Correlation between gene mutation status and selected clinical features
Overview
Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.

Summary

Testing the association between mutation status of 197 genes and 7 clinical features across 248 patients, 15 significant findings detected with Q value < 0.25.

  • PTEN mutation correlated to 'HISTOLOGICAL_TYPE' and 'RACE'.

  • PIK3R1 mutation correlated to 'HISTOLOGICAL_TYPE'.

  • TP53 mutation correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.

  • CTCF mutation correlated to 'HISTOLOGICAL_TYPE'.

  • ARID1A mutation correlated to 'Time to Death' and 'HISTOLOGICAL_TYPE'.

  • KRAS mutation correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.

  • CTNNB1 mutation correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.

  • PPP2R1A mutation correlated to 'HISTOLOGICAL_TYPE'.

  • ARID5B mutation correlated to 'RACE'.

  • WDR65 mutation correlated to 'YEARS_TO_BIRTH'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between mutation status of 197 genes and 7 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 15 significant findings detected.

Clinical
Features 		Time
to
Death 		YEARS
TO
BIRTH 		RADIATION
THERAPY 		HISTOLOGICAL
TYPE 		RESIDUAL
TUMOR 		RACE ETHNICITY
nMutated (%) nWild-Type logrank test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test
PTEN 161 (65%) 87 0.00681
(0.398) 		0.00753
(0.398) 		0.0728
(0.76) 		1e-05
(0.00276) 		0.0482
(0.71) 		0.00066
(0.0827) 		1
(1.00)
TP53 69 (28%) 179 0.00729
(0.398) 		5.85e-06
(0.00276) 		0.461
(0.831) 		1e-05
(0.00276) 		0.0482
(0.71) 		0.00937
(0.404) 		0.615
(0.91)
ARID1A 83 (33%) 165 0.00218
(0.214) 		0.00633
(0.398) 		0.403
(0.804) 		9e-05
(0.0207) 		0.254
(0.76) 		0.237
(0.76) 		1
(1.00)
KRAS 52 (21%) 196 0.127
(0.76) 		0.000317
(0.0506) 		1
(1.00) 		0.00033
(0.0506) 		0.488
(0.85) 		0.496
(0.85) 		0.585
(0.896)
CTNNB1 74 (30%) 174 0.626
(0.91) 		0.000515
(0.0711) 		0.565
(0.896) 		1e-05
(0.00276) 		0.531
(0.875) 		0.735
(0.972) 		1
(1.00)
PIK3R1 82 (33%) 166 0.397
(0.803) 		0.349
(0.773) 		0.576
(0.896) 		1e-05
(0.00276) 		0.951
(1.00) 		0.117
(0.76) 		0.348
(0.773)
CTCF 44 (18%) 204 0.213
(0.76) 		0.0368
(0.659) 		0.864
(1.00) 		0.00024
(0.0473) 		0.894
(1.00) 		0.775
(0.98) 		1
(1.00)
PPP2R1A 28 (11%) 220 0.595
(0.896) 		0.00531
(0.366) 		0.679
(0.946) 		0.00088
(0.101) 		1
(1.00) 		0.618
(0.91) 		0.39
(0.8)
ARID5B 29 (12%) 219 0.62
(0.91) 		0.884
(1.00) 		0.0651
(0.76) 		0.00993
(0.414) 		0.0886
(0.76) 		0.00233
(0.214) 		0.483
(0.848)
WDR65 6 (2%) 242 0.442
(0.825) 		0.000997
(0.106) 		0.417
(0.815) 		0.635
(0.91) 		1
(1.00) 		0.739
(0.972) 		1
(1.00)
FBXW7 38 (15%) 210 0.989
(1.00) 		0.998
(1.00) 		0.584
(0.896) 		0.003
(0.259) 		0.48
(0.846) 		0.765
(0.976) 		1
(1.00)
PIK3CA 131 (53%) 117 0.0197
(0.578) 		0.156
(0.76) 		1
(1.00) 		0.282
(0.76) 		0.153
(0.76) 		0.73
(0.972) 		1
(1.00)
ARHGAP35 36 (15%) 212 0.855
(1.00) 		0.914
(1.00) 		0.457
(0.829) 		0.725
(0.972) 		0.926
(1.00) 		0.195
(0.76) 		0.533
(0.875)
ZFHX3 44 (18%) 204 0.506
(0.855) 		0.744
(0.972) 		0.0849
(0.76) 		0.0679
(0.76) 		0.438
(0.821) 		0.101
(0.76) 		0.187
(0.76)
SPOP 21 (8%) 227 0.308
(0.771) 		0.451
(0.829) 		0.811
(1.00) 		0.84
(1.00) 		0.569
(0.896) 		0.727
(0.972) 		0.37
(0.785)
FGFR2 31 (12%) 217 0.375
(0.786) 		0.983
(1.00) 		0.84
(1.00) 		0.776
(0.98) 		0.362
(0.777) 		0.616
(0.91) 		1
(1.00)
TCP11L2 14 (6%) 234 0.107
(0.76) 		0.988
(1.00) 		0.581
(0.896) 		0.172
(0.76) 		0.228
(0.76) 		0.0901
(0.76) 		0.284
(0.76)
VPS11 11 (4%) 237 0.557
(0.887) 		0.653
(0.923) 		0.541
(0.875) 		1
(1.00) 		1
(1.00) 		0.317
(0.773) 		1
(1.00)
MAX 9 (4%) 239 0.739
(0.972) 		0.271
(0.76) 		0.491
(0.85) 		0.457
(0.829) 		0.35
(0.773) 		0.408
(0.809) 		1
(1.00)
SOX17 7 (3%) 241 0.399
(0.803) 		0.452
(0.829) 		1
(1.00) 		0.428
(0.815) 		0.674
(0.942) 		0.0635
(0.76) 		1
(1.00)
CCND1 14 (6%) 234 0.525
(0.875) 		0.0652
(0.76) 		0.393
(0.803) 		0.172
(0.76) 		0.257
(0.76) 		0.755
(0.972) 		0.284
(0.76)
NRAS 9 (4%) 239 0.188
(0.76) 		0.785
(0.985) 		0.491
(0.85) 		1
(1.00) 		1
(1.00) 		0.042
(0.71) 		0.19
(0.76)
EP300 21 (8%) 227 0.327
(0.773) 		0.0984
(0.76) 		0.484
(0.848) 		0.0641
(0.76) 		1
(1.00) 		0.551
(0.884) 		0.0689
(0.76)
KLHL8 12 (5%) 236 0.17
(0.76) 		0.289
(0.76) 		0.765
(0.976) 		0.288
(0.76) 		0.212
(0.76) 		0.464
(0.834) 		0.214
(0.76)
ALG8 11 (4%) 237 0.782
(0.982) 		0.479
(0.845) 		0.751
(0.972) 		0.352
(0.773) 		0.591
(0.896) 		0.349
(0.773) 		0.0225
(0.597)
GNPTAB 20 (8%) 228 0.0944
(0.76) 		0.324
(0.773) 		0.146
(0.76) 		0.269
(0.76) 		0.575
(0.896) 		0.478
(0.845) 		0.328
(0.773)
SIN3A 21 (8%) 227 0.247
(0.76) 		0.159
(0.76) 		0.157
(0.76) 		0.279
(0.76) 		0.89
(1.00) 		0.0957
(0.76) 		1
(1.00)
NFE2L2 14 (6%) 234 0.551
(0.884) 		0.0928
(0.76) 		0.265
(0.76) 		0.17
(0.76) 		0.85
(1.00) 		0.498
(0.85) 		1
(1.00)
ZNF471 15 (6%) 233 0.959
(1.00) 		0.0355
(0.648) 		0.181
(0.76) 		0.14
(0.76) 		0.36
(0.777) 		0.0604
(0.76) 		0.284
(0.76)
MORC4 20 (8%) 228 0.0692
(0.76) 		0.0146
(0.48) 		0.811
(1.00) 		0.268
(0.76) 		1
(1.00) 		0.731
(0.972) 		0.328
(0.773)
SELP 10 (4%) 238 0.623
(0.91) 		0.314
(0.773) 		0.331
(0.773) 		0.335
(0.773) 		0.248
(0.76) 		0.0854
(0.76) 		0.19
(0.76)
RBMX 12 (5%) 236 0.811
(1.00) 		0.455
(0.829) 		0.765
(0.976) 		0.288
(0.76) 		0.0778
(0.76) 		0.193
(0.76) 		1
(1.00)
FAT1 40 (16%) 208 0.0146
(0.48) 		0.875
(1.00) 		0.859
(1.00) 		0.0434
(0.71) 		0.772
(0.98) 		0.404
(0.806) 		0.176
(0.76)
MARK3 11 (4%) 237 0.544
(0.875) 		0.0516
(0.728) 		0.751
(0.972) 		0.353
(0.773) 		0.198
(0.76) 		0.324
(0.773) 		0.164
(0.76)
SOS1 12 (5%) 236 0.195
(0.76) 		0.108
(0.76) 		1
(1.00) 		0.29
(0.76) 		0.835
(1.00) 		0.893
(1.00) 		1
(1.00)
RBBP6 22 (9%) 226 0.242
(0.76) 		0.988
(1.00) 		0.652
(0.923) 		0.0449
(0.71) 		0.497
(0.85) 		0.28
(0.76) 		1
(1.00)
ZNF263 7 (3%) 241 0.298
(0.771) 		0.0566
(0.76) 		1
(1.00) 		0.427
(0.815) 		0.201
(0.76) 		0.352
(0.773) 		0.0852
(0.76)
INTS7 8 (3%) 240 0.197
(0.76) 		0.536
(0.875) 		0.714
(0.972) 		0.436
(0.821) 		0.53
(0.875) 		0.176
(0.76) 		0.139
(0.76)
L1TD1 16 (6%) 232 0.139
(0.76) 		0.348
(0.773) 		0.424
(0.815) 		0.12
(0.76) 		0.878
(1.00) 		0.321
(0.773) 		0.284
(0.76)
NAT1 7 (3%) 241 0.815
(1.00) 		0.983
(1.00) 		1
(1.00) 		0.429
(0.815) 		0.466
(0.834) 		0.197
(0.76) 		1
(1.00)
JAKMIP2 12 (5%) 236 0.422
(0.815) 		0.0301
(0.638) 		0.543
(0.875) 		0.288
(0.76) 		0.259
(0.76) 		0.0291
(0.638) 		0.19
(0.76)
ING1 12 (5%) 236 0.232
(0.76) 		0.956
(1.00) 		0.765
(0.976) 		0.289
(0.76) 		1
(1.00) 		0.894
(1.00) 		1
(1.00)
CCDC6 6 (2%) 242 0.482
(0.848) 		0.749
(0.972) 		1
(1.00) 		0.362
(0.777) 		1
(1.00) 		0.53
(0.875) 		1
(1.00)
ZNF781 10 (4%) 238 0.299
(0.771) 		0.112
(0.76) 		0.0965
(0.76) 		0.336
(0.773) 		0.478
(0.845) 		0.712
(0.972) 		0.164
(0.76)
MKI67 29 (12%) 219 0.11
(0.76) 		0.499
(0.85) 		0.31
(0.771) 		0.0105
(0.414) 		0.232
(0.76) 		0.186
(0.76) 		0.465
(0.834)
EIF2S2 9 (4%) 239 0.26
(0.76) 		0.384
(0.791) 		0.491
(0.85) 		0.461
(0.831) 		0.337
(0.773) 		0.228
(0.76) 		0.19
(0.76)
BCOR 30 (12%) 218 0.0315
(0.638) 		0.0735
(0.76) 		0.428
(0.815) 		0.00849
(0.402) 		0.36
(0.777) 		0.0287
(0.638) 		1
(1.00)
RASA1 21 (8%) 227 0.063
(0.76) 		0.852
(1.00) 		0.241
(0.76) 		0.568
(0.896) 		1
(1.00) 		0.0739
(0.76) 		0.0611
(0.76)
DNER 18 (7%) 230 0.374
(0.786) 		0.0325
(0.638) 		1
(1.00) 		0.416
(0.815) 		0.626
(0.91) 		0.0991
(0.76) 		0.284
(0.76)
C9ORF23 9 (4%) 239 0.312
(0.772) 		0.588
(0.896) 		1
(1.00) 		0.457
(0.829) 		1
(1.00) 		1
(1.00) 		1
(1.00)
CUX1 21 (8%) 227 0.244
(0.76) 		0.114
(0.76) 		0.816
(1.00) 		0.275
(0.76) 		0.806
(1.00) 		0.237
(0.76) 		1
(1.00)
CDK17 14 (6%) 234 0.464
(0.834) 		0.0852
(0.76) 		0.265
(0.76) 		0.128
(0.76) 		0.271
(0.76) 		0.36
(0.777) 		0.262
(0.76)
USP28 10 (4%) 238 0.132
(0.76) 		0.502
(0.853) 		0.331
(0.773) 		0.333
(0.773) 		0.777
(0.98) 		0.352
(0.773) 		1
(1.00)
MSH6 17 (7%) 231 0.27
(0.76) 		0.124
(0.76) 		1
(1.00) 		0.492
(0.85) 		0.6
(0.896) 		0.573
(0.896) 		0.262
(0.76)
WDR45 11 (4%) 237 0.716
(0.972) 		0.551
(0.884) 		1
(1.00) 		0.352
(0.773) 		0.528
(0.875) 		0.0414
(0.71) 		1
(1.00)
C14ORF166B 9 (4%) 239 0.261
(0.76) 		0.589
(0.896) 		0.0284
(0.638) 		0.455
(0.829) 		1
(1.00) 		0.0846
(0.76) 		1
(1.00)
ATM 29 (12%) 219 0.0211
(0.588) 		0.265
(0.76) 		0.31
(0.771) 		0.0757
(0.76) 		0.904
(1.00) 		0.218
(0.76) 		0.447
(0.829)
RAE1 11 (4%) 237 0.199
(0.76) 		0.729
(0.972) 		0.0584
(0.76) 		0.744
(0.972) 		1
(1.00) 		0.315
(0.773) 		1
(1.00)
ZNF485 9 (4%) 239 0.955
(1.00) 		0.361
(0.777) 		0.16
(0.76) 		0.453
(0.829) 		0.0703
(0.76) 		0.227
(0.76) 		0.214
(0.76)
POLE 27 (11%) 221 0.362
(0.777) 		0.552
(0.884) 		0.291
(0.76) 		0.127
(0.76) 		0.398
(0.803) 		0.373
(0.786) 		0.429
(0.815)
AHCYL1 6 (2%) 242 0.316
(0.773) 		0.0311
(0.638) 		1
(1.00) 		0.633
(0.91) 		0.401
(0.803) 		0.171
(0.76) 		0.0852
(0.76)
ZNF334 17 (7%) 231 0.538
(0.875) 		0.00468
(0.339) 		0.608
(0.904) 		0.807
(1.00) 		0.601
(0.896) 		0.73
(0.972) 		0.307
(0.771)
SACS 26 (10%) 222 0.12
(0.76) 		0.855
(1.00) 		0.528
(0.875) 		0.118
(0.76) 		0.626
(0.91) 		0.0491
(0.71) 		0.00718
(0.398)
MSH4 15 (6%) 233 0.108
(0.76) 		0.155
(0.76) 		0.582
(0.896) 		0.138
(0.76) 		0.63
(0.91) 		0.069
(0.76) 		0.262
(0.76)
SLC26A8 12 (5%) 236 0.214
(0.76) 		0.0329
(0.638) 		0.543
(0.875) 		0.289
(0.76) 		0.685
(0.949) 		0.399
(0.803) 		0.238
(0.76)
KIF20B 21 (8%) 227 0.0809
(0.76) 		0.142
(0.76) 		0.484
(0.848) 		0.0646
(0.76) 		0.905
(1.00) 		0.553
(0.884) 		0.307
(0.771)
RRAS2 4 (2%) 244 0.497
(0.85) 		0.0213
(0.588) 		0.628
(0.91) 		1
(1.00) 		0.427
(0.815) 		1
(1.00) 		1
(1.00)
CTNND1 19 (8%) 229 0.766
(0.976) 		0.411
(0.812) 		1
(1.00) 		0.426
(0.815) 		0.381
(0.79) 		0.507
(0.856) 		1
(1.00)
NFE2L3 12 (5%) 236 0.561
(0.892) 		0.781
(0.98) 		0.368
(0.785) 		0.22
(0.76) 		0.408
(0.809) 		0.204
(0.76) 		1
(1.00)
FAM65B 16 (6%) 232 0.115
(0.76) 		0.049
(0.71) 		0.791
(0.989) 		0.476
(0.845) 		0.863
(1.00) 		0.247
(0.76) 		0.262
(0.76)
RNF43 12 (5%) 236 0.16
(0.76) 		0.671
(0.941) 		0.0357
(0.648) 		0.289
(0.76) 		0.64
(0.911) 		0.295
(0.767) 		1
(1.00)
MRPL47 6 (2%) 242 0.417
(0.815) 		0.92
(1.00) 		0.417
(0.815) 		1
(1.00) 		0.464
(0.834) 		1
(1.00) 		0.112
(0.76)
TIGD4 13 (5%) 235 0.176
(0.76) 		0.0517
(0.728) 		0.772
(0.98) 		0.301
(0.771) 		0.593
(0.896) 		0.476
(0.845) 		0.262
(0.76)
FILIP1 16 (6%) 232 0.0888
(0.76) 		0.596
(0.896) 		0.598
(0.896) 		0.477
(0.845) 		0.591
(0.896) 		0.804
(1.00) 		0.214
(0.76)
SLC1A3 12 (5%) 236 0.603
(0.899) 		0.755
(0.972) 		1
(1.00) 		1
(1.00) 		0.637
(0.911) 		0.00772
(0.398) 		1
(1.00)
UFSP2 11 (4%) 237 0.167
(0.76) 		1
(1.00) 		1
(1.00) 		0.353
(0.773) 		0.687
(0.949) 		0.754
(0.972) 		0.19
(0.76)
WBP4 8 (3%) 240 0.359
(0.777) 		0.133
(0.76) 		0.264
(0.76) 		0.437
(0.821) 		1
(1.00) 		1
(1.00) 		1
(1.00)
TRIM59 9 (4%) 239 0.271
(0.76) 		0.876
(1.00) 		0.491
(0.85) 		0.456
(0.829) 		1
(1.00) 		0.0396
(0.701) 		1
(1.00)
RSBN1L 12 (5%) 236 0.127
(0.76) 		0.291
(0.76) 		0.543
(0.875) 		0.753
(0.972) 		0.158
(0.76) 		0.00331
(0.268) 		0.238
(0.76)
SERHL2 6 (2%) 242 0.248
(0.76) 		0.699
(0.964) 		0.198
(0.76) 		0.633
(0.91) 		1
(1.00) 		1
(1.00) 		1
(1.00)
OR52I2 8 (3%) 240 0.774
(0.98) 		0.679
(0.946) 		1
(1.00) 		0.156
(0.76) 		0.778
(0.98) 		0.351
(0.773) 		1
(1.00)
SGK1 13 (5%) 235 0.592
(0.896) 		0.426
(0.815) 		1
(1.00) 		0.575
(0.896) 		0.0469
(0.71) 		0.299
(0.771) 		1
(1.00)
LNX2 14 (6%) 234 0.141
(0.76) 		0.843
(1.00) 		0.0889
(0.76) 		0.169
(0.76) 		0.764
(0.976) 		0.182
(0.76) 		0.284
(0.76)
ALPK2 19 (8%) 229 0.0473
(0.71) 		0.233
(0.76) 		0.334
(0.773) 		0.429
(0.815) 		0.239
(0.76) 		0.126
(0.76) 		0.307
(0.771)
REV3L 20 (8%) 228 0.0774
(0.76) 		0.503
(0.853) 		0.335
(0.773) 		0.0681
(0.76) 		0.916
(1.00) 		0.144
(0.76) 		0.328
(0.773)
CAB39L 8 (3%) 240 0.253
(0.76) 		0.789
(0.988) 		0.264
(0.76) 		0.438
(0.821) 		1
(1.00) 		0.00914
(0.404) 		1
(1.00)
ERBB3 17 (7%) 231 0.133
(0.76) 		0.598
(0.896) 		0.796
(0.994) 		0.492
(0.85) 		0.274
(0.76) 		0.0885
(0.76) 		1
(1.00)
INPP4B 12 (5%) 236 0.519
(0.87) 		0.178
(0.76) 		0.0044
(0.337) 		0.29
(0.76) 		0.166
(0.76) 		0.142
(0.76) 		0.238
(0.76)
C1ORF100 9 (4%) 239 0.151
(0.76) 		0.139
(0.76) 		1
(1.00) 		0.458
(0.829) 		0.466
(0.834) 		0.354
(0.773) 		0.112
(0.76)
IL20 7 (3%) 241 0.255
(0.76) 		0.169
(0.76) 		0.712
(0.972) 		0.428
(0.815) 		0.103
(0.76) 		0.0128
(0.464) 		0.112
(0.76)
SLC44A3 6 (2%) 242 0.305
(0.771) 		0.0571
(0.76) 		1
(1.00) 		0.635
(0.91) 		0.606
(0.902) 		0.425
(0.815) 		1
(1.00)
TAP1 8 (3%) 240 0.646
(0.917) 		0.942
(1.00) 		0.714
(0.972) 		0.437
(0.821) 		1
(1.00) 		0.398
(0.803) 		1
(1.00)
RHBDD3 4 (2%) 244 0.392
(0.803) 		0.128
(0.76) 		0.628
(0.91) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00)
BRDT 14 (6%) 234 0.146
(0.76) 		0.0842
(0.76) 		0.0889
(0.76) 		0.172
(0.76) 		0.634
(0.91) 		0.185
(0.76) 		0.238
(0.76)
RB1 20 (8%) 228 0.221
(0.76) 		0.124
(0.76) 		0.146
(0.76) 		0.0682
(0.76) 		0.867
(1.00) 		0.0768
(0.76) 		1
(1.00)
MFAP5 9 (4%) 239 0.263
(0.76) 		0.0104
(0.414) 		1
(1.00) 		1
(1.00) 		0.528
(0.875) 		0.565
(0.896) 		0.164
(0.76)
NAA15 14 (6%) 234 0.366
(0.782) 		0.991
(1.00) 		0.777
(0.98) 		0.586
(0.896) 		0.761
(0.976) 		0.232
(0.76) 		0.238
(0.76)
ZRANB3 7 (3%) 241 0.22
(0.76) 		0.499
(0.85) 		0.712
(0.972) 		1
(1.00) 		1
(1.00) 		0.198
(0.76) 		1
(1.00)
SLC34A3 6 (2%) 242 0.388
(0.798) 		0.108
(0.76) 		0.673
(0.941) 		0.632
(0.91) 		1
(1.00) 		0.228
(0.76) 		1
(1.00)
MLH3 17 (7%) 231 0.45
(0.829) 		0.00875
(0.402) 		0.608
(0.904) 		0.494
(0.85) 		0.239
(0.76) 		0.171
(0.76) 		0.307
(0.771)
CCDC147 15 (6%) 233 0.153
(0.76) 		0.0312
(0.638) 		0.181
(0.76) 		0.472
(0.841) 		0.595
(0.896) 		0.276
(0.76) 		0.238
(0.76)
ZNF662 13 (5%) 235 0.126
(0.76) 		0.493
(0.85) 		0.772
(0.98) 		0.577
(0.896) 		0.637
(0.911) 		0.275
(0.76) 		0.214
(0.76)
PSMC4 11 (4%) 237 0.223
(0.76) 		0.831
(1.00) 		1
(1.00) 		0.352
(0.773) 		0.851
(1.00) 		0.148
(0.76) 		1
(1.00)
CCDC160 11 (4%) 237 0.165
(0.76) 		0.204
(0.76) 		0.751
(0.972) 		0.35
(0.773) 		0.833
(1.00) 		0.4
(0.803) 		1
(1.00)
PPIL4 11 (4%) 237 0.227
(0.76) 		0.86
(1.00) 		0.541
(0.875) 		0.746
(0.972) 		0.592
(0.896) 		1
(1.00) 		0.214
(0.76)
CCDC144A 18 (7%) 230 0.393
(0.803) 		0.128
(0.76) 		0.212
(0.76) 		0.661
(0.932) 		0.295
(0.767) 		0.0357
(0.648) 		0.307
(0.771)
TUBGCP6 20 (8%) 228 0.495
(0.85) 		0.328
(0.773) 		0.631
(0.91) 		0.0678
(0.76) 		0.379
(0.789) 		0.22
(0.76) 		1
(1.00)
TTC39C 7 (3%) 241 0.283
(0.76) 		0.344
(0.773) 		0.0487
(0.71) 		0.424
(0.815) 		1
(1.00) 		0.599
(0.896) 		1
(1.00)
COL8A1 10 (4%) 238 0.245
(0.76) 		0.864
(1.00) 		1
(1.00) 		0.335
(0.773) 		0.47
(0.839) 		0.46
(0.831) 		0.112
(0.76)
PER3 12 (5%) 236 0.172
(0.76) 		0.521
(0.873) 		0.543
(0.875) 		0.289
(0.76) 		1
(1.00) 		0.557
(0.887) 		1
(1.00)
MGA 26 (10%) 222 0.683
(0.949) 		0.67
(0.941) 		0.834
(1.00) 		0.35
(0.773) 		0.149
(0.76) 		0.351
(0.773) 		0.349
(0.773)
GPRASP1 21 (8%) 227 0.241
(0.76) 		0.17
(0.76) 		0.816
(1.00) 		0.278
(0.76) 		0.587
(0.896) 		0.675
(0.942) 		0.328
(0.773)
PPM1D 11 (4%) 237 0.195
(0.76) 		0.351
(0.773) 		0.0584
(0.76) 		0.353
(0.773) 		0.585
(0.896) 		0.251
(0.76) 		0.19
(0.76)
ZNF674 14 (6%) 234 0.0977
(0.76) 		0.101
(0.76) 		0.581
(0.896) 		0.585
(0.896) 		0.515
(0.865) 		0.192
(0.76) 		1
(1.00)
LIMK2 12 (5%) 236 0.241
(0.76) 		0.781
(0.98) 		0.543
(0.875) 		0.751
(0.972) 		0.687
(0.949) 		0.316
(0.773) 		0.214
(0.76)
ZNF606 16 (6%) 232 0.354
(0.773) 		0.446
(0.829) 		0.18
(0.76) 		0.121
(0.76) 		0.495
(0.85) 		0.129
(0.76) 		0.0336
(0.638)
SFRP4 8 (3%) 240 0.218
(0.76) 		0.124
(0.76) 		0.714
(0.972) 		0.439
(0.822) 		0.338
(0.773) 		0.341
(0.773) 		0.139
(0.76)
TXNRD1 8 (3%) 240 0.141
(0.76) 		0.632
(0.91) 		0.264
(0.76) 		0.436
(0.821) 		0.352
(0.773) 		0.824
(1.00) 		1
(1.00)
LETMD1 6 (2%) 242 0.225
(0.76) 		0.888
(1.00) 		1
(1.00) 		0.634
(0.91) 		0.054
(0.752) 		0.114
(0.76) 		0.112
(0.76)
ZNF721 13 (5%) 235 0.187
(0.76) 		0.0494
(0.71) 		0.383
(0.79) 		0.302
(0.771) 		0.632
(0.91) 		0.183
(0.76) 		0.238
(0.76)
RASSF9 9 (4%) 239 0.244
(0.76) 		0.0134
(0.475) 		0.16
(0.76) 		0.456
(0.829) 		0.586
(0.896) 		0.168
(0.76) 		0.164
(0.76)
AGXT2 11 (4%) 237 0.667
(0.938) 		0.168
(0.76) 		0.751
(0.972) 		0.352
(0.773) 		0.631
(0.91) 		0.51
(0.86) 		0.19
(0.76)
MECOM 12 (5%) 236 0.12
(0.76) 		0.0117
(0.435) 		0.543
(0.875) 		0.289
(0.76) 		1
(1.00) 		0.809
(1.00) 		1
(1.00)
ATP6V1C2 12 (5%) 236 0.148
(0.76) 		0.033
(0.638) 		1
(1.00) 		0.291
(0.76) 		0.835
(1.00) 		0.184
(0.76) 		1
(1.00)
DYM 10 (4%) 238 0.279
(0.76) 		0.732
(0.972) 		0.749
(0.972) 		0.741
(0.972) 		1
(1.00) 		0.579
(0.896) 		1
(1.00)
TAB3 18 (7%) 230 0.0852
(0.76) 		0.0402
(0.702) 		0.458
(0.829) 		0.0876
(0.76) 		0.259
(0.76) 		0.0316
(0.638) 		0.37
(0.785)
ZNF649 14 (6%) 234 0.138
(0.76) 		0.185
(0.76) 		0.265
(0.76) 		0.17
(0.76) 		0.764
(0.976) 		0.907
(1.00) 		0.238
(0.76)
FN1 24 (10%) 224 0.217
(0.76) 		0.779
(0.98) 		0.825
(1.00) 		0.0224
(0.597) 		0.375
(0.786) 		0.778
(0.98) 		0.429
(0.815)
CCDC150 11 (4%) 237 0.291
(0.76) 		0.8
(0.998) 		0.751
(0.972) 		0.743
(0.972) 		0.85
(1.00) 		0.876
(1.00) 		1
(1.00)
KIF21A 15 (6%) 233 0.13
(0.76) 		0.329
(0.773) 		0.0564
(0.76) 		0.141
(0.76) 		0.591
(0.896) 		0.378
(0.789) 		0.262
(0.76)
BHLHB9 8 (3%) 240 0.243
(0.76) 		0.398
(0.803) 		1
(1.00) 		0.437
(0.821) 		0.733
(0.972) 		0.402
(0.803) 		1
(1.00)
EXOSC9 10 (4%) 238 0.264
(0.76) 		0.78
(0.98) 		0.331
(0.773) 		0.334
(0.773) 		0.589
(0.896) 		0.406
(0.808) 		0.19
(0.76)
ZKSCAN1 7 (3%) 241 0.357
(0.777) 		0.968
(1.00) 		0.712
(0.972) 		1
(1.00) 		0.732
(0.972) 		0.597
(0.896) 		1
(1.00)
OR8B8 7 (3%) 241 0.302
(0.771) 		0.0145
(0.48) 		0.265
(0.76) 		0.425
(0.815) 		0.398
(0.803) 		0.286
(0.76) 		0.139
(0.76)
SENP7 12 (5%) 236 0.429
(0.815) 		0.609
(0.904) 		0.543
(0.875) 		0.288
(0.76) 		0.685
(0.949) 		0.554
(0.884) 		1
(1.00)
NRIP1 13 (5%) 235 0.456
(0.829) 		0.117
(0.76) 		0.383
(0.79) 		0.577
(0.896) 		0.407
(0.808) 		0.357
(0.777) 		1
(1.00)
MCTP1 13 (5%) 235 0.153
(0.76) 		0.0153
(0.481) 		1
(1.00) 		0.575
(0.896) 		0.636
(0.91) 		0.478
(0.845) 		0.238
(0.76)
CCDC146 14 (6%) 234 0.15
(0.76) 		0.033
(0.638) 		0.0889
(0.76) 		0.171
(0.76) 		0.636
(0.91) 		0.231
(0.76) 		0.238
(0.76)
ZNF620 9 (4%) 239 0.262
(0.76) 		0.0254
(0.638) 		0.491
(0.85) 		0.458
(0.829) 		0.731
(0.972) 		0.709
(0.972) 		1
(1.00)
PTPN12 10 (4%) 238 0.766
(0.976) 		0.829
(1.00) 		0.331
(0.773) 		0.336
(0.773) 		0.587
(0.896) 		0.231
(0.76) 		0.19
(0.76)
RIOK3 9 (4%) 239 0.262
(0.76) 		0.364
(0.779) 		0.16
(0.76) 		0.457
(0.829) 		1
(1.00) 		0.409
(0.809) 		1
(1.00)
CASP8 17 (7%) 231 0.926
(1.00) 		0.748
(0.972) 		0.791
(0.989) 		0.488
(0.85) 		0.525
(0.875) 		0.0283
(0.638) 		0.0465
(0.71)
GFAP 6 (2%) 242 0.373
(0.786) 		0.142
(0.76) 		1
(1.00) 		0.633
(0.91) 		0.324
(0.773) 		0.672
(0.941) 		0.0852
(0.76)
OMA1 10 (4%) 238 0.265
(0.76) 		0.09
(0.76) 		0.0965
(0.76) 		0.335
(0.773) 		0.529
(0.875) 		0.278
(0.76) 		0.164
(0.76)
DENND3 15 (6%) 233 0.365
(0.779) 		0.123
(0.76) 		0.423
(0.815) 		0.472
(0.841) 		0.878
(1.00) 		0.158
(0.76) 		0.0336
(0.638)
CHEK2 12 (5%) 236 0.65
(0.922) 		0.015
(0.48) 		0.219
(0.76) 		0.753
(0.972) 		0.134
(0.76) 		0.399
(0.803) 		0.19
(0.76)
ZMYM2 17 (7%) 231 0.323
(0.773) 		0.0287
(0.638) 		0.302
(0.771) 		0.0994
(0.76) 		0.662
(0.932) 		0.277
(0.76) 		1
(1.00)
EPC2 5 (2%) 243 0.296
(0.768) 		0.639
(0.911) 		0.654
(0.923) 		0.618
(0.91) 		1
(1.00) 		0.17
(0.76) 		1
(1.00)
DEPDC1B 11 (4%) 237 0.872
(1.00) 		0.592
(0.896) 		1
(1.00) 		0.744
(0.972) 		0.158
(0.76) 		0.0481
(0.71) 		1
(1.00)
C3AR1 7 (3%) 241 0.195
(0.76) 		0.802
(0.999) 		1
(1.00) 		0.43
(0.815) 		0.531
(0.875) 		0.126
(0.76) 		0.139
(0.76)
STK3 10 (4%) 238 0.202
(0.76) 		0.0478
(0.71) 		0.506
(0.855) 		0.335
(0.773) 		1
(1.00) 		0.125
(0.76) 		1
(1.00)
FOXJ3 10 (4%) 238 0.221
(0.76) 		0.512
(0.862) 		0.749
(0.972) 		0.335
(0.773) 		0.64
(0.911) 		0.085
(0.76) 		0.214
(0.76)
EPS8 12 (5%) 236 0.741
(0.972) 		0.124
(0.76) 		1
(1.00) 		0.753
(0.972) 		0.684
(0.949) 		0.399
(0.803) 		0.238
(0.76)
ZNF385B 7 (3%) 241 0.359
(0.777) 		0.204
(0.76) 		0.265
(0.76) 		0.426
(0.815) 		1
(1.00) 		0.5
(0.85) 		1
(1.00)
EFCAB4B 11 (4%) 237 0.155
(0.76) 		0.0206
(0.588) 		0.751
(0.972) 		0.352
(0.773) 		0.338
(0.773) 		0.0239
(0.622) 		0.19
(0.76)
NPRL2 5 (2%) 243 0.946
(1.00) 		0.816
(1.00) 		0.654
(0.923) 		0.619
(0.91) 		0.246
(0.76) 		1
(1.00) 		1
(1.00)
ATF6 14 (6%) 234 0.117
(0.76) 		0.309
(0.771) 		1
(1.00) 		0.582
(0.896) 		0.633
(0.91) 		0.334
(0.773) 		0.238
(0.76)
LIMA1 8 (3%) 240 0.213
(0.76) 		0.888
(1.00) 		0.714
(0.972) 		0.438
(0.821) 		1
(1.00) 		0.659
(0.929) 		1
(1.00)
PPIG 16 (6%) 232 0.162
(0.76) 		0.0726
(0.76) 		0.598
(0.896) 		0.121
(0.76) 		0.904
(1.00) 		0.932
(1.00) 		0.284
(0.76)
ZNF774 10 (4%) 238 0.213
(0.76) 		0.581
(0.896) 		0.749
(0.972) 		0.744
(0.972) 		0.587
(0.896) 		0.709
(0.972) 		0.164
(0.76)
MUTED 7 (3%) 241 0.307
(0.771) 		0.748
(0.972) 		0.265
(0.76) 		0.426
(0.815) 		1
(1.00) 		0.0943
(0.76) 		1
(1.00)
TPX2 6 (2%) 242 0.378
(0.789) 		0.0114
(0.435) 		1
(1.00) 		0.631
(0.91) 		0.135
(0.76) 		0.673
(0.941) 		0.0852
(0.76)
PARG 9 (4%) 239 0.244
(0.76) 		0.554
(0.884) 		1
(1.00) 		0.457
(0.829) 		1
(1.00) 		0.709
(0.972) 		1
(1.00)
PSMD3 11 (4%) 237 0.16
(0.76) 		0.373
(0.786) 		1
(1.00) 		0.746
(0.972) 		1
(1.00) 		0.402
(0.803) 		1
(1.00)
STRN3 12 (5%) 236 0.208
(0.76) 		0.28
(0.76) 		0.543
(0.875) 		0.752
(0.972) 		0.591
(0.896) 		0.343
(0.773) 		0.238
(0.76)
MLL4 30 (12%) 218 0.0308
(0.638) 		0.245
(0.76) 		0.693
(0.956) 		0.0443
(0.71) 		0.571
(0.896) 		0.293
(0.764) 		0.5
(0.85)
MSN 15 (6%) 233 0.34
(0.773) 		0.273
(0.76) 		1
(1.00) 		0.597
(0.896) 		0.485
(0.848) 		0.0177
(0.542) 		0.238
(0.76)
MAPK8 11 (4%) 237 0.159
(0.76) 		0.775
(0.98) 		0.221
(0.76) 		0.353
(0.773) 		0.308
(0.771) 		0.318
(0.773) 		1
(1.00)
RBL2 12 (5%) 236 0.527
(0.875) 		0.211
(0.76) 		1
(1.00) 		0.287
(0.76) 		0.154
(0.76) 		0.149
(0.76) 		0.238
(0.76)
PDGFRA 12 (5%) 236 0.14
(0.76) 		0.181
(0.76) 		0.543
(0.875) 		0.289
(0.76) 		1
(1.00) 		0.478
(0.845) 		1
(1.00)
TMEM62 9 (4%) 239 0.309
(0.771) 		0.506
(0.855) 		0.491
(0.85) 		0.454
(0.829) 		0.588
(0.896) 		0.351
(0.773) 		0.19
(0.76)
RG9MTD3 8 (3%) 240 0.756
(0.972) 		0.72
(0.972) 		0.264
(0.76) 		0.684
(0.949) 		0.352
(0.773) 		0.565
(0.896) 		1
(1.00)
KANK4 11 (4%) 237 0.899
(1.00) 		0.043
(0.71) 		0.751
(0.972) 		0.748
(0.972) 		1
(1.00) 		0.511
(0.861) 		1
(1.00)
MYOM1 23 (9%) 225 0.53
(0.875) 		0.228
(0.76) 		1
(1.00) 		0.848
(1.00) 		0.441
(0.825) 		0.106
(0.76) 		0.37
(0.785)
MORC3 10 (4%) 238 0.202
(0.76) 		0.108
(0.76) 		1
(1.00) 		0.741
(0.972) 		0.398
(0.803) 		0.754
(0.972) 		1
(1.00)
CCDC82 12 (5%) 236 0.179
(0.76) 		0.769
(0.98) 		0.543
(0.875) 		0.288
(0.76) 		0.593
(0.896) 		0.876
(1.00) 		0.19
(0.76)
B3GALT5 4 (2%) 244 0.532
(0.875) 		0.104
(0.76) 		0.3
(0.771) 		1
(1.00) 		1
(1.00) 		0.374
(0.786) 		1
(1.00)
NOC3L 11 (4%) 237 0.186
(0.76) 		0.379
(0.789) 		0.221
(0.76) 		0.352
(0.773) 		0.642
(0.913) 		0.0971
(0.76) 		0.19
(0.76)
NSUN4 6 (2%) 242 0.377
(0.789) 		0.721
(0.972) 		0.417
(0.815) 		1
(1.00) 		0.61
(0.904) 		0.227
(0.76) 		0.112
(0.76)
ASXL2 14 (6%) 234 0.122
(0.76) 		0.381
(0.79) 		0.581
(0.896) 		0.587
(0.896) 		0.204
(0.76) 		0.522
(0.874) 		0.214
(0.76)
CHD4 35 (14%) 213 0.829
(1.00) 		0.425
(0.815) 		0.345
(0.773) 		0.452
(0.829) 		1
(1.00) 		0.735
(0.972) 		1
(1.00)
FCN1 7 (3%) 241 0.878
(1.00) 		0.82
(1.00) 		1
(1.00) 		0.428
(0.815) 		1
(1.00) 		0.124
(0.76) 		1
(1.00)
NIPA2 8 (3%) 240 0.311
(0.772) 		0.986
(1.00) 		0.714
(0.972) 		1
(1.00) 		1
(1.00) 		0.0338
(0.638) 		1
(1.00)
C14ORF118 13 (5%) 235 0.198
(0.76) 		0.00808
(0.398) 		0.14
(0.76) 		0.304
(0.771) 		0.727
(0.972) 		0.388
(0.798) 		0.214
(0.76)
THAP5 6 (2%) 242 0.347
(0.773) 		0.115
(0.76) 		0.0875
(0.76) 		0.634
(0.91) 		1
(1.00) 		0.288
(0.76) 		1
(1.00)
ZNF611 12 (5%) 236 0.732
(0.972) 		0.244
(0.76) 		1
(1.00) 		0.288
(0.76) 		0.165
(0.76) 		0.207
(0.76) 		0.238
(0.76)
ZCCHC18 6 (2%) 242 0.379
(0.789) 		0.943
(1.00) 		0.0875
(0.76) 		0.633
(0.91) 		1
(1.00) 		0.534
(0.875) 		1
(1.00)
PRKCE 9 (4%) 239 0.201
(0.76) 		0.996
(1.00) 		0.729
(0.972) 		0.457
(0.829) 		1
(1.00) 		0.457
(0.829) 		1
(1.00)
BMP2K 13 (5%) 235 0.178
(0.76) 		0.904
(1.00) 		0.383
(0.79) 		0.3
(0.771) 		0.686
(0.949) 		0.73
(0.972) 		0.238
(0.76)
PRPF38B 11 (4%) 237 0.245
(0.76) 		0.397
(0.803) 		0.751
(0.972) 		0.353
(0.773) 		0.638
(0.911) 		0.753
(0.972) 		0.214
(0.76)
LGMN 7 (3%) 241 0.28
(0.76) 		0.987
(1.00) 		0.712
(0.972) 		0.425
(0.815) 		0.281
(0.76) 		1
(1.00) 		1
(1.00)
SSH2 12 (5%) 236 0.213
(0.76) 		0.208
(0.76) 		0.543
(0.875) 		0.752
(0.972) 		0.592
(0.896) 		0.00801
(0.398) 		0.0278
(0.638)
EMR1 11 (4%) 237 0.212
(0.76) 		0.13
(0.76) 		0.221
(0.76) 		0.354
(0.773) 		0.584
(0.896) 		0.755
(0.972) 		0.19
(0.76)
OR5AK2 5 (2%) 243 0.261
(0.76) 		0.21
(0.76) 		0.654
(0.923) 		0.623
(0.91) 		0.326
(0.773) 		0.0684
(0.76) 		0.0852
(0.76)
C1ORF101 12 (5%) 236 0.198
(0.76) 		0.0191
(0.571) 		0.543
(0.875) 		0.288
(0.76) 		0.728
(0.972) 		0.149
(0.76) 		0.238
(0.76)
ZNF534 9 (4%) 239 0.288
(0.76) 		0.317
(0.773) 		0.491
(0.85) 		0.455
(0.829) 		0.585
(0.896) 		0.272
(0.76) 		0.19
(0.76)
FAM122A 6 (2%) 242 0.896
(1.00) 		0.991
(1.00) 		1
(1.00) 		0.631
(0.91) 		0.282
(0.76) 		0.532
(0.875) 		1
(1.00)
'PTEN MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S1.  Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
PTEN MUTATED 159 1 1
PTEN WILD-TYPE 41 3 43

Figure S1.  Get High-res Image Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'PTEN MUTATION STATUS' versus 'RACE'

P value = 0.00066 (Fisher's exact test), Q value = 0.083

Table S2.  Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #6: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER WHITE
ALL 3 13 25 7 194
PTEN MUTATED 3 10 7 4 133
PTEN WILD-TYPE 0 3 18 3 61

Figure S2.  Get High-res Image Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #6: 'RACE'

'PIK3R1 MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S3.  Gene #2: 'PIK3R1 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
PIK3R1 MUTATED 79 1 2
PIK3R1 WILD-TYPE 121 3 42

Figure S3.  Get High-res Image Gene #2: 'PIK3R1 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'TP53 MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 5.85e-06 (Wilcoxon-test), Q value = 0.0028

Table S4.  Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
TP53 MUTATED 69 67.9 (9.4)
TP53 WILD-TYPE 179 61.3 (11.2)

Figure S4.  Get High-res Image Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'TP53 MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S5.  Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
TP53 MUTATED 27 3 39
TP53 WILD-TYPE 173 1 5

Figure S5.  Get High-res Image Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'CTCF MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 0.00024 (Fisher's exact test), Q value = 0.047

Table S6.  Gene #4: 'CTCF MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
CTCF MUTATED 44 0 0
CTCF WILD-TYPE 156 4 44

Figure S6.  Get High-res Image Gene #4: 'CTCF MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'ARID1A MUTATION STATUS' versus 'Time to Death'

P value = 0.00218 (logrank test), Q value = 0.21

Table S7.  Gene #7: 'ARID1A MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 248 29 0.6 - 185.8 (34.6)
ARID1A MUTATED 83 2 1.0 - 129.8 (36.1)
ARID1A WILD-TYPE 165 27 0.6 - 185.8 (31.1)

Figure S7.  Get High-res Image Gene #7: 'ARID1A MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

'ARID1A MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 9e-05 (Fisher's exact test), Q value = 0.021

Table S8.  Gene #7: 'ARID1A MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
ARID1A MUTATED 78 1 4
ARID1A WILD-TYPE 122 3 40

Figure S8.  Get High-res Image Gene #7: 'ARID1A MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'KRAS MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 0.000317 (Wilcoxon-test), Q value = 0.051

Table S9.  Gene #9: 'KRAS MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
KRAS MUTATED 52 58.6 (8.7)
KRAS WILD-TYPE 196 64.3 (11.4)

Figure S9.  Get High-res Image Gene #9: 'KRAS MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'KRAS MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 0.00033 (Fisher's exact test), Q value = 0.051

Table S10.  Gene #9: 'KRAS MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
KRAS MUTATED 51 0 1
KRAS WILD-TYPE 149 4 43

Figure S10.  Get High-res Image Gene #9: 'KRAS MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'CTNNB1 MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 0.000515 (Wilcoxon-test), Q value = 0.071

Table S11.  Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
CTNNB1 MUTATED 74 59.6 (11.6)
CTNNB1 WILD-TYPE 174 64.6 (10.6)

Figure S11.  Get High-res Image Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'CTNNB1 MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S12.  Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
CTNNB1 MUTATED 74 0 0
CTNNB1 WILD-TYPE 126 4 44

Figure S12.  Get High-res Image Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'PPP2R1A MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 0.00088 (Fisher's exact test), Q value = 0.1

Table S13.  Gene #16: 'PPP2R1A MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
PPP2R1A MUTATED 15 1 12
PPP2R1A WILD-TYPE 185 3 32

Figure S13.  Get High-res Image Gene #16: 'PPP2R1A MUTATION STATUS' versus Clinical Feature #4: 'HISTOLOGICAL_TYPE'

'ARID5B MUTATION STATUS' versus 'RACE'

P value = 0.00233 (Fisher's exact test), Q value = 0.21

Table S14.  Gene #26: 'ARID5B MUTATION STATUS' versus Clinical Feature #6: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER WHITE
ALL 3 13 25 7 194
ARID5B MUTATED 1 5 0 2 20
ARID5B WILD-TYPE 2 8 25 5 174

Figure S14.  Get High-res Image Gene #26: 'ARID5B MUTATION STATUS' versus Clinical Feature #6: 'RACE'

'WDR65 MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 0.000997 (Wilcoxon-test), Q value = 0.11

Table S15.  Gene #135: 'WDR65 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
WDR65 MUTATED 6 48.5 (8.1)
WDR65 WILD-TYPE 242 63.5 (10.9)

Figure S15.  Get High-res Image Gene #135: 'WDR65 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

Methods & Data
Input

  • Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline

  • Processed Mutation data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/UCEC-TP/20217348/transformed.cor.cli.txt

  • Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/UCEC-TP/19775642/UCEC-TP.merged_data.txt

  • Number of patients = 248

  • Number of significantly mutated genes = 197

  • Number of selected clinical features = 7

  • Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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