rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A1(1), EIF4A2(1), EIF4B(2), EIF4EBP1(1), EIF4G1(1), EIF4G2(1), EIF4G3(4), PIK3CA(2), PIK3R1(2), PTEN(5), TSC1(2), TSC2(4)	6716562	27	24	27	2	2	6	4	6	9	0	0.0233	0.0101	1.000
2	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(2), ADORA3(1), P2RY1(2), P2RY2(1), P2RY6(2)	1424191	8	8	8	0	1	1	2	4	0	0	0.0940	0.0103	1.000
3	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(2), ERBB4(3), NRG2(1), NRG3(3)	2177146	9	9	9	0	2	1	1	4	1	0	0.0853	0.0215	1.000
4	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(1)	433960	3	3	3	1	1	0	1	1	0	0	0.766	0.0235	1.000
5	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(2), IDH2(1), MDH1(1), OGDH(5), SDHA(2), SUCLA2(1)	2277788	12	11	12	2	0	3	0	4	5	0	0.293	0.0286	1.000
6	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(2), AKT3(2), PIK3CA(2), PIK3CD(1), PTEN(5), RBL2(2), SOS1(3)	4925268	18	16	18	1	2	3	3	3	7	0	0.0295	0.0315	1.000
7	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(2), GCLC(3), GGT1(1), GSTA1(1), GSTA2(1), GSTK1(1), GSTM1(1), GSTM4(1), GSTP1(2), GSTT1(2), IDH2(1), OPLAH(3)	5431281	19	17	19	0	2	2	5	6	4	0	0.00487	0.0380	1.000
8	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB1A(1), RAB3A(1), RAB6A(1)	1030751	5	5	5	1	0	1	1	2	1	0	0.685	0.0404	1.000
9	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(3), AGT(3), AGTR2(1), KNG1(2), NOS3(1)	2443240	10	10	10	1	1	1	1	6	1	0	0.230	0.0420	1.000
10	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA11(2), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB7(1), NDUFS1(1), NDUFV1(1)	1698697	9	9	8	2	0	0	1	2	6	0	0.750	0.0423	1.000
11	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(1), DPYS(2), ENPP1(4), ENPP3(1), PANK2(1), PANK3(2), PPCS(1)	3373705	13	12	13	1	2	0	0	6	5	0	0.281	0.0439	1.000
12	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), CAMP(1), DAG1(3), ITPKA(1), ITPKB(1)	1465809	7	6	7	1	1	0	2	0	4	0	0.693	0.0486	1.000
13	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	122038	1	1	1	0	0	0	0	0	1	0	1.000	0.0661	1.000
14	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGAL(2), ITGAM(3), ITGB2(1), SELE(1), SELL(1)	2555223	9	9	9	0	2	2	0	4	1	0	0.0716	0.0677	1.000
15	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	HMOX1(1), IL10RA(4), JAK1(2), STAT1(1), STAT5A(1), TNF(1)	2954387	10	10	10	1	2	0	0	6	2	0	0.458	0.0708	1.000
16	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), HADHA(2)	1314125	5	5	5	0	0	1	0	3	0	1	0.331	0.0734	1.000
17	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(1), ITGA4(1), ITGAL(2), ITGAM(3), ITGB1(2), ITGB2(1), SELE(1), SELL(1)	3887865	12	12	12	1	2	2	1	5	2	0	0.175	0.0765	1.000
18	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), EHHADH(1), HADHA(2)	1176952	5	5	5	1	0	0	1	3	1	0	0.524	0.0870	1.000
19	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(1), ITGA4(1), ITGAL(2), ITGB1(2), ITGB2(1), SELE(1), SELL(1)	2938159	9	9	9	1	1	2	1	3	2	0	0.317	0.0910	1.000
20	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(2), ALDH2(2), ALDH3A2(2), UGDH(1)	2074147	7	7	7	1	1	1	4	1	0	0	0.311	0.0918	1.000
21	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), GLS(2), OAT(1), PRODH(1)	1369163	5	5	5	0	0	0	2	1	2	0	0.407	0.103	1.000
22	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP6(2), ENPP1(4), ENPP3(1), FLAD1(1), MTMR2(2), MTMR6(1), PHPT1(1)	3638098	12	11	11	0	0	3	1	7	1	0	0.0552	0.130	1.000
23	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(2), GCLC(3), GGT1(1), GSTA1(1), GSTA2(1), GSTM1(1), GSTM4(1), GSTP1(2), GSTT1(2), IDH2(1)	4460585	15	13	15	0	1	1	4	6	3	0	0.0172	0.143	1.000
24	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLB(1), POLD1(1), POLG(2), POLG2(1), POLK(2), POLM(1), POLQ(5), PRIM1(1), PRIM2(2), REV1(2), REV3L(3), RFC5(2)	9891128	26	25	26	1	0	3	3	12	8	0	0.0364	0.143	1.000
25	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), HADHA(2)	2951017	9	9	9	1	1	1	3	4	0	0	0.202	0.145	1.000
26	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1B1(2), ALDH2(2), ALDH3A2(2)	1936281	6	6	6	0	1	1	3	1	0	0	0.124	0.149	1.000
27	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1B1(2), ALDH2(2), ALDH3A2(2)	1936281	6	6	6	0	1	1	3	1	0	0	0.124	0.149	1.000
28	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(2), IL5RA(2)	1287805	4	4	4	0	1	0	1	0	2	0	0.488	0.151	1.000
29	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(2), CYP51A1(2), DHCR24(1), GGCX(1), HSD17B7(1), IDI2(1), LSS(2), SQLE(1), TM7SF2(2)	4716092	13	12	13	0	2	3	1	5	2	0	0.0252	0.155	1.000
30	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), AMD1(2), AOC2(1), AOC3(1), ARG2(1), ASS1(1), CPS1(1), MAOA(1), MAOB(2), NAGS(1), SAT2(1)	7182804	22	20	22	2	3	2	5	7	5	0	0.0497	0.158	1.000
31	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), HLA-A(1), ICAM1(1), ITGAL(2), ITGB2(1)	2110199	6	6	6	1	1	1	0	3	0	1	0.433	0.170	1.000
32	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), CAD(3), CPS1(1), EPRS(2), GAD1(2), GAD2(1), GCLC(3), GFPT1(1), GLS(2), GLUL(2), GMPS(1), GPT(2), PPAT(1)	8035287	22	21	22	2	1	3	5	9	4	0	0.0593	0.178	1.000
33	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(2), MTMR6(1), PHPT1(1), TPK1(1)	1546101	5	5	5	0	0	2	1	2	0	0	0.211	0.181	1.000
34	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ADSL(2), AGXT(1), AGXT2(1), ASNS(1), CAD(3), CRAT(2), DARS(2), DDO(1), GAD1(2), GAD2(1), GPT(2), PC(5)	6335082	24	21	24	3	1	4	2	9	8	0	0.180	0.190	1.000
35	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(1), ACY3(2), ADSL(2), ADSSL1(1), AGXT(1), AGXT2(1), ASNS(1), ASS1(1), CAD(3), CRAT(2), DARS(2), DDO(1), DLD(2), GAD1(2), GAD2(1), GPT(2), NARS2(1), PC(5)	9199431	32	27	32	4	2	4	4	11	10	1	0.100	0.207	1.000
36	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLD(2), FH(2), IDH2(1), IDH3B(1), MDH1(1), OGDH(5), PC(5), PDHX(1), PDK4(1), SDHA(2), SDHD(1), SUCLA2(1), SUCLG1(1)	6898030	24	22	24	4	0	3	3	6	10	2	0.242	0.210	1.000
37	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(1), DPYS(2), ENPP1(4), ENPP3(1), ILVBL(1), PANK2(1), PANK3(2), PPCS(1)	4196180	14	13	14	2	2	0	1	6	5	0	0.434	0.213	1.000
38	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(2), CRY1(1), CSNK1E(3), PER1(1)	2088356	7	7	7	2	2	1	2	2	0	0	0.608	0.217	1.000
39	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), FH(2), IDH2(1), MDH1(1), SUCLA2(1)	2156731	6	6	6	1	0	0	0	2	4	0	0.485	0.223	1.000
40	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD86(2), CTLA4(2), ICOS(1), PIK3CA(2), PIK3R1(2), PTPN11(1)	3077017	10	10	10	2	0	3	1	4	2	0	0.537	0.226	1.000
41	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), GART(2), MTHFD1(3), MTHFD1L(1), MTHFD2(1), SHMT2(2), TYMS(1)	4324859	11	11	11	0	0	2	3	5	1	0	0.0529	0.228	1.000
42	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS2(2), SULT1E1(2)	1463166	4	4	4	1	0	2	1	1	0	0	0.512	0.231	1.000
43	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(1), EPHB1(2), ITGA1(3), ITGB1(2), LYN(1)	3791760	10	10	10	1	1	1	0	5	3	0	0.428	0.232	1.000
44	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), SNCAIP(2), UBE2L3(1)	1541971	5	5	5	1	0	1	0	3	1	0	0.510	0.234	1.000
45	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22RA1(2), JAK1(2), JAK2(1), JAK3(1), STAT1(1), STAT5A(1)	4510147	12	12	12	1	2	0	1	8	1	0	0.269	0.241	1.000
46	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(1)	1767040	5	5	5	1	0	0	3	2	0	0	0.622	0.251	1.000
47	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1), AOC3(1), CES1(1), ESD(1)	1453760	4	4	4	1	0	1	2	1	0	0	0.583	0.254	1.000
48	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), SDHA(2), SDHD(1)	1589838	4	4	4	1	0	2	2	0	0	0	0.461	0.254	1.000
49	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADHA(2), HSD17B4(1), MECR(3)	2059509	6	6	6	0	1	1	0	4	0	0	0.207	0.255	1.000
50	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), HAO1(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1)	3085025	8	8	8	1	0	1	2	2	3	0	0.418	0.256	1.000
51	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	HMGB1(3), HMGB2(2), TOP2A(1), TOP2B(4)	2327433	10	9	10	2	1	2	1	3	3	0	0.657	0.261	1.000
52	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), EHHADH(1), HADHA(2)	2028716	6	6	6	1	0	0	0	5	1	0	0.647	0.263	1.000
53	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1), SUCLA2(1)	517635	2	2	2	1	0	0	1	1	0	0	0.869	0.273	1.000
54	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAD(1), BAK1(1), BCL2L11(1), BID(1), CASP9(1), CES1(1)	2700022	7	7	7	1	1	1	3	0	2	0	0.310	0.277	1.000
55	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(2)	727593	2	2	2	0	0	0	1	0	1	0	0.747	0.285	1.000
56	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD1(2), GAD2(1), GGT1(1)	1404186	6	6	6	2	1	1	2	1	1	0	0.646	0.291	1.000
57	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CUL1(2), FBXW7(2)	2006615	5	5	5	0	1	1	2	0	1	0	0.203	0.292	1.000
58	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), HAO1(1), MDH1(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1)	3235278	8	8	8	1	0	1	2	2	3	0	0.421	0.298	1.000
59	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(6)	1993431	7	7	7	2	0	1	1	4	1	0	0.677	0.307	1.000
60	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(1), ACOX3(3), ELOVL6(1), FADS1(1), FASN(5), HADHA(2), PECR(1)	3608891	17	12	17	3	1	4	0	10	2	0	0.264	0.313	1.000
61	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP6(2), ALPI(1), ALPL(1), ALPP(1), ALPPL2(1), CMBL(1), CYP3A43(2), CYP3A7(1), PON2(2)	4383421	12	12	11	2	1	2	1	4	4	0	0.469	0.321	1.000
62	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(2)	2575227	6	6	6	1	1	1	0	2	2	0	0.401	0.323	1.000
63	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(1), GGT1(1), SHMT2(2)	1359590	4	4	4	0	0	0	1	3	0	0	0.402	0.331	1.000
64	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(3), ACACB(1), FASN(5), MCAT(2), OLAH(1), OXSM(2)	3947691	14	14	14	3	1	6	1	4	2	0	0.231	0.333	1.000
65	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(1)	397196	1	1	1	1	0	0	1	0	0	0	0.899	0.343	1.000
66	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), DLD(2), FH(2), IDH2(1), IDH3B(1), MDH1(1), PC(5), PCK1(1), SDHA(2), SUCLA2(1), SUCLG1(1)	4987243	18	17	18	5	0	2	2	4	8	2	0.576	0.352	1.000
67	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF3(1), CDKN2A(1), E2F2(1), TP53(4)	2036926	7	7	7	2	0	0	0	5	2	0	0.672	0.353	1.000
68	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(2)	2708738	6	6	6	1	1	1	0	2	2	0	0.404	0.360	1.000
69	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), HDC(1), HNMT(1), MAOA(1), MAOB(2), PRPS2(1)	5923857	16	15	16	2	3	3	3	6	1	0	0.108	0.368	1.000
70	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(2), CYP2A6(3), CYP2A7(1)	1928876	6	5	6	1	0	2	0	4	0	0	0.425	0.370	1.000
71	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1), SHMT2(2)	1024321	3	3	3	0	0	0	1	2	0	0	0.499	0.378	1.000
72	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(2), NOTCH1(5)	2284097	7	7	7	2	1	3	0	2	1	0	0.426	0.383	1.000
73	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), MTHFD2(1), POLB(1), POLD1(1), POLG(2), PRPS2(1)	3078420	8	8	8	0	0	1	1	4	2	0	0.211	0.386	1.000
74	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(1), HSD17B4(1), HSD17B7(1)	1950857	5	4	5	1	1	1	0	2	1	0	0.587	0.391	1.000
75	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	IDI2(1), SQLE(1)	1040548	2	2	2	0	1	1	0	0	0	0	0.440	0.404	1.000
76	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(1), HS3ST3A1(1), XYLT1(2)	1643817	4	4	4	0	1	0	0	1	2	0	0.364	0.407	1.000
77	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(1), HS3ST3A1(1), XYLT1(2)	1643817	4	4	4	0	1	0	0	1	2	0	0.364	0.407	1.000
78	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADL(3), ACADSB(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), AOC2(1), AOC3(1), DPYD(1), DPYS(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2)	7026885	21	21	21	4	1	5	3	7	4	1	0.229	0.409	1.000
79	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	RDH5(2)	933101	2	2	2	1	0	0	2	0	0	0	0.845	0.410	1.000
80	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(2)	1669583	4	4	4	0	0	1	1	2	0	0	0.321	0.414	1.000
81	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(2), IL6ST(3), JAK1(2), JAK2(1), JAK3(1), PTPN11(1), RAF1(2), SOS1(3)	5801557	15	14	15	2	2	2	1	6	4	0	0.201	0.422	1.000
82	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ALDH1B1(2), ALDH2(2), ALDH3A2(2), AOC2(1), AOC3(1), DPYD(1), DPYS(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HIBCH(1)	6539811	18	18	18	3	1	3	4	6	4	0	0.230	0.423	1.000
83	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(1)	782147	3	2	3	1	0	1	0	2	0	0	0.653	0.425	1.000
84	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(1)	539801	1	1	1	0	0	0	0	0	1	0	0.836	0.430	1.000
85	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(1), POLG(2), POLQ(5)	4056855	9	9	9	1	0	1	2	3	3	0	0.446	0.432	1.000
86	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS2(1), ILVBL(1), LARS(4), VARS(2), VARS2(3)	4501022	11	11	11	2	1	1	4	2	3	0	0.359	0.448	1.000
87	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNB1(1), PLCB1(1), TUB(1)	1721561	5	4	5	1	0	1	0	3	1	0	0.654	0.456	1.000
88	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), IGF1R(1), POLR2A(3), TEP1(4), TERF1(2), TERT(3), TNKS(2), TP53(4), XRCC5(1)	6810115	21	21	21	4	3	4	0	12	2	0	0.210	0.456	1.000
89	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(3), ACSL1(2), EHHADH(1), HADHA(2), PECR(1), SCP2(1)	4070942	10	10	10	2	0	3	0	5	1	1	0.426	0.456	1.000
90	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(2)	814873	2	2	2	0	0	0	0	1	1	0	0.524	0.461	1.000
91	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	TP53(4)	1711784	4	4	4	0	0	0	0	3	1	0	0.373	0.463	1.000
92	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	11	AHCY(4), CTH(1), DNMT1(2), DNMT3A(4), DNMT3B(2), MARS(1), MARS2(1), MAT1A(1), MAT2B(1)	4028568	17	16	17	4	1	3	1	6	6	0	0.547	0.478	1.000
93	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ALPI(1), ALPL(1), ALPP(1), ALPPL2(1), CYP2A13(2), CYP2A6(3), CYP2A7(1), CYP2C8(1), CYP2D6(1), CYP2F1(1), CYP3A7(1), CYP51A1(2)	7098325	16	14	16	1	2	4	1	6	3	0	0.0611	0.489	1.000
94	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(1), JAK1(2), STAT1(1), STAT2(1)	2627593	5	5	5	0	1	0	0	2	2	0	0.171	0.490	1.000
95	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ENPP1(4), ENPP3(1), FLAD1(1)	2345468	6	5	6	0	0	1	0	4	1	0	0.316	0.501	1.000
96	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(1), GPT(2), MDH1(1), ME2(1), RPE(1), RPIA(1), TKT(1), TPI1(1)	4371448	9	9	9	1	1	1	2	2	3	0	0.327	0.516	1.000
97	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), GBA(1), MPO(2), PRDX6(2)	2039185	6	6	6	2	1	0	2	2	1	0	0.684	0.521	1.000
98	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNE1(1), CCNE2(1), CDKN2A(1), E2F2(1)	2183798	4	4	4	1	0	1	1	1	1	0	0.592	0.525	1.000
99	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOC(1), TPI1(1)	940999	2	2	2	1	0	0	1	0	1	0	0.916	0.528	1.000
100	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(1), CYP17A1(2)	1672778	5	3	5	0	1	0	0	4	0	0	0.311	0.529	1.000
101	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(3), ACADL(3), ACADSB(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), HADHA(2), LDHB(1), PCCA(1), SUCLA2(1), SUCLG1(1)	8001737	20	20	20	3	1	4	5	7	2	1	0.0985	0.531	1.000
102	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(1), GPT(2), MDH1(1), PGK2(1), RPE(1), RPIA(1), TKT(1), TKTL2(1), TPI1(1)	4882125	10	10	10	1	1	1	2	3	3	0	0.281	0.534	1.000
103	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), GREB1(4), MTA1(1), MTA3(1), PDZK1(1)	2685703	9	7	9	2	1	1	1	3	3	0	0.677	0.543	1.000
104	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(3), ADH4(1), ADH6(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), BAAT(1), CEL(2), SOAT2(1), SRD5A1(1)	5617925	16	15	16	3	2	1	3	7	3	0	0.414	0.546	1.000
105	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(3), PLA2G2D(1), PLA2G4A(1), PLA2G6(1)	2492309	7	7	7	2	0	3	0	3	1	0	0.533	0.551	1.000
106	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH4(1), ADH6(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2)	3218462	8	8	8	2	1	1	3	3	0	0	0.482	0.557	1.000
107	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	LARS(4)	2415433	4	4	4	0	1	0	1	0	2	0	0.476	0.559	1.000
108	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(2), HDC(1)	1468369	3	3	3	1	0	1	0	1	1	0	0.742	0.560	1.000
109	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1A(1), BMPR1B(1)	1510342	3	3	3	0	0	1	0	1	1	0	0.334	0.561	1.000
110	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	PAPSS2(2), SULT1E1(2)	2226255	4	4	4	1	0	2	1	1	0	0	0.464	0.563	1.000
111	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B1(1), CYP17A1(2), CYP21A2(1)	2281329	5	4	5	1	1	0	0	2	2	0	0.631	0.574	1.000
112	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B1(1), CYP17A1(2), CYP21A2(1)	2281329	5	4	5	1	1	0	0	2	2	0	0.631	0.574	1.000
113	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(2)	1134812	2	2	2	0	0	1	0	1	0	0	0.582	0.575	1.000
114	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), GART(2), MTHFD1(3), MTHFD1L(1), MTHFD2(1), SHMT2(2), TYMS(1)	4600541	11	11	11	2	0	2	3	5	1	0	0.427	0.581	1.000
115	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB11(1), ABCB4(3), ABCC1(2), GSTP1(2)	3468826	8	8	8	2	1	3	2	1	1	0	0.372	0.583	1.000
116	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(1), F2R(1), PLG(2), SERPINB2(1)	3233348	8	8	8	2	2	1	1	3	1	0	0.607	0.584	1.000
117	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	TGFBR1(1), TGFBR2(1), TOB1(3)	2568545	5	5	5	0	0	1	1	3	0	0	0.260	0.589	1.000
118	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	782278	1	1	1	0	0	1	0	0	0	0	0.628	0.597	1.000
119	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A1(1), EIF4A2(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(1), EIF4G3(4), IRS1(1), PABPC1(1), PIK3CA(2), PIK3R1(2), PTEN(5)	6795039	21	18	21	3	1	4	3	5	8	0	0.236	0.599	1.000
120	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNGR1(1), JAK1(2), JAK2(1), STAT1(1)	2758507	7	7	7	2	1	0	0	5	1	0	0.762	0.602	1.000
121	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), JAK1(2), JAK2(1), JAK3(1), PIAS3(1), SRC(1)	3707857	8	7	8	1	1	1	1	4	1	0	0.400	0.606	1.000
122	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP29(1), STX11(1), STX17(1), STX18(1), STX2(1), STX4(1), STX5(1), TSNARE1(1), USE1(1)	4069819	9	9	9	2	2	1	1	4	1	0	0.434	0.613	1.000
123	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(1), GLS(2)	1874708	3	3	3	0	0	0	1	1	1	0	0.569	0.616	1.000
124	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	AKT1(1), ATM(1), CPB2(1), HIC1(1), HIF1A(1), TP53(4)	5044450	9	9	9	1	0	0	0	6	2	1	0.389	0.622	1.000
125	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), DOT1L(6), EHHADH(1), EHMT1(1), EHMT2(3), HADHA(2), PLOD2(1), SHMT2(2)	8934729	26	22	26	3	3	4	4	12	3	0	0.0356	0.625	1.000
126	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), SCAP(2), SREBF1(2), SREBF2(2)	2978981	7	7	7	2	0	0	2	4	1	0	0.727	0.630	1.000
127	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), JAK1(2), JAK3(1), RAF1(2), SOS1(3), STAT5A(1)	5705006	11	11	11	1	2	1	1	2	5	0	0.208	0.632	1.000
128	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), PAH(2), YARS2(1)	2104714	4	4	4	0	0	0	1	2	1	0	0.497	0.635	1.000
129	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(3), SELL(1), TNF(1), TNFRSF1B(1), TNFSF8(1)	3273177	7	6	7	1	0	2	1	2	2	0	0.383	0.642	1.000
130	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), JAK1(2), STAT1(1), STAT2(1)	3027593	5	5	5	0	1	0	0	2	2	0	0.162	0.643	1.000
131	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ARG2(1), CKB(1), CPS1(1), NAGS(1), OAT(1)	4287252	8	8	8	1	0	0	1	4	3	0	0.610	0.655	1.000
132	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	CHPF(1), CHST3(1), CHST7(1), UST(1), XYLT1(2)	3434015	6	6	6	1	1	1	0	2	2	0	0.475	0.655	1.000
133	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1)	723581	1	1	1	1	0	0	0	1	0	0	0.979	0.659	1.000
134	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	SOS1(3), SRC(1)	2126898	4	4	4	1	0	1	0	1	2	0	0.577	0.664	1.000
135	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(1), ACO1(1), ACSS1(1), FH(2), IDH2(1), MDH1(1), SUCLA2(1)	3215949	8	7	8	3	0	0	0	3	5	0	0.836	0.669	1.000
136	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(2)	1214742	2	2	2	0	0	0	0	1	1	0	0.836	0.669	1.000
137	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UGDH(1)	946985	1	1	1	0	0	0	1	0	0	0	0.699	0.677	1.000
138	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CTLA4(2), DAG1(3), FBXW7(2), ITPKA(1), ITPKB(1), LCP2(2), NFAT5(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(2), RAF1(2), RASGRP1(1), RASGRP3(1), SOS1(3), SOS2(1), VAV1(1), ZAP70(1)	13646744	37	31	37	4	3	7	5	11	11	0	0.0191	0.679	1.000
139	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNE1(1), CUL1(2)	2074980	3	3	3	0	1	0	2	0	0	0	0.323	0.687	1.000
140	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CUL1(2)	2070731	3	3	3	0	1	0	2	0	0	0	0.329	0.688	1.000
141	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CTH(1), LDHB(1), SULT1C2(1), SULT1C4(2)	3036352	5	5	5	1	0	0	3	2	0	0	0.531	0.695	1.000
142	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(2), INS(1), IRS1(1), PIK3CA(2), PIK3R1(2), PTPN11(1), RAF1(2), RASA1(2), SLC2A4(1), SOS1(3)	6160478	17	16	17	3	2	3	0	6	6	0	0.356	0.696	1.000
143	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B4GALT1(1), CHST2(1), CHST6(1), ST3GAL4(1)	2994315	5	5	5	1	2	1	0	2	0	0	0.390	0.697	1.000
144	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(3), LEPR(1), PRKAG2(2)	3484515	6	6	6	1	0	1	2	2	1	0	0.420	0.700	1.000
145	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(1), IFNAR1(1), NFKB1(1), RELA(1)	2677606	4	4	4	1	1	0	0	1	2	0	0.667	0.703	1.000
146	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	GAD1(2), GAD2(1), HDC(1), MAOA(1), PAH(2), SLC18A3(1)	3521301	8	8	8	2	0	2	1	4	1	0	0.511	0.703	1.000
147	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	LSS(2), NQO2(1), SQLE(1)	2712608	4	4	4	0	0	2	1	0	1	0	0.227	0.704	1.000
148	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPL(1), ALPP(1), ALPPL2(1)	1608829	4	4	4	2	1	2	1	0	0	0	0.667	0.705	1.000
149	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(3), GALNT10(2), GALNT11(1), GALNT14(1), GALNT2(1), GALNT4(1), GALNT5(1), GALNT6(2), GALNT7(1), GALNTL5(1), GCNT3(2), GCNT4(1), OGT(1), WBSCR17(1)	7814738	19	17	18	3	1	2	6	3	7	0	0.186	0.706	1.000
150	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(1), ACO1(1), CLYBL(1), DLD(2), FH(2), IDH2(1), IDH3B(1), MDH1(1), OGDH(5), PC(5), PCK1(1), PCK2(1), SDHA(2), SDHD(1), SUCLA2(1), SUCLG1(1)	7219475	27	23	27	8	1	3	3	8	10	2	0.630	0.706	1.000
151	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(1), MPO(2), PRDX6(2), SHMT2(2)	2818501	7	7	7	2	1	0	2	3	1	0	0.628	0.710	1.000
152	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	LDLR(1), LPL(1)	1283635	2	2	2	1	0	0	0	2	0	0	0.866	0.712	1.000
153	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA7(1), PSMB1(2), PSMB10(1)	2118461	5	5	5	2	1	0	0	3	1	0	0.780	0.721	1.000
154	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), BAD(1), CHRNB1(2), MUSK(1), PIK3CA(2), PIK3R1(2), PTK2(1), RAPSN(1), SRC(1), TERT(3)	3998241	15	15	15	4	0	2	2	9	2	0	0.582	0.721	1.000
155	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), EHHADH(1), HADHA(2), HSD17B4(1), NTAN1(1)	2873255	7	7	7	2	0	1	1	4	1	0	0.567	0.724	1.000
156	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(1), JAK1(2), JAK2(1), STAT1(1)	1968166	5	5	5	2	1	0	0	4	0	0	0.870	0.724	1.000
157	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(1), MPO(2), PRDX6(2), SHMT2(2)	2875724	7	7	7	2	1	0	2	3	1	0	0.621	0.726	1.000
158	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	DNMT1(2), PTGDR(1), PTGFR(2), PTGIR(1)	2721188	6	5	6	2	1	0	2	2	1	0	0.727	0.729	1.000
159	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15B(1), ALOX5(2), GGT1(1), PLA2G6(1), PTGS2(1), TBXAS1(1)	3719306	8	8	8	2	0	1	2	3	2	0	0.520	0.735	1.000
160	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(2), JAK2(1), JAK3(1), PIAS1(1), PIAS3(1)	3345250	8	7	8	2	1	1	2	3	1	0	0.586	0.736	1.000
161	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	BST1(2), ENPP1(4), ENPP3(1), NADK(1), NNT(1), NT5C1B(1)	5209025	10	9	9	1	0	0	0	9	1	0	0.433	0.738	1.000
162	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(2), IGF1R(1), IRS1(1), PIK3CA(2), PIK3R1(2), PTPN11(1), RAF1(2), RASA1(2), SOS1(3)	5979883	16	15	16	3	2	3	0	5	6	0	0.399	0.738	1.000
163	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	NFKB1(1), NOX1(1), RELA(1), TNF(1)	2418041	4	4	4	1	0	0	1	1	2	0	0.850	0.740	1.000
164	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(1), BRAF(2), CAMP(1), RAF1(2), SNX13(1), SRC(1)	2744561	9	8	9	3	1	0	1	4	3	0	0.804	0.744	1.000
165	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(1), TNF(1), TNFRSF1B(1)	2049649	3	3	3	1	0	1	0	1	1	0	0.869	0.747	1.000
166	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), LDHB(1)	1641762	2	2	2	1	0	0	1	1	0	0	0.841	0.750	1.000
167	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	EHHADH(1), HADHA(2)	1891303	3	3	3	1	0	0	0	3	0	0	0.795	0.751	1.000
168	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(1), ERBB3(1), NRG1(2)	2484594	4	4	4	0	0	1	0	2	1	0	0.315	0.754	1.000
169	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	PTPRC(2), ZAP70(1)	2179528	3	3	3	1	0	0	0	1	2	0	0.803	0.756	1.000
170	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(1), FUT6(1)	1233787	2	2	2	0	0	0	0	2	0	0	0.669	0.757	1.000
171	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1)	750598	1	1	1	0	0	0	0	1	0	0	0.833	0.759	1.000
172	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(1), ST3GAL4(1)	1899893	3	3	3	0	1	0	0	2	0	0	0.489	0.766	1.000
173	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLUD2(6)	1094435	8	8	6	4	0	0	3	4	1	0	0.883	0.768	1.000
174	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(1), DPAGT1(2), MGAT2(1), MGAT3(1), MGAT5(1), RPN1(1), ST6GAL1(1)	4841177	9	7	9	0	1	3	0	1	4	0	0.0401	0.768	1.000
175	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(1), CCNE1(1), TP53(4)	4374716	7	7	7	0	0	0	1	3	3	0	0.152	0.768	1.000
176	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	AGT(3), AGTR2(1), COL4A1(1), COL4A2(1), COL4A3(2), COL4A4(1), COL4A5(1), COL4A6(3)	6170600	13	12	13	2	0	2	1	9	1	0	0.250	0.768	1.000
177	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CBL(1), CSF1R(1), EGF(1), PDGFRA(1), SH3KBP1(2), SRC(1)	4007280	7	6	7	1	1	1	0	4	1	0	0.525	0.775	1.000
178	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1)	1628655	2	2	2	0	1	0	0	1	0	0	0.585	0.775	1.000
179	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UGDH(1)	1198581	1	1	1	0	0	0	1	0	0	0	0.687	0.781	1.000
180	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR2(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(2)	3663909	7	7	7	2	1	1	0	3	2	0	0.661	0.782	1.000
181	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	PTGS2(1)	1278741	1	1	1	0	0	0	1	0	0	0	0.751	0.789	1.000
182	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT2(1)	1490278	2	2	2	0	0	0	0	2	0	0	0.693	0.791	1.000
183	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(1), JAK3(1)	2875770	4	4	4	1	1	0	1	2	0	0	0.682	0.792	1.000
184	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1)	779369	1	1	1	1	0	0	0	1	0	0	0.932	0.792	1.000
185	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(1), PGM1(1)	2498953	4	4	4	1	1	0	0	3	0	0	0.645	0.794	1.000
186	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), EPOR(2), JAK2(1), PLCG1(1), RAF1(2), SOS1(3), STAT5A(1)	5239741	12	11	12	2	1	1	1	4	5	0	0.413	0.794	1.000
187	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	KERA(1)	867185	1	1	1	0	0	0	0	1	0	0	0.840	0.795	1.000
188	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL4(1), ST6GALNAC2(1)	1365205	2	2	2	0	1	0	0	1	0	0	0.547	0.796	1.000
189	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), MDH1(1), PC(5), SLC25A1(1)	2245654	8	7	8	4	0	0	1	4	3	0	0.945	0.800	1.000
190	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(1), CDH1(1), CREBBP(4), EP300(5), MAP3K7(1), SKIL(1), TGFBR1(1), TGFBR2(1)	6195815	15	14	15	3	0	3	1	5	5	1	0.448	0.800	1.000
191	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4R(1), IRS1(1), JAK1(2), JAK3(1), STAT6(1)	3591542	7	7	7	2	2	0	1	3	1	0	0.596	0.800	1.000
192	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(1), PTPRB(2), RAF1(2), RASA1(2), SOS1(3), SPRY2(1), SRC(1)	6040768	13	13	13	2	0	2	1	6	4	0	0.337	0.801	1.000
193	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH4A1(1), AMD1(2), AOC2(1), AOC3(1), ARG2(1), CKB(1), CPS1(1), MAOA(1), MAOB(2), NOS1(1), NOS3(1), OAT(1), P4HA1(1), P4HB(1), RARS(1)	10762799	24	23	24	3	4	2	6	8	4	0	0.0775	0.804	1.000
194	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), ANXA4(2), ANXA6(1), CYP11A1(1), PLA2G4A(1), PTGDR(1), PTGFR(2), PTGIR(1), PTGS2(1), TBXAS1(1)	4981768	12	10	12	3	2	0	3	4	3	0	0.501	0.805	1.000
195	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), MPO(2), PRDX6(2)	2351166	5	5	5	2	1	0	2	1	1	0	0.741	0.806	1.000
196	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(4), EP300(5), NCOA3(3), PRKAR2A(1), PRKAR2B(1)	5007443	14	14	14	9	0	2	1	3	8	0	0.978	0.811	1.000
197	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	PSAT1(1)	1167383	1	1	1	1	0	0	0	0	1	0	1.000	0.813	1.000
198	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(2), GATA1(2), UROD(1)	1942686	5	5	5	4	2	1	0	0	2	0	0.947	0.813	1.000
199	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(1), F2R(1), F5(3), PROS1(1), TFPI(1)	3962866	8	8	8	2	1	0	1	3	3	0	0.768	0.815	1.000
200	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), THBS1(4)	1767161	5	5	5	4	0	0	3	0	2	0	0.982	0.815	1.000
201	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), LSS(2), SQLE(1)	3222762	5	4	5	0	0	2	0	1	2	0	0.275	0.816	1.000
202	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(2), GNAS(1), GNB1(1), LIMK1(2), NOX1(1), PIK3C2G(2), PLCB1(1), PTK2(1), RAF1(2), ROCK2(1)	6139095	14	14	14	3	2	4	3	2	3	0	0.357	0.818	1.000
203	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(3), AGTR2(1), EGF(1), NFKB1(1), PLCG1(1), RELA(1)	4957872	10	8	10	1	1	1	0	7	1	0	0.325	0.824	1.000
204	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(3), ACADL(3), ACADSB(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), BCKDHA(1), EHHADH(1), HADHA(2), HMGCL(2), MCCC1(1), PCCA(1)	8729350	21	20	21	4	1	3	4	9	3	1	0.219	0.824	1.000
205	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1)	911442	1	1	1	0	0	0	0	0	1	0	1.000	0.827	1.000
206	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(1), ITGB1(2), PIK3CA(2), PIK3R1(2), PTEN(5), PTK2(1), SOS1(3)	4688560	17	16	17	5	0	3	3	4	7	0	0.629	0.833	1.000
207	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HMGCL(2)	6251760	14	14	14	3	1	2	3	6	2	0	0.336	0.836	1.000
208	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(1), ALOX12B(1), ALOX15B(1), ALOX5(2), CBR1(1), CYP2C8(1), CYP4A11(1), CYP4A22(1), CYP4F2(1), CYP4F3(2), GGT1(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PTGS2(1), TBXAS1(1)	9527579	20	19	20	3	2	2	2	10	4	0	0.216	0.839	1.000
209	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), LCT(3), ST6GALNAC5(2)	3974321	6	5	6	1	1	1	0	3	1	0	0.567	0.840	1.000
210	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2I(1), UBE2L3(1), UBE2N(2), UBE3A(1)	2542079	5	5	5	2	0	0	1	4	0	0	0.808	0.843	1.000
211	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(2), GFPT1(1), HK1(1), RENBP(2)	4117909	7	7	7	1	0	0	0	6	1	0	0.585	0.843	1.000
212	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(1), COL4A3(2), COL4A4(1), COL4A5(1), COL4A6(3), P4HB(1), SLC23A1(2), SLC23A2(1), SLC2A1(1)	6165637	14	13	14	3	0	2	2	8	2	0	0.379	0.847	1.000
213	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	ENPP1(4), ENPP3(1), NNT(1)	3527759	6	5	6	1	0	0	0	5	1	0	0.669	0.850	1.000
214	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	PAH(2)	1999130	2	2	2	0	0	0	1	1	0	0	0.610	0.852	1.000
215	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(1), ITGB1(2), KLRC1(1), KLRC3(1), PAK1(1), PIK3CA(2), PIK3R1(2), VAV1(1)	4526385	12	10	12	3	0	2	1	4	3	2	0.808	0.853	1.000
216	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B4GALT1(1), FUT2(1), FUT4(1), FUT6(1), FUT7(1)	3897416	6	6	6	1	1	0	0	4	1	0	0.558	0.853	1.000
217	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	IL9(1)	1487765	1	1	1	0	0	0	1	0	0	0	0.739	0.856	1.000
218	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CTH(1)	1190025	1	1	1	1	0	0	0	1	0	0	0.945	0.856	1.000
219	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(1), ITPKA(1), PLCB1(1), PLCB2(2)	2687145	5	5	5	2	1	0	0	1	3	0	0.903	0.857	1.000
220	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1)	1605146	1	1	1	0	0	1	0	0	0	0	0.710	0.860	1.000
221	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	NFKB1(1), NFKBIA(2), RELA(1), TP53(4)	2422602	8	8	8	3	1	0	0	5	2	0	0.802	0.861	1.000
222	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCL(2)	1755551	2	2	2	0	0	0	0	1	1	0	0.554	0.861	1.000
223	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), AKT2(2), AKT3(2), BAD(1), GSK3A(1), IL4R(1), IRS1(1), IRS2(2), JAK1(2), JAK3(1), MAP4K1(2), PIK3CA(2), PIK3CD(1), PIK3R1(2), RAF1(2), SOS1(3), SOS2(1), STAT6(1)	8878453	28	24	28	5	3	5	5	8	7	0	0.132	0.862	1.000
224	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	NDUFB11(1)	990437	1	1	1	1	0	0	0	0	1	0	0.972	0.863	1.000
225	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	16	AHCY(4), AMD1(2), CTH(1), DNMT1(2), DNMT3A(4), DNMT3B(2), MARS(1), MARS2(1), MAT1A(1), MAT2B(1)	4841464	19	18	19	5	2	3	2	6	6	0	0.594	0.865	1.000
226	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGEF2(2), CLTA(1), CLTB(1), GBF1(6), GPLD1(1), KDELR3(2)	3921570	14	14	14	7	0	1	2	6	5	0	0.953	0.866	1.000
227	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), NFKBIA(2), PLCB1(1), RELA(1)	1995037	5	5	5	3	1	0	0	2	2	0	0.956	0.868	1.000
228	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	DLG4(1), F2(1), F2RL2(1), MAP2K5(2), MAPK7(3), MYEF2(1), PTK2(1), RAF1(2), RASAL1(1), SRC(1), VAV1(1)	6693005	15	15	14	3	2	2	2	8	1	0	0.306	0.869	1.000
229	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	EP300(5), HIF1A(1), NOS3(1), P4HB(1), VHL(2)	4123274	10	10	10	3	1	0	0	4	4	1	0.895	0.871	1.000
230	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(1), PGM1(1)	2851686	4	4	4	1	1	0	0	3	0	0	0.634	0.874	1.000
231	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1)	3644944	5	5	5	1	0	1	0	4	0	0	0.592	0.874	1.000
232	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1)	3644944	5	5	5	1	0	1	0	4	0	0	0.592	0.874	1.000
233	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1)	3644944	5	5	5	1	0	1	0	4	0	0	0.592	0.874	1.000
234	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), NR3C1(2), TNF(1)	1395601	4	4	4	3	0	0	1	2	1	0	0.964	0.878	1.000
235	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), F2R(1), GNB1(1), ITGA1(3), ITGB1(2), PLA2G4A(1), PLCB1(1), PTK2(1), RAF1(2), SRC(1), TBXAS1(1)	5880272	15	15	15	4	1	0	2	7	5	0	0.727	0.879	1.000
236	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLRMT(2)	3275763	12	12	12	4	2	1	1	5	3	0	0.729	0.880	1.000
237	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK2A(1), CAMKK1(2)	2845316	5	5	5	2	1	0	2	1	1	0	0.693	0.882	1.000
238	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD58(1)	1504884	1	1	1	0	0	0	1	0	0	0	0.709	0.882	1.000
239	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), METTL2B(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1)	3415511	7	6	7	3	0	0	1	2	4	0	0.785	0.887	1.000
240	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), FDXR(2)	3878501	7	7	7	2	0	1	0	6	0	0	0.654	0.887	1.000
241	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(1), CREBBP(4), HMGB2(2)	2573972	8	8	8	3	1	2	2	0	3	0	0.538	0.888	1.000
242	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	NFATC2(3), NFATC3(2), PLCG1(1), PPP3CA(1)	5036380	7	7	7	1	1	0	0	3	3	0	0.650	0.889	1.000
243	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	DCXR(1), RPE(1), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1)	4236743	7	7	7	2	0	1	4	1	1	0	0.549	0.891	1.000
244	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	FUT2(1), ST3GAL4(1)	1739627	2	2	2	0	0	0	0	2	0	0	0.692	0.895	1.000
245	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(1), H6PD(2), PFKP(1), PGM1(1), PRPS2(1), RBKS(1), RPE(1), RPIA(1), TAL1(1), TKT(1)	4926039	11	11	11	3	3	1	1	3	3	0	0.640	0.898	1.000
246	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BAK1(1), BID(1), BIRC3(1), CASP9(1), DIABLO(1)	3281438	6	6	6	2	1	2	1	1	1	0	0.653	0.898	1.000
247	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(3), LCT(3), PGM1(1), PYGL(1), PYGM(1), TPI1(1)	3269977	11	11	11	4	3	0	2	5	1	0	0.713	0.900	1.000
248	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(3), AGT(3), AGTR2(1), ANPEP(2), ENPEP(2), LNPEP(1)	5110768	12	10	12	3	1	2	2	6	1	0	0.502	0.900	1.000
249	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1)	1313330	1	1	1	1	0	0	0	1	0	0	0.930	0.901	1.000
250	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(2), GALNT2(1), GALNT4(1), GALNT6(2), GALNT7(1), ST3GAL4(1), WBSCR17(1)	3511712	9	9	9	3	0	1	1	3	4	0	0.731	0.901	1.000
251	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(3), ALDH1B1(2), ALDH2(2), ALDH3A2(2), BCKDHA(1), DBT(2), DLD(2), EHHADH(1), HADHA(2), HIBCH(1), HMGCL(2), HSD17B4(1), MCCC1(1), PCCA(1)	10472795	23	21	23	4	1	2	7	9	3	1	0.147	0.904	1.000
252	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(1), C6(2), C7(1), ICAM1(1), ITGA4(1), ITGAL(2), ITGB1(2), ITGB2(1), TNF(1), VCAM1(2)	5973810	14	12	14	3	1	1	1	9	2	0	0.622	0.906	1.000
253	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(3), ACACB(1), ACSS1(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), HADHA(2), HIBCH(1), LDHB(1), PCCA(1), SUCLA2(1), SUCLG1(1)	9600110	19	19	19	3	1	3	6	6	3	0	0.122	0.906	1.000
254	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(2), UROD(1)	1852416	3	3	3	3	1	1	0	0	1	0	0.943	0.909	1.000
255	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), EPX(1), HPD(2), MAOA(1), MAOB(2), MPO(2), PRDX6(2)	5352490	14	13	14	4	4	1	2	5	2	0	0.493	0.914	1.000
256	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), BAIAP2(1), CASP1(1), GAPDH(2), INS(1), MAGI1(1), MAGI2(2), RERE(7), WWP1(6), WWP2(1)	5791683	23	22	23	6	4	0	2	11	6	0	0.755	0.915	1.000
257	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	METTL2B(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1)	3638552	6	5	6	3	0	0	1	1	4	0	0.847	0.916	1.000
258	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	TNF(1)	1579608	1	1	1	0	0	0	0	0	1	0	1.000	0.918	1.000
259	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACMSD(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), AOC2(1), AOC3(1), CYP2A13(2), CYP2A6(3), CYP2A7(1), CYP2C8(1), CYP2D6(1), CYP2F1(1), CYP3A7(1), CYP51A1(2), EHHADH(1), HAAO(1), HADHA(2), KYNU(1), MAOA(1), MAOB(2)	13314477	30	24	30	3	4	4	3	14	5	0	0.0357	0.920	1.000
260	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(1), CHEK1(1), MYT1(2), TP53(4)	4252861	8	8	8	2	0	0	1	5	2	0	0.566	0.921	1.000
261	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), IFNGR1(1), IL12RB1(1), IL4R(1)	3065997	5	5	5	2	0	0	0	2	3	0	0.912	0.921	1.000
262	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), HADHA(2), PNPLA3(1), YOD1(1)	7465336	12	12	12	2	1	2	3	4	2	0	0.315	0.924	1.000
263	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	TIMP2(1)	1833353	1	1	1	1	0	0	0	0	1	0	1.000	0.924	1.000
264	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(2), AKT3(2), MAP2K2(1), NTRK1(2), PIK3CA(2), PIK3CD(1), SOS1(3)	3955810	14	11	14	4	1	3	1	5	4	0	0.388	0.926	1.000
265	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), ITGAX(4), TLR4(1), TLR7(1)	4494682	8	7	8	2	2	0	2	3	1	0	0.411	0.928	1.000
266	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC2(1), AOC3(1), CES1(1), LIPA(1), PNPLA3(1), PRDX6(2)	6113002	7	7	7	0	0	2	2	1	2	0	0.162	0.929	1.000
267	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(2), PIK3R1(2), PLCB1(1), PLCG1(1), VAV1(1)	3099761	8	8	8	3	0	2	0	4	2	0	0.869	0.930	1.000
268	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(5), SRC(1)	3621849	10	10	10	6	0	2	1	3	4	0	0.951	0.932	1.000
269	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(1), CRKL(1), DOCK1(2), GAB1(1), ITGA1(3), ITGB1(2), MAP2K2(1), MAP4K1(2), PAK1(1), PIK3CA(2), PIK3R1(2), PTEN(5), PTK2(1), PTPN11(1), PXN(1), RAF1(2), RASA1(2), SOS1(3), SRC(1)	10114871	34	30	34	7	0	4	5	12	13	0	0.458	0.935	1.000
270	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(2), LCT(3), MANBA(1)	4046423	6	6	6	2	1	0	1	3	1	0	0.785	0.936	1.000
271	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(2), ABCC2(3), ABCG2(2), BCHE(1), CES1(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1)	5493033	13	13	13	4	0	2	4	4	3	0	0.621	0.937	1.000
272	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA1(1), CA6(1), CA9(1), CPS1(1), CTH(1), GLS(2), GLUL(2)	4583996	10	10	10	3	0	1	2	4	3	0	0.768	0.938	1.000
273	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), NTRK1(2), PIK3CA(2), PIK3R1(2), PLCG1(1), SOS1(3)	3764807	11	10	11	5	0	3	0	4	4	0	0.805	0.938	1.000
274	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(4), CTH(1), GGT1(1), MARS(1), MARS2(1), MAT1A(1), MAT2B(1), PAPSS2(2), SCLY(1)	3006316	13	12	13	5	0	5	2	3	3	0	0.693	0.939	1.000
275	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), RPL10A(1), RPL11(1), RPL13(1), RPL14(1), RPL18(1), RPL19(1), RPL24(1), RPL26(1), RPL3(2), RPL3L(1), RPL6(1), RPS2(1), RPS24(1), RPS7(1), RPS8(1), RPSA(1)	5437011	18	18	18	7	2	2	2	5	7	0	0.889	0.940	1.000
276	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	CFTR(3), GNAS(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(1)	3190415	7	7	7	5	1	0	1	2	3	0	0.949	0.941	1.000
277	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(3), ACAD8(2), ACAD9(1), ADH4(1), ADH6(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), BAAT(1), CEL(2), LIPA(1), RDH11(1), RDH13(1), SOAT2(1), SRD5A1(1)	7702614	22	21	22	5	2	2	3	11	4	0	0.490	0.944	1.000
278	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	IL9(1)	2025594	1	1	1	1	0	0	1	0	0	0	0.956	0.945	1.000
279	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(5), LPL(1), NCOA1(1), NCOA2(2)	4448644	13	13	13	9	1	3	1	3	5	0	0.989	0.945	1.000
280	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(2), CASP1(1), CASP10(1), CASP9(1)	3092050	6	6	6	3	0	1	1	1	3	0	0.950	0.947	1.000
281	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(1), TFRC(1)	3097339	3	3	3	0	0	0	0	3	0	0	0.615	0.953	1.000
282	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), JAK2(1), RAF1(2), SOS1(3), STAT5A(1)	4294331	8	7	8	2	0	1	0	3	4	0	0.685	0.953	1.000
283	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(1), C6(2), C7(1)	3038601	4	3	4	1	0	0	0	4	0	0	0.826	0.953	1.000
284	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CHEK1(1)	1727314	1	1	1	0	0	0	0	1	0	0	0.847	0.953	1.000
285	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), DARS(2), EPRS(2), LARS(4), MARS(1), MARS2(1), RARS(1)	7715743	12	11	12	2	1	1	1	4	5	0	0.551	0.954	1.000
286	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(2), PIK3CA(2), PIK3R1(2), PLCG1(1), RAF1(2), SOS1(3)	4616487	12	12	12	4	1	3	0	3	5	0	0.742	0.956	1.000
287	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ATF3(1), EIF4EBP1(1), IL1R1(1), WDR1(1)	2625205	4	4	4	2	0	1	1	2	0	0	0.851	0.958	1.000
288	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(2), LCT(3), MAN2B1(1), MANBA(1)	4987788	7	7	7	2	2	0	1	3	1	0	0.679	0.958	1.000
289	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC3(1), CASP10(1), CASP9(1), SCAP(2), SREBF1(2), SREBF2(2)	4498040	10	10	10	3	0	1	2	4	3	0	0.722	0.958	1.000
290	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), JAK1(2), JAK2(1)	2532952	4	4	4	2	1	0	0	2	1	0	0.803	0.958	1.000
291	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), JAK1(2), JAK2(1)	2532952	4	4	4	2	1	0	0	2	1	0	0.803	0.958	1.000
292	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), HDAC9(1)	1943278	3	3	3	2	1	0	1	0	1	0	0.763	0.961	1.000
293	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(4), CTH(1), GGT1(1), MARS(1), MARS2(1), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS2(2), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1), SCLY(1), SEPHS2(2)	6054270	21	18	21	7	0	5	4	5	7	0	0.593	0.961	1.000
294	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), PTPRA(1), SRC(1)	2240029	3	3	3	2	0	1	0	2	0	0	0.903	0.962	1.000
295	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), BAD(1), IGF1R(1), IRS1(1), PIK3CA(2), PIK3R1(2), RAF1(2), SOS1(3)	4558520	13	12	13	4	1	3	1	4	4	0	0.621	0.964	1.000
296	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA7(1), PSMB1(2), PSMD1(1), PSMD11(1), PSMD6(1)	3869959	7	7	7	5	2	0	0	2	3	0	0.974	0.965	1.000
297	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(1), C3(1), C6(2), C7(1), MASP1(1), MBL2(1)	5189042	7	6	7	1	0	0	1	6	0	0	0.572	0.965	1.000
298	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(2), AKT3(2), BAD(1), BCR(1), DAG1(3), ITPKA(1), ITPKB(1), LYN(1), MAP2K2(1), NFAT5(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), PI3(1), PIK3CA(2), PIK3CD(1), PIK3R1(2), PLCG2(2), RAF1(2), SOS1(3), SOS2(1), VAV1(1)	12813132	36	30	36	6	3	5	4	14	10	0	0.142	0.965	1.000
299	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	EPOR(2), HIF1A(1), JAK2(1), NFKB1(1), NFKBIA(2), RELA(1)	3101695	8	7	8	4	1	0	1	4	1	1	0.923	0.965	1.000
300	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(2), CETP(1), DGAT1(2), LCAT(2), LDLR(1), LPL(1), LRP1(1), SCARB1(1)	6623174	11	9	11	2	1	1	1	7	1	0	0.401	0.965	1.000
301	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLR3A(1), POLR3B(2)	5663978	14	14	14	4	3	1	0	7	3	0	0.668	0.967	1.000
302	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), GPT(2), LDHB(1)	2170579	5	5	5	3	0	0	3	1	1	0	0.917	0.968	1.000
303	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(3), ACADL(3), ACADSB(1), ACOX1(1), ACOX3(3), ACSL1(2), ACSL6(1), ADH4(1), ADH6(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), CYP4A11(1), CYP4A22(1), EHHADH(1), HADHA(2), HSD17B4(1)	11855739	28	26	28	6	2	7	3	13	2	1	0.232	0.970	1.000
304	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	NFKB1(1), RELA(1), TRAF5(2)	3537640	4	4	4	4	0	0	0	1	3	0	0.998	0.970	1.000
305	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(1), ST3GAL4(1)	2441241	2	2	2	0	0	0	0	2	0	0	0.693	0.970	1.000
306	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	GPR161(1), GPR18(2), GPR39(1), GPR65(1)	2369541	5	5	5	3	1	2	0	2	0	0	0.863	0.970	1.000
307	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), NFAT5(1), PDE6B(2), PDE6C(1), SLC6A13(4)	8731146	20	18	20	4	1	3	4	7	5	0	0.297	0.970	1.000
308	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	PON2(2), RDH11(1), RDH13(1)	2172765	4	4	4	3	0	0	0	3	1	0	0.969	0.971	1.000
309	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), CASP9(1), DAXX(1), FASLG(2), TNF(1)	2725855	7	5	7	3	0	3	1	0	3	0	0.877	0.972	1.000
310	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	MAP2K2(1), RAF1(2)	2008334	3	3	3	2	0	0	0	2	1	0	0.963	0.972	1.000
311	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4B(2), INPPL1(2), ITPKA(1), ITPKB(1), OCRL(1), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3CA(2), PIK3CB(1), PIK3CG(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), PLCD1(2), PLCG1(1), PLCG2(2)	10908611	28	26	28	5	2	6	2	11	7	0	0.248	0.973	1.000
312	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	SLC18A3(1)	1697779	1	1	1	1	0	0	0	1	0	0	0.927	0.974	1.000
313	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(2), AKT3(2), CISH(2), IL4R(1), JAK1(2), JAK2(1), JAK3(1), PI3(1), PIK3CA(2), SOS1(3), SOS2(1), SRC(1), STAT6(1)	8944386	21	17	21	4	2	4	2	8	5	0	0.195	0.974	1.000
314	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	NFKB1(1), NFKBIA(2), PLCB1(1), RAF1(2), RELA(1), TNF(1)	3744385	8	7	8	3	1	0	0	3	4	0	0.932	0.976	1.000
315	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(1), GNAS(1), GNB1(1), NFKB1(1), NOS3(1), NR3C1(2), PIK3CA(2), PIK3R1(2), RELA(1)	4389146	12	12	12	4	2	2	1	5	2	0	0.763	0.976	1.000
316	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), DOT1L(6), EHHADH(1), EHMT1(1), EHMT2(3), HADHA(2), HSD17B4(1), NSD1(5), OGDH(5), PIPOX(2), PLOD2(1), RDH11(1), RDH13(1), SETD1A(3), SETDB1(2), SHMT2(2), SUV39H2(1)	14054836	45	38	45	9	3	7	4	21	10	0	0.199	0.977	1.000
317	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(2), JAK2(1), PIK3CA(2), PIK3R1(2), PLCG1(1), RAF1(2), RASA1(2), SOS1(3), STAT1(1), STAT5A(1), THPO(1)	7235462	18	16	18	4	1	3	0	7	7	0	0.588	0.977	1.000
318	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL16(1), IL9(1), TNF(1)	2395022	3	3	3	2	0	1	1	0	1	0	0.933	0.978	1.000
319	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	KEAP1(1)	1895586	1	1	1	2	0	0	0	0	1	0	0.989	0.979	1.000
320	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(2), DIAPH1(2), GSN(2), ITGA1(3), ITGB1(2), PIK3CA(2), PIK3R1(2), PTK2(1), PXN(1), RAF1(2), SRC(1), TLN1(7)	9053608	27	23	27	7	0	3	3	10	11	0	0.785	0.979	1.000
321	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(4), DAXX(1), SP100(1), TNF(1), TNFRSF1B(1), TP53(4)	4611774	12	11	12	4	0	3	1	3	5	0	0.645	0.980	1.000
322	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), BAD(1), CBL(1), CRKL(1), IRS1(1), JAK1(2), JAK3(1), PIK3CA(2), PIK3R1(2), PPIA(1), RAF1(2), SOS1(3), STAT5A(1)	8781056	19	16	19	4	2	4	2	6	5	0	0.353	0.980	1.000
323	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	GABBR1(1), GPRC5D(1), GRM2(3), GRM4(3), GRM5(1)	5056128	9	8	9	3	3	3	0	2	1	0	0.425	0.980	1.000
324	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ARPC2(1), PAK1(1), PDGFRA(1), PIK3CA(2), PIK3R1(2)	3234331	8	8	8	6	1	3	0	2	2	0	0.987	0.982	1.000
325	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(1), CHEK1(1), MYT1(2)	3329632	4	4	4	2	0	0	1	2	1	0	0.814	0.982	1.000
326	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	JUNB(1), MAF(1), MAP2K3(1), NFATC2(3), PRKAR2A(1), PRKAR2B(1)	2951143	8	7	8	5	1	0	1	4	2	0	0.944	0.983	1.000
327	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH3B1(1), ALDH3B2(1), AMDHD1(1), AOC2(1), AOC3(1), HDC(1), HNMT(1), MAOA(1), MAOB(2), METTL2B(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1), PRPS2(1)	9651399	25	21	25	5	4	3	4	8	6	0	0.175	0.983	1.000
328	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(3), CDKN2A(1), PIK3CA(2), PIK3R1(2), POLR1A(1), POLR1B(2), TP53(4)	4908605	15	13	15	6	1	3	0	6	5	0	0.854	0.983	1.000
329	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	FHL5(1), GNAS(1), XPO1(2)	2324404	4	4	4	3	2	0	1	0	1	0	0.944	0.984	1.000
330	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), CAD(3), CPS1(1), EPRS(2), GAD1(2), GAD2(1), GCLC(3), GFPT1(1), GLS(2), GLUD2(6), GLUL(2), GMPS(1), GPT(2), NAGK(1), PPAT(1)	9570754	29	27	27	7	1	3	8	13	4	0	0.328	0.985	1.000
331	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(4), EP300(5), IKBKB(1), NFKB1(1), NFKBIA(2), RELA(1), TNF(1), TNFRSF1B(1)	5424636	16	15	16	6	1	3	1	5	6	0	0.860	0.985	1.000
332	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), CAPN1(1), ITGA1(3), ITGB1(2), ITGB3(2), PTK2(1), PXN(1), SPTAN1(4), SRC(1), TLN1(7)	6939909	23	21	23	7	0	3	3	10	7	0	0.722	0.985	1.000
333	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2S3(1), EIF4EBP1(1), IGF1R(1), INPPL1(2), PIK3CA(2), PIK3R1(2), PTEN(5)	4786378	15	14	15	5	2	3	2	4	4	0	0.718	0.985	1.000
334	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CMAS(1), GFPT1(1), HK1(1), MTMR2(2), MTMR6(1), NAGK(1), NANS(1), NPL(1), PHPT1(1), RENBP(2)	6965455	12	12	12	3	0	2	3	6	1	0	0.476	0.985	1.000
335	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSD(1), ARSE(1), CYP11B1(1), SRD5A1(1), SULT1E1(2), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1)	6593516	10	10	10	3	1	0	4	1	4	0	0.577	0.986	1.000
336	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(1), C3(1), C6(2), C7(1)	4259584	5	4	5	1	0	0	0	5	0	0	0.755	0.986	1.000
337	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK2A(1), ESRRA(1), HDAC5(3), PPP3CA(1), SLC2A4(1)	4999970	9	9	9	3	2	0	1	5	1	0	0.669	0.987	1.000
338	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), GNB1(1), PLCB1(1)	4988995	4	4	4	1	0	0	1	1	2	0	0.837	0.987	1.000
339	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(1), ATR(3), CHEK1(1), TP53(4)	3831555	9	9	9	3	0	1	0	6	2	0	0.752	0.988	1.000
340	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(1), AKT2(2), AKT3(2), BAD(1), CDKN2A(1), DAPP1(2), GSK3A(1), IGFBP1(1), PIK3CA(2), PTEN(5), RPS6KA1(1), RPS6KA3(2), SFN(1), SOS1(3), SOS2(1)	8705692	26	23	26	8	1	5	8	3	9	0	0.445	0.988	1.000
341	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(1), C3(1), C6(2), C7(1), MASP1(1)	5051102	6	5	6	1	0	0	0	6	0	0	0.692	0.989	1.000
342	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1), PRKAR2A(1), PRKAR2B(1)	2436182	3	3	3	4	0	0	0	2	1	0	0.992	0.989	1.000
343	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), BAD(1), CASP9(1), NFKB1(1), NFKBIA(2), PIK3CA(2), PIK3R1(2), RELA(1)	3412483	11	11	11	6	1	3	1	4	2	0	0.935	0.990	1.000
344	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(1), GNB1(1), PRKAR2A(1), PRKAR2B(1)	2359999	6	6	6	4	1	1	0	3	1	0	0.928	0.990	1.000
345	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH4(1), ADH6(1), AKR1C2(1), AKR1C3(2), ALDH3B1(1), ALDH3B2(1), CYP1B1(1), CYP2C8(1), CYP2F1(1), CYP3A43(2), CYP3A7(1), DHDH(3), EPHX1(1), GSTA1(1), GSTA2(1), GSTK1(1), GSTM1(1), GSTM4(1), GSTP1(2), GSTT1(2), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UGT2A3(1), UGT2B17(1), UGT2B28(1), UGT2B7(1)	13923237	34	31	34	7	4	2	5	17	6	0	0.350	0.990	1.000
346	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCR(1), CRKL(1), JAK2(1), MAP3K1(2), PIK3CA(2), PIK3R1(2), RAF1(2), SOS1(3), STAT1(1), STAT5A(1)	6758907	17	14	17	8	0	4	0	6	7	0	0.963	0.990	1.000
347	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNGR1(1), IKBKB(1), JAK2(1), NFKB1(1), NFKBIA(2), RELA(1), TNF(1), TNFRSF1B(1), TP53(4), USH1C(1)	4439852	14	13	14	6	1	1	0	9	3	0	0.929	0.991	1.000
348	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCNE1(1), NFKB1(1), NFKBIA(2), PAK1(1), PIK3CA(2), PIK3R1(2), RAF1(2), RELA(1)	4896134	13	12	13	4	1	2	1	5	4	0	0.805	0.991	1.000
349	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), EPX(1), HPD(2), MAOA(1), MAOB(2), MPO(2), PNPLA3(1), PRDX6(2)	8275947	15	14	15	4	4	2	2	5	2	0	0.431	0.992	1.000
350	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(3), CAPN2(2), EP300(5), NFATC2(3), PPP3CA(1)	5872708	14	14	14	5	2	0	0	7	5	0	0.940	0.992	1.000
351	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(4), EP300(5), IKBKB(1), MAP2K3(1), MAP3K7(1), NFKB1(1), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(1), TGFBR2(1), TNF(1)	7201443	21	18	21	6	1	3	2	8	6	1	0.670	0.992	1.000
352	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA7(1), PSMB1(2), RPN1(1), UBE3A(1)	3143161	6	6	6	4	1	1	0	3	1	0	0.909	0.993	1.000
353	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(1), LCT(3), SMPD1(3), SMPD2(1), SPTLC2(2)	5872279	17	16	17	5	3	1	0	8	5	0	0.727	0.993	1.000
354	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(1), ALOX5(2), CBR1(1), CYP4F2(1), CYP4F3(2), EPX(1), GGT1(1), MPO(2), PLA2G4A(1), PLA2G6(1), PRDX6(2), PTGS2(1), TBXAS1(1)	6812195	19	17	19	5	2	0	4	8	5	0	0.575	0.993	1.000
355	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), ASS1(1), CKB(1), CPS1(1), EPRS(2), GLUD2(6), LAP3(2), NOS1(1), NOS3(1), OAT(1), P4HA1(1), PRODH(1), RARS(1), RARS2(2)	8753469	23	21	21	5	2	1	5	11	4	0	0.378	0.993	1.000
356	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(1), ARPC2(1), NCKAP1(1), NTRK1(2), PIR(1), PSMA7(1), WASF1(1)	3695428	9	9	9	6	0	3	0	4	2	0	0.932	0.994	1.000
357	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	BCAR1(1), CTNNA1(3), CTNNA2(1), PTK2(1), PXN(1), SRC(1)	4687079	8	8	8	3	0	1	2	2	3	0	0.735	0.994	1.000
358	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(2), ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP7A(1), ATP7B(2), COX10(3), COX5A(1), COX7A1(1), COX8A(1), NDUFA11(2), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB7(1), NDUFS1(1), NDUFV1(1), SDHA(2)	9258553	27	27	26	7	1	3	3	12	8	0	0.635	0.994	1.000
359	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT2(1)	2588115	1	1	1	0	0	0	0	1	0	0	0.835	0.995	1.000
360	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(1), IL1R1(1), MAP3K1(2), MAP3K7(1), NFKB1(1), NFKBIA(2), RELA(1), TLR4(1), TNF(1), TNFAIP3(2), TNFRSF1B(1)	5923186	14	13	14	5	1	3	1	5	3	1	0.814	0.995	1.000
361	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10B(1), ALG13(1), ALG5(1), ALG6(1), ALG9(1), B4GALT1(1), DPAGT1(2), MGAT2(1), MGAT3(1), MGAT5(1), MGAT5B(1), RFT1(1), RPN1(1), ST6GAL1(1)	10309749	15	12	15	2	1	3	2	2	7	0	0.158	0.995	1.000
362	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(4), EP300(5), IL7R(1), JAK1(2), JAK3(1), PIK3CA(2), PIK3R1(2), STAT5A(1)	6783330	18	17	18	5	1	4	2	5	6	0	0.632	0.995	1.000
363	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(1), H6PD(2), PFKL(1), PFKP(1), PGM1(1), PRPS2(1), RBKS(1), RPE(1), RPIA(1), TKT(1), TKTL2(1)	5898252	12	12	12	4	3	2	1	3	3	0	0.670	0.995	1.000
364	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR2(1), CCR3(2), CCR5(1), CCR7(1), IFNGR1(1), IL12RB1(1), IL4R(1)	4853861	8	7	8	4	0	0	1	4	3	0	0.936	0.995	1.000
365	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(2), ATP4A(1), ATP5A1(1), ATP5B(1), ATP5F1(1), ATP5L(1), ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), COX10(3), COX15(1), COX5A(1), COX7A1(1), COX8A(1), NDUFA11(2), NDUFB10(1), NDUFB11(1), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB7(1), NDUFS1(1), NDUFS3(1), NDUFS6(1), NDUFS7(1), NDUFV1(1), SDHA(2), SDHD(1), TCIRG1(2)	13619031	38	35	37	9	3	4	6	14	11	0	0.381	0.996	1.000
366	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	TNF(1)	3246862	1	1	1	1	0	0	0	0	1	0	1.000	0.996	1.000
367	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), MAP2K2(1), MAP2K3(1), MAP3K1(2), NFKB1(1), PIK3CA(2), PIK3R1(2), RELA(1)	4710753	11	11	11	6	0	3	0	5	3	0	0.981	0.996	1.000
368	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	GNAS(1), GNB1(1), PRKAG2(2), PRKAR2A(1), PRKAR2B(1)	3740886	6	6	6	5	1	0	0	3	2	0	0.963	0.996	1.000
369	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CREBBP(4), GNAS(1), GNB1(1), PRKAR2A(1), PRKAR2B(1), PTPRC(2), ZAP70(1)	5585638	11	10	11	8	1	2	1	3	4	0	0.957	0.996	1.000
370	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CREBBP(4), GNAS(1), GNB1(1), PRKAR2A(1), PRKAR2B(1), PTPRC(2), ZAP70(1)	5585638	11	10	11	8	1	2	1	3	4	0	0.957	0.996	1.000
371	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), IGF1R(1), PIK3CA(2), PIK3R1(2)	3200697	6	6	6	4	0	2	0	3	1	0	0.975	0.997	1.000
372	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	RELN(2), VLDLR(2)	3372780	4	4	4	4	1	1	0	1	1	0	0.987	0.997	1.000
373	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(1), ATM(1), BAD(1), BID(1), CASP9(1), PTK2(1), PXN(1), STAT1(1), TLN1(7), TP53(4)	6626732	20	17	20	6	0	2	4	8	6	0	0.616	0.997	1.000
374	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA1(1), CA13(2), CA6(1), CA9(1), CPS1(1), CTH(1), GLS(2), GLUD2(6), GLUL(2)	5124413	18	18	16	6	0	2	4	9	3	0	0.739	0.997	1.000
375	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(1), BRAF(2), DUSP6(2), EEF2K(3), MAP2K2(1), MAP3K8(1), NFKB1(1), RPS6KA1(1), RPS6KA3(2), SOS1(3), SOS2(1)	7193345	18	18	18	5	0	5	4	4	5	0	0.320	0.997	1.000
376	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(1), AXIN1(2), CREBBP(4), CSNK2A1(2), CTBP1(1), FZD1(2), MAP3K7(1), NLK(1), WIF1(1)	7171725	15	14	15	9	2	2	1	5	4	1	0.962	0.997	1.000
377	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	GNS(1), LCT(3)	3350889	4	4	4	3	1	0	0	2	1	0	0.956	0.998	1.000
378	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	POLR2A(3), PRKAR2A(1), PRKAR2B(1)	3123547	5	5	5	5	2	0	0	2	1	0	0.958	0.998	1.000
379	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(2), PPP1CA(1), PRKAR2A(1), PRKAR2B(1), PRKCE(2)	4286124	7	7	7	4	0	1	0	4	2	0	0.922	0.998	1.000
380	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(1), ASAH1(1), CAMP(1), CERK(1), DAG1(3), ITPKA(1), ITPKB(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1)	6936340	12	11	12	6	2	0	3	2	5	0	0.956	0.998	1.000
381	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(1), EHHADH(1), HADHA(2), PNPLA3(1), YOD1(1)	6258868	6	6	6	2	0	1	0	3	2	0	0.832	0.998	1.000
382	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(1), AGPS(4), CDS2(1), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GPD1(1), LCAT(2), LGALS13(1), PAFAH2(1), PLA2G4A(1), PLA2G6(1), PLCB2(2), PLCG1(1), PLCG2(2)	12263900	30	28	30	7	3	3	3	14	7	0	0.356	0.998	1.000
383	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2B(2), GTF2I(1), GTF2IRD1(1), STON1(1), TAF1(1), TAF10(1), TAF1L(2), TAF2(1), TAF4(2), TAF4B(3), TAF5L(1), TAF6(1), TAF7(1), TBPL2(1)	8742581	20	19	20	5	1	4	6	6	3	0	0.290	0.998	1.000
384	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNB1(1), CCNE1(1), CDKN2A(1)	3888930	3	3	3	2	0	1	1	0	1	0	0.836	0.998	1.000
385	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2B(1), ENPP1(4), ENPP3(1), GAA(1), GBE1(1), GCK(2), GYS2(2), HK1(1), MGAM(3), PGM1(1), PYGB(1), PYGL(1), PYGM(1), SI(2), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1)	13847306	30	25	30	6	5	1	5	13	6	0	0.338	0.998	1.000
386	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(1), AR(3), ASAH1(1), BRAF(2), CAMP(1), DAG1(3), GNA11(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ3(1), MAPK10(1), PHKA2(2), PIK3CA(2), PIK3CD(1), PIK3R1(2), RAF1(2), SRC(1)	12992358	33	30	33	7	1	6	4	12	10	0	0.393	0.998	1.000
387	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOC(1), GCK(2), GMDS(1), GMPPA(1), GMPPB(1), HK1(1), KHK(3), PFKFB3(2), PFKFB4(1), PFKP(1), TPI1(1)	5838795	15	13	15	6	0	1	3	7	4	0	0.891	0.998	1.000
388	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	GNAS(1), GNB1(1), IGF1R(1), ITGB1(2), MAP2K2(1), PDGFRA(1), PTPRR(1), RAF1(2), RPS6KA1(1), SOS1(3), SRC(1)	8076787	15	15	15	4	2	1	1	7	4	0	0.630	0.998	1.000
389	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	PNPLA3(1)	3974463	1	1	1	1	0	1	0	0	0	0	0.889	0.998	1.000
390	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), IL12RB1(1), JAK2(1)	3585113	3	3	3	2	0	0	0	2	1	0	0.955	0.999	1.000
391	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), CRKL(1), MAP2K2(1), MAP2K3(1), MAP3K1(2), PAK1(1), PLCG1(1), RAF1(2), SOS1(3), SRC(1)	6920918	14	13	14	7	0	2	0	7	5	0	0.963	0.999	1.000
392	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(1), AP2A1(1), AP2M1(1), BIN1(1), DNM1(2), EPS15(1), PICALM(2), PPP3CA(1), SYNJ1(1)	5338197	11	10	11	6	1	0	5	2	3	0	0.917	0.999	1.000
393	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG7(1), IFNA16(1), IFNA2(1), INS(1), PIK3C3(1), PIK3R4(1), ULK1(1), ULK2(1)	5139746	8	8	8	4	1	1	0	4	2	0	0.935	0.999	1.000
394	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), MAPK7(3), NTRK1(2), PIK3CA(2), PIK3R1(2), PLCG1(1), RPS6KA1(1)	4660495	12	11	11	6	0	3	1	6	2	0	0.861	0.999	1.000
395	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKB(1), MAP3K1(2), NFKB1(1), NFKBIA(2), RELA(1), TNFAIP3(2)	4416481	9	9	9	4	1	2	0	4	2	0	0.911	0.999	1.000
396	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	F2(1), F2R(1), GNB1(1), MAP3K7(1), PIK3CA(2), PIK3R1(2), PLCB1(1)	6245301	9	9	9	5	1	2	1	2	2	1	0.909	0.999	1.000
397	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(2), CYP2C8(1), CYP3A43(2), CYP3A7(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), RDH11(1), RDH13(1)	5805576	11	10	11	5	0	1	0	7	3	0	0.901	0.999	1.000
398	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), JAK1(2), MAP3K1(2), PDGFRA(1), PIK3CA(2), PIK3R1(2), PLCG1(1), RAF1(2), RASA1(2), SOS1(3), STAT1(1), STAT5A(1)	8446631	21	16	21	7	3	4	0	6	8	0	0.807	0.999	1.000
399	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	AKT1(1), ASAH1(1), GNB1(1), ITGB3(2), PDGFRA(1), PIK3CA(2), PIK3R1(2), PLCB1(1), PTK2(1), SMPD1(3), SMPD2(1), SPHK1(1), SRC(1)	6615447	18	18	18	7	2	4	1	7	4	0	0.832	0.999	1.000
400	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), BAD(1), CASP9(1), NFKB1(1), PIK3CA(2), PIK3R1(2), RAF1(2), RALBP1(1), RELA(1)	4663315	12	11	12	6	0	3	1	5	3	0	0.957	0.999	1.000
401	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH4(1), ADH6(1), AGPAT1(1), AKR1A1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), CEL(2), DGAT1(2), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), LCT(3), LPL(1)	11798312	31	28	31	8	3	3	6	13	6	0	0.427	0.999	1.000
402	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	GNAS(1), PLCE1(1), PRKAR2A(1), PRKAR2B(1)	3589483	4	4	4	5	1	0	1	1	1	0	0.986	0.999	1.000
403	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(3), CAMK1(2), HDAC5(3), IGF1R(1), INS(1), MAPK7(3), NFATC2(3), PIK3CA(2), PIK3R1(2), PPP3CA(1)	8455596	22	21	21	6	4	3	1	11	3	0	0.572	0.999	1.000
404	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), BIRC3(1), CASP1(1), CASP10(1), CASP4(1), CASP9(1)	4669826	6	5	6	5	0	2	0	2	2	0	0.986	0.999	1.000
405	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IKBKB(1), IL1R1(1), IL1RN(1), MAP2K3(1), MAP3K1(2), MAP3K7(1), NFKB1(1), NFKBIA(2), RELA(1), TNF(1)	7191856	12	11	12	6	1	2	0	5	3	1	0.965	0.999	1.000
406	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IKBKB(1), MAP3K1(2), NFKB1(1), NFKBIA(2), RELA(1)	4725646	7	7	7	7	1	1	0	3	2	0	0.999	0.999	1.000
407	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(2), CRY1(1), CSNK1E(3), PER1(1), PER2(2), PER3(1)	4164606	10	10	10	9	3	1	2	3	1	0	0.993	0.999	1.000
408	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	GNS(1), HGSNAT(1), HPSE(1), HYAL1(1), LCT(3), SPAM1(1)	4850685	8	8	8	6	1	0	0	5	2	0	0.974	0.999	1.000
409	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(2), AKT3(2), ASAH1(1), BRAF(2), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ3(1), PI3(1), PIK3CB(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), RAF1(2), RGS20(1), SOS1(3), SOS2(1), SRC(1)	14202557	35	31	35	8	2	5	5	9	14	0	0.338	0.999	1.000
410	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	IKBKB(1), MAP2K3(1), MAP3K1(2), NFKB1(1), NFKBIA(2), RELA(1), TNF(1)	5893079	9	9	9	8	1	1	0	4	3	0	0.999	1.000	1.000
411	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), EGF(1), JAK1(2), MAP3K1(2), PIK3CA(2), PIK3R1(2), PLCG1(1), RAF1(2), RASA1(2), SOS1(3), STAT1(1), STAT5A(1)	9058720	21	17	21	7	2	4	0	7	8	0	0.830	1.000	1.000
412	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), DARS(2), EPRS(2), FARSA(1), IARS2(1), LARS(4), MARS(1), MARS2(1), NARS2(1), RARS(1), RARS2(2), TARS2(2), VARS(2), VARS2(3), YARS2(1)	13114625	26	23	26	5	2	3	3	11	7	0	0.329	1.000	1.000
413	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(3), ATM(1), BRCA1(2), CHEK1(1), MRE11A(1), NFKB1(1), NFKBIA(2), RBBP8(2), RELA(1), TP53(4)	7177486	18	15	18	9	2	1	0	11	4	0	0.948	1.000	1.000
414	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), MAP3K1(2), NFKB1(1), NSMAF(1), RAF1(2), RELA(1), SMPD1(3)	4971115	11	10	11	6	1	2	1	4	3	0	0.966	1.000	1.000
415	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(1), DDX20(3), ETS1(1), HDAC5(3), RBL2(2), SIN3A(2), SIN3B(1)	6450158	13	12	13	7	2	2	1	5	3	0	0.886	1.000	1.000
416	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	GLCE(2), HS2ST1(1), HS3ST2(1), HS3ST3A1(1), HS6ST2(1), NDST3(1)	5058638	7	7	7	3	1	0	1	3	2	0	0.822	1.000	1.000
417	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	ACSM1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HMGCL(2), HSD17B4(1), ILVBL(1), PRDX6(2), RDH11(1), RDH13(1)	9877092	22	22	22	6	1	3	5	10	3	0	0.456	1.000	1.000
418	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), GLI3(2), PRKAR2A(1), PRKAR2B(1), SHH(1), SUFU(2)	4030378	8	7	8	7	0	2	1	3	2	0	0.978	1.000	1.000
419	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), GNB1(1), MAP2K2(1), MAP2K3(1), MAP3K1(2), NFATC2(3), NFATC3(2), NFKB1(1), NFKBIA(2), PAK1(1), PIK3C2G(2), PLCB1(1), PPP3CA(1), RAF1(2), RELA(1)	9321538	23	22	23	7	3	3	1	8	8	0	0.841	1.000	1.000
420	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	LYN(1), MAP3K1(2), NFATC2(3), NFATC3(2), PLCG1(1), PPP3CA(1), RAF1(2), SOS1(3), VAV1(1)	9223530	16	15	16	5	1	2	0	6	7	0	0.856	1.000	1.000
421	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(1), LYN(1), MAP3K1(2), MAPK8IP3(1), PAPPA(3), RPS6KA1(1), RPS6KA3(2), SOS1(3), VAV1(1)	7792610	15	14	15	8	0	4	2	4	5	0	0.934	1.000	1.000
422	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(1), CAPN2(2), EGF(1), ITGA1(3), ITGB1(2), PRKAR2A(1), PRKAR2B(1), PTK2(1), PXN(1), TLN1(7)	7985078	21	18	21	9	0	2	2	11	6	0	0.923	1.000	1.000
423	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BID(1), BIRC3(1), CASP10(1), CASP9(1), GAS2(1), NFKB1(1), NFKBIA(2), RELA(1), SPTAN1(4), TNFRSF25(1), TNFSF10(3)	8154011	18	17	18	8	1	2	3	7	5	0	0.918	1.000	1.000
424	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), CDT1(1), MCM10(2), MCM2(2), MCM3(1), MCM5(1), MCM6(1), MCM7(1), NACA(1), POLD1(1), PRIM1(1), RFC1(1), RFC4(1), RFC5(2), RPA4(1), UBA52(1)	12298582	20	18	20	4	2	2	3	9	4	0	0.392	1.000	1.000
425	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), ETV5(2), IL12RB1(1), JAK2(1)	4530466	5	5	5	3	0	1	0	3	1	0	0.945	1.000	1.000
426	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPS(4), CHPT1(1), PAFAH1B2(1), PAFAH2(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1)	5653895	11	11	11	8	1	2	1	5	2	0	0.970	1.000	1.000
427	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F12(4), F13B(1), F2(1), F5(3), F8(2), LPA(3), PLG(2), SERPINB2(1), VWF(2)	8473457	20	18	20	8	2	2	3	8	5	0	0.897	1.000	1.000
428	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(1), CALCRL(1), CD97(2), ELTD1(2), EMR2(1), GIPR(1), LPHN1(1), LPHN2(1), VIPR2(1)	6566110	11	10	11	5	1	1	3	3	3	0	0.927	1.000	1.000
429	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	AGXT(1), AGXT2(1), ALAS2(2), AOC2(1), AOC3(1), CHDH(1), CTH(1), DLD(2), MAOA(1), MAOB(2), PIPOX(2), PSAT1(1), RDH11(1), RDH13(1), SHMT2(2), TARS2(2)	10239805	22	22	22	8	2	3	2	9	5	1	0.830	1.000	1.000
430	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(1), ATR(3), BRCA1(2), CCNB1(1), CHEK1(1), EP300(5), MYT1(2), PRKDC(2), RPS6KA1(1), TP53(4)	10223912	22	21	22	8	0	3	2	10	7	0	0.834	1.000	1.000
431	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	INS(1), IRS1(1), JAK2(1), PIK3CA(2), PIK3R1(2), PLCG1(1), RAF1(2), RPS6KA1(1), SLC2A4(1), SOS1(3), STAT5A(1)	8012173	16	14	16	6	1	3	1	6	5	0	0.818	1.000	1.000
432	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	FCER1G(1), LYN(1), MAP3K1(2), NFATC2(3), NFATC3(2), PIK3CA(2), PIK3R1(2), PLA2G4A(1), PLCG1(1), PPP3CA(1), RAF1(2), SOS1(3), VAV1(1)	10372563	22	21	22	9	1	4	0	9	8	0	0.937	1.000	1.000
433	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(1), AXIN1(2), CSNK1E(3), FZD1(2), FZD10(1), FZD5(1), FZD7(1), LDLR(1), MAPK10(1), PPP2R5C(2), PPP2R5E(1), PRKCD(2), PRKCE(2), PRKCG(3), PRKCI(3), PRKCQ(1), PRKD1(1), WNT10A(2), WNT10B(1), WNT3(1)	14432597	32	28	32	7	4	4	2	14	8	0	0.313	1.000	1.000
434	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(3), ALDH1B1(2), ALDH2(2), ALDH3A2(2), DLD(2), LDHB(1), MDH1(1), ME2(1), PC(5), PCK1(1)	8938640	20	18	20	7	1	2	7	5	4	1	0.718	1.000	1.000
435	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), MAP2K2(1), MAP3K1(2), PAK1(1), PTK2(1), RAF1(2), SOS1(3), SRC(1)	8159348	14	13	14	7	0	3	1	5	5	0	0.927	1.000	1.000
436	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC10(1), ANAPC4(1), ANAPC5(2), CDC16(1), CDC20(2), CUL1(2), CUL2(1), FBXW11(1), FBXW7(2), UBA1(1), VHL(2), WWP1(6), WWP2(1)	9003487	23	20	23	7	3	2	4	8	6	0	0.713	1.000	1.000
437	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(1), AKT2(2), AKT3(2), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), PHKA2(2), PIK3CB(1)	10948352	26	25	26	7	4	3	4	9	6	0	0.413	1.000	1.000
438	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKB(1), MAP3K1(2), NFKB1(1), NFKBIA(2), RELA(1), TNFAIP3(2), TNFRSF1B(1)	5453860	10	10	10	5	1	3	0	4	2	0	0.933	1.000	1.000
439	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(3), ATM(1), ATR(3), CCNE1(1), CDKN2A(1), TP53(4)	7298237	13	12	13	8	1	1	1	7	3	0	0.957	1.000	1.000
440	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), AKT1(1), DAG1(3), DGKA(1), GCA(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), PAK1(1), PDE3B(2), PI3(1), PIK3C2G(2), PIK3CA(2), PIK3CD(1), PIK3R1(2)	11870726	26	25	26	6	0	7	2	11	6	0	0.518	1.000	1.000
441	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(1), MAP3K1(2)	4232955	3	3	3	7	0	1	0	1	1	0	1.000	1.000	1.000
442	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	LIMK1(2), MAP3K1(2), PAK1(1), PDGFRA(1), PIK3CA(2), PIK3R1(2), RALBP1(1), TRIO(6), VAV1(1), WASF1(1)	8462840	19	18	19	8	2	5	1	6	5	0	0.888	1.000	1.000
443	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACMSD(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), AOC2(1), AOC3(1), CYP1B1(1), EHHADH(1), HAAO(1), HADHA(2), HSD17B4(1), KYNU(1), LNX1(1), MAOA(1), MAOB(2), METTL2B(1), NFX1(2), OGDH(5), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1), TPH2(1)	14680834	35	28	35	8	3	6	5	13	8	0	0.228	1.000	1.000
444	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(2), CD1C(1), CD36(1), CD59(1), CR2(1), CSF1R(1), CSF2RA(1), CSF3R(1), EPOR(2), FCER2(1), FCGR1A(2), GP9(1), IL1R1(1), IL1R2(2), IL4R(1), IL5RA(2), IL7R(1), IL9R(3), ITGA1(3), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGAM(3), ITGB3(2), TFRC(1), THPO(1), TNF(1)	19875860	42	36	42	9	4	3	4	19	12	0	0.441	1.000	1.000
445	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSD(1), ARSE(1), CYP11B1(1), HSD17B7(1), METTL2B(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1), SRD5A1(1), SULT1E1(2), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UGT2A3(1), UGT2B17(1), UGT2B28(1), UGT2B7(1)	12110428	21	19	21	8	1	0	5	6	9	0	0.795	1.000	1.000
446	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), BCAR1(1), BCR(1), CAPN1(1), CRKL(1), ITGA1(3), ITGB1(2), MAP2K2(1), PTK2(1), PXN(1), RAF1(2), SOS1(3), SRC(1), TLN1(7)	11484977	26	24	26	8	0	3	2	12	9	0	0.794	1.000	1.000
447	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC3(1), MAP3K7(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), RALBP1(1), TNF(1), TNFAIP3(2), TNFRSF1B(1)	6648870	13	12	13	6	2	3	0	6	1	1	0.821	1.000	1.000
448	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(3), DCK(1), DPYD(1), DPYS(2), ENTPD1(1), POLB(1), POLD1(1), POLG(2), POLQ(5), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLRMT(2), TK2(1), TXNRD1(2), TYMS(1)	13987082	33	30	33	8	3	4	5	11	10	0	0.513	1.000	1.000
449	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(2), APC(1), AXIN1(2), FZD1(2), NOTCH1(5)	5221564	12	12	12	5	2	3	0	6	1	0	0.777	1.000	1.000
450	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(3), ACACB(1), ACSS1(1), ALDH1B1(2), ALDH2(2), ALDH3A2(2), DLD(2), LDHB(1), MDH1(1), ME2(1), PC(5), PCK1(1), PCK2(1)	11313483	23	21	23	8	1	3	7	5	6	1	0.730	1.000	1.000
451	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), GNB1(1), NFKB1(1), PIK3C2G(2), PIK3CA(2), PIK3R1(2), PLCG1(1), PTK2(1), PXN(1), RAF1(2), RELA(1)	6770487	15	14	15	7	0	4	1	6	4	0	0.937	1.000	1.000
452	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(1), PGAP1(5), PIGB(1), PIGN(1), PIGQ(1)	5866760	9	9	9	4	0	3	0	4	2	0	0.755	1.000	1.000
453	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(1), ARSE(1), ASAH1(1), CERK(1), GAL3ST1(1), GALC(2), GBA(1), LCT(3), SGMS1(1), SMPD1(3), SMPD2(1), SMPD4(2), SPHK1(1), SPTLC2(2)	8689615	22	19	22	7	3	3	1	10	5	0	0.660	1.000	1.000
454	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	AKT1(1), AURKB(1), BMPR1A(1), BUB1(1), CDKL2(3), CDS2(1), CLK1(1), CLK4(2), COL4A3BP(1), CSNK2A1(2), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), INPP4B(2), INPPL1(2), ITPKA(1), ITPKB(1), MAP3K10(1), OCRL(1), PAK4(1), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3CA(2), PIK3CB(1), PIK3CG(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), PLCD1(2), PLCG1(1), PLCG2(2), PRKACA(1), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(3), PRKCQ(1), PRKD1(1), PRKG1(1), RAF1(2), RPS6KA1(1), RPS6KA3(2), RPS6KA4(1), STK11(2), TGFBR1(1), VRK1(1)	27598330	79	63	79	14	7	13	7	29	23	0	0.0454	1.000	1.000
455	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	GNAS(1), GNB1(1), NFATC2(3), NFATC3(2), PLCG1(1), PPP3CA(1), PRKAR2A(1), PRKAR2B(1), RAF1(2), RPS6KA3(2)	8464193	15	15	15	9	2	1	1	6	5	0	0.979	1.000	1.000
456	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	DCXR(1), RPE(1), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UGT2A3(1), UGT2B17(1), UGT2B28(1), UGT2B7(1)	6540850	11	11	11	5	0	1	4	4	2	0	0.864	1.000	1.000
457	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), EEF2K(3), IL1R1(1), MAP2K3(1), MAP3K10(1), MAP3K4(1), MAP3K7(1), MYEF2(1), NFKB1(1)	8144194	11	10	11	8	0	3	0	5	2	1	0.967	1.000	1.000
458	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(1), AXIN1(2), CREBBP(4), EP300(5), FZD1(2), LDB1(1), LEF1(1)	8021683	16	15	16	7	1	2	2	7	4	0	0.890	1.000	1.000
459	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(1), ASAH1(1), CAMP(1), DAG1(3), DLG4(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ3(1), RYR1(7)	11186250	22	22	22	6	4	2	5	7	4	0	0.517	1.000	1.000
460	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), CCNB1(1), GNAS(1), GNB1(1), MYT1(2), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1), SRC(1)	5015509	10	10	10	8	1	2	2	4	1	0	0.968	1.000	1.000
461	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP5(2), ARHGEF5(1), ARPC2(1), BAIAP2(1), DIAPH1(2), GSN(2), LIMK1(2), PIP5K1B(1), SRC(1), TLN1(7)	11143687	21	18	21	6	1	3	3	7	7	0	0.638	1.000	1.000
462	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	AGXT(1), AGXT2(1), ALAS2(2), AOC2(1), AOC3(1), CHDH(1), CTH(1), DLD(2), MAOA(1), MAOB(2), PLCB2(2), PLCG1(1), PLCG2(2), SHMT2(2)	10067950	20	20	20	6	3	2	2	9	3	1	0.648	1.000	1.000
463	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(1), COL4A3(2), COL4A4(1), COL4A5(1), COL4A6(3), F10(1), F12(4), F2(1), F2R(1), F5(3), F8(2), PROS1(1)	10807039	22	20	22	8	1	2	4	10	5	0	0.760	1.000	1.000
464	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	IKBKB(1), MAP2K3(1), MAP3K1(2), MAP3K7(1), NFKB1(1), NFKBIA(2), RELA(1), TLR10(1), TLR3(1), TLR4(1), TLR6(1), TLR7(1)	8831194	14	13	14	7	1	1	1	8	2	1	0.949	1.000	1.000
465	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CDC40(1), CLK3(1), CLK4(2), CPSF1(1), CPSF3(1), CSTF2T(1), DDX20(3), DHX16(1), DHX38(3), DHX9(3), DICER1(1), GIPC1(1), POLR2A(3), PRPF18(2), PRPF4B(4), PRPF8(3), RBM17(2), RBM5(1), RNMT(2), RNPS1(1), SF3A1(1), SF3B2(3), SF3B4(1), SNRPE(1), SRRM1(3), SUPT5H(3), U2AF2(1), XRN2(1)	25035062	51	42	51	8	6	8	5	21	11	0	0.134	1.000	1.000
466	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ACAD9(1), ADH4(1), ADH6(1), PNPLA3(1)	6007087	6	6	6	3	0	2	0	4	0	0	0.859	1.000	1.000
467	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT1(1), GAA(1), GCK(2), HK1(1), LCT(3), MGAM(3), PFKP(1), PGM1(1)	7941793	13	12	13	7	3	0	0	6	4	0	0.985	1.000	1.000
468	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(1), AXIN1(2), BMP7(1), BMPR1A(1), CHRD(1), FZD1(2), MAP3K7(1), NKX2-5(3), NOG(1), RFC1(1), TGFBR1(1), TGFBR2(1)	8825974	16	15	16	8	3	1	0	9	2	1	0.934	1.000	1.000
469	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH4(1), ADH6(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), HGD(1), HPD(2), MAOA(1), MAOB(2)	7697629	12	12	12	5	3	1	0	6	2	0	0.784	1.000	1.000
470	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(3), EPRS(2), HMOX1(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UROD(1)	6609167	11	11	11	6	0	1	4	5	1	0	0.906	1.000	1.000
471	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(1), CAMK2A(1), CLCA1(1), CNGA3(1), CNGA4(1), GUCA1B(1), PDE1C(1), PRKACA(1), PRKG1(1), PRKG2(1), PRKX(1)	7427894	14	14	14	9	3	1	1	7	2	0	0.935	1.000	1.000
472	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH4(1), ADH6(1), AKR1A1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH3B1(1), ALDH3B2(1), ALDOC(1), DLD(2), GAPDH(2), GCK(2), HK1(1), LDHB(1), PFKP(1), PGM1(1), TPI1(1)	11807752	24	22	24	9	3	1	7	7	5	1	0.771	1.000	1.000
473	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH4(1), ADH6(1), AKR1A1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH3B1(1), ALDH3B2(1), ALDOC(1), DLD(2), GAPDH(2), GCK(2), HK1(1), LDHB(1), PFKP(1), PGM1(1), TPI1(1)	11807752	24	22	24	9	3	1	7	7	5	1	0.771	1.000	1.000
474	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOC(1), GMDS(1), GMPPA(1), GMPPB(1), HK1(1), KHK(3), MTMR2(2), MTMR6(1), PFKFB3(2), PFKFB4(1), PFKL(1), PFKP(1), PHPT1(1), RDH11(1), RDH13(1), TPI1(1)	9108745	20	19	20	9	0	4	4	8	4	0	0.866	1.000	1.000
475	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(1), AXIN1(2), FZD1(2), LEF1(1), NFKB1(1), PIK3CA(2), PIK3R1(2), RELA(1), TLR4(1)	7437366	14	13	14	9	1	2	1	8	2	0	0.987	1.000	1.000
476	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(1), CAMK2A(1), F2(1), GNA11(1), GNB1(1), JAK2(1), MAP2K2(1), PLCG1(1), RAF1(2), SOS1(3), STAT1(1), STAT5A(1)	10160872	18	16	18	7	1	2	0	10	5	0	0.865	1.000	1.000
477	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(1), AP2M1(1), BAD(1), EEA1(1), GSK3A(1), LYN(1), PFKL(1), PFKP(1), PLCG1(1), PRKCE(2)	6023795	12	12	12	7	0	1	4	6	1	0	0.970	1.000	1.000
478	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	BTG1(1), CBX3(1), CLOCK(2), CRY1(1), EIF4G2(1), GSTP1(2), HERPUD1(2), HSPA8(1), NCKAP1(1), NCOA4(2), NR1D2(1), PER1(1), PER2(2), PPP2CB(1), TOB1(3), ZFR(1)	8897726	23	20	23	8	1	2	5	11	4	0	0.826	1.000	1.000
479	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(2), AR(3), ESR2(1), ESRRA(1), HNF4A(2), NR1D2(1), NR2E1(1), NR2F1(1), NR2F2(2), NR2F6(1), NR3C1(2), PGR(1), RARG(1), RORC(1)	10254921	20	19	20	6	2	3	3	11	1	0	0.623	1.000	1.000
480	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(1), BMPR1B(1), DAZL(1), ESR2(1), MLH1(1), NCOR1(3), PGR(1), PRLR(1), SMPD1(3), ZP2(3)	8437678	16	14	16	6	1	4	1	8	2	0	0.727	1.000	1.000
481	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(3), ADCY9(2), ARF3(1), ARF5(1), ATP6V0A4(1), ATP6V1A(1), GNAS(1), PLCG1(1), PLCG2(2), SEC61B(1), TRIM23(2)	8996297	17	16	17	8	4	0	1	9	3	0	0.852	1.000	1.000
482	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(1), ATM(1), ATR(3), BAI1(2), BID(1), CASP9(1), CCNB1(1), CCNB2(1), CCNE1(1), CCNE2(1), CCNG1(1), CCNG2(1), CDKN2A(1), CHEK1(1), GADD45B(1), GTSE1(2), PPM1D(2), PTEN(5), RCHY1(2), RFWD2(1), SERPINB5(1), SESN1(1), SFN(1), THBS1(4), TP53(4), TSC2(4), ZMAT3(1)	15880604	46	40	46	10	3	6	10	12	15	0	0.180	1.000	1.000
483	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	FUCA1(2), GBA(1), GNS(1), HGSNAT(1), HPSE(1), HYAL1(1), LCT(3), MAN2B1(1), MANBA(1), SPAM1(1)	8303799	13	12	13	7	2	0	1	8	2	0	0.914	1.000	1.000
484	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH4(1), ADH6(1), AGK(1), AGPAT1(1), AKR1A1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), CEL(2), DAK(1), DGAT1(2), DGAT2(1), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), GPAM(2), LCT(3), LIPA(1), LPL(1), PNPLA3(1)	14344541	38	35	38	10	3	4	7	16	8	0	0.393	1.000	1.000
485	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(1), BID(1), BRAF(2), FASLG(2), FCER1G(1), HLA-A(1), HLA-B(2), HLA-C(1), ICAM1(1), IFNA16(1), IFNA2(1), IFNAR1(1), IFNGR1(1), ITGAL(2), ITGB2(1), KIR3DL2(1), KLRC1(1), KLRC3(1), KLRK1(3), KRAS(2), LCP2(2), MAP2K2(1), MICB(1), NCR2(1), NFAT5(1), NFATC2(3), NFATC3(2), NRAS(1), PAK1(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLCG1(1), PLCG2(2), PPP3CA(1), PRKCG(3), PTPN11(1), RAC2(1), RAF1(2), SH3BP2(4), SHC2(3), SHC4(1), SOS1(3), SOS2(1), TNF(1), TNFSF10(3), ULBP1(2), VAV1(1), ZAP70(1)	27511039	80	58	79	15	3	13	10	31	22	1	0.0659	1.000	1.000
486	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(1), ATR(3), BRCA1(2), BRCA2(5), CHEK1(1), FANCA(1), FANCG(1), MRE11A(1), TP53(4), TREX1(1)	10612737	20	17	20	7	0	2	3	12	3	0	0.731	1.000	1.000
487	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT2(2), AKT3(2), CARD11(2), CBL(1), CBLB(1), CBLC(1), CTLA4(2), ICOS(1), IKBKB(1), KRAS(2), LCP2(2), MALT1(1), MAP3K8(1), NCK2(1), NFAT5(1), NFATC2(3), NFATC3(2), NFKB1(1), NFKB2(2), NFKBIA(2), NRAS(1), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PDCD1(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLCG1(1), PPP3CA(1), PRKCQ(1), PTPRC(2), RASGRP1(1), SOS1(3), SOS2(1), TNF(1), VAV1(1), ZAP70(1)	24613187	61	49	60	11	5	10	9	23	14	0	0.0575	1.000	1.000
488	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPL(1), ALPP(1), ALPPL2(1), ASCC3(1), ATP13A2(2), DDX23(1), DDX4(1), DDX41(3), DDX47(2), DDX50(2), DDX51(1), DDX52(1), DDX54(1), DDX56(1), DHX58(1), ENTPD7(3), EP400(5), ERCC3(3), IFIH1(2), NUDT5(1), RAD54B(1), RUVBL2(1), SETX(2), SKIV2L2(1), SMARCA5(2)	15223548	42	38	42	10	2	6	9	22	3	0	0.255	1.000	1.000
489	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH4(1), ADH6(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), HGD(1), HPD(2), MAOA(1), MAOB(2), METTL2B(1), PNPLA3(1), PRMT2(2), PRMT5(1), PRMT6(1), PRMT7(1), TYRP1(2)	14395058	21	19	21	7	3	2	1	9	6	0	0.647	1.000	1.000
490	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT2(2), AKT3(2), APC(1), AXIN1(2), GSK3A(1), LRP1(1), MVP(1), NKD1(2), NKD2(2), PTPRA(1), WIF1(1)	9842146	17	17	17	6	2	2	2	9	2	0	0.684	1.000	1.000
491	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(3), ABL2(1), AKT1(1), AKT2(2), AKT3(2), ARAF(1), BAD(1), BRAF(2), BTC(1), CAMK2A(1), CBL(1), CBLB(1), CBLC(1), CRKL(1), EGF(1), EIF4EBP1(1), ERBB2(3), ERBB3(1), ERBB4(3), GAB1(1), KRAS(2), MAP2K2(1), MAPK10(1), NCK2(1), NRAS(1), NRG1(2), NRG2(1), NRG3(3), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLCG1(1), PLCG2(2), PRKCG(3), PTK2(1), RAF1(2), SHC2(3), SHC4(1), SOS1(3), SOS2(1), SRC(1), STAT5A(1), TGFA(1)	25068808	75	55	74	15	5	12	13	32	13	0	0.0715	1.000	1.000
492	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(3), ASH2L(1), CTCFL(3), DOT1L(6), EED(1), EHMT1(1), EHMT2(3), EZH1(1), FBXO11(3), KDM6A(7), NSD1(5), OGT(1), PAXIP1(3), PPP1CA(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRDM9(2), PRMT5(1), PRMT6(1), PRMT7(1), RBBP5(1), SATB1(2), SETD1A(3), SETD2(11), SETDB1(2), SUV39H2(1), SUV420H1(1), SUZ12(1), WHSC1(1)	29461631	71	53	71	13	5	8	8	21	28	1	0.177	1.000	1.000
493	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(1), CCNB1(1), CCNE1(1), CCNE2(1), CCNG2(1), CDKN2A(1), CREB3L3(1), E2F2(1), E2F3(1), GBA2(1), MCM2(2), MCM3(1), MCM5(1), MCM6(1), MCM7(1), MYT1(2), NACA(1), PRIM1(1), TNXB(5), TP53(4)	18732408	29	28	29	8	4	3	5	12	5	0	0.320	1.000	1.000
494	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(2), AKT3(2), BAD(1), BCR(1), CD81(1), CR2(1), DAG1(3), GSK3A(1), ITPR1(2), ITPR2(3), ITPR3(1), LYN(1), MAP4K1(2), NFATC2(3), PIK3CA(2), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP3CA(1), PTPRC(2), RAF1(2), SOS1(3), SOS2(1), VAV1(1)	17908774	42	37	42	10	2	6	6	15	13	0	0.440	1.000	1.000
495	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(2), CACNA1A(5), GNA11(1), GNAI2(1), GNAI3(1), GNAS(1), GNAZ(1), GRIA1(2), GRID2(3), GRM5(1), GUCY1B3(2), GUCY2C(2), GUCY2D(2), IGF1R(1), ITPR1(2), ITPR2(3), ITPR3(1), KRAS(2), LYN(1), MAP2K2(1), NOS1(1), NOS3(1), NPR2(1), NRAS(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PRKCG(3), PRKG1(1), PRKG2(1), RAF1(2), RYR1(7)	26922891	68	54	67	14	10	9	10	25	14	0	0.107	1.000	1.000
496	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(1), AVPR2(1), C3AR1(2), CCKAR(1), CCKBR(2), CCR2(1), CCR3(2), CCR5(1), CCR7(1), GRPR(1), NPY2R(1), NTSR1(1), SSTR1(2), SSTR3(1), SSTR4(2), TACR2(1)	12559248	21	19	21	8	2	3	3	10	3	0	0.702	1.000	1.000
497	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG10B(1), ALG13(1), ALG6(1), ALG9(1), B3GNT1(1), B3GNT6(3), B4GALT1(1), CHPF(1), CHST2(1), CHST3(1), CHST6(1), CHST7(1), DPAGT1(2), FUT11(2), GALNT10(2), GALNT11(1), GALNT14(1), GALNT2(1), GALNT4(1), GALNT5(1), GALNT6(2), GALNT7(1), GALNTL5(1), GCNT3(2), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST3A1(1), HS6ST2(1), MGAT2(1), MGAT3(1), MGAT5(1), MGAT5B(1), NDST3(1), OGT(1), RPN1(1), ST3GAL4(1), ST6GAL1(1), UST(1), WBSCR17(1), XYLT1(2)	26809766	50	40	49	10	6	7	9	12	16	0	0.0876	1.000	1.000
498	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(2), AKT3(2), BAD(1), CASP9(1), KDR(1), KRAS(2), MAP2K2(1), NFAT5(1), NFATC2(3), NFATC3(2), NOS3(1), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PLCG1(1), PLCG2(2), PPP3CA(1), PRKCG(3), PTGS2(1), PTK2(1), PXN(1), RAC2(1), RAF1(2), SHC2(3), SPHK1(1), SRC(1)	17592569	49	39	48	12	3	7	8	19	12	0	0.449	1.000	1.000
499	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR2A(3), AMH(1), AMHR2(2), BMP7(1), BMPR1A(1), BMPR1B(1), CCR2(1), CCR3(2), CCR5(1), CCR7(1), CD27(2), CD40(1), CNTF(1), CSF1R(1), CSF2RA(1), CSF2RB(1), CSF3R(1), CX3CL1(2), CXCL1(1), EDA(1), EGF(1), EPOR(2), FASLG(2), FLT1(1), FLT4(3), GDF5(2), IFNA16(1), IFNA2(1), IFNAR1(1), IFNGR1(1), IL10RA(4), IL12RB1(1), IL15RA(1), IL17RB(2), IL1R1(1), IL1R2(2), IL21R(2), IL22RA1(2), IL4R(1), IL5RA(2), IL6ST(3), IL7R(1), IL9(1), IL9R(3), INHBB(1), KDR(1), LEPR(1), LIFR(3), OSM(1), PDGFRA(1), PDGFRB(2), PRLR(1), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF19(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFSF10(3), TNFSF15(1), TNFSF8(1)	42401123	93	72	93	19	7	12	15	36	23	0	0.119	1.000	1.000
500	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP4B(2), INPP5B(2), INPP5E(1), INPPL1(2), ITPK1(1), ITPKA(1), ITPKB(1), MINPP1(1), OCRL(1), PI4KA(1), PIK3C3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIP4K2A(2), PIP5K1B(1), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), PLCD1(2), PLCE1(1), PLCG1(1), PLCG2(2), PLCZ1(1), PTEN(5), SYNJ1(1)	18088391	42	37	41	11	3	5	8	13	13	0	0.477	1.000	1.000
501	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GNT1(1), B4GALNT1(1), B4GALT1(1), FUT2(1), FUT4(1), FUT6(1), FUT7(1), PIGB(1), PIGN(1), PIGQ(1), ST3GAL4(1), ST6GALNAC5(2)	11837878	13	12	13	6	1	3	0	8	1	0	0.807	1.000	1.000
502	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(2), AKT3(2), BRAF(2), EIF4B(2), EIF4EBP1(1), HIF1A(1), INS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), RHEB(1), RICTOR(3), RPS6KA1(1), RPS6KA3(2), STK11(2), TSC1(2), TSC2(4), ULK1(1), ULK2(1)	12971411	38	35	38	11	4	10	6	10	7	1	0.330	1.000	1.000
503	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(3), AMY2B(1), ASCC3(1), ATP13A2(2), DDX23(1), DDX4(1), DDX41(3), DDX47(2), DDX50(2), DDX51(1), DDX52(1), DDX54(1), DDX56(1), DHX58(1), ENPP1(4), ENPP3(1), ENTPD7(3), EP400(5), ERCC3(3), GAA(1), GBA(1), GBE1(1), GCK(2), GYS2(2), HK1(1), IFIH1(2), MGAM(3), NUDT5(1), PGM1(1), PYGB(1), PYGL(1), PYGM(1), RAD54B(1), RUVBL2(1), SETX(2), SI(2), SKIV2L2(1), SMARCA5(2), UGDH(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UGT2A3(1), UGT2B17(1), UGT2B28(1), UGT2B7(1)	29986222	73	55	73	16	6	5	13	39	10	0	0.230	1.000	1.000
504	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(1), AKT2(2), AKT3(2), CBL(1), CBLB(1), CBLC(1), CISH(2), CNTF(1), CREBBP(4), CSF2RA(1), CSF2RB(1), CSF3R(1), EP300(5), EPOR(2), IFNA16(1), IFNA2(1), IFNAR1(1), IFNGR1(1), IL10RA(4), IL12RB1(1), IL15RA(1), IL21R(2), IL22RA1(2), IL4R(1), IL5RA(2), IL6ST(3), IL7R(1), IL9(1), IL9R(3), JAK1(2), JAK2(1), JAK3(1), LEPR(1), LIFR(3), OSM(1), PIAS1(1), PIAS2(1), PIAS3(1), PIAS4(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PRLR(1), PTPN11(1), SOCS5(1), SOS1(3), SOS2(1), SPRED2(1), SPRY2(1), STAM(2), STAT1(1), STAT2(1), STAT5A(1), STAT6(1)	35251528	87	64	87	17	6	14	14	30	23	0	0.0846	1.000	1.000
505	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(2), AKT3(2), BCR(1), CDKN2A(1), DAPP1(2), GAB1(1), ITPR1(2), ITPR2(3), ITPR3(1), LYN(1), PHF11(1), PIK3CA(2), PLCG2(2), PREX1(1), PTEN(5), PTPRC(2), RPS6KA1(1), RPS6KA3(2), VAV1(1)	13441467	34	30	34	10	1	5	6	10	12	0	0.477	1.000	1.000
506	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ADH4(1), ADH6(1), AKR1A1(2), ALDH1B1(2), ALDH2(2), ALDH3A2(2), ALDH3B1(1), ALDH3B2(1), ALDOC(1), DLD(2), GALM(1), GAPDH(2), GAPDHS(2), GCK(2), HK1(1), LDHB(1), PFKL(1), PFKP(1), PGAM2(1), PGK2(1), PGM1(1), TPI1(1)	14089883	31	29	31	10	3	2	7	10	8	1	0.658	1.000	1.000
507	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(1), APC2(1), AXIN1(2), CACYBP(1), CAMK2A(1), CHD8(3), CREBBP(4), CSNK1E(3), CSNK2A1(2), CTBP1(1), CUL1(2), DAAM1(1), EP300(5), FBXW11(1), FZD1(2), FZD10(1), FZD4(1), FZD5(1), FZD7(1), LEF1(1), LRP5(3), LRP6(4), MAP3K7(1), MAPK10(1), NFAT5(1), NFATC2(3), NFATC3(2), NKD1(2), NKD2(2), NLK(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), PORCN(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PPP3CA(1), PRICKLE1(1), PRICKLE2(1), PRKACA(1), PRKCG(3), PRKX(1), RAC2(1), ROCK2(1), SFRP5(2), SMAD4(2), TBL1X(1), TBL1XR1(2), TCF7L1(1), TP53(4), VANGL1(3), WIF1(1), WNT10A(2), WNT10B(1), WNT3(1), WNT8A(1), WNT8B(1)	39249468	99	74	99	23	9	12	14	35	28	1	0.165	1.000	1.000
508	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), C1S(1), C3(1), C3AR1(2), C4BPB(1), C5AR1(1), C6(2), C7(1), CD46(1), CD59(1), CFB(1), CFD(1), CFH(1), CFI(1), CPB2(1), CR2(1), F10(1), F12(4), F13A1(2), F13B(1), F2(1), F2R(1), F5(3), F8(2), KNG1(2), MASP1(1), MBL2(1), PLG(2), PROS1(1), SERPINA1(1), SERPIND1(1), TFPI(1), THBD(1), VWF(2)	21931057	47	39	47	13	5	5	4	26	7	0	0.642	1.000	1.000
509	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR2A(3), AMH(1), AMHR2(2), BMP7(1), BMP8A(1), BMPR1A(1), BMPR1B(1), CHRD(1), CREBBP(4), CUL1(2), EP300(5), GDF5(2), INHBB(1), LEFTY1(1), LTBP1(5), NODAL(1), NOG(1), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), RBL2(2), ROCK2(1), SMAD1(1), SMAD4(2), SMAD6(1), SMAD7(1), TGFBR1(1), TGFBR2(1), THBS1(4), THBS2(2), THBS3(1), TNF(1), ZFYVE9(1)	24027586	58	46	57	16	6	9	14	16	13	0	0.365	1.000	1.000
510	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDS2(1), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), INPP4B(2), INPP5B(2), INPP5E(1), INPPL1(2), ITPK1(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), OCRL(1), PI4KA(1), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3C3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PIP4K2A(2), PIP5K1B(1), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), PLCD1(2), PLCE1(1), PLCG1(1), PLCG2(2), PLCZ1(1), PRKCG(3), PTEN(5), SYNJ1(1)	30492909	74	60	73	18	4	13	11	27	19	0	0.268	1.000	1.000
511	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT2(2), AKT3(2), CARD11(2), CD81(1), CR2(1), IFITM1(1), IKBKB(1), KRAS(2), LYN(1), MALT1(1), NFAT5(1), NFATC2(3), NFATC3(2), NFKB1(1), NFKB2(2), NFKBIA(2), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLCG2(2), PPP3CA(1), RAC2(1), RASGRP3(1), VAV1(1)	18092723	42	37	41	12	4	5	4	21	8	0	0.564	1.000	1.000
512	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(2), AKT3(2), FCER1G(1), GAB2(1), KRAS(2), LCP2(2), LYN(1), MAP2K2(1), MAP2K3(1), MAPK10(1), NRAS(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PLCG1(1), PLCG2(2), PRKCD(2), PRKCE(2), RAC2(1), RAF1(2), SOS1(3), SOS2(1), TNF(1), VAV1(1)	17462760	44	39	43	13	2	9	4	20	9	0	0.523	1.000	1.000
513	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTG1(1), AKT1(1), AKT2(2), AKT3(2), ARHGAP5(2), BAD(1), BCAR1(1), BIRC3(1), BRAF(2), CAPN2(2), CAV2(1), CHAD(1), COL11A1(1), COL11A2(1), COL1A1(3), COL1A2(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(1), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(4), CRKL(1), DIAPH1(2), DOCK1(2), EGF(1), ERBB2(3), FARP2(1), FLNA(1), FLNB(2), FLNC(4), FLT1(1), FN1(4), IGF1R(1), ITGA1(3), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGA7(1), ITGA8(2), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(4), ITGB7(1), KDR(1), LAMA2(2), LAMA3(2), LAMA4(2), LAMA5(3), LAMB1(7), LAMB2(3), LAMB3(3), LAMB4(1), LAMC3(1), MAPK10(1), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PARVG(1), PDGFD(1), PDGFRA(1), PDGFRB(2), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PIP5K1C(2), PPP1CA(1), PPP1CC(1), PPP1R12A(1), PRKCG(3), PTEN(5), PTK2(1), PXN(1), RAC2(1), RAF1(2), RAPGEF1(1), RELN(2), ROCK2(1), SHC2(3), SHC4(1), SOS1(3), SOS2(1), SRC(1), THBS1(4), THBS2(2), THBS3(1), TLN1(7), TLN2(3), TNC(3), TNR(1), TNXB(5), VAV1(1), VWF(2)	89771519	202	109	202	54	10	22	33	83	53	1	0.352	1.000	1.000
514	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	APC(1), APC2(1), ARAF(1), ARHGEF12(3), ARHGEF4(2), ARHGEF6(2), ARHGEF7(1), ARPC2(1), BAIAP2(1), BCAR1(1), BRAF(2), CFL2(1), CHRM1(2), CHRM2(2), CHRM3(1), CRKL(1), CYFIP1(1), CYFIP2(1), DIAPH1(2), DIAPH3(2), DOCK1(2), EGF(1), EZR(1), F2(1), F2R(1), FGF1(2), FGF10(1), FGF12(1), FGF19(1), FGF21(1), FGF3(3), FGF6(1), FGFR1(1), FGFR3(6), FN1(4), GIT1(1), GNG12(1), GSN(2), INS(1), IQGAP1(1), IQGAP2(4), IQGAP3(1), ITGA1(3), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGA7(1), ITGA8(2), ITGAD(2), ITGAE(1), ITGAL(2), ITGAM(3), ITGAX(4), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(4), ITGB5(4), ITGB7(1), KRAS(2), LIMK1(2), LIMK2(2), MAP2K2(1), MSN(1), MYH10(1), MYH14(1), MYH9(2), NCKAP1(1), NCKAP1L(2), NRAS(1), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PDGFRA(1), PDGFRB(2), PFN3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PIP4K2A(2), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PPP1CC(1), PPP1R12A(1), PTK2(1), PXN(1), RAC2(1), RAF1(2), RDX(1), ROCK2(1), SCIN(2), SOS1(3), SOS2(1), SSH2(4), TIAM1(1), VAV1(1), WASF1(1)	67723155	169	101	167	41	16	28	19	72	34	0	0.0840	1.000	1.000
515	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	AKT1(1), AKT2(2), AKT3(2), ARRB1(2), BDNF(1), BRAF(2), CACNA1A(5), CACNA1C(5), CACNA1D(2), CACNA1G(2), CACNA1H(2), CACNA1I(3), CACNA1S(5), CACNA2D1(1), CACNA2D4(1), CACNB1(2), CACNB4(1), CACNG2(2), CACNG4(1), CACNG8(1), CRKL(1), DAXX(1), DUSP6(2), ECSIT(1), EGF(1), FASLG(2), FGF1(2), FGF10(1), FGF12(1), FGF19(1), FGF21(1), FGF3(3), FGF6(1), FGFR1(1), FGFR3(6), FLNA(1), FLNB(2), FLNC(4), GADD45B(1), GNG12(1), IKBKB(1), IL1R1(1), IL1R2(2), KRAS(2), MAP2K2(1), MAP2K3(1), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K4(1), MAP3K6(1), MAP3K7(1), MAP3K8(1), MAP4K1(2), MAP4K3(2), MAPK10(1), MAPK7(3), MAPK8IP1(1), MAPK8IP3(1), NF1(2), NFATC2(3), NFKB1(1), NFKB2(2), NLK(1), NRAS(1), NTRK1(2), NTRK2(1), PAK1(1), PDGFRA(1), PDGFRB(2), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PPM1A(2), PPP3CA(1), PRKACA(1), PRKCG(3), PRKX(1), PTPRR(1), RAC2(1), RAF1(2), RAPGEF2(1), RASA1(2), RASA2(1), RASGRF1(3), RASGRP1(1), RASGRP3(1), RPS6KA1(1), RPS6KA3(2), RPS6KA4(1), SOS1(3), SOS2(1), TAOK3(1), TGFBR1(1), TGFBR2(1), TNF(1), TP53(4)	70433364	161	95	159	49	16	15	24	67	37	2	0.653	1.000	1.000
516	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY2(2), ADCY3(3), ADCY8(3), ADCY9(2), ADORA2A(2), ATP2A1(1), ATP2A2(1), ATP2B1(2), BST1(2), CACNA1A(5), CACNA1C(5), CACNA1D(2), CACNA1G(2), CACNA1H(2), CACNA1I(3), CACNA1S(5), CAMK2A(1), CCKAR(1), CCKBR(2), CHRM1(2), CHRM2(2), CHRM3(1), ERBB2(3), ERBB3(1), ERBB4(3), F2R(1), GNA11(1), GNAS(1), GRIN2A(2), GRIN2D(1), GRM5(1), GRPR(1), HTR2B(1), HTR6(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(3), ITPR3(1), NOS1(1), NOS3(1), NTSR1(1), P2RX1(1), P2RX2(1), P2RX5(1), P2RX7(1), PDE1C(1), PDGFRA(1), PDGFRB(2), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), PLCD1(2), PLCE1(1), PLCG1(1), PLCG2(2), PLCZ1(1), PPP3CA(1), PRKACA(1), PRKCG(3), PRKX(1), PTGFR(2), RYR1(7), RYR2(6), RYR3(5), SLC25A5(1), SLC8A1(2), SLC8A2(1), SLC8A3(1), SPHK1(1), TACR2(1), VDAC2(1), VDAC3(1)	66256450	143	94	142	45	21	23	19	51	29	0	0.381	1.000	1.000
517	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), ANXA6(1), ARRB1(2), ATP2A2(1), ATP2B1(2), CACNA1A(5), CACNA1C(5), CACNA1D(2), CACNA1S(5), CACNB1(2), CALR(1), CAMK1(2), CAMK2A(1), CHRM1(2), CHRM2(2), CHRM3(1), GJB5(1), GNA11(1), GNAI2(1), GNAI3(1), GNAZ(1), GNB1(1), GNG12(1), GRK4(1), GRK5(1), ITPR1(2), ITPR2(3), ITPR3(1), KCNJ3(1), MIB1(1), NME7(1), PLCB3(1), PRKACA(1), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(3), PRKCQ(1), PRKD1(1), RGS1(1), RGS14(1), RGS16(1), RGS20(1), RGS3(1), RGS6(1), RGS7(1), RGS9(1), RYR1(7), RYR2(6), RYR3(5), SFN(1), SLC8A1(2), SLC8A3(1), USP5(2)	45863099	110	81	110	37	16	15	13	39	27	0	0.567	1.000	1.000
518	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(1), CHAD(1), COL11A1(1), COL11A2(1), COL17A1(2), COL1A1(3), COL1A2(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(1), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(4), DES(1), DSC2(2), DSC3(2), DSG3(1), DSG4(2), FN1(4), GJA3(1), GJB5(1), GJC1(1), ITGA6(2), ITGB4(4), KRT1(1), KRT10(1), KRT13(3), KRT17(1), KRT18(1), KRT2(1), KRT23(1), KRT27(2), KRT32(1), KRT33A(1), KRT35(2), KRT37(1), KRT38(1), KRT4(2), KRT40(1), KRT6A(1), KRT6B(1), KRT75(1), KRT76(1), KRT77(2), KRT83(1), KRT84(1), KRT85(2), KRT86(1), KRT9(2), LAMA2(2), LAMA3(2), LAMA4(2), LAMA5(3), LAMB1(7), LAMB2(3), LAMB3(3), LAMB4(1), LAMC3(1), PRPH(2), RELN(2), THBS1(4), THBS2(2), THBS3(1), TNC(3), TNR(1), TNXB(5), VIM(1), VWF(2)	60659946	135	81	135	44	9	14	17	65	29	1	0.740	1.000	1.000
519	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(1), CHAD(1), COL11A1(1), COL11A2(1), COL1A1(3), COL1A2(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(3), COL5A1(2), COL5A2(1), COL6A1(2), COL6A2(1), COL6A3(7), COL6A6(4), DAG1(3), FN1(4), FNDC1(1), GP9(1), HSPG2(1), ITGA1(3), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGA7(1), ITGA8(2), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(4), ITGB7(1), LAMA2(2), LAMA3(2), LAMA4(2), LAMA5(3), LAMB1(7), LAMB2(3), LAMB3(3), LAMB4(1), LAMC3(1), RELN(2), SDC2(1), SDC4(1), SV2B(2), SV2C(1), THBS1(4), THBS2(2), THBS3(1), TNC(3), TNR(1), TNXB(5), VWF(2)	54936826	119	81	119	35	6	12	18	52	30	1	0.546	1.000	1.000
520	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(3), ACACB(1), AKT1(1), AKT2(2), AKT3(2), ARAF(1), BAD(1), BRAF(2), CBL(1), CBLB(1), CBLC(1), CRKL(1), EIF4EBP1(1), EXOC7(2), FASN(5), FOXO1(2), GCK(2), GYS2(2), IKBKB(1), INS(1), IRS1(1), IRS2(2), KRAS(2), LIPE(1), MAP2K2(1), MAPK10(1), NRAS(1), PCK1(1), PCK2(1), PDE3B(2), PFKL(1), PFKP(1), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PPARGC1A(1), PPP1CA(1), PPP1CC(1), PPP1R3A(1), PRKACA(1), PRKAG2(2), PRKAR2A(1), PRKAR2B(1), PRKCI(3), PRKX(1), PTPN1(1), PTPRF(3), PYGB(1), PYGL(1), PYGM(1), RAF1(2), RAPGEF1(1), RHEB(1), SH2B2(1), SHC2(3), SHC4(1), SLC2A4(1), SORBS1(2), SOS1(3), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(4)	39240503	111	80	110	29	8	26	15	41	21	0	0.0941	1.000	1.000
521	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(3), ABLIM1(1), ABLIM2(1), ARHGEF12(3), CFL2(1), DCC(2), DPYSL2(1), EFNA1(2), EFNB2(1), EPHA2(1), EPHA3(1), EPHA4(1), EPHA6(2), EPHA7(1), EPHA8(2), EPHB1(2), EPHB4(2), EPHB6(2), FES(1), GNAI2(1), GNAI3(1), ITGB1(2), KRAS(2), LIMK1(2), LIMK2(2), LRRC4C(2), NCK2(1), NFAT5(1), NFATC2(3), NFATC3(2), NRAS(1), NTNG1(2), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PLXNA1(1), PLXNA2(7), PLXNA3(2), PLXNB1(4), PLXNB2(3), PLXNB3(2), PPP3CA(1), PTK2(1), RAC2(1), RASA1(2), RGS3(1), ROBO1(3), ROBO2(2), ROBO3(1), ROCK2(1), SEMA3A(2), SEMA3D(1), SEMA3E(1), SEMA3F(1), SEMA4D(1), SEMA4F(1), SEMA4G(2), SEMA5A(2), SEMA5B(1), SEMA6B(1), SEMA7A(1), SLIT3(2), SRGAP1(5), SRGAP3(1), UNC5A(2), UNC5B(1), UNC5C(1)	47356802	115	79	114	28	13	13	11	54	24	0	0.229	1.000	1.000
522	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADORA2A(2), ADORA3(1), AGTR2(1), AVPR2(1), C3AR1(2), C5AR1(1), CALCR(1), CALCRL(1), CCKAR(1), CCKBR(2), CHRM1(2), CHRM2(2), CHRM3(1), DRD4(2), DRD5(2), F2(1), F2R(1), F2RL2(1), GABBR1(1), GABRB2(1), GABRB3(1), GABRD(1), GABRG1(1), GABRG2(1), GABRG3(3), GABRQ(1), GIPR(1), GLRA2(1), GPR50(1), GPR83(1), GRIA1(2), GRID1(1), GRID2(3), GRIK1(1), GRIK3(2), GRIK5(1), GRIN2A(2), GRIN2B(1), GRIN2D(1), GRIN3A(1), GRIN3B(2), GRM2(3), GRM4(3), GRM5(1), GRPR(1), HCRTR2(4), HRH3(1), HTR1B(1), HTR2B(1), HTR6(1), LEPR(1), MCHR1(1), NMUR2(2), NPBWR1(1), NPFFR2(1), NPY2R(1), NR3C1(2), NTSR1(1), P2RX1(1), P2RX2(1), P2RX5(1), P2RX7(1), P2RY1(2), P2RY2(1), P2RY6(2), PARD3(1), PRLR(1), PRSS3(1), PTGDR(1), PTGFR(2), PTGIR(1), RXFP2(2), SSTR1(2), SSTR3(1), SSTR4(2), TACR2(1), TRPV1(1), UTS2R(2), VIPR2(1)	53710533	110	77	109	37	18	16	25	42	9	0	0.409	1.000	1.000
523	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM1(1), CADM3(2), CD40(1), CD58(1), CD6(1), CD86(2), CDH1(1), CDH15(1), CDH4(1), CDH5(1), CLDN11(1), CLDN16(1), CLDN18(1), CNTN1(3), CNTNAP1(2), CTLA4(2), ESAM(2), GLG1(1), HLA-A(1), HLA-B(2), HLA-C(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(1), ICAM1(1), ICOS(1), ITGA4(1), ITGA6(2), ITGA8(2), ITGAL(2), ITGAM(3), ITGB1(2), ITGB2(1), ITGB7(1), MADCAM1(1), MPZL1(1), NCAM1(2), NCAM2(4), NEO1(3), NFASC(3), NRCAM(2), NRXN1(2), NRXN2(2), NRXN3(1), PDCD1(1), PTPRC(2), PTPRF(3), PTPRM(5), PVRL1(1), PVRL2(1), PVRL3(2), SDC2(1), SDC4(1), SELE(1), SELL(1), VCAM1(2), VCAN(9)	35864466	99	76	99	35	10	6	13	46	24	0	0.774	1.000	1.000
524	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTG1(1), AKT1(1), AKT2(2), AKT3(2), AMOTL1(3), ASH1L(3), CASK(1), CGN(2), CLDN11(1), CLDN16(1), CLDN18(1), CSNK2A1(2), CTNNA1(3), CTNNA2(1), CTNNA3(1), EPB41L1(3), EPB41L3(3), EXOC4(1), GNAI2(1), GNAI3(1), INADL(5), KRAS(2), MAGI1(1), MAGI2(2), MLLT4(3), MYH10(1), MYH11(2), MYH13(2), MYH14(1), MYH15(2), MYH3(1), MYH4(4), MYH6(2), MYH7(4), MYH7B(1), MYH8(1), MYH9(2), NRAS(1), PARD3(1), PARD6B(4), PPP2CB(1), PPP2R1A(1), PPP2R2A(2), PPP2R2C(2), PRKCD(2), PRKCE(2), PRKCG(3), PRKCI(3), PRKCQ(1), PTEN(5), RAB13(1), RAB3B(1), SPTAN1(4), SRC(1), TJAP1(3), TJP1(3), TJP2(1), YES1(1)	46881368	113	74	111	38	7	11	22	37	36	0	0.872	1.000	1.000
525	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), ARRB1(2), ATF3(1), ATP2A2(1), CAMK2A(1), DGKZ(2), GABPA(1), GBA2(1), GNB1(1), GNG12(1), GRK4(1), GRK5(1), IGFBP1(1), IGFBP4(1), IGFBP6(2), ITPR1(2), ITPR2(3), ITPR3(1), MIB1(1), NFKB1(1), NOS1(1), NOS3(1), PLCB3(1), PLCD1(2), PLCG1(1), PLCG2(2), PRKACA(1), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCQ(1), PRKD1(1), RGS1(1), RGS14(1), RGS16(1), RGS20(1), RGS3(1), RGS6(1), RGS7(1), RGS9(1), RYR1(7), RYR2(6), RYR3(5), SFN(1), SLC8A1(2), TNXB(5), USP5(2)	42394971	92	73	92	27	12	14	10	33	23	0	0.347	1.000	1.000
526	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), ADK(1), ADSL(2), ADSSL1(1), AK7(2), AMPD2(2), DCK(1), ENPP1(4), ENPP3(1), ENTPD1(1), ENTPD5(1), ENTPD6(2), GART(2), GMPS(1), GUCY1B3(2), GUCY2C(2), GUCY2D(2), NME7(1), NPR2(1), NT5C1B(1), NUDT5(1), PAPSS2(2), PDE11A(2), PDE1C(1), PDE2A(2), PDE3B(2), PDE5A(4), PDE7B(1), PDE9A(2), PFAS(1), PNPT1(2), POLA1(3), POLD1(1), POLR1A(1), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLR3A(1), POLR3B(2), PPAT(1), PRIM1(1), PRIM2(2), PRPS2(1), PRUNE(1), RFC5(2)	39777822	91	71	91	25	8	13	9	41	20	0	0.436	1.000	1.000
527	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(2), BCAR1(1), CAPN1(1), CAPN11(1), CAPN2(2), CAPN3(1), CAPN5(2), CAPN7(3), CAPN9(1), CAV2(1), DOCK1(2), GIT2(1), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGA7(1), ITGA8(2), ITGAD(2), ITGAE(1), ITGAL(2), ITGAM(3), ITGAX(4), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(4), ITGB5(4), ITGB7(1), MAP2K2(1), MAP2K3(1), MAPK10(1), MAPK6(1), MAPK7(3), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PIK3R2(1), PTK2(1), PXN(1), RAC2(1), RAPGEF1(1), ROCK2(1), SEPP1(1), SORBS1(2), SOS1(3), SRC(1), TLN1(7), TNS1(2)	32890666	89	70	88	23	5	14	12	38	20	0	0.268	1.000	1.000
528	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(2), ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADK(1), ADSL(2), AMPD2(2), ATP5A1(1), ATP5B(1), ATP5F1(1), DCK(1), ENPP1(4), ENPP3(1), ENTPD1(1), GART(2), GMPS(1), GUCY1B3(2), GUCY2C(2), GUCY2D(2), NPR2(1), PAPSS2(2), PDE5A(4), PDE6B(2), PDE6C(1), PDE7B(1), PDE9A(2), PFAS(1), POLB(1), POLD1(1), POLG(2), POLQ(5), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLRMT(2), PPAT(1), PRPS2(1), PRUNE(1)	31069063	75	60	75	19	7	12	11	27	18	0	0.298	1.000	1.000
529	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACTG1(1), BAIAP2(1), CDH1(1), CREBBP(4), CSNK2A1(2), CTNNA1(3), CTNNA2(1), CTNNA3(1), EP300(5), ERBB2(3), FARP2(1), FGFR1(1), IGF1R(1), IQGAP1(1), LEF1(1), LMO7(1), MAP3K7(1), MLLT4(3), NLK(1), PARD3(1), PTPN1(1), PTPRB(2), PTPRF(3), PTPRJ(5), PTPRM(5), PVRL1(1), PVRL2(1), PVRL3(2), RAC2(1), SMAD4(2), SNAI2(1), SORBS1(2), SRC(1), SSX2IP(2), TCF7L1(1), TGFBR1(1), TGFBR2(1), TJP1(3), WASF1(1), YES1(1)	28220964	71	56	71	25	4	11	8	25	22	1	0.837	1.000	1.000
530	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), EGF(1), GNA11(1), GNAI2(1), GNAI3(1), GNAS(1), GRM5(1), GUCY1B3(2), GUCY2C(2), GUCY2D(2), HTR2B(1), ITPR1(2), ITPR2(3), ITPR3(1), KRAS(2), MAP2K2(1), MAP2K5(2), MAPK7(3), NPR2(1), NRAS(1), PDGFD(1), PDGFRA(1), PDGFRB(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), PRKACA(1), PRKCG(3), PRKG1(1), PRKG2(1), PRKX(1), RAF1(2), SOS1(3), SOS2(1), SRC(1), TJP1(3), TUBA4A(1), TUBB(1), TUBB1(1)	32161619	71	55	69	29	8	14	3	31	15	0	0.850	1.000	1.000
531	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), CACNA1C(5), CACNA1D(2), CACNA1S(5), CAMK2A(1), GNA11(1), GNAS(1), ITPR1(2), ITPR2(3), ITPR3(1), KRAS(2), MAP2K2(1), MAP2K3(1), MAP3K1(2), MAP3K4(1), MAPK10(1), MAPK7(3), NRAS(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), PRKACA(1), PRKCD(2), PRKX(1), RAF1(2), SOS1(3), SOS2(1), SRC(1)	31229289	65	53	63	31	7	16	4	21	17	0	0.946	1.000	1.000
532	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(3), ACTR2(1), AKT1(1), AKT2(2), AKT3(2), ARHGEF6(2), ARHGEF7(1), BCAR1(1), BRAF(2), CDKN2A(1), CSE1L(2), DOCK1(2), GRB7(1), ITGA1(3), ITGA10(1), ITGA11(1), ITGA2(1), ITGA3(1), ITGA4(1), ITGA6(2), ITGA7(1), ITGA8(2), ITGB3BP(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), P4HB(1), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PIK3CA(2), PIK3CB(1), PLCG1(1), PLCG2(2), PTEN(5), PTK2(1), RAF1(2), ROCK2(1), SOS1(3), SOS2(1), SRC(1), TLN1(7), TLN2(3)	29834825	74	53	74	21	3	10	12	31	18	0	0.488	1.000	1.000
533	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA2A(2), ADORA3(1), AGTR2(1), AVPR2(1), C3AR1(2), CCKAR(1), CCKBR(2), CCR2(1), CCR3(2), CCR5(1), CCR7(1), CCRL2(1), CHRM1(2), CHRM2(2), CHRM3(1), DRD4(2), DRD5(2), F2R(1), F2RL2(1), GPR174(2), GPR3(1), GPR37(2), GPR37L1(1), GPR50(1), GPR83(1), GPR85(1), GPR87(1), GRPR(1), HCRTR2(4), HRH3(1), HTR1B(1), HTR2B(1), HTR6(1), NMUR2(2), NPY2R(1), NTSR1(1), OR11A1(1), OR1F1(1), OR5V1(1), P2RY1(2), P2RY2(1), P2RY6(2), PTGDR(1), PTGFR(2), PTGIR(1), SSTR1(2), SSTR3(1), SSTR4(2), SUCNR1(1)	29328947	68	52	68	21	8	7	10	33	10	0	0.459	1.000	1.000
534	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(2), ABCA10(1), ABCA12(5), ABCA13(5), ABCA3(1), ABCA4(4), ABCA5(3), ABCA6(2), ABCA7(4), ABCA8(2), ABCB10(1), ABCB11(1), ABCB4(3), ABCB5(1), ABCB6(2), ABCB9(2), ABCC1(2), ABCC10(2), ABCC11(2), ABCC12(1), ABCC2(3), ABCC4(2), ABCC5(3), ABCC9(1), ABCD2(1), ABCD4(1), ABCG2(2), ABCG4(2), ABCG5(1), ABCG8(1), CFTR(3), TAP1(1)	28819866	67	52	67	23	6	9	11	32	9	0	0.640	1.000	1.000
535	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(3), ANAPC10(1), ANAPC4(1), ANAPC5(2), ATM(1), ATR(3), BUB1(1), CCNB1(1), CCNB2(1), CCNE1(1), CCNE2(1), CDC14B(1), CDC16(1), CDC20(2), CDC6(1), CDC7(1), CDKN2A(1), CHEK1(1), CREBBP(4), CUL1(2), E2F2(1), E2F3(1), EP300(5), ESPL1(3), GADD45B(1), MAD1L1(1), MCM2(2), MCM3(1), MCM5(1), MCM6(1), MCM7(1), PKMYT1(1), PLK1(1), PRKDC(2), RBL2(2), SFN(1), SMAD4(2), SMC1A(2), SMC1B(2), TP53(4)	32631388	65	52	65	23	5	8	11	26	15	0	0.794	1.000	1.000
536	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ARHGAP5(2), BCAR1(1), CDH5(1), CLDN11(1), CLDN16(1), CLDN18(1), CTNNA1(3), CTNNA2(1), CTNNA3(1), ESAM(2), EZR(1), GNAI2(1), GNAI3(1), ICAM1(1), ITGA4(1), ITGAL(2), ITGAM(3), ITGB1(2), ITGB2(1), MLLT4(3), MSN(1), NOX1(1), NOX3(1), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PLCG1(1), PLCG2(2), PRKCG(3), PTK2(1), PTPN11(1), PXN(1), RAC2(1), RAPGEF3(1), RAPGEF4(1), ROCK2(1), SIPA1(1), TXK(1), VAV1(1), VCAM1(2)	30333740	60	49	60	17	5	9	8	30	8	0	0.569	1.000	1.000
537	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), ASIP(1), CAMK2A(1), CREB3L3(1), CREBBP(4), EP300(5), FZD1(2), FZD10(1), FZD4(1), FZD5(1), FZD7(1), GNAI2(1), GNAI3(1), GNAS(1), KRAS(2), LEF1(1), MAP2K2(1), MITF(3), NRAS(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), POMC(1), PRKACA(1), PRKCG(3), PRKX(1), RAF1(2), TCF7L1(1), TYRP1(2), WNT10A(2), WNT10B(1), WNT3(1), WNT8A(1), WNT8B(1)	26554216	64	49	63	23	6	12	5	23	18	0	0.737	1.000	1.000
538	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY8(3), ARAF(1), BRAF(2), CACNA1C(5), CAMK2A(1), CREBBP(4), EP300(5), GRIA1(2), GRIN2A(2), GRIN2B(1), GRIN2D(1), GRM5(1), ITPR1(2), ITPR2(3), ITPR3(1), KRAS(2), MAP2K2(1), NRAS(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(1), PPP1CA(1), PPP1CC(1), PPP1R12A(1), PPP3CA(1), PRKACA(1), PRKCG(3), PRKX(1), RAF1(2), RAPGEF3(1), RPS6KA1(1), RPS6KA3(2)	24414221	58	46	57	23	3	13	7	22	13	0	0.800	1.000	1.000
539	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY2(2), ADCY3(3), ADCY5(2), ADCY6(1), ADCY8(3), ADCY9(2), AKAP1(1), AKAP10(1), AKAP11(1), AKAP12(2), AKAP3(2), AKAP5(1), AKAP6(1), AKAP9(2), GNA11(1), GNAI2(1), GNAI3(1), GNAZ(1), GNB1(1), GNG10(1), GNG12(1), ITPR1(2), KCNJ3(1), KRAS(2), NRAS(1), PALM2(1), PDE1C(1), PDE7B(1), PLCB3(1), PPP3CA(1), PRKACA(1), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(3), PRKCI(3), PRKCQ(1), PRKD1(1), USP5(2)	28359282	59	44	58	21	3	13	5	20	18	0	0.708	1.000	1.000
540	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), DES(1), DMD(3), MYBPC1(2), MYH3(1), MYH6(2), MYH7(4), MYH8(1), MYL1(1), MYOM1(1), NEB(9), TCAP(1), TMOD1(1), TPM4(1), TTN(23), VIM(1)	33187110	53	44	52	16	4	9	6	22	12	0	0.568	1.000	1.000
541	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(1), AKT2(2), AKT3(2), BAD(1), CDKN2A(1), ERBB4(3), F2RL2(1), GAB1(1), GSK3A(1), IGFBP1(1), INPPL1(2), IRS1(1), IRS2(2), NOLC1(2), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PARD3(1), PIK3CA(2), PIK3CD(1), PREX1(1), PTEN(5), PTK2(1), PTPN1(1), RPS6KA1(1), RPS6KA3(2), SFN(1), SLC2A4(1), SOS1(3), SOS2(1), TSC1(2), TSC2(4)	18022048	53	42	53	17	6	10	13	10	14	0	0.330	1.000	1.000
542	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(3), ATM(1), BUB1(1), CCNB1(1), CCNB2(1), CCNE1(1), CCNE2(1), CDAN1(2), CDC14B(1), CDC20(2), CDC6(1), CDC7(1), CDH1(1), CDKN2A(1), CHEK1(1), DTX4(1), E2F2(1), E2F3(1), EP300(5), ESPL1(3), HDAC5(3), HDAC6(1), HDAC8(1), MAD1L1(1), MCM2(2), MCM3(1), MCM5(1), MCM6(1), MCM7(1), MPEG1(1), PLK1(1), PRKDC(2), PTPRA(1), SMAD4(2), TP53(4)	26807069	53	41	53	17	5	7	7	22	12	0	0.646	1.000	1.000
543	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(1), AKT1(1), AKT2(2), AKT3(2), APAF1(1), ATM(1), BAD(1), BID(1), BIRC3(1), CAPN1(1), CAPN2(2), CASP10(1), CASP9(1), CSF2RB(1), FASLG(2), IKBKB(1), IL1R1(1), NFKB1(1), NFKB2(2), NFKBIA(2), NTRK1(2), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), PPP3CA(1), PRKACA(1), PRKAR2A(1), PRKAR2B(1), RELA(1), TNF(1), TNFSF10(3), TP53(4)	20378790	50	41	50	17	3	5	8	22	12	0	0.754	1.000	1.000
544	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(3), DCK(1), DPYD(1), DPYS(2), ENTPD1(1), ENTPD5(1), ENTPD6(2), NME7(1), NT5C1B(1), PNPT1(2), POLA1(3), POLD1(1), POLR1A(1), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLR3A(1), POLR3B(2), PRIM1(1), PRIM2(2), RFC5(2), TK2(1), TXNRD1(2), TYMS(1), UPRT(1)	19758467	43	39	43	14	4	4	5	18	12	0	0.814	1.000	1.000
545	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	BAD(1), CABIN1(3), CREBBP(4), CSNK2A1(2), CTLA4(2), EP300(5), GSK3A(1), ICOS(1), JUNB(1), NCK2(1), NFAT5(1), NFATC2(3), NFATC3(2), NFKB2(2), NUP214(4), P2RX7(1), PAK1(1), PPIA(1), PTPRC(2), RELA(1), SFN(1), TNF(1), TRPV6(1), VAV1(1)	21928364	43	36	43	14	4	3	8	14	14	0	0.784	1.000	1.000
546	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), AKT2(2), AKT3(2), CD40(1), CD86(2), IFNA16(1), IFNA2(1), IFNAR1(1), IKBKB(1), IKBKE(1), IRF5(1), MAP2K2(1), MAP2K3(1), MAP3K7(1), MAP3K8(1), MAPK10(1), NFKB1(1), NFKB2(2), NFKBIA(2), PIK3CA(2), PIK3CB(1), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R5(1), RELA(1), STAT1(1), TLR1(1), TLR3(1), TLR4(1), TLR5(2), TLR6(1), TLR7(1), TNF(1)	21710298	43	36	43	13	3	5	6	19	9	1	0.636	1.000	1.000
547	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(1), ACSL1(2), ACSL6(1), AKT1(1), AKT2(2), AKT3(2), CAMKK1(2), CD36(1), IKBKB(1), IRS1(1), IRS2(2), JAK1(2), JAK2(1), JAK3(1), LEPR(1), MAPK10(1), NFKB1(1), NFKB2(2), NFKBIA(2), PCK1(1), PCK2(1), POMC(1), PPARGC1A(1), PRKAG2(2), PRKCQ(1), PTPN11(1), RELA(1), SLC2A1(1), SLC2A4(1), STK11(2), TNF(1), TNFRSF1B(1)	20225618	42	36	42	13	6	6	6	15	9	0	0.474	1.000	1.000
548	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(1), AKT2(2), AKT3(2), CBL(1), CDKN2A(1), F2RL2(1), GSK3A(1), IGFBP1(1), INPPL1(2), IRS1(1), IRS2(2), LNPEP(1), PARD3(1), PIK3CA(2), PIK3CD(1), PIK3R1(2), PTEN(5), PTPN1(1), RAF1(2), RPS6KA1(1), RPS6KA3(2), SFN(1), SLC2A4(1), SORBS1(2), SOS1(3), SOS2(1)	14376745	41	35	41	18	3	7	8	11	12	0	0.899	1.000	1.000
549	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(1), BAD(1), BAK1(1), BCL2L11(1), BID(1), BIRC3(1), BIRC5(1), CASP1(1), CASP10(1), CASP4(1), CASP9(1), FASLG(2), HELLS(2), IKBKB(1), IRF2(1), IRF5(1), IRF6(1), MAP3K1(2), MAPK10(1), NFKB1(1), NFKBIA(2), PLEKHG5(1), RELA(1), TNF(1), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFSF10(3), TP53(4)	13965315	40	34	40	13	4	7	7	14	8	0	0.655	1.000	1.000
550	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(2), CREBBP(4), CTBP1(1), DTX1(1), DTX3L(1), DTX4(1), EP300(5), JAG1(3), JAG2(1), MAML1(4), MAML2(4), MAML3(3), NCSTN(1), NOTCH1(5), NOTCH2(3), NOTCH3(2), NUMB(1), PTCRA(1), RBPJL(1)	17116558	44	34	43	36	1	10	4	15	13	1	1.000	1.000	1.000
551	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM17(2), ATP6AP1(1), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), CXCL1(1), GIT1(1), IKBKB(1), LYN(1), MAPK10(1), NFKB1(1), NFKB2(2), NFKBIA(2), NOD1(2), PAK1(1), PLCG1(1), PLCG2(2), PTPN11(1), PTPRZ1(4), RELA(1), SRC(1), TCIRG1(2), TJP1(3)	16387167	35	34	35	17	3	3	2	22	5	0	0.974	1.000	1.000
552	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(4), CDR1(2), IL6ST(3), RPL10(1), RPL11(1), RPL13(1), RPL14(1), RPL18(1), RPL19(1), RPL22(1), RPL24(1), RPL26(1), RPL3(2), RPL3L(1), RPL6(1), RPL7A(3), RPS14(1), RPS2(1), RPS24(1), RPS6KA1(1), RPS6KA3(2), RPS7(1), RPS8(1), RPSA(1), SLC36A2(1), UBA52(1)	12656260	36	34	34	10	2	4	7	13	10	0	0.547	1.000	1.000
553	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(2), CEBPA(1), DAXX(1), IKBKB(1), MAP2K2(1), MAP2K3(1), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K4(1), MAP3K6(1), MAP3K7(1), MAP3K8(1), MAP3K9(1), MAP4K1(2), MAP4K3(2), MAPK10(1), MAPK6(1), MAPK7(3), NFKB1(1), NFKBIA(2), PAK1(1), RAF1(2), RELA(1), RPS6KA1(1), RPS6KA3(2), RPS6KA4(1), STAT1(1), TGFBR1(1)	23459528	39	33	38	21	2	4	5	17	10	1	0.995	1.000	1.000
554	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(1), ALG6(1), CCKBR(2), CCR2(1), CCR3(2), CCR5(1), CELSR1(4), CELSR2(2), CELSR3(2), CHRM2(2), CHRM3(1), CIDEB(1), DRD4(2), EMR2(1), F2R(1), GPR116(1), GPR133(3), GPR135(2), GPR18(2), GPR55(1), GRPR(1), LPHN2(1), NTSR1(1), PTGFR(2)	16132772	38	32	37	16	5	5	5	18	5	0	0.851	1.000	1.000
555	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY6(1), ADCY8(3), CACNA1A(5), GNAS(1), GNB1(1), GRM4(3), ITPR3(1), PLCB2(2), PRKACA(1), PRKX(1), SCNN1A(1), SCNN1B(2), TAS1R1(1), TAS1R2(4), TAS2R13(1), TAS2R14(1), TAS2R39(1), TAS2R41(1), TAS2R43(1), TRPM5(1)	13938682	33	32	33	14	12	5	2	7	7	0	0.683	1.000	1.000
556	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), AKT1(1), AKT2(2), AKT3(2), CFL2(1), INPPL1(2), ITPR1(2), ITPR2(3), ITPR3(1), LIMK1(2), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), PIK3CA(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PTEN(5), ROCK2(1), WASF1(1)	17044755	35	31	35	11	4	8	4	11	8	0	0.613	1.000	1.000
557	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(1), CD36(1), CITED2(1), CREBBP(4), EHHADH(1), EP300(5), HSD17B4(1), INS(1), LPL(1), MRPL11(1), NCOA1(1), NCOR1(3), NFKBIA(2), NR2F1(1), PIK3CA(2), PIK3R1(2), PRKAR2A(1), PRKAR2B(1), PTGS2(1), RELA(1), STAT5A(1), TNF(1)	15348533	34	30	34	23	1	6	2	13	12	0	0.999	1.000	1.000
558	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP7(1), BMP8A(1), CSNK1E(3), FBXW11(1), GLI1(3), GLI3(2), IHH(1), LRP2(6), PRKACA(1), PRKX(1), PTCH1(1), SHH(1), SUFU(2), WNT10A(2), WNT10B(1), WNT3(1), WNT8A(1), WNT8B(1), ZIC2(1)	14688580	31	29	31	12	4	8	4	8	7	0	0.769	1.000	1.000
559	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AGT(3), AKT1(1), CALR(1), CAMK1(2), CREBBP(4), F2(1), HAND2(1), NFATC2(3), NFATC3(2), NKX2-5(3), PIK3CA(2), PIK3R1(2), PPP3CA(1), PRKAR2A(1), PRKAR2B(1), RAF1(2)	12246765	31	28	31	16	3	6	2	12	8	0	0.977	1.000	1.000
560	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(2), ERBB2(3), ERBB4(3), ETS1(1), FMN2(1), KRAS(2), NOTCH1(5), NOTCH2(3), NOTCH3(2), PIWIL4(1), RAF1(2), SOS1(3), SOS2(1), SPIRE2(1)	12751383	30	27	29	13	2	7	3	8	10	0	0.864	1.000	1.000
561	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ASAH1(1), BRAF(2), CAMP(1), CREBBP(4), CRKL(1), DAG1(3), MAP1B(2), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), NTRK1(2), PIK3C2G(2), PIK3CA(2), PIK3CD(1), PIK3R1(2), PTPN11(1), RPS6KA3(2), SRC(1)	12590470	31	27	31	14	2	7	5	9	8	0	0.842	1.000	1.000
562	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(3), ACADL(3), ACOX1(1), ACOX2(1), ACOX3(3), ACSL1(2), ACSL6(1), AQP7(1), CD36(1), CYP4A11(1), CYP4A22(1), EHHADH(1), LPL(1), PCK1(1), PCK2(1), SCP2(1), SLC27A1(2), SLC27A6(1), SORBS1(2)	15827210	28	26	28	13	2	5	1	11	8	1	0.940	1.000	1.000
563	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	BAK1(1), BFAR(1), CAD(3), CASP10(1), DAXX(1), DEDD(1), DIABLO(1), MAP3K1(2), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), NFAT5(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), RALBP1(1), SMPD1(3), TP53(4), TPX2(1)	17163565	30	26	30	16	6	5	1	12	6	0	0.966	1.000	1.000
564	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), DLD(2), GAB1(1), GCK(2), IL1R1(1), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K4(1), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK7(3), MYEF2(1), NFATC3(2), PAPPA(3), TP53(4)	12192773	29	26	28	13	0	4	3	16	4	2	0.928	1.000	1.000
565	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(1), BID(1), BIRC3(1), CASP9(1), DAXX(1), GSN(2), MAP3K1(2), NFKB1(1), NFKBIA(2), NUMA1(3), PRKCD(2), PRKDC(2), PTK2(1), RASA1(2), RELA(1), SPTAN1(4), TNF(1), TNFRSF1B(1)	16904972	30	24	30	14	1	5	3	7	14	0	0.976	1.000	1.000
566	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(1), CDS2(1), CHPT1(1), DGKA(1), DGKB(1), DGKD(2), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(2), ETNK2(1), GPAM(2), GPD1(1), GPD1L(1), LCAT(2), PLA2G2D(1), PLA2G4A(1), PLA2G6(1), PNPLA3(1)	16043359	26	24	26	12	1	4	2	12	7	0	0.890	1.000	1.000
567	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(1), BAK1(1), BID(1), BIRC3(1), CASP9(1), FASLG(2), MAP3K1(2), MAPK10(1), NFKB1(1), NFKBIA(2), PARP1(2), RELA(1), TNF(1), TNFRSF1B(1), TNFSF10(3), TP53(4)	9071357	25	23	25	11	2	4	4	9	6	0	0.907	1.000	1.000
568	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(2), CREBBP(4), EP300(5), ERCC3(3), GRIP1(2), GTF2A1(1), HDAC5(3), HDAC6(1), POLR2A(3)	11349198	24	23	24	20	3	3	2	9	7	0	1.000	1.000	1.000
569	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	MAP3K1(2), NFATC2(3), NFATC3(2), NFKB1(1), NFKBIA(2), PIK3CA(2), PIK3R1(2), PLCG1(1), PPP3CA(1), RAF1(2), RASA1(2), RELA(1), SOS1(3), VAV1(1), ZAP70(1)	11556184	26	23	26	10	2	4	0	10	10	0	0.934	1.000	1.000
570	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(3), EEF1B2(1), EEF1D(1), EEF1G(1), EEF2(2), EEF2K(3), EIF1AX(1), EIF2AK1(3), EIF2S3(1), EIF4A1(1), EIF4A2(1), EIF4EBP1(1), EIF4G1(1), EIF4G3(4), EIF5B(1), GSPT2(1), PABPC1(1), PABPC3(1)	10676948	28	23	28	11	1	6	2	12	6	1	0.844	1.000	1.000
571	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(2), COX10(3), COX15(1), CP(3), EPRS(2), FTMT(1), HMOX1(1), UGT1A1(1), UGT1A3(1), UGT1A5(1), UGT1A9(1), UGT2A3(1), UGT2B17(1), UGT2B28(1), UGT2B7(1), UROD(1)	10162867	22	22	22	12	2	1	4	12	3	0	0.974	1.000	1.000
572	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(1), CANX(1), CIITA(2), CTSB(1), HLA-A(1), HLA-B(2), HLA-C(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(1), HSP90AA1(1), IFNA16(1), IFNA2(1), KIR3DL2(1), KIR3DL3(1), KLRC1(1), KLRC3(1), NFYA(1), PSME2(2), RFX5(1), TAP1(1)	11230460	25	22	25	13	2	3	2	8	8	2	0.948	1.000	1.000
573	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CEBPA(1), DAXX(1), EGF(1), ETS1(1), HOXA7(1), IKBKB(1), MAP2K3(1), MAP3K1(2), NFKB1(1), NFKBIA(2), PRKCD(2), PRKCE(2), PRKCG(3), PRKCQ(1), RAF1(2), RELA(1), TNF(1), TNFRSF1B(1)	11852566	25	22	25	11	2	3	0	11	9	0	0.978	1.000	1.000
574	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(1), CHRM1(2), CHRNA1(1), FLT1(1), FLT4(3), KDR(1), NOS3(1), PDE2A(2), PDE3B(2), PRKAR2A(1), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(6), SLC7A1(1)	9974508	26	22	26	11	2	5	2	14	3	0	0.785	1.000	1.000
575	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(2), AKT3(2), DLG4(1), LPA(3), MAP3K1(2), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), PHKA2(2), PI3(1), PIK3CB(1), PTK2(1), RDX(1), ROCK2(1)	11881709	24	22	24	13	5	4	4	8	3	0	0.912	1.000	1.000
576	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(1), DLD(2), GAPDH(2), GAPDHS(2), GCK(2), HK1(1), LDHB(1), MDH1(1), PC(5), PCK1(1), PDHX(1), PFKL(1), PFKP(1), PGAM2(1), PGK2(1), TPI1(1)	10258603	24	21	24	10	0	1	4	7	11	1	0.941	1.000	1.000
577	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	ERCC3(3), GTF2B(2), POLR1A(1), POLR1B(2), POLR2A(3), POLR2B(3), POLR2F(1), POLR2J(1), POLR3B(2), TAF6(1), TAF7(1)	8514400	20	20	20	10	3	1	2	9	5	0	0.945	1.000	1.000
578	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAD(1), CASP1(1), CASP10(1), CASP4(1), CASP9(1), CD40(1), DAXX(1), FASLG(2), IKBKE(1), NFKB1(1), NFKBIA(2), NR3C1(2), NTRK1(2), TNF(1), TNFRSF1B(1)	10586289	20	18	20	11	1	4	4	6	5	0	0.963	1.000	1.000
579	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTR2(1), AKT1(1), CFL2(1), FLNA(1), FLNC(4), FSCN1(1), LIMK1(2), PAK1(1), PAK3(1), PAK4(1), PAK6(1), PAK7(1), ROCK2(1), WASF1(1)	11675079	19	18	19	12	3	5	1	7	3	0	0.966	1.000	1.000
580	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2S3(1), FLT1(1), FLT4(3), HIF1A(1), KDR(1), NOS3(1), PIK3CA(2), PIK3R1(2), PLCG1(1), PTK2(1), PXN(1), VHL(2)	8304437	17	16	17	10	2	3	2	4	5	1	0.982	1.000	1.000
581	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT1(1), GAA(1), GCK(2), HK1(1), LCT(3), MGAM(3), PFKL(1), PFKP(1), PGM1(1), RDH11(1), RDH13(1)	9419138	16	15	16	10	3	1	0	8	4	0	0.991	1.000	1.000
582	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(3), ACTG1(1), CDH1(1), EZR(1), ITGB1(2), KRT18(1), NCK2(1), ROCK2(1), TLR4(1), TLR5(2), TUBA4A(1), TUBB(1), TUBB1(1)	12457157	17	15	17	11	2	1	4	6	4	0	0.974	1.000	1.000
583	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(3), ACTG1(1), CDH1(1), EZR(1), ITGB1(2), KRT18(1), NCK2(1), ROCK2(1), TLR4(1), TLR5(2), TUBA4A(1), TUBB(1), TUBB1(1)	12457157	17	15	17	11	2	1	4	6	4	0	0.974	1.000	1.000
584	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIL1(1), PIK3CA(2), PIK3CD(1), PIK3R1(2), TRAF5(2)	8277851	17	15	17	10	3	3	2	5	4	0	0.968	1.000	1.000
585	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(1), DAXX(1), MAP3K1(2), MAP3K7(1), PAK1(1), PRKDC(2), RIPK2(2), SPTAN1(4)	10034649	14	14	14	11	1	1	1	3	7	1	0.999	1.000	1.000
586	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(1), GTF2B(2), NCOA1(1), NCOA2(2), NCOA3(3), POLR2A(3)	6100881	15	14	15	12	3	1	1	5	5	0	0.990	1.000	1.000
587	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	MADD(3), MAP3K1(2), MAP3K7(1), PAK1(1), PRKDC(2), SPTAN1(4), TNF(1)	9504571	14	14	14	11	0	1	2	4	6	1	0.999	1.000	1.000
588	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	MAP3K1(2), NFATC2(3), NFKB1(1), NFKBIA(2), PLCG1(1), PPP3CA(1), PRKAR2A(1), PRKAR2B(1), RELA(1), VIPR2(1)	6740139	14	14	14	10	2	1	0	5	6	0	0.997	1.000	1.000
589	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	AKT1(1), CAMK2A(1), GNAS(1), PIK3CA(2), PIK3R1(2), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1), SOS1(3)	7088184	13	13	13	10	1	3	1	4	4	0	0.982	1.000	1.000
590	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	AKT1(1), BAD(1), CSF2RB(1), IGF1R(1), PIK3CA(2), PIK3R1(2), PRKAR2A(1), PRKAR2B(1)	5299040	10	10	10	10	0	2	1	5	2	0	0.997	1.000	1.000
591	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	CHRM1(2), CHRM2(2), CHRM3(1), DRD4(2), DRD5(2), HTR1B(1), HTR2B(1), HTR6(1)	6237696	12	10	12	7	2	2	0	8	0	0	0.875	1.000	1.000
592	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN2A(2), GRIN2B(1), GRIN2D(1), NOS1(1), PPP3CA(1), PRKAR2A(1), PRKAR2B(1)	6245446	9	9	9	10	1	1	3	2	2	0	0.997	1.000	1.000
593	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	DAXX(1), MAP3K1(2), MAP3K7(1), MAP3K9(1), PLA2G4A(1), STAT1(1), TGFBR1(1)	8929280	8	8	8	10	0	1	0	4	2	1	1.000	1.000	1.000
594	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	PLCB1(1), PPP1CA(1), PPP3CA(1), PRKAR2A(1), PRKAR2B(1)	3876831	5	5	5	10	0	0	0	2	3	0	1.000	1.000	1.000
595	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GPHN(3), SRC(1)	2886800	6	5	6	5	2	0	0	4	0	0	0.962	1.000	1.000
596	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), SHH(1), XPO1(2)	2100921	4	4	4	3	1	1	2	0	0	0	0.840	1.000	1.000
597	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(1), ARPC2(1), WASF1(1)	1971981	4	4	4	4	0	2	0	2	0	0	0.976	1.000	1.000
598	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK4(1), EIF2S3(1), PPP1CA(1)	2785218	3	3	3	4	1	0	1	1	0	0	0.982	1.000	1.000
599	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	HK1(1), PFKL(1), TPI1(1)	2242801	3	3	3	4	0	1	1	1	0	0	0.951	1.000	1.000
600	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	GNAS(1), GNB1(1), PRKACA(1)	1611682	3	3	3	2	1	0	1	1	0	0	0.908	1.000	1.000
601	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH4(1), ADH6(1)	1351854	2	2	2	2	0	0	0	2	0	0	0.968	1.000	1.000
602	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	PRKCE(2)	1807032	2	2	2	3	0	0	0	2	0	0	0.990	1.000	1.000
603	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(1), RDH13(1)	1161009	2	2	2	2	0	0	0	2	0	0	0.953	1.000	1.000
604	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(1), PLCG1(1)	3321693	2	1	2	4	0	0	0	2	0	0	0.997	1.000	1.000
605	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(1)	2297103	1	1	1	7	0	0	0	1	0	0	1.000	1.000	1.000
606	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8		958254	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
607	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4		574789	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3		635606	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
609	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		174446	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
610	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		367212	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2		483874	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5		1133971	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8		1816887	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		409103	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6		929316	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		277652	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
