E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.019 0.11 -9999.0 0.0 -0.443 29.0 29.0 KLHL20 0.016 0.064 0.236 9.0 -0.223 12.0 21.0 CYFIP2 0.028 0.048 0.255 26.0 -0.566 3.0 29.0 Rac1/GDP 0.001 0.084 0.26 8.0 -0.311 15.0 23.0 ENAH -0.014 0.103 -9999.0 0.0 -0.449 24.0 24.0 AP1M1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.01 0.046 -9999.0 0.0 -0.404 1.0 1.0 ABI1/Sra1/Nap1 -0.012 0.031 -9999.0 0.0 -0.164 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.047 0.064 -9999.0 0.0 -0.331 20.0 20.0 RAPGEF1 -0.018 0.105 0.258 2.0 -0.402 25.0 27.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.021 0.122 -9999.0 0.0 -0.41 50.0 50.0 CRK -0.015 0.099 -9999.0 0.0 -0.42 29.0 29.0 E-cadherin/gamma catenin/alpha catenin 0.033 0.057 -9999.0 0.0 -0.361 18.0 18.0 alphaE/beta7 Integrin 0.036 0.034 -9999.0 0.0 -0.419 2.0 2.0 IQGAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.027 -9999.0 0.0 -0.329 3.0 3.0 DLG1 -0.023 0.116 -9999.0 0.0 -0.443 32.0 32.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.031 -9999.0 0.0 -0.285 1.0 1.0 MLLT4 0.021 0.032 0.255 1.0 -0.566 3.0 4.0 ARF6/GTP/NME1/Tiam1 0.044 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.003 0.045 -9999.0 0.0 -0.381 1.0 1.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.021 0.062 -9999.0 0.0 -0.419 18.0 18.0 TIAM1 0.025 0.015 0.255 4.0 -9999.0 0.0 4.0 E-cadherin(dimer)/Ca2+ 0.041 0.054 -9999.0 0.0 -0.312 18.0 18.0 AKT1 -0.007 0.035 0.137 1.0 -0.209 1.0 2.0 PIK3R1 0.016 0.065 -9999.0 0.0 -0.566 13.0 13.0 CDH1 0.012 0.076 -9999.0 0.0 -0.566 18.0 18.0 RhoA/GDP 0.002 0.083 0.259 8.0 -0.311 15.0 23.0 actin cytoskeleton organization 0.015 0.052 0.181 19.0 -0.164 11.0 30.0 CDC42/GDP 0.002 0.082 0.259 8.0 -0.311 15.0 23.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.008 0.04 -9999.0 0.0 -0.265 18.0 18.0 ITGB7 0.03 0.046 0.255 30.0 -0.566 2.0 32.0 RAC1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.045 0.057 -9999.0 0.0 -0.331 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.03 0.049 -9999.0 0.0 -0.31 18.0 18.0 mol:GDP -0.012 0.09 0.267 8.0 -0.358 16.0 24.0 CDC42/GTP/IQGAP1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.006 0.085 0.264 5.0 -0.37 3.0 8.0 RAC1/GTP/IQGAP1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.047 0.175 39.0 -0.238 4.0 43.0 NME1 0.026 0.031 0.255 18.0 -9999.0 0.0 18.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.021 0.114 -9999.0 0.0 -0.447 31.0 31.0 regulation of cell-cell adhesion 0.004 0.039 -9999.0 0.0 -0.348 1.0 1.0 WASF2 0.008 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.014 0.056 0.244 1.0 -0.462 1.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.054 0.064 -9999.0 0.0 -0.315 19.0 19.0 CCND1 0.015 0.054 0.198 38.0 -0.3 4.0 42.0 VAV2 -0.018 0.147 -9999.0 0.0 -0.617 23.0 23.0 RAP1/GDP 0.008 0.069 0.264 3.0 -0.453 1.0 4.0 adherens junction assembly -0.02 0.111 -9999.0 0.0 -0.432 31.0 31.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.042 0.061 -9999.0 0.0 -0.305 19.0 19.0 E-cadherin/beta catenin 0.001 0.057 -9999.0 0.0 -0.34 28.0 28.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.022 0.115 -9999.0 0.0 -0.435 32.0 32.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.004 0.089 0.256 33.0 -0.345 22.0 55.0 E-cadherin/beta catenin/alpha catenin 0.034 0.057 -9999.0 0.0 -0.36 18.0 18.0 ITGAE 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.124 -9999.0 0.0 -0.433 43.0 43.0