		Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	256 (53%)	225	0.02528	0.297	0.14935	0.61	9.9999e-06	0.000568	0.00053999	0.0188	0.00015	0.00648	9.9999e-06	0.000568	9.9999e-06	0.000568	9.9999e-06	0.000568	9.9999e-06	0.000568	9.9999e-06	0.000568	0.88519	1	9.9999e-06	0.000568
KRAS	150 (31%)	331	0.89862	1	1	1	0.00184	0.0523	0.00227	0.0597	0.30989	0.822	0.11866	0.552	0.01027	0.17	9.9999e-06	0.000568	0.00155	0.0452	5.9999e-05	0.00282	0.44001	0.949	0.15648	0.62
KEAP1	84 (17%)	397	NA	NA	NA	NA	2e-05	0.00103	9.9999e-06	0.000568	0.00080999	0.026	0.36976	0.901	9.9999e-06	0.000568	9.9999e-06	0.000568	0.12142	0.558	0.00018	0.00748	0.054689	0.427	0.00081999	0.026
EGFR	67 (14%)	414	NA	NA	NA	NA	0.00039	0.0145	0.43368	0.947	0.00189	0.0523	0.02124	0.276	2e-05	0.00103	9.9999e-06	0.000568	0.0050499	0.105	0.03123	0.331	0.071419	0.467	0.00282	0.0708
STK11	77 (16%)	404	NA	NA	NA	NA	9.9999e-06	0.000568	0.00057999	0.0196	9.9999e-06	0.000568	0.095739	0.513	9.9999e-06	0.000568	9.9999e-06	0.000568	0.44516	0.952	0.01037	0.17	0.20763	0.703	0.11683	0.552
RBM10	33 (7%)	448	NA	NA	NA	NA	0.63954	1	0.056969	0.429	0.28432	0.802	0.45031	0.959	0.92319	1	0.77372	1	0.89274	1	0.053499	0.427	0.42868	0.943	0.65049	1
RB1	26 (5%)	455	NA	NA	NA	NA	0.43688	0.947	0.082939	0.482	0.18285	0.676	0.43239	0.947	0.072989	0.474	6.9999e-05	0.00315	0.15074	0.611	0.02763	0.304	0.057709	0.429	0.96018	1
ARID1A	30 (6%)	451	NA	NA	NA	NA	0.72037	1	0.7799	1	0.46694	0.97	0.70004	1	0.44026	0.949	0.87729	1	0.24228	0.75	0.077949	0.476	0.053059	0.427	0.11245	0.547
NF1	55 (11%)	426	0.63894	1	0.79157	1	0.53752	1	0.93066	1	0.061599	0.434	0.48073	0.98	0.062919	0.434	0.26059	0.778	0.109	0.54	0.35152	0.884	0.10718	0.54	0.088379	0.493
SMARCA4	38 (8%)	443	NA	NA	NA	NA	0.49164	0.989	9.9999e-06	0.000568	0.50875	1	0.10845	0.54	9.9999e-06	0.000568	9.9999e-06	0.000568	0.0053899	0.106	0.00036	0.0139	0.04939	0.427	5e-05	0.00245
BRAF	39 (8%)	442	0.14717	0.604	1	1	0.62967	1	0.078259	0.476	0.57357	1	0.89342	1	0.27251	0.787	0.38491	0.91	0.59052	1	0.03295	0.342	0.91861	1	0.51431	1
MGA	40 (8%)	441	NA	NA	NA	NA	0.26619	0.781	0.055749	0.427	0.72269	1	0.10313	0.532	0.00232	0.0597	0.15327	0.618	0.03108	0.331	0.065829	0.447	0.32769	0.855	0.080609	0.481
FTSJD1	24 (5%)	457	NA	NA	NA	NA	0.26767	0.783	0.34107	0.873	0.92977	1	0.38403	0.91	0.22325	0.728	0.28919	0.807	0.62638	1	0.66788	1	0.089489	0.495	0.19916	0.697
MET	21 (4%)	460	NA	NA	NA	NA	0.084879	0.483	0.73035	1	0.45724	0.962	0.26629	0.781	0.52149	1	0.62636	1	0.084939	0.483	0.20995	0.704	0.46961	0.97	0.16909	0.652
GAGE2A	8 (2%)	473	NA	NA	NA	NA	0.43631	0.947	0.59761	1	0.72064	1	0.4818	0.98	0.36057	0.891	0.5742	1	0.068889	0.456	0.73754	1	0.52522	1	0.31732	0.836
SETD2	30 (6%)	451	NA	NA	NA	NA	0.20842	0.703	0.37707	0.901	0.61059	1	0.68142	1	0.10151	0.529	0.22826	0.73	0.55451	1	0.9698	1	0.013	0.195	0.053989	0.427
U2AF1	11 (2%)	470	NA	NA	NA	NA	0.7171	1	0.84081	1	0.058019	0.429	0.68643	1	0.04818	0.427	0.12596	0.571	0.0086599	0.153	0.64754	1	0.098639	0.522	0.52908	1
ERBB2	11 (2%)	470	NA	NA	NA	NA	0.6833	1	0.096009	0.513	0.17183	0.655	1	1	0.51521	1	0.13871	0.59	0.73385	1	0.24076	0.749	0.50141	1	0.22223	0.728
CDKN2A	16 (3%)	465	NA	NA	NA	NA	0.76893	1	0.93648	1	0.82126	1	0.68859	1	0.060259	0.431	0.20706	0.703	1	1	0.85801	1	0.53084	1	0.91695	1
SRPX	14 (3%)	467	NA	NA	NA	NA	0.88566	1	0.79822	1	0.63789	1	0.03885	0.375	0.58625	1	0.91114	1	0.45633	0.962	0.5886	1	0.77482	1	0.30369	0.816
ATM	42 (9%)	439	NA	NA	NA	NA	0.00019	0.0076	0.00099999	0.0309	0.33247	0.859	0.93268	1	0.00206	0.0556	0.00047	0.0169	0.89021	1	0.053289	0.427	0.50928	1	0.91497	1
TCEAL5	13 (3%)	468	NA	NA	NA	NA	0.56384	1	0.66282	1	0.33079	0.859	0.92614	1	0.93557	1	0.86628	1	0.93333	1	0.62531	1	0.74635	1	0.57551	1
PPP3CA	12 (2%)	469	NA	NA	NA	NA	0.92618	1	0.30022	0.816	0.6398	1	0.80557	1	0.46985	0.97	0.01536	0.218	0.14184	0.596	0.24201	0.75	0.45806	0.962	0.2526	0.768
FCRLA	15 (3%)	466	NA	NA	NA	NA	0.17375	0.656	0.79946	1	0.84534	1	0.33236	0.859	0.8477	1	0.37459	0.901	1	1	0.84434	1	0.64254	1	0.19898	0.697
ARID2	24 (5%)	457	NA	NA	NA	NA	0.79171	1	0.6411	1	0.82648	1	1	1	0.13838	0.59	0.091809	0.498	0.079069	0.477	0.2861	0.803	0.12637	0.571	0.38464	0.91
APC	20 (4%)	461	NA	NA	NA	NA	0.88217	1	0.64246	1	0.88911	1	0.88421	1	0.086099	0.485	0.22159	0.728	0.063029	0.434	0.051599	0.427	0.82995	1	0.27646	0.79
ZEB1	32 (7%)	449	0.63899	1	1	1	0.65679	1	0.68935	1	0.76812	1	0.87703	1	0.46153	0.968	0.47634	0.976	0.50558	1	0.04397	0.413	0.96448	1	0.66404	1
SIP1	4 (1%)	477	0.11428	0.552	0.1195	0.552	0.066239	0.447	NA	NA	0.47073	0.97	1	1	1	1	0.97817	1	0.40751	0.921	0.14366	0.599	NA	NA	NA	NA
SLC4A3	18 (4%)	463	NA	NA	NA	NA	1	1	0.37392	0.901	0.17613	0.66	0.058339	0.429	0.12955	0.576	0.45369	0.959	0.14647	0.604	0.75179	1	0.34429	0.873	0.00348	0.0783
STK19	5 (1%)	476	NA	NA	NA	NA	0.66963	1	1	1	0.82294	1	0.58829	1	0.39037	0.913	0.97609	1	0.84824	1	0.65289	1	0.055469	0.427	0.828	1
NUDT11	5 (1%)	476	NA	NA	NA	NA	0.79967	1	1	1	0.62339	1	0.83231	1	0.82999	1	0.30672	0.816	0.066999	0.447	0.22971	0.73	1	1	0.14592	0.604
SLAMF9	12 (2%)	469	NA	NA	NA	NA	0.0089899	0.154	0.04039	0.386	0.93373	1	1	1	0.19952	0.697	0.60096	1	0.082369	0.482	0.01223	0.189	0.60555	1	0.62496	1
DNMT3A	19 (4%)	462	NA	NA	NA	NA	0.60314	1	0.48643	0.984	0.57637	1	0.2947	0.808	0.587	1	0.56283	1	0.33768	0.866	0.11051	0.545	0.0091299	0.154	0.0083099	0.152
CTNNB1	19 (4%)	462	NA	NA	NA	NA	0.43484	0.947	0.27798	0.79	0.03471	0.35	0.252	0.768	0.26982	0.784	0.40773	0.921	0.02688	0.302	0.79055	1	0.26358	0.781	0.76904	1
PTPRU	18 (4%)	463	NA	NA	NA	NA	0.01376	0.204	0.10793	0.54	0.10338	0.532	0.02607	0.302	0.01117	0.177	0.061039	0.434	0.00296	0.0727	0.0073899	0.14	1	1	0.18903	0.691
PIK3CA	28 (6%)	453	NA	NA	NA	NA	0.3678	0.899	0.30551	0.816	0.14965	0.61	0.13489	0.583	0.050399	0.427	0.02492	0.296	0.87445	1	0.56178	1	0.15942	0.622	0.16364	0.636
ZNF608	9 (2%)	472	NA	NA	NA	NA	0.18349	0.676	0.64067	1	0.23253	0.73	1	1	0.19944	0.697	0.0088899	0.154	0.50412	1	0.53315	1	0.56403	1	0.37374	0.901
STIM1	9 (2%)	472	NA	NA	NA	NA	0.01536	0.218	1	1	0.87554	1	0.86182	1	0.69889	1	0.26476	0.781	0.11865	0.552	0.19081	0.691	0.43532	0.947	0.88189	1
EMG1	5 (1%)	476	1	1	0.55757	1	0.6097	1	0.4007	0.92	0.75033	1	0.29457	0.808	0.074739	0.474	0.26167	0.779	0.21219	0.705	0.37285	0.901	NA	NA	NA	NA
PHKA1	12 (2%)	469	NA	NA	NA	NA	0.00124	0.0372	0.34498	0.873	0.69266	1	0.78127	1	0.13466	0.583	0.3553	0.886	0.39832	0.92	0.27905	0.791	0.41847	0.93	0.050529	0.427
PAK1	9 (2%)	472	NA	NA	NA	NA	0.35314	0.884	0.641	1	0.29212	0.808	0.88425	1	0.30038	0.816	0.2548	0.771	0.91231	1	0.84039	1	1	1	1	1
NRAS	3 (1%)	478	NA	NA	NA	NA	0.076529	0.476	NA	NA	NA	NA	NA	NA	0.1154	0.552	0.8951	1	0.30466	0.816	0.34982	0.883	NA	NA	NA	NA
G3BP1	8 (2%)	473	NA	NA	NA	NA	0.17578	0.66	0.69418	1	0.93069	1	0.33417	0.861	0.49884	0.999	0.83302	1	0.89812	1	0.81974	1	0.68714	1	0.65307	1
TRERF1	18 (4%)	463	NA	NA	NA	NA	0.15666	0.62	0.059819	0.431	0.29217	0.808	0.65425	1	0.01115	0.177	0.30692	0.816	0.069229	0.456	0.29827	0.816	0.55395	1	0.19549	0.697
CACNA1F	27 (6%)	454	NA	NA	NA	NA	1	1	0.9365	1	0.20179	0.7	0.81904	1	0.56145	1	0.10013	0.525	0.0078399	0.146	0.99155	1	0.58866	1	0.67689	1
NFE2L2	13 (3%)	468	NA	NA	NA	NA	0.60627	1	0.58074	1	0.27096	0.785	0.25016	0.768	0.074579	0.474	0.03832	0.375	1	1	0.19619	0.697	0.65732	1	0.75821	1
RPL5	8 (2%)	473	NA	NA	NA	NA	1	1	0.74267	1	0.90235	1	0.12937	0.576	0.73828	1	0.71892	1	0.42043	0.93	0.36749	0.899	0.46888	0.97	1	1
STRA8	8 (2%)	473	NA	NA	NA	NA	0.0047	0.0995	0.076609	0.476	0.0085099	0.153	0.02289	0.284	0.10499	0.535	0.03383	0.348	0.01281	0.195	0.11808	0.552	0.52768	1	0.23973	0.748
NLRP6	10 (2%)	471	NA	NA	NA	NA	0.1315	0.579	0.44338	0.952	0.02635	0.302	0.16513	0.639	0.73371	1	0.01871	0.253	0.13685	0.586	0.077839	0.476	0.56143	1	0.090709	0.495
FAM65C	14 (3%)	467	NA	NA	NA	NA	0.56676	1	0.83246	1	0.057299	0.429	0.054209	0.427	0.94493	1	0.68805	1	0.10736	0.54	0.48038	0.98	0.7957	1	0.13191	0.579
WDR66	14 (3%)	467	NA	NA	NA	NA	0.054689	0.427	0.0454	0.416	0.00342	0.0783	0.10398	0.532	0.55134	1	0.49114	0.989	0.15466	0.619	0.51081	1	0.12824	0.575	0.15878	0.622
RIT1	8 (2%)	473	NA	NA	NA	NA	0.03154	0.331	0.87706	1	0.36348	0.892	1	1	0.90723	1	0.17254	0.655	0.26903	0.784	1	1	0.49963	0.999	0.26993	0.784
TGFBR3	14 (3%)	467	NA	NA	NA	NA	0.60094	1	0.66477	1	0.79895	1	0.13942	0.59	0.3876	0.91	0.22793	0.73	0.0448	0.414	0.20349	0.7	0.19766	0.697	0.02236	0.284
CXCR7	10 (2%)	471	NA	NA	NA	NA	0.75064	1	0.78899	1	0.6551	1	0.19039	0.691	0.66946	1	0.65726	1	0.33719	0.866	0.65732	1	1	1	0.58956	1
GAN	10 (2%)	471	NA	NA	NA	NA	0.47858	0.979	0.90841	1	0.88849	1	0.83782	1	0.73176	1	0.40464	0.92	0.53748	1	0.79183	1	1	1	0.76728	1
TMEM49	5 (1%)	476	NA	NA	NA	NA	0.51656	1	0.2362	0.739	0.93405	1	0.090659	0.495	0.28104	0.795	0.21964	0.728	0.42629	0.94	0.46724	0.97	0.6174	1	0.40879	0.922
HSPA8	9 (2%)	472	NA	NA	NA	NA	0.15556	0.62	0.20643	0.703	0.42587	0.94	1	1	0.69915	1	0.22284	0.728	0.0053499	0.106	0.15722	0.62	0.29391	0.808	0.88583	1
CD244	12 (2%)	469	NA	NA	NA	NA	0.2604	0.778	0.66088	1	0.63024	1	0.77151	1	0.37807	0.901	0.26054	0.778	0.074709	0.474	0.01416	0.207	1	1	0.59408	1
KIF18B	4 (1%)	477	0.28927	0.807	0.39082	0.913	0.04607	0.418	NA	NA	0.36107	0.891	0.12576	0.571	0.4723	0.972	0.75345	1	1	1	0.45352	0.959	NA	NA	NA	NA
PDE6A	16 (3%)	465	NA	NA	NA	NA	0.32563	0.852	0.40504	0.92	1	1	0.11945	0.552	0.02464	0.296	0.02676	0.302	0.01848	0.253	0.02975	0.325	0.69514	1	0.574	1
CHRND	16 (3%)	465	NA	NA	NA	NA	0.15942	0.622	0.5346	1	0.13256	0.58	0.092989	0.502	0.4055	0.92	0.20444	0.701	0.3982	0.92	0.11798	0.552	0.60584	1	0.57245	1
KLK1	8 (2%)	473	NA	NA	NA	NA	0.03749	0.371	0.079449	0.477	0.56776	1	0.03853	0.375	0.55411	1	0.64823	1	0.19552	0.697	0.22497	0.73	0.20607	0.703	0.23037	0.73
KLHL5	14 (3%)	467	NA	NA	NA	NA	0.41796	0.93	0.93665	1	0.7584	1	0.086229	0.485	0.43326	0.947	0.7969	1	0.93903	1	0.65217	1	0.67441	1	0.76803	1
DSC2	20 (4%)	461	NA	NA	NA	NA	0.57815	1	0.075529	0.474	0.00317	0.0761	0.00444	0.0959	0.62672	1	0.8782	1	0.19134	0.691	0.34361	0.873	0.062439	0.434	0.1729	0.655
RNF160	15 (3%)	466	NA	NA	NA	NA	0.15486	0.619	0.10197	0.529	0.02172	0.279	0.12763	0.574	0.02104	0.276	0.41362	0.925	0.37587	0.901	0.20902	0.703	1	1	0.40402	0.92
AIFM1	12 (2%)	469	NA	NA	NA	NA	0.65569	1	0.32905	0.856	0.11926	0.552	0.065259	0.446	0.7623	1	0.49253	0.989	0.31716	0.836	0.085019	0.483	0.066729	0.447	0.85654	1
DOT1L	14 (3%)	467	NA	NA	NA	NA	0.65476	1	0.56302	1	0.062179	0.434	0.22808	0.73	0.78668	1	0.0070599	0.136	0.77357	1	0.082479	0.482	0.58528	1	0.29095	0.808
MCM9	3 (1%)	478	NA	NA	NA	NA	1	1	NA	NA	NA	NA	NA	NA	0.63861	1	0.76515	1	1	1	0.48435	0.983	NA	NA	NA	NA
NCKAP1L	19 (4%)	462	NA	NA	NA	NA	0.30321	0.816	0.24878	0.765	0.77014	1	0.62505	1	0.04414	0.413	0.21181	0.705	0.03595	0.359	0.059179	0.431	0.46268	0.968	0.7717	1
ESYT3	8 (2%)	473	NA	NA	NA	NA	0.84307	1	0.35233	0.884	0.23157	0.73	0.2608	0.778	0.40302	0.92	0.53722	1	0.46577	0.97	0.32502	0.852	0.25104	0.768	0.39746	0.92
MIA2	13 (3%)	468	NA	NA	NA	NA	0.01191	0.186	0.31532	0.835	0.95068	1	0.14136	0.596	0.30417	0.816	0.26575	0.781	0.87466	1	0.67912	1	1	1	0.76872	1
TUBB4	17 (4%)	464	NA	NA	NA	NA	0.57056	1	0.71844	1	0.66432	1	0.45176	0.959	0.74671	1	0.8065	1	0.80821	1	0.45108	0.959	0.5991	1	0.1167	0.552
ABHD12B	7 (1%)	474	NA	NA	NA	NA	0.22179	0.728	0.22871	0.73	0.62477	1	1	1	1	1	0.83554	1	0.082109	0.482	0.76291	1	0.76588	1	0.40097	0.92
ANTXR1	19 (4%)	462	NA	NA	NA	NA	0.77168	1	0.64086	1	0.94286	1	0.92032	1	0.69876	1	0.71862	1	0.48548	0.984	0.73398	1	0.72136	1	0.44516	0.952
FLCN	9 (2%)	472	NA	NA	NA	NA	0.36244	0.892	0.36118	0.891	0.23238	0.73	0.86085	1	0.83773	1	0.80233	1	0.60919	1	0.47638	0.976	0.30694	0.816	0.89327	1
ZNF556	12 (2%)	469	NA	NA	NA	NA	0.27786	0.79	0.59751	1	0.73142	1	0.88276	1	0.16993	0.653	0.18433	0.677	0.23248	0.73	0.58135	1	0.92354	1	0.051949	0.427
ASCL3	7 (1%)	474	NA	NA	NA	NA	0.3924	0.913	0.38282	0.91	0.34288	0.873	0.39158	0.913	0.27682	0.79	0.90731	1	0.04959	0.427	0.124	0.567	0.85209	1	0.50198	1
DSG3	33 (7%)	448	NA	NA	NA	NA	0.084489	0.483	0.38681	0.91	0.19747	0.697	0.85699	1	0.17275	0.655	0.70804	1	0.41978	0.93	0.40129	0.92	0.76504	1	0.41354	0.925
C5AR1	6 (1%)	475	NA	NA	NA	NA	0.64707	1	0.29241	0.808	0.30439	0.816	0.85029	1	0.22866	0.73	0.59044	1	0.11524	0.552	0.20109	0.7	1	1	0.11193	0.547
ASXL2	18 (4%)	463	NA	NA	NA	NA	0.54935	1	0.51064	1	0.53296	1	0.074029	0.474	0.41007	0.923	0.71644	1	0.37663	0.901	0.41987	0.93	0.14547	0.604	0.78152	1
DLX5	13 (3%)	468	NA	NA	NA	NA	0.75362	1	1	1	0.090149	0.495	0.32213	0.846	0.35906	0.891	0.71773	1	0.00412	0.0908	0.13495	0.583	0.15104	0.611	0.25959	0.778
ATAD2	14 (3%)	467	NA	NA	NA	NA	0.02475	0.296	0.02711	0.302	0.096929	0.516	0.49027	0.989	0.055199	0.427	0.27729	0.79	0.37412	0.901	0.01617	0.224	0.76094	1	0.40366	0.92
RAF1	6 (1%)	475	NA	NA	NA	NA	1	1	1	1	0.18104	0.674	0.074999	0.474	0.77692	1	0.55203	1	1	1	0.21133	0.705	0.04436	0.413	0.02461	0.296
A2M	20 (4%)	461	NA	NA	NA	NA	0.099079	0.522	0.62404	1	0.20362	0.7	0.38718	0.91	0.050409	0.427	0.051079	0.427	0.0052499	0.106	0.13545	0.583	0.20231	0.7	0.13172	0.579
SND1	16 (3%)	465	NA	NA	NA	NA	0.052119	0.427	0.059419	0.431	0.85244	1	0.0197	0.263	0.056399	0.429	0.02289	0.284	0.03426	0.349	0.088569	0.493	0.27381	0.789	0.01594	0.224
C7ORF36	6 (1%)	475	NA	NA	NA	NA	0.4514	0.959	0.55607	1	0.44346	0.952	0.85153	1	0.22903	0.73	0.35376	0.884	1	1	0.25348	0.769	1	1	1	1
HTRA1	10 (2%)	471	NA	NA	NA	NA	0.24768	0.764	0.18032	0.674	0.5053	1	0.68363	1	1	1	0.76342	1	0.84135	1	0.078499	0.476	1	1	0.75963	1
ADAMTS2	39 (8%)	442	NA	NA	NA	NA	0.19733	0.697	0.00339	0.0783	0.89834	1	0.1893	0.691	0.46828	0.97	0.81896	1	0.081799	0.482	0.050189	0.427	0.10888	0.54	0.79278	1
TAF1L	50 (10%)	431	0.63826	1	0.79358	1	0.3431	0.873	0.37219	0.901	0.44025	0.949	0.5067	1	0.04736	0.426	0.28563	0.803	0.03079	0.331	0.92385	1	0.76787	1	0.62652	1
PLEKHB2	6 (1%)	475	NA	NA	NA	NA	0.18225	0.676	0.87709	1	0.69889	1	0.41105	0.923	0.77631	1	0.35659	0.887	0.58143	1	0.11227	0.547	0.58513	1	0.1432	0.599
