E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.036 0.148 -9999.0 0.0 -0.42 46.0 46.0 KLHL20 0.042 0.114 0.304 41.0 -0.258 14.0 55.0 CYFIP2 0.05 0.047 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.003 0.117 0.313 7.0 -0.301 25.0 32.0 ENAH -0.03 0.143 -9999.0 0.0 -0.405 46.0 46.0 AP1M1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.052 -9999.0 0.0 -0.543 4.0 4.0 CDC42/GTP 0.009 0.075 -9999.0 0.0 -0.29 2.0 2.0 ABI1/Sra1/Nap1 -0.015 0.04 -9999.0 0.0 -0.174 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.095 -9999.0 0.0 -0.31 26.0 26.0 RAPGEF1 -0.029 0.142 0.311 2.0 -0.397 40.0 42.0 CTNND1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.164 -9999.0 0.0 -0.438 51.0 51.0 CRK -0.026 0.145 0.346 1.0 -0.415 45.0 46.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.089 -9999.0 0.0 -0.343 21.0 21.0 alphaE/beta7 Integrin 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.054 0.042 -9999.0 0.0 -0.309 3.0 3.0 DLG1 -0.038 0.158 -9999.0 0.0 -0.422 53.0 53.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.061 -9999.0 0.0 -0.207 9.0 9.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.542 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.058 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.08 -9999.0 0.0 -0.272 8.0 8.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.021 0.095 -9999.0 0.0 -0.326 31.0 31.0 TIAM1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.047 0.089 -9999.0 0.0 -0.292 26.0 26.0 AKT1 -0.007 0.056 -9999.0 0.0 -0.197 1.0 1.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.543 47.0 47.0 CDH1 0.007 0.118 -9999.0 0.0 -0.542 22.0 22.0 RhoA/GDP 0.002 0.116 0.306 7.0 -0.302 25.0 32.0 actin cytoskeleton organization 0.037 0.093 0.255 43.0 -0.187 13.0 56.0 CDC42/GDP 0.001 0.116 0.326 4.0 -0.347 6.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.005 0.066 -9999.0 0.0 -0.251 23.0 23.0 ITGB7 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.051 0.095 -9999.0 0.0 -0.311 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.082 -9999.0 0.0 -0.29 26.0 26.0 mol:GDP -0.017 0.123 0.315 6.0 -0.341 30.0 36.0 CDC42/GTP/IQGAP1 0.043 0.014 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.008 0.12 0.341 3.0 -0.309 24.0 27.0 RAC1/GTP/IQGAP1 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.067 0.216 20.0 -0.225 11.0 31.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.036 0.157 -9999.0 0.0 -0.434 49.0 49.0 regulation of cell-cell adhesion -0.001 0.061 -9999.0 0.0 -0.255 2.0 2.0 WASF2 0.02 0.043 0.117 34.0 -0.11 4.0 38.0 Rap1/GTP 0.013 0.087 0.281 1.0 -0.327 2.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.092 -9999.0 0.0 -0.299 21.0 21.0 CCND1 0.017 0.079 0.244 20.0 -0.283 11.0 31.0 VAV2 -0.018 0.192 0.413 1.0 -0.648 17.0 18.0 RAP1/GDP 0.012 0.101 0.311 3.0 -0.349 4.0 7.0 adherens junction assembly -0.034 0.154 -9999.0 0.0 -0.42 49.0 49.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.045 0.088 -9999.0 0.0 -0.288 24.0 24.0 E-cadherin/beta catenin -0.006 0.089 -9999.0 0.0 -0.335 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.036 0.157 -9999.0 0.0 -0.421 53.0 53.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.013 0.144 0.279 59.0 -0.423 17.0 76.0 E-cadherin/beta catenin/alpha catenin 0.036 0.095 -9999.0 0.0 -0.339 26.0 26.0 ITGAE 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.031 0.167 -9999.0 0.0 -0.448 51.0 51.0