rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(5)	206449	5	5	5	0	3	1	1	0	0	0	0.196	0.000785	0.484
2	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(7), JUND(1), PPP1R1B(1)	1097157	9	9	9	1	6	1	2	0	0	0	0.169	0.00442	0.779
3	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IFNG(2), IL12A(5), IL12B(1), IL16(2), IL18(2), IL4(1), IL6(2), LTA(1), TNF(2)	2913639	19	19	19	2	7	1	7	2	2	0	0.0792	0.00532	0.779
4	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	MUSK(4), PIK3CA(7), PIK3R1(2), PTK2(6), PTK2B(4), RAPSN(1), SRC(1), YWHAH(1)	4891704	26	24	25	2	12	3	4	1	6	0	0.0214	0.00592	0.779
5	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	BCAR1(2), ITGB1(1), MAPK1(1), PDK2(1), PIK3CA(7), PIK3R1(2), PTK2(6), SHC1(2), SOS1(4)	5556210	26	25	25	1	15	5	1	2	3	0	0.00281	0.00632	0.779
6	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(1), HTR2C(4), PLCB1(7), TUB(1)	2093699	13	13	13	1	3	3	3	0	4	0	0.150	0.00760	0.780
7	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), NR3C1(2), RXRA(5), TNF(2)	1684442	10	10	10	1	4	1	3	2	0	0	0.249	0.0190	1.000
8	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR0B2(2), NR1H3(2), RXRA(5)	1561481	10	10	10	0	5	3	0	2	0	0	0.0499	0.0224	1.000
9	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(2), JAK1(2), JAK2(4), STAT1(2)	2415080	12	12	12	0	4	0	4	2	2	0	0.0724	0.0264	1.000
10	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IFNG(2), IL12A(5), IL12B(1), IL18(2)	906619	10	10	10	2	3	1	4	0	2	0	0.431	0.0317	1.000
11	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(7), PIK3R1(2), PLCB1(7), PLCG1(3), PRKCA(1), VAV1(3)	3804343	23	20	22	2	10	6	2	0	5	0	0.0384	0.0320	1.000
12	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(2), JUN(1), KEAP1(8), MAPK1(1), MAPK14(2), PRKCA(1)	2327693	15	13	15	0	10	3	1	0	1	0	0.00835	0.0346	1.000
13	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), CFL1(1), GNAS(7), GNB1(1), MAP2K1(1), MAPK1(1), NOX1(3), PIK3C2G(5), PLCB1(7), PPP1R12B(1), PRKCA(1), PTK2(6), RAF1(1), ROCK2(3)	7554889	40	36	38	3	20	9	7	1	3	0	0.00336	0.0445	1.000
14	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), LPO(3), MPO(5), PRDX1(1), PRDX2(1), TPO(9), TYR(4)	2869824	25	23	25	4	10	4	5	0	6	0	0.113	0.0459	1.000
15	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(9), SDS(2)	1439908	12	7	12	1	6	2	2	1	1	0	0.119	0.0570	1.000
16	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), CPS1(6), GLS(1), GLUD1(2)	2268970	11	11	11	0	7	1	1	0	2	0	0.0423	0.0592	1.000
17	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAT1(1), ACAT2(4), ECHS1(1), EHHADH(9), HADHB(1), SDS(2)	2494031	19	14	19	2	9	3	4	1	2	0	0.0699	0.0601	1.000
18	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), LPO(3), MPO(5), TPO(9)	2477193	19	17	19	3	9	4	1	0	5	0	0.114	0.0604	1.000
19	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	PTK2B(4), SHC1(2), SOS1(4), SRC(1)	2538395	11	11	11	0	7	0	2	1	1	0	0.0298	0.0690	1.000
20	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1)	3170618	17	17	17	2	7	5	2	1	2	0	0.0916	0.0692	1.000
21	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACAT2(4), ECHS1(1), EHHADH(9), SDHB(1), SDS(2)	2294765	18	13	18	2	9	2	4	1	2	0	0.0821	0.0723	1.000
22	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MYC(1), SP1(2), SP3(3), WT1(3)	1822652	9	9	9	0	6	0	1	1	1	0	0.0606	0.0728	1.000
23	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), EPX(2), LPO(3), MPO(5), MTHFR(1), SHMT1(1), SHMT2(2), TPO(9)	3390207	24	20	24	4	11	5	1	0	7	0	0.106	0.0987	1.000
24	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	148121	1	1	1	0	0	0	1	0	0	0	0.861	0.106	1.000
25	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), CDC42(2), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(2), WASL(1)	3974373	21	20	20	2	13	3	1	1	3	0	0.0450	0.107	1.000
26	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PDXK(1), PSAT1(2)	1403073	7	7	7	0	5	0	0	1	1	0	0.0980	0.113	1.000
27	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(7), GNB1(1), PRKACB(1), PRKAR2B(1), PRKCA(1)	2881981	12	12	10	1	6	2	1	0	3	0	0.168	0.115	1.000
28	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(1), ACO2(3), FH(2), IDH2(4), SDHB(1)	2382064	11	10	11	1	7	0	3	1	0	0	0.114	0.120	1.000
29	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), FH(2), IDH2(4), SDHA(3)	2790714	12	11	12	1	5	1	4	1	1	0	0.113	0.135	1.000
30	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), ADRB2(3), CFTR(5), GNAS(7), PRKACB(1), PRKAR2B(1)	3841220	20	18	18	2	8	4	5	0	3	0	0.111	0.137	1.000
31	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(1), GLI2(10), GLI3(6), GSK3B(2), PRKACB(1), PRKAR2B(1), SUFU(3)	4796862	26	25	26	4	4	8	7	2	5	0	0.185	0.145	1.000
32	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(4), GREB1(4), HSPB2(3), MTA1(1), PDZK1(1), TUBA8(2)	3337310	16	16	16	2	11	0	3	0	2	0	0.0553	0.172	1.000
33	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(3), ARHGEF1(1), F2(1), F2RL3(1), GNA13(2), GNAI1(2), GNB1(1), MAP3K7(1), PIK3CA(7), PIK3R1(2), PLCB1(7), PPP1R12B(1), PRKCA(1), PTK2B(4), ROCK1(3)	7570219	37	31	36	4	14	9	5	2	7	0	0.0247	0.183	1.000
34	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(3), PRKCA(1), PTK2B(4)	1952851	8	8	8	1	5	0	1	0	2	0	0.281	0.184	1.000
35	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB1A(1), RAB4A(2), RAB6A(1), RAB9A(1)	1265047	5	5	5	1	2	2	0	0	1	0	0.608	0.194	1.000
36	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA4(2), PSMA7(3), PSMB10(1), PSMB5(2), PSMB6(1), PSMB7(1), PSMB9(1)	2573799	12	10	12	1	5	2	5	0	0	0	0.133	0.199	1.000
37	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(2), IFNGR1(2), JAK1(2), JAK2(4), STAT1(2)	3370251	14	14	14	2	4	1	4	2	3	0	0.400	0.207	1.000
38	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD1(2), GLUD2(3)	1294013	6	6	6	1	5	0	1	0	0	0	0.313	0.210	1.000
39	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP8(1), CFL1(1), CFLAR(1)	1118316	4	4	4	1	1	0	1	0	2	0	0.690	0.215	1.000
40	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(2), GLS(1), GLUD1(2), OAT(2)	1712301	7	7	7	0	6	0	1	0	0	0	0.0734	0.234	1.000
41	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(1), ALAS2(1), CPOX(1), FECH(1), HMBS(2)	2296292	8	8	8	0	3	1	2	0	2	0	0.109	0.245	1.000
42	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(3), CAMK2A(3), CAMK2B(1), GNAS(7), MAPK1(1), MAPK14(2), PIK3CA(7), PIK3R1(2), PRKACB(1), PRKAR2B(1), PRKCA(1), RPS6KA1(1), RPS6KA5(1), SOS1(4)	8666303	35	32	32	3	20	6	4	0	5	0	0.00603	0.247	1.000
43	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	IFNG(2), IFNGR1(2), IKBKB(3), JAK2(4), NFKB1(2), NFKBIA(2), RELA(1), TNF(2), TNFRSF1A(1), USH1C(2), WT1(3)	4880567	24	22	24	3	11	3	6	1	3	0	0.0838	0.277	1.000
44	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(4), JAK3(3), MAPK1(1), STAT3(3), TYK2(2)	3547214	15	15	15	2	9	0	3	2	1	0	0.139	0.295	1.000
45	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	NTRK1(2), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), SHC1(2), SOS1(4)	4606812	21	21	20	3	15	2	0	1	3	0	0.0739	0.312	1.000
46	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), HEMK1(2), LCMT1(1), LCMT2(3), METTL2B(3), METTL6(1), PCYT1A(1), PCYT1B(1), PRMT6(2), PRMT7(1), PRMT8(1), WBSCR22(1)	4082724	18	17	18	2	9	4	2	1	2	0	0.113	0.329	1.000
47	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(2), BIRC3(1), CASP8(1), FADD(2), RIPK1(2), TNF(2), TNFRSF1A(1)	2418304	11	11	11	2	5	3	1	1	1	0	0.337	0.334	1.000
48	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(3), HDC(2), TH(2), TPH1(2)	1743742	9	9	9	2	4	1	0	1	3	0	0.429	0.339	1.000
49	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	EIF4A2(1), EIF4G1(4), EIF4G2(5), EIF4G3(4), MKNK1(1), PDK2(1), PIK3CA(7), PIK3R1(2), PPP2CA(1), RPS6KB1(1), TSC1(7), TSC2(9)	8078760	43	38	42	5	23	3	2	1	14	0	0.00823	0.340	1.000
50	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCL2(1), BCR(1), FOS(2), JAK2(4), JUN(1), MAP2K1(1), MAP2K4(3), MAP3K1(2), MYC(1), PIK3CA(7), PIK3R1(2), RAF1(1), SOS1(4), STAT1(2), STAT5A(2), STAT5B(1)	8152897	35	33	34	4	18	3	5	1	8	0	0.0328	0.347	1.000
51	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(1), F3(1), F5(4), FGA(6), PROC(1), PROS1(2), SERPINC1(2)	4889018	20	20	19	2	9	4	4	0	3	0	0.0543	0.350	1.000
52	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), IL6(2), LDLR(1), LPL(1)	1548631	5	5	5	1	2	1	2	0	0	0	0.533	0.355	1.000
53	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(4), APC(5), BTRC(1), DVL1(1), FZD1(1), GSK3B(2), NOTCH1(1), PSEN1(1), WNT1(2)	5395136	18	16	18	1	8	2	2	2	4	0	0.0182	0.359	1.000
54	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(2), CKB(1), CKMT1B(1), CKMT2(1), CPS1(6), GATM(1), GLUD1(2), NAGS(1), OAT(2), ODC1(1)	5495739	19	19	19	2	12	1	2	1	3	0	0.0589	0.370	1.000
55	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(3), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(3), GABRA6(3)	1927366	16	15	16	4	5	5	2	1	3	0	0.574	0.370	1.000
56	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	GSTZ1(1), HGD(1)	647836	2	2	2	1	0	1	1	0	0	0	0.881	0.379	1.000
57	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CBS(2), CTH(1), MUT(1)	1444692	5	5	5	1	2	0	1	0	2	0	0.596	0.381	1.000
58	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10RA(3), IL6(2), JAK1(2), STAT1(2), STAT3(3), STAT5A(2), TNF(2)	3627792	18	16	18	3	5	2	10	1	0	0	0.337	0.388	1.000
59	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD80(1), CD86(1), CTLA4(1), LCK(3), PIK3CA(7), PIK3R1(2), PTPN11(1)	3762261	16	14	15	2	7	4	3	0	2	0	0.182	0.410	1.000
60	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(2), ACO1(1), ACO2(3), FH(2), IDH2(4)	3658125	12	11	12	1	8	0	3	1	0	0	0.0851	0.446	1.000
61	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(2), CYP11A1(1), CYP11B1(1), CYP11B2(5), CYP17A1(1), CYP21A2(1)	2678385	11	11	11	2	7	3	1	0	0	0	0.204	0.461	1.000
62	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(2), CYP11A1(1), CYP11B1(1), CYP11B2(5), CYP17A1(1), CYP21A2(1)	2678385	11	11	11	2	7	3	1	0	0	0	0.204	0.461	1.000
63	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(4), FURIN(3), NOTCH1(1), PSEN1(1)	2773353	9	9	9	1	6	1	0	1	1	0	0.145	0.461	1.000
64	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(1), ALAS2(1), FECH(1), HMBS(2)	2507639	7	7	7	0	3	0	2	0	2	0	0.133	0.465	1.000
65	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(4), ERBB3(6), NRG1(2)	2976010	16	15	16	3	5	3	4	0	4	0	0.349	0.480	1.000
66	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT2(3), AKT3(1), MAPK1(1), PIK3CA(7), PIK3CD(4), PTK2B(4), RBL2(5), SHC1(2), SOS1(4)	5684276	31	27	30	4	19	4	1	2	5	0	0.0210	0.485	1.000
67	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2D3(2), UBE2J1(3), UBE2J2(1), UBE2L3(1), UBE2N(4), UBE2S(1), UBE3A(1)	3065851	13	12	13	2	6	4	2	0	1	0	0.228	0.488	1.000
68	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADS(1), ACAT1(1), ECHS1(1)	1600071	4	4	4	1	1	1	1	0	1	0	0.747	0.501	1.000
69	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(2), JUN(1), OPRK1(1), POLR2A(5), PRKACB(1), PRKAR2B(1)	3714962	11	11	11	0	4	0	5	0	2	0	0.0807	0.505	1.000
70	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS3(1), DHRS7(1), HEMK1(2), LCMT1(1), LCMT2(3), METTL2B(3), METTL6(1), PRMT6(2), PRMT7(1), PRMT8(1), WBSCR22(1)	4348313	17	16	17	2	9	4	2	0	2	0	0.119	0.521	1.000
71	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(2)	914461	2	2	2	1	0	0	1	1	0	0	0.909	0.521	1.000
72	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), ADRB2(3), GNAS(7), PLCE1(4), PRKACB(1), PRKAR2B(1)	4358835	19	15	17	2	10	4	4	0	1	0	0.0810	0.539	1.000
73	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), EGF(4), EGFR(4), PDGFRA(4), PRKCA(1), SH3GLB1(1), SH3KBP1(1), SRC(1)	5682635	17	16	17	2	7	0	5	1	4	0	0.119	0.555	1.000
74	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), COQ6(2)	1256106	3	3	3	0	1	0	0	1	1	0	0.464	0.556	1.000
75	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	SPCS1(1), SPCS3(1)	910568	2	2	2	1	2	0	0	0	0	0	0.802	0.569	1.000
76	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), SDHA(3), SDHB(1)	1917179	5	5	5	0	1	1	1	0	2	0	0.260	0.571	1.000
77	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	PIGB(1), PIGC(1), PIGL(2), PIGM(1), PIGN(2), PIGO(2), PIGQ(4), PIGS(2), PIGV(1), PIGW(1), PIGZ(2)	7309488	19	18	19	1	6	4	3	1	5	0	0.0482	0.586	1.000
78	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), FOS(2), JAK2(4), MAP2K1(1), PTPN6(1), RAF1(1), SHC1(2), SOS1(4), STAT5A(2), STAT5B(1)	5300798	19	18	19	2	11	2	2	2	2	0	0.0762	0.586	1.000
79	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACPP(4), ACPT(1), ENPP3(1), FLAD1(3), TYR(4)	2875643	14	12	14	3	6	1	5	1	1	0	0.384	0.601	1.000
80	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), NFKBIA(2), PLCB1(7), PRKCA(1), RELA(1)	2456755	13	13	13	3	6	3	2	0	2	0	0.398	0.606	1.000
81	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(1), GNA13(2), GNB1(1), PLCB1(7), PPP1R12B(1), PRKCA(1), ROCK1(3)	6086756	18	17	18	2	5	5	1	2	5	0	0.136	0.619	1.000
82	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(5), BTRC(1), CREBBP(6), CSNK2A1(1), DVL1(1), FZD1(1), GSK3B(2), MAP3K7(1), MYC(1), NLK(1), PPARD(1), PPP2CA(1), TLE1(4), WIF1(1), WNT1(2)	7898718	29	25	29	3	12	4	4	1	8	0	0.0171	0.626	1.000
83	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(1), CD4(1), IL1B(1), IL4(1), IL5RA(1), IL6(2)	1555243	8	7	8	2	1	4	2	0	1	0	0.593	0.635	1.000
84	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL4(1), JUNB(1), MAPK14(2), NFATC2(3), PRKACB(1), PRKAR2B(1)	3491444	9	9	9	0	4	1	2	1	1	0	0.0961	0.636	1.000
85	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(8), PRKACB(1), PRKAR2B(1)	2967227	10	10	10	2	3	1	1	1	4	0	0.435	0.637	1.000
86	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), EPX(2), LPO(3), MPO(5), PRDX1(1), PRDX2(1), SHMT1(1), SHMT2(2), TPO(9)	3479243	25	21	25	5	10	5	2	0	8	0	0.199	0.639	1.000
87	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(2), IL6R(1), JAK1(2), JAK2(4), JAK3(3), SRC(1), STAT3(3)	4542489	18	17	18	3	7	1	5	2	3	0	0.321	0.640	1.000
88	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1)	507526	1	1	1	1	1	0	0	0	0	0	0.886	0.643	1.000
89	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2)	1646154	4	4	4	1	1	1	0	0	2	0	0.735	0.649	1.000
90	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(1), CRY1(3), CSNK1E(2), PER1(2)	2474644	9	9	9	2	5	0	3	1	0	0	0.385	0.662	1.000
91	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CAPN1(1), CAPNS1(1), GSK3B(2), MAPT(3), PPP2CA(1)	2880122	10	10	10	2	5	0	1	1	3	0	0.280	0.670	1.000
92	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1), PRKCA(1), TGM2(1)	1506101	4	4	4	1	3	0	1	0	0	0	0.528	0.672	1.000
93	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	14	CHST11(1), CHST12(1), CHST13(1), SULT1A2(1), SULT2B1(2), SUOX(2)	3379204	8	8	8	1	4	2	0	0	2	0	0.289	0.674	1.000
94	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT2(3), AKT3(1), CAB39(1), HIF1A(1), MAPK1(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PRKAA1(3), RICTOR(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), TSC1(7), TSC2(9), ULK1(2), ULK2(6), VEGFC(3)	15924968	77	58	76	9	36	10	8	2	21	0	0.000767	0.675	1.000
95	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), CYP11B2(5), CYP17A1(1)	2037209	7	7	7	2	3	3	1	0	0	0	0.500	0.677	1.000
96	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(1)	593087	1	1	1	0	1	0	0	0	0	0	0.664	0.695	1.000
97	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2)	3923945	12	12	12	2	5	2	2	0	3	0	0.319	0.698	1.000
98	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP2E1(1), PTGS1(1), PTGS2(1)	1543342	3	3	3	2	0	0	0	0	3	0	0.932	0.701	1.000
99	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(4), CHKA(1), PCYT1A(1), PDHA1(1), PDHA2(3)	1972710	11	10	11	3	7	3	1	0	0	0	0.361	0.703	1.000
100	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	EIF4A2(1), EIF4G1(4), EIF4G2(5), EIF4G3(4), GHR(1), MAPK1(1), MAPK14(2), MKNK1(1), PABPC1(1), PDK2(1), PIK3CA(7), PIK3R1(2), PRKCA(1), RPS6KB1(1)	8149154	32	29	31	4	23	2	2	0	5	0	0.00976	0.704	1.000
101	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1), SQLE(1)	980074	2	2	2	1	1	0	0	1	0	0	0.820	0.706	1.000
102	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(2), FUT9(2), ST8SIA1(1)	1800286	5	4	5	1	0	1	3	0	1	0	0.636	0.707	1.000
103	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	CDKN2A(1), E2F1(1), MDM2(1), MYC(1), PIK3CA(7), PIK3R1(2), POLR1A(1), TBX2(3)	5067041	17	17	16	3	7	3	3	1	3	0	0.296	0.709	1.000
104	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(8), RANGAP1(2)	2364374	10	8	10	2	4	3	1	0	2	0	0.479	0.726	1.000
105	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	19	CSNK2A1(1), FOS(2), IL6(2), IL6R(1), JAK1(2), JAK2(4), JAK3(3), JUN(1), MAP2K1(1), PTPN11(1), RAF1(1), SHC1(2), SOS1(4), STAT3(3)	6496466	28	26	28	4	16	0	6	3	3	0	0.0722	0.726	1.000
106	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(1)	860076	2	2	2	0	0	2	0	0	0	0	0.610	0.731	1.000
107	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(2)	1150945	2	2	2	1	0	1	0	0	1	0	0.932	0.733	1.000
108	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), GGPS1(1), SQLE(1)	1293264	3	3	3	1	2	0	0	1	0	0	0.669	0.748	1.000
109	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYA(1), SP1(2), SP3(3)	1446887	6	6	6	2	3	0	1	1	1	0	0.670	0.756	1.000
110	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(4), ERBB4(4), NRG2(1), NRG3(2), PRKCA(1), PSEN1(1)	2651073	13	13	13	3	6	4	2	1	0	0	0.411	0.759	1.000
111	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(1), CCNB1(1), CCND2(1), CCNE1(1), CCNH(1), CDK7(1), CDKN2A(1), E2F1(1), RBL1(3), TFDP1(1)	4031890	12	12	12	2	6	2	3	0	1	0	0.272	0.774	1.000
112	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(1), MBTPS1(2), MBTPS2(1), SCAP(2), SREBF1(4), SREBF2(2)	3628786	14	14	14	3	6	3	1	0	4	0	0.338	0.774	1.000
113	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), NFKB1(2), NOX1(3), RELA(1), TNF(2), XDH(4)	2982163	14	13	14	3	8	2	4	0	0	0	0.278	0.779	1.000
114	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(2), CTH(1), DNMT1(3), DNMT3A(2), MARS(3), MARS2(1), MAT1A(3), MTR(1)	5155431	16	13	16	2	3	4	2	3	4	0	0.193	0.783	1.000
115	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), JUN(1), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K1(2), MAPK1(1), MAPK14(2), PAK1(1), PLCG1(3), PRKCA(1), PTK2B(4), RAF1(1), SHC1(2), SOS1(4), SRC(1)	8351072	31	30	31	4	18	2	5	1	5	0	0.0441	0.786	1.000
116	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC3B(1), APOBEC3G(1), APOBEC4(1)	2152263	4	4	4	1	0	1	1	0	2	0	0.750	0.796	1.000
117	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(3), ACTN2(2), BCAR1(2), CTNNA1(1), CTNNA2(3), PTK2(6), PXN(1), SRC(1), VCL(3)	5224285	22	20	22	4	8	7	4	0	3	0	0.201	0.802	1.000
118	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), LCT(4), MPI(1), PYGL(1), PYGM(5)	4080705	12	12	12	2	7	2	0	0	3	0	0.198	0.805	1.000
119	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), TYR(4)	1371416	5	5	5	2	1	0	4	0	0	0	0.834	0.807	1.000
120	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CDKN2A(1), CFL1(1), E2F1(1), MDM2(1)	2063723	4	3	4	1	0	0	3	1	0	0	0.805	0.810	1.000
121	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(7), GNB1(1), PRKACA(1)	1934829	12	11	10	3	6	3	2	0	1	0	0.530	0.817	1.000
122	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	6	CDK7(1), CHEK1(1), WEE1(2)	2154228	4	4	4	0	2	1	0	0	1	0	0.333	0.823	1.000
123	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), UGDH(1)	1187791	2	2	2	0	1	0	0	0	1	0	0.556	0.826	1.000
124	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(1), GPI(2), HK1(1), PFKL(1), PGAM1(1)	2697414	8	8	8	2	3	1	0	0	4	0	0.574	0.831	1.000
125	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	HDAC9(6), MEF2A(3), MEF2C(1), MEF2D(1), MYOD1(3), YWHAH(1)	2526001	15	15	15	4	5	4	3	1	2	0	0.430	0.831	1.000
126	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	GH1(1), GHR(1), IGF1R(6), PIK3CA(7), PIK3R1(2), SHC1(2)	3838313	19	18	18	4	11	2	2	1	3	0	0.227	0.838	1.000
127	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	DOCK1(6), FOS(2), GAB1(3), HGF(5), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(1), MAP2K2(2), MAP4K1(1), MAPK1(1), PAK1(1), PIK3CA(7), PIK3R1(2), PTK2(6), PTK2B(4), PTPN11(1), PXN(1), RAF1(1), RAP1A(1), RASA1(4), SOS1(4), SRC(1), STAT3(3)	13165875	62	49	61	7	36	8	10	2	6	0	0.000966	0.842	1.000
128	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), FMOD(1), LUM(1)	1052911	4	4	4	2	2	0	1	0	1	0	0.926	0.850	1.000
129	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA4(2), PSMA7(3), PSMB5(2), PSMB6(1), PSMB7(1), PSMD14(1), UBE3A(1)	3907545	12	9	12	2	5	2	5	0	0	0	0.286	0.853	1.000
130	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(4), EGFR(4), HGS(3), TF(1), TFRC(1)	3742601	15	15	15	4	3	1	5	0	6	0	0.705	0.862	1.000
131	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(2), AOC3(1), CES1(1)	1778939	4	4	4	0	2	0	2	0	0	0	0.298	0.864	1.000
132	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), POLR3A(1), POLR3B(1)	6830089	15	15	15	1	7	2	2	0	4	0	0.0701	0.867	1.000
133	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(3), BCL2(1), FASLG(1), HSPB2(3), MAPKAPK2(1), MAPKAPK3(1), TNF(2)	3250488	12	12	12	3	5	1	2	0	4	0	0.395	0.871	1.000
134	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), ACAT2(4)	1001643	5	5	5	3	2	0	2	0	1	0	0.892	0.879	1.000
135	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), EHHADH(9), HADH(1), SIRT2(2), VNN2(2)	3502517	15	10	15	2	10	2	2	1	0	0	0.0951	0.880	1.000
136	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(1), CKS1B(1), CUL1(1), E2F1(1), SKP2(1), TFDP1(1)	1999959	6	6	6	2	2	0	2	0	2	0	0.750	0.882	1.000
137	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFA5(1), NDUFV2(1)	2079183	3	3	3	1	1	2	0	0	0	0	0.737	0.890	1.000
138	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(2), CNR2(1), DNMT1(3), MTNR1A(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGIR(2)	3229046	12	11	12	3	7	2	1	1	1	0	0.292	0.891	1.000
139	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(2), POLE(3), POLG(4), POLQ(7)	4895348	16	16	16	3	8	5	1	1	1	0	0.250	0.893	1.000
140	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD2(1), GRM1(3), PLCB1(7), PPP1CA(2), PPP1R1B(1), PPP2CA(1), PPP3CA(4), PRKACB(1), PRKAR2B(1)	4703206	21	17	21	4	12	4	3	0	2	0	0.150	0.893	1.000
141	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(1), CCNE1(1), CUL1(1), E2F1(1), SKP2(1), TFDP1(1)	2036185	6	6	6	2	3	0	2	0	1	0	0.743	0.897	1.000
142	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(6), PAX3(2), PML(1), RARA(1), TNF(2), TNFRSF1A(1)	4734910	13	13	13	2	7	2	2	1	1	0	0.183	0.902	1.000
143	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), UGDH(1)	1491522	2	2	2	0	1	0	0	0	1	0	0.556	0.908	1.000
144	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(7), CHEK1(1), MYT1(4), WEE1(2), YWHAH(1)	4056924	15	14	15	3	4	3	4	2	2	0	0.417	0.914	1.000
145	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), DUSP14(1), IFNG(2), IFRD1(1), IL18(2), IL1R1(3), JUND(1), NR4A3(2)	3243137	13	12	13	3	5	1	4	0	3	0	0.388	0.917	1.000
146	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(1), GALNT1(2), GALNT11(1), GALNT12(2), GALNT13(1), GALNT14(1), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(3), GALNT8(2), GALNTL5(2), GCNT3(1), ST3GAL1(1), ST6GALNAC1(3), WBSCR17(5)	9431722	30	29	29	4	14	8	5	2	1	0	0.0462	0.926	1.000
147	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(6), EP300(3), ESR1(4), MAPK1(1), PELP1(4), SRC(1)	4411433	19	16	19	4	11	1	4	0	3	0	0.172	0.927	1.000
148	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(1), RDH12(1), RDH13(1), RDH14(1)	1351019	5	5	5	3	3	0	1	0	1	0	0.886	0.927	1.000
149	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(2), IL6(2), KITLG(2), TGFB2(2), TGFB3(2)	2539008	11	11	11	3	6	0	3	0	2	0	0.437	0.927	1.000
150	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(1), EIF2B5(1), EIF2S3(1), GSK3B(2), PPP1CA(2)	3375726	9	9	9	2	6	0	0	1	2	0	0.307	0.929	1.000
151	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT3(1), GALNT4(2), GALNT6(3), GALNT8(2), ST3GAL1(1), WBSCR17(5)	4298000	16	15	16	3	6	4	3	2	1	0	0.271	0.930	1.000
152	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT2(3), AKT3(1), ANKRD6(1), APC(5), AXIN2(3), CER1(2), DACT1(3), DKK1(1), DKK2(2), DKK3(2), DVL1(1), GSK3B(2), LRP1(12), NKD1(1), NKD2(1), PIN1(1), PSEN1(1), PTPRA(2), SENP2(4), WIF1(1)	10997992	49	40	49	6	17	10	9	2	11	0	0.0132	0.931	1.000
153	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(1), FCGR3A(1), IL1B(1), IL6R(1), SELL(1), SPN(1), TGFB2(2), TNF(2), TNFRSF1A(1), TNFRSF8(1)	4094494	14	13	14	3	4	2	2	3	3	0	0.441	0.932	1.000
154	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2(1), CBL(1), CFLAR(1), E2F1(1), FOS(2), IL2RB(3), JAK1(2), JAK3(3), MAPK1(1), MYC(1), NMI(2), PIK3CA(7), PIK3R1(2), PTPN6(1), RAF1(1), RPS6KB1(1), SHC1(2), SOS1(4), STAT5A(2), STAT5B(1), SYK(1)	10643774	40	38	39	5	24	5	5	2	4	0	0.00940	0.935	1.000
155	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(2), ALPPL2(1), FPGS(2)	2020809	6	6	6	2	3	2	0	0	1	0	0.712	0.936	1.000
156	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), CDC42(2), WASL(1)	2421908	7	7	7	2	5	1	0	0	1	0	0.528	0.938	1.000
157	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(1), SHMT2(2)	1275936	3	3	3	2	1	1	0	0	1	0	0.901	0.945	1.000
158	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), JAK1(2), JAK2(4), JAK3(3), STAT1(2), STAT3(3), STAT5A(2), STAT5B(1), TYK2(2)	5610370	22	20	22	4	10	2	6	2	2	0	0.224	0.945	1.000
159	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(2), IMPDH1(2), POLD1(2), POLG(4), PRPS2(1), RRM1(1), SRM(2)	3783007	15	12	15	3	7	3	3	0	2	0	0.227	0.946	1.000
160	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(1), CUL1(1), E2F1(1), FBXW7(1), TFDP1(1)	1972422	5	5	5	2	1	1	2	0	1	0	0.887	0.949	1.000
161	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(1), BMPR1B(1), BMPR2(3)	1813138	5	4	5	2	3	0	0	0	2	0	0.636	0.949	1.000
162	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2B(2), GTF2E1(1), HDAC3(1), NCOA1(2), NCOA2(4), NCOA3(6), NCOR2(6), POLR2A(5), RARA(1), RXRA(5)	7390105	36	31	36	6	16	6	4	2	8	0	0.0886	0.950	1.000
163	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(3), ASAH1(1), GNAI1(2), GNB1(1), ITGAV(4), MAPK1(1), PDGFA(1), PDGFRA(4), PIK3CA(7), PIK3R1(2), PLCB1(7), PRKCA(1), PTK2(6), SMPD2(2), SPHK1(2), SRC(1)	7972604	45	40	44	8	20	9	8	1	7	0	0.0950	0.951	1.000
164	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(8), C5(3), C6(1), C7(1), C9(2)	3762282	15	14	15	5	6	1	2	1	5	0	0.710	0.952	1.000
165	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(2), FYN(1), JUN(1), MAPK14(2), THBS1(3)	2078065	10	10	10	3	5	1	3	1	0	0	0.551	0.953	1.000
166	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA2B(2), ADORA3(2), LTB4R(1), P2RY1(4), P2RY6(1)	1643211	11	11	11	4	2	3	5	1	0	0	0.697	0.958	1.000
167	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT2(3), AKT3(1), MAP2K1(1), MAP2K2(2), NGFR(1), NTRK1(2), PIK3CA(7), PIK3CD(4), SHC1(2), SOS1(4)	4806927	27	24	26	5	19	4	2	1	1	0	0.0810	0.959	1.000
168	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(2), CTH(1), MARS(3), MARS2(1), MAT1A(3), SCLY(2), SEPHS1(1)	3680358	13	10	13	3	3	4	1	2	3	0	0.486	0.960	1.000
169	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CBS(2), CTH(1), DNMT1(3), DNMT3A(2), MARS(3), MARS2(1), MAT1A(3), MTAP(1), MTR(1), SRM(2)	6152937	19	16	19	3	5	4	2	3	5	0	0.178	0.965	1.000
170	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(7), ATR(6), CHEK1(1), CHEK2(2), YWHAH(1)	4378413	17	14	17	3	2	3	6	3	3	0	0.505	0.966	1.000
171	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(1), BIRC3(1), CASP8(1), DFFB(1), GZMB(1), PRF1(3), SCAP(2), SREBF1(4), SREBF2(2)	5481130	19	17	19	6	5	4	1	1	8	0	0.698	0.967	1.000
172	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), NCKAP1(2), NTRK1(2), PSMA7(3), WASF2(2), WASF3(2), WASL(1)	4513810	16	14	16	3	13	2	1	0	0	0	0.124	0.968	1.000
173	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	SULT1A2(1), SUOX(2)	2497699	3	3	3	0	3	0	0	0	0	0	0.304	0.969	1.000
174	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SRP72(2)	2205265	4	3	4	2	1	1	0	0	2	0	0.925	0.970	1.000
175	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(2), FUT9(2), GBGT1(1), GLA(1), HEXA(1), NAGA(2), ST3GAL1(1), ST8SIA1(1)	2904994	11	10	11	3	1	1	7	0	2	0	0.711	0.970	1.000
176	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT3(2), AGPAT4(1), AGPAT6(2), CHPT1(1), ENPP2(1), ENPP6(2), PAFAH2(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLD1(2), PLD2(2), PPAP2A(3), PPAP2C(3)	6951113	36	31	36	6	19	6	4	1	6	0	0.0261	0.971	1.000
177	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(2), FUT3(1)	1483211	3	3	3	4	0	0	2	0	1	0	0.991	0.971	1.000
178	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	APC(5), DVL1(1), FZD1(1), GJA1(2), GNAI1(2), GSK3B(2), IRAK1(2), LBP(2), LEF1(2), LY96(1), MYD88(1), NFKB1(2), PIK3CA(7), PIK3R1(2), PPP2CA(1), RELA(1), TLR4(2), WNT1(2)	8233734	38	35	37	7	21	5	3	1	8	0	0.0516	0.972	1.000
179	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), IL4R(1), JAK1(2), JAK2(4), TYK2(2)	3062068	12	11	12	3	5	0	3	2	2	0	0.553	0.973	1.000
180	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), IL4R(1), JAK1(2), JAK2(4), TYK2(2)	3062068	12	11	12	3	5	0	3	2	2	0	0.553	0.973	1.000
181	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(1), ST3GAL1(1)	2243377	6	6	6	4	2	1	1	0	2	0	0.957	0.976	1.000
182	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), IFNG(2), IFNGR1(2), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), IL18(2), IL18R1(1), IL4(1), IL4R(1)	3720452	23	21	23	5	9	2	6	1	5	0	0.276	0.976	1.000
183	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), ACAT2(4), BDH1(1), BDH2(1), HMGCS1(2)	2237166	9	9	9	3	4	1	2	0	2	0	0.639	0.977	1.000
184	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(1), PDHA1(1), PDHA2(3), PDHB(1)	2944139	8	8	8	2	6	2	0	0	0	0	0.402	0.977	1.000
185	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), CAMP(1), ITPKB(1)	1737280	3	3	3	5	2	0	0	0	1	0	0.999	0.977	1.000
186	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), LDHA(1)	1955458	2	2	2	1	2	0	0	0	0	0	0.750	0.978	1.000
187	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(2), CASP8(1), GZMB(1), JUN(1), PRF1(3)	3717936	11	11	11	4	3	3	1	0	4	0	0.764	0.979	1.000
188	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(2), CYP2A6(1), CYP2A7(3), XDH(4)	2366780	10	9	10	3	4	3	3	0	0	0	0.568	0.980	1.000
189	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(1), B4GALT2(1), B4GALT3(2), CHST1(1), CHST2(3), FUT8(1), ST3GAL1(1)	3444297	11	11	11	4	4	1	2	0	4	0	0.710	0.981	1.000
190	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), LCT(4), MAN2C1(2), NEU1(3), NEU2(3), NEU3(2)	4977294	19	17	19	4	12	2	5	0	0	0	0.175	0.981	1.000
191	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	CLTB(1), COPA(4), GBF1(2)	4752734	7	7	7	1	5	1	1	0	0	0	0.269	0.981	1.000
192	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), SHMT1(1), SHMT2(2)	1705440	4	4	4	2	2	1	0	0	1	0	0.816	0.982	1.000
193	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(3), BCL2(1), BIK(1), BIRC2(1), BIRC3(1), CASP6(1), CASP8(1), DFFB(1), ENDOG(1)	3956668	11	10	11	4	3	1	1	2	4	0	0.804	0.983	1.000
194	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), PRKCA(1), PTPRA(2), SRC(1)	2716276	5	5	5	2	2	0	2	0	1	0	0.757	0.984	1.000
195	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(3), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(3), GABRA6(3), GPHN(5), SRC(1), UBQLN1(1)	3754073	23	22	23	6	6	6	6	1	4	0	0.601	0.985	1.000
196	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), GZMB(1), ICAM1(1), ITGAL(3), ITGB2(2), PRF1(3)	2505960	11	11	11	4	5	2	2	0	2	0	0.569	0.985	1.000
197	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(4), ESR2(1), PDE1A(1), PDE1B(1), PLCB1(7), PLCB2(2), PRL(2)	3252940	18	16	18	5	7	5	3	0	3	0	0.428	0.986	1.000
198	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	EIF2B5(1), EIF2S3(1), GSK3B(2), IGF1R(6), INPPL1(3), PDK2(1), PIK3CA(7), PIK3R1(2), PPP2CA(1), RPS6KB1(1)	5763859	25	23	24	5	11	3	3	1	7	0	0.150	0.986	1.000
199	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(2), JUN(1), MAP2K1(1), MAPK1(1), MYC(1), NFKB1(2), NFKBIA(2), PLCB1(7), PRKCA(1), RAF1(1), RELA(1), TNF(2)	4502795	24	23	24	5	14	3	5	0	2	0	0.171	0.986	1.000
200	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), BIRC2(1), BIRC3(1), CASP4(3), CASP6(1), CASP8(1), DFFB(1), GZMB(1), LMNA(2), LMNB1(1), LMNB2(2), PRF1(3)	5690472	20	19	20	6	5	4	3	1	7	0	0.620	0.986	1.000
201	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(4), AASS(2)	2030586	7	7	7	4	4	0	1	1	1	0	0.890	0.987	1.000
202	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD4(1), IL6(2), KITLG(2)	1840363	5	5	5	3	2	1	1	0	1	0	0.914	0.987	1.000
203	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), CDK7(1), ERCC3(3), GTF2B(2), GTF2E1(1), POLR1A(1), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), POLR3B(1), POLR3D(1), POLR3E(1), TAF5(1)	10440897	25	24	25	3	10	4	2	0	9	0	0.0660	0.987	1.000
204	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), FOS(2), JAK1(2), JUN(1), MAP2K1(1), MAP2K4(3), MAP3K1(2), PDGFA(1), PDGFRA(4), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SHC1(2), SOS1(4), STAT1(2), STAT3(3), STAT5A(2)	10354864	48	45	47	8	24	3	8	4	9	0	0.0674	0.987	1.000
205	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CXCR3(1), IFNG(2), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), IL18(2), IL18R1(1), JAK2(4), JUN(1), MAPK14(2), STAT4(3), TYK2(2)	5547864	31	29	31	6	15	3	6	2	5	0	0.111	0.988	1.000
206	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), FOS(2), JAK2(4), JUN(1), MAP2K1(1), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SHC1(2), SOS1(4), STAT1(2), STAT3(3), STAT5A(2), STAT5B(1)	8865450	41	37	40	7	22	3	5	3	8	0	0.0922	0.990	1.000
207	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(3), BCL2(1), CSF2RB(1), IGF1R(6), KIT(5), KITLG(2), PIK3CA(7), PIK3R1(2), PRKACB(1), PRKAR2B(1), YWHAH(1)	6426341	30	24	29	6	11	5	5	1	8	0	0.227	0.990	1.000
208	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(2), CYP2C18(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP3A4(1), CYP3A43(1), CYP3A5(3), CYP3A7(1), HSD3B7(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), RDH12(1), RDH13(1), RDH14(1)	7175361	30	29	30	9	10	5	3	3	9	0	0.512	0.990	1.000
209	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), IL18(2), ITGB1(1), MAP2K1(1), PAK1(1), PIK3CA(7), PIK3R1(2), PTK2B(4), PTPN6(1), SYK(1), VAV1(3)	5587751	24	21	23	8	11	4	2	1	6	0	0.624	0.991	1.000
210	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(4), EGFR(4), FOS(2), JAK1(2), JUN(1), MAP2K1(1), MAP2K4(3), MAP3K1(2), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SHC1(2), SOS1(4), STAT1(2), STAT3(3), STAT5A(2)	11089109	51	49	50	9	23	3	10	3	12	0	0.101	0.992	1.000
211	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CHUK(2), GH1(1), GHR(1), NFKB1(2), NFKBIA(2), PIK3CA(7), PIK3R1(2), PPP2CA(1), RELA(1), YWHAH(1)	4323935	20	19	19	7	11	3	1	1	4	0	0.639	0.992	1.000
212	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGAL(3), ITGB2(2), PTPRC(4)	3080098	10	10	10	3	8	0	2	0	0	0	0.460	0.992	1.000
213	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(1), EPX(2), HPD(2), LPO(3), MAOA(2), MAOB(2), MPO(5), PRDX1(1), PRDX2(1), TPO(9)	6479720	33	28	33	7	14	5	7	0	7	0	0.155	0.992	1.000
214	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(3), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A9(1), UGT2B15(1), UGT2B4(4)	5102912	17	14	17	7	7	1	3	1	5	0	0.883	0.993	1.000
215	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(4), MAP2K1(1), MAP3K1(2), MAPK14(2), NCOR2(6), RARA(1), RXRA(5)	5137363	25	23	25	5	13	2	5	1	4	0	0.202	0.993	1.000
216	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(1), CTH(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), SDS(2), SULT1C4(1)	3679992	8	8	8	3	3	1	0	1	3	0	0.750	0.993	1.000
217	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(1), HADH(1), HADHB(1), PPT2(2)	2535795	5	5	5	2	3	1	1	0	0	0	0.682	0.993	1.000
218	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(6), DFFB(1), GZMA(1), GZMB(1), HMGB2(1), NME1(1), PRF1(3)	3124411	16	15	16	6	6	2	4	1	3	0	0.695	0.993	1.000
219	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(1), MMP2(1), MMP9(1), RECK(2), TIMP4(3)	2206197	8	7	8	3	3	2	2	0	1	0	0.776	0.994	1.000
220	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), FUT1(2), FUT3(1)	2100062	4	4	4	3	0	0	3	0	1	0	0.954	0.994	1.000
221	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), RPL10A(1), RPL10L(1), RPL11(1), RPL13(1), RPL18(1), RPL23A(1), RPL27(1), RPL3(1), RPL36A(1), RPS10(1), RPS23(1), RPS3(1), RPS4Y1(2), RPS9(1)	6305597	16	14	16	3	9	2	0	1	4	0	0.294	0.994	1.000
222	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNE1(1), CCNE2(1), CDKN2A(1), E2F1(1)	2605762	5	5	5	2	1	0	4	0	0	0	0.828	0.994	1.000
223	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	IGF1R(6), MAP2K1(1), MAPK1(1), PIK3CA(7), PIK3R1(2), RAF1(1), SHC1(2), SOS1(4), YWHAH(1)	5502682	25	22	24	5	16	2	3	2	2	0	0.150	0.995	1.000
224	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(2), CTH(1), HEMK1(2), LCMT1(1), LCMT2(3), MARS(3), MARS2(1), MAT1A(3), METTL2B(3), METTL6(1), PRMT6(2), PRMT7(1), PRMT8(1), SCLY(2), SEPHS1(1), SEPHS2(1), WBSCR22(1)	7315632	29	24	29	5	12	7	3	2	5	0	0.146	0.995	1.000
225	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(2), JAK2(4), JAK3(3)	4151864	11	11	11	3	5	1	1	2	2	0	0.616	0.995	1.000
226	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	DDX20(1), E2F1(1), ETS1(1), ETS2(1), ETV3(1), FOS(2), HDAC2(1), JUN(1), NCOR2(6), RBL1(3), RBL2(5), SIN3A(2), SIN3B(1)	7915380	26	21	26	4	13	1	5	1	6	0	0.0913	0.995	1.000
227	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(5), ABCB11(2), ABCB4(2), ABCC3(4), GSTP1(2)	4276100	15	13	15	4	7	4	2	1	1	0	0.433	0.996	1.000
228	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1)	2396715	1	1	1	4	0	0	0	0	1	0	0.998	0.996	1.000
229	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS3(1), DHRS7(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(1)	4760344	8	8	8	2	3	2	2	0	1	0	0.486	0.997	1.000
230	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	IL1B(1), MST1R(2), TNF(2)	1877861	5	4	5	3	2	0	2	0	1	0	0.813	0.997	1.000
231	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(2), ACOX3(1), ELOVL2(1), FASN(10), PECR(2)	4488218	17	15	17	9	9	1	0	3	4	0	0.886	0.997	1.000
232	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOA4(1), APOC3(1), CYP7A1(1), DGAT1(2), HMGCR(4), LDLR(1), LIPC(2), LPL(1), LRP1(12), SCARB1(1)	7940072	32	28	32	5	17	6	4	1	4	0	0.0571	0.997	1.000
233	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS3(1), DHRS7(1), HSD3B7(1), PON3(1), RDH12(1), RDH13(1), RDH14(1)	2593667	7	6	7	3	3	1	2	0	1	0	0.815	0.997	1.000
234	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	MAPK1(1), MAPK7(4), MEF2A(3), MEF2C(1), MEF2D(1), NTRK1(2), PIK3CA(7), PIK3R1(2), PLCG1(3), RPS6KA1(1), SHC1(2)	5843622	27	25	26	6	15	4	3	1	4	0	0.209	0.997	1.000
235	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(2), EPHB2(4), F2(1), F2RL3(1), JUN(1), MAPK1(1), MAPK7(4), MYEF2(1), PLD1(2), PLD2(2), PLD3(3), PTK2(6), RAF1(1), RASAL1(3), SRC(1), VAV1(3)	8095072	37	31	37	6	18	6	10	1	2	0	0.0532	0.997	1.000
236	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK2A(3), CAMK2B(1), CAMKK2(1)	3492392	5	5	5	2	1	1	0	0	3	0	0.715	0.998	1.000
237	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), JAK1(2), STAT1(2), STAT2(1), TYK2(2)	3199729	9	9	9	3	3	0	3	2	1	0	0.727	0.998	1.000
238	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BCL10(1), BCL2(1), CES1(1)	3424506	6	6	6	3	3	1	0	0	2	0	0.792	0.998	1.000
239	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), FOS(2), JUN(1), MAPK14(2), PLCG1(3), PRKCA(1), PTK2B(4)	3962562	14	14	14	4	9	0	3	0	2	0	0.443	0.998	1.000
240	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	IFNG(2), IL4(1), TGFB2(2), TGFB3(2), TGFBR1(1), TOB1(1)	3170549	9	9	9	3	3	0	5	0	1	0	0.750	0.998	1.000
241	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), FDXR(1), SHMT1(1)	4722513	12	12	12	3	2	1	4	1	4	0	0.765	0.998	1.000
242	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	10	GRIN1(3), HIF1A(1), JAK2(4), NFKB1(2), NFKBIA(2), RELA(1)	3743365	13	12	13	5	7	0	2	1	3	0	0.753	0.998	1.000
243	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	A1BG(5), AKT2(3), AKT3(1), BTK(1), CDKN2A(1), DAPP1(1), GSK3B(2), IARS(1), PIK3CA(7), PPP1R13B(5), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KB1(1), SHC1(2), SOS1(4), SOS2(2), YWHAE(2), YWHAH(1), YWHAZ(1)	10247310	50	42	49	9	26	6	8	4	6	0	0.0430	0.998	1.000
244	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(2), ASS1(2), CKB(1), CKMT1B(1), CKMT2(1), CPS1(6), DAO(5), EPRS(3), GATM(1), GLUD1(2), GLUD2(3), LAP3(1), NOS1(9), NOS3(2), OAT(2), P4HA2(2), P4HA3(1), PARS2(1)	10937130	45	39	45	8	23	9	6	1	6	0	0.0370	0.998	1.000
245	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(1), INSR(6), JAK2(4), MAP2K1(1), MAPK1(1), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), PTPN6(1), RAF1(1), RPS6KA1(1), SHC1(2), SLC2A4(1), SOS1(4), STAT5A(2), STAT5B(1)	9788207	40	34	39	7	24	5	2	2	7	0	0.0438	0.998	1.000
246	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD4(1), CXCR3(1), IFNG(2), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), JAK2(4), STAT4(3), TYK2(2)	4420412	26	25	26	7	11	4	6	1	4	0	0.374	0.998	1.000
247	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), GPT(1), LDHA(1), MAPK14(2), NCL(1)	2675956	7	6	7	3	3	0	2	1	1	0	0.795	0.998	1.000
248	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH5(1), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1)	3918647	8	8	8	4	1	3	1	0	3	0	0.916	0.998	1.000
249	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(2), ALOX5(2), LTA4H(1), PLA2G6(1), PTGES(1), PTGS1(1), PTGS2(1), TBXAS1(1)	4593030	10	10	10	7	3	1	1	1	4	0	0.972	0.998	1.000
250	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(2), NFKB1(2), NFKBIA(2), RELA(1)	2753164	7	7	7	5	4	1	1	0	1	0	0.953	0.998	1.000
251	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(2), CP(2), CPOX(1), EPRS(3), FECH(1), GUSB(3), HCCS(1), HMBS(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A9(1), UGT2B15(1), UGT2B4(4)	7995806	28	25	28	9	8	3	8	1	8	0	0.767	0.998	1.000
252	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL4(1), IL4R(1), JAK1(2), JAK3(3), RPS6KB1(1), SHC1(2), STAT6(1)	4322510	11	11	11	3	5	0	3	2	1	0	0.571	0.999	1.000
253	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), FUT1(2), FUT9(2), GBGT1(1), GLA(1), HEXA(1), NAGA(2), ST3GAL1(1), ST8SIA1(1)	3079349	12	11	12	4	1	1	8	0	2	0	0.801	0.999	1.000
254	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(1), GPR161(3), GPR34(1), GPR45(1), GPR65(1), GPR68(1)	2856796	9	9	9	6	4	1	2	1	1	0	0.947	0.999	1.000
255	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	13	APAF1(3), ATM(7), BCL2(1), CCNE1(1), E2F1(1), MDM2(1)	4436306	14	14	14	4	3	1	5	2	3	0	0.635	0.999	1.000
256	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	CABIN1(5), IGF1R(6), INSR(6), MAPK14(2), MAPK7(4), MEF2A(3), MEF2C(1), MEF2D(1), MYOD1(3), NFATC2(3), PIK3CA(7), PIK3R1(2), PPP3CA(4), YWHAH(1)	10189356	48	37	47	9	28	6	7	2	5	0	0.0274	0.999	1.000
257	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), F2RL3(1), GNAI1(2), GNB1(1), ITGA1(3), ITGB1(1), MAP2K1(1), MAPK1(1), PLA2G4A(5), PLCB1(7), PRKCA(1), PTGS1(1), PTK2(6), RAF1(1), SRC(1), SYK(1), TBXAS1(1)	7147151	35	32	35	7	15	8	7	1	4	0	0.160	0.999	1.000
258	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	CHUK(2), CRADD(1), IKBKB(3), JUN(1), LTA(1), MAP2K4(3), MAP3K1(2), MAP4K2(1), MAPK14(2), NFKB1(2), NFKBIA(2), RELA(1), RIPK1(2), TNF(2), TNFRSF1A(1)	7342117	26	25	26	5	13	4	5	0	4	0	0.230	0.999	1.000
259	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), AMT(1), FTCD(2), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2), TYMS(1)	5631919	13	12	13	3	5	2	2	0	4	0	0.428	0.999	1.000
260	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(1), CHAT(4), DDC(1), GAD1(3), GAD2(1), HDC(2), MAOA(2), TH(2), TPH1(2)	4159826	20	19	20	7	10	2	4	1	3	0	0.550	0.999	1.000
261	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(3), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(2), UGT2B4(4), UGT2B7(2)	7606465	22	20	22	7	7	4	3	1	7	0	0.801	0.999	1.000
262	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), SHMT1(1)	4451255	11	11	11	3	1	1	4	1	4	0	0.844	0.999	1.000
263	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), SHMT1(1)	4451255	11	11	11	3	1	1	4	1	4	0	0.844	0.999	1.000
264	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), SHMT1(1)	4451255	11	11	11	3	1	1	4	1	4	0	0.844	0.999	1.000
265	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(3), GNAS(7), GNB1(1), NFKB1(2), NOS3(2), NR3C1(2), PIK3CA(7), PIK3R1(2), RELA(1)	5359819	27	27	24	9	15	4	3	1	4	0	0.654	0.999	1.000
266	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	12	APC(5), CREBBP(6), DVL1(1), EP300(3), FZD1(1), GSK3B(2), LDB1(1), LEF1(2), TRRAP(4), WNT1(2)	8746181	27	25	27	5	13	2	5	1	6	0	0.0890	0.999	1.000
267	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), COASY(1), DPYD(3), ENPP3(1), PANK4(1), PPCS(1), UPB1(1)	4074560	10	10	10	3	7	2	1	0	0	0	0.520	0.999	1.000
268	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(1), ACO2(3), DLD(1), DLST(2), FH(2), IDH2(4), IDH3G(1), PC(4), PCK1(5), SDHA(3), SDHB(1), SUCLG1(2)	5814569	29	26	29	7	16	4	4	1	4	0	0.199	0.999	1.000
269	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), BDKRB2(3), NOS3(2)	2945175	7	6	7	3	3	1	1	1	1	0	0.732	0.999	1.000
270	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), CD38(2), ENPP3(1), NADSYN1(1)	4300366	8	7	8	2	5	0	1	2	0	0	0.542	0.999	1.000
271	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(1), F2(1), FGA(6), SERPINB2(1), SERPINE1(1)	3933839	12	12	12	4	7	2	1	0	2	0	0.573	0.999	1.000
272	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(7), CHEK1(1), MYT1(4), WEE1(2), YWHAH(1)	4419542	15	14	15	4	4	3	4	2	2	0	0.601	0.999	1.000
273	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), B3GAT2(1), B3GAT3(1), CHPF(4), CHST11(1), CHST12(1), CHST13(1), CHST3(3), CHST7(1), CHSY1(1), DSE(5), UST(1)	4033660	21	19	21	7	6	7	5	1	2	0	0.581	0.999	1.000
274	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), FOS(2), JUN(1), MAP2K1(1), NGFR(1), PIK3CA(7), PIK3R1(2), PLCG1(3), RAF1(1), SHC1(2), SOS1(4)	5603454	25	24	24	6	15	2	3	1	4	0	0.302	0.999	1.000
275	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(4), MAP2(4), PPP1CA(2), PPP2CA(1), PRKACB(1), PRKAR2B(1)	4928429	13	13	13	3	7	1	2	0	3	0	0.476	0.999	1.000
276	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), FOS(2), INSR(6), JUN(1), MAP2K1(1), PIK3CA(7), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(4), SHC1(2), SLC2A4(1), SOS1(4)	7470481	33	29	32	7	18	4	3	2	6	0	0.156	0.999	1.000
277	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(2), BIRC2(1), BIRC3(1), CASP8(1), CFLAR(1), FADD(2), JUN(1), MAP2K4(3), MAP3K7(1), NFKB1(2), NFKBIA(2), NFKBIB(1), NR2C2(1), RALBP1(1), RIPK1(2), TNF(2), TNFRSF1A(1)	8294071	25	25	25	7	10	4	2	1	8	0	0.553	0.999	1.000
278	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(1), CRY1(3), CSNK1E(2), NPAS2(4), NR1D1(1), PER1(2), PER2(4), PER3(1)	5015120	19	18	19	5	9	1	4	1	4	0	0.393	1.000	1.000
279	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADS(1), ACADVL(1), ACSL1(1), CPT1A(3), EHHADH(9), PECR(2)	4912783	18	11	18	7	7	5	2	1	3	0	0.795	1.000	1.000
280	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GLB1(2), GUSB(3), HEXA(1), IDUA(2), LCT(4), NAGLU(1)	4270926	13	12	13	7	7	1	3	0	2	0	0.820	1.000	1.000
281	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(6), CR2(5), ICAM1(1), ITGAL(3), ITGB2(2), PTPRC(4)	5004576	22	22	22	7	11	2	6	0	3	0	0.525	1.000	1.000
282	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACPP(4), ACPT(1), ALPI(1), ALPP(2), ALPPL2(1), CMBL(1), CYP3A4(1), CYP3A43(1), CYP3A5(3), CYP3A7(1), DHRS3(1), DHRS7(1), PON3(1)	5417451	20	19	20	7	7	2	4	3	4	0	0.761	1.000	1.000
283	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(1), HK2(4), HK3(3), IMPA1(1), PGM3(2)	3089987	11	10	11	6	6	2	0	2	1	0	0.819	1.000	1.000
284	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	FYN(1), LRP8(3), RELN(5), VLDLR(1)	4098742	10	10	10	9	3	1	3	1	2	0	0.991	1.000	1.000
285	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	BCL2(1), EGFR(4), IGF1R(6), MYC(1), POLR2A(5), PPP2CA(1), PRKCA(1), TEP1(5), TERF1(4), TNKS(3), XRCC5(1)	7326653	32	27	32	8	12	2	10	1	7	0	0.365	1.000	1.000
286	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDPS(1), HMGCR(4), LSS(1), MVK(1), PMVK(2), SQLE(1)	3266679	10	8	10	4	2	3	1	2	2	0	0.863	1.000	1.000
287	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(3), AKT3(1), BCL2(1), GSK3B(2), IL4R(1), IRS2(1), JAK1(2), JAK3(3), MAP4K1(1), MAPK1(1), PIK3CA(7), PIK3CD(4), PIK3R1(2), PPP1R13B(5), RAF1(1), SHC1(2), SOS1(4), SOS2(2), STAT6(1)	10644364	44	40	43	9	26	4	3	4	7	0	0.0697	1.000	1.000
288	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ANPEP(2), CTSG(1), ENPEP(1), LNPEP(4), MME(5), THOP1(1)	6193306	16	13	16	5	5	1	2	3	5	0	0.638	1.000	1.000
289	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ICAM1(1), ITGAL(3), ITGAM(1), ITGB2(2), SELE(1), SELL(1)	3161303	10	8	10	4	6	2	1	0	1	0	0.658	1.000	1.000
290	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(3), CA1(1), CA12(1), CA4(2), CA6(1), CA8(1), CA9(2), CPS1(6), CTH(1), GLS(1), GLUD1(2), GLUL(1)	5517736	23	22	23	9	11	2	4	2	4	0	0.745	1.000	1.000
291	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), CAMP(1), CREB5(1), MAPK1(1), RAF1(1), SNX13(2), SRC(1)	3399579	8	8	8	3	3	1	3	0	1	0	0.797	1.000	1.000
292	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ECHS1(1), EHHADH(9), SDS(2)	3573992	15	10	15	5	6	4	3	1	1	0	0.622	1.000	1.000
293	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), FOS(2), IL2RB(3), JAK1(2), JAK3(3), JUN(1), LCK(3), MAP2K1(1), RAF1(1), SHC1(2), SOS1(4), STAT5A(2), STAT5B(1), SYK(1)	7068414	27	23	27	5	15	3	5	2	2	0	0.133	1.000	1.000
294	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(1), GFPT1(1), GNE(1), HEXA(1), HK1(1), HK2(4), HK3(3), PGM3(2)	5054845	15	13	15	7	7	2	1	2	3	0	0.771	1.000	1.000
295	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(2), COPS5(1), EDN1(2), EP300(3), HIF1A(1), JUN(1), LDHA(1), NOS3(2), P4HB(1)	4987132	14	13	14	4	7	0	5	1	1	0	0.503	1.000	1.000
296	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	CCNE1(1), E2F1(1), MAPK1(1), NFKB1(2), NFKBIA(2), PAK1(1), PIK3CA(7), PIK3R1(2), RAF1(1), RELA(1), TFDP1(1)	5359300	20	20	19	5	11	2	4	0	3	0	0.416	1.000	1.000
297	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH1B(2), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(1), AOX1(4), DCT(1), DDC(1), GSTZ1(1), HGD(1), HPD(2), MAOA(2), MAOB(2), TH(2), TPO(9), TYR(4)	9312601	38	35	38	8	17	6	9	1	5	0	0.136	1.000	1.000
298	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), DPAGT1(1), FUT8(1), MAN1A1(1), MGAT1(1), MGAT2(1), MGAT3(2), MGAT5(2)	5881360	15	15	15	7	7	3	1	0	4	0	0.749	1.000	1.000
299	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(5), ASAH1(1), CAMP(1), CREB5(1), EPHB2(4), FOS(2), ITPKB(1), JUN(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8IP3(1), MAPK9(1)	8340844	25	22	25	7	10	2	5	1	7	0	0.581	1.000	1.000
300	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(1), CAPNS1(1), CXCR3(1), EGF(4), EGFR(4), ITGA1(3), ITGB1(1), MAPK1(1), PRKACB(1), PRKAR2B(1), PTK2(6), PXN(1), TLN1(3)	9870847	28	27	28	5	11	2	8	1	6	0	0.182	1.000	1.000
301	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT2(3), AKT3(1), BRD4(4), CBL(1), CDC42(2), CDKN2A(1), FLOT1(2), FLOT2(1), GSK3B(2), INPPL1(3), IRS2(1), IRS4(5), LNPEP(4), MAPK1(1), PARD3(4), PIK3CA(7), PIK3CD(4), PIK3R1(2), RAF1(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KB1(1), SERPINB6(2), SHC1(2), SLC2A4(1), SORBS1(2), SOS1(4), SOS2(2), YWHAE(2), YWHAH(1), YWHAZ(1)	16916734	77	66	76	12	39	11	11	4	12	0	0.00249	1.000	1.000
302	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(6), EP300(3), NCOA3(6), PRKACB(1), PRKAR2B(1), RARA(1), RXRA(5)	6067310	23	19	23	5	11	2	5	2	3	0	0.271	1.000	1.000
303	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(1), HK2(4), HK3(3), IMPA1(1), IMPA2(2), PGM3(2)	3494066	13	12	13	7	6	4	0	2	1	0	0.845	1.000	1.000
304	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CXCR4(1), GNAI1(2), GNB1(1), MAP2K1(1), MAPK1(1), NFKB1(2), PIK3C2G(5), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), PTK2(6), PTK2B(4), PXN(1), RAF1(1), RELA(1)	8303257	41	38	40	9	24	6	5	1	5	0	0.134	1.000	1.000
305	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	BAIAP2(1), CASP8(1), INSR(6), MAGI1(1), MAGI2(5), WWP2(2)	6903469	16	15	16	7	5	3	1	2	5	0	0.806	1.000	1.000
306	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(7), GNB1(1), PPP2CA(1), PRKAA1(3), PRKAB2(1), PRKACB(1), PRKAG2(1), PRKAR2B(1)	4544761	19	18	17	6	10	4	3	0	2	0	0.598	1.000	1.000
307	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), FOS(2), JAK2(4), JUN(1), MAP2K1(1), PLCG1(3), PTPN6(1), RAF1(1), SHC1(2), SOS1(4), STAT5A(2), STAT5B(1)	6470624	23	21	23	5	14	1	2	2	4	0	0.286	1.000	1.000
308	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), AMT(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2), TYMS(1)	5256640	11	10	11	3	5	2	2	0	2	0	0.428	1.000	1.000
309	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), FOS(2), IGF1R(6), JUN(1), MAP2K1(1), PIK3CA(7), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(4), SHC1(2), SOS1(4)	7259161	32	29	31	8	19	2	4	2	5	0	0.263	1.000	1.000
310	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	DUSP1(1), GORASP1(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK14(2), MAPK8IP3(1), MAPK9(1), MAPKAPK5(2), NFKB1(2), NFKBIA(2), NFKBIB(1), PIK3CA(7), PIK3CD(4), PIK3R1(2), TRAF5(1), TRAF6(1)	10445897	35	33	34	7	19	3	4	2	7	0	0.138	1.000	1.000
311	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(3), CCNB1(1), GNAI1(2), GNAS(7), GNB1(1), MAPK1(1), MYT1(4), PIN1(1), PRKACB(1), PRKAR2B(1), RPS6KA1(1), SRC(1)	6074458	24	23	22	5	10	7	5	0	2	0	0.271	1.000	1.000
312	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ICAM1(1), ITGA4(2), ITGAL(3), ITGB1(1), ITGB2(2), SELE(1), SELL(1)	3604557	12	11	12	5	6	2	1	2	1	0	0.740	1.000	1.000
313	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), JAK1(2), STAT1(2), STAT2(1), TYK2(2)	3673005	9	9	9	5	3	0	3	2	1	0	0.932	1.000	1.000
314	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD5(1), IFNB1(1), IFNG(2), IL12A(5), IL12B(1), IL4(1), ITGAX(1), TLR2(1), TLR4(2), TLR7(2), TLR9(2)	5456072	21	19	21	5	6	2	7	3	3	0	0.351	1.000	1.000
315	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(6), EP300(3), FYN(1), IL7(1), IL7R(1), JAK1(2), JAK3(3), LCK(3), NMI(2), PIK3CA(7), PIK3R1(2), PTK2B(4), STAT5A(2), STAT5B(1)	8281872	39	35	38	9	18	6	7	2	6	0	0.190	1.000	1.000
316	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(1), APC(5), BMP2(1), BMP5(3), BMP7(2), BMPR1A(1), BMPR2(3), CHRD(1), DVL1(1), FZD1(1), GSK3B(2), MAP3K7(1), MEF2C(1), NOG(1), RFC1(3), TGFB2(2), TGFB3(2), TGFBR1(1), WNT1(2)	9779200	34	30	34	7	17	4	6	1	6	0	0.0904	1.000	1.000
317	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(3), ASRGL1(1), CA1(1), CA12(1), CA4(2), CA6(1), CA8(1), CA9(2), CPS1(6), CTH(1), GLS(1), GLUD1(2), GLUD2(3), GLUL(1)	6163092	27	26	27	9	14	2	5	2	4	0	0.566	1.000	1.000
318	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(1), BLNK(2), FOS(2), JUN(1), LYN(1), MAP2K1(1), MAP3K1(2), MAPK1(1), MAPK8IP3(1), PAPPA(3), RPS6KA1(1), RPS6KA3(6), SHC1(2), SOS1(4), SYK(1), VAV1(3), VAV2(1), VAV3(4)	9430943	37	34	37	7	19	5	8	2	3	0	0.0809	1.000	1.000
319	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDPS(1), HMGCR(4), HMGCS1(2), LSS(1), MVK(1), NSDHL(1), PMVK(2), SQLE(1)	3902562	13	11	13	4	4	4	1	2	2	0	0.690	1.000	1.000
320	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), GOSR2(2), SNAP29(1), STX10(1), STX12(1), STX16(1), STX19(2), STX2(1), STX6(1), TSNARE1(1), USE1(1), VAMP1(1), VAMP3(1)	4998913	15	15	15	7	6	1	4	2	2	0	0.849	1.000	1.000
321	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(8), C5(3), C6(1), C7(1), ICAM1(1), IL6(2), ITGA4(2), ITGAL(3), ITGB1(1), ITGB2(2), SELP(1), TNF(2), VCAM1(1)	7291166	28	25	28	9	12	1	7	3	5	0	0.607	1.000	1.000
322	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(3), ACTN2(2), BCAR1(2), BCR(1), CAPN1(1), CAPNS1(1), CAV1(1), FYN(1), ITGA1(3), ITGB1(1), JUN(1), MAP2K1(1), MAP2K2(2), MAPK1(1), PPP1R12B(1), PTK2(6), PXN(1), RAF1(1), RAP1A(1), ROCK1(3), SHC1(2), SOS1(4), SRC(1), TLN1(3), VCL(3), ZYX(1)	13975262	48	35	48	8	23	9	7	4	5	0	0.0383	1.000	1.000
323	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	BAG4(2), CASP8(1), CRADD(1), DFFB(1), FADD(2), JUN(1), LMNA(2), LMNB1(1), LMNB2(2), MADD(2), MAP2K4(3), MAP3K1(2), MAP3K7(1), PAK1(1), PRKDC(11), RIPK1(2), SPTAN1(4), TNF(2), TNFRSF1A(1)	11235182	42	40	41	8	16	8	5	3	10	0	0.140	1.000	1.000
324	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(3), AKT3(1), CISH(2), IARS(1), IL13RA1(2), IL4(1), IL4R(1), JAK1(2), JAK2(4), JAK3(3), NR0B2(2), PIK3CA(7), PPP1R13B(5), RPS6KB1(1), SHC1(2), SOS1(4), SOS2(2), SRC(1), STAT6(1), TYK2(2)	10833832	47	42	46	9	27	5	6	4	5	0	0.0623	1.000	1.000
325	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSD(1), ASAH1(1), GALC(3), GLA(1), GLB1(2), LCT(4), NEU1(3), NEU2(3), NEU3(2), PPAP2A(3), PPAP2C(3), SMPD2(2), SPTLC2(2)	7109705	31	28	31	7	18	2	7	0	4	0	0.151	1.000	1.000
326	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(2), BECN1(1), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), IFNG(2), PIK3R4(2), PRKAA1(3), ULK1(2), ULK2(6)	6339728	31	26	31	7	12	5	7	4	3	0	0.253	1.000	1.000
327	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	MAP2K1(1), MAP2K2(2), MAP3K1(2), MAPK1(1), MAPK14(2), NFKB1(2), PIK3CA(7), PIK3R1(2), RELA(1), SP1(2)	5291102	22	20	21	7	16	2	2	0	2	0	0.436	1.000	1.000
328	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC2(2), ABCG2(2), BCHE(1), CES1(1), CES2(1), CYP3A4(1), CYP3A5(3), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A9(1)	6761514	17	16	17	5	9	1	2	1	4	0	0.460	1.000	1.000
329	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2A1(2), AP2M1(1), BIN1(2), EPS15(1), NME1(1), PPP3CA(4), SYNJ1(2), SYNJ2(1)	6673355	18	16	18	6	8	4	1	1	4	0	0.517	1.000	1.000
330	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(3), CPT1A(3), LEP(1), LEPR(3), PRKAA1(3), PRKAB2(1), PRKAG2(1)	4223612	15	15	15	9	9	1	3	1	1	0	0.898	1.000	1.000
331	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), IFNB1(1), IFNG(2), IL12A(5), IL12B(1), IL4(1), IL6(2), IL7(1), LTA(1), PDGFA(1), TGFB2(2), TGFB3(2), TNF(2)	4038854	22	22	22	6	8	3	9	1	1	0	0.437	1.000	1.000
332	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	16	NFATC2(3), NFATC3(1), NFATC4(4), PLCG1(3), PPP3CA(4), PRKCA(1), SP1(2), SP3(3)	5811977	21	18	21	5	14	1	2	2	2	0	0.271	1.000	1.000
333	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	CASP6(1), CASP8(1), CFLAR(1), DFFB(1), FADD(2), FAF1(2), JUN(1), LMNA(2), LMNB1(1), LMNB2(2), MAP2K4(3), MAP3K1(2), MAP3K7(1), PAK1(1), PRKDC(11), PTPN13(11), RIPK2(1), SPTAN1(4)	12171359	48	43	47	9	20	10	6	2	10	0	0.100	1.000	1.000
334	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B4GALT2(1), B4GALT3(2), FUT1(2), FUT3(1), FUT9(2), ST3GAL6(1), ST8SIA1(1)	4602203	11	9	11	5	1	2	5	1	2	0	0.932	1.000	1.000
335	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACAT2(4), DHRS3(1), DHRS7(1), ECHS1(1), EHHADH(9), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(1)	7544037	23	18	23	5	10	4	6	1	2	0	0.220	1.000	1.000
336	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), AOC2(2), AOC3(1), DPYD(3), ECHS1(1), EHHADH(9), GAD1(3), GAD2(1), HIBCH(4), SRM(2), UPB1(1)	7844069	31	26	31	7	14	6	5	4	2	0	0.185	1.000	1.000
337	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GLB1(2), GUSB(3), HEXA(1), HGSNAT(2), HPSE(1), HPSE2(1), HYAL1(1), IDUA(2), LCT(4), NAGLU(1), SPAM1(3)	6156795	21	20	21	9	10	3	5	0	3	0	0.750	1.000	1.000
338	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT2(3), AKT3(1), BCR(1), BTK(1), CD19(1), CDKN2A(1), DAPP1(1), FLOT1(2), FLOT2(1), GAB1(3), ITPR1(6), ITPR2(3), ITPR3(8), LYN(1), NR0B2(2), PHF11(1), PIK3CA(7), PLCG2(5), PPP1R13B(5), PREX1(8), PTPRC(4), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KB1(1), SAG(1), SYK(1), VAV1(3)	16112332	81	66	80	12	42	17	13	2	7	0	0.00120	1.000	1.000
339	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	EGFR(4), JUN(1), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K1(2), MAPK1(1), MEF2A(3), MEF2C(1), MEF2D(1), PAK1(1), PRKCA(1), PTK2(6), PTK2B(4), RAF1(1), SHC1(2), SOS1(4), SRC(1)	10070090	39	36	39	8	20	3	9	1	6	0	0.153	1.000	1.000
340	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1D1(2), ARSD(1), CYP11B1(1), CYP11B2(5), HSD17B3(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A9(1), UGT2B15(1), UGT2B4(4)	8003615	21	21	21	7	11	2	2	1	5	0	0.647	1.000	1.000
341	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACPP(4), ACPT(1), ENPP3(1), FLAD1(3), LHPP(1), MTMR1(1), MTMR6(2), TYR(4)	4458857	18	16	18	7	8	2	5	2	1	0	0.765	1.000	1.000
342	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(2), EPHB1(3), FYN(1), ITGA1(3), ITGB1(1), L1CAM(4), LYN(1), SELP(1)	4626865	16	16	16	6	6	3	3	3	1	0	0.744	1.000	1.000
343	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD4(1), CREBBP(6), GNAS(7), GNB1(1), LCK(3), PRKACB(1), PRKAR2B(1), PTPRC(4), ZAP70(1)	6763993	28	24	26	6	12	6	7	0	3	0	0.280	1.000	1.000
344	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD4(1), CREBBP(6), GNAS(7), GNB1(1), LCK(3), PRKACB(1), PRKAR2B(1), PTPRC(4), ZAP70(1)	6763993	28	24	26	6	12	6	7	0	3	0	0.280	1.000	1.000
345	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR24(1), FDPS(1), GGPS1(1), HMGCR(4), LSS(1), MVK(1), NSDHL(1), PMVK(2), SQLE(1)	5733388	13	10	13	5	4	3	1	2	3	0	0.767	1.000	1.000
346	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(1), ALDH18A1(1), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), AOC2(2), AOC3(1), ARG1(2), ASS1(2), CPS1(6), GATM(1), MAOA(2), MAOB(2), NAGS(1), ODC1(1), SRM(2)	8669754	27	24	27	6	10	7	5	1	4	0	0.286	1.000	1.000
347	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(1), EPX(2), ESCO1(2), ESCO2(2), HPD(2), LPO(3), MAOA(2), MAOB(2), MPO(5), PNPLA3(1), SH3GLB1(1), TPO(9)	9957420	37	31	37	8	16	6	8	0	7	0	0.138	1.000	1.000
348	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), GLB1(2), HEXA(1), LCT(4), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(2), ST8SIA1(1)	4787287	16	15	16	5	11	0	4	0	1	0	0.425	1.000	1.000
349	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(1), ASAH1(1), B4GALT6(2), DEGS1(2), GALC(3), GLA(1), GLB1(2), LCT(4), NEU1(3), NEU2(3), NEU3(2), PPAP2A(3), PPAP2C(3), SGPP1(1), SGPP2(1), SMPD2(2), SMPD4(2), SPHK1(2), SPHK2(1), SPTLC2(2), UGT8(1)	10461594	43	38	43	9	26	3	9	0	5	0	0.0618	1.000	1.000
350	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), AOC2(2), AOC3(1), CES1(1), DDHD1(2), ESCO1(2), ESCO2(2), LIPA(2), PNPLA3(1), SH3GLB1(1)	7432758	17	14	17	6	4	4	5	0	4	0	0.640	1.000	1.000
351	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(2), IFNG(2), IKBKB(3), IL4(1), JUN(1), MAP3K1(2), MAP3K5(2), MAP4K5(3), MAPK14(2), NFKB1(2), NFKBIA(2), RELA(1)	5819879	23	22	23	7	12	3	6	0	2	0	0.508	1.000	1.000
352	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(5), ATM(7), CPB2(2), HIF1A(1), IGFBP3(1), MDM2(1), NFKBIB(1)	5978042	18	16	18	5	5	2	5	3	3	0	0.622	1.000	1.000
353	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ADH1A(2), ADH1B(2), ADH5(1), DHRS3(1), DHRS7(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(1)	7252042	15	15	15	4	6	3	2	0	4	0	0.486	1.000	1.000
354	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA4(2), PSMA7(3), PSMB5(2), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(6), PSMD13(2), PSMD2(1)	4729783	20	17	20	5	9	5	5	1	0	0	0.346	1.000	1.000
355	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ICAM1(1), ITGA4(2), ITGAL(3), ITGAM(1), ITGB1(1), ITGB2(2), SELE(1), SELL(1), SELP(1)	4797194	14	11	14	6	7	2	2	2	1	0	0.749	1.000	1.000
356	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(6), EP300(3), LPL(1), NCOA1(2), NCOA2(4), RXRA(5)	5375278	21	19	21	6	11	3	4	1	2	0	0.415	1.000	1.000
357	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK2A(3), CAMK2B(1), ESRRA(1), MEF2A(3), MEF2C(1), MEF2D(1), PPARA(2), PPP3CA(4), SLC2A4(1), YWHAH(1)	6245869	18	17	18	5	6	6	1	2	3	0	0.416	1.000	1.000
358	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(2), FYN(1), GSN(1), ITGA1(3), ITGB1(1), MAP2K1(1), MAPK1(1), PIK3CA(7), PIK3R1(2), PTK2(6), PXN(1), RAF1(1), ROCK1(3), SHC1(2), SRC(1), TLN1(3)	11101529	36	33	35	7	16	4	5	4	7	0	0.158	1.000	1.000
359	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	CREB5(1), DUSP6(3), DUSP9(1), EEF2K(1), MAP2K1(1), MAP2K2(2), MAPK1(1), MKNK1(1), MKNK2(1), MOS(1), NFKB1(2), RAP1A(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), SHC1(2), SOS1(4), SOS2(2)	8785471	34	28	34	7	22	4	4	1	3	0	0.0727	1.000	1.000
360	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), GLCE(1), HS2ST1(2), NDST1(1), NDST2(2), NDST3(1), NDST4(6)	6152795	18	15	18	9	9	2	3	2	2	0	0.840	1.000	1.000
361	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1L(1), GTF2B(2), GTF2E1(1), GTF2IRD1(1), STON1(3), TAF1(6), TAF1L(3), TAF2(2), TAF4B(2), TAF5(1), TAF6L(1), TAF7L(1), TAF9B(1), TBPL1(2)	10975808	27	24	27	6	14	1	4	0	7	1	0.284	1.000	1.000
362	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(2), FPGT(2), GMPPA(3), HK1(1), HK2(4), HK3(3), MPI(1), PFKFB1(3), PFKFB3(2), PFKP(2), PMM1(1), SORD(1)	7146160	25	23	25	7	14	6	0	2	3	0	0.304	1.000	1.000
363	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), GPT(1), ME2(1), ME3(1)	5319012	5	5	5	4	1	1	2	0	1	0	0.969	1.000	1.000
364	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	APAF1(3), ATM(7), BCL2(1), CASP6(1), PRKCA(1), PTK2(6), PXN(1), STAT1(2), TLN1(3)	7728642	25	25	25	6	10	3	7	1	4	0	0.353	1.000	1.000
365	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(4), ADRBK2(1), ARRB2(1), CAMK2A(3), CAMK2B(1), CLCA1(3), CLCA2(4), CLCA4(1), CNGA3(6), CNGA4(2), CNGB1(1), GNAL(2), GUCA1B(1), PDE1C(5), PRKACA(1), PRKACB(1), PRKG1(3), PRKX(2)	9157508	42	32	42	9	19	13	5	0	5	0	0.156	1.000	1.000
366	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNB1(1), IKBKB(3), IL1B(1), IL1R1(3), IL6(2), IRAK1(2), IRAK3(3), JUN(1), MAP3K1(2), MAP3K7(1), MAPK14(2), MYD88(1), NFKB1(2), NFKBIA(2), RELA(1), TGFB2(2), TGFB3(2), TNF(2), TRAF6(1)	8737181	36	33	36	8	18	4	10	1	3	0	0.182	1.000	1.000
367	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AP2A1(2), AP2M1(1), BTK(1), EEA1(2), GSK3B(2), LYN(1), PFKL(1), PFKP(2), PLCG1(3), PRKCZ(1), RPS6KB1(1), VAV2(1)	7236747	18	17	18	8	8	3	2	2	3	0	0.797	1.000	1.000
368	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(1), COASY(1), DPYD(3), ENPP3(1), PANK4(1), PPCS(1), UPB1(1)	5074800	11	11	11	4	7	2	2	0	0	0	0.658	1.000	1.000
369	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(2), GSTA2(1), GSTA4(1), GSTO2(1), GSTP1(2), GSTZ1(1), IDH2(4), PGD(1)	5422308	13	12	13	5	5	2	3	2	1	0	0.724	1.000	1.000
370	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1QA(2), C1S(1), C2(1), C3(8), C4B(1), C5(3), C6(1), C7(1), C9(2)	9191871	20	18	20	8	7	2	3	3	5	0	0.825	1.000	1.000
371	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(2), FADD(2), IKBKB(3), IL1R1(3), IRAK1(2), MAP3K1(2), MAP3K7(1), MYD88(1), NFKB1(2), NFKBIA(2), RELA(1), RIPK1(2), TLR4(2), TNF(2), TNFRSF1A(1), TRAF6(1)	7381095	29	28	29	7	16	5	7	0	1	0	0.260	1.000	1.000
372	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(1), IARS2(2), PDHA1(1), PDHA2(3), PDHB(1)	5465959	11	11	11	6	6	2	2	0	1	0	0.888	1.000	1.000
373	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(2), DUSP1(1), IKBKAP(2), IKBKB(3), MAP3K1(2), NFKB1(2), NFKBIA(2), RELA(1), TRAF6(1)	5614978	16	16	16	6	8	2	4	1	1	0	0.708	1.000	1.000
374	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAD8(2), ADH1A(2), ADH1B(2), ADH5(1), AKR1D1(2), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), BAAT(1), CEL(1), CYP27A1(3), CYP7A1(1), HADHB(1), HSD3B7(1), LIPA(2), RDH12(1), RDH13(1), RDH14(1), SOAT2(1)	9363823	27	25	27	8	14	6	2	0	5	0	0.378	1.000	1.000
375	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ATM(7), BRCA1(4), CHEK1(1), CHEK2(2), JUN(1), MDM2(1), NFKB1(2), NFKBIA(2), RAD50(1), RAD51(3), RBBP8(2), RELA(1), TP73(1)	8319123	28	23	28	7	11	3	7	3	4	0	0.472	1.000	1.000
376	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), GPT(1), ME3(1), PGK2(2), TKTL1(2), TKTL2(3)	5936993	11	11	11	4	3	3	4	0	1	0	0.739	1.000	1.000
377	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPNS1(1), EP300(3), HDAC2(1), MEF2D(1), NFATC2(3), PPP3CA(4), PRKCA(1)	7052228	19	17	19	5	11	0	5	1	2	0	0.295	1.000	1.000
378	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), CAD(2), CPS1(6), EPRS(3), GAD1(3), GAD2(1), GFPT1(1), GLS(1), GLUD1(2), GLUL(1), GMPS(2), GPT(1), NADSYN1(1), PPAT(1)	9793942	26	22	26	9	11	4	3	2	6	0	0.590	1.000	1.000
379	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ATM(7), ATR(6), CCNA1(1), CCNE1(1), CDKN2A(1), E2F1(1), GSK3B(2), SKP2(1), TFDP1(1), TGFB2(2), TGFB3(2)	7928902	25	23	25	7	7	3	10	2	3	0	0.598	1.000	1.000
380	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ADH1A(2), ADH1B(2), AKR1D1(2), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), BAAT(1), CEL(1), CYP27A1(3), CYP7A1(1), HADHB(1), SOAT2(1)	6810986	18	18	18	5	10	5	1	0	2	0	0.390	1.000	1.000
381	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(1), HARS(1), HDC(2), MAOA(2), MAOB(2), PRPS2(1)	7180267	16	12	16	6	5	3	6	0	2	0	0.695	1.000	1.000
382	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(2), CD36(1), CITED2(1), CPT1B(3), CREBBP(6), DUSP1(1), EHHADH(9), EP300(3), FABP1(1), JUN(1), LPL(1), MAPK1(1), MRPL11(1), MYC(1), NCOA1(2), NCOR1(2), NCOR2(6), NFKBIA(2), NR0B2(2), NR1H3(2), PDGFA(1), PIK3CA(7), PIK3R1(2), PPARA(2), PRKACB(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RELA(1), RXRA(5), SP1(2), STAT5A(2), STAT5B(1), TNF(2)	18316495	77	58	76	12	37	10	11	6	13	0	0.0112	1.000	1.000
383	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1QA(2), C1S(1), C2(1), C3(8), C4B(1), C5(3), C6(1), C7(1), C8B(1), C9(2)	10153955	21	19	21	9	8	2	3	3	5	0	0.851	1.000	1.000
384	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(4), BST1(1), CD38(2), ENPP3(1), NADSYN1(1), NMNAT3(1), NT5C1B(1), NT5C2(1), NUDT12(1)	6328678	13	12	13	5	8	0	2	2	1	0	0.641	1.000	1.000
385	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	CAMK2A(3), CAMK2B(1), F2(1), FYN(1), GNAI1(2), GNB1(1), JAK2(4), MAP2K1(1), MAP2K2(2), MAPK1(1), MAPK14(2), MAPT(3), PLCG1(3), PRKCA(1), PTK2B(4), RAF1(1), SHC1(2), SOS1(4), STAT1(2), STAT3(3), STAT5A(2)	12530357	44	38	44	9	25	2	7	3	7	0	0.0765	1.000	1.000
386	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CFL1(1), MAP3K1(2), NCF2(1), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(2), PLD1(2), PPP1R12B(1), RALBP1(1), RPS6KB1(1), TRIO(2), VAV1(3)	10324424	28	27	27	9	12	4	5	2	5	0	0.504	1.000	1.000
387	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	COL4A1(3), COL4A2(4), COL4A4(6), COL4A5(3), COL4A6(4)	7580532	20	17	20	9	8	4	3	2	3	0	0.855	1.000	1.000
388	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(3), COL4A2(4), COL4A4(6), COL4A5(3), COL4A6(4), P4HB(1), SLC23A2(2), SLC2A3(1)	7614741	24	19	24	9	10	5	4	2	3	0	0.735	1.000	1.000
389	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1B1(1), ALDH3A1(1), ALDH3B2(1), ALDH7A1(1), AMDHD1(1), AOC2(2), AOC3(1), DDC(1), FTCD(2), HARS(1), HARS2(1), HDC(2), HEMK1(2), LCMT1(1), LCMT2(3), MAOA(2), MAOB(2), METTL2B(3), METTL6(1), PRMT6(2), PRMT7(1), PRMT8(1), PRPS2(1), UROC1(2), WBSCR22(1)	11669126	38	27	38	8	17	6	8	1	6	0	0.166	1.000	1.000
390	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADL(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), AOC2(2), AOC3(1), DPYD(3), ECHS1(1), EHHADH(9), GAD1(3), GAD2(1), SDS(2), UPB1(1)	8434888	28	23	28	9	13	6	5	2	2	0	0.545	1.000	1.000
391	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(2), GSR(2), GSTA2(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTP1(2), GSTZ1(1), IDH2(4), OPLAH(3)	6656036	18	15	18	7	8	4	3	2	1	0	0.696	1.000	1.000
392	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(2), DUSP1(1), IKBKAP(2), IKBKB(3), LTA(1), MAP3K1(2), NFKB1(2), NFKBIA(2), RELA(1), RIPK1(2), TRAF1(1)	6834268	19	19	19	5	10	2	5	1	1	0	0.418	1.000	1.000
393	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(1), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), NFAT5(4), PDE6A(3), PDE6B(3), SLC6A13(2), TF(1)	10740624	35	31	35	8	17	7	3	2	6	0	0.230	1.000	1.000
394	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B2(2), EIF2B5(1), EIF2S3(1), ELAVL1(3), FLT1(4), FLT4(6), HIF1A(1), KDR(9), NOS3(2), PIK3CA(7), PIK3R1(2), PLCG1(3), PRKCA(1), PTK2(6), PXN(1), SHC1(2)	10250255	51	46	50	10	21	8	8	3	11	0	0.109	1.000	1.000
395	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(3), DIAPH2(1), GMNN(1), MCM10(4), MCM2(3), MCM3(1), MCM4(1), MCM5(1), MCM7(3), NACA(2), POLA2(1), POLD1(2), POLE(3), POLE2(2), RFC1(3), RFC3(1), RFC4(1), RFC5(2), RPS27A(1), UBC(1)	15003830	37	31	37	7	15	8	8	3	3	0	0.121	1.000	1.000
396	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(7), EEF1A2(1), EEF1G(1), EEF2K(1), EIF2AK2(1), EIF2AK3(2), EIF2B2(2), EIF2B5(1), EIF2S3(1), EIF4A2(1), EIF4G1(4), EIF4G3(4), EIF5A(2), ETF1(1), PABPC1(1), PABPC3(2)	13048773	32	29	32	9	16	3	6	1	6	0	0.375	1.000	1.000
397	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	EPRS(3), GARS(1), HARS(1), IARS(1), MARS(3), MARS2(1), SARS(1), TARS(1)	9346326	12	10	12	6	4	3	1	1	3	0	0.828	1.000	1.000
398	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(2), FOS(2), IKBKB(3), IRAK1(2), JUN(1), LY96(1), MAP2K4(3), MAP3K1(2), MAP3K7(1), MAPK14(2), MYD88(1), NFKB1(2), NFKBIA(2), PPARA(2), RELA(1), TLR10(1), TLR2(1), TLR3(1), TLR4(2), TLR7(2), TLR9(2), TRAF6(1)	10958129	37	33	37	9	18	6	7	2	4	0	0.309	1.000	1.000
399	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(3), ACTN2(2), CAPN1(1), CAPNS1(1), ITGA1(3), ITGB1(1), PTK2(6), PXN(1), SPTAN1(4), SRC(1), TLN1(3)	8511117	26	22	26	7	11	8	4	1	2	0	0.434	1.000	1.000
400	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(7), ATR(6), BRCA1(4), BRCA2(6), CHEK1(1), CHEK2(2), FANCA(5), FANCD2(2), FANCE(1), FANCG(1), HUS1(1), RAD1(2), RAD50(1), RAD51(3), RAD9A(1), TREX1(1)	12630840	44	33	44	9	17	6	13	2	6	0	0.185	1.000	1.000
401	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(5), AR(2), ASAH1(1), CAMP(1), CCL13(1), CCL15(1), EGFR(4), GNA15(1), GNAI1(2), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), KCNJ3(1), MAPK1(1), MAPK10(3), MAPK14(2), PHKA2(2), PIK3CA(7), PIK3CD(4), PIK3R1(2), PTX3(1), RAF1(1), SRC(1)	15942728	61	50	60	11	33	8	10	2	8	0	0.0313	1.000	1.000
402	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(1), ARHGEF11(1), ARHGEF5(1), ARPC1A(1), ARPC1B(1), ARPC2(1), BAIAP2(1), CFL1(1), GSN(1), PIP5K1B(1), PPP1R12B(1), ROCK1(3), SRC(1), TLN1(3), VCL(3)	14113691	25	20	25	7	8	3	3	3	8	0	0.566	1.000	1.000
403	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(4), ADCY9(1), ARF5(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0D2(2), ATP6V1A(2), ATP6V1D(1), ATP6V1F(2), GNAS(7), PLCG1(3), PLCG2(5), PRKCA(1)	10962943	35	32	33	9	16	11	4	0	4	0	0.365	1.000	1.000
404	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), CYP2C9(1), DHRS3(1), DHRS7(1), ECHS1(1), EHHADH(9), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(1)	9013995	22	17	22	7	9	6	5	1	1	0	0.481	1.000	1.000
405	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP5(3), BMP7(2), BTRC(1), CSNK1A1L(3), CSNK1E(2), CSNK1G1(1), CSNK1G3(1), FBXW11(1), GLI1(1), GLI2(10), GLI3(6), GSK3B(2), HHIP(4), LRP2(12), PRKACA(1), PRKACB(1), PRKX(2), PTCH1(1), PTCH2(3), RAB23(1), STK36(1), SUFU(3), WNT1(2), WNT2(1), WNT3A(1), WNT4(1), WNT6(2), WNT8A(1), WNT8B(1), WNT9B(1)	17483490	73	60	73	14	34	14	14	2	9	0	0.0299	1.000	1.000
406	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	ASAH1(1), CAMP(1), CREB5(1), CREBBP(6), JUN(1), MAP1B(7), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8IP3(1), MAPK9(1), NTRK1(2), PIK3C2G(5), PIK3CA(7), PIK3CD(4), PIK3R1(2), PTPN11(1), RPS6KA3(6), SHC1(2), SRC(1), TH(2)	15426918	58	48	57	12	32	6	8	3	9	0	0.0596	1.000	1.000
407	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT2(3), AKT3(1), CDC42(2), CDKN2A(1), CREB5(1), ERBB4(4), GAB1(3), GSK3B(2), INPPL1(3), IRS2(1), IRS4(5), MYC(1), NOLC1(2), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PARD3(4), PIK3CA(7), PIK3CD(4), PPP1R13B(5), PREX1(8), PTK2(6), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KB1(1), SHC1(2), SLC2A4(1), SOS1(4), SOS2(2), TSC1(7), TSC2(9), YWHAE(2), YWHAH(1), YWHAZ(1)	22145240	117	79	116	22	56	18	17	6	20	0	0.00353	1.000	1.000
408	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(4), GNAS(7), GNB1(1), IGF1R(6), ITGB1(1), MAP2K1(1), MAP2K2(2), MAPK1(1), MKNK1(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(4), PPP2CA(1), PTPRR(1), RAF1(1), RPS6KA1(1), RPS6KA5(1), SHC1(2), SOS1(4), SRC(1), STAT3(3)	9878130	46	38	44	10	26	2	12	4	2	0	0.128	1.000	1.000
409	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT2(3), AKT3(1), CDC42(2), KDR(9), KRAS(4), MAP2K1(1), MAP2K2(2), MAPK1(1), MAPK14(2), MAPKAPK2(1), MAPKAPK3(1), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NOS3(2), NRAS(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLCG1(3), PLCG2(5), PPP3CA(4), PRKCA(1), PRKCG(1), PTGS2(1), PTK2(6), PXN(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), SPHK1(2), SPHK2(1), SRC(1)	21387138	107	80	106	21	56	16	14	2	19	0	0.00767	1.000	1.000
410	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(7), CCNA1(1), CCNB1(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(1), CDK7(1), CDKN2A(1), CREB3L1(2), CREB3L3(2), E2F1(1), E2F3(2), E2F6(2), MCM2(3), MCM3(1), MCM4(1), MCM5(1), MCM7(3), MDM2(1), MYC(1), MYT1(4), NACA(2), POLA2(1), POLE(3), POLE2(2), RBL1(3), TFDP1(1), TFDP2(1), TNXB(8), WEE1(2)	21959341	62	49	62	11	24	12	13	5	8	0	0.0326	1.000	1.000
411	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(1), ACOX1(2), ACOX2(3), ACOX3(1), ACSL1(1), ACSL5(1), ACSL6(1), APOC3(1), CD36(1), CPT1A(3), CPT1B(3), CPT1C(2), CYP27A1(3), CYP4A11(1), CYP4A22(2), CYP7A1(1), CYP8B1(2), EHHADH(9), FABP1(1), GK2(2), LPL(1), NR1H3(2), PCK1(5), PLTP(1), PPARA(2), PPARD(1), RXRA(5), RXRB(2), RXRG(1), SLC27A2(1), SLC27A6(3), SORBS1(2), UBC(1), UCP1(2)	19298555	71	52	71	15	36	10	11	5	9	0	0.0522	1.000	1.000
412	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), AOC2(2), AOC3(1), ARG1(2), CKB(1), CKMT1B(1), CKMT2(1), CPS1(6), DAO(5), GATM(1), GLUD1(2), MAOA(2), MAOB(2), NOS1(9), NOS3(2), OAT(2), ODC1(1), P4HA2(2), P4HA3(1), P4HB(1)	13280513	48	40	48	11	22	10	9	1	6	0	0.150	1.000	1.000
413	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(3), AKT3(1), BCL2(1), BCR(1), BLNK(2), BTK(1), CD19(1), CD22(3), CD81(1), CR2(5), FLOT1(2), FLOT2(1), GSK3B(2), ITPR1(6), ITPR2(3), ITPR3(8), LYN(1), MAP4K1(1), MAPK1(1), NFATC2(3), NR0B2(2), PIK3CA(7), PIK3CD(4), PIK3R1(2), PLCG2(5), PPP1R13B(5), PPP3CA(4), PTPRC(4), RAF1(1), SHC1(2), SOS1(4), SOS2(2), SYK(1), VAV1(3)	21644038	93	75	92	18	51	15	13	5	9	0	0.00966	1.000	1.000
414	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTG1(1), ACTN1(3), ACTN2(2), AKT2(3), AKT3(1), ARHGAP5(2), BCAR1(2), BCL2(1), BIRC2(1), BIRC3(1), CAV1(1), CAV2(1), CCND2(1), CDC42(2), COL11A1(10), COL11A2(1), COL1A1(1), COL1A2(3), COL2A1(4), COL3A1(3), COL4A1(3), COL4A2(4), COL4A4(6), COL4A6(4), COL5A1(6), COL5A2(7), COL5A3(3), COL6A1(1), COL6A2(3), COL6A3(10), COL6A6(13), DOCK1(6), EGF(4), EGFR(4), FARP2(2), FLNA(4), FLNB(5), FLNC(3), FLT1(4), FN1(7), FYN(1), GSK3B(2), HGF(5), IBSP(2), IGF1R(6), ITGA1(3), ITGA10(6), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAV(4), ITGB1(1), ITGB4(5), ITGB5(3), ITGB6(1), ITGB7(1), ITGB8(2), JUN(1), KDR(9), LAMA1(11), LAMA2(5), LAMA3(7), LAMA4(2), LAMA5(5), LAMB1(1), LAMB2(2), LAMB3(3), LAMB4(4), LAMC1(6), LAMC2(3), LAMC3(4), MAP2K1(1), MAPK1(1), MAPK10(3), MAPK9(1), MYLK2(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PDGFA(1), PDGFB(1), PDGFC(1), PDGFD(2), PDGFRA(4), PDGFRB(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PIP5K1C(1), PPP1CA(2), PPP1CC(1), PPP1R12A(3), PRKCA(1), PRKCG(1), PTK2(6), PXN(1), RAC2(1), RAF1(1), RAP1A(1), RAPGEF1(4), RELN(5), ROCK1(3), ROCK2(3), SHC1(2), SHC2(1), SHC4(3), SOS1(4), SOS2(2), SPP1(1), SRC(1), THBS1(3), THBS2(2), THBS3(3), THBS4(1), TLN1(3), TLN2(2), TNC(4), TNN(5), TNR(3), TNXB(8), VASP(1), VAV1(3), VAV2(1), VAV3(4), VCL(3), VEGFC(3), VTN(1), VWF(5), ZYX(1)	110553248	426	151	424	125	175	71	88	20	71	1	0.162	1.000	1.000
415	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(3), ADCY2(7), ADCY3(4), ADCY4(2), ADCY7(1), ADCY8(5), ADCY9(1), ADORA2A(1), ADORA2B(2), ADRA1A(1), ADRA1B(1), ADRA1D(3), ADRB2(3), ATP2A1(2), ATP2A3(1), ATP2B1(1), ATP2B2(4), ATP2B4(4), AVPR1B(1), BDKRB2(3), BST1(1), CACNA1A(6), CACNA1B(6), CACNA1C(5), CACNA1D(3), CACNA1E(18), CACNA1F(1), CACNA1G(1), CACNA1H(5), CACNA1I(2), CACNA1S(2), CAMK2A(3), CAMK2B(1), CCKBR(3), CD38(2), CHRM2(4), CHRM3(3), CHRM5(2), CHRNA7(1), CYSLTR1(1), CYSLTR2(1), EDNRA(3), EDNRB(1), EGFR(4), ERBB3(6), ERBB4(4), GNA15(1), GNAL(2), GNAS(7), GRIN1(3), GRIN2A(2), GRIN2D(1), GRM1(3), GRM5(3), HTR2C(4), HTR5A(1), HTR6(1), HTR7(5), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), LHCGR(4), MYLK2(1), NOS1(9), NOS3(2), OXTR(1), P2RX1(1), P2RX3(1), PDE1A(1), PDE1B(1), PDE1C(5), PDGFRA(4), PDGFRB(1), PHKA1(2), PHKA2(2), PHKB(5), PHKG2(3), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(4), PLCG1(3), PLCG2(5), PLCZ1(1), PPP3CA(4), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKX(2), PTGER3(2), PTK2B(4), RYR1(8), RYR2(25), RYR3(13), SLC25A5(1), SLC8A1(4), SLC8A2(1), SPHK1(2), SPHK2(1), TACR1(2), TACR2(2), TACR3(4), TNNC2(1), TRHR(4), TRPC1(2)	82069367	354	150	352	118	151	73	62	17	51	0	0.465	1.000	1.000
416	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(1), ACVR1C(1), AKT2(3), AKT3(1), ARRB1(1), ARRB2(1), BDNF(1), CACNA1A(6), CACNA1B(6), CACNA1C(5), CACNA1D(3), CACNA1E(18), CACNA1F(1), CACNA1G(1), CACNA1H(5), CACNA1I(2), CACNA1S(2), CACNA2D1(4), CACNA2D2(2), CACNA2D3(2), CACNA2D4(6), CACNB1(1), CACNB4(3), CACNG1(1), CACNG2(4), CACNG3(1), CACNG4(2), CACNG7(1), CDC42(2), CHUK(2), DDIT3(1), DUSP1(1), DUSP14(1), DUSP2(1), DUSP6(3), DUSP7(1), DUSP8(1), DUSP9(1), ECSIT(2), EGF(4), EGFR(4), ELK4(1), FASLG(1), FGF11(1), FGF13(1), FGF14(1), FGF20(1), FGF3(1), FGF6(2), FGFR2(3), FGFR3(1), FGFR4(1), FLNA(4), FLNB(5), FLNC(3), FOS(2), GNG12(1), IKBKB(3), IL1B(1), IL1R1(3), JUN(1), JUND(1), KRAS(4), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K1(2), MAP3K12(1), MAP3K2(1), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(1), MAPK1(1), MAPK10(3), MAPK14(2), MAPK7(4), MAPK8IP3(1), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAPT(3), MEF2C(1), MKNK1(1), MKNK2(1), MOS(1), MRAS(1), MYC(1), NF1(6), NFATC2(3), NFATC4(4), NFKB1(2), NLK(1), NR4A1(2), NRAS(1), NTRK1(2), NTRK2(2), PAK1(1), PDGFA(1), PDGFB(1), PDGFRA(4), PDGFRB(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PPM1B(1), PPP3CA(4), PPP5C(2), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKX(2), PTPN5(2), PTPRR(1), RAC2(1), RAF1(1), RAP1A(1), RAPGEF2(4), RASA1(4), RASGRF1(5), RASGRF2(3), RASGRP1(3), RASGRP2(2), RASGRP4(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA4(1), RPS6KA5(1), RPS6KA6(5), SOS1(4), SOS2(2), STK3(2), STK4(1), STMN1(1), TAOK1(1), TAOK2(1), TAOK3(2), TGFB2(2), TGFB3(2), TGFBR1(1), TNF(2), TNFRSF1A(1), TRAF6(1), ZAK(1)	87413662	326	148	326	94	151	48	62	14	51	0	0.0661	1.000	1.000
417	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(1), ADORA2A(1), ADORA2B(2), ADORA3(2), ADRA1A(1), ADRA1B(1), ADRB2(3), AVPR1B(1), BDKRB2(3), C3AR1(1), CALCR(1), CCKBR(3), CHRM2(4), CHRM3(3), CHRM4(1), CHRM5(2), CNR1(2), CNR2(1), CRHR1(3), CRHR2(3), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD2(1), DRD3(1), DRD5(2), EDNRA(3), EDNRB(1), F2(1), F2RL3(1), FPR1(1), GABBR1(5), GABBR2(1), GABRA1(3), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(3), GABRA6(3), GABRB1(1), GABRB3(1), GABRG1(4), GABRG2(2), GABRG3(2), GABRQ(4), GABRR1(1), GABRR2(2), GALR1(1), GH1(1), GH2(4), GHR(1), GHSR(2), GLP1R(2), GLP2R(3), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(1), GPR156(1), GPR35(1), GPR50(2), GPR63(4), GPR83(1), GRIA1(5), GRIA2(7), GRIA3(5), GRIA4(7), GRID1(1), GRID2(2), GRIK1(1), GRIK2(3), GRIK3(2), GRIK4(2), GRIN1(3), GRIN2A(2), GRIN2B(3), GRIN2D(1), GRIN3A(3), GRIN3B(3), GRM1(3), GRM2(2), GRM3(5), GRM4(2), GRM5(3), GRM6(2), GRM7(3), GRM8(4), GZMA(1), HCRTR1(1), HRH3(2), HRH4(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR2C(4), HTR5A(1), HTR6(1), HTR7(5), LEP(1), LEPR(3), LHB(2), LHCGR(4), LTB4R(1), MC2R(1), MC3R(1), MC4R(1), MC5R(2), MCHR1(1), MTNR1A(1), NMBR(2), NMUR1(1), NMUR2(1), NPBWR1(1), NPBWR2(1), NPFFR1(1), NPFFR2(1), NPY2R(2), NPY5R(4), NR3C1(2), OPRK1(1), OPRL1(1), OPRM1(4), OXTR(1), P2RX1(1), P2RX3(1), P2RY1(4), P2RY10(1), P2RY11(1), P2RY4(2), P2RY6(1), PARD3(4), PRL(2), PRLHR(2), PRSS1(1), PRSS3(1), PTGDR(1), PTGER2(1), PTGER3(2), PTGER4(1), PTGIR(2), PTH2R(2), RXFP1(1), RXFP2(1), SSTR2(1), SSTR3(2), SSTR4(2), SSTR5(1), TAAR1(1), TAAR2(2), TAAR5(1), TACR1(2), TACR2(2), TACR3(4), TRHR(4), TRPV1(1), TSHR(1), UTS2R(1), VIPR2(1)	64624790	312	136	311	119	117	73	63	19	40	0	0.873	1.000	1.000
418	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(1), ACTN1(3), ACTN2(2), APC(5), APC2(2), ARAF(2), ARHGEF1(1), ARHGEF12(3), ARHGEF4(2), ARHGEF6(3), ARHGEF7(3), ARPC1A(1), ARPC1B(1), ARPC2(1), BAIAP2(1), BCAR1(2), BDKRB2(3), CDC42(2), CFL1(1), CFL2(1), CHRM2(4), CHRM3(3), CHRM4(1), CHRM5(2), CYFIP2(3), DIAPH2(1), DIAPH3(2), DOCK1(6), EGF(4), EGFR(4), EZR(2), F2(1), FGD3(2), FGF11(1), FGF13(1), FGF14(1), FGF20(1), FGF3(1), FGF6(2), FGFR2(3), FGFR3(1), FGFR4(1), FN1(7), GNA13(2), GNG12(1), GSN(1), IQGAP1(3), IQGAP2(3), IQGAP3(1), ITGA1(3), ITGA10(6), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAD(6), ITGAE(1), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(1), ITGB1(1), ITGB2(2), ITGB4(5), ITGB5(3), ITGB6(1), ITGB7(1), ITGB8(2), KRAS(4), LIMK2(2), MAP2K1(1), MAP2K2(2), MAPK1(1), MOS(1), MRAS(1), MSN(2), MYH10(3), MYH14(3), MYH9(2), MYLK2(1), NCKAP1(2), NCKAP1L(2), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PDGFA(1), PDGFB(1), PDGFRA(4), PDGFRB(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP5K1B(1), PIP5K1C(1), PPP1CA(2), PPP1CC(1), PPP1R12A(3), PPP1R12B(1), PTK2(6), PXN(1), RAC2(1), RAF1(1), ROCK1(3), ROCK2(3), SCIN(2), SOS1(4), SOS2(2), SSH1(1), SSH2(1), SSH3(2), TIAM1(1), TIAM2(4), VAV1(3), VAV2(1), VAV3(4), VCL(3), WAS(1), WASF2(2), WASL(1)	83242327	295	133	293	83	146	43	51	12	43	0	0.0422	1.000	1.000
419	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(1), COL11A1(10), COL11A2(1), COL1A1(1), COL1A2(3), COL2A1(4), COL3A1(3), COL4A1(3), COL4A2(4), COL4A4(6), COL4A6(4), COL5A1(6), COL5A2(7), COL5A3(3), COL6A1(1), COL6A2(3), COL6A3(10), COL6A6(13), DES(1), DSC2(2), DSG2(1), DSG3(2), DSG4(1), FN1(7), GJA1(2), GJA5(1), GJA8(4), GJB1(1), GJB4(1), GJB5(1), GJC1(1), GJD2(1), IBSP(2), ITGB4(5), KRT1(5), KRT10(1), KRT14(2), KRT15(1), KRT16(1), KRT17(1), KRT18(1), KRT19(2), KRT2(1), KRT23(1), KRT25(1), KRT27(4), KRT28(1), KRT3(1), KRT31(2), KRT32(2), KRT33A(1), KRT33B(3), KRT34(3), KRT35(3), KRT36(2), KRT37(1), KRT38(3), KRT39(2), KRT4(1), KRT40(3), KRT5(3), KRT6A(1), KRT6B(2), KRT6C(2), KRT7(2), KRT71(1), KRT72(3), KRT73(2), KRT75(2), KRT76(1), KRT77(1), KRT78(2), KRT79(3), KRT8(1), KRT81(3), KRT83(2), KRT84(1), KRT85(2), KRT86(3), KRT9(1), LAMA1(11), LAMA2(5), LAMA3(7), LAMA4(2), LAMA5(5), LAMB1(1), LAMB2(2), LAMB3(3), LAMB4(4), LAMC1(6), LAMC2(3), LAMC3(4), LMNA(2), LMNB1(1), LMNB2(2), NES(5), RELN(5), SPP1(1), THBS1(3), THBS2(2), THBS3(3), THBS4(1), TNC(4), TNN(5), TNR(3), TNXB(8), VIM(3), VTN(1), VWF(5)	74471764	310	132	310	96	108	61	72	10	58	1	0.379	1.000	1.000
420	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(1), CD44(1), CD47(1), COL11A1(10), COL11A2(1), COL1A1(1), COL1A2(3), COL2A1(4), COL3A1(3), COL4A1(3), COL4A2(4), COL4A4(6), COL4A6(4), COL5A1(6), COL5A2(7), COL5A3(3), COL6A1(1), COL6A2(3), COL6A3(10), COL6A6(13), FN1(7), FNDC1(3), FNDC3A(1), GP6(2), HMMR(3), HSPG2(6), IBSP(2), ITGA1(3), ITGA10(6), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAV(4), ITGB1(1), ITGB4(5), ITGB5(3), ITGB6(1), ITGB7(1), ITGB8(2), LAMA1(11), LAMA2(5), LAMA3(7), LAMA4(2), LAMA5(5), LAMB1(1), LAMB2(2), LAMB3(3), LAMB4(4), LAMC1(6), LAMC2(3), LAMC3(4), RELN(5), SPP1(1), SV2A(2), SV2C(1), THBS1(3), THBS2(2), THBS3(3), THBS4(1), TNC(4), TNN(5), TNR(3), TNXB(8), VTN(1), VWF(5)	67627948	255	123	254	87	93	46	57	13	45	1	0.705	1.000	1.000
421	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABLIM1(2), ABLIM2(1), ARHGEF12(3), CDC42(2), CFL1(1), CFL2(1), CXCR4(1), DCC(7), DPYSL2(1), DPYSL5(2), EFNA3(1), EFNA4(1), EFNA5(2), EFNB2(2), EPHA1(4), EPHA2(2), EPHA3(6), EPHA4(2), EPHA5(5), EPHA6(4), EPHA7(3), EPHA8(3), EPHB1(3), EPHB2(4), EPHB3(4), FES(1), FYN(1), GNAI1(2), GNAI2(1), GSK3B(2), ITGB1(1), KRAS(4), L1CAM(4), LIMK2(2), LRRC4C(4), MAPK1(1), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NGEF(2), NRAS(1), NRP1(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PLXNA1(2), PLXNA2(3), PLXNA3(1), PLXNB1(3), PLXNB2(2), PLXNB3(6), PLXNC1(2), PPP3CA(4), PTK2(6), RAC2(1), RASA1(4), RGS3(1), ROBO1(8), ROBO2(9), ROBO3(1), ROCK1(3), ROCK2(3), SEMA3A(6), SEMA3C(3), SEMA3D(6), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4D(1), SEMA4F(2), SEMA5B(2), SEMA6A(5), SEMA6B(1), SEMA6C(3), SEMA6D(8), SEMA7A(4), SLIT1(2), SLIT2(8), SLIT3(1), SRGAP1(1), SRGAP2(1), SRGAP3(4), UNC5D(4)	58589345	246	120	246	82	108	52	44	14	26	2	0.528	1.000	1.000
422	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(3), ADCY2(7), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), ADRA1A(1), ADRA1B(1), ADRA1D(3), ADRB2(3), ANXA6(2), ARRB1(1), ARRB2(1), ATP1A4(3), ATP1B3(1), ATP2A3(1), ATP2B1(1), ATP2B2(4), CACNA1A(6), CACNA1B(6), CACNA1C(5), CACNA1D(3), CACNA1E(18), CACNA1S(2), CACNB1(1), CALR(3), CAMK2A(3), CAMK2B(1), CASQ1(2), CASQ2(1), CHRM2(4), CHRM3(3), CHRM4(1), CHRM5(2), GJA1(2), GJA5(1), GJB1(1), GJB4(1), GJB5(1), GNAI2(1), GNB1(1), GNB2(1), GNB4(1), GNB5(3), GNG12(1), GNG5(1), GRK6(1), ITPR1(6), ITPR2(3), ITPR3(8), KCNJ3(1), MIB1(2), PLCB3(2), PRKACA(1), PRKACB(1), PRKAR2B(1), PRKCA(1), PRKCG(1), PRKCH(3), PRKCQ(2), PRKCZ(1), PRKD1(2), RGS11(1), RGS14(1), RGS16(2), RGS18(2), RGS20(1), RGS3(1), RGS4(1), RGS7(4), RGS9(2), RYR1(8), RYR2(25), RYR3(13), SLC8A1(4), USP5(3), YWHAH(1)	56813080	232	119	232	76	85	54	46	10	37	0	0.601	1.000	1.000
423	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR1(1), ACVR1B(1), ACVR2A(6), ACVR2B(1), AMH(1), AMHR2(1), BMP2(1), BMP7(2), BMPR1A(1), BMPR1B(1), BMPR2(3), CCL11(1), CCL13(1), CCL14(1), CCL15(1), CCL18(1), CCL25(1), CCL3(1), CCL8(1), CCR1(2), CCR2(2), CCR3(1), CCR6(4), CCR7(4), CCR8(1), CCR9(1), CD27(1), CD70(1), CLCF1(1), CRLF2(1), CSF2RB(1), CXCL1(1), CXCL14(1), CXCR3(1), CXCR4(1), CXCR6(1), EDA(1), EDAR(1), EGF(4), EGFR(4), FASLG(1), FLT1(4), FLT3(2), FLT3LG(2), FLT4(6), GDF5(2), GH1(1), GH2(4), GHR(1), HGF(5), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(1), IFNB1(1), IFNG(2), IFNGR1(2), IFNW1(2), IL10RA(3), IL11RA(1), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL17RA(1), IL18(2), IL18R1(1), IL18RAP(4), IL1B(1), IL1R1(3), IL20RA(2), IL21(1), IL21R(5), IL23A(1), IL23R(2), IL2RB(3), IL4(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL7(1), IL7R(1), IL9R(2), INHBA(2), INHBE(1), KDR(9), KIT(5), KITLG(2), LEP(1), LEPR(3), LIF(1), LIFR(2), LTA(1), NGFR(1), PDGFB(1), PDGFC(1), PDGFRA(4), PDGFRB(1), PF4V1(1), PLEKHO2(1), PPBP(1), PRL(2), RELT(1), TGFB2(2), TGFB3(2), TGFBR1(1), TNF(2), TNFRSF10D(1), TNFRSF11A(1), TNFRSF11B(5), TNFRSF18(1), TNFRSF1A(1), TNFRSF21(2), TNFRSF25(1), TNFRSF4(3), TNFRSF6B(1), TNFRSF8(1), TNFSF13B(1), TPO(9), TSLP(1), VEGFC(3)	51942521	245	118	245	51	91	44	55	15	39	1	0.00138	1.000	1.000
424	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(3), ACACB(6), AKT2(3), AKT3(1), ARAF(2), CBL(1), CBLB(2), EXOC7(1), FASN(10), FLOT1(2), FLOT2(1), G6PC(1), GSK3B(2), GYS1(2), GYS2(1), IKBKB(3), INSR(6), IRS2(1), IRS4(5), KRAS(4), LIPE(1), MAP2K1(1), MAP2K2(2), MAPK1(1), MAPK10(3), MAPK9(1), MKNK1(1), MKNK2(1), NRAS(1), PCK1(5), PDE3A(5), PFKL(1), PFKP(2), PHKA1(2), PHKA2(2), PHKB(5), PHKG2(3), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PPARGC1A(3), PPP1CA(2), PPP1CC(1), PPP1R3A(5), PPP1R3B(1), PRKAA1(3), PRKAB2(1), PRKACA(1), PRKACB(1), PRKAG2(1), PRKAR2B(1), PRKCZ(1), PRKX(2), PTPRF(1), PYGB(1), PYGL(1), PYGM(5), RAF1(1), RAPGEF1(4), RPS6KB1(1), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(1), SHC4(3), SLC2A4(1), SORBS1(2), SOS1(4), SOS2(2), SREBF1(4), TRIP10(1), TSC1(7), TSC2(9)	47787489	190	114	189	43	100	25	22	7	36	0	0.00462	1.000	1.000
425	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(3), ADCY2(7), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), ARRB1(1), ARRB2(1), ATF5(1), ATP2A3(1), CAMK2A(3), CAMK2B(1), CORIN(3), CRHR1(3), DGKZ(1), ETS2(1), FOS(2), GJA1(2), GNB1(1), GNB2(1), GNB4(1), GNB5(3), GNG12(1), GNG5(1), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP2(1), IGFBP3(1), IGFBP4(2), IL1B(1), IL6(2), ITPR1(6), ITPR2(3), ITPR3(8), JUN(1), MIB1(2), MYLK2(1), NFKB1(2), NOS1(9), NOS3(2), OXTR(1), PDE4B(2), PDE4D(2), PLCB3(2), PLCD1(1), PLCG1(3), PLCG2(5), PRKACA(1), PRKACB(1), PRKAR2B(1), PRKCA(1), PRKCH(3), PRKCQ(2), PRKCZ(1), PRKD1(2), RGS11(1), RGS14(1), RGS16(2), RGS18(2), RGS20(1), RGS3(1), RGS4(1), RGS7(4), RGS9(2), RYR1(8), RYR2(25), RYR3(13), SLC8A1(4), SP1(2), TNXB(8), USP5(3), YWHAH(1)	52146524	208	113	208	61	86	42	39	10	31	0	0.232	1.000	1.000
426	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTG1(1), ACTN1(3), ACTN2(2), AKT2(3), AKT3(1), AMOTL1(2), ASH1L(2), CDC42(2), CGN(1), CLDN1(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN20(1), CSNK2A1(1), CTNNA1(1), CTNNA2(3), CTNNA3(2), CTTN(2), EPB41L1(1), EPB41L2(1), EPB41L3(6), EXOC3(3), EXOC4(4), GNAI1(2), GNAI2(1), IGSF5(2), INADL(7), JAM2(1), JAM3(3), KRAS(4), MAGI1(1), MAGI2(5), MAGI3(1), MLLT4(3), MPDZ(4), MRAS(1), MYH1(5), MYH10(3), MYH11(4), MYH13(1), MYH14(3), MYH15(10), MYH2(3), MYH3(1), MYH4(6), MYH6(3), MYH7(8), MYH7B(2), MYH8(3), MYH9(2), NRAS(1), OCLN(1), PARD3(4), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R2C(2), PPP2R3A(3), PPP2R4(3), PRKCA(1), PRKCG(1), PRKCH(3), PRKCQ(2), PRKCZ(1), SPTAN1(4), SRC(1), TJAP1(1), TJP1(6), TJP2(2), YES1(2), ZAK(1)	56467658	179	108	179	65	74	33	34	9	29	0	0.827	1.000	1.000
427	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM1(5), CD22(3), CD276(1), CD4(1), CD6(2), CD80(1), CD86(1), CD8B(1), CD99(1), CDH1(2), CDH15(4), CDH2(1), CDH3(1), CDH4(2), CDH5(2), CLDN1(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN20(1), CNTN1(2), CNTN2(3), CNTNAP2(5), CTLA4(1), GLG1(3), HLA-B(1), HLA-DMA(1), HLA-DMB(2), HLA-DPB1(1), HLA-E(3), HLA-G(1), ICAM1(1), ICAM3(1), ITGA4(2), ITGA8(3), ITGA9(4), ITGAL(3), ITGAM(1), ITGAV(4), ITGB1(1), ITGB2(2), ITGB7(1), ITGB8(2), JAM2(1), JAM3(3), L1CAM(4), MAG(2), NCAM1(4), NCAM2(2), NEGR1(1), NEO1(4), NFASC(3), NLGN1(8), NLGN3(2), NRCAM(2), NRXN1(4), NRXN2(1), NRXN3(3), OCLN(1), PDCD1(1), PTPRC(4), PTPRF(1), PTPRM(8), PVR(1), PVRL1(1), PVRL2(2), SELE(1), SELL(1), SELP(1), SIGLEC1(3), SPN(1), VCAM1(1), VCAN(12)	43601172	165	104	165	61	77	33	27	7	21	0	0.745	1.000	1.000
428	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT2(3), AKT3(1), CBL(1), CBLB(2), CCND2(1), CISH(2), CLCF1(1), CREBBP(6), CRLF2(1), CSF2RB(1), EP300(3), GH1(1), GH2(4), GHR(1), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(1), IFNB1(1), IFNG(2), IFNGR1(2), IFNW1(2), IL10RA(3), IL11RA(1), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL13RA2(1), IL20RA(2), IL21(1), IL21R(5), IL23A(1), IL23R(2), IL2RB(3), IL4(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL7(1), IL7R(1), IL9R(2), IRF9(1), JAK1(2), JAK2(4), JAK3(3), LEP(1), LEPR(3), LIF(1), LIFR(2), MYC(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PRL(2), PTPN11(1), PTPN6(1), SOCS5(1), SOS1(4), SOS2(2), SPRY2(1), SPRY3(1), STAM(1), STAT1(2), STAT2(1), STAT3(3), STAT4(3), STAT5A(2), STAT5B(1), STAT6(1), TPO(9), TSLP(1), TYK2(2)	42495236	171	103	170	41	74	30	32	11	24	0	0.0511	1.000	1.000
429	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(2), CD244(2), FASLG(1), FCGR3A(1), FYN(1), GZMB(1), HLA-B(1), HLA-E(3), HLA-G(1), ICAM1(1), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(1), IFNB1(1), IFNG(2), IFNGR1(2), ITGAL(3), ITGB2(2), KIR2DL3(4), KLRK1(3), KRAS(4), LCK(3), LCP2(3), MAP2K1(1), MAP2K2(2), MAPK1(1), MICA(2), NCR1(1), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NRAS(1), PAK1(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLCG1(3), PLCG2(5), PPP3CA(4), PRF1(3), PRKCA(1), PRKCG(1), PTK2B(4), PTPN11(1), PTPN6(1), RAC2(1), RAF1(1), SH3BP2(1), SHC1(2), SHC2(1), SHC4(3), SOS1(4), SOS2(2), SYK(1), TNF(2), TNFRSF10D(1), VAV1(3), VAV2(1), VAV3(4), ZAP70(1)	33482480	148	101	147	35	72	21	27	11	17	0	0.0318	1.000	1.000
430	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(3), ADCY2(7), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), DRD2(1), EGF(4), EGFR(4), GJA1(2), GJD2(1), GNAI1(2), GNAI2(1), GNAS(7), GRM1(3), GRM5(3), GUCY1A2(2), GUCY1A3(1), GUCY1B3(4), GUCY2C(3), GUCY2F(1), HTR2C(4), ITPR1(6), ITPR2(3), ITPR3(8), KRAS(4), MAP2K1(1), MAP2K2(2), MAP3K2(1), MAPK1(1), MAPK7(4), NPR1(2), NPR2(1), NRAS(1), PDGFA(1), PDGFB(1), PDGFC(1), PDGFD(2), PDGFRA(4), PDGFRB(1), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKG1(3), PRKX(2), RAF1(1), SOS1(4), SOS2(2), SRC(1), TJP1(6), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBA8(2), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB2B(1), TUBB6(1), TUBB8(3)	39436688	175	100	173	47	81	33	34	4	23	0	0.0906	1.000	1.000
431	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	AKT2(3), AKT3(1), ARAF(2), BTC(1), CAMK2A(3), CAMK2B(1), CBL(1), CBLB(2), EGF(4), EGFR(4), ERBB3(6), ERBB4(4), GAB1(3), GSK3B(2), JUN(1), KRAS(4), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK9(1), MYC(1), NRAS(1), NRG1(2), NRG2(1), NRG3(2), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLCG1(3), PLCG2(5), PRKCA(1), PRKCG(1), PTK2(6), RAF1(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SHC2(1), SHC4(3), SOS1(4), SOS2(2), SRC(1), STAT5A(2), STAT5B(1), TGFA(1)	30510532	131	95	130	26	63	22	23	3	20	0	0.0104	1.000	1.000
432	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(5), APC2(2), AXIN2(3), BTRC(1), CAMK2A(3), CAMK2B(1), CCND2(1), CER1(2), CHD8(3), CREBBP(6), CSNK1A1L(3), CSNK1E(2), CSNK2A1(1), CUL1(1), DAAM1(2), DAAM2(1), DKK1(1), DKK2(2), DVL1(1), DVL2(4), EP300(3), FBXW11(1), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD4(1), FZD5(1), FZD9(2), GSK3B(2), JUN(1), LEF1(2), LRP5(2), LRP6(1), MAP3K7(1), MAPK10(3), MAPK9(1), MMP7(2), MYC(1), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NKD1(1), NKD2(1), NLK(1), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R2C(2), PPP3CA(4), PRICKLE1(4), PRICKLE2(6), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKX(2), PSEN1(1), RAC2(1), ROCK1(3), ROCK2(3), SENP2(4), SFRP2(1), SFRP4(1), SIAH1(4), SMAD3(2), TBL1XR1(1), TBL1Y(1), TCF7(2), TCF7L1(3), TCF7L2(2), VANGL2(1), WIF1(1), WNT1(2), WNT2(1), WNT3A(1), WNT4(1), WNT6(2), WNT8A(1), WNT8B(1), WNT9B(1)	46168895	177	95	177	42	68	29	35	10	35	0	0.0618	1.000	1.000
433	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(3), ADCY2(7), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), CACNA1C(5), CACNA1D(3), CACNA1F(1), CACNA1S(2), CAMK2A(3), CAMK2B(1), CDC42(2), EGFR(4), GNAS(7), GNRH2(1), ITPR1(6), ITPR2(3), ITPR3(8), JUN(1), KRAS(4), LHB(2), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K1(2), MAP3K2(1), MAP3K4(4), MAPK1(1), MAPK10(3), MAPK14(2), MAPK7(4), MAPK9(1), MMP14(1), MMP2(1), NRAS(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), PLD1(2), PLD2(2), PRKACA(1), PRKACB(1), PRKCA(1), PRKX(2), PTK2B(4), RAF1(1), SOS1(4), SOS2(2), SRC(1)	38707887	162	94	160	38	74	33	25	4	26	0	0.0254	1.000	1.000
434	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(2), CACNA1A(6), CRHR1(3), GNA13(2), GNAI1(2), GNAI2(1), GNAS(7), GRIA1(5), GRIA2(7), GRIA3(5), GRID2(2), GRM1(3), GRM5(3), GUCY1A2(2), GUCY1A3(1), GUCY1B3(4), GUCY2C(3), GUCY2F(1), IGF1R(6), ITPR1(6), ITPR2(3), ITPR3(8), KRAS(4), LYN(1), MAP2K1(1), MAP2K2(2), MAPK1(1), NOS1(9), NOS3(2), NPR1(2), NPR2(1), NRAS(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R2C(2), PRKCA(1), PRKCG(1), PRKG1(3), RAF1(1), RYR1(8)	33124467	158	93	156	46	75	34	27	2	20	0	0.142	1.000	1.000
435	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT3(1), BCAR1(2), CAPN1(1), CAPN10(1), CAPN11(4), CAPN3(2), CAPN6(1), CAPN9(2), CAPNS1(1), CAV1(1), CAV2(1), CDC42(2), DOCK1(6), FYN(1), GIT2(1), ITGA10(6), ITGA11(4), ITGA2(1), ITGA2B(1), ITGA3(3), ITGA4(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAD(6), ITGAE(1), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(1), ITGB1(1), ITGB2(2), ITGB4(5), ITGB5(3), ITGB6(1), ITGB7(1), ITGB8(2), MAP2K1(1), MAP2K2(2), MAPK10(3), MAPK4(1), MAPK6(2), MAPK7(4), MYLK2(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PIK3R2(3), PTK2(6), PXN(1), RAC2(1), RAPGEF1(4), RHO(1), ROCK1(3), ROCK2(3), SDCCAG8(3), SHC1(2), SORBS1(2), SOS1(4), SRC(1), TLN1(3), TNS1(3), VASP(1), VAV2(1), VAV3(4), VCL(3), ZYX(1)	40636285	156	92	155	49	74	25	26	8	23	0	0.412	1.000	1.000
436	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(3), ACTN2(2), ARHGAP5(2), BCAR1(2), CD99(1), CDC42(2), CDH5(2), CLDN1(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN20(1), CTNNA1(1), CTNNA2(3), CTNNA3(2), CTNND1(1), CXCR4(1), CYBA(1), EZR(2), GNAI1(2), GNAI2(1), ICAM1(1), ITGA4(2), ITGAL(3), ITGAM(1), ITGB1(1), ITGB2(2), JAM2(1), JAM3(3), MAPK14(2), MLLT4(3), MMP2(1), MMP9(1), MSN(2), NCF2(1), NCF4(1), NOX1(3), NOX3(4), OCLN(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLCG1(3), PLCG2(5), PRKCA(1), PRKCG(1), PTK2(6), PTK2B(4), PTPN11(1), PXN(1), RAC2(1), RAP1A(1), RAPGEF3(2), RHOH(1), ROCK1(3), ROCK2(3), TXK(2), VASP(1), VAV1(3), VAV2(1), VAV3(4), VCAM1(1), VCL(3)	36569033	136	90	135	32	69	23	21	5	18	0	0.0280	1.000	1.000
437	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(2), DES(1), DMD(14), MYBPC1(1), MYBPC2(2), MYBPC3(3), MYH3(1), MYH6(3), MYH7(8), MYH8(3), MYOM1(2), NEB(11), TCAP(1), TNNC2(1), TNNI2(2), TNNT2(1), TNNT3(1), TPM1(2), TPM2(3), TTN(75), VIM(3)	41737524	140	90	139	51	57	19	38	8	18	0	0.856	1.000	1.000
438	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(3), ADCY8(5), ARAF(2), CACNA1C(5), CAMK2A(3), CAMK2B(1), CREBBP(6), EP300(3), GRIA1(5), GRIA2(7), GRIN1(3), GRIN2A(2), GRIN2B(3), GRIN2D(1), GRM1(3), GRM5(3), ITPR1(6), ITPR2(3), ITPR3(8), KRAS(4), MAP2K1(1), MAP2K2(2), MAPK1(1), NRAS(1), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), PPP1CA(2), PPP1CC(1), PPP1R12A(3), PPP3CA(4), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKX(2), RAF1(1), RAP1A(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA6(5)	30250454	134	89	134	46	66	19	24	4	21	0	0.421	1.000	1.000
439	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA2A(1), ADORA2B(2), ADORA3(2), ADRA1A(1), ADRA1B(1), ADRA1D(3), ADRB2(3), AVPR1B(1), BDKRB2(3), C3AR1(1), CCKBR(3), CCR1(2), CCR2(2), CCR3(1), CCR6(4), CCR7(4), CCR8(1), CCR9(1), CHML(1), CHRM2(4), CHRM3(3), CHRM4(1), CHRM5(2), CMKLR1(1), CNR1(2), CNR2(1), CXCR3(1), CXCR4(1), DRD2(1), DRD3(1), DRD5(2), EDNRA(3), EDNRB(1), F2RL3(1), FPR1(1), GALR1(1), GALT(1), GHSR(2), GNB2L1(1), GPR17(2), GPR173(2), GPR174(2), GPR3(1), GPR35(1), GPR37(1), GPR50(2), GPR63(4), GPR83(1), GPR85(2), HCRTR1(1), HRH3(2), HTR1A(1), HTR1B(1), HTR1D(1), HTR2C(4), HTR5A(1), HTR6(1), HTR7(5), LHCGR(4), LTB4R(1), MC3R(1), MC4R(1), MC5R(2), MTNR1A(1), NMBR(2), NMUR1(1), NMUR2(1), NPY2R(2), NPY5R(4), OPRK1(1), OPRL1(1), OPRM1(4), OR10A5(1), OR11A1(2), OR12D3(3), OR1C1(1), OR5V1(2), OR7A5(1), OR8B8(2), OXTR(1), P2RY1(4), P2RY10(1), P2RY11(1), P2RY12(1), P2RY6(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGIR(2), RHO(1), SSTR2(1), SSTR3(2), SSTR4(2), SUCNR1(1), TRHR(4)	34832889	166	88	166	60	66	41	40	9	10	0	0.519	1.000	1.000
440	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(3), ADCY2(7), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), ADSL(1), ADSS(2), ADSSL1(1), AK2(1), AK5(1), AK7(2), ALLC(1), AMPD1(4), AMPD2(1), AMPD3(1), ENPP3(1), ENTPD1(3), ENTPD6(1), GART(1), GMPS(2), GUCY1A2(2), GUCY1A3(1), GUCY1B3(4), GUCY2C(3), GUCY2F(1), GUK1(1), IMPDH1(2), NME1(1), NME6(1), NPR1(2), NPR2(1), NT5C1B(1), NT5C2(1), NUDT5(1), PAICS(1), PDE10A(4), PDE11A(4), PDE1A(1), PDE1C(5), PDE4A(1), PDE4B(2), PDE4C(2), PDE4D(2), PDE7A(1), PDE7B(1), PDE8A(3), PDE9A(1), PFAS(1), POLA2(1), POLD1(2), POLE(3), POLE2(2), POLE3(1), POLR1A(1), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), POLR3A(1), POLR3B(1), PPAT(1), PRIM2(2), PRPS1L1(1), PRPS2(1), RFC5(2), RRM1(1), XDH(4)	48625911	139	88	139	47	55	26	26	5	27	0	0.568	1.000	1.000
441	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(3), ADCY2(7), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), CAMK2A(3), CAMK2B(1), CREB3L1(2), CREB3L3(2), CREBBP(6), DCT(1), DVL1(1), DVL2(4), EDN1(2), EDNRB(1), EP300(3), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD4(1), FZD5(1), FZD9(2), GNAI1(2), GNAI2(1), GNAS(7), GSK3B(2), KIT(5), KITLG(2), KRAS(4), LEF1(2), MAP2K1(1), MAP2K2(2), MAPK1(1), NRAS(1), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), POMC(2), PRKACA(1), PRKACB(1), PRKCA(1), PRKCG(1), PRKX(2), RAF1(1), TCF7(2), TCF7L1(3), TCF7L2(2), TYR(4), WNT1(2), WNT2(1), WNT3A(1), WNT4(1), WNT6(2), WNT8A(1), WNT8B(1), WNT9B(1)	31556502	144	88	142	38	63	29	21	6	25	0	0.105	1.000	1.000
442	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	77	ACTN1(3), ACTR3(1), AKT2(3), AKT3(1), ARHGEF6(3), ARHGEF7(3), BCAR1(2), CAV1(1), CDC42(2), CDKN2A(1), DOCK1(6), EPHB2(4), FYN(1), GRB7(2), ITGA1(3), ITGA10(6), ITGA11(4), ITGA2(1), ITGA3(3), ITGA4(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGB3BP(1), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK8IP3(1), MAPK9(1), MRAS(1), MYLK2(1), P4HB(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PIK3CA(7), PIK3CB(1), PLCG1(3), PLCG2(5), PTK2(6), RAF1(1), RHO(1), ROCK1(3), ROCK2(3), SHC1(2), SOS1(4), SOS2(2), SRC(1), TLN1(3), TLN2(2), VASP(1), WAS(1), ZYX(1)	36163519	137	85	136	32	64	23	24	6	20	0	0.0489	1.000	1.000
443	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(1), ACTG1(1), ACTN1(3), ACTN2(2), ACVR1B(1), ACVR1C(1), BAIAP2(1), CDC42(2), CDH1(2), CREBBP(6), CSNK2A1(1), CTNNA1(1), CTNNA2(3), CTNNA3(2), CTNND1(1), EGFR(4), EP300(3), FARP2(2), FER(1), FYN(1), IGF1R(6), INSR(6), IQGAP1(3), LEF1(2), LMO7(4), MAP3K7(1), MAPK1(1), MLLT4(3), NLK(1), PARD3(4), PTPN6(1), PTPRB(6), PTPRF(1), PTPRJ(1), PTPRM(8), PVRL1(1), PVRL2(2), RAC2(1), SMAD3(2), SNAI1(2), SORBS1(2), SRC(1), SSX2IP(1), TCF7(2), TCF7L1(3), TCF7L2(2), TGFBR1(1), TJP1(6), VCL(3), WAS(1), WASF2(2), WASF3(2), WASL(1), YES1(2)	35122222	124	84	124	41	59	15	21	4	25	0	0.434	1.000	1.000
444	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(3), ADCY2(7), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADSL(1), ADSS(2), AK2(1), AK5(1), ALLC(1), AMPD1(4), AMPD2(1), AMPD3(1), ATP5A1(1), ATP5B(3), ATP5C1(1), ATP5G3(1), ENPP3(1), ENTPD1(3), GART(1), GMPS(2), GUCY1A2(2), GUCY1A3(1), GUCY1B3(4), GUCY2C(3), GUCY2F(1), GUK1(1), IMPDH1(2), NME1(1), NPR1(2), NPR2(1), PAICS(1), PDE1A(1), PDE4A(1), PDE4B(2), PDE4C(2), PDE4D(2), PDE6B(3), PDE7B(1), PDE8A(3), PDE9A(1), PFAS(1), POLD1(2), POLE(3), POLG(4), POLQ(7), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), PPAT(1), PRPS1L1(1), PRPS2(1), RRM1(1)	38049270	121	84	121	37	55	26	20	3	17	0	0.277	1.000	1.000
445	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CDIPT(1), DGKE(2), DGKG(5), DGKH(1), DGKI(1), DGKZ(1), IMPA1(1), IMPA2(2), INPP4A(1), INPP4B(2), INPP5A(1), INPP5B(1), INPPL1(3), ITPK1(1), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), OCRL(2), PI4KA(2), PI4KB(1), PIK3C2A(3), PIK3C2B(5), PIK3C2G(5), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP5K1B(1), PIP5K1C(1), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(4), PLCG1(3), PLCG2(5), PLCZ1(1), PRKCA(1), PRKCG(1), SYNJ1(2), SYNJ2(1)	37298261	124	83	123	47	65	21	14	4	20	0	0.655	1.000	1.000
446	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT2(3), AKT3(1), BCL10(1), CARD11(8), CBL(1), CBLB(2), CD4(1), CD8B(1), CDC42(2), CHUK(2), CTLA4(1), FOS(2), FYN(1), GRAP2(2), IFNG(2), IKBKB(3), IL4(1), JUN(1), KRAS(4), LCK(3), LCP2(3), MALT1(3), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NFKB1(2), NFKBIA(2), NFKBIB(1), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PDCD1(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLCG1(3), PPP3CA(4), PRKCQ(2), PTPN6(1), PTPRC(4), RASGRP1(3), SOS1(4), SOS2(2), TNF(2), VAV1(3), VAV2(1), VAV3(4), ZAP70(1)	29987871	136	83	135	30	68	20	24	6	18	0	0.0270	1.000	1.000
447	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT2(3), AKT3(1), CASP8(1), CCL3(1), CD80(1), CD86(1), CHUK(2), FADD(2), FOS(2), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), IFNAR1(1), IFNB1(1), IKBKB(3), IKBKE(1), IL12A(5), IL12B(1), IL1B(1), IL6(2), IRAK1(2), IRAK4(2), IRF3(1), JUN(1), LBP(2), LY96(1), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K7(1), MAPK1(1), MAPK10(3), MAPK14(2), MAPK9(1), MYD88(1), NFKB1(2), NFKBIA(2), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), RELA(1), RIPK1(2), SPP1(1), STAT1(2), TBK1(1), TICAM1(2), TLR2(1), TLR3(1), TLR4(2), TLR5(1), TLR7(2), TLR8(5), TLR9(2), TNF(2), TRAF6(1)	26462120	117	82	116	31	59	15	21	7	15	0	0.171	1.000	1.000
448	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(3), ADCY2(7), ADCY3(4), ADCY4(2), ADCY5(4), ADCY6(2), ADCY7(1), ADCY8(5), ADCY9(1), AKAP1(3), AKAP11(3), AKAP12(2), AKAP2(2), AKAP3(3), AKAP4(5), AKAP6(2), AKAP8(3), AKAP9(4), ARHGEF1(1), GNA13(2), GNA15(1), GNAI2(1), GNAL(2), GNB1(1), GNB2(1), GNB5(3), GNG12(1), GNG5(1), ITPR1(6), KCNJ3(1), KRAS(4), NRAS(1), PDE1A(1), PDE1B(1), PDE1C(5), PDE4A(1), PDE4B(2), PDE4C(2), PDE4D(2), PDE7A(1), PDE7B(1), PDE8A(3), PLCB3(2), PPP3CA(4), PRKACA(1), PRKACB(1), PRKAR2B(1), PRKCA(1), PRKCG(1), PRKCH(3), PRKCQ(2), PRKCZ(1), PRKD1(2), USP5(3)	34373821	123	81	123	34	59	27	15	3	19	0	0.194	1.000	1.000
449	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(2), ABCA12(7), ABCA13(24), ABCA2(2), ABCA3(3), ABCA4(10), ABCA5(1), ABCA6(4), ABCA7(5), ABCA8(1), ABCA9(2), ABCB1(5), ABCB10(2), ABCB11(2), ABCB4(2), ABCB5(9), ABCB6(1), ABCB7(1), ABCC10(3), ABCC11(2), ABCC2(2), ABCC3(4), ABCC4(4), ABCC5(2), ABCC6(1), ABCC8(6), ABCC9(4), ABCD1(1), ABCD2(3), ABCG1(1), ABCG2(2), ABCG5(1), CFTR(5), TAP1(2)	35491477	132	81	132	35	48	28	23	6	27	0	0.133	1.000	1.000
450	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(1), ACVR1B(1), ACVRL1(2), BMPR1A(1), BMPR2(3), BUB1(1), CDIPT(1), CDKL2(1), CLK2(1), CLK4(3), COL4A3BP(1), CSNK2A1(1), DGKE(2), DGKG(5), DGKH(1), DGKZ(1), IMPA1(1), INPP4A(1), INPP4B(2), INPP5A(1), INPPL1(3), ITPKB(1), MOS(1), OCRL(2), PAK4(1), PIK3C2A(3), PIK3C2B(5), PIK3C2G(5), PIK3CA(7), PIK3CB(1), PIK3CG(2), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(5), PRKACA(1), PRKACB(1), PRKAR2B(1), PRKCA(1), PRKCG(1), PRKCH(3), PRKCQ(2), PRKCZ(1), PRKD1(2), PRKG1(3), RAF1(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA4(1), RPS6KB1(1), TGFBR1(1)	33950049	119	81	118	46	57	20	19	2	21	0	0.745	1.000	1.000
451	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(1), ACVR1B(1), ACVR1C(1), ACVR2A(6), ACVR2B(1), ACVRL1(2), AMH(1), AMHR2(1), BMP2(1), BMP5(3), BMP7(2), BMPR1A(1), BMPR1B(1), BMPR2(3), CHRD(1), CREBBP(6), CUL1(1), DCN(2), EP300(3), GDF5(2), IFNG(2), INHBA(2), INHBE(1), LTBP1(4), MAPK1(1), MYC(1), NOG(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R2C(2), RBL1(3), RBL2(5), ROCK1(3), ROCK2(3), RPS6KB1(1), RPS6KB2(1), SMAD3(2), SMAD5(2), SMAD7(1), SMAD9(1), SMURF1(2), SP1(2), TFDP1(1), TGFB2(2), TGFB3(2), TGFBR1(1), THBS1(3), THBS2(2), THBS3(3), THBS4(1), TNF(2), ZFYVE16(3), ZFYVE9(4)	29024049	108	80	108	27	49	11	19	5	22	2	0.0807	1.000	1.000
452	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(6), ACSL1(1), ACSL5(1), ACSL6(1), ADIPOR1(1), ADIPOR2(1), AKT2(3), AKT3(1), CAMKK2(1), CD36(1), CHUK(2), CPT1A(3), CPT1B(3), CPT1C(2), G6PC(1), IKBKB(3), IRS2(1), IRS4(5), JAK1(2), JAK2(4), JAK3(3), LEP(1), LEPR(3), MAPK10(3), MAPK9(1), NFKB1(2), NFKBIA(2), NFKBIB(1), PCK1(5), POMC(2), PPARA(2), PPARGC1A(3), PRKAA1(3), PRKAB2(1), PRKAG2(1), PRKCQ(2), PTPN11(1), RELA(1), RXRA(5), RXRB(2), RXRG(1), SLC2A4(1), STAT3(3), TNF(2), TNFRSF1A(1), TYK2(2)	24621081	97	76	97	33	45	16	20	6	10	0	0.592	1.000	1.000
453	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT2(3), AKT3(1), BCL10(1), BLNK(2), BTK(1), CARD11(8), CD19(1), CD22(3), CD81(1), CHUK(2), CR2(5), FOS(2), GSK3B(2), IKBKB(3), JUN(1), KRAS(4), LYN(1), MALT1(3), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NFKB1(2), NFKBIA(2), NFKBIB(1), NRAS(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLCG2(5), PPP3CA(4), PTPN6(1), RAC2(1), SYK(1), VAV1(3), VAV2(1), VAV3(4)	22047851	103	75	102	22	55	15	14	4	15	0	0.0297	1.000	1.000
454	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT2(3), AKT3(1), BTK(1), FYN(1), IL4(1), KRAS(4), LCP2(3), LYN(1), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAPK1(1), MAPK10(3), MAPK14(2), MAPK9(1), MS4A2(3), NRAS(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLCG1(3), PLCG2(5), PRKCA(1), RAC2(1), RAF1(1), SOS1(4), SOS2(2), SYK(1), TNF(2), VAV1(3), VAV2(1), VAV3(4)	21024581	95	73	94	21	46	17	15	4	13	0	0.0621	1.000	1.000
455	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG1(1), ALG10B(1), ALG13(2), ALG2(1), ALG3(1), ALG6(1), ALG8(1), ALG9(2), B3GNT2(1), B3GNT7(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), CHPF(4), CHST1(1), CHST11(1), CHST12(1), CHST13(1), CHST2(3), CHST3(3), CHST7(1), CHSY1(1), DPAGT1(1), EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), FUT8(1), GALNT1(2), GALNT11(1), GALNT12(2), GALNT13(1), GALNT14(1), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(3), GALNT8(2), GALNTL5(2), GANAB(1), GCNT3(1), HS2ST1(2), MAN1A1(1), MAN1A2(2), MAN1C1(1), MAN2A1(3), MGAT1(1), MGAT2(1), MGAT3(2), MGAT5(2), MGAT5B(2), NDST1(1), NDST2(2), NDST3(1), NDST4(6), ST3GAL1(1), ST6GALNAC1(3), UST(1), WBSCR17(5)	32301272	98	72	97	35	48	23	12	5	10	0	0.483	1.000	1.000
456	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	83	AGL(3), AMY2A(2), AMY2B(1), ASCC3(6), ATP13A2(1), DDX18(1), DDX4(1), DDX41(1), DDX47(1), DDX50(4), DDX56(1), ENPP3(1), EP400(2), ERCC2(2), ERCC3(3), G6PC(1), GAA(1), GPI(2), GUSB(3), GYS1(2), GYS2(1), HK1(1), HK2(4), HK3(3), LYZL1(1), MGAM(5), MOV10L1(1), NUDT5(1), PGM3(2), PYGB(1), PYGL(1), PYGM(5), RAD54B(3), SETX(3), SI(4), SKIV2L2(1), SMARCA2(3), SMARCA5(1), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(2), UGT2B4(4), UGT2B7(2)	39246536	99	71	99	34	47	15	8	7	22	0	0.645	1.000	1.000
457	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ANAPC1(1), ANAPC5(1), ANAPC7(1), ATM(7), ATR(6), BUB1(1), BUB1B(1), CCNA1(1), CCNB1(1), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(1), CCNH(1), CDC14B(2), CDC27(1), CDC7(3), CDK7(1), CDKN2A(1), CHEK1(1), CHEK2(2), CREBBP(6), CUL1(1), E2F1(1), E2F3(2), EP300(3), ESPL1(1), FZR1(2), GSK3B(2), HDAC2(1), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM2(3), MCM3(1), MCM4(1), MCM5(1), MCM7(3), MDM2(1), PKMYT1(1), PLK1(1), PRKDC(11), RBL1(3), RBL2(5), SKP2(1), SMAD3(2), SMC1A(1), TFDP1(1), TGFB2(2), TGFB3(2), WEE1(2), YWHAE(2), YWHAH(1), YWHAZ(1)	39626426	107	71	106	24	38	12	30	9	18	0	0.0846	1.000	1.000
458	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	CHUK(2), FOS(2), IKBKB(3), JUN(1), MAP2K1(1), MAP2K2(2), MAP2K4(3), MAP3K1(2), MAP3K12(1), MAP3K2(1), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(1), MAP4K5(3), MAPK1(1), MAPK10(3), MAPK14(2), MAPK4(1), MAPK6(2), MAPK7(4), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MEF2A(3), MEF2C(1), MEF2D(1), MKNK1(1), MKNK2(1), MYC(1), NFKB1(2), NFKBIA(2), PAK1(1), RAF1(1), RELA(1), RIPK1(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA4(1), RPS6KA5(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SP1(2), STAT1(2), TGFB2(2), TGFB3(2), TGFBR1(1)	29104479	94	71	94	30	45	11	22	2	14	0	0.442	1.000	1.000
459	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AKT2(3), AKT3(1), APAF1(3), ATM(7), BCL2(1), BIRC2(1), BIRC3(1), CAPN1(1), CASP6(1), CASP8(1), CFLAR(1), CHUK(2), CSF2RB(1), DFFB(1), ENDOG(1), FADD(2), FASLG(1), IKBKB(3), IL1B(1), IL1R1(3), IRAK1(2), IRAK3(3), IRAK4(2), MYD88(1), NFKB1(2), NFKBIA(2), NTRK1(2), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIK3R1(2), PIK3R2(3), PIK3R3(1), PIK3R5(1), PPP3CA(4), PRKACA(1), PRKACB(1), PRKAR2B(1), RELA(1), RIPK1(2), TNF(2), TNFRSF10D(1), TNFRSF1A(1)	24661812	85	68	84	17	43	12	12	3	15	0	0.0287	1.000	1.000
460	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	BCL2(1), CABIN1(5), CAMK2B(1), CD69(2), CNR1(2), CREBBP(6), CSNK2A1(1), CTLA4(1), EP300(3), FCGR3A(1), FOS(2), GSK3B(2), IFNB1(1), IFNG(2), IL1B(1), IL4(1), IL6(2), JUNB(1), KPNA5(1), MAPK14(2), MAPK9(1), MEF2A(3), MEF2D(1), MYF5(1), NFAT5(4), NFATC2(3), NFATC3(1), NFATC4(4), NFKBIB(1), NUP214(3), PAK1(1), PIN1(1), PTPRC(4), RELA(1), SP1(2), SP3(3), TNF(2), TRPV6(1), VAV1(3), VAV2(1), VAV3(4), XPO5(1)	26660982	84	66	84	21	32	8	19	8	17	0	0.187	1.000	1.000
461	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	68	A2M(2), BDKRB2(3), C1QA(2), C1QC(1), C1S(1), C2(1), C3(8), C3AR1(1), C4B(1), C4BPA(1), C5(3), C6(1), C7(1), C8B(1), C9(2), CD46(2), CD55(1), CFB(1), CFH(4), CFI(2), CPB2(2), CR1(6), CR2(5), F10(3), F13A1(1), F13B(1), F2(1), F3(1), F5(4), F8(2), FGA(6), KLKB1(2), MASP2(1), PROC(1), PROS1(2), SERPINC1(2), SERPIND1(1), SERPINE1(1), THBD(1), VWF(5)	31229856	87	66	86	31	37	11	13	8	18	0	0.695	1.000	1.000
462	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(2), CD19(1), CD1B(1), CD1C(1), CD1D(1), CD1E(3), CD22(3), CD36(1), CD37(1), CD38(2), CD4(1), CD44(1), CD5(1), CD55(1), CD8B(1), CD9(1), CR1(6), CR2(5), DNTT(1), FCGR1A(2), FLT3(2), FLT3LG(2), IL11RA(1), IL1B(1), IL1R1(3), IL4(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL7(1), IL7R(1), IL9R(2), ITGA1(3), ITGA2(1), ITGA2B(1), ITGA3(3), ITGA4(2), ITGAM(1), KIT(5), KITLG(2), MME(5), TFRC(1), TNF(2), TPO(9)	24864788	90	66	90	30	33	14	19	5	19	0	0.642	1.000	1.000
463	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(1), CLK2(1), CLK3(1), CLK4(3), COL2A1(4), CPSF1(3), CPSF3(1), CPSF4(1), CSTF2(1), DDIT3(1), DDX20(1), DHX15(1), DHX16(4), DHX8(1), DHX9(6), DICER1(4), DNAJC8(1), FUS(2), GIPC1(1), NCBP1(1), NONO(1), NUDT21(1), NXF1(3), PAPOLA(1), POLR2A(5), PRPF4(1), PRPF4B(2), PRPF8(5), PSKH1(1), PTBP1(2), PTBP2(1), RBM5(1), RNGTT(2), SF3A1(2), SF3A3(1), SF3B1(3), SF3B2(1), SNRPA1(1), SNRPB(1), SNRPN(1), SPOP(4), SRPK1(1), SRRM1(1), TXNL4A(1), U2AF2(2), XRN2(1)	31363250	86	65	86	29	33	15	17	4	16	1	0.654	1.000	1.000
464	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ATM(7), BUB1(1), BUB1B(1), CCNA1(1), CCNB1(1), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(1), CCNH(1), CDAN1(2), CDC14B(2), CDC7(3), CDH1(2), CDKN2A(1), CHEK1(1), CHEK2(2), E2F1(1), E2F3(2), E2F6(2), EP300(3), ESPL1(1), GSK3B(2), HDAC2(1), HDAC3(1), HDAC4(2), HDAC8(1), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM2(3), MCM3(1), MCM4(1), MCM5(1), MCM7(3), MDM2(1), MPEG1(3), PLK1(1), PRKDC(11), PTPRA(2), RBL1(3), SKP2(1), TBC1D8(2), TFDP1(1), WEE1(2)	32072662	87	63	86	22	33	6	26	6	16	0	0.165	1.000	1.000
465	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	IMPA1(1), IMPA2(2), INPP4A(1), INPP4B(2), INPP5A(1), INPP5B(1), INPPL1(3), ITPK1(1), ITPKB(1), MINPP1(1), OCRL(2), PI4KA(2), PI4KB(1), PIK3CA(7), PIK3CB(1), PIK3CD(4), PIK3CG(2), PIP4K2A(1), PIP4K2B(1), PIP5K1B(1), PIP5K1C(1), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(4), PLCG1(3), PLCG2(5), PLCZ1(1), SYNJ1(2), SYNJ2(1)	21819882	75	61	74	27	40	14	7	2	12	0	0.525	1.000	1.000
466	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(1), APAF1(3), BAG4(2), BCL2(1), BIRC2(1), BIRC3(1), CASP6(1), CASP8(1), CFLAR(1), CHUK(2), CRADD(1), DFFB(1), FADD(2), GSN(1), LMNA(2), LMNB1(1), LMNB2(2), MAP3K1(2), MAP3K5(2), MDM2(1), NFKB1(2), NFKBIA(2), NUMA1(2), PRKDC(11), PSEN1(1), PTK2(6), RASA1(4), RELA(1), RIPK1(2), SPTAN1(4), TNF(2), TNFRSF1A(1), TRAF1(1)	20210203	68	60	67	20	27	11	9	5	16	0	0.429	1.000	1.000
467	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(1), ADAM17(4), ATP6AP1(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0D2(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), CDC42(2), CHUK(2), CXCL1(1), EGFR(4), IGSF5(2), IKBKB(3), JAM2(1), JAM3(3), JUN(1), LYN(1), MAP2K4(3), MAPK10(3), MAPK14(2), MAPK9(1), NFKB1(2), NFKBIA(2), PAK1(1), PLCG1(3), PLCG2(5), PTPN11(1), PTPRZ1(5), RELA(1), SRC(1), TJP1(6)	21060388	75	60	75	16	29	13	16	3	14	0	0.201	1.000	1.000
468	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	ATP8A1(4), AVPR1B(1), BDKRB2(3), C3AR1(1), CCKBR(3), CCR1(2), CCR2(2), CCR3(1), CCR6(4), CCR7(4), CCR8(1), CXCR3(1), CXCR4(1), CXCR6(1), EDNRA(3), EDNRB(1), FPR1(1), GALR1(1), GALT(1), GHSR(2), GNB2L1(1), LHCGR(4), MC2R(1), MC3R(1), MC4R(1), MC5R(2), NMBR(2), NPY2R(2), NPY5R(4), OPRK1(1), OPRL1(1), OPRM1(4), OXTR(1), SSTR2(1), SSTR3(2), SSTR4(2), TACR1(2), TACR2(2), TACR3(4), TRHR(4), TSHR(1)	14952380	81	59	81	29	33	19	17	5	7	0	0.540	1.000	1.000
469	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(2), DOT1L(4), EED(2), EHMT1(2), EHMT2(2), EZH1(1), FBXO11(1), HCFC1(1), HSF4(1), JMJD6(1), KDM6A(1), MEN1(1), NSD1(6), PPP1CA(2), PPP1CC(1), PRDM2(6), PRDM7(1), PRDM9(1), PRMT1(2), PRMT6(2), PRMT7(1), PRMT8(1), RBBP5(2), SATB1(4), SETD1A(5), SETD1B(2), SETD2(8), SETD8(2), SETDB1(1), SETDB2(2), SUV39H1(1), SUV39H2(1), SUV420H1(3), WHSC1(2), WHSC1L1(2)	37288254	77	58	77	26	36	11	7	10	13	0	0.483	1.000	1.000
470	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(2), ADCY8(5), CACNA1A(6), CACNA1B(6), GNAS(7), GNAT3(1), GNB1(1), GRM4(2), ITPR3(8), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(1), PRKX(2), SCNN1A(2), SCNN1G(2), TAS1R1(2), TAS1R2(2), TAS1R3(2), TAS2R1(1), TAS2R10(1), TAS2R16(2), TAS2R3(1), TAS2R39(2), TAS2R41(1), TAS2R46(2), TAS2R7(1), TAS2R9(1), TRPM5(1)	17135617	70	56	68	25	32	14	10	2	12	0	0.642	1.000	1.000
471	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR3(1), AKT2(3), AKT3(1), ARHGEF11(1), BTK(1), CDC42(2), CFL1(1), CFL2(1), INPPL1(3), ITPR1(6), ITPR2(3), ITPR3(8), MYLK2(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PIK3CA(7), PIK3CD(4), PIK3CG(2), PIK3R1(2), PPP1R13B(5), RACGAP1(1), RHO(1), ROCK1(3), ROCK2(3), SAG(1), WASL(1)	20672124	76	56	75	19	38	13	9	4	12	0	0.122	1.000	1.000
472	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT2(3), AKT3(1), ASAH1(1), DRD2(1), EGFR(4), EPHB2(4), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), KCNJ3(1), MAPK1(1), PIK3CB(1), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), RAF1(1), RGS20(1), SHC1(2), SOS1(4), SOS2(2), SRC(1), STAT3(3)	17312297	67	56	67	21	32	11	15	3	6	0	0.542	1.000	1.000
473	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(1), BTK(1), CAD(2), CASP8(1), DEDD2(1), EGFR(4), EPHB2(4), FADD(2), FAF1(2), FAIM2(1), MAP2K4(3), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK10(3), MAPK8IP3(1), MAPK9(1), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIB(1), NR0B2(2), PTPN13(11), RALBP1(1), RIPK1(2), ROCK1(3), TNFRSF6B(1), TPX2(2)	21753329	63	55	63	19	26	9	9	2	17	0	0.552	1.000	1.000
474	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), ALG6(1), CCKBR(3), CCR2(2), CCR3(1), CELSR1(8), CELSR2(7), CELSR3(3), CHRM2(4), CHRM3(3), CXCR3(1), EDNRA(3), EMR2(1), EMR3(4), GPR116(3), GPR132(3), GPR133(2), GPR135(2), GPR17(2), GPR56(1), GPR61(1), GPR84(4), GRM1(3), HRH4(1), LGR6(2), LPHN2(2), LPHN3(4), P2RY11(1), SSTR2(1), TAAR5(1), TSHR(1)	19440019	77	53	77	33	37	15	14	0	11	0	0.822	1.000	1.000
475	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT1(2), AGPAT3(2), AGPAT4(1), AGPAT6(2), CDIPT(1), CHAT(4), CHKA(1), CHPT1(1), DGKE(2), DGKG(5), DGKH(1), DGKI(1), DGKZ(1), ESCO1(2), ESCO2(2), GNPAT(1), GPAM(3), GPD1L(1), PCYT1A(1), PCYT1B(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLD1(2), PLD2(2), PNPLA3(1), PPAP2A(3), PPAP2C(3), PTDSS1(1), SH3GLB1(1)	19680834	63	53	63	21	33	13	7	1	9	0	0.332	1.000	1.000
476	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(3), ATM(7), ATR(6), BAI1(4), CASP8(1), CCNB1(1), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(1), CDKN2A(1), CHEK1(1), CHEK2(2), DDB2(1), EI24(2), GTSE1(1), IGFBP3(1), MDM2(1), RFWD2(2), RPRM(1), SERPINE1(1), SESN1(1), SESN2(4), SESN3(2), SIAH1(4), STEAP3(2), THBS1(3), TP73(1), TSC2(9)	18747290	69	53	69	15	20	12	15	6	16	0	0.299	1.000	1.000
477	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	CPEB1(1), EGFR(4), ERBB4(4), ETS1(1), ETS2(1), FMN2(4), KRAS(4), MAP2K1(1), MAPK1(1), NOTCH1(1), NOTCH2(4), NOTCH3(7), NOTCH4(5), PIWIL1(2), PIWIL3(1), PIWIL4(7), RAF1(1), SOS1(4), SOS2(2), SPIRE1(3), SPIRE2(1)	15524113	59	53	59	17	28	13	12	1	5	0	0.389	1.000	1.000
478	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(4), CREBBP(6), DLL3(1), DTX3(4), DTX3L(2), DVL1(1), DVL2(4), EP300(3), HDAC2(1), HES1(2), JAG2(3), LFNG(2), MAML2(1), MFNG(1), NCOR2(6), NCSTN(3), NOTCH1(1), NOTCH2(4), NOTCH3(7), NOTCH4(5), NUMB(1), PSEN1(1), RBPJ(1), RBPJL(1), SNW1(2)	20995210	67	53	67	21	32	11	14	5	5	0	0.426	1.000	1.000
479	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(3), BCL2(1), BIRC2(1), BIRC3(1), CASP4(3), CASP6(1), CASP8(1), CHUK(2), DFFB(1), FADD(2), FASLG(1), GZMB(1), IKBKB(3), IRF1(1), IRF2(3), IRF3(1), IRF4(1), JUN(1), LTA(1), MAP2K4(3), MAP3K1(2), MAPK10(3), MDM2(1), MYC(1), NFKB1(2), NFKBIA(2), NFKBIB(1), PLEKHG5(1), PRF1(3), RELA(1), RIPK1(2), TNF(2), TNFRSF1A(1), TNFRSF21(2), TNFRSF25(1), TP73(1), TRAF1(1)	16875677	59	51	59	16	23	8	11	3	14	0	0.381	1.000	1.000
480	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(2), ADH1B(2), ADH5(1), ALDH3A1(1), ALDH3B2(1), AOC2(2), AOC3(1), AOX1(4), DCT(1), DDC(1), ECH1(1), ESCO1(2), ESCO2(2), GSTZ1(1), HEMK1(2), HGD(1), HPD(2), LCMT1(1), LCMT2(3), MAOA(2), MAOB(2), METTL2B(3), METTL6(1), PNPLA3(1), PRMT6(2), PRMT7(1), PRMT8(1), SH3GLB1(1), TH(2), TPO(9), TYR(4), WBSCR22(1)	17361228	61	51	61	13	28	10	13	1	9	0	0.0875	1.000	1.000
481	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP4A(1), INPP4B(2), INPP5A(1), INPPL1(3), ITPKB(1), OCRL(2), PIK3C2A(3), PIK3C2B(5), PIK3C2G(5), PIK3CA(7), PIK3CB(1), PIK3CG(2), PLCB1(7), PLCB2(2), PLCB3(2), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(5)	13395128	61	51	60	19	30	9	9	2	11	0	0.395	1.000	1.000
482	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(3), AKT3(1), BCR(1), BLNK(2), BTK(1), CD19(1), EPHB2(4), ITPKB(1), LYN(1), MAP2K1(1), MAP2K2(2), MAPK1(1), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIB(1), PIK3CA(7), PIK3CD(4), PIK3R1(2), PLCG2(5), PPP1R13B(5), RAF1(1), SHC1(2), SOS1(4), SOS2(2), SYK(1), VAV1(3)	15534272	64	50	63	15	36	9	8	2	9	0	0.116	1.000	1.000
483	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(2), CDA(1), DHODH(2), DPYD(3), ENTPD1(3), ENTPD6(1), NME1(1), NME6(1), NT5C1B(1), NT5C2(1), POLA2(1), POLD1(2), POLE(3), POLE2(2), POLE3(1), POLR1A(1), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), POLR3A(1), POLR3B(1), PRIM2(2), RFC5(2), RRM1(1), TK1(1), TK2(1), TXNRD1(1), TYMS(1), UCK2(1), UMPS(1), UPB1(1), UPRT(1)	24148757	55	49	55	18	23	8	10	4	10	0	0.509	1.000	1.000
484	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), AANAT(2), ACAT1(1), ACAT2(4), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), AOC2(2), AOC3(1), AOX1(4), ASMT(1), CYP1B1(1), DDC(1), ECHS1(1), EHHADH(9), HADH(1), HEMK1(2), KMO(1), KYNU(1), LCMT1(1), LCMT2(3), MAOA(2), MAOB(2), METTL2B(3), METTL6(1), NFX1(1), OGDHL(1), PRMT6(2), PRMT7(1), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WBSCR22(1)	17743092	60	48	60	18	26	11	13	2	8	0	0.353	1.000	1.000
485	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(2), ADH5(1), AGK(1), AGPAT1(2), AGPAT3(2), AGPAT4(1), AGPAT6(2), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), CEL(1), DAK(1), DGAT1(2), DGKE(2), DGKG(5), DGKH(1), DGKI(1), DGKZ(1), GK2(2), GLA(1), GLB1(2), GPAM(3), LCT(4), LIPA(2), LIPC(2), LPL(1), MGLL(1), PNLIP(1), PNLIPRP1(1), PNPLA3(1), PPAP2A(3), PPAP2C(3)	17556327	57	48	57	26	29	11	7	0	10	0	0.888	1.000	1.000
486	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	BDKRB2(3), CAV1(1), CHRNA1(2), FLT1(4), FLT4(6), KDR(9), NOS3(2), PDE3A(5), PRKACB(1), PRKAR2B(1), PRKG1(3), RYR2(25)	12433882	62	48	62	15	23	7	14	6	12	0	0.224	1.000	1.000
487	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), CHUK(2), EGF(4), EGFR(4), ETS1(1), ETS2(1), FOS(2), IKBKB(3), JUN(1), MAP2K1(1), MAP2K4(3), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK14(2), NFKB1(2), NFKBIA(2), PPP2CA(1), PRKCA(1), PRKCG(1), PRKCH(3), PRKCQ(2), RAF1(1), RELA(1), RIPK1(2), SP1(2), TNF(2), TNFRSF1A(1)	13947059	51	47	51	18	23	5	13	0	10	0	0.705	1.000	1.000
488	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CTLA4(1), EPHB2(4), FBXW7(1), GRAP2(2), ITPKB(1), LCK(3), LCP2(3), MAPK1(1), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIB(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), PLCG1(3), PTPRC(4), RAF1(1), RASGRP1(3), RASGRP2(2), RASGRP4(3), SOS1(4), SOS2(2), VAV1(3), ZAP70(1)	16867917	66	47	66	20	33	9	14	2	8	0	0.408	1.000	1.000
489	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR3(1), ITGA9(4), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), MAP2K1(1), MAPK1(1), PAK1(1), PDE3A(5), PIK3C2G(5), PIK3CA(7), PIK3CD(4), PIK3R1(2), RIPK3(2), SGCB(1), VASP(1)	14634300	53	46	52	18	31	12	5	2	3	0	0.555	1.000	1.000
490	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	FOS(2), FYN(1), JUN(1), LCK(3), MAP2K1(1), MAP2K4(3), MAP3K1(2), NFATC2(3), NFATC3(1), NFATC4(4), NFKB1(2), NFKBIA(2), PIK3CA(7), PIK3R1(2), PLCG1(3), PPP3CA(4), PRKCA(1), RAF1(1), RASA1(4), RELA(1), SHC1(2), SOS1(4), VAV1(3), ZAP70(1)	13988959	58	46	57	17	29	6	9	4	10	0	0.432	1.000	1.000
491	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(2), ADH5(1), AKR1C1(1), AKR1C2(1), AKR1C3(1), ALDH3A1(1), ALDH3B2(1), CYP1B1(1), CYP2C18(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP3A4(1), CYP3A43(1), CYP3A5(3), CYP3A7(1), DHDH(1), EPHX1(2), GSTA2(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTP1(2), GSTZ1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(2), UGT2B4(4), UGT2B7(2)	16963332	49	45	49	16	15	9	4	6	15	0	0.785	1.000	1.000
492	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ACAT1(1), ACAT2(4), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), AOC2(2), AOC3(1), AOX1(4), ASMT(1), CYP2A13(2), CYP2A6(1), CYP2A7(3), CYP2C18(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(1), DDC(1), ECHS1(1), EHHADH(9), KMO(1), KYNU(1), MAOA(2), MAOB(2), SDS(2), TDO2(1), TPH1(2)	16221304	56	45	56	15	21	8	11	4	12	0	0.299	1.000	1.000
493	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASS(2), ACAT1(1), ACAT2(4), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), BBOX1(1), DLST(2), DOT1L(4), ECHS1(1), EHHADH(9), EHMT1(2), EHMT2(2), HADH(1), HSD3B7(1), NSD1(6), OGDHL(1), PIPOX(1), PLOD1(2), PLOD2(1), PLOD3(1), RDH12(1), RDH13(1), RDH14(1), SETD1A(5), SETDB1(1), SHMT1(1), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(1), SUV39H2(1)	16906044	62	44	62	19	27	13	7	6	9	0	0.326	1.000	1.000
494	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(6), AR(2), ESR1(4), ESR2(1), ESRRA(1), HNF4A(1), NPM1(1), NR1D1(1), NR1H2(1), NR1H3(2), NR1I2(1), NR2C2(1), NR2F2(2), NR3C1(2), NR4A1(2), NR4A2(3), NR5A2(1), PGR(3), PPARA(2), PPARD(1), RARA(1), RARG(3), ROR1(4), RXRA(5), RXRB(2), RXRG(1)	12475862	54	44	54	14	26	12	5	4	7	0	0.257	1.000	1.000
495	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(3), AMY2A(2), AMY2B(1), ENPP3(1), G6PC(1), GAA(1), GANAB(1), GPI(2), GUSB(3), GYS1(2), GYS2(1), HK1(1), HK2(4), HK3(3), MGAM(5), PGM3(2), PYGB(1), PYGL(1), PYGM(5), SI(4), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A9(1), UGT2B15(1), UGT2B4(4)	19817810	58	44	58	22	29	8	4	5	12	0	0.746	1.000	1.000
496	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FOS(2), JUN(1), LYN(1), MAP2K1(1), MAP2K4(3), MAP3K1(2), MAPK1(1), NFATC2(3), NFATC3(1), NFATC4(4), PIK3CA(7), PIK3R1(2), PLA2G4A(5), PLCG1(3), PPP3CA(4), RAF1(1), SHC1(2), SOS1(4), SYK(1), VAV1(3)	12482902	52	43	51	13	27	8	7	2	8	0	0.223	1.000	1.000
497	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(2), CDA(1), DHODH(2), DPYD(3), ENTPD1(3), NME1(1), POLD1(2), POLE(3), POLG(4), POLQ(7), POLR2A(5), POLR2B(3), POLR2G(2), POLR2I(2), RRM1(1), TK1(1), TK2(1), TXNRD1(1), TYMS(1), UCK2(1), UMPS(1), UNG(1), UPB1(1)	17004868	49	43	49	14	23	11	6	2	7	0	0.290	1.000	1.000
498	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT1(2), AGPAT3(2), AGPAT4(1), CDIPT(1), CHAT(4), CHKA(1), CPT1B(3), DGKE(2), DGKG(5), DGKH(1), DGKZ(1), GNPAT(1), PAFAH2(1), PCYT1A(1), PCYT1B(1), PLA2G2E(1), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PLCB2(2), PLCG1(3), PLCG2(5), PPAP2A(3), PPAP2C(3)	15048453	54	42	54	18	32	9	7	0	6	0	0.307	1.000	1.000
499	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ACTG1(1), ARHGEF2(4), CDC42(2), CDH1(2), CLDN1(1), CTTN(2), EZR(2), FYN(1), ITGB1(1), KRT18(1), LY96(1), NCL(1), OCLN(1), PRKCA(1), ROCK1(3), ROCK2(3), TLR4(2), TLR5(1), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBA8(2), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB2B(1), TUBB6(1), TUBB8(3), WAS(1), WASL(1), YWHAZ(1)	14946945	51	42	51	18	18	7	15	3	8	0	0.798	1.000	1.000
500	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ACTG1(1), ARHGEF2(4), CDC42(2), CDH1(2), CLDN1(1), CTTN(2), EZR(2), FYN(1), ITGB1(1), KRT18(1), LY96(1), NCL(1), OCLN(1), PRKCA(1), ROCK1(3), ROCK2(3), TLR4(2), TLR5(1), TUBA1A(1), TUBA3C(3), TUBA3D(1), TUBA4A(1), TUBA8(2), TUBAL3(2), TUBB(1), TUBB1(1), TUBB2A(1), TUBB2B(1), TUBB6(1), TUBB8(3), WAS(1), WASL(1), YWHAZ(1)	14946945	51	42	51	18	18	7	15	3	8	0	0.798	1.000	1.000
501	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	CALR(3), CREBBP(6), EDN1(2), ELSPBP1(2), F2(1), GSK3B(2), HAND2(1), LIF(1), MAP2K1(1), MAPK1(1), MAPK14(2), MEF2C(1), MYH2(3), NFATC2(3), NFATC3(1), NFATC4(4), PIK3CA(7), PIK3R1(2), PPP3CA(4), PRKACB(1), PRKAR2B(1), RAF1(1), RPS6KB1(1)	14706669	51	42	50	13	27	4	9	4	7	0	0.211	1.000	1.000
502	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(5), CCND2(1), CSNK1E(2), DVL1(1), DVL2(4), FBXW2(1), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD5(1), FZD9(2), GSK3B(2), JUN(1), LDLR(1), MAPK10(3), MAPK9(1), MYC(1), PPP2R5C(1), PPP2R5E(1), PRKCA(1), PRKCG(1), PRKCH(3), PRKCQ(2), PRKCZ(1), PRKD1(2), SFRP4(1), TCF7(2), WNT1(2), WNT2(1), WNT4(1), WNT6(2)	15881767	54	41	54	15	20	14	8	4	8	0	0.321	1.000	1.000
503	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1D1(2), ARSD(1), CYP11B1(1), CYP11B2(5), HEMK1(2), HSD17B3(1), LCMT1(1), LCMT2(3), METTL2B(3), METTL6(1), PRMT6(2), PRMT7(1), PRMT8(1), SULT2B1(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(2), UGT2B4(4), UGT2B7(2), WBSCR22(1)	14350372	45	40	45	11	21	9	5	1	9	0	0.306	1.000	1.000
504	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(4), ATP4A(5), ATP5A1(1), ATP5B(3), ATP5C1(1), ATP5G3(1), ATP5L(1), ATP6AP1(1), ATP6V0A1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0D2(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), COX15(2), COX5A(2), COX5B(1), COX6B1(1), LHPP(1), NDUFA10(1), NDUFA5(1), NDUFV2(1), SDHA(3), SDHB(1), UQCRB(1)	16700317	45	40	45	18	21	8	8	3	5	0	0.770	1.000	1.000
505	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(3), CANX(1), CD4(1), CD8B(1), CTSB(2), HLA-B(1), HLA-DMA(1), HLA-DMB(2), HLA-DPB1(1), HLA-E(3), HLA-G(1), HSP90AA1(1), HSP90AB1(1), HSPA5(3), IFNA13(1), IFNA14(2), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(2), IFNA7(1), IFNA8(2), KIR2DL3(4), LTA(1), NFYA(1), PSME2(1), RFX5(1), RFXAP(1), TAP1(2)	13930299	47	40	47	18	16	8	9	4	10	0	0.816	1.000	1.000
506	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT2(3), AKT3(1), ARHGEF11(1), BCL2(1), CDC42(2), DLG4(2), GNA13(2), LPA(2), MAP2K4(3), MAP3K1(2), MAP3K5(2), NFKB1(2), NFKBIA(2), NFKBIB(1), PHKA2(2), PIK3CB(1), PLD1(2), PLD2(2), PLD3(3), PTK2(6), ROCK1(3), ROCK2(3)	14972068	48	40	48	14	20	6	6	3	13	0	0.469	1.000	1.000
507	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	CDC42(2), DLD(1), DUSP8(1), GAB1(3), IL1R1(3), JUN(1), MAP2K4(3), MAP3K1(2), MAP3K12(1), MAP3K2(1), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAP3K9(2), MAPK10(3), MAPK7(4), MAPK9(1), MYEF2(1), NFATC3(1), NR2C2(1), PAPPA(3), SHC1(2), TRAF6(1), ZAK(1)	14470343	45	40	45	15	20	3	9	3	10	0	0.621	1.000	1.000
508	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BCL2(1), CASP4(3), CASP6(1), CASP8(1), CRADD(1), DFFB(1), FADD(2), FASLG(1), IKBKE(1), LTA(1), MCL1(1), NFKB1(2), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(11), RIPK1(2), TNF(2), TNFRSF1A(1), TRAF1(1), TRAF6(1)	12902028	44	39	44	14	19	7	9	2	7	0	0.504	1.000	1.000
509	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), ALAS1(1), ALAS2(1), AMT(1), AOC2(2), AOC3(1), CBS(2), CHDH(2), CHKA(1), CTH(1), DAO(5), DLD(1), GARS(1), GATM(1), GCAT(1), GLDC(2), HSD3B7(1), MAOA(2), MAOB(2), PHGDH(2), PIPOX(1), PSAT1(2), RDH12(1), RDH13(1), RDH14(1), SARDH(3), SARS(1), SARS2(3), SDS(2), SHMT1(1), SHMT2(2), TARS(1), TARS2(1)	12741427	52	39	52	14	29	7	7	2	7	0	0.149	1.000	1.000
510	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(2), DDIT3(1), HSPB2(3), MAP2K4(3), MAP3K1(2), MAP3K5(2), MAP3K7(1), MAP3K9(2), MAPK14(2), MAPKAPK2(1), MAPKAPK5(2), MEF2A(3), MEF2C(1), MEF2D(1), MKNK1(1), MYC(1), PLA2G4A(5), RIPK1(2), RPS6KA5(1), SHC1(2), STAT1(2), TGFB2(2), TGFB3(2), TGFBR1(1)	11032671	45	39	45	11	21	5	10	1	8	0	0.254	1.000	1.000
511	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	26	BRCA1(4), CREBBP(6), EP300(3), ERCC3(3), ESR1(4), GRIP1(3), GTF2E1(1), HDAC2(1), HDAC3(1), HDAC4(2), MEF2C(1), NCOR2(6), PELP1(4), POLR2A(5)	14064054	44	38	44	10	22	4	9	0	9	0	0.113	1.000	1.000
512	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(3), ACACB(6), ACAT1(1), ACAT2(4), ACOT12(4), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), DLAT(1), DLD(1), GLO1(2), HAGHL(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), ME2(1), ME3(1), PC(4), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1)	13583621	45	38	45	17	23	6	7	3	6	0	0.630	1.000	1.000
513	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(4), AASS(2), ACAT1(1), ACAT2(4), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), BBOX1(1), DLST(2), DOT1L(4), ECHS1(1), EHHADH(9), EHMT1(2), EHMT2(2), PLOD1(2), PLOD2(1), PLOD3(1), SDS(2), SHMT1(1), SHMT2(2)	10729567	45	38	45	15	17	11	7	3	7	0	0.546	1.000	1.000
514	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(7), ATR(6), BRCA1(4), CCNB1(1), CHEK1(1), CHEK2(2), EP300(3), MDM2(1), MYT1(4), PRKDC(11), RPS6KA1(1), WEE1(2), YWHAH(1)	12356623	44	37	43	12	16	6	11	5	6	0	0.423	1.000	1.000
515	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(2), AGPAT1(2), AGPAT3(2), AGPAT4(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), CEL(1), DGAT1(2), DGKE(2), DGKG(5), DGKH(1), DGKZ(1), GLA(1), GLB1(2), LCT(4), LIPC(2), LPL(1), PNLIP(1), PNLIPRP1(1), PPAP2A(3), PPAP2C(3)	14469299	42	37	42	19	24	7	5	0	6	0	0.814	1.000	1.000
516	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADL(1), ACADS(1), ACADVL(1), ACAT1(1), ACAT2(4), ACOX1(2), ACOX3(1), ACSL1(1), ACSL5(1), ACSL6(1), ADH1A(2), ADH1B(2), ADH5(1), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), CPT1A(3), CPT1B(3), CPT1C(2), CYP4A11(1), CYP4A22(2), ECHS1(1), EHHADH(9), HADH(1), HADHB(1)	14367857	46	37	46	13	19	10	8	2	7	0	0.384	1.000	1.000
517	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(3), ABAT(1), ACADS(1), ACAT1(1), ACAT2(4), ACSM1(1), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(1), EHHADH(9), GAD1(3), GAD2(1), HADH(1), HMGCS1(2), HSD3B7(1), PDHA1(1), PDHA2(3), PDHB(1), RDH12(1), RDH13(1), RDH14(1)	12090847	45	37	45	17	20	11	7	2	5	0	0.668	1.000	1.000
518	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), ALAS1(1), ALAS2(1), AMT(1), AOC2(2), AOC3(1), CBS(2), CHDH(2), CHKA(1), CPT1B(3), CTH(1), DAO(5), DLD(1), GARS(1), GATM(1), GCAT(1), GLDC(2), MAOA(2), MAOB(2), PLCB2(2), PLCG1(3), PLCG2(5), SARDH(3), SARS(1), SHMT1(1), SHMT2(2), TARS(1)	12505561	50	36	50	12	29	6	8	1	6	0	0.0795	1.000	1.000
519	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), DLAT(1), DLD(1), ENO1(1), G6PC(1), GAPDHS(1), GPI(2), HK1(1), HK2(4), HK3(3), LDHA(1), LDHAL6B(1), PC(4), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PDHX(1), PFKL(1), PFKP(2), PGAM1(1), PGK2(2)	12318377	40	36	40	14	22	7	2	1	8	0	0.543	1.000	1.000
520	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), FOS(2), GNAI1(2), GNAS(7), GNB1(1), JUN(1), MAP2K1(1), NFATC2(3), NFATC3(1), NFATC4(4), PLCG1(3), PPP3CA(4), PRKACB(1), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(6)	10153159	42	36	40	10	23	5	8	1	5	0	0.201	1.000	1.000
521	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ADH1A(2), ADH1B(2), ADH5(1), ALDH1B1(1), ALDH3A1(1), ALDH3B2(1), ALDH7A1(1), ALDOB(2), DLAT(1), DLD(1), ENO1(1), G6PC(1), GAPDHS(1), GPI(2), HK1(1), HK2(4), HK3(3), LDHA(1), LDHAL6A(1), LDHAL6B(1), PDHA1(1), PDHA2(3), PDHB(1), PFKL(1), PFKP(2), PGAM1(1), PGK2(2), PGM3(2)	17096138	42	36	42	16	18	9	3	2	10	0	0.731	1.000	1.000
522	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS1(1), ALAS2(1), BLVRA(2), COX15(2), CP(2), CPOX(1), EPRS(3), FECH(1), FTMT(2), GUSB(3), HCCS(1), HMBS(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A5(1), UGT1A9(1), UGT2A1(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(2), UGT2B4(4), UGT2B7(2)	11956195	41	36	41	10	14	7	9	1	10	0	0.424	1.000	1.000
523	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(4), DGKI(1), RPL11(1), RPL13(1), RPL18(1), RPL22(1), RPL27(1), RPL3(1), RPL4(1), RPL5(1), RPL7A(1), RPS10(1), RPS23(1), RPS27A(1), RPS3(1), RPS4Y1(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(6), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), RPS9(1), SLC36A2(3), UBC(1)	14737617	42	36	42	10	21	5	7	1	8	0	0.176	1.000	1.000
524	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(5), ASAH1(1), CAMP(1), DLG4(2), EPHB2(4), GNAI1(2), ITPR1(6), ITPR2(3), ITPR3(8), KCNJ3(1), MAPK1(1), PTX3(1), RHO(1), RYR1(8)	13691268	44	36	44	10	23	8	4	1	8	0	0.104	1.000	1.000
525	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(3), BCL2(1), BIRC2(1), BIRC3(1), CASP6(1), CASP8(1), FADD(2), FASLG(1), GZMB(1), JUN(1), MAP2K4(3), MAP3K1(2), MAPK10(3), MCL1(1), MDM2(1), MYC(1), NFKB1(2), NFKBIA(2), PRF1(3), RELA(1), RIPK1(2), TNF(2), TNFRSF1A(1), TRAF1(1)	10858853	38	35	38	12	14	5	9	1	9	0	0.656	1.000	1.000
526	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	FPR1(1), GNA15(1), GNB1(1), MAP2K1(1), MAP2K2(2), MAP3K1(2), MAPK1(1), MAPK14(2), NCF2(1), NFATC2(3), NFATC3(1), NFATC4(4), NFKB1(2), NFKBIA(2), PAK1(1), PIK3C2G(5), PLCB1(7), PPP3CA(4), RAF1(1), RELA(1)	11489855	43	35	43	14	24	5	8	3	3	0	0.490	1.000	1.000
527	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(1), ACADS(1), ACAT1(1), ACAT2(4), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), AOX1(4), BCAT1(2), BCAT2(1), DBT(1), DLD(1), ECHS1(1), EHHADH(9), HADH(1), HADHB(1), HIBADH(1), HIBCH(4), HMGCS1(2), MCCC1(1), MUT(1), PCCB(2)	12926174	43	35	43	11	20	9	7	4	3	0	0.262	1.000	1.000
528	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(3), ACACB(6), ACAT1(1), ACAT2(4), ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), ECHS1(1), EHHADH(9), HIBCH(4), LDHA(1), LDHAL6A(1), LDHAL6B(1), MUT(1), PCCB(2), SUCLG1(2)	11640485	40	35	40	11	17	7	8	3	5	0	0.296	1.000	1.000
529	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(3), COL4A2(4), COL4A4(6), COL4A5(3), COL4A6(4), F10(3), F2(1), F5(4), F8(2), FGA(6), KLKB1(2), PROC(1), PROS1(2), SERPINC1(2)	13262023	43	35	42	12	18	9	8	2	6	0	0.410	1.000	1.000
530	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX5(2), CYP4F3(1), EPX(2), LPO(3), LTA4H(1), MPO(5), PLA2G2E(1), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PRDX1(1), PRDX2(1), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(9)	8350760	39	35	39	15	14	9	3	1	12	0	0.724	1.000	1.000
531	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(1), FOS(2), JUN(1), LYN(1), MAP2K1(1), MAP3K1(2), MAPK14(2), NFATC2(3), NFATC3(1), NFATC4(4), PLCG1(3), PPP3CA(4), PRKCA(1), RAF1(1), SHC1(2), SOS1(4), SYK(1), VAV1(3)	11067845	39	34	39	10	25	4	6	2	2	0	0.184	1.000	1.000
532	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(1), AZIN1(1), CBX3(1), CLOCK(1), CRY1(3), DNAJA1(1), EIF4G2(5), GFRA1(1), GSTP1(2), HSPA8(1), KLF9(1), NCKAP1(2), PER1(2), PER2(4), PPP2CB(1), PSMA4(2), SF3A3(1), TOB1(1), UCP3(2), ZFR(2)	10680501	35	34	35	10	22	2	6	2	3	0	0.254	1.000	1.000
533	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS2(3), ABAT(1), ACY3(1), ADSL(1), ADSS(2), ADSSL1(1), AGXT(2), ASNS(3), ASRGL1(1), ASS1(2), CAD(2), CRAT(2), DDO(1), DLAT(1), DLD(1), GAD1(3), GAD2(1), GPT(1), PC(4), PDHA1(1), PDHA2(3), PDHB(1)	11177313	38	34	38	15	21	7	7	1	2	0	0.678	1.000	1.000
534	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(2), ALPPL2(1), ASCC3(6), ATP13A2(1), DDX18(1), DDX4(1), DDX41(1), DDX47(1), DDX50(4), DDX56(1), EP400(2), ERCC2(2), ERCC3(3), FPGS(2), MOV10L1(1), NUDT5(1), PTS(1), RAD54B(3), SETX(3), SKIV2L2(1), SMARCA2(3), SMARCA5(1)	18603789	43	34	43	14	22	7	4	2	8	0	0.524	1.000	1.000
535	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALNT1(1), B3GALT1(1), B3GNT2(1), B4GALNT1(1), B4GALT2(1), B4GALT3(2), B4GALT6(2), FUT1(2), FUT3(1), FUT9(2), GBGT1(1), PIGB(1), PIGC(1), PIGL(2), PIGM(1), PIGN(2), PIGO(2), PIGQ(4), PIGS(2), PIGV(1), PIGZ(2), ST3GAL1(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(1), ST6GALNAC5(2), ST8SIA1(1)	14419753	40	34	40	13	13	6	12	2	7	0	0.667	1.000	1.000
536	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA2(1), POLD1(2), POLE(3), POLE2(2), POLE3(1), POLG(4), POLK(1), POLQ(7), PRIM2(2), REV1(4), REV3L(7), RFC5(2)	12181519	36	34	36	12	15	7	5	2	7	0	0.667	1.000	1.000
537	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTR3(1), CDC42(2), CFL1(1), CFL2(1), FLNA(4), FLNC(3), FSCN1(2), MYH2(3), MYLK2(1), PAK1(1), PAK3(3), PAK4(1), PAK6(1), PAK7(8), RHO(1), ROCK1(3), ROCK2(3), VASP(1), WASL(1)	14228555	42	34	42	16	20	6	10	1	5	0	0.723	1.000	1.000
538	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12B(2), ALOX15B(2), ALOX5(2), CYP2C18(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP4A11(1), CYP4A22(2), CYP4F3(1), DHRS4(1), EPHX2(1), LTA4H(1), PLA2G12B(1), PLA2G2E(1), PLA2G2F(3), PLA2G3(3), PLA2G4A(5), PLA2G6(1), PTGES(1), PTGS1(1), PTGS2(1), TBXAS1(1)	11793272	36	33	36	18	12	6	4	2	12	0	0.964	1.000	1.000
539	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(2), AKT2(3), AKT3(1), ITPKB(1), ITPR1(6), ITPR2(3), ITPR3(8), NFKB1(2), NFKBIA(2), NFKBIB(1), PHKA2(2), PIK3CB(1), PLD1(2), PLD2(2), PLD3(3)	13647504	39	32	39	13	18	8	5	2	6	0	0.541	1.000	1.000
540	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT2(1), G6PC(1), GAA(1), GALK1(2), GALT(1), GLA(1), GLB1(2), HK1(1), HK2(4), HK3(3), HSD3B7(1), LALBA(1), LCT(4), MGAM(5), PFKL(1), PFKP(2), PGM3(2), RDH12(1), RDH13(1), RDH14(1)	11348662	36	31	36	18	21	4	2	3	6	0	0.870	1.000	1.000
541	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), DLAT(1), DLD(1), DLST(2), FH(2), IDH2(4), IDH3G(1), PC(4), PDHA1(1), PDHA2(3), PDHB(1), PDHX(1), PDK2(1), PDK3(2), PDK4(1), SDHA(3), SDHB(1), SUCLG1(2)	8408916	34	31	34	12	16	5	4	4	5	0	0.506	1.000	1.000
542	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(6), DUSP1(1), EP300(3), IKBKB(3), IL1B(1), MAP3K7(1), MAPK14(2), MYD88(1), NFKB1(2), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(1), TLR2(1), TNF(2)	8714546	31	31	31	10	15	3	8	2	3	0	0.530	1.000	1.000
543	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(2), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ALDH3B2(1), ALDOB(2), DLAT(1), DLD(1), ENO1(1), G6PC(1), GPI(2), HK1(1), HK2(4), HK3(3), LDHA(1), PDHA1(1), PDHA2(3), PDHB(1), PFKP(2), PGAM1(1), PGM3(2)	14320385	35	30	35	16	17	7	1	2	8	0	0.850	1.000	1.000
544	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(2), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ALDH3B2(1), ALDOB(2), DLAT(1), DLD(1), ENO1(1), G6PC(1), GPI(2), HK1(1), HK2(4), HK3(3), LDHA(1), PDHA1(1), PDHA2(3), PDHB(1), PFKP(2), PGAM1(1), PGM3(2)	14320385	35	30	35	16	17	7	1	2	8	0	0.850	1.000	1.000
545	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOB(2), FPGT(2), GMPPA(3), HK1(1), HK2(4), HK3(3), HSD3B7(1), LHPP(1), MPI(1), MTMR1(1), MTMR6(2), PFKFB1(3), PFKFB2(1), PFKFB3(2), PFKL(1), PFKP(2), PGM2(1), PMM1(1), RDH12(1), RDH13(1), RDH14(1), SORD(1)	11115344	36	30	36	15	20	7	1	3	5	0	0.713	1.000	1.000
546	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(1), ADRA1B(1), ADRA1D(3), ADRB2(3), CHRM2(4), CHRM3(3), CHRM4(1), CHRM5(2), DRD2(1), DRD3(1), DRD5(2), HTR1A(1), HTR1B(1), HTR1D(1), HTR2C(4), HTR5A(1), HTR6(1), HTR7(5)	7442989	36	30	36	14	16	5	8	3	4	0	0.627	1.000	1.000
547	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(2), CCR2(2), CCR3(1), CCR7(4), CD4(1), CXCR3(1), CXCR4(1), IFNG(2), IFNGR1(2), IL12A(5), IL12B(1), IL12RB1(3), IL12RB2(4), IL18R1(1), IL4(1), IL4R(1), TGFB2(2), TGFB3(2)	5940840	37	30	37	11	13	6	13	1	4	0	0.447	1.000	1.000
548	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(6), EDN1(2), EDNRA(3), EDNRB(1), EGF(4), EGFR(4), FOS(2), JUN(1), MYC(1), NFKB1(2), PLCG1(3), PRKCA(1), RELA(1)	5976978	31	29	31	11	17	1	6	1	6	0	0.602	1.000	1.000
549	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(1), CD97(1), CRHR1(3), CRHR2(3), ELTD1(6), EMR1(2), EMR2(1), GLP1R(2), GLP2R(3), GPR64(1), LPHN1(5), LPHN2(2), LPHN3(4), VIPR2(1)	8256113	36	29	36	12	15	10	6	0	5	0	0.542	1.000	1.000
550	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	FUCA1(1), FUCA2(1), GLB1(2), GUSB(3), HEXA(1), HGSNAT(2), HPSE(1), HPSE2(1), HYAL1(1), IDUA(2), LCT(4), MAN2B2(2), MAN2C1(2), NAGLU(1), NEU1(3), NEU2(3), NEU3(2), SPAM1(3)	10426778	35	29	35	13	18	6	8	0	3	0	0.586	1.000	1.000
551	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(4), ATP6AP1(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V1A(2), ATP6V1B2(1), ATP6V1D(1), ATP6V1F(2), ATP7A(2), ATP7B(3), COX5A(2), COX5B(1), COX6B1(1), NDUFA10(1), NDUFA5(1), NDUFV2(1), SDHA(3), SDHB(1), SHMT1(1), UQCRB(1)	11283338	32	29	32	10	13	4	8	2	5	0	0.576	1.000	1.000
552	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(3), ACAT1(1), ACAT2(4), ADH5(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), DLAT(1), DLD(1), GLO1(2), HAGHL(1), LDHA(1), ME2(1), ME3(1), PC(4), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1)	10749373	34	29	34	14	19	4	5	1	5	0	0.753	1.000	1.000
553	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT2(1), G6PC(1), GAA(1), GALK1(2), GALT(1), GANAB(1), GLA(1), GLB1(2), HK1(1), HK2(4), HK3(3), LALBA(1), LCT(4), MGAM(5), PFKP(2), PGM3(2)	9588272	32	28	32	16	19	4	1	3	5	0	0.831	1.000	1.000
554	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(4), GABBR1(5), GPRC5A(1), GPRC5B(1), GRM1(3), GRM2(2), GRM3(5), GRM4(2), GRM5(3), GRM7(3), GRM8(4)	6086864	33	28	32	11	15	8	7	0	3	0	0.442	1.000	1.000
555	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(2), ACO1(1), ACO2(3), CLYBL(1), DLD(1), DLST(2), FH(2), IDH2(4), IDH3G(1), OGDHL(1), PC(4), PCK1(5), SDHA(3), SDHB(1), SUCLG1(2)	8484675	33	28	33	10	18	5	4	2	4	0	0.342	1.000	1.000
556	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), CAD(2), CPS1(6), EPRS(3), GAD1(3), GAD2(1), GFPT1(1), GFPT2(1), GLS(1), GLUD1(2), GLUD2(3), GLUL(1), GMPS(2), GPT(1), GSR(2), NADSYN1(1), NAGK(1), PPAT(1)	11587680	33	28	33	10	14	5	5	2	7	0	0.411	1.000	1.000
557	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(2), CREBBP(6), EP300(3), FADD(2), HDAC3(1), IKBKB(3), NFKB1(2), NFKBIA(2), RELA(1), RIPK1(2), TNF(2), TNFRSF1A(1), TRAF6(1)	6732620	28	28	28	11	15	4	6	0	3	0	0.680	1.000	1.000
558	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(4), EGFR(4), MAP2K1(1), MAPK1(1), PTPRB(6), RAF1(1), RASA1(4), SHC1(2), SOS1(4), SPRY2(1), SPRY3(1), SRC(1)	7377395	31	28	31	12	13	2	8	2	6	0	0.782	1.000	1.000
559	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	CDC42(2), CREB5(1), DUSP1(1), EEF2K(1), IL1R1(3), MAP2K4(3), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAPK1(1), MAPK14(2), MAPKAPK2(1), MAPKAPK5(2), MKNK1(1), MKNK2(1), MYEF2(1), NFKB1(2), NR2C2(1), TRAF6(1)	10066325	31	28	31	15	16	2	2	2	9	0	0.895	1.000	1.000
560	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADL(1), ACADS(1), ACAT1(1), ACAT2(4), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), AOX1(4), BCAT1(2), ECHS1(1), EHHADH(9), HADHB(1), HIBADH(1), MCCC1(1), MUT(1), PCCB(2), SDS(2)	10693893	35	28	35	13	15	8	6	2	4	0	0.757	1.000	1.000
561	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(1), ACADS(1), ACAT1(1), ACAT2(4), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ECHS1(1), EHHADH(9), GAD1(3), GAD2(1), PDHA1(1), PDHA2(3), PDHB(1), SDHB(1), SDS(2)	7562825	33	27	33	11	16	8	5	2	2	0	0.542	1.000	1.000
562	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(1), ALG13(2), ALG2(1), ALG3(1), ALG5(1), ALG6(1), ALG8(1), ALG9(2), B4GALT2(1), B4GALT3(2), DPAGT1(1), FUT8(1), GANAB(1), MAN1A1(1), MAN1A2(2), MAN1C1(1), MAN2A1(3), MGAT1(1), MGAT2(1), MGAT3(2), MGAT5(2), MGAT5B(2)	12594480	32	27	32	15	18	7	2	1	4	0	0.761	1.000	1.000
563	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BCL2(1), BIRC2(1), BIRC3(1), CASP6(1), CASP8(1), CFLAR(1), CHUK(2), DFFB(1), FADD(2), GAS2(1), LMNA(2), NFKB1(2), NFKBIA(2), RELA(1), RIPK1(2), SPTAN1(4), TNFRSF25(1)	9854953	29	26	29	10	12	7	3	1	6	0	0.657	1.000	1.000
564	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(3), ACADL(1), ACAT1(1), ACAT2(4), ALDH1A2(1), ALDH1B1(1), ALDH3A1(1), ECHS1(1), EHHADH(9), LDHA(1), MUT(1), PCCB(2), SDS(2), SUCLG1(2)	9727258	31	26	31	11	15	5	6	1	4	0	0.613	1.000	1.000
565	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA3(2), ANXA4(1), ANXA6(2), CYP11A1(1), EDN1(2), EDNRA(3), EDNRB(1), HPGD(2), PLA2G4A(5), PRL(2), PTGDR(1), PTGER2(1), PTGER4(1), PTGIR(2), PTGS1(1), PTGS2(1), TBXAS1(1)	6427300	29	26	29	12	11	8	5	1	4	0	0.805	1.000	1.000
566	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(7), BMPR1B(1), CCND2(1), ESR2(1), INHA(2), LHCGR(4), MLH1(1), MSH5(3), NCOR1(2), PGR(3), PTGER2(1), ZP2(1)	10070766	27	25	27	14	8	4	7	2	6	0	0.966	1.000	1.000
567	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(2), GRIN1(3), GRIN2A(2), GRIN2B(3), GRIN2D(1), NOS1(9), PPP3CA(4), PRKACB(1), PRKAR2B(1), PRKCA(1)	7556725	27	24	27	15	16	3	3	0	5	0	0.906	1.000	1.000
568	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACPP(4), ACPT(1), ALPI(1), ALPP(2), ALPPL2(1), CYP2A13(2), CYP2A6(1), CYP2A7(3), CYP2C18(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(1)	8745353	26	23	26	13	10	3	3	2	8	0	0.933	1.000	1.000
569	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(5), CDH1(2), CREBBP(6), EP300(3), MAP2K1(1), MAP3K7(1), SKIL(1), TGFB2(2), TGFB3(2), TGFBR1(1)	7548373	24	23	24	10	11	1	7	0	5	0	0.703	1.000	1.000
570	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(2), MAP3K1(2), MYC(1), NFATC2(3), NFKB1(2), NFKBIA(2), PLCG1(3), PPP3CA(4), PRKACB(1), PRKAR2B(1), RELA(1), VIPR2(1)	8071783	23	22	23	10	14	1	4	1	3	0	0.777	1.000	1.000
571	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ABAT(1), ADSL(1), ADSS(2), AGXT(2), ASNS(3), CAD(2), CRAT(2), DDO(1), GAD1(3), GAD2(1), GPT(1), PC(4)	7664034	23	21	23	12	13	3	5	1	1	0	0.892	1.000	1.000
572	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	21	F10(3), F13B(1), F2(1), F5(4), F8(2), FGA(6), LPA(2), SERPINB2(1), SERPINE1(1), VWF(5)	10615945	26	21	25	11	12	4	5	2	3	0	0.805	1.000	1.000
573	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(1), ANAPC5(1), ANAPC7(1), BTRC(1), CDC27(1), CUL1(1), CUL2(1), FBXW11(1), FBXW7(1), FZR1(2), SKP2(1), SMURF1(2), UBA1(3), UBE2D3(2), WWP2(2)	12212683	21	21	21	10	11	2	1	1	6	0	0.849	1.000	1.000
574	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(3), ACACB(6), FASN(10), MCAT(1), OXSM(2)	4815743	22	20	22	12	12	3	2	1	4	0	0.864	1.000	1.000
575	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CDC42(2), CHUK(2), MAP2K1(1), NFKB1(2), PIK3CA(7), PIK3R1(2), RAF1(1), RALBP1(1), RALGDS(1), RELA(1)	5762407	20	20	19	12	12	3	1	0	4	0	0.959	1.000	1.000
576	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), LCT(4), MAN2B2(2), MAN2C1(2), NEU1(3), NEU2(3), NEU3(2)	6114788	21	19	21	6	13	3	5	0	0	0	0.331	1.000	1.000
577	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(1), CMAS(1), CYB5R3(1), GFPT1(1), GFPT2(1), GNE(1), HEXA(1), HK1(1), HK2(4), HK3(3), LHPP(1), MTMR1(1), MTMR6(2), NAGK(1), PGM3(2)	8484062	22	19	22	15	10	3	2	3	4	0	0.979	1.000	1.000
578	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1QA(2), C1S(1), C2(1), C3(8), C4B(1), C5(3), C6(1), C7(1), C9(2), MASP2(1)	10352733	21	18	21	10	8	2	3	3	5	0	0.915	1.000	1.000
579	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(3), CARS2(1), EPRS(3), FARSB(1), GARS(1), HARS(1), HARS2(1), IARS(1), IARS2(2), MARS(3), MARS2(1), PARS2(1), SARS(1), SARS2(3), TARS(1), TARS2(1)	15877614	25	18	25	13	9	4	5	3	4	0	0.927	1.000	1.000
580	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BCL2(1), CASP8(1), FADD(2), MAP2K1(1), MAP2K4(3), MAP3K1(2), MAPK1(1), NFKB1(2), RAF1(1), RELA(1), RIPK1(2), TNFRSF1A(1)	5951797	18	17	18	10	9	2	2	0	5	0	0.941	1.000	1.000
581	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), GPI(2), H6PD(1), PFKL(1), PFKP(2), PGD(1), PGM3(2), PRPS1L1(1), PRPS2(1), TALDO1(1), TKTL1(2), TKTL2(3)	7153744	19	17	19	11	7	4	3	2	3	0	0.938	1.000	1.000
582	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), GPI(2), H6PD(1), PFKP(2), PGD(1), PGM3(2), PRPS1L1(1), PRPS2(1), TALDO1(1)	5904190	13	12	13	12	4	2	2	2	3	0	0.996	1.000	1.000
583	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD4(1), ICAM1(1), ITGAL(3), ITGB2(2), PTPRC(4)	3256581	11	11	11	5	8	1	2	0	0	0	0.737	1.000	1.000
584	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), GNAS(7), XPO1(1)	2811750	11	10	9	5	5	3	3	0	0	0	0.875	1.000	1.000
585	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAPK14(2), NFKB1(2), RELA(1), TNFSF13B(1), TRAF5(1), TRAF6(1)	4238242	10	10	10	6	9	1	0	0	0	0	0.824	1.000	1.000
586	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD4(1), FYN(1), LCK(3), PTPRC(4), ZAP70(1)	2674023	10	10	10	4	3	3	3	1	0	0	0.785	1.000	1.000
587	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	DFFB(1), ENDOG(1), GZMB(1), HMGB2(1), TOP2A(2), TOP2B(3)	3123031	9	9	9	5	3	2	2	2	0	0	0.921	1.000	1.000
588	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), IFNAR1(1), IFNB1(1), NFKB1(2), RELA(1), TNFRSF11A(1), TRAF6(1)	3169787	9	8	9	7	6	0	2	1	0	0	0.951	1.000	1.000
589	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), PC(4), PDHA1(1)	2671601	7	7	7	6	6	1	0	0	0	0	0.928	1.000	1.000
590	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(3), MTHFD1(1), MTHFD1L(1)	3743736	6	6	6	3	3	1	2	0	0	0	0.805	1.000	1.000
591	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD1(3), GAD2(1)	1733721	6	6	6	5	3	1	0	2	0	0	0.966	1.000	1.000
592	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(3), MTHFD1(1), MTHFD1L(1)	3926346	6	6	6	4	3	1	2	0	0	0	0.895	1.000	1.000
593	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(1), MTMR6(2), NFS1(1), TPK1(1)	1869867	6	6	6	5	3	2	0	1	0	0	0.967	1.000	1.000
594	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	MAP2K1(1), MAP2K2(2), MAPK1(1), NGFR(1), RAF1(1)	2444746	6	5	6	4	3	0	3	0	0	0	0.910	1.000	1.000
595	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), IL4(1), IL6(2), IL7(1)	1849957	5	5	5	3	1	2	2	0	0	0	0.900	1.000	1.000
596	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(1), ST3GAL5(1), ST6GALNAC2(1), ST8SIA1(1)	1624124	4	4	4	3	2	0	2	0	0	0	0.913	1.000	1.000
597	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(1), ALDH3A1(1), ALDH7A1(1), UGDH(1)	2493019	4	4	4	3	1	2	1	0	0	0	0.912	1.000	1.000
598	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(1), SNCA(1), UBE2L3(1)	1815180	4	4	4	3	2	1	1	0	0	0	0.895	1.000	1.000
599	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(1), CDK7(1), XPO1(1)	2539181	4	4	4	2	2	1	1	0	0	0	0.850	1.000	1.000
600	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1B1(1), ALDH3A1(1)	2329340	3	3	3	4	0	2	1	0	0	0	0.987	1.000	1.000
601	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), CD80(1), IL4(1)	1163127	3	3	3	2	0	1	2	0	0	0	0.946	1.000	1.000
602	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1B1(1), ALDH3A1(1)	2329340	3	3	3	4	0	2	1	0	0	0	0.987	1.000	1.000
603	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASS(2)	1381915	3	3	3	2	3	0	0	0	0	0	0.852	1.000	1.000
604	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(1), HSD17B3(1)	2373995	3	3	3	3	2	1	0	0	0	0	0.923	1.000	1.000
605	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1)	691339	1	1	1	2	0	1	0	0	0	0	0.988	1.000	1.000
606	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1)	1939112	1	1	1	4	0	0	1	0	0	0	0.998	1.000	1.000
607	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1)	1939112	1	1	1	4	0	0	1	0	0	0	0.998	1.000	1.000
608	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSB(1)	2539865	1	1	1	4	1	0	0	0	0	0	0.998	1.000	1.000
609	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(1)	1106116	1	1	1	2	0	1	0	0	0	0	0.987	1.000	1.000
610	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD4(1)	951949	1	1	1	2	0	1	0	0	0	0	0.989	1.000	1.000
611	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		491727	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3		765703	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		629422	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		442329	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		478914	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		340238	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
