Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.043 0.25 0.495 2.0 -0.555 12.0 14.0 IHH 0.004 0.14 0.245 6.0 -0.4 5.0 11.0 SHH Np/Cholesterol/GAS1 -0.049 0.125 -9999.0 0.0 -0.263 18.0 18.0 LRPAP1 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.049 0.125 0.261 18.0 -9999.0 0.0 18.0 SMO/beta Arrestin2 -0.077 0.181 -9999.0 0.0 -0.416 7.0 7.0 SMO -0.085 0.18 -9999.0 0.0 -0.433 7.0 7.0 AKT1 -0.041 0.132 -9999.0 0.0 -0.634 2.0 2.0 ARRB2 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.017 0.08 0.241 2.0 -0.422 2.0 4.0 ADRBK1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.084 0.178 -9999.0 0.0 -0.427 7.0 7.0 STIL -0.068 0.146 0.274 3.0 -0.284 12.0 15.0 DHH N/PTCH2 0.041 0.078 0.185 10.0 -0.305 2.0 12.0 DHH N/PTCH1 -0.011 0.14 0.318 1.0 -0.287 11.0 12.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.035 0.103 0.241 9.0 -0.422 2.0 11.0 PTHLH -0.099 0.352 0.697 1.0 -0.854 12.0 13.0 determination of left/right symmetry -0.084 0.178 -9999.0 0.0 -0.427 7.0 7.0 PIK3R1 0.006 0.09 0.241 1.0 -0.422 3.0 4.0 skeletal system development -0.097 0.348 0.695 1.0 -0.843 12.0 13.0 IHH N/Hhip -0.025 0.166 0.211 6.0 -0.32 16.0 22.0 DHH N/Hhip -0.002 0.146 0.2 11.0 -0.281 14.0 25.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.084 0.178 -9999.0 0.0 -0.427 7.0 7.0 pancreas development -0.031 0.18 0.241 7.0 -0.421 12.0 19.0 HHAT 0.012 0.071 -9999.0 0.0 -0.422 2.0 2.0 PI3K 0.018 0.069 0.185 1.0 -0.305 3.0 4.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.003 0.113 0.241 1.0 -0.422 5.0 6.0 somite specification -0.084 0.178 -9999.0 0.0 -0.427 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.061 0.149 0.311 2.0 -0.276 14.0 16.0 SHH Np/Cholesterol/PTCH2 -0.03 0.116 0.228 2.0 -0.245 15.0 17.0 SHH Np/Cholesterol/Megalin -0.046 0.103 -9999.0 0.0 -0.241 15.0 15.0 SHH -0.066 0.133 0.163 4.0 -0.315 15.0 19.0 catabolic process -0.024 0.151 0.258 2.0 -0.322 13.0 15.0 SMO/Vitamin D3 -0.086 0.167 0.333 2.0 -0.337 11.0 13.0 SHH Np/Cholesterol/Hhip -0.061 0.157 0.188 5.0 -0.274 23.0 28.0 LRP2 0.007 0.034 0.241 1.0 -9999.0 0.0 1.0 receptor-mediated endocytosis -0.088 0.161 0.292 2.0 -0.385 6.0 8.0 SHH Np/Cholesterol/BOC -0.037 0.114 0.151 1.0 -0.24 17.0 18.0 SHH Np/Cholesterol/CDO -0.042 0.112 0.154 1.0 -0.236 18.0 19.0 mesenchymal cell differentiation 0.061 0.155 0.272 23.0 -0.186 5.0 28.0 mol:Vitamin D3 -0.056 0.16 0.326 3.0 -0.287 12.0 15.0 IHH N/PTCH2 0.025 0.093 0.199 4.0 -0.272 4.0 8.0 CDON 0.013 0.098 0.241 3.0 -0.422 3.0 6.0 IHH N/PTCH1 -0.008 0.166 0.328 3.0 -0.324 13.0 16.0 Megalin/LRPAP1 0.032 0.021 0.185 1.0 -9999.0 0.0 1.0 PTCH2 0.028 0.035 0.241 2.0 -9999.0 0.0 2.0 SHH Np/Cholesterol -0.054 0.096 -9999.0 0.0 -0.24 15.0 15.0 PTCH1 -0.024 0.151 0.258 2.0 -0.323 13.0 15.0 HHIP -0.031 0.18 0.241 7.0 -0.422 12.0 19.0