(2), HERPUD1(1), HSPA8(7), IDI1(1), KLF9(2), MYF6(2), NCKAP1(1), NCOA4(5), NR1D2(1), PER1(4), PER2(4), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(1), TOB1(2), UGP2(1), ZFR(4)	23817899	51	48	50	14	2	7	10	17	15	0	0.490	1.000	1.000
504	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(4), ABL2(4), AKT1(1), AKT2(3), AKT3(1), BRAF(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(2), CBLC(1), CDKN1A(1), EGF(4), EGFR(9), ELK1(1), ERBB2(4), ERBB3(4), ERBB4(6), GAB1(1), GRB2(2), GSK3B(3), HRAS(1), JUN(2), KRAS(1), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK9(2), NCK1(1), NRG1(1), NRG2(2), NRG3(2), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCG(2), PTK2(1), RAF1(1), RPS6KB1(2), RPS6KB2(2), SHC1(3), SHC2(1), SOS1(5), SOS2(3), SRC(1), STAT5A(2), STAT5B(2)	65348562	131	94	123	29	11	21	16	45	37	1	0.202	1.000	1.000
505	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMP7(3), BMP8B(1), BTRC(2), CSNK1A1(2), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(4), GLI2(4), GLI3(5), GSK3B(3), HHIP(3), LRP2(17), PRKACA(1), PRKACB(2), PRKACG(2), PTCH1(9), PTCH2(2), SHH(1), SMO(3), STK36(2), SUFU(1), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1)	37099931	84	71	77	22	10	9	6	37	22	0	0.508	1.000	1.000
506	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(2), BID(1), BIRC2(2), BIRC3(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), FAS(1), JUN(2), MAP3K1(5), MAPK10(1), NFKB1(1), PARP1(3), PRF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	23109204	35	30	32	10	0	8	5	10	11	1	0.585	1.000	1.000
507	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(2), G6PC(3), GAA(1), GALK1(1), GALK2(1), GALT(3), GANC(2), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(2), MGAM(5), PFKL(1), PFKM(3), PFKP(2), RDH11(3), UGP2(1)	24901001	45	40	44	13	4	6	6	13	16	0	0.597	1.000	1.000
508	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), ALAS1(5), ALAS2(3), AOC2(3), AOC3(1), BHMT(2), CHDH(2), CHKB(2), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(1), GLDC(3), MAOA(1), PISD(1), PLCB2(2), PLCG1(2), PLCG2(2), SARDH(3), SARS(2), SHMT1(2), SHMT2(3), TARS(5)	27427385	54	50	50	15	5	7	9	14	19	0	0.499	1.000	1.000
509	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP2K7(1), MAP3K1(5), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PAK2(2), PIK3R1(2), PLA2G4A(1), PLCG1(2), PPP3CA(2), PPP3CC(3), RAF1(1), SHC1(3), SOS1(5), SYK(1), SYT1(1), VAV1(3)	26213157	56	49	53	16	6	8	4	18	20	0	0.653	1.000	1.000
510	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG1(1), ASL(4), ASS1(2), CPS1(4), DAO(1), EPRS(2), GATM(1), GOT1(3), GOT2(2), LAP3(2), NOS1(9), NOS3(2), OAT(1), OTC(1), P4HA1(3), P4HA2(1), PARS2(3), PRODH(1), PYCR1(1), PYCR2(1), RARS(2)	23285057	48	43	48	14	3	5	11	17	12	0	0.609	1.000	1.000
511	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(2), EIF1(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(2), EIF2S2(2), FLT1(7), FLT4(7), HIF1A(3), HRAS(1), KDR(5), NOS3(2), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(1), PXN(1), SHC1(3)	20668553	47	43	46	14	4	6	4	16	17	0	0.726	1.000	1.000
512	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(4), DIAPH1(3), FYN(2), GSN(2), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), MYL2(1), MYLK(4), PIK3R1(2), PTK2(1), PXN(1), RAF1(1), ROCK1(4), SHC1(3), SRC(1), TLN1(6)	23089300	46	42	45	13	4	7	2	17	16	0	0.648	1.000	1.000
513	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	56	AADAT(1), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOC2(3), AOC3(1), AOX1(7), CAT(2), CYP1A1(1), CYP1A2(3), CYP1B1(1), DDC(2), ECHS1(2), EHHADH(5), HAAO(1), HADH(1), HADHA(2), LCMT1(1), LCMT2(3), MAOA(1), NFX1(1), OGDH(3), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), TPH1(1), TPH2(1), WARS(1), WARS2(1)	38324561	59	53	58	15	4	12	10	20	13	0	0.330	1.000	1.000
514	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	50	ALG6(2), CCKBR(1), CELSR1(11), CELSR2(6), CELSR3(5), CHRM2(3), CHRM3(2), CIDEB(1), EMR2(2), FSHR(2), GPR116(4), GPR133(3), GPR143(1), GPR17(2), GPR61(1), GPR84(3), GRM1(4), GRPR(1), HRH4(1), LGR6(2), LPHN2(3), LPHN3(8), NTSR1(1), P2RY11(1), P2RY13(1), PTGFR(3), SMO(3), TSHR(2)	40575118	79	59	78	21	12	14	6	25	22	0	0.285	1.000	1.000
515	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT3(2), B4GALT4(2), B4GALT6(1), FUT6(2), GBGT1(2), GCNT2(2), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(2), PIGO(4), PIGP(1), PIGQ(3), PIGT(6), PIGU(1), PIGV(1), PIGZ(3), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	30918368	65	54	60	19	5	9	8	18	24	1	0.702	1.000	1.000
516	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), ACTN2(3), BCAR1(3), CAPN1(1), CSK(3), FYN(2), GRB2(2), HRAS(1), ITGA1(5), ITGB1(4), JUN(2), MAPK3(1), PPP1R12B(1), PTK2(1), PXN(1), RAF1(1), RAP1A(1), ROCK1(4), SHC1(3), SOS1(5), SRC(1), TLN1(6), VCL(2), ZYX(1)	30457734	55	46	54	15	4	8	2	26	15	0	0.633	1.000	1.000
517	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(2), BID(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), CHUK(1), DFFB(1), FAS(1), HELLS(2), IKBKB(1), IRF5(1), IRF6(5), IRF7(1), JUN(2), LTA(1), MAP3K1(5), MAPK10(1), NFKB1(1), NFKBIB(1), PRF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TNFRSF21(1), TP73(3), TRADD(2), TRAF2(1), TRAF3(1)	35660710	55	44	48	14	1	9	5	18	21	1	0.607	1.000	1.000
518	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSE(1), ASAH1(1), B4GALT6(1), CERK(5), DEGS1(2), ENPP7(2), GAL3ST1(2), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SGPP1(2), SMPD2(2), SPHK2(1), SPTLC1(1), UGT8(1)	22215704	37	33	34	12	4	7	5	10	11	0	0.685	1.000	1.000
519	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTB(1), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(2), AKT1(1), AKT2(3), AKT3(1), ARHGAP5(4), BCAR1(3), BIRC2(2), BIRC3(2), BRAF(2), CAPN2(2), CAV2(1), CCND2(1), CDC42(1), CHAD(2), COL11A1(8), COL11A2(4), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(4), COL5A2(5), COL5A3(10), COL6A1(1), COL6A2(6), COL6A3(12), COL6A6(13), CTNNB1(1), DIAPH1(3), DOCK1(1), EGF(4), EGFR(9), ELK1(1), ERBB2(4), FARP2(2), FIGF(1), FLNA(4), FLNB(4), FLNC(5), FLT1(7), FN1(4), FYN(2), GRB2(2), GSK3B(3), HGF(1), HRAS(1), IBSP(1), IGF1R(1), ILK(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAV(1), ITGB1(4), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), JUN(2), KDR(5), LAMA1(9), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(5), LAMC2(6), LAMC3(5), MAPK10(1), MAPK3(1), MAPK9(2), MET(6), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PARVB(1), PARVG(1), PDGFC(1), PDGFD(2), PDGFRA(5), PDGFRB(1), PGF(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP5K1C(1), PPP1R12A(2), PRKCA(2), PRKCG(2), PTK2(1), PXN(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF1(3), RELN(5), ROCK1(4), ROCK2(2), SHC1(3), SHC2(1), SOS1(5), SOS2(3), SPP1(3), SRC(1), THBS2(1), THBS3(4), THBS4(1), TLN1(6), TLN2(8), TNC(8), TNN(2), TNR(8), TNXB(5), VAV1(3), VAV2(4), VCL(2), VEGFC(2), VTN(1), VWF(11), ZYX(1)	235996186	473	246	457	139	49	67	49	162	144	2	0.571	1.000	1.000
520	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	165	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY7(1), ADCY8(8), ADCY9(4), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A2(6), ATP2B1(1), ATP2B3(1), ATP2B4(3), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(5), CACNA1B(4), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(7), CACNA1H(3), CACNA1I(3), CACNA1S(8), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKAR(2), CCKBR(1), CD38(1), CHRM2(3), CHRM3(2), CHRM5(2), CHRNA7(1), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(9), ERBB2(4), ERBB3(4), ERBB4(6), GNA15(1), GNAS(5), GRIN1(2), GRIN2A(6), GRM1(4), GRM5(7), GRPR(1), HRH2(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), MYLK(4), MYLK2(1), NOS1(9), NOS3(2), NTSR1(1), P2RX1(2), P2RX2(3), P2RX3(2), P2RX7(1), PDE1A(1), PDE1B(5), PDE1C(1), PDGFRA(5), PDGFRB(1), PHKA1(5), PHKA2(3), PHKB(2), PHKG1(2), PHKG2(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PPID(1), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), PTAFR(1), PTGFR(3), PTK2B(3), RYR1(13), RYR2(11), RYR3(13), SLC25A4(2), SLC25A6(1), SLC8A1(1), SLC8A2(2), SLC8A3(3), SPHK2(1), TACR1(1), TACR3(2), TBXA2R(2), TRHR(2), TRPC1(2), VDAC3(1)	173693779	351	222	341	93	52	47	29	131	92	0	0.120	1.000	1.000
521	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(3), ACVR1C(3), AKT1(1), AKT2(3), AKT3(1), ARRB2(1), ATF2(1), ATF4(2), BRAF(2), CACNA1A(5), CACNA1B(4), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(7), CACNA1H(3), CACNA1I(3), CACNA1S(8), CACNA2D1(3), CACNA2D4(3), CACNB1(1), CACNB2(1), CACNB4(1), CACNG3(2), CACNG5(1), CACNG6(1), CACNG7(1), CDC25B(1), CDC42(1), CHUK(1), DAXX(5), DUSP10(1), DUSP3(2), DUSP4(1), DUSP5(1), DUSP8(1), DUSP9(1), ECSIT(4), EGF(4), EGFR(9), ELK1(1), ELK4(2), FAS(1), FGF10(1), FGF11(1), FGF13(1), FGF14(1), FGF19(1), FGF20(1), FGF3(1), FGF6(2), FGF7(2), FGFR1(5), FGFR2(4), FGFR3(1), FGFR4(3), FLNA(4), FLNB(4), FLNC(5), FOS(1), GNA12(1), GRB2(2), HRAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1R2(4), JUN(2), KRAS(1), MAP2K3(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP4K1(1), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK2(1), MAPT(3), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), NF1(9), NFATC2(5), NFATC4(3), NFKB1(1), NFKB2(1), NTRK1(5), NTRK2(1), PAK1(2), PAK2(2), PDGFRA(5), PDGFRB(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PPM1B(2), PPP3CA(2), PPP3CC(3), PPP5C(2), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), PTPN5(3), PTPN7(1), PTPRR(3), RAC3(1), RAF1(1), RAP1A(1), RAPGEF2(7), RASA1(3), RASA2(1), RASGRF1(3), RASGRF2(3), RASGRP1(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA4(1), RPS6KA5(1), RPS6KA6(1), SOS1(5), SOS2(3), TAOK2(2), TAOK3(1), TGFB2(1), TGFBR2(1), TNFRSF1A(1), TRAF2(1), TRAF6(2), ZAK(3)	185002022	350	216	342	82	36	53	31	132	97	1	0.0710	1.000	1.000
522	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(1), ACTG1(3), CHAD(2), COL11A1(8), COL11A2(4), COL17A1(3), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(4), COL5A2(5), COL5A3(10), COL6A1(1), COL6A2(6), COL6A3(12), COL6A6(13), DSC2(2), DSG1(3), DSG2(2), DSG3(2), DSG4(2), FN1(4), GJA10(2), GJA3(1), GJA5(5), GJA8(1), GJA9(1), GJB1(1), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(1), IBSP(1), ITGA6(4), ITGB4(2), KRT1(1), KRT10(1), KRT12(2), KRT13(3), KRT15(1), KRT16(1), KRT17(2), KRT19(1), KRT2(2), KRT23(2), KRT24(1), KRT25(1), KRT27(2), KRT28(2), KRT3(1), KRT31(1), KRT33B(2), KRT36(2), KRT39(1), KRT4(4), KRT5(2), KRT6A(1), KRT6B(2), KRT6C(1), KRT7(1), KRT71(2), KRT72(2), KRT73(2), KRT74(2), KRT75(3), KRT76(1), KRT77(1), KRT78(3), KRT79(4), KRT82(2), KRT83(1), KRT84(2), KRT85(4), KRT86(1), LAMA1(9), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(5), LAMC2(6), LAMC3(5), LMNB1(3), NES(6), PRPH(1), RELN(5), SPP1(3), THBS2(1), THBS3(4), THBS4(1), TNC(8), TNN(2), TNR(8), TNXB(5), VIM(1), VTN(1), VWF(11)	156183862	331	201	323	108	38	49	31	102	110	1	0.799	1.000	1.000
523	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	198	ABI2(2), ACTN1(1), ACTN2(3), ACTN4(2), APC(7), ARHGEF1(2), ARHGEF12(2), ARHGEF6(2), ARHGEF7(4), ARPC5L(1), BCAR1(3), BDKRB1(1), BDKRB2(1), BRAF(2), CDC42(1), CFL1(1), CHRM2(3), CHRM3(2), CHRM5(2), CSK(3), CYFIP1(5), CYFIP2(5), DIAPH1(3), DIAPH2(2), DIAPH3(4), DOCK1(1), EGF(4), EGFR(9), EZR(1), F2(2), FGD1(2), FGF10(1), FGF11(1), FGF13(1), FGF14(1), FGF19(1), FGF20(1), FGF3(1), FGF6(2), FGF7(2), FGFR1(5), FGFR2(4), FGFR3(1), FGFR4(3), FN1(4), GIT1(1), GNA12(1), GNA13(4), GSN(2), HRAS(1), IQGAP1(3), IQGAP2(3), IQGAP3(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAD(9), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(3), ITGB1(4), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), KRAS(1), LIMK1(4), LIMK2(2), MAPK3(1), MOS(1), MRAS(1), MSN(2), MYH10(2), MYH14(4), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), NCKAP1(1), NCKAP1L(3), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDGFRA(5), PDGFRB(1), PFN4(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(1), PPP1R12A(2), PPP1R12B(1), PTK2(1), PXN(1), RAC3(1), RAF1(1), RDX(1), ROCK1(4), ROCK2(2), SCIN(1), SLC9A1(2), SOS1(5), SOS2(3), SSH1(2), SSH2(8), SSH3(2), TIAM1(6), TIAM2(1), VAV1(3), VAV2(4), VCL(2), WASF2(2)	178617979	333	199	318	86	24	38	41	123	106	1	0.453	1.000	1.000
524	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(2), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRA2B(1), ADRB2(2), AGTR1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), C5AR1(2), CALCR(2), CALCRL(1), CCKAR(2), CCKBR(1), CGA(1), CHRM2(3), CHRM3(2), CHRM5(2), CNR1(1), CNR2(2), CRHR1(1), CRHR2(2), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(3), F2(2), F2RL1(1), F2RL2(1), FPR1(2), FSHR(2), GABBR1(3), GABRA1(2), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRB1(2), GABRB3(1), GABRE(3), GABRG1(2), GABRG2(3), GABRQ(7), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(1), GLP1R(1), GLP2R(2), GLRA1(2), GLRA2(1), GLRB(1), GPR156(1), GPR35(2), GPR50(1), GPR63(1), GPR83(1), GRIA1(6), GRIA2(3), GRIA3(2), GRIA4(3), GRID1(3), GRID2(6), GRIK1(2), GRIK2(4), GRIK3(4), GRIK5(4), GRIN1(2), GRIN2A(6), GRIN2B(6), GRIN3B(2), GRM1(4), GRM2(2), GRM3(3), GRM4(3), GRM5(7), GRM6(2), GRM7(4), GRM8(2), GRPR(1), HRH2(1), HRH4(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), LEP(1), LEPR(1), MAS1(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR2(2), MTNR1B(1), NMUR2(4), NPBWR1(1), NPBWR2(1), NPFFR2(2), NTSR1(1), OPRD1(2), OPRL1(1), OPRM1(3), P2RX1(2), P2RX2(3), P2RX3(2), P2RX7(1), P2RY1(1), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY4(1), P2RY8(2), PARD3(5), PRLR(2), PRSS3(2), PTAFR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), RXFP1(1), RXFP2(1), SCTR(1), SSTR1(1), SSTR3(1), SSTR4(1), TAAR2(1), TACR1(1), TACR3(2), TBXA2R(2), THRA(1), TRHR(2), TRPV1(1), TSHR(2), VIPR1(1)	139731549	283	184	274	84	39	37	27	108	72	0	0.474	1.000	1.000
525	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(5), CD44(2), CHAD(2), COL11A1(8), COL11A2(4), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(4), COL5A2(5), COL5A3(10), COL6A1(1), COL6A2(6), COL6A3(12), COL6A6(13), FN1(4), FNDC1(1), FNDC3A(2), FNDC5(1), HMMR(1), HSPG2(9), IBSP(1), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAV(1), ITGB1(4), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), LAMA1(9), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(5), LAMC2(6), LAMC3(5), RELN(5), SDC3(1), SPP1(3), SV2A(1), SV2B(1), SV2C(1), THBS2(1), THBS3(4), THBS4(1), TNC(8), TNN(2), TNR(8), TNXB(5), VTN(1), VWF(11)	141406088	281	182	274	90	30	42	28	85	95	1	0.780	1.000	1.000
526	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ADRA1A(4), ADRB2(2), ANXA6(2), ARRB2(1), ATP1A4(4), ATP2A2(6), ATP2B1(1), ATP2B3(1), CACNA1A(5), CACNA1B(4), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1S(8), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(4), CASQ2(2), CHRM2(3), CHRM3(2), CHRM5(2), GJA5(5), GJB1(1), GJB3(1), GJB6(2), GNAI2(1), GNAO1(1), GNAZ(1), GNB1(2), GNB3(2), GNB5(2), GNG3(1), GRK4(1), GRK5(1), GRK6(5), ITPR1(4), ITPR2(9), ITPR3(4), KCNB1(1), KCNJ3(3), MYCBP(1), NME7(1), PKIA(1), PLCB3(2), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RGS11(1), RGS17(2), RGS18(2), RGS2(2), RGS3(3), RGS6(2), RGS9(4), RYR1(13), RYR2(11), RYR3(13), SLC8A1(1), SLC8A3(3), USP5(2), YWHAB(1)	123464952	248	164	242	68	41	32	19	87	69	0	0.187	1.000	1.000
527	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(4), ABLIM1(4), ABLIM2(1), ABLIM3(3), ARHGEF12(2), CDC42(1), CFL1(1), CXCR4(1), DCC(4), DPYSL2(2), EFNA3(1), EFNB1(1), EPHA1(3), EPHA3(2), EPHA4(1), EPHA5(5), EPHA6(2), EPHA7(1), EPHA8(3), EPHB1(1), EPHB2(2), EPHB4(4), EPHB6(5), FES(3), FYN(2), GNAI1(1), GNAI2(1), GSK3B(3), HRAS(1), ITGB1(4), KRAS(1), L1CAM(5), LIMK1(4), LIMK2(2), MAPK3(1), MET(6), NCK1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NGEF(1), NRP1(2), NTN4(2), NTNG1(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PLXNA1(2), PLXNA2(2), PLXNA3(3), PLXNB1(4), PLXNB2(3), PLXNC1(3), PPP3CA(2), PPP3CC(3), PTK2(1), RAC3(1), RASA1(3), RGS3(3), RND1(2), ROBO1(2), ROBO2(5), ROBO3(1), ROCK1(4), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(2), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(1), SEMA4G(2), SEMA5A(5), SEMA5B(1), SEMA6C(4), SEMA6D(3), SLIT1(2), SLIT2(7), SLIT3(5), SRGAP1(4), SRGAP2(1), SRGAP3(3), UNC5A(2), UNC5B(3), UNC5C(2), UNC5D(2)	124146703	233	153	219	61	18	28	21	82	83	1	0.493	1.000	1.000
528	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(1), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(2), AKT1(1), AKT2(3), AKT3(1), AMOTL1(1), ASH1L(4), CASK(1), CDC42(1), CGN(1), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(1), CLDN4(2), CLDN6(1), CLDN7(1), CSNK2A2(1), CSNK2B(1), CTNNA1(4), CTNNA2(4), CTNNA3(2), CTNNB1(1), EPB41(2), EPB41L1(1), EPB41L2(1), EPB41L3(4), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), HRAS(1), INADL(4), JAM3(1), KRAS(1), LLGL1(5), LLGL2(1), MAGI1(3), MAGI2(4), MAGI3(4), MLLT4(8), MPDZ(4), MPP5(1), MRAS(1), MYH1(4), MYH10(2), MYH11(8), MYH13(3), MYH14(4), MYH15(3), MYH2(9), MYH3(5), MYH4(10), MYH6(4), MYH7(8), MYH7B(4), MYH8(5), MYL2(1), MYL7(1), MYL9(1), OCLN(2), PARD3(5), PARD6B(4), PPM1J(3), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(1), SPTAN1(6), SRC(1), TJAP1(1), TJP1(2), TJP2(2), TJP3(1), YES1(1), ZAK(3)	125528866	235	153	227	72	24	29	16	79	86	1	0.821	1.000	1.000
529	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ARRB2(1), ATF1(2), ATF2(1), ATF4(2), ATF5(1), ATP2A2(6), CALCA(1), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(3), CORIN(2), CRHR1(1), DGKZ(2), ETS2(1), FOS(1), GABPA(1), GABPB2(1), GBA2(3), GNB1(2), GNB3(2), GNB5(2), GNG3(1), GRK4(1), GRK5(1), GRK6(5), GSTO1(1), GUCA2A(1), GUCY1A3(2), IGFBP2(2), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL1B(1), ITPR1(4), ITPR2(9), ITPR3(4), JUN(2), MYL2(1), MYLK2(1), NFKB1(1), NOS1(9), NOS3(2), PDE4B(1), PDE4D(1), PKIA(1), PLCB3(2), PLCD1(1), PLCG1(2), PLCG2(2), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(1), RGS11(1), RGS17(2), RGS18(2), RGS2(2), RGS3(3), RGS6(2), RGS9(4), RLN1(1), RYR1(13), RYR2(11), RYR3(13), SLC8A1(1), SP1(2), TNXB(5), USP5(2), YWHAB(1)	111119861	225	153	221	54	34	32	19	79	61	0	0.132	1.000	1.000
530	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	248	ACVR1(1), ACVR1B(3), ACVR2A(1), ACVR2B(1), BMP2(1), BMP7(3), BMPR1B(1), BMPR2(5), CCL2(1), CCL27(1), CCL3(1), CCR6(1), CCR9(1), CD27(1), CLCF1(1), CSF1R(4), CSF2RA(2), CSF2RB(1), CSF3R(2), CX3CR1(1), CXCL11(1), CXCL9(1), CXCR4(1), CXCR6(1), EDA(1), EGF(4), EGFR(9), FAS(1), FLT1(7), FLT3(6), FLT4(7), GDF5(1), GH2(1), GHR(1), HGF(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNGR1(2), IFNGR2(2), IFNK(1), IL11RA(1), IL12RB1(2), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(1), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(3), IL19(2), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(4), IL20RA(1), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL6ST(3), IL9R(2), INHBA(2), INHBB(1), INHBC(1), INHBE(1), KDR(5), KITLG(2), LEP(1), LEPR(1), LIFR(2), LTA(1), LTB(1), LTBR(2), MET(6), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(5), PDGFRB(1), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(1), TGFBR2(1), TNFRSF10C(1), TNFRSF11B(1), TNFRSF13B(1), TNFRSF1A(1), TNFRSF21(1), TNFRSF4(1), TNFRSF9(1), TNFSF14(1), TNFSF15(1), TNFSF9(1), TPO(4), VEGFC(2), XCL1(1), XCR1(1)	113984327	210	151	203	41	16	30	21	85	58	0	0.0278	1.000	1.000
531	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(6), ACACB(4), AKT1(1), AKT2(3), AKT3(1), BRAF(2), CALM2(1), CBL(2), CBLB(2), CBLC(1), ELK1(1), EXOC7(4), FASN(3), FLOT2(1), FOXO1(1), G6PC(3), GRB2(2), GSK3B(3), GYS1(3), GYS2(1), HRAS(1), IKBKB(1), INPP5D(2), INSR(4), IRS1(4), IRS4(1), KRAS(1), LIPE(4), MAPK10(1), MAPK3(1), MAPK9(2), MKNK1(2), MKNK2(1), PCK1(4), PCK2(1), PDE3A(3), PDE3B(1), PFKL(1), PFKM(3), PFKP(2), PHKA1(5), PHKA2(3), PHKB(2), PHKG1(2), PHKG2(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPARGC1A(3), PPP1R3A(3), PPP1R3C(1), PPP1R3D(1), PRKAB1(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAG2(4), PRKAR1A(2), PRKAR2B(2), PRKCI(2), PRKCZ(1), PTPN1(1), PTPRF(4), PYGB(2), PYGL(1), PYGM(3), RAF1(1), RAPGEF1(3), RHEB(3), RHOQ(1), RPS6KB1(2), RPS6KB2(2), SH2B2(1), SHC1(3), SHC2(1), SOCS3(1), SOCS4(1), SORBS1(1), SOS1(5), SOS2(3), SREBF1(2), TRIP10(1), TSC1(1), TSC2(5)	100446358	189	139	180	35	18	27	20	71	51	2	0.0177	1.000	1.000
532	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(7), AXIN1(2), AXIN2(1), BTRC(2), CACYBP(3), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CHD8(3), CREBBP(5), CSNK1A1(2), CSNK2A2(1), CSNK2B(1), CTBP1(1), CTBP2(1), CTNNB1(1), CUL1(3), CXXC4(2), DAAM1(2), DVL1(1), DVL2(1), EP300(11), FBXW11(1), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD4(3), FZD5(1), GSK3B(3), JUN(2), LEF1(1), LRP5(3), LRP6(4), MAP3K7(1), MAPK10(1), MAPK9(2), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NKD1(2), NKD2(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), PPP3CA(2), PPP3CC(3), PRICKLE1(3), PRICKLE2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), RAC3(1), ROCK1(4), ROCK2(2), SENP2(1), SFRP2(1), SFRP4(2), SFRP5(1), SMAD2(2), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(3), TCF7L2(1), VANGL1(1), VANGL2(3), WIF1(4), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1)	101616687	188	132	178	50	11	20	24	72	61	0	0.498	1.000	1.000
533	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	128	ALCAM(2), CADM1(2), CADM3(1), CD2(2), CD22(4), CD28(1), CD34(2), CD6(2), CD86(1), CD8A(1), CDH1(1), CDH2(6), CDH3(3), CDH4(4), CDH5(3), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(1), CLDN4(2), CLDN6(1), CLDN7(1), CNTN1(4), CNTN2(2), CNTNAP1(7), CNTNAP2(5), CTLA4(1), ESAM(1), F11R(1), GLG1(4), HLA-B(1), HLA-C(2), HLA-DPA1(1), HLA-DPB1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(1), HLA-E(2), HLA-F(1), ICAM1(1), ICOS(2), ICOSLG(1), ITGA4(2), ITGA6(4), ITGA9(1), ITGAL(5), ITGAM(5), ITGAV(1), ITGB1(4), ITGB2(1), ITGB7(3), ITGB8(1), JAM3(1), L1CAM(5), MPZL1(1), NCAM2(1), NEGR1(2), NEO1(2), NFASC(5), NRCAM(2), NRXN1(7), NRXN2(3), NRXN3(3), OCLN(2), PTPRC(6), PTPRF(4), PTPRM(3), PVRL2(3), PVRL3(2), SDC3(1), SELE(4), SELP(2), SELPLG(2), SIGLEC1(2), SPN(1), VCAM1(3), VCAN(6)	92698422	186	131	181	60	15	25	22	74	50	0	0.790	1.000	1.000
534	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	147	AKT1(1), AKT2(3), AKT3(1), CBL(2), CBLB(2), CBLC(1), CCND2(1), CLCF1(1), CREBBP(5), CSF2RA(2), CSF2RB(1), CSF3R(2), EP300(11), GH2(1), GHR(1), GRB2(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNGR1(2), IFNGR2(2), IFNK(1), IL11RA(1), IL12RB1(2), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(1), IL19(2), IL20RA(1), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL6ST(3), IL9R(2), IRF9(2), JAK1(4), JAK2(5), JAK3(3), LEP(1), LEPR(1), LIFR(2), OSMR(1), PIAS1(4), PIAS2(1), PIAS3(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRLR(2), PTPN11(1), PTPN6(3), SOCS3(1), SOCS4(1), SOCS5(1), SOS1(5), SOS2(3), SPRED2(1), SPRY1(1), SPRY2(2), STAM(2), STAT1(3), STAT2(6), STAT3(3), STAT4(1), STAT5A(2), STAT5B(2), STAT6(4), TPO(4), TYK2(6)	92166575	187	130	180	46	12	26	27	66	56	0	0.271	1.000	1.000
535	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ATF4(2), CACNA1C(9), CACNA1D(6), CACNA1F(4), CACNA1S(8), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), CGA(1), EGFR(9), ELK1(1), GNAS(5), GRB2(2), HRAS(1), ITPR1(4), ITPR2(9), ITPR3(4), JUN(2), KRAS(1), MAP2K3(2), MAP2K7(1), MAP3K1(5), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK9(2), MMP14(1), MMP2(6), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLD1(2), PLD2(5), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCD(3), PTK2B(3), RAF1(1), SOS1(5), SOS2(3), SRC(1)	84485985	180	125	176	45	23	27	19	71	40	0	0.139	1.000	1.000
536	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(1), BCAR1(3), CAPN1(1), CAPN10(1), CAPN11(1), CAPN2(2), CAPN3(6), CAPN6(2), CAPN7(1), CAPN9(2), CAV2(1), CDC42(1), CSK(3), DOCK1(1), FYN(2), GIT2(2), GRB2(2), ILK(4), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAD(9), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(3), ITGB1(4), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK4(1), MAPK7(1), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PIK3R2(2), PTK2(1), PXN(1), RAC3(1), RAPGEF1(3), RHO(1), ROCK1(4), ROCK2(2), SDCCAG8(1), SEPP1(1), SHC1(3), SORBS1(1), SOS1(5), SRC(1), TLN1(6), TNS1(7), VAV2(4), VCL(2), ZYX(1)	88189962	171	123	162	48	9	26	19	58	59	0	0.590	1.000	1.000
537	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ADSL(1), ADSSL1(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(2), CANT1(1), ENPP3(1), ENTPD2(1), ENTPD5(1), GART(1), GDA(1), GMPR(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HPRT1(1), IMPDH1(1), NME7(1), NPR1(4), NPR2(4), NT5C1B(1), NT5C2(1), NT5M(2), NUDT9(1), PAPSS1(2), PAPSS2(2), PDE10A(1), PDE11A(5), PDE1A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(1), PDE4D(1), PDE5A(1), PDE8A(2), PDE8B(1), PFAS(2), POLA1(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLR1A(4), POLR1B(2), POLR1C(2), POLR2A(8), POLR2B(4), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(2), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(2), RFC5(1), RRM1(2), RRM2(1), XDH(5)	105598011	170	122	168	32	12	26	18	64	50	0	0.0239	1.000	1.000
538	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), DRD1(1), DRD2(1), EGF(4), EGFR(9), GJD2(1), GNAI1(1), GNAI2(1), GNAS(5), GRB2(2), GRM1(4), GRM5(7), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HRAS(1), HTR2A(1), HTR2C(1), ITPR1(4), ITPR2(9), ITPR3(4), KRAS(1), MAP2K5(1), MAP3K2(2), MAPK3(1), MAPK7(1), NPR1(4), NPR2(4), PDGFC(1), PDGFD(2), PDGFRA(5), PDGFRB(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), PRKG1(3), PRKG2(2), RAF1(1), SOS1(5), SOS2(3), SRC(1), TJP1(2), TUBA1A(2), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2)	85841526	175	121	171	39	19	25	17	68	46	0	0.152	1.000	1.000
539	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(3), ACTN4(2), DMD(7), MYBPC1(2), MYBPC2(3), MYH3(5), MYH6(4), MYH7(8), MYH8(5), MYL1(3), MYL2(1), MYL9(1), MYOM1(5), NEB(12), TMOD1(5), TNNI1(2), TNNT1(2), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TTN(83), VIM(1)	93467529	158	120	154	44	14	28	14	63	36	3	0.421	1.000	1.000
540	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACP1(1), ACTB(1), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(2), ACVR1B(3), ACVR1C(3), CDC42(1), CDH1(1), CREBBP(5), CSNK2A2(1), CSNK2B(1), CTNNA1(4), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(5), EGFR(9), EP300(11), ERBB2(4), FARP2(2), FER(2), FGFR1(5), FYN(2), IGF1R(1), INSR(4), IQGAP1(3), LEF1(1), MAP3K7(1), MAPK3(1), MET(6), MLLT4(8), PARD3(5), PTPN1(1), PTPN6(3), PTPRB(3), PTPRF(4), PTPRJ(7), PTPRM(3), PVRL2(3), PVRL3(2), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(2), SORBS1(1), SRC(1), SSX2IP(1), TCF7L2(1), TGFBR2(1), TJP1(2), VCL(2), WASF2(2), WASF3(2), YES1(1)	75775651	155	118	143	40	17	13	22	58	45	0	0.379	1.000	1.000
541	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(4), ANAPC1(4), ANAPC2(1), ANAPC4(5), ANAPC5(1), ANAPC7(2), ATM(15), ATR(7), BUB1B(1), BUB3(1), CCNA1(7), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(2), CCNH(1), CDC14A(5), CDC16(3), CDC20(1), CDC23(2), CDC25A(1), CDC25B(1), CDC25C(2), CDC27(1), CDC6(1), CDC7(1), CDK2(2), CDKN1A(1), CDKN2A(3), CDKN2C(1), CHEK2(1), CREBBP(5), CUL1(3), E2F1(1), EP300(11), ESPL1(7), FZR1(3), GSK3B(3), HDAC1(2), MAD2L1(1), MCM2(6), MCM5(2), MCM6(3), MCM7(5), PCNA(2), PRKDC(10), RB1(2), RBL2(2), SKP2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMC1A(2), SMC1B(2), TGFB2(1), WEE1(1), YWHAB(1)	89215052	168	116	157	38	8	20	19	55	65	1	0.161	1.000	1.000
542	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), AKAP1(2), AKAP10(1), AKAP11(2), AKAP12(5), AKAP2(2), AKAP3(1), AKAP4(2), AKAP6(4), AKAP7(1), AKAP8(2), AKAP9(18), ARHGEF1(2), CALM2(1), CHMP1B(2), GNA12(1), GNA13(4), GNA15(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB1(2), GNB3(2), GNB5(2), GNG3(1), HRAS(1), IL18BP(1), ITPR1(4), KCNJ3(3), KRAS(1), PDE1A(1), PDE1B(5), PDE1C(1), PDE4A(2), PDE4B(1), PDE4D(1), PDE8A(2), PDE8B(1), PLCB3(2), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKD3(3), SLC9A1(2), USP5(2)	76159464	161	115	155	37	16	21	5	66	52	1	0.232	1.000	1.000
543	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(2), CACNA1A(5), CRHR1(1), GNA12(1), GNA13(4), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(5), GNAZ(1), GRIA1(6), GRIA2(3), GRIA3(2), GRID2(6), GRM1(4), GRM5(7), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HRAS(1), IGF1R(1), ITPR1(4), ITPR2(9), ITPR3(4), KRAS(1), MAPK3(1), NOS1(9), NOS3(2), NPR1(4), NPR2(4), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), PRKCA(2), PRKCG(2), PRKG1(3), PRKG2(2), RAF1(1), RYR1(13)	72272749	152	115	150	44	24	16	9	61	41	1	0.548	1.000	1.000
544	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(1), ACTN2(3), ACTN4(2), ARHGAP5(4), BCAR1(3), CDC42(1), CDH5(3), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(1), CLDN4(2), CLDN6(1), CLDN7(1), CTNNA1(4), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(5), CXCR4(1), ESAM(1), EZR(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(1), ITGA4(2), ITGAL(5), ITGAM(5), ITGB1(4), ITGB2(1), ITK(1), JAM3(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(8), MMP2(6), MMP9(1), MSN(2), MYL2(1), MYL7(1), MYL9(1), NCF1(1), NCF2(1), NOX1(6), NOX3(4), OCLN(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCG(2), PTK2(1), PTK2B(3), PTPN11(1), PXN(1), RAP1A(1), RAPGEF3(1), RAPGEF4(1), ROCK1(4), ROCK2(2), SIPA1(1), VAV1(3), VAV2(4), VCAM1(3), VCL(2)	79737708	156	111	148	49	16	20	18	53	49	0	0.757	1.000	1.000
545	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR6(1), CCR9(1), CHML(1), CHRM2(3), CHRM3(2), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(2), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(3), F2RL1(1), F2RL2(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(1), GPR174(2), GPR35(2), GPR37(1), GPR37L1(1), GPR4(1), GPR50(1), GPR63(1), GPR83(1), GPR85(2), GPR87(1), GRPR(1), HRH2(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), MAS1(1), MC1R(2), MC3R(2), MC4R(1), MC5R(1), MTNR1B(1), NMUR2(4), NTSR1(1), OPN1SW(2), OPRD1(2), OPRL1(1), OPRM1(3), OR12D3(1), OR1C1(1), OR1F1(1), OR5V1(2), OR7A5(1), OR7C1(2), OR8B8(2), P2RY1(1), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), PTAFR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), RHO(1), SSTR1(1), SSTR3(1), SSTR4(1), TBXA2R(2), TRHR(2)	74811985	139	110	137	46	23	19	15	55	27	0	0.496	1.000	1.000
546	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	78	AGL(4), AMY2A(1), AMY2B(1), ASCC3(5), ATP13A2(4), DDX18(3), DDX23(2), DDX4(3), DDX50(5), DDX52(1), DDX54(1), DDX55(2), DHX58(1), ENPP3(1), EP400(8), ERCC2(1), ERCC3(1), G6PC(3), GAA(1), GANC(2), GBA(2), GUSB(5), GYS1(3), GYS2(1), HK1(5), IFIH1(1), MGAM(5), MOV10L1(5), PYGB(2), PYGL(1), PYGM(3), RAD54L(2), RUVBL2(2), SETX(7), SI(6), SMARCA2(5), SMARCA5(1), UGP2(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), UXS1(1)	80681061	136	105	134	47	7	22	18	42	47	0	0.868	1.000	1.000
547	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	105	A4GNT(2), ALG1(1), ALG10(3), ALG10B(6), ALG11(3), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG6(2), ALG8(1), B3GNT1(1), B3GNT2(3), B3GNT6(1), B3GNT7(1), B4GALT3(2), B4GALT4(2), B4GALT5(1), CHST1(2), CHST11(1), CHST12(2), CHST14(1), CHST2(1), CHST4(1), CHST7(1), DPAGT1(5), EXT1(3), EXT2(1), EXTL1(1), EXTL3(3), FUT11(1), GALNT1(1), GALNT10(5), GALNT11(2), GALNT13(3), GALNT14(1), GALNT2(1), GALNT4(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST5(1), HS6ST1(1), HS6ST2(1), MAN1A1(2), MAN1A2(1), MAN2A1(3), MGAT4A(3), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(2), NDST2(3), NDST4(5), OGT(4), RPN1(2), RPN2(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1), ST6GALNAC1(2), STT3B(3), WBSCR17(3), XYLT1(2), XYLT2(2)	68666898	146	105	140	41	5	26	13	50	52	0	0.645	1.000	1.000
548	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	124	BID(1), BRAF(2), CD48(1), FAS(1), FYN(2), GRB2(2), HCST(1), HLA-B(1), HLA-C(2), HLA-E(2), HRAS(1), ICAM1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNGR1(2), IFNGR2(2), ITGAL(5), ITGB2(1), KIR2DL3(1), KIR3DL1(3), KLRC1(2), KLRC2(3), KLRC3(1), KRAS(1), LCP2(1), MAPK3(1), MICA(1), MICB(2), NCR1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PAK1(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PPP3CA(2), PPP3CC(3), PRF1(1), PRKCA(2), PRKCG(2), PTK2B(3), PTPN11(1), PTPN6(3), RAC3(1), RAF1(1), SH2D1B(1), SH3BP2(2), SHC1(3), SHC2(1), SOS1(5), SOS2(3), SYK(1), TNFRSF10C(1), ULBP2(1), VAV1(3), VAV2(4)	70790098	142	105	137	36	8	24	16	51	42	1	0.474	1.000	1.000
549	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(6), ABCA10(4), ABCA12(7), ABCA13(17), ABCA2(2), ABCA3(3), ABCA4(7), ABCA5(5), ABCA6(3), ABCA7(7), ABCA8(4), ABCA9(3), ABCB1(4), ABCB11(3), ABCB4(5), ABCB5(3), ABCB6(1), ABCB8(1), ABCC10(4), ABCC11(5), ABCC12(2), ABCC2(1), ABCC3(7), ABCC4(5), ABCC5(2), ABCC6(5), ABCC8(4), ABCC9(3), ABCD2(1), ABCD3(2), ABCD4(3), ABCG1(1), ABCG4(5), ABCG5(2), ABCG8(3), CFTR(4), TAP2(1)	75403065	145	104	137	37	5	24	18	59	38	1	0.250	1.000	1.000
550	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(4), ACTN1(1), ACTR2(1), AKT1(1), AKT2(3), AKT3(1), ARHGEF6(2), ARHGEF7(4), BCAR1(3), BRAF(2), CDC42(1), CDKN2A(3), CSE1L(2), DOCK1(1), EPHB2(2), FYN(2), GRB2(2), GRB7(2), ILK(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), MAP2K7(1), MAP3K11(1), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PIK3CB(3), PLCG1(2), PLCG2(2), PTK2(1), RAF1(1), RALA(2), RHO(1), ROCK1(4), ROCK2(2), SHC1(3), SOS1(5), SOS2(3), SRC(1), TLN1(6), TLN2(8), ZYX(1)	77961831	146	101	140	38	7	25	16	49	48	1	0.426	1.000	1.000
551	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM2(1), CDS2(1), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), FN3K(1), IMPA2(3), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5D(2), INPP5E(1), INPPL1(2), ITPK1(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), OCRL(2), PI4KA(9), PI4KB(3), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3C3(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PRKCA(2), PRKCG(2), PTPMT1(1), SYNJ1(5), SYNJ2(5)	80459713	139	99	134	43	13	22	11	48	44	1	0.744	1.000	1.000
552	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(1), CDC40(1), CLK2(2), CLK3(1), CLK4(3), COL2A1(5), CPSF1(3), CPSF2(2), CPSF3(4), CPSF4(2), CSTF2T(1), CSTF3(4), DDX1(1), DDX20(4), DHX15(2), DHX16(1), DHX8(2), DHX9(3), DICER1(3), FUS(5), GIPC1(1), NONO(2), NUDT21(1), NXF1(1), PAPOLA(2), POLR2A(8), PPM1G(1), PRPF3(2), PRPF4B(3), PRPF8(11), PSKH1(1), PTBP1(1), PTBP2(1), RBM17(1), RBM5(1), RNMT(1), SF3A1(1), SF3A3(1), SF3B1(7), SF3B2(2), SNRPB(1), SNRPN(2), SPOP(1), SRPK2(2), SRRM1(2), SUPT5H(4), TXNL4A(1), U2AF2(2), XRN2(2)	68667201	116	96	113	30	8	27	9	40	31	1	0.373	1.000	1.000
553	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1(1), ACVR1B(3), AKT1(1), BMPR2(5), CDKL1(1), CDS2(1), CLK1(4), CLK2(2), CLK4(3), COL4A3BP(2), CSNK2A2(1), CSNK2B(1), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKB(2), MAP3K10(3), MOS(1), NEK1(3), NEK3(3), OCRL(2), PAK4(2), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3CB(3), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCG1(2), PLCG2(2), PLK3(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKG1(3), RAF1(1), RPS6KA4(1), RPS6KB1(2)	72203765	128	94	126	32	9	19	6	45	49	0	0.450	1.000	1.000
554	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(4), ATM(15), BUB1B(1), BUB3(1), CCNA1(7), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(2), CCNH(1), CDAN1(4), CDC14A(5), CDC20(1), CDC25A(1), CDC25B(1), CDC25C(2), CDC6(1), CDC7(1), CDH1(1), CDK2(2), CDKN1A(1), CDKN2A(3), CHEK2(1), DTX4(4), E2F1(1), E2F5(1), EP300(11), ESPL1(7), GSK3B(3), HDAC1(2), HDAC4(1), HDAC6(2), MAD2L1(1), MCM2(6), MCM5(2), MCM6(3), MCM7(5), PCNA(2), PRKDC(10), PTPRA(3), RB1(2), SKP2(1), SMAD4(1), TBC1D8(1), WEE1(1)	72153300	136	92	127	35	8	17	20	43	47	1	0.262	1.000	1.000
555	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(1), ACVR1B(3), ACVR1C(3), ACVR2A(1), ACVR2B(1), BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMP7(3), BMP8B(1), BMPR1B(1), BMPR2(5), CHRD(3), CREBBP(5), CUL1(3), DCN(3), E2F5(1), EP300(11), GDF5(1), GDF6(1), INHBA(2), INHBB(1), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(3), MAPK3(1), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), RBL2(2), ROCK1(4), ROCK2(2), RPS6KB1(2), RPS6KB2(2), SMAD2(2), SMAD3(1), SMAD4(1), SMAD5(1), SMAD9(1), SMURF1(1), SMURF2(2), SP1(2), TGFB2(1), TGFBR2(1), THBS2(1), THBS3(4), THBS4(1), ZFYVE16(1), ZFYVE9(5)	61197131	112	92	109	27	9	8	13	46	36	0	0.365	1.000	1.000
556	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(4), ASH2L(2), CTCFL(2), DOT1L(2), EHMT1(3), EHMT2(3), EZH1(1), EZH2(4), FBXO11(2), HCFC1(6), HSF4(3), JMJD4(1), JMJD6(4), KDM6A(3), MEN1(1), NSD1(8), OGT(4), PAXIP1(1), PRDM2(1), PRDM6(1), PRDM7(2), PRDM9(3), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), RBBP5(3), SATB1(2), SETD1A(4), SETD7(1), SETDB1(4), SETMAR(2), SMYD3(2), SUV39H2(4), SUV420H1(2), SUZ12(5), WHSC1(4), WHSC1L1(5)	75908148	105	82	104	28	7	18	10	34	36	0	0.486	1.000	1.000
557	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL1(2), ACSL4(1), ACSL5(1), ACSL6(4), ANGPTL4(2), APOA5(2), AQP7(3), CPT1A(1), CPT1C(4), CPT2(1), CYP27A1(1), CYP4A11(4), CYP8B1(3), DBI(1), EHHADH(5), FABP1(3), FABP3(1), FADS2(2), GK(1), GK2(1), HMGCS2(1), ILK(4), LPL(2), ME1(1), NR1H3(2), PCK1(4), PCK2(1), PLTP(2), PPARD(1), PPARG(2), RXRB(4), RXRG(2), SCP2(2), SLC27A1(2), SLC27A2(1), SLC27A5(2), SLC27A6(6), SORBS1(1), UBC(3), UCP1(1)	41198276	92	73	85	28	6	10	14	31	31	0	0.779	1.000	1.000
558	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(1), IMPA2(3), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5E(1), INPPL1(2), IPMK(1), ITPK1(1), ITPKB(2), MINPP1(1), MIOX(2), OCRL(2), PI4KA(9), PI4KB(3), PIK3C3(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PTPMT1(1), SYNJ1(5), SYNJ2(5)	46425421	88	70	84	28	7	11	7	30	32	1	0.891	1.000	1.000
559	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT1(1), AKT2(3), AKT3(1), CASP9(1), CDC42(1), HRAS(1), KDR(5), KRAS(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NOS3(2), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG1(2), PLCG2(2), PPP3CA(2), PPP3CC(3), PRKCA(2), PRKCG(2), PTGS2(4), PTK2(1), PXN(1), RAC3(1), RAF1(1), SH2D2A(1), SHC2(1), SPHK2(1), SRC(1)	44874462	86	69	82	29	6	13	8	37	22	0	0.801	1.000	1.000
560	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT1(1), AKT2(3), AKT3(1), FYN(2), GAB2(1), GRB2(2), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(1), LCP2(1), MAP2K3(2), MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MS4A2(1), PDK1(1), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG1(2), PLCG2(2), PRKCA(2), PRKCD(3), PRKCE(2), RAC3(1), RAF1(1), SOS1(5), SOS2(3), SYK(1), VAV1(3), VAV2(4)	45962800	77	69	75	26	7	15	12	29	14	0	0.633	1.000	1.000
561	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(11), B3GALT4(1), CDR1(2), DGKI(1), IL6ST(3), PIGK(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL23(1), RPL27(1), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL32(1), RPL34(1), RPL38(1), RPL3L(2), RPL4(2), RPL5(3), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(1), RPS19(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), RPS9(1), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(3)	32979340	74	67	74	19	3	7	13	30	21	0	0.538	1.000	1.000
562	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(3), APAF1(2), ARHGDIB(1), BAG4(1), BID(1), BIRC2(2), BIRC3(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), DAXX(5), DFFB(1), GSN(2), LMNB1(3), MAP2K7(1), MAP3K1(5), MAP3K5(5), NFKB1(1), NUMA1(3), PAK2(2), PRKCD(3), PRKDC(10), PSEN2(2), PTK2(1), RASA1(3), RB1(2), RELA(5), RIPK1(1), SPTAN1(6), TNFRSF1A(1), TRADD(2), TRAF2(1)	45462088	83	63	80	19	3	17	10	28	24	1	0.160	1.000	1.000
563	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), ASCC3(5), ATP13A2(4), DDX18(3), DDX23(2), DDX4(3), DDX50(5), DDX52(1), DDX54(1), DDX55(2), DHX58(1), EP400(8), ERCC2(1), ERCC3(1), FPGS(2), IFIH1(1), MOV10L1(5), QDPR(1), RAD54L(2), RUVBL2(2), SETX(7), SMARCA2(5), SMARCA5(1)	40371745	73	63	72	22	2	16	9	21	25	0	0.502	1.000	1.000
564	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(4), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), CDC42(1), CHUK(1), CSK(3), EGFR(9), F11R(1), GIT1(1), IKBKB(1), JAM3(1), JUN(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(6), NFKB1(1), NFKB2(1), NOD1(1), PAK1(2), PLCG1(2), PLCG2(2), PTPN11(1), PTPRZ1(9), RELA(5), SRC(1), TJP1(2)	45905289	81	62	74	20	6	12	9	31	22	1	0.547	1.000	1.000
565	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(5), ATP4A(5), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), COX10(2), COX15(1), COX17(1), COX6B2(1), CYC1(1), NDUFA1(1), NDUFA10(1), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFB2(1), NDUFB6(1), NDUFC1(2), NDUFS1(5), NDUFS2(1), NDUFS3(2), NDUFS5(1), NDUFS6(1), NDUFS8(1), NDUFV1(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SDHD(1), UQCRC1(1), UQCRC2(1), UQCRFS1(1)	36695426	71	61	70	22	5	10	9	29	18	0	0.702	1.000	1.000
566	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(9), EEF1A2(1), EEF1G(1), EEF2K(1), EIF2AK1(1), EIF2AK2(4), EIF2AK3(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(2), EIF2S2(2), EIF4A2(3), EIF4E(1), EIF4G1(3), EIF4G3(3), EIF5(2), EIF5A(2), ETF1(2), PABPC1(9), PABPC3(7), PAIP1(3), SLC35A4(2)	28841964	63	56	63	23	7	11	6	23	16	0	0.831	1.000	1.000
567	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(7), AXIN1(2), CCND2(1), CTNNB1(1), DVL1(1), DVL2(1), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD5(1), GSK3B(3), JUN(2), LDLR(1), MAPK10(1), MAPK9(2), PAFAH1B1(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(1), PRKD1(3), SFRP4(2), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT5B(1), WNT7B(1)	37193972	62	56	59	21	5	13	6	20	18	0	0.716	1.000	1.000
568	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AKR1C1(1), ALDH3B1(3), ALDH3B2(2), CYP1A1(1), CYP1A2(3), CYP1B1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP3A7(1), DHDH(2), EPHX1(4), GSTA3(1), GSTA4(1), GSTA5(1), GSTM1(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3)	37411647	64	52	62	17	7	7	9	24	17	0	0.484	1.000	1.000
569	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(4), AMY2A(1), AMY2B(1), ENPP3(1), G6PC(3), GAA(1), GUSB(5), GYS1(3), GYS2(1), HK1(5), MGAM(5), PYGB(2), PYGL(1), PYGM(3), RNPC3(1), SI(6), UCHL3(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2), UXS1(1)	37071428	60	51	59	20	5	9	8	19	19	0	0.748	1.000	1.000
570	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(2), CARS(6), CARS2(3), DARS(1), DARS2(1), EPRS(2), FARSA(1), HARS(1), HARS2(1), IARS(4), IARS2(2), LARS(3), LARS2(2), MARS(2), MARS2(3), NARS2(4), PARS2(3), QARS(1), RARS(2), SARS(2), TARS(5), TARS2(5), VARS(2), VARS2(2), WARS(1), WARS2(1), YARS(1)	34829011	65	50	61	16	1	11	7	27	19	0	0.458	1.000	1.000
571	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(1), F12(3), F13B(2), F2(2), F5(7), F7(1), F8(5), F9(2), FGA(2), FGB(1), FGG(5), LPA(6), PLAT(4), PLG(5), SERPINF2(2), VWF(11)	22827589	59	49	55	19	4	3	11	20	19	2	0.681	1.000	1.000
572	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	42	AGMAT(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), ALDH4A1(1), AOC2(3), AOC3(1), ARG1(1), ASL(4), CPS1(4), DAO(1), GATM(1), GOT1(3), GOT2(2), MAOA(1), NOS1(9), NOS3(2), OAT(1), ODC1(2), OTC(1), P4HA1(3), P4HA2(1), PYCR1(1), RARS(2), SMS(2)	27935860	52	48	52	18	3	5	11	17	16	0	0.801	1.000	1.000
573	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(1), CDC7(1), CDK2(2), CDT1(1), DIAPH2(2), MCM10(2), MCM2(6), MCM5(2), MCM6(3), MCM7(5), PCNA(2), POLD1(6), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(4), RFC2(1), RFC4(1), RFC5(1), RPA1(2), RPA2(1), RPA3(1), RPA4(1), RPS27A(1), UBB(1), UBC(3)	30815669	58	48	56	16	5	7	6	22	18	0	0.600	1.000	1.000
574	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(1), CDS2(1), CHAT(4), CHKB(2), CHPT1(2), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(1), ETNK1(2), GPAM(2), LCAT(1), LYPLA1(1), PCYT1A(1), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(5), PNPLA3(2), PPAP2B(1), PPAP2C(2), PTDSS1(2), SH3GLB1(2)	42731591	58	48	54	15	8	7	4	17	22	0	0.511	1.000	1.000
575	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTB(1), ACTG1(3), ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(1), EZR(1), FYN(2), HCLS1(1), ITGB1(4), LY96(1), NCK1(1), NCL(3), OCLN(2), PRKCA(2), ROCK1(4), ROCK2(2), TLR4(2), TLR5(2), TUBA1A(2), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2)	32390928	57	47	56	22	3	13	9	17	15	0	0.903	1.000	1.000
576	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTB(1), ACTG1(3), ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(1), EZR(1), FYN(2), HCLS1(1), ITGB1(4), LY96(1), NCK1(1), NCL(3), OCLN(2), PRKCA(2), ROCK1(4), ROCK2(2), TLR4(2), TLR5(2), TUBA1A(2), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2)	32390928	57	47	56	22	3	13	9	17	15	0	0.903	1.000	1.000
577	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK14(1), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), RAF1(1), SHC1(3), SOS1(5), SYK(1), SYT1(1), VAV1(3)	24547456	53	46	50	19	6	8	4	16	19	0	0.876	1.000	1.000
578	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	52	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(2), AOC2(3), AOC3(1), AOX1(7), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(3), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2J2(3), CYP3A7(1), CYP4B1(3), DDC(2), ECHS1(2), EHHADH(5), HAAO(1), HADHA(2), MAOA(1), TPH1(1), WARS(1), WARS2(1)	34678570	55	46	54	21	6	10	7	20	12	0	0.798	1.000	1.000
579	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), ATP8A1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR6(1), CX3CR1(1), CXCR4(1), CXCR6(1), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GRPR(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NTSR1(1), OPRD1(2), OPRL1(1), OPRM1(3), SSTR1(1), SSTR3(1), SSTR4(1), TACR1(1), TACR3(2), TRHR(2), TSHR(2)	32739361	55	44	55	18	13	7	6	19	10	0	0.437	1.000	1.000
580	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(5), CREBBP(5), EP300(11), ERCC3(1), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC6(2), NCOR2(6), NRIP1(4), PELP1(1), POLR2A(8), TBP(1)	30162873	51	43	48	16	2	6	8	17	18	0	0.643	1.000	1.000
581	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(1), CBL(2), CFLAR(1), E2F1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), IRS1(4), JAK1(4), JAK3(3), MAPK3(1), PIK3R1(2), PTPN6(3), RAF1(1), RPS6KB1(2), SHC1(3), SOCS3(1), SOS1(5), STAT5A(2), STAT5B(2), SYK(1)	21477159	47	43	46	15	6	9	6	11	15	0	0.622	1.000	1.000
582	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(2), ALOX15B(2), ALOX5(2), CBR1(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2J2(3), CYP2U1(1), CYP4A11(4), CYP4F2(2), DHRS4(3), EPHX2(1), GGT1(2), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3)	25276434	48	42	46	14	4	6	12	12	13	1	0.483	1.000	1.000
583	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(1), GALNT1(1), GALNT10(5), GALNT11(2), GALNT13(3), GALNT14(1), GALNT2(1), GALNT4(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(4), ST3GAL1(1), ST6GALNAC1(2), WBSCR17(3)	21376454	43	41	40	18	1	5	6	19	12	0	0.962	1.000	1.000
584	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPS(1), CDS2(1), CHAT(4), CHKB(2), CLC(2), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), ETNK1(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(1), PISD(1), PLA2G4A(1), PLA2G6(2), PLCB2(2), PLCG1(2), PLCG2(2), PPAP2B(1), PPAP2C(2)	32534496	46	39	43	17	6	9	2	11	18	0	0.803	1.000	1.000
585	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	DOCK1(1), ELK1(1), FOS(1), GAB1(1), GRB2(2), HGF(1), HRAS(1), ITGA1(5), ITGB1(4), JUN(2), MAP4K1(1), MAPK3(1), MET(6), PAK1(2), PIK3R1(2), PTK2(1), PTK2B(3), PTPN11(1), PXN(1), RAF1(1), RAP1A(1), RASA1(3), SOS1(5), SRC(1), STAT3(3)	27699494	51	39	49	17	4	12	2	18	15	0	0.859	1.000	1.000
586	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(4), AR(1), ESR2(2), NR1D2(1), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2F2(2), NR4A2(1), NR5A2(2), PGR(2), PPARD(1), PPARG(2), RARA(4), RARB(2), RORA(2), RORC(1), RXRB(4), RXRG(2), THRA(1), VDR(1)	26236564	40	38	40	15	6	3	9	13	9	0	0.810	1.000	1.000
587	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(1), EIF4A2(3), EIF4E(1), EIF4G1(3), EIF4G2(3), EIF4G3(3), GHR(1), IRS1(4), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(9), PDK2(2), PIK3R1(2), PRKCA(2), RPS6KB1(2)	16318161	40	37	40	13	6	9	3	15	7	0	0.627	1.000	1.000
588	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(3), ACTG2(1), ADCY3(3), ADCY9(4), ARF1(1), ARF3(1), ARF6(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1D(1), ATP6V1G1(1), GNAS(5), PLCG1(2), PLCG2(2), PRKCA(2), SEC61B(1), TRIM23(3)	24292078	42	37	41	14	1	6	5	16	14	0	0.881	1.000	1.000
589	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	22	GHR(1), GRB2(2), HRAS(1), INSR(4), IRS1(4), JAK2(5), MAPK3(1), PIK3R1(2), PLCG1(2), PRKCA(2), PTPN6(3), RAF1(1), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2)	18883942	40	35	36	13	4	6	4	13	13	0	0.804	1.000	1.000
590	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(3), JAK1(4), JAK2(5), JAK3(3), JUN(2), MAPK3(1), PTPN11(1), RAF1(1), SHC1(3), SOS1(5), STAT3(3)	15363821	38	35	38	13	3	4	6	15	10	0	0.860	1.000	1.000
591	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM2(1), GRB2(2), HRAS(1), JUN(2), MAP2K3(2), MAP3K1(5), MAPK14(1), MAPK3(1), PAK1(2), PLCG1(2), PRKCA(2), PTK2B(3), RAF1(1), SHC1(3), SOS1(5), SRC(1), SYT1(1)	18578940	38	34	37	12	3	8	1	15	11	0	0.813	1.000	1.000
592	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), G6PC(3), GAA(1), GALK1(1), GALK2(1), GALT(3), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(2), MGAM(5), PFKM(3), PFKP(2)	21050291	36	33	35	13	3	5	4	9	15	0	0.843	1.000	1.000
593	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKB(2), MIOX(2), OCRL(2), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3CB(3), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCG1(2), PLCG2(2)	28177340	40	33	39	15	1	3	2	18	16	0	0.972	1.000	1.000
594	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(1), AKT1(1), DGKA(2), GCA(2), ITGA9(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(3), PDE3B(1), PIK3C2G(2), PIK3CD(1), PIK3R1(2)	30707028	39	32	39	13	6	7	4	13	9	0	0.546	1.000	1.000
595	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(3), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2J2(3), CYP3A7(1), CYP4B1(3)	18605266	35	31	35	11	6	8	1	14	6	0	0.472	1.000	1.000
596	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), JAK1(4), JAK3(3), JUN(2), MAPK3(1), RAF1(1), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2), SYK(1)	15080632	33	31	32	11	4	5	4	11	9	0	0.764	1.000	1.000
597	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(1), APAF1(2), ATM(15), BID(1), CASP7(1), CASP9(1), PRKCA(2), PTK2(1), PXN(1), STAT1(3), TLN1(6)	17564613	34	30	34	10	2	5	2	12	13	0	0.703	1.000	1.000
598	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	AGMAT(1), ALDH18A1(2), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOC2(3), AOC3(1), ARG1(1), ASL(4), ASS1(2), CPS1(4), GATM(1), MAOA(1), ODC1(2), OTC(1), SAT1(1), SMS(2)	18475885	30	30	30	10	0	5	6	10	9	0	0.726	1.000	1.000
599	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22RA1(1), IL22RA2(1), JAK1(4), JAK2(5), JAK3(3), SOCS3(1), STAT1(3), STAT3(3), STAT5A(2), STAT5B(2), TYK2(6)	11937463	31	30	29	12	1	0	5	12	13	0	0.977	1.000	1.000
600	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(4), ADRB2(2), CHRM2(3), CHRM3(2), CHRM5(2), DRD1(1), DRD2(1), DRD3(2), DRD5(1), HRH2(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2)	15949244	33	30	31	15	5	3	2	14	9	0	0.908	1.000	1.000
601	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	DLG4(1), EPHB2(2), F2(2), F2RL1(1), F2RL2(1), JUN(2), MAP2K5(1), MAPK7(1), PLD1(2), PLD2(5), PLD3(3), PTK2(1), RAF1(1), SRC(1), TEC(5), VAV1(3)	16983336	32	29	30	12	4	1	3	15	9	0	0.934	1.000	1.000
602	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CFL1(1), GNAS(5), GNB1(2), HRAS(1), LIMK1(4), MAPK3(1), MYL2(1), NOX1(6), PIK3C2G(2), PLCB1(1), PPP1R12B(1), PRKCA(2), PTK2(1), RAF1(1), ROCK2(2)	16827317	31	28	27	11	1	2	1	15	12	0	0.975	1.000	1.000
603	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(2), ANXA4(2), ANXA6(2), CYP11A1(1), EDNRB(3), HPGD(1), PLA2G4A(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), PTGS1(2), PTGS2(4), TBXAS1(3)	13322619	28	28	28	14	2	4	4	10	7	1	0.953	1.000	1.000
604	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(1), ACTN2(3), CAPN1(1), ITGA1(5), ITGB1(4), ITGB3(1), PTK2(1), PXN(1), SPTAN1(6), SRC(1), TLN1(6)	18685380	30	28	29	12	2	3	1	12	12	0	0.954	1.000	1.000
605	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CDKN1A(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1)	13047876	31	27	28	11	2	5	2	7	15	0	0.901	1.000	1.000
606	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1R(1), IRS1(4), JUN(2), MAPK3(1), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(3), SHC1(3), SOS1(5)	14318494	28	26	28	10	6	8	1	10	3	0	0.647	1.000	1.000
607	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), LCAT(1), LDLR(1), LIPC(1), LPL(2), LRP1(11), SCARB1(1), SOAT1(4)	17613083	27	26	25	10	2	5	3	7	10	0	0.758	1.000	1.000
608	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	24	AKR1B1(3), ALDOA(1), ALDOB(3), FPGT(1), GMDS(1), GMPPA(1), GMPPB(1), HK1(5), KHK(3), MPI(1), PFKFB3(1), PFKM(3), PFKP(2), TPI1(1)	15263040	27	25	27	12	4	2	4	5	12	0	0.945	1.000	1.000
609	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), GNAI1(1), GNB1(2), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), PLA2G4A(1), PLCB1(1), PRKCA(2), PTGS1(2), PTK2(1), RAF1(1), SRC(1), SYK(1), TBXAS1(3)	16063605	29	25	28	15	2	4	3	8	11	1	0.984	1.000	1.000
610	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(3), CXCR4(1), GNAI1(1), GNB1(2), HRAS(1), MAPK3(1), NFKB1(1), PIK3C2G(2), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(1), PTK2B(3), PXN(1), RAF1(1), RELA(5)	16952399	29	24	25	15	1	6	1	11	9	1	0.989	1.000	1.000
611	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(3), BCAR1(3), CSK(3), CTNNA1(4), CTNNA2(4), CTNNB1(1), PTK2(1), PXN(1), SRC(1), VCL(2)	12436358	24	23	24	13	3	3	3	12	3	0	0.973	1.000	1.000
612	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(2), AKT1(1), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(1), ITGB3(1), MAPK3(1), PDGFRA(5), PIK3R1(2), PLCB1(1), PRKCA(2), PTK2(1), SMPD2(2), SRC(1)	16565015	24	22	24	14	2	6	2	8	6	0	0.983	1.000	1.000
613	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(5), GALNT2(1), GALNT4(1), GALNT6(1), GALNT7(5), GALNT9(1), GCNT1(2), ST3GAL1(1), ST3GAL4(1), WBSCR17(3)	9626314	22	22	19	14	0	1	5	6	10	0	0.998	1.000	1.000
614	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(1), XYLT1(2), XYLT2(2)	3749783	6	6	6	5	1	3	0	2	0	0	0.859	1.000	1.000
615	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(1), XYLT1(2), XYLT2(2)	3749783	6	6	6	5	1	3	0	2	0	0	0.859	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		341605	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
