Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q ZFPM1 24 (39%) 38 0.80381 1 0.81514 1 0.71768 1 0.87102 1 0.37295 1 0.74647 1 0.8242 1 0.92224 1 0.38344 1 0.74273 1 LACTB 19 (31%) 43 0.43775 1 0.6886 1 0.68599 1 0.56724 1 1 1 0.3179 1 0.37681 1 0.75138 1 0.32192 1 0.17937 1 CCDC102A 17 (27%) 45 0.01856 1 0.93383 1 0.67029 1 0.50639 1 0.97478 1 0.82333 1 0.49802 1 0.46861 1 0.80597 1 0.51089 1 ZNF517 13 (21%) 49 0.1667 1 0.98056 1 1 1 NA NA 0.82071 1 0.95127 1 0.17324 1 0.69637 1 0.72417 1 0.77494 1 MAL2 11 (18%) 51 0.49862 1 0.31185 1 1 1 1 1 0.25504 1 0.50605 1 0.22258 1 0.26807 1 1 1 0.86938 1 TOR3A 12 (19%) 50 0.61185 1 0.01352 1 0.15278 1 0.31329 1 0.67401 1 0.0053999 1 1 1 0.84258 1 0.91131 1 0.80754 1 TP53 13 (21%) 49 0.11434 1 0.81756 1 0.22126 1 0.60282 1 0.02077 1 0.32087 1 0.0052299 1 0.59779 1 0.04934 1 0.18472 1 CLDN23 10 (16%) 52 0.56671 1 0.25 1 1 1 0.34954 1 0.02952 1 0.21102 1 0.097499 1 0.18209 1 0.41683 1 0.5435 1 GDF1 5 (8%) 57 0.85854 1 0.28633 1 1 1 NA NA 0.43645 1 0.35354 1 0.055329 1 0.51141 1 0.1722 1 0.17346 1 LZTR1 6 (10%) 56 0.052529 1 0.85229 1 1 1 NA NA 0.088329 1 0.11713 1 0.40118 1 0.01539 1 1 1 0.45476 1 ANKRD43 19 (31%) 43 0.1613 1 0.56448 1 0.68599 1 0.60275 1 0.28003 1 0.22782 1 0.36663 1 0.10183 1 0.60564 1 0.4629 1 KCNK17 9 (15%) 53 0.20364 1 0.04031 1 0.01784 1 0.44172 1 0.10388 1 0.0089199 1 0.88936 1 0.54606 1 0.71842 1 0.44458 1 RINL 8 (13%) 54 0.34136 1 0.67635 1 1 1 0.57941 1 0.4689 1 0.27711 1 0.76128 1 0.17031 1 0.34776 1 0.74937 1 ZAR1 11 (18%) 51 0.64474 1 0.6698 1 1 1 0.79216 1 0.62182 1 0.86924 1 0.71414 1 0.97092 1 1 1 0.60203 1 CTNNB1 8 (13%) 54 0.39632 1 0.060869 1 0.63889 1 0.31372 1 0.0054499 1 0.0062499 1 7.9999e-05 0.0928 0.16993 1 0.04576 1 0.54748 1 APOE 7 (11%) 55 1 1 0.59467 1 1 1 0.38191 1 0.059159 1 0.39881 1 0.19304 1 0.7906 1 0.42018 1 1 1 GPRIN2 8 (13%) 54 0.86707 1 0.38308 1 1 1 0.69381 1 0.68142 1 0.4003 1 0.58117 1 0.75457 1 0.59395 1 0.18039 1 ASPDH 8 (13%) 54 0.29532 1 0.69096 1 1 1 0.31488 1 0.02341 1 0.39558 1 0.47551 1 0.03231 1 0.21137 1 0.081229 1 ERCC2 10 (16%) 52 1 1 0.23279 1 0.037681 1 0.23146 1 0.48225 1 0.17421 1 0.59935 1 0.27032 1 0.33576 1 0.20663 1 IDUA 8 (13%) 54 0.38427 1 0.85243 1 1 1 0.79248 1 0.50857 1 0.54893 1 0.1995 1 0.4296 1 0.45845 1 0.64699 1 C1ORF106 9 (15%) 53 0.84103 1 0.46956 1 0.63889 1 0.04693 1 0.34041 1 0.75939 1 0.47394 1 0.6892 1 0.052989 1 1 1 C10ORF95 6 (10%) 56 0.19863 1 0.37888 1 1 1 NA NA 0.51367 1 1 1 0.48818 1 0.35917 1 1 1 1 1 RGS9BP 8 (13%) 54 0.72406 1 0.62879 1 1 1 0.12871 1 1 1 0.93361 1 0.21837 1 0.96245 1 0.34213 1 0.74982 1 THEM4 5 (8%) 57 0.27894 1 0.76647 1 1 1 NA NA 0.43785 1 0.87673 1 0.17895 1 0.10879 1 0.231 1 0.26177 1 TSC22D2 8 (13%) 54 0.94596 1 0.54065 1 1 1 0.95412 1 0.77929 1 0.81671 1 0.76016 1 0.43179 1 0.34676 1 1 1 SYT8 8 (13%) 54 0.44094 1 0.43995 1 1 1 1 1 0.04174 1 0.17565 1 1 1 0.18438 1 0.74893 1 0.49708 1 PLIN5 5 (8%) 57 0.50237 1 0.69546 1 1 1 0.38292 1 0.80037 1 0.66807 1 0.26634 1 0.26827 1 0.51096 1 0.04764 1 LRIG1 16 (26%) 46 0.54228 1 0.95907 1 1 1 1 1 0.86425 1 0.61003 1 0.36396 1 0.43044 1 0.57654 1 0.90342 1 HHIPL1 6 (10%) 56 0.27665 1 0.43589 1 0.48413 1 NA NA 0.63213 1 0.51265 1 0.20435 1 0.42478 1 0.20184 1 0.33358 1 CCDC105 6 (10%) 56 1 1 0.0114 1 0.22619 1 0.67644 1 0.93926 1 0.79407 1 1 1 0.053839 1 0.21573 1 0.20751 1 C19ORF10 7 (11%) 55 0.7825 1 0.42332 1 0.6 1 0.39441 1 0.24037 1 0.12371 1 0.55149 1 0.8628 1 0.63939 1 0.71448 1 OPRD1 12 (19%) 50 0.96668 1 0.43542 1 0.65459 1 0.47957 1 0.7982 1 0.95988 1 0.2977 1 0.61132 1 1 1 0.51295 1 ATXN1 10 (16%) 52 0.556 1 0.13911 1 0.6 1 0.91568 1 0.24049 1 0.65391 1 0.28609 1 0.8711 1 0.23611 1 0.31614 1 AATK 6 (10%) 56 0.13889 1 0.33308 1 1 1 NA NA 0.43781 1 0.35569 1 1 1 0.54472 1 1 1 0.6201 1 ZNF628 7 (11%) 55 0.2087 1 0.92578 1 1 1 0.6724 1 0.30699 1 0.11382 1 0.091289 1 0.50187 1 0.28325 1 0.54447 1 KRTAP4-5 5 (8%) 57 0.63211 1 0.28539 1 0.48413 1 NA NA 0.90897 1 0.87516 1 1 1 0.84003 1 0.4344 1 1 1 NOXA1 5 (8%) 57 0.14233 1 0.51514 1 1 1 NA NA 0.22267 1 0.44454 1 0.29404 1 0.34935 1 0.25516 1 0.71915 1 TRIOBP 10 (16%) 52 0.62219 1 0.22872 1 0.58333 1 0.12846 1 1 1 0.11118 1 0.71335 1 0.87182 1 1 1 0.77405 1 ZNF598 12 (19%) 50 0.10837 1 0.31492 1 1 1 0.74756 1 0.49001 1 0.95179 1 1 1 0.22444 1 0.9015 1 1 1 IRX3 5 (8%) 57 0.14405 1 0.70396 1 0.48413 1 NA NA 0.52393 1 0.12038 1 0.17567 1 0.77822 1 0.23041 1 0.45171 1 WDR34 5 (8%) 57 0.62928 1 0.8293 1 0.48413 1 NA NA 0.86511 1 0.81314 1 0.84333 1 0.5467 1 0.84391 1 0.3321 1 BHLHE22 5 (8%) 57 0.42625 1 0.073499 1 1 1 0.91571 1 0.1183 1 0.81408 1 0.58317 1 0.83652 1 0.72615 1 0.83474 1 PANK2 5 (8%) 57 0.63079 1 0.4344 1 0.22619 1 0.35258 1 0.11407 1 0.050429 1 0.42714 1 0.34894 1 1 1 0.25493 1 FPGS 5 (8%) 57 1 1 1 1 1 1 0.35075 1 0.66681 1 0.60103 1 0.055589 1 0.62297 1 0.82316 1 0.61688 1 GLTPD2 6 (10%) 56 0.87918 1 0.84144 1 0.48413 1 NA NA 0.82887 1 0.39678 1 0.54932 1 0.52855 1 0.87274 1 0.1319 1 TNIP2 5 (8%) 57 0.63076 1 0.70538 1 1 1 NA NA 0.73847 1 0.87682 1 1 1 0.41376 1 1 1 0.45313 1 AKAP2 6 (10%) 56 0.11424 1 0.84115 1 1 1 0.75284 1 0.83001 1 0.59351 1 0.74717 1 0.28186 1 0.74926 1 0.40984 1 RREB1 5 (8%) 57 0.72844 1 0.85007 1 0.20635 1 NA NA 0.61917 1 1 1 0.52615 1 0.54794 1 0.17174 1 0.35242 1 TPO 12 (19%) 50 0.26195 1 0.29967 1 0.10159 1 0.69331 1 0.17561 1 0.12485 1 0.098029 1 0.34267 1 1 1 0.1699 1 OBSCN 18 (29%) 44 0.3107 1 0.51891 1 1 1 0.54429 1 0.67219 1 0.80651 1 0.15011 1 0.49779 1 1 1 0.38491 1 SNED1 5 (8%) 57 0.62807 1 0.31106 1 0.46429 1 NA NA 0.39733 1 0.66667 1 0.093569 1 0.66327 1 1 1 0.5426 1 MEN1 5 (8%) 57 0.41682 1 0.0491 1 0.48413 1 NA NA 0.01293 1 0.0062099 1 0.20579 1 0.04276 1 0.13961 1 0.204 1 BTBD11 6 (10%) 56 1 1 0.31264 1 1 1 NA NA 0.48523 1 1 1 0.48642 1 0.18469 1 0.72639 1 0.33269 1 RNF149 4 (6%) 58 0.33854 1 0.03677 1 0.58333 1 0.95476 1 0.43939 1 0.59989 1 0.31663 1 0.26083 1 0.66441 1 0.17336 1 KIAA1984 4 (6%) 58 0.41853 1 0.70911 1 0.22619 1 0.50594 1 0.12669 1 0.04939 1 0.0318 1 0.5845 1 0.6654 1 0.79606 1 CCDC150 4 (6%) 58 0.17722 1 0.84981 1 0.22619 1 0.60116 1 0.24069 1 0.11868 1 0.40015 1 0.21432 1 1 1 0.45262 1 FAM18B2 4 (6%) 58 0.74905 1 0.33349 1 1 1 NA NA 0.16605 1 0.48344 1 0.31416 1 0.50952 1 0.82376 1 0.1724 1 MUC5B 22 (35%) 40 1 1 0.62737 1 1 1 0.81151 1 0.73424 1 0.67253 1 0.7151 1 0.61547 1 1 1 0.52949 1 PTPLA 4 (6%) 58 0.42075 1 0.32343 1 1 1 NA NA 0.33775 1 0.44264 1 0.77657 1 1 1 0.77434 1 1 1 SRPX 3 (5%) 59 0.75417 1 0.11345 1 1 1 NA NA 0.61689 1 1 1 0.77737 1 0.71738 1 1 1 0.40205 1 GARS 19 (31%) 43 0.072989 1 0.090999 1 0.22754 1 0.33424 1 0.33822 1 0.1024 1 0.12069 1 0.40252 1 0.2133 1 0.39428 1 PRSS27 3 (5%) 59 1 1 0.91023 1 1 1 NA NA 0.62037 1 0.052289 1 0.12864 1 1 1 0.6143 1 0.55741 1 SEMA5B 8 (13%) 54 0.33687 1 0.26934 1 0.31111 1 0.17272 1 0.39789 1 0.21217 1 0.64868 1 0.30267 1 0.36169 1 0.41229 1 CD320 4 (6%) 58 1 1 0.85088 1 1 1 NA NA 0.73838 1 0.6577 1 0.3994 1 0.22792 1 0.22988 1 0.25977 1 TAF5 4 (6%) 58 1 1 0.7695 1 0.58333 1 0.95487 1 1 1 0.87615 1 0.0094899 1 0.11735 1 0.055719 1 0.01458 1 NEFH 6 (10%) 56 0.051649 1 0.17232 1 0.48413 1 NA NA 0.11344 1 0.051859 1 0.39926 1 0.21207 1 0.6676 1 0.45267 1 DMKN 3 (5%) 59 1 1 0.32838 1 0.46429 1 NA NA 0.61838 1 0.44356 1 0.0060099 1 0.56652 1 0.25446 1 1 1 NPTX1 3 (5%) 59 0.64091 1 1 1 0.46429 1 NA NA 1 1 0.81336 1 0.58281 1 0.79367 1 0.35057 1 0.55478 1 NOTCH2 5 (8%) 57 0.2792 1 0.89565 1 1 1 NA NA 0.52226 1 0.11475 1 0.03068 1 0.319 1 0.66652 1 0.79521 1 RNF39 5 (8%) 57 0.72587 1 0.37844 1 0.6 1 0.79381 1 0.17535 1 0.26513 1 0.15873 1 0.69967 1 0.23889 1 0.68459 1 KBTBD13 9 (15%) 53 0.45772 1 0.11382 1 0.31111 1 0.79133 1 0.68465 1 0.11779 1 1 1 0.32843 1 1 1 0.60294 1 IER5 3 (5%) 59 0.19919 1 NA NA 0.46429 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA SCRT1 3 (5%) 59 1 1 0.42912 1 0.46429 1 NA NA 0.47546 1 0.61709 1 0.43239 1 0.79451 1 0.46656 1 1 1 KNDC1 9 (15%) 53 0.35313 1 0.065239 1 1 1 0.55222 1 0.02711 1 0.32449 1 0.42031 1 0.36634 1 0.19081 1 0.38152 1 MAP1S 5 (8%) 57 0.15515 1 0.27558 1 1 1 0.41774 1 0.39713 1 1 1 1 1 0.83413 1 0.42091 1 0.83574 1 RGMB 6 (10%) 56 0.65211 1 NA NA 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA LRP11 6 (10%) 56 1 1 0.081979 1 1 1 NA NA 0.79759 1 0.66485 1 0.58072 1 0.93575 1 0.83968 1 0.83689 1 AR 4 (6%) 58 0.41851 1 0.51642 1 1 1 0.95466 1 0.47642 1 0.44302 1 0.42909 1 1 1 0.2531 1 1 1 VARS 6 (10%) 56 1 1 0.42421 1 0.22619 1 0.38297 1 0.21818 1 0.066529 1 0.64628 1 0.86398 1 0.75069 1 1 1 SEZ6L2 8 (13%) 54 0.37954 1 0.66544 1 1 1 0.78824 1 0.82684 1 1 1 0.46035 1 0.63065 1 1 1 0.84872 1 PABPC1 4 (6%) 58 0.41962 1 NA NA 0.46429 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA FANK1 3 (5%) 59 1 1 0.32537 1 1 1 NA NA 0.8568 1 0.28538 1 0.77693 1 0.23473 1 0.77495 1 0.25778 1 NMU 5 (8%) 57 0.9136 1 1 1 0.46429 1 NA NA 0.070259 1 0.61397 1 1 1 0.54458 1 0.82564 1 0.621 1 ADAD2 4 (6%) 58 0.41807 1 0.57351 1 1 1 NA NA 0.74016 1 0.17133 1 0.0093099 1 0.51142 1 0.057209 1 0.35293 1 CLIC6 5 (8%) 57 0.63174 1 1 1 0.20635 1 NA NA 0.66575 1 0.11783 1 0.17719 1 0.58393 1 0.29269 1 1 1 PCDHB13 5 (8%) 57 0.3941 1 0.14073 1 0.48413 1 NA NA 0.12747 1 0.35538 1 0.66573 1 0.060759 1 0.43826 1 0.45349 1 PLEC 13 (21%) 49 0.4262 1 0.67297 1 0.33333 1 0.04608 1 0.20654 1 0.71697 1 0.5979 1 0.63372 1 0.14188 1 0.62518 1 AMDHD1 10 (16%) 52 0.65785 1 0.75964 1 0.22619 1 0.35159 1 0.5895 1 0.13697 1 0.17572 1 0.85145 1 0.90169 1 0.68306 1 DSPP 9 (15%) 53 0.60928 1 0.060649 1 1 1 0.69238 1 1 1 0.48207 1 0.44401 1 0.53841 1 0.89969 1 1 1 TMEM189 3 (5%) 59 0.19462 1 NA NA 0.46429 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA CRIPAK 10 (16%) 52 0.38538 1 0.92732 1 0.6 1 0.93373 1 0.48677 1 0.68882 1 0.89369 1 0.32894 1 0.47689 1 0.36506 1 PDCD6 3 (5%) 59 0.2993 1 0.649 1 0.46429 1 NA NA NA NA NA NA 1 1 0.63979 1 1 1 1 1 MAP7 3 (5%) 59 1 1 0.64993 1 0.46429 1 NA NA 1 1 0.81394 1 0.5819 1 0.79245 1 1 1 0.55745 1 NOM1 6 (10%) 56 1 1 0.31275 1 1 1 NA NA 0.86386 1 1 1 1 1 0.78839 1 0.42009 1 1 1 SHOX2 3 (5%) 59 0.408 1 NA NA 0.46429 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA HSD17B1 4 (6%) 58 0.91433 1 0.04992 1 0.58333 1 0.50629 1 0.90857 1 0.0080099 1 1 1 0.84232 1 0.54743 1 0.79564 1 PRKAR1A 6 (10%) 56 0.61523 1 1 1 0.6 1 0.79289 1 0.27711 1 0.40195 1 0.10311 1 0.5908 1 0.04766 1 0.58681 1 KRTAP5-5 3 (5%) 59 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA DLEU7 3 (5%) 59 0.52836 1 NA NA 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA FEZ2 3 (5%) 59 0.46303 1 0.35466 1 1 1 NA NA 0.21927 1 0.81486 1 0.1926 1 0.79358 1 0.77441 1 0.55739 1 RASIP1 6 (10%) 56 0.36004 1 0.34874 1 1 1 NA NA 0.04116 1 0.18757 1 0.055059 1 0.70013 1 0.41821 1 0.71314 1 JMJD4 3 (5%) 59 1 1 NA NA 0.48413 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA COQ2 5 (8%) 57 0.35998 1 0.76619 1 1 1 NA NA 0.43801 1 0.60127 1 1 1 0.67143 1 0.54897 1 0.61914 1 UQCRFS1 5 (8%) 57 0.75311 1 0.58723 1 0.48413 1 NA NA 1 1 0.87677 1 0.4876 1 0.20265 1 0.84162 1 0.33317 1 C9ORF66 5 (8%) 57 1 1 0.92754 1 1 1 NA NA 1 1 0.51246 1 0.57585 1 0.93572 1 0.3482 1 0.54158 1 POLRMT 4 (6%) 58 0.30461 1 0.02993 1 0.087302 1 0.3479 1 0.36329 1 0.059619 1 0.24187 1 0.25832 1 0.35608 1 0.17479 1 ADAMTS7 4 (6%) 58 0.20014 1 0.47859 1 0.087302 1 0.34825 1 0.089399 1 0.43514 1 0.082039 1 0.25666 1 0.12161 1 0.03757 1 BTNL9 4 (6%) 58 1 1 0.112 1 1 1 NA NA 0.14382 1 0.097499 1 0.13034 1 1 1 0.25453 1 1 1 NF1 7 (11%) 55 0.25145 1 0.90288 1 0.10159 1 0.39389 1 0.36149 1 0.19212 1 0.28098 1 0.88613 1 1 1 0.099559 1 ZNF814 3 (5%) 59 1 1 NA NA 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA RNF135 3 (5%) 59 0.75233 1 NA NA 0.46429 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA CSGALNACT2 3 (5%) 59 0.16114 1 0.03634 1 0.46429 1 NA NA 0.77264 1 0.81319 1 0.5814 1 0.8751 1 0.34999 1 0.40398 1 SPIRE2 3 (5%) 59 0.30008 1 0.03822 1 1 1 NA NA 1 1 0.81536 1 1 1 0.7919 1 1 1 1 1 CYP4A22 4 (6%) 58 0.17723 1 0.70581 1 1 1 NA NA 0.16755 1 0.48317 1 0.17926 1 0.1967 1 0.082549 1 0.61727 1 HLA-A 3 (5%) 59 1 1 1 1 1 1 NA NA 0.85561 1 0.19279 1 1 1 0.50562 1 0.77737 1 0.25435 1 GLI3 5 (8%) 57 0.8587 1 0.43257 1 NA NA NA NA 0.91082 1 0.87686 1 0.12456 1 0.41457 1 0.29022 1 0.25799 1