Correlation between copy number variations of arm-level result and selected clinical features
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (Primary solid tumor)
21 August 2015  |  analyses__2015_08_21
Maintainer Information
Citation Information
doi:10.7908/C1GM86FZ
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2015): Correlation between copy number variations of arm-level result and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C1GM86FZ
Overview
Introduction

This pipeline computes the correlation between significant arm-level copy number variations (cnvs) and selected clinical features.

Summary

Testing the association between copy number variation 82 arm-level events and 39 clinical features across 295 patients, 22 significant findings detected with Q value < 0.25.

  • 8q gain cnv correlated to 'PATHOLOGY_T_STAGE'.

  • 9q gain cnv correlated to 'PREGNANCIES_COUNT_LIVE_BIRTH'.

  • xp gain cnv correlated to 'PREGNANCIES_COUNT_LIVE_BIRTH'.

  • 3p loss cnv correlated to 'NUMBER_OF_LYMPH_NODES',  'LYMPHOVASCULAR_INVOLVEMENT', and 'LYMPH_NODES_EXAMINED_HE_COUNT'.

  • 4p loss cnv correlated to 'HISTOLOGICAL_TYPE',  'NUMBER_OF_LYMPH_NODES', and 'LYMPH_NODES_EXAMINED_HE_COUNT'.

  • 4q loss cnv correlated to 'RADIATION_THERAPY' and 'NEOPLASM_HISTOLOGIC_GRADE'.

  • 8p loss cnv correlated to 'TOBACCO_SMOKING_YEAR_STOPPED'.

  • 10q loss cnv correlated to 'NEOPLASM_HISTOLOGIC_GRADE'.

  • 11p loss cnv correlated to 'YEARS_TO_BIRTH' and 'AGE_AT_DIAGNOSIS'.

  • 11q loss cnv correlated to 'YEARS_TO_BIRTH',  'MENOPAUSE_STATUS', and 'AGE_AT_DIAGNOSIS'.

  • 16q loss cnv correlated to 'HISTOLOGICAL_TYPE'.

  • 18q loss cnv correlated to 'HISTOLOGICAL_TYPE'.

  • 19p loss cnv correlated to 'Time to Death'.

  • 20q loss cnv correlated to 'Time to Death'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between significant copy number variation of 82 arm-level events and 39 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 22 significant findings detected.

Clinical
Features 		Time
to
Death 		YEARS
TO
BIRTH 		PATHOLOGY
T
STAGE 		PATHOLOGY
N
STAGE 		PATHOLOGY
M
STAGE 		RADIATION
THERAPY 		HISTOLOGICAL
TYPE 		NUMBER
PACK
YEARS
SMOKED 		NUMBER
OF
LYMPH
NODES 		RACE ETHNICITY WEIGHT
KG
AT
DIAGNOSIS 		TUMOR
STATUS 		NEOPLASM
HISTOLOGIC
GRADE 		TOBACCO
SMOKING
YEAR
STOPPED 		TOBACCO
SMOKING
PACK
YEARS
SMOKED 		TOBACCO
SMOKING
HISTORY 		AGEBEGANSMOKINGINYEARS RADIATION
THERAPY
STATUS 		PREGNANCIES
COUNT
TOTAL 		PREGNANCIES
COUNT
STILLBIRTH 		PREGNANCY
SPONTANEOUS
ABORTION
COUNT 		PREGNANCIES
COUNT
LIVE
BIRTH 		PREGNANCY
THERAPEUTIC
ABORTION
COUNT 		PREGNANCIES
COUNT
ECTOPIC 		POS
LYMPH
NODE
LOCATION 		MENOPAUSE
STATUS 		LYMPHOVASCULAR
INVOLVEMENT 		LYMPH
NODES
EXAMINED
HE
COUNT 		LYMPH
NODES
EXAMINED 		KERATINIZATION
SQUAMOUS
CELL 		INITIAL
PATHOLOGIC
DX
YEAR 		HISTORY
HORMONAL
CONTRACEPTIVES
USE 		HEIGHT
CM
AT
DIAGNOSIS 		CORPUS
INVOLVEMENT 		CHEMO
CONCURRENT
TYPE 		CERVIX
SUV
RESULTS 		AGE
AT
DIAGNOSIS 		CLINICAL
STAGE
nCNV (%) nWild-Type logrank test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test Fisher's exact test Wilcoxon-test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test Wilcoxon-test Fisher's exact test Wilcoxon-test Wilcoxon-test Wilcoxon-test Wilcoxon-test Wilcoxon-test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test Wilcoxon-test Fisher's exact test Wilcoxon-test Fisher's exact test Fisher's exact test Wilcoxon-test Wilcoxon-test Fisher's exact test
3p loss 82 (28%) 213 0.623
(1.00) 		0.514
(0.997) 		0.349
(0.97) 		0.0101
(0.525) 		0.283
(0.928) 		0.451
(0.994) 		0.00763
(0.511) 		0.453
(0.994) 		0.000785
(0.185) 		0.61
(1.00) 		0.809
(1.00) 		0.748
(1.00) 		0.643
(1.00) 		0.624
(1.00) 		0.158
(0.806) 		0.453
(0.994) 		0.003
(0.384) 		0.234
(0.895) 		1
(1.00) 		0.872
(1.00) 		0.521
(0.997) 		0.858
(1.00) 		0.46
(0.994) 		0.723
(1.00) 		0.0285
(0.607) 		0.112
(0.771) 		0.845
(1.00) 		0.00159
(0.231) 		0.000785
(0.185) 		0.55
(0.997) 		0.584
(1.00) 		0.0301
(0.607) 		0.138
(0.798) 		0.051
(0.638) 		0.391
(0.97) 		0.796
(1.00) 		0.0149
(0.575) 		0.467
(0.994) 		0.627
(1.00)
4p loss 131 (44%) 164 0.462
(0.994) 		0.685
(1.00) 		0.138
(0.798) 		0.00585
(0.456) 		0.525
(0.997) 		0.0219
(0.607) 		0.00134
(0.214) 		0.36
(0.97) 		0.0011
(0.185) 		0.333
(0.959) 		0.261
(0.906) 		0.0646
(0.685) 		1
(1.00) 		0.144
(0.806) 		0.368
(0.97) 		0.36
(0.97) 		0.29
(0.93) 		0.805
(1.00) 		0.583
(1.00) 		0.217
(0.869) 		0.278
(0.927) 		0.957
(1.00) 		0.113
(0.771) 		0.186
(0.83) 		0.48
(0.997) 		0.451
(0.994) 		0.458
(0.994) 		0.237
(0.895) 		0.0011
(0.185) 		0.344
(0.967) 		0.307
(0.943) 		0.103
(0.758) 		0.661
(1.00) 		0.596
(1.00) 		0.795
(1.00) 		0.0565
(0.655) 		0.885
(1.00) 		0.685
(1.00) 		0.458
(0.994)
11q loss 115 (39%) 180 0.586
(1.00) 		8.58e-05
(0.137) 		0.553
(0.997) 		0.867
(1.00) 		1
(1.00) 		0.514
(0.997) 		0.167
(0.821) 		0.805
(1.00) 		0.474
(0.994) 		0.173
(0.821) 		0.356
(0.97) 		0.732
(1.00) 		0.0243
(0.607) 		0.755
(1.00) 		0.641
(1.00) 		0.805
(1.00) 		0.572
(1.00) 		0.0516
(0.64) 		1
(1.00) 		0.0275
(0.607) 		0.0531
(0.645) 		0.209
(0.857) 		0.0773
(0.719) 		0.0794
(0.719) 		0.0102
(0.525) 		0.399
(0.97) 		0.00107
(0.185) 		0.389
(0.97) 		0.474
(0.994) 		0.286
(0.929) 		0.861
(1.00) 		0.622
(1.00) 		0.602
(1.00) 		0.19
(0.832) 		0.283
(0.928) 		0.567
(1.00) 		0.225
(0.881) 		0.000136
(0.145) 		0.269
(0.915)
4q loss 93 (32%) 202 0.255
(0.905) 		0.523
(0.997) 		0.0915
(0.743) 		0.0327
(0.607) 		0.295
(0.931) 		0.000855
(0.185) 		0.226
(0.881) 		0.663
(1.00) 		0.0123
(0.528) 		0.472
(0.994) 		0.225
(0.881) 		0.0286
(0.607) 		0.377
(0.97) 		0.0006
(0.185) 		0.42
(0.993) 		0.663
(1.00) 		0.467
(0.994) 		0.405
(0.976) 		0.543
(0.997) 		0.565
(1.00) 		0.687
(1.00) 		0.473
(0.994) 		0.466
(0.994) 		0.181
(0.83) 		0.99
(1.00) 		0.329
(0.956) 		0.869
(1.00) 		0.359
(0.97) 		0.0123
(0.528) 		0.462
(0.994) 		0.589
(1.00) 		0.137
(0.798) 		0.812
(1.00) 		0.907
(1.00) 		0.762
(1.00) 		0.834
(1.00) 		0.157
(0.806) 		0.543
(0.997) 		0.698
(1.00)
11p loss 100 (34%) 195 0.551
(0.997) 		0.000512
(0.185) 		0.348
(0.97) 		0.86
(1.00) 		0.497
(0.997) 		0.866
(1.00) 		0.068
(0.705) 		0.26
(0.906) 		0.853
(1.00) 		0.186
(0.83) 		0.814
(1.00) 		0.863
(1.00) 		0.0306
(0.607) 		0.108
(0.769) 		0.387
(0.97) 		0.26
(0.906) 		0.711
(1.00) 		0.365
(0.97) 		0.551
(0.997) 		0.00611
(0.466) 		0.0382
(0.607) 		0.512
(0.997) 		0.018
(0.586) 		0.386
(0.97) 		0.0341
(0.607) 		0.505
(0.997) 		0.0109
(0.525) 		0.357
(0.97) 		0.853
(1.00) 		0.574
(1.00) 		0.719
(1.00) 		0.29
(0.93) 		0.126
(0.771) 		0.0209
(0.607) 		0.405
(0.976) 		0.196
(0.843) 		0.225
(0.881) 		0.000436
(0.185) 		0.037
(0.607)
8q gain 91 (31%) 204 0.93
(1.00) 		0.125
(0.771) 		0.00156
(0.231) 		0.301
(0.936) 		0.288
(0.93) 		0.0903
(0.743) 		0.0175
(0.586) 		0.879
(1.00) 		0.729
(1.00) 		0.716
(1.00) 		0.632
(1.00) 		0.276
(0.927) 		0.652
(1.00) 		0.963
(1.00) 		0.336
(0.961) 		0.879
(1.00) 		0.53
(0.997) 		0.985
(1.00) 		0.53
(0.997) 		0.852
(1.00) 		0.627
(1.00) 		0.249
(0.9) 		0.884
(1.00) 		0.181
(0.83) 		0.53
(0.997) 		0.359
(0.97) 		0.555
(0.998) 		0.442
(0.994) 		0.729
(1.00) 		0.327
(0.954) 		0.29
(0.93) 		0.15
(0.806) 		0.159
(0.806) 		0.755
(1.00) 		1
(1.00) 		0.548
(0.997) 		0.961
(1.00) 		0.119
(0.771) 		0.309
(0.943)
9q gain 47 (16%) 248 0.904
(1.00) 		0.145
(0.806) 		0.159
(0.806) 		0.0785
(0.719) 		1
(1.00) 		1
(1.00) 		0.434
(0.994) 		0.128
(0.783) 		0.116
(0.771) 		0.121
(0.771) 		0.487
(0.997) 		0.566
(1.00) 		0.705
(1.00) 		0.492
(0.997) 		0.145
(0.806) 		0.128
(0.783) 		0.0371
(0.607) 		0.949
(1.00) 		1
(1.00) 		0.207
(0.855) 		0.93
(1.00) 		0.0345
(0.607) 		0.000954
(0.185) 		0.662
(1.00) 		0.134
(0.795) 		0.849
(1.00) 		0.803
(1.00) 		1
(1.00) 		0.116
(0.771) 		0.802
(1.00) 		0.173
(0.821) 		0.599
(1.00) 		0.564
(1.00) 		0.533
(0.997) 		0.351
(0.97) 		0.271
(0.918) 		0.95
(1.00) 		0.192
(0.835) 		0.251
(0.902)
xp gain 42 (14%) 253 0.237
(0.895) 		0.366
(0.97) 		0.0637
(0.685) 		0.492
(0.997) 		0.0542
(0.645) 		0.528
(0.997) 		0.572
(1.00) 		0.125
(0.771) 		0.647
(1.00) 		0.509
(0.997) 		1
(1.00) 		0.0659
(0.691) 		0.189
(0.832) 		0.499
(0.997) 		0.125
(0.771) 		0.125
(0.771) 		0.411
(0.983) 		0.395
(0.97) 		0.298
(0.934) 		0.00756
(0.511) 		0.0397
(0.607) 		0.356
(0.97) 		0.000884
(0.185) 		0.292
(0.93) 		0.816
(1.00) 		0.423
(0.993) 		0.495
(0.997) 		0.608
(1.00) 		0.647
(1.00) 		0.7
(1.00) 		0.497
(0.997) 		0.933
(1.00) 		0.188
(0.832) 		0.0842
(0.73) 		0.121
(0.771) 		0.503
(0.997) 		0.392
(0.97) 		0.702
(1.00)
8p loss 82 (28%) 213 0.0159
(0.586) 		0.435
(0.994) 		0.937
(1.00) 		0.588
(1.00) 		0.0611
(0.671) 		0.463
(0.994) 		0.614
(1.00) 		0.517
(0.997) 		0.486
(0.997) 		0.245
(0.895) 		1
(1.00) 		0.82
(1.00) 		0.0923
(0.743) 		0.173
(0.821) 		0.000626
(0.185) 		0.517
(0.997) 		0.429
(0.994) 		0.24
(0.895) 		0.543
(0.997) 		0.923
(1.00) 		0.583
(1.00) 		0.531
(0.997) 		0.558
(1.00) 		0.644
(1.00) 		0.99
(1.00) 		0.892
(1.00) 		0.582
(1.00) 		0.124
(0.771) 		0.486
(0.997) 		0.584
(1.00) 		0.447
(0.994) 		0.501
(0.997) 		0.799
(1.00) 		0.864
(1.00) 		0.775
(1.00) 		0.52
(0.997) 		0.393
(0.97) 		0.397
(0.97) 		0.39
(0.97)
10q loss 74 (25%) 221 0.381
(0.97) 		0.0187
(0.586) 		0.542
(0.997) 		0.0559
(0.655) 		0.686
(1.00) 		0.849
(1.00) 		0.373
(0.97) 		0.744
(1.00) 		0.0222
(0.607) 		0.0316
(0.607) 		0.801
(1.00) 		0.885
(1.00) 		0.154
(0.806) 		0.00043
(0.185) 		0.835
(1.00) 		0.744
(1.00) 		0.157
(0.806) 		0.264
(0.906) 		1
(1.00) 		0.149
(0.806) 		0.67
(1.00) 		0.244
(0.895) 		0.0747
(0.719) 		0.77
(1.00) 		0.476
(0.996) 		0.00563
(0.456) 		0.226
(0.881) 		0.0537
(0.645) 		0.0222
(0.607) 		0.575
(1.00) 		0.438
(0.994) 		0.214
(0.868) 		0.809
(1.00) 		0.0968
(0.745) 		1
(1.00) 		0.805
(1.00) 		0.526
(0.997) 		0.023
(0.607) 		0.512
(0.997)
16q loss 44 (15%) 251 0.815
(1.00) 		0.174
(0.821) 		0.668
(1.00) 		0.0139
(0.544) 		1
(1.00) 		0.822
(1.00) 		8e-05
(0.137) 		0.382
(0.97) 		0.0713
(0.715) 		0.191
(0.835) 		0.743
(1.00) 		0.735
(1.00) 		0.695
(1.00) 		0.152
(0.806) 		0.846
(1.00) 		0.382
(0.97) 		0.375
(0.97) 		0.423
(0.993) 		1
(1.00) 		0.226
(0.881) 		0.93
(1.00) 		0.983
(1.00) 		0.494
(0.997) 		0.292
(0.93) 		0.52
(0.997) 		0.95
(1.00) 		0.437
(0.994) 		0.815
(1.00) 		0.0713
(0.715) 		0.507
(0.997) 		0.0561
(0.655) 		0.271
(0.918) 		1
(1.00) 		0.302
(0.936) 		0.463
(0.994) 		0.664
(1.00) 		0.136
(0.798) 		0.884
(1.00)
18q loss 73 (25%) 222 0.594
(1.00) 		0.875
(1.00) 		0.618
(1.00) 		0.124
(0.771) 		0.456
(0.994) 		0.707
(1.00) 		0.00028
(0.185) 		0.263
(0.906) 		0.04
(0.607) 		0.987
(1.00) 		0.789
(1.00) 		0.222
(0.878) 		0.342
(0.967) 		0.574
(1.00) 		0.429
(0.994) 		0.263
(0.906) 		0.344
(0.967) 		0.475
(0.995) 		1
(1.00) 		0.0966
(0.745) 		0.166
(0.821) 		0.845
(1.00) 		0.131
(0.791) 		0.925
(1.00) 		0.864
(1.00) 		0.429
(0.994) 		0.59
(1.00) 		0.101
(0.753) 		0.04
(0.607) 		0.364
(0.97) 		1
(1.00) 		0.0364
(0.607) 		0.263
(0.906) 		0.645
(1.00) 		0.0113
(0.525) 		0.0806
(0.72) 		0.824
(1.00) 		0.0829
(0.729)
19p loss 60 (20%) 235 0.000386
(0.185) 		0.488
(0.997) 		0.342
(0.967) 		0.199
(0.846) 		1
(1.00) 		1
(1.00) 		0.703
(1.00) 		0.214
(0.868) 		0.181
(0.83) 		0.228
(0.888) 		0.258
(0.906) 		0.613
(1.00) 		0.00564
(0.456) 		0.293
(0.93) 		0.428
(0.994) 		0.214
(0.868) 		0.925
(1.00) 		0.117
(0.771) 		0.551
(0.997) 		0.481
(0.997) 		0.216
(0.869) 		0.688
(1.00) 		0.695
(1.00) 		0.778
(1.00) 		0.816
(1.00) 		1
(1.00) 		0.398
(0.97) 		0.827
(1.00) 		0.181
(0.83) 		0.914
(1.00) 		1
(1.00) 		0.172
(0.821) 		0.561
(1.00) 		0.0258
(0.607) 		0.331
(0.959) 		0.287
(0.93) 		0.282
(0.928) 		0.526
(0.997) 		0.963
(1.00)
20q loss 10 (3%) 285 0.000745
(0.185) 		0.0598
(0.666) 		0.535
(0.997) 		0.325
(0.953) 		0.302
(0.936) 		1
(1.00) 		0.747
(1.00) 		0.0499
(0.634) 		0.13
(0.79) 		0.385
(0.97) 		1
(1.00) 		0.033
(0.607) 		0.036
(0.607) 		0.314
(0.943) 		0.0499
(0.634) 		0.296
(0.931) 		0.578
(1.00) 		0.759
(1.00) 		0.686
(1.00) 		0.11
(0.771) 		0.471
(0.994) 		0.724
(1.00) 		0.552
(0.997) 		0.0768
(0.719) 		1
(1.00) 		0.13
(0.79) 		0.712
(1.00) 		0.0776
(0.719) 		0.895
(1.00) 		0.411
(0.983) 		0.372
(0.97) 		0.302
(0.936) 		1
(1.00) 		0.0567
(0.655) 		0.982
(1.00)
1p gain 90 (31%) 205 0.89
(1.00) 		0.0112
(0.525) 		0.121
(0.771) 		0.727
(1.00) 		1
(1.00) 		1
(1.00) 		0.0383
(0.607) 		0.169
(0.821) 		0.183
(0.83) 		0.152
(0.806) 		1
(1.00) 		0.507
(0.997) 		1
(1.00) 		0.173
(0.821) 		0.869
(1.00) 		0.169
(0.821) 		0.392
(0.97) 		0.466
(0.994) 		1
(1.00) 		0.0954
(0.745) 		0.299
(0.935) 		0.805
(1.00) 		0.253
(0.904) 		0.522
(0.997) 		0.419
(0.993) 		0.566
(1.00) 		0.0128
(0.534) 		0.72
(1.00) 		0.183
(0.83) 		0.884
(1.00) 		1
(1.00) 		0.598
(1.00) 		0.155
(0.806) 		0.04
(0.607) 		0.405
(0.976) 		1
(1.00) 		0.136
(0.798) 		0.00934
(0.525) 		0.146
(0.806)
1q gain 140 (47%) 155 0.564
(1.00) 		0.3
(0.936) 		0.155
(0.806) 		0.75
(1.00) 		0.322
(0.951) 		0.748
(1.00) 		0.14
(0.798) 		0.546
(0.997) 		0.646
(1.00) 		0.0124
(0.528) 		0.826
(1.00) 		0.186
(0.83) 		1
(1.00) 		0.306
(0.94) 		0.85
(1.00) 		0.546
(0.997) 		0.536
(0.997) 		0.993
(1.00) 		1
(1.00) 		0.393
(0.97) 		0.256
(0.905) 		0.293
(0.93) 		0.624
(1.00) 		0.918
(1.00) 		0.116
(0.771) 		0.321
(0.949) 		0.157
(0.806) 		0.405
(0.976) 		0.646
(1.00) 		0.819
(1.00) 		0.399
(0.97) 		0.878
(1.00) 		0.418
(0.992) 		0.0307
(0.607) 		0.8
(1.00) 		0.218
(0.87) 		0.291
(0.93) 		0.244
(0.895) 		0.831
(1.00)
2p gain 64 (22%) 231 0.682
(1.00) 		0.457
(0.994) 		0.621
(1.00) 		1
(1.00) 		0.44
(0.994) 		0.181
(0.83) 		0.761
(1.00) 		0.171
(0.821) 		1
(1.00) 		0.449
(0.994) 		1
(1.00) 		0.0343
(0.607) 		0.0699
(0.71) 		0.573
(1.00) 		0.284
(0.928) 		0.171
(0.821) 		0.898
(1.00) 		0.595
(1.00) 		1
(1.00) 		0.58
(1.00) 		0.245
(0.895) 		0.565
(1.00) 		0.356
(0.97) 		0.569
(1.00) 		0.109
(0.77) 		0.887
(1.00) 		0.982
(1.00) 		0.532
(0.997) 		1
(1.00) 		0.88
(1.00) 		0.826
(1.00) 		0.724
(1.00) 		0.618
(1.00) 		0.8
(1.00) 		0.107
(0.768) 		0.366
(0.97) 		0.424
(0.993) 		0.338
(0.964)
2q gain 37 (13%) 258 0.498
(0.997) 		0.824
(1.00) 		0.579
(1.00) 		0.0793
(0.719) 		0.614
(1.00) 		0.0541
(0.645) 		0.666
(1.00) 		0.473
(0.994) 		0.0587
(0.658) 		0.923
(1.00) 		1
(1.00) 		0.0741
(0.719) 		0.155
(0.806) 		0.434
(0.994) 		0.0529
(0.645) 		0.473
(0.994) 		0.598
(1.00) 		0.434
(0.994) 		1
(1.00) 		0.154
(0.806) 		0.4
(0.971) 		0.447
(0.994) 		0.125
(0.771) 		0.95
(1.00) 		0.0575
(0.658) 		0.468
(0.994) 		0.841
(1.00) 		0.0371
(0.607) 		0.0587
(0.658) 		0.54
(0.997) 		1
(1.00) 		0.678
(1.00) 		0.43
(0.994) 		0.541
(0.997) 		0.0796
(0.719) 		0.426
(0.993) 		0.74
(1.00) 		0.831
(1.00)
3p gain 71 (24%) 224 0.0282
(0.607) 		0.455
(0.994) 		0.395
(0.97) 		1
(1.00) 		0.234
(0.895) 		0.852
(1.00) 		0.764
(1.00) 		0.155
(0.806) 		0.991
(1.00) 		0.472
(0.994) 		1
(1.00) 		0.317
(0.943) 		0.0104
(0.525) 		0.159
(0.806) 		0.989
(1.00) 		0.155
(0.806) 		0.988
(1.00) 		0.476
(0.996) 		0.536
(0.997) 		0.639
(1.00) 		0.647
(1.00) 		0.894
(1.00) 		0.314
(0.943) 		0.685
(1.00) 		0.188
(0.832) 		0.281
(0.927) 		0.313
(0.943) 		0.836
(1.00) 		0.991
(1.00) 		0.682
(1.00) 		0.843
(1.00) 		0.125
(0.771) 		1
(1.00) 		0.662
(1.00) 		1
(1.00) 		0.368
(0.97) 		0.157
(0.806) 		0.49
(0.997) 		0.489
(0.997)
3q gain 175 (59%) 120 0.427
(0.994) 		0.957
(1.00) 		0.433
(0.994) 		0.0218
(0.607) 		1
(1.00) 		0.512
(0.997) 		0.0104
(0.525) 		0.17
(0.821) 		0.0173
(0.586) 		0.232
(0.895) 		0.377
(0.97) 		0.103
(0.761) 		0.78
(1.00) 		0.732
(1.00) 		0.807
(1.00) 		0.17
(0.821) 		0.763
(1.00) 		0.426
(0.994) 		1
(1.00) 		0.352
(0.97) 		0.617
(1.00) 		0.907
(1.00) 		0.67
(1.00) 		0.488
(0.997) 		0.928
(1.00) 		0.616
(1.00) 		0.344
(0.967) 		0.241
(0.895) 		0.0173
(0.586) 		0.965
(1.00) 		0.731
(1.00) 		0.183
(0.83) 		0.581
(1.00) 		0.619
(1.00) 		0.796
(1.00) 		0.0174
(0.586) 		0.155
(0.806) 		0.961
(1.00) 		0.184
(0.83)
4p gain 11 (4%) 284 0.874
(1.00) 		0.349
(0.97) 		0.678
(1.00) 		0.677
(1.00) 		1
(1.00) 		1
(1.00) 		0.45
(0.994) 		0.605
(1.00) 		0.338
(0.964) 		0.242
(0.895) 		1
(1.00) 		0.967
(1.00) 		1
(1.00) 		0.386
(0.97) 		0.605
(1.00) 		1
(1.00) 		1
(1.00) 		0.44
(0.994) 		0.686
(1.00) 		0.216
(0.869) 		0.263
(0.906) 		0.724
(1.00) 		0.552
(0.997) 		0.878
(1.00) 		1
(1.00) 		0.338
(0.964) 		0.494
(0.997) 		1
(1.00) 		0.222
(0.878) 		1
(1.00) 		0.8
(1.00) 		1
(1.00) 		0.185
(0.83) 		0.354
(0.97) 		0.547
(0.997)
4q gain 16 (5%) 279 0.448
(0.994) 		0.756
(1.00) 		0.941
(1.00) 		1
(1.00) 		0.471
(0.994) 		0.461
(0.994) 		0.457
(0.994) 		0.313
(0.943) 		0.441
(0.994) 		0.63
(1.00) 		1
(1.00) 		0.949
(1.00) 		1
(1.00) 		0.511
(0.997) 		0.313
(0.943) 		0.874
(1.00) 		0.809
(1.00) 		0.506
(0.997) 		0.686
(1.00) 		0.216
(0.869) 		0.568
(1.00) 		0.724
(1.00) 		0.552
(0.997) 		0.828
(1.00) 		0.564
(1.00) 		0.495
(0.997) 		0.441
(0.994) 		0.987
(1.00) 		0.107
(0.768) 		0.45
(0.994) 		0.684
(1.00) 		0.955
(1.00) 		0.589
(1.00) 		1
(1.00) 		0.744
(1.00) 		0.668
(1.00)
5p gain 113 (38%) 182 0.888
(1.00) 		0.923
(1.00) 		0.116
(0.771) 		1
(1.00) 		0.0861
(0.734) 		0.246
(0.896) 		0.0266
(0.607) 		0.0419
(0.607) 		0.849
(1.00) 		0.397
(0.97) 		0.0377
(0.607) 		0.884
(1.00) 		0.67
(1.00) 		0.105
(0.765) 		0.813
(1.00) 		0.0419
(0.607) 		0.883
(1.00) 		0.565
(1.00) 		0.53
(0.997) 		0.0704
(0.713) 		0.386
(0.97) 		0.807
(1.00) 		0.0187
(0.586) 		0.123
(0.771) 		0.285
(0.929) 		0.804
(1.00) 		0.342
(0.967) 		0.856
(1.00) 		0.849
(1.00) 		0.0413
(0.607) 		0.299
(0.936) 		0.434
(0.994) 		0.818
(1.00) 		0.862
(1.00) 		0.777
(1.00) 		0.0584
(0.658) 		0.665
(1.00) 		0.806
(1.00) 		0.00738
(0.511)
5q gain 44 (15%) 251 0.727
(1.00) 		0.754
(1.00) 		0.0711
(0.715) 		0.809
(1.00) 		0.357
(0.97) 		0.491
(0.997) 		0.574
(1.00) 		0.17
(0.821) 		0.38
(0.97) 		0.679
(1.00) 		1
(1.00) 		0.682
(1.00) 		1
(1.00) 		0.652
(1.00) 		0.834
(1.00) 		0.17
(0.821) 		0.962
(1.00) 		0.837
(1.00) 		1
(1.00) 		0.315
(0.943) 		0.816
(1.00) 		0.548
(0.997) 		0.305
(0.937) 		0.574
(1.00) 		0.166
(0.821) 		0.795
(1.00) 		0.0609
(0.671) 		0.445
(0.994) 		0.38
(0.97) 		0.839
(1.00) 		0.466
(0.994) 		0.22
(0.872) 		0.723
(1.00) 		0.834
(1.00) 		0.12
(0.771) 		1
(1.00) 		0.571
(1.00) 		0.794
(1.00) 		0.643
(1.00)
6p gain 52 (18%) 243 0.243
(0.895) 		0.328
(0.955) 		0.974
(1.00) 		0.201
(0.851) 		0.677
(1.00) 		0.675
(1.00) 		0.685
(1.00) 		0.293
(0.93) 		0.32
(0.946) 		0.885
(1.00) 		0.773
(1.00) 		0.563
(1.00) 		0.114
(0.771) 		0.0518
(0.64) 		0.876
(1.00) 		0.293
(0.93) 		0.49
(0.997) 		0.523
(0.997) 		0.53
(0.997) 		0.474
(0.994) 		0.8
(1.00) 		0.295
(0.931) 		0.257
(0.906) 		0.834
(1.00) 		0.668
(1.00) 		0.896
(1.00) 		0.87
(1.00) 		0.375
(0.97) 		0.32
(0.946) 		0.729
(1.00) 		1
(1.00) 		0.158
(0.806) 		0.139
(0.798) 		0.285
(0.929) 		0.294
(0.93) 		0.232
(0.895) 		0.562
(1.00) 		0.353
(0.97) 		0.159
(0.806)
6q gain 36 (12%) 259 0.0334
(0.607) 		0.485
(0.997) 		0.206
(0.855) 		0.618
(1.00) 		1
(1.00) 		1
(1.00) 		0.33
(0.959) 		0.264
(0.906) 		0.916
(1.00) 		1
(1.00) 		0.16
(0.806) 		0.242
(0.895) 		0.0301
(0.607) 		0.0909
(0.743) 		0.44
(0.994) 		0.264
(0.906) 		0.736
(1.00) 		0.41
(0.983) 		0.551
(0.997) 		0.153
(0.806) 		0.934
(1.00) 		0.605
(1.00) 		0.255
(0.905) 		0.944
(1.00) 		0.473
(0.994) 		0.886
(1.00) 		1
(1.00) 		0.789
(1.00) 		0.916
(1.00) 		0.449
(0.994) 		0.583
(1.00) 		0.465
(0.994) 		0.266
(0.908) 		0.471
(0.994) 		0.209
(0.857) 		0.396
(0.97) 		0.958
(1.00) 		0.513
(0.997) 		0.465
(0.994)
7p gain 38 (13%) 257 0.498
(0.997) 		0.147
(0.806) 		0.00554
(0.456) 		1
(1.00) 		0.0646
(0.685) 		0.25
(0.9) 		0.875
(1.00) 		0.0258
(0.607) 		0.351
(0.97) 		0.749
(1.00) 		0.487
(0.997) 		0.907
(1.00) 		0.104
(0.761) 		0.55
(0.997) 		0.834
(1.00) 		0.0258
(0.607) 		0.604
(1.00) 		0.0757
(0.719) 		0.382
(0.97) 		0.117
(0.771) 		0.69
(1.00) 		0.689
(1.00) 		0.0364
(0.607) 		0.536
(0.997) 		0.763
(1.00) 		0.172
(0.821) 		0.399
(0.97) 		0.13
(0.79) 		0.351
(0.97) 		0.962
(1.00) 		1
(1.00) 		0.393
(0.97) 		0.91
(1.00) 		0.466
(0.994) 		0.667
(1.00) 		1
(1.00) 		0.161
(0.806) 		0.0297
(0.607)
7q gain 37 (13%) 258 0.9
(1.00) 		0.0408
(0.607) 		0.00279
(0.372) 		0.594
(1.00) 		0.08
(0.72) 		0.153
(0.806) 		0.737
(1.00) 		0.16
(0.806) 		0.552
(0.997) 		0.477
(0.997) 		0.711
(1.00) 		0.486
(0.997) 		0.541
(0.997) 		0.497
(0.997) 		0.253
(0.905) 		0.16
(0.806) 		0.18
(0.83) 		0.256
(0.905) 		0.53
(0.997) 		0.9
(1.00) 		0.754
(1.00) 		0.552
(0.997) 		0.396
(0.97) 		0.205
(0.855) 		0.184
(0.83) 		0.632
(1.00) 		0.46
(0.994) 		0.368
(0.97) 		0.552
(0.997) 		0.843
(1.00) 		1
(1.00) 		0.113
(0.771) 		1
(1.00) 		0.988
(1.00) 		1
(1.00) 		1
(1.00) 		0.0457
(0.617) 		0.506
(0.997)
8p gain 53 (18%) 242 0.435
(0.994) 		0.134
(0.795) 		0.0288
(0.607) 		0.548
(0.997) 		0.103
(0.758) 		0.0239
(0.607) 		0.176
(0.826) 		0.529
(0.997) 		0.73
(1.00) 		0.681
(1.00) 		1
(1.00) 		0.919
(1.00) 		0.857
(1.00) 		0.671
(1.00) 		0.549
(0.997) 		0.529
(0.997) 		0.203
(0.855) 		0.977
(1.00) 		1
(1.00) 		0.102
(0.758) 		0.369
(0.97) 		0.98
(1.00) 		0.37
(0.97) 		0.0487
(0.628) 		0.602
(1.00) 		0.449
(0.994) 		0.296
(0.931) 		0.506
(0.997) 		0.73
(1.00) 		0.241
(0.895) 		0.84
(1.00) 		0.571
(1.00) 		0.148
(0.806) 		0.456
(0.994) 		1
(1.00) 		1
(1.00) 		0.61
(1.00) 		0.118
(0.771) 		0.827
(1.00)
9p gain 49 (17%) 246 0.632
(1.00) 		0.0554
(0.651) 		0.0768
(0.719) 		0.0785
(0.719) 		1
(1.00) 		0.68
(1.00) 		0.948
(1.00) 		0.267
(0.909) 		0.159
(0.806) 		0.0728
(0.719) 		0.304
(0.937) 		0.875
(1.00) 		0.35
(0.97) 		0.689
(1.00) 		0.352
(0.97) 		0.267
(0.909) 		0.158
(0.806) 		0.546
(0.997) 		1
(1.00) 		0.703
(1.00) 		0.888
(1.00) 		0.0977
(0.745) 		0.0392
(0.607) 		0.47
(0.994) 		0.0865
(0.734) 		0.763
(1.00) 		0.675
(1.00) 		0.818
(1.00) 		0.159
(0.806) 		0.394
(0.97) 		0.0491
(0.628) 		0.286
(0.93) 		0.891
(1.00) 		0.741
(1.00) 		0.21
(0.857) 		0.236
(0.895) 		0.85
(1.00) 		0.0489
(0.628) 		0.258
(0.906)
10p gain 25 (8%) 270 0.379
(0.97) 		0.748
(1.00) 		0.0773
(0.719) 		0.0892
(0.739) 		1
(1.00) 		0.779
(1.00) 		0.661
(1.00) 		0.721
(1.00) 		0.0325
(0.607) 		0.938
(1.00) 		0.474
(0.994) 		0.195
(0.838) 		0.621
(1.00) 		0.84
(1.00) 		0.39
(0.97) 		0.721
(1.00) 		0.145
(0.806) 		0.0429
(0.607) 		1
(1.00) 		0.915
(1.00) 		0.515
(0.997) 		0.91
(1.00) 		0.414
(0.987) 		0.423
(0.993) 		0.271
(0.918) 		0.886
(1.00) 		0.95
(1.00) 		0.368
(0.97) 		0.0325
(0.607) 		0.691
(1.00) 		0.144
(0.806) 		0.207
(0.855) 		0.65
(1.00) 		0.361
(0.97) 		0.688
(1.00) 		0.387
(0.97) 		0.775
(1.00) 		0.77
(1.00)
10q gain 17 (6%) 278 0.949
(1.00) 		0.889
(1.00) 		0.22
(0.872) 		0.19
(0.832) 		1
(1.00) 		0.507
(0.997) 		0.468
(0.994) 		0.184
(0.83) 		0.256
(0.905) 		0.932
(1.00) 		0.174
(0.821) 		0.246
(0.896) 		1
(1.00) 		0.531
(0.997) 		0.633
(1.00) 		0.184
(0.83) 		0.15
(0.806) 		0.352
(0.97) 		1
(1.00) 		0.68
(1.00) 		0.589
(1.00) 		0.697
(1.00) 		0.435
(0.994) 		0.613
(1.00) 		0.132
(0.794) 		1
(1.00) 		0.643
(1.00) 		1
(1.00) 		0.256
(0.905) 		0.851
(1.00) 		0.724
(1.00) 		0.37
(0.97) 		0.272
(0.919) 		0.0518
(0.64) 		1
(1.00) 		1
(1.00) 		0.871
(1.00) 		0.763
(1.00)
11p gain 9 (3%) 286 0.985
(1.00) 		0.116
(0.771) 		0.175
(0.823) 		0.639
(1.00) 		0.302
(0.936) 		1
(1.00) 		0.522
(0.997) 		0.204
(0.855) 		1
(1.00) 		0.415
(0.987) 		0.209
(0.857) 		0.693
(1.00) 		0.742
(1.00) 		0.131
(0.791) 		1
(1.00) 		0.421
(0.993) 		0.766
(1.00) 		0.967
(1.00) 		0.572
(1.00) 		0.158
(0.806) 		0.677
(1.00) 		0.204
(0.855) 		0.754
(1.00) 		1
(1.00) 		0.496
(0.997) 		0.0409
(0.607) 		0.741
(1.00) 		1
(1.00) 		0.0839
(0.73) 		0.112
(0.771) 		0.503
(0.997)
11q gain 8 (3%) 287 0.532
(0.997) 		0.326
(0.953) 		0.664
(1.00) 		0.369
(0.97) 		0.302
(0.936) 		1
(1.00) 		0.466
(0.994) 		0.033
(0.607) 		0.779
(1.00) 		0.489
(0.997) 		0.693
(1.00) 		0.676
(1.00) 		0.0345
(0.607) 		0.0967
(0.745) 		1
(1.00) 		0.332
(0.959) 		0.789
(1.00) 		0.496
(0.997) 		0.572
(1.00) 		0.187
(0.831) 		1
(1.00) 		0.033
(0.607) 		0.347
(0.97) 		1
(1.00) 		0.252
(0.902) 		0.792
(1.00) 		1
(1.00) 		0.107
(0.768) 		0.317
(0.943) 		0.589
(1.00)
12p gain 53 (18%) 242 0.836
(1.00) 		0.0794
(0.719) 		0.134
(0.795) 		1
(1.00) 		0.117
(0.771) 		0.681
(1.00) 		0.942
(1.00) 		0.023
(0.607) 		0.845
(1.00) 		0.716
(1.00) 		0.771
(1.00) 		0.398
(0.97) 		1
(1.00) 		0.495
(0.997) 		0.792
(1.00) 		0.023
(0.607) 		0.123
(0.771) 		0.486
(0.997) 		0.551
(0.997) 		0.0407
(0.607) 		0.888
(1.00) 		0.676
(1.00) 		0.0652
(0.688) 		0.404
(0.976) 		0.198
(0.845) 		0.704
(1.00) 		0.669
(1.00) 		0.524
(0.997) 		0.845
(1.00) 		0.358
(0.97) 		0.0294
(0.607) 		0.73
(1.00) 		0.691
(1.00) 		0.858
(1.00) 		1
(1.00) 		1
(1.00) 		0.692
(1.00) 		0.0916
(0.743) 		0.435
(0.994)
12q gain 50 (17%) 245 0.806
(1.00) 		0.0938
(0.744) 		0.344
(0.967) 		0.688
(1.00) 		0.407
(0.979) 		0.834
(1.00) 		0.839
(1.00) 		0.157
(0.806) 		0.979
(1.00) 		0.766
(1.00) 		0.764
(1.00) 		0.238
(0.895) 		0.587
(1.00) 		0.0391
(0.607) 		0.684
(1.00) 		0.157
(0.806) 		0.168
(0.821) 		0.443
(0.994) 		0.536
(0.997) 		0.0109
(0.525) 		0.983
(1.00) 		0.938
(1.00) 		0.0243
(0.607) 		0.709
(1.00) 		0.0208
(0.607) 		1
(1.00) 		0.343
(0.967) 		1
(1.00) 		0.979
(1.00) 		0.973
(1.00) 		0.088
(0.737) 		0.946
(1.00) 		0.746
(1.00) 		0.549
(0.997) 		0.51
(0.997) 		0.731
(1.00) 		0.225
(0.881) 		0.109
(0.769) 		0.53
(0.997)
13q gain 24 (8%) 271 0.0249
(0.607) 		0.826
(1.00) 		0.638
(1.00) 		0.78
(1.00) 		0.596
(1.00) 		0.779
(1.00) 		0.0393
(0.607) 		0.624
(1.00) 		0.587
(1.00) 		0.938
(1.00) 		0.223
(0.878) 		0.424
(0.993) 		0.122
(0.771) 		0.967
(1.00) 		0.624
(1.00) 		0.554
(0.998) 		0.312
(0.943) 		1
(1.00) 		0.499
(0.997) 		0.453
(0.994) 		0.451
(0.994) 		0.85
(1.00) 		0.229
(0.89) 		1
(1.00) 		1
(1.00) 		0.701
(1.00) 		1
(1.00) 		0.587
(1.00) 		0.378
(0.97) 		0.51
(0.997) 		0.432
(0.994) 		0.552
(0.997) 		0.833
(1.00) 		0.351
(0.97) 		0.133
(0.795) 		0.849
(1.00) 		0.583
(1.00)
14q gain 47 (16%) 248 0.823
(1.00) 		0.572
(1.00) 		0.333
(0.959) 		0.821
(1.00) 		1
(1.00) 		1
(1.00) 		0.724
(1.00) 		0.173
(0.821) 		0.383
(0.97) 		0.568
(1.00) 		0.568
(1.00) 		0.125
(0.771) 		0.576
(1.00) 		0.655
(1.00) 		0.343
(0.967) 		0.173
(0.821) 		0.157
(0.806) 		0.933
(1.00) 		1
(1.00) 		0.0617
(0.674) 		0.277
(0.927) 		0.367
(0.97) 		0.104
(0.761) 		0.123
(0.771) 		0.411
(0.983) 		0.885
(1.00) 		0.423
(0.993) 		1
(1.00) 		0.383
(0.97) 		0.781
(1.00) 		0.49
(0.997) 		0.279
(0.927) 		0.0451
(0.617) 		0.974
(1.00) 		0.734
(1.00) 		0.715
(1.00) 		0.95
(1.00) 		0.534
(0.997) 		0.757
(1.00)
15q gain 52 (18%) 243 0.945
(1.00) 		0.0581
(0.658) 		0.0451
(0.617) 		0.832
(1.00) 		0.205
(0.855) 		0.14
(0.801) 		0.0503
(0.636) 		0.119
(0.771) 		0.872
(1.00) 		0.292
(0.93) 		0.776
(1.00) 		0.518
(0.997) 		0.587
(1.00) 		0.374
(0.97) 		0.291
(0.93) 		0.119
(0.771) 		0.653
(1.00) 		0.865
(1.00) 		1
(1.00) 		0.057
(0.656) 		0.461
(0.994) 		0.543
(0.997) 		0.123
(0.771) 		0.832
(1.00) 		0.734
(1.00) 		0.849
(1.00) 		0.214
(0.868) 		0.83
(1.00) 		0.872
(1.00) 		0.926
(1.00) 		0.64
(1.00) 		0.729
(1.00) 		0.484
(0.997) 		0.837
(1.00) 		1
(1.00) 		1
(1.00) 		0.0505
(0.636) 		0.278
(0.927)
16p gain 44 (15%) 251 0.953
(1.00) 		0.77
(1.00) 		0.203
(0.855) 		0.277
(0.927) 		0.686
(1.00) 		0.819
(1.00) 		0.974
(1.00) 		0.873
(1.00) 		0.0698
(0.71) 		0.324
(0.952) 		0.747
(1.00) 		0.697
(1.00) 		0.695
(1.00) 		0.602
(1.00) 		0.107
(0.768) 		0.873
(1.00) 		0.0949
(0.745) 		0.906
(1.00) 		1
(1.00) 		0.0271
(0.607) 		0.93
(1.00) 		0.391
(0.97) 		0.247
(0.898) 		0.874
(1.00) 		0.00706
(0.511) 		0.887
(1.00) 		0.776
(1.00) 		1
(1.00) 		0.0698
(0.71) 		0.396
(0.97) 		0.175
(0.822) 		0.575
(1.00) 		0.532
(0.997) 		0.922
(1.00) 		0.24
(0.895) 		0.425
(0.993) 		0.817
(1.00) 		0.672
(1.00)
16q gain 40 (14%) 255 0.628
(1.00) 		0.825
(1.00) 		0.101
(0.753) 		0.647
(1.00) 		0.208
(0.857) 		0.819
(1.00) 		0.794
(1.00) 		0.819
(1.00) 		0.28
(0.927) 		0.29
(0.93) 		1
(1.00) 		0.316
(0.943) 		0.236
(0.895) 		0.355
(0.97) 		0.107
(0.768) 		0.819
(1.00) 		0.113
(0.771) 		0.613
(1.00) 		1
(1.00) 		0.0172
(0.586) 		0.754
(1.00) 		0.434
(0.994) 		0.0373
(0.607) 		0.914
(1.00) 		0.0267
(0.607) 		0.895
(1.00) 		0.766
(1.00) 		0.625
(1.00) 		0.28
(0.927) 		0.354
(0.97) 		0.249
(0.9) 		0.479
(0.997) 		1
(1.00) 		0.698
(1.00) 		1
(1.00) 		0.37
(0.97) 		0.783
(1.00) 		0.0801
(0.72)
17p gain 22 (7%) 273 0.539
(0.997) 		0.18
(0.83) 		0.00215
(0.299) 		0.173
(0.821) 		0.235
(0.895) 		0.231
(0.895) 		0.769
(1.00) 		0.0776
(0.719) 		0.0439
(0.61) 		0.602
(1.00) 		0.36
(0.97) 		0.593
(1.00) 		0.608
(1.00) 		0.533
(0.997) 		0.304
(0.937) 		0.0776
(0.719) 		0.327
(0.953) 		0.1
(0.753) 		1
(1.00) 		0.0113
(0.525) 		0.515
(0.997) 		0.468
(0.994) 		0.21
(0.858) 		0.11
(0.771) 		0.1
(0.753) 		0.535
(0.997) 		0.31
(0.943) 		0.495
(0.997) 		0.0439
(0.61) 		0.168
(0.821) 		0.452
(0.994) 		0.99
(1.00) 		0.649
(1.00) 		0.421
(0.993) 		0.615
(1.00) 		1
(1.00) 		0.194
(0.838) 		0.151
(0.806)
17q gain 42 (14%) 253 0.449
(0.994) 		0.522
(0.997) 		0.0194
(0.597) 		0.632
(1.00) 		1
(1.00) 		0.819
(1.00) 		0.171
(0.821) 		0.0477
(0.625) 		0.198
(0.845) 		0.714
(1.00) 		0.331
(0.959) 		0.399
(0.97) 		0.843
(1.00) 		0.028
(0.607) 		0.583
(1.00) 		0.0477
(0.625) 		0.0846
(0.73) 		0.466
(0.994) 		1
(1.00) 		0.00875
(0.518) 		0.377
(0.97) 		0.121
(0.771) 		0.0642
(0.685) 		0.243
(0.895) 		0.451
(0.994) 		0.864
(1.00) 		0.656
(1.00) 		0.473
(0.994) 		0.198
(0.845) 		0.679
(1.00) 		0.785
(1.00) 		0.576
(1.00) 		0.734
(1.00) 		0.0609
(0.671) 		0.294
(0.93) 		1
(1.00) 		0.396
(0.97) 		0.554
(0.998) 		0.0857
(0.734)
18p gain 49 (17%) 246 0.355
(0.97) 		0.0178
(0.586) 		0.046
(0.618) 		0.179
(0.83) 		1
(1.00) 		0.409
(0.983) 		0.0927
(0.743) 		0.84
(1.00) 		0.314
(0.943) 		0.971
(1.00) 		0.354
(0.97) 		0.124
(0.771) 		0.852
(1.00) 		0.105
(0.763) 		0.708
(1.00) 		0.84
(1.00) 		0.0864
(0.734) 		0.391
(0.97) 		1
(1.00) 		0.0874
(0.736) 		0.178
(0.83) 		0.155
(0.806) 		0.0259
(0.607) 		0.751
(1.00) 		0.52
(0.997) 		0.158
(0.806) 		0.81
(1.00) 		1
(1.00) 		0.314
(0.943) 		0.569
(1.00) 		1
(1.00) 		0.152
(0.806) 		0.367
(0.97) 		0.523
(0.997) 		0.709
(1.00) 		0.729
(1.00) 		0.61
(1.00) 		0.021
(0.607) 		0.328
(0.955)
18q gain 32 (11%) 263 0.873
(1.00) 		0.0367
(0.607) 		0.0185
(0.586) 		0.797
(1.00) 		1
(1.00) 		0.616
(1.00) 		0.216
(0.869) 		0.747
(1.00) 		0.99
(1.00) 		0.621
(1.00) 		0.264
(0.906) 		0.194
(0.838) 		1
(1.00) 		0.151
(0.806) 		0.833
(1.00) 		0.747
(1.00) 		0.0113
(0.525) 		0.274
(0.924) 		1
(1.00) 		0.164
(0.821) 		0.553
(0.997) 		0.26
(0.906) 		0.101
(0.753) 		0.954
(1.00) 		0.839
(1.00) 		0.0754
(0.719) 		0.684
(1.00) 		0.777
(1.00) 		0.99
(1.00) 		0.675
(1.00) 		0.798
(1.00) 		0.21
(0.857) 		1
(1.00) 		0.565
(1.00) 		0.639
(1.00) 		1
(1.00) 		0.61
(1.00) 		0.0414
(0.607) 		0.509
(0.997)
19p gain 44 (15%) 251 0.232
(0.895) 		0.665
(1.00) 		0.108
(0.769) 		0.124
(0.771) 		1
(1.00) 		0.511
(0.997) 		0.397
(0.97) 		0.217
(0.869) 		0.0979
(0.745) 		0.609
(1.00) 		0.207
(0.856) 		0.89
(1.00) 		0.447
(0.994) 		0.866
(1.00) 		0.498
(0.997) 		0.217
(0.869) 		0.00571
(0.456) 		0.936
(1.00) 		0.53
(0.997) 		0.171
(0.821) 		0.874
(1.00) 		0.137
(0.798) 		0.0546
(0.646) 		0.741
(1.00) 		0.149
(0.806) 		0.795
(1.00) 		0.789
(1.00) 		0.106
(0.765) 		0.0979
(0.745) 		0.0832
(0.729) 		0.0341
(0.607) 		0.821
(1.00) 		1
(1.00) 		0.606
(1.00) 		0.121
(0.771) 		1
(1.00) 		0.571
(1.00) 		0.601
(1.00) 		0.28
(0.927)
19q gain 72 (24%) 223 0.547
(0.997) 		0.25
(0.9) 		0.0541
(0.645) 		0.349
(0.97) 		0.114
(0.771) 		0.567
(1.00) 		0.556
(0.998) 		0.17
(0.821) 		0.455
(0.994) 		0.578
(1.00) 		0.0175
(0.586) 		0.739
(1.00) 		1
(1.00) 		0.59
(1.00) 		0.135
(0.797) 		0.17
(0.821) 		0.0403
(0.607) 		0.651
(1.00) 		0.543
(0.997) 		0.0277
(0.607) 		0.54
(0.997) 		0.175
(0.822) 		0.00462
(0.456) 		0.44
(0.994) 		0.233
(0.895) 		0.876
(1.00) 		0.842
(1.00) 		0.239
(0.895) 		0.455
(0.994) 		0.531
(0.997) 		0.0806
(0.72) 		0.308
(0.943) 		0.456
(0.994) 		0.399
(0.97) 		1
(1.00) 		1
(1.00) 		0.753
(1.00) 		0.28
(0.927) 		0.183
(0.83)
20p gain 100 (34%) 195 0.924
(1.00) 		0.0972
(0.745) 		0.00472
(0.456) 		0.0846
(0.73) 		0.497
(0.997) 		0.17
(0.821) 		0.788
(1.00) 		0.514
(0.997) 		0.0134
(0.534) 		0.16
(0.806) 		0.342
(0.967) 		0.267
(0.909) 		0.771
(1.00) 		0.382
(0.97) 		0.734
(1.00) 		0.514
(0.997) 		0.497
(0.997) 		0.803
(1.00) 		0.53
(0.997) 		0.262
(0.906) 		0.383
(0.97) 		0.511
(0.997) 		0.31
(0.943) 		0.705
(1.00) 		0.635
(1.00) 		0.717
(1.00) 		0.592
(1.00) 		0.598
(1.00) 		0.0134
(0.534) 		0.969
(1.00) 		0.581
(1.00) 		0.526
(0.997) 		0.743
(1.00) 		0.303
(0.937) 		1
(1.00) 		0.265
(0.906) 		0.95
(1.00) 		0.0946
(0.745) 		0.814
(1.00)
20q gain 115 (39%) 180 0.343
(0.967) 		0.0972
(0.745) 		0.0897
(0.741) 		0.511
(0.997) 		0.738
(1.00) 		0.404
(0.976) 		0.698
(1.00) 		0.96
(1.00) 		0.139
(0.798) 		0.111
(0.771) 		0.26
(0.906) 		0.153
(0.806) 		0.571
(1.00) 		0.439
(0.994) 		0.913
(1.00) 		0.96
(1.00) 		0.401
(0.973) 		0.75
(1.00) 		0.543
(0.997) 		0.477
(0.997) 		0.449
(0.994) 		0.492
(0.997) 		0.901
(1.00) 		0.527
(0.997) 		0.224
(0.881) 		0.47
(0.994) 		0.581
(1.00) 		0.613
(1.00) 		0.139
(0.798) 		0.784
(1.00) 		0.28
(0.927) 		0.659
(1.00) 		0.734
(1.00) 		0.502
(0.997) 		0.793
(1.00) 		0.233
(0.895) 		0.493
(0.997) 		0.072
(0.719) 		0.29
(0.93)
21q gain 37 (13%) 258 0.345
(0.967) 		0.0788
(0.719) 		0.315
(0.943) 		1
(1.00) 		0.614
(1.00) 		0.805
(1.00) 		0.726
(1.00) 		0.265
(0.906) 		0.825
(1.00) 		0.844
(1.00) 		0.73
(1.00) 		0.543
(0.997) 		0.0935
(0.744) 		0.475
(0.995) 		0.882
(1.00) 		0.265
(0.906) 		0.279
(0.927) 		0.421
(0.993) 		0.382
(0.97) 		0.646
(1.00) 		0.25
(0.9) 		0.952
(1.00) 		0.842
(1.00) 		0.534
(0.997) 		0.921
(1.00) 		0.349
(0.97) 		0.0625
(0.676) 		0.62
(1.00) 		0.825
(1.00) 		0.828
(1.00) 		0.0455
(0.617) 		0.454
(0.994) 		0.816
(1.00) 		0.639
(1.00) 		0.688
(1.00) 		0.577
(1.00) 		0.712
(1.00) 		0.0846
(0.73) 		0.371
(0.97)
22q gain 29 (10%) 266 0.255
(0.905) 		0.62
(1.00) 		0.714
(1.00) 		0.775
(1.00) 		1
(1.00) 		0.0375
(0.607) 		0.921
(1.00) 		0.778
(1.00) 		0.555
(0.998) 		0.201
(0.851) 		1
(1.00) 		0.389
(0.97) 		0.385
(0.97) 		0.628
(1.00) 		0.519
(0.997) 		0.778
(1.00) 		0.868
(1.00) 		0.348
(0.97) 		1
(1.00) 		0.544
(0.997) 		0.553
(0.997) 		0.391
(0.97) 		0.714
(1.00) 		0.765
(1.00) 		0.923
(1.00) 		0.466
(0.994) 		0.918
(1.00) 		1
(1.00) 		0.555
(0.998) 		0.725
(1.00) 		0.557
(0.999) 		0.834
(1.00) 		0.282
(0.928) 		1
(1.00) 		0.597
(1.00) 		1
(1.00) 		0.336
(0.961) 		0.589
(1.00) 		0.682
(1.00)
xq gain 42 (14%) 253 0.156
(0.806) 		0.865
(1.00) 		0.0242
(0.607) 		0.64
(1.00) 		1
(1.00) 		0.0689
(0.709) 		0.606
(1.00) 		0.392
(0.97) 		0.953
(1.00) 		0.285
(0.929) 		0.0835
(0.73) 		0.369
(0.97) 		1
(1.00) 		0.444
(0.994) 		0.0579
(0.658) 		0.392
(0.97) 		0.481
(0.997) 		0.581
(1.00) 		0.298
(0.934) 		0.162
(0.814) 		0.754
(1.00) 		0.251
(0.902) 		0.0184
(0.586) 		0.51
(0.997) 		0.63
(1.00) 		0.624
(1.00) 		0.424
(0.993) 		0.625
(1.00) 		0.953
(1.00) 		0.501
(0.997) 		0.459
(0.994) 		0.143
(0.806) 		0.0931
(0.743) 		0.379
(0.97) 		0.458
(0.994) 		1
(1.00) 		0.901
(1.00) 		0.825
(1.00)
1p loss 13 (4%) 282 0.481
(0.997) 		0.943
(1.00) 		0.115
(0.771) 		0.639
(1.00) 		0.081
(0.72) 		0.278
(0.927) 		0.914
(1.00) 		0.919
(1.00) 		0.865
(1.00) 		0.91
(1.00) 		0.26
(0.906) 		0.434
(0.994) 		0.304
(0.937) 		0.854
(1.00) 		0.919
(1.00) 		0.154
(0.806) 		0.744
(1.00) 		1
(1.00) 		0.0647
(0.685) 		0.589
(1.00) 		0.189
(0.832) 		0.166
(0.821) 		0.201
(0.851) 		0.524
(0.997) 		1
(1.00) 		0.36
(0.97) 		0.865
(1.00) 		0.794
(1.00) 		0.0776
(0.719) 		0.0727
(0.719) 		0.381
(0.97) 		0.894
(1.00) 		1
(1.00) 		0.156
(0.806) 		0.962
(1.00) 		0.404
(0.976)
1q loss 9 (3%) 286 0.559
(1.00) 		0.538
(0.997) 		0.388
(0.97) 		0.369
(0.97) 		0.302
(0.936) 		0.326
(0.953) 		0.705
(1.00) 		0.311
(0.943) 		0.257
(0.905) 		0.239
(0.895) 		1
(1.00) 		0.41
(0.983) 		0.72
(1.00) 		0.883
(1.00) 		0.311
(0.943) 		0.11
(0.771) 		0.664
(1.00) 		1
(1.00) 		0.0264
(0.607) 		0.55
(0.997) 		0.491
(0.997) 		0.235
(0.895) 		0.0511
(0.638) 		0.661
(1.00) 		1
(1.00) 		0.472
(0.994) 		0.677
(1.00) 		0.257
(0.905) 		0.12
(0.771) 		0.153
(0.806) 		0.0296
(0.607) 		0.22
(0.871) 		0.163
(0.818) 		1
(1.00) 		0.157
(0.806) 		0.523
(0.997) 		0.696
(1.00)
2p loss 19 (6%) 276 0.926
(1.00) 		0.479
(0.997) 		0.593
(1.00) 		0.516
(0.997) 		1
(1.00) 		0.757
(1.00) 		0.849
(1.00) 		0.977
(1.00) 		0.756
(1.00) 		0.646
(1.00) 		0.648
(1.00) 		0.397
(0.97) 		0.782
(1.00) 		0.819
(1.00) 		0.977
(1.00) 		0.238
(0.895) 		0.894
(1.00) 		1
(1.00) 		0.0307
(0.607) 		0.325
(0.953) 		0.115
(0.771) 		0.32
(0.947) 		0.0811
(0.72) 		0.197
(0.845) 		0.632
(1.00) 		1
(1.00) 		0.527
(0.997) 		0.756
(1.00) 		0.0176
(0.586) 		0.557
(0.999) 		0.575
(1.00) 		0.466
(0.994) 		0.953
(1.00) 		0.587
(1.00) 		1
(1.00) 		0.503
(0.997) 		0.538
(0.997)
2q loss 35 (12%) 260 0.373
(0.97) 		0.339
(0.964) 		0.736
(1.00) 		1
(1.00) 		0.354
(0.97) 		0.798
(1.00) 		0.875
(1.00) 		0.803
(1.00) 		0.715
(1.00) 		0.76
(1.00) 		0.743
(1.00) 		0.219
(0.87) 		0.668
(1.00) 		0.56
(1.00) 		0.981
(1.00) 		0.803
(1.00) 		0.284
(0.928) 		0.872
(1.00) 		1
(1.00) 		0.0534
(0.645) 		0.754
(1.00) 		0.256
(0.905) 		0.359
(0.97) 		0.0534
(0.645) 		0.684
(1.00) 		0.643
(1.00) 		0.443
(0.994) 		0.466
(0.994) 		0.715
(1.00) 		0.00428
(0.456) 		1
(1.00) 		0.934
(1.00) 		1
(1.00) 		0.344
(0.967) 		0.21
(0.857) 		0.608
(1.00) 		0.364
(0.97) 		0.356
(0.97)
3q loss 14 (5%) 281 0.618
(1.00) 		0.409
(0.982) 		0.584
(1.00) 		0.434
(0.994) 		1
(1.00) 		1
(1.00) 		0.46
(0.994) 		0.0132
(0.534) 		0.789
(1.00) 		0.784
(1.00) 		1
(1.00) 		0.252
(0.902) 		0.036
(0.607) 		0.614
(1.00) 		0.503
(0.997) 		0.0132
(0.534) 		0.488
(0.997) 		0.798
(1.00) 		0.719
(1.00) 		0.686
(1.00) 		0.814
(1.00) 		0.592
(1.00) 		0.285
(0.929) 		0.375
(0.97) 		0.551
(0.997) 		0.367
(0.97) 		0.789
(1.00) 		0.638
(1.00) 		1
(1.00) 		0.664
(1.00) 		0.676
(1.00) 		0.0918
(0.743) 		0.418
(0.992) 		0.0338
(0.607) 		0.421
(0.993) 		0.439
(0.994)
5p loss 19 (6%) 276 0.0355
(0.607) 		0.735
(1.00) 		0.0871
(0.735) 		0.0659
(0.691) 		1
(1.00) 		0.704
(1.00) 		0.513
(0.997) 		0.167
(0.821) 		0.0368
(0.607) 		1
(1.00) 		1
(1.00) 		0.679
(1.00) 		0.0992
(0.75) 		0.464
(0.994) 		0.167
(0.821) 		0.0531
(0.645) 		0.869
(1.00) 		0.459
(0.994) 		0.0917
(0.743) 		0.483
(0.997) 		0.656
(1.00) 		0.669
(1.00) 		0.0136
(0.536) 		0.898
(1.00) 		0.745
(1.00) 		0.537
(0.997) 		0.167
(0.821) 		0.0368
(0.607) 		0.695
(1.00) 		0.304
(0.937) 		0.194
(0.838) 		0.726
(1.00) 		0.929
(1.00) 		1
(1.00) 		0.185
(0.83) 		0.76
(1.00) 		0.255
(0.905)
5q loss 51 (17%) 244 0.184
(0.83) 		0.16
(0.806) 		0.242
(0.895) 		0.68
(1.00) 		1
(1.00) 		0.652
(1.00) 		0.544
(0.997) 		0.309
(0.943) 		0.0966
(0.745) 		0.701
(1.00) 		1
(1.00) 		0.264
(0.906) 		0.151
(0.806) 		0.551
(0.997) 		0.0487
(0.628) 		0.309
(0.943) 		0.157
(0.806) 		1
(1.00) 		1
(1.00) 		0.736
(1.00) 		0.216
(0.869) 		0.316
(0.943) 		0.465
(0.994) 		0.042
(0.607) 		0.734
(1.00) 		0.905
(1.00) 		0.656
(1.00) 		0.0588
(0.658) 		0.0966
(0.745) 		0.795
(1.00) 		0.528
(0.997) 		0.291
(0.93) 		0.441
(0.994) 		0.411
(0.983) 		0.738
(1.00) 		0.23
(0.895) 		0.0617
(0.674) 		0.188
(0.832) 		0.192
(0.836)
6p loss 47 (16%) 248 0.326
(0.953) 		0.453
(0.994) 		0.192
(0.835) 		0.492
(0.997) 		0.208
(0.857) 		1
(1.00) 		0.118
(0.771) 		0.809
(1.00) 		0.506
(0.997) 		0.387
(0.97) 		0.745
(1.00) 		0.546
(0.997) 		1
(1.00) 		0.673
(1.00) 		0.166
(0.821) 		0.809
(1.00) 		0.971
(1.00) 		0.898
(1.00) 		1
(1.00) 		0.118
(0.771) 		0.0259
(0.607) 		0.424
(0.993) 		0.232
(0.895) 		0.498
(0.997) 		0.994
(1.00) 		0.694
(1.00) 		0.385
(0.97) 		1
(1.00) 		0.506
(0.997) 		0.447
(0.994) 		0.345
(0.967) 		0.0729
(0.719) 		0.311
(0.943) 		0.452
(0.994) 		0.297
(0.933) 		0.712
(1.00) 		0.487
(0.997) 		0.984
(1.00)
6q loss 74 (25%) 221 0.0623
(0.675) 		0.983
(1.00) 		0.947
(1.00) 		0.56
(1.00) 		0.447
(0.994) 		0.247
(0.898) 		0.0879
(0.737) 		0.144
(0.806) 		0.585
(1.00) 		0.16
(0.806) 		0.603
(1.00) 		0.685
(1.00) 		0.624
(1.00) 		0.771
(1.00) 		0.0263
(0.607) 		0.144
(0.806) 		0.818
(1.00) 		0.323
(0.951) 		1
(1.00) 		0.274
(0.924) 		0.461
(0.994) 		0.702
(1.00) 		0.194
(0.838) 		0.803
(1.00) 		0.799
(1.00) 		1
(1.00) 		0.507
(0.997) 		1
(1.00) 		0.585
(1.00) 		0.794
(1.00) 		0.689
(1.00) 		0.0476
(0.625) 		0.923
(1.00) 		0.237
(0.895) 		1
(1.00) 		0.723
(1.00) 		0.961
(1.00) 		0.77
(1.00)
7p loss 26 (9%) 269 0.236
(0.895) 		0.0952
(0.745) 		0.363
(0.97) 		0.775
(1.00) 		0.599
(1.00) 		1
(1.00) 		0.732
(1.00) 		0.0795
(0.719) 		0.442
(0.994) 		0.158
(0.806) 		0.141
(0.806) 		0.0424
(0.607) 		0.159
(0.806) 		0.324
(0.952) 		0.633
(1.00) 		0.0795
(0.719) 		0.313
(0.943) 		0.862
(1.00) 		1
(1.00) 		0.335
(0.961) 		0.377
(0.97) 		0.361
(0.97) 		0.292
(0.93) 		0.24
(0.895) 		0.763
(1.00) 		0.243
(0.895) 		0.509
(0.997) 		0.78
(1.00) 		0.442
(0.994) 		0.451
(0.994) 		0.38
(0.97) 		0.674
(1.00) 		0.276
(0.927) 		0.769
(1.00) 		0.69
(1.00) 		0.509
(0.997) 		0.104
(0.761) 		0.499
(0.997)
7q loss 37 (13%) 258 0.156
(0.806) 		0.0232
(0.607) 		0.79
(1.00) 		0.452
(0.994) 		1
(1.00) 		1
(1.00) 		0.582
(1.00) 		0.206
(0.855) 		0.138
(0.798) 		0.636
(1.00) 		0.134
(0.795) 		0.579
(1.00) 		0.223
(0.878) 		0.414
(0.987) 		0.132
(0.795) 		0.206
(0.855) 		0.713
(1.00) 		0.425
(0.993) 		0.543
(0.997) 		0.334
(0.959) 		0.295
(0.931) 		0.256
(0.905) 		0.17
(0.821) 		0.148
(0.806) 		0.52
(0.997) 		0.242
(0.895) 		0.913
(1.00) 		0.348
(0.97) 		0.138
(0.798) 		0.902
(1.00) 		0.326
(0.953) 		0.473
(0.994) 		0.65
(1.00) 		0.383
(0.97) 		0.458
(0.994) 		0.449
(0.994) 		0.955
(1.00) 		0.021
(0.607) 		0.907
(1.00)
8q loss 24 (8%) 271 0.596
(1.00) 		0.377
(0.97) 		0.622
(1.00) 		0.239
(0.895) 		0.599
(1.00) 		0.0189
(0.586) 		0.12
(0.771) 		0.862
(1.00) 		0.283
(0.928) 		0.191
(0.835) 		1
(1.00) 		0.982
(1.00) 		0.324
(0.952) 		0.593
(1.00) 		0.862
(1.00) 		1
(1.00) 		0.835
(1.00) 		1
(1.00) 		0.79
(1.00) 		0.453
(0.994) 		0.965
(1.00) 		0.658
(1.00) 		0.654
(1.00) 		0.28
(0.927) 		0.897
(1.00) 		0.768
(1.00) 		0.394
(0.97) 		0.283
(0.928) 		0.696
(1.00) 		0.00772
(0.511) 		0.332
(0.959) 		0.0744
(0.719) 		0.447
(0.994) 		1
(1.00) 		1
(1.00) 		0.358
(0.97) 		0.174
(0.821)
9p loss 54 (18%) 241 0.499
(0.997) 		0.00635
(0.472) 		0.236
(0.895) 		1
(1.00) 		0.393
(0.97) 		1
(1.00) 		0.904
(1.00) 		0.744
(1.00) 		0.682
(1.00) 		0.749
(1.00) 		0.38
(0.97) 		0.207
(0.855) 		0.3
(0.936) 		0.754
(1.00) 		0.281
(0.927) 		0.744
(1.00) 		0.386
(0.97) 		0.99
(1.00) 		1
(1.00) 		0.0678
(0.705) 		0.333
(0.959) 		0.679
(1.00) 		0.336
(0.961) 		0.0153
(0.583) 		0.239
(0.895) 		1
(1.00) 		0.183
(0.83) 		0.811
(1.00) 		0.682
(1.00) 		0.0623
(0.675) 		0.51
(0.997) 		0.829
(1.00) 		0.498
(0.997) 		0.694
(1.00) 		0.724
(1.00) 		1
(1.00) 		0.00468
(0.456) 		0.0891
(0.739)
9q loss 51 (17%) 244 0.281
(0.927) 		0.00356
(0.437) 		0.114
(0.771) 		0.639
(1.00) 		0.407
(0.979) 		0.834
(1.00) 		0.507
(0.997) 		0.642
(1.00) 		0.813
(1.00) 		0.521
(0.997) 		1
(1.00) 		0.758
(1.00) 		0.0448
(0.617) 		0.816
(1.00) 		0.382
(0.97) 		0.642
(1.00) 		0.342
(0.967) 		0.863
(1.00) 		1
(1.00) 		0.0423
(0.607) 		0.314
(0.943) 		0.655
(1.00) 		0.198
(0.845) 		0.0331
(0.607) 		0.293
(0.93) 		1
(1.00) 		0.122
(0.771) 		0.818
(1.00) 		0.813
(1.00) 		0.382
(0.97) 		0.343
(0.967) 		0.312
(0.943) 		0.494
(0.997) 		0.314
(0.943) 		0.734
(1.00) 		1
(1.00) 		0.00418
(0.456) 		0.472
(0.994)
10p loss 66 (22%) 229 0.26
(0.906) 		0.0791
(0.719) 		0.0888
(0.739) 		0.0462
(0.619) 		0.686
(1.00) 		0.425
(0.993) 		0.762
(1.00) 		0.944
(1.00) 		0.0183
(0.586) 		0.157
(0.806) 		0.788
(1.00) 		0.536
(0.997) 		0.242
(0.895) 		0.0184
(0.586) 		0.606
(1.00) 		0.944
(1.00) 		0.0118
(0.528) 		0.46
(0.994) 		1
(1.00) 		0.188
(0.832) 		0.54
(0.997) 		0.343
(0.967) 		0.0926
(0.743) 		0.368
(0.97) 		0.287
(0.93) 		0.0364
(0.607) 		0.354
(0.97) 		0.0381
(0.607) 		0.0183
(0.586) 		0.317
(0.943) 		0.0681
(0.705) 		0.123
(0.771) 		0.874
(1.00) 		0.0989
(0.749) 		0.738
(1.00) 		0.245
(0.895) 		0.262
(0.906) 		0.0909
(0.743) 		0.069
(0.709)
12p loss 40 (14%) 255 0.399
(0.97) 		0.9
(1.00) 		0.58
(1.00) 		1
(1.00) 		0.358
(0.97) 		0.465
(0.994) 		0.936
(1.00) 		0.263
(0.906) 		0.887
(1.00) 		0.642
(1.00) 		0.317
(0.943) 		0.484
(0.997) 		0.693
(1.00) 		0.108
(0.769) 		0.692
(1.00) 		0.263
(0.906) 		0.152
(0.806) 		0.394
(0.97) 		1
(1.00) 		0.122
(0.771) 		0.277
(0.927) 		0.539
(0.997) 		0.111
(0.771) 		0.971
(1.00) 		0.472
(0.994) 		0.676
(1.00) 		0.48
(0.997) 		1
(1.00) 		0.887
(1.00) 		0.29
(0.93) 		0.605
(1.00) 		0.379
(0.97) 		0.431
(0.994) 		0.0401
(0.607) 		0.125
(0.771) 		0.665
(1.00) 		0.863
(1.00) 		0.184
(0.83)
12q loss 15 (5%) 280 0.48
(0.997) 		0.0521
(0.641) 		0.0224
(0.607) 		0.369
(0.97) 		1
(1.00) 		0.101
(0.753) 		0.331
(0.959) 		0.138
(0.798) 		0.205
(0.855) 		0.506
(0.997) 		0.615
(1.00) 		0.147
(0.806) 		0.335
(0.961) 		0.507
(0.997) 		0.138
(0.798) 		0.814
(1.00) 		0.666
(1.00) 		1
(1.00) 		0.12
(0.771) 		0.55
(0.997) 		0.665
(1.00) 		0.181
(0.83) 		0.608
(1.00) 		0.387
(0.97) 		0.828
(1.00) 		0.0815
(0.722) 		1
(1.00) 		0.205
(0.855) 		0.946
(1.00) 		0.362
(0.97) 		0.164
(0.818) 		0.784
(1.00) 		0.0756
(0.719) 		1
(1.00) 		0.385
(0.97) 		0.055
(0.649) 		0.0332
(0.607)
13q loss 80 (27%) 215 0.933
(1.00) 		0.186
(0.831) 		0.105
(0.765) 		0.0278
(0.607) 		0.463
(0.994) 		0.279
(0.927) 		0.00515
(0.456) 		0.415
(0.987) 		0.00815
(0.511) 		0.685
(1.00) 		0.202
(0.854) 		0.675
(1.00) 		0.877
(1.00) 		0.114
(0.771) 		0.119
(0.771) 		0.415
(0.987) 		0.0403
(0.607) 		0.0324
(0.607) 		0.53
(0.997) 		0.117
(0.771) 		0.803
(1.00) 		0.991
(1.00) 		0.0417
(0.607) 		0.621
(1.00) 		0.373
(0.97) 		0.837
(1.00) 		0.843
(1.00) 		0.0229
(0.607) 		0.00815
(0.511) 		0.611
(1.00) 		1
(1.00) 		0.0339
(0.607) 		0.887
(1.00) 		0.684
(1.00) 		0.0484
(0.628) 		0.291
(0.93) 		0.134
(0.795) 		0.0435
(0.61)
14q loss 35 (12%) 260 0.742
(1.00) 		0.0106
(0.525) 		0.574
(1.00) 		0.81
(1.00) 		0.354
(0.97) 		0.0977
(0.745) 		0.389
(0.97) 		0.0359
(0.607) 		0.661
(1.00) 		0.509
(0.997) 		1
(1.00) 		0.423
(0.993) 		0.816
(1.00) 		0.0413
(0.607) 		0.95
(1.00) 		0.0359
(0.607) 		0.656
(1.00) 		0.89
(1.00) 		1
(1.00) 		0.404
(0.976) 		0.483
(0.997) 		0.627
(1.00) 		0.776
(1.00) 		0.0931
(0.743) 		0.898
(1.00) 		1
(1.00) 		0.043
(0.607) 		1
(1.00) 		0.661
(1.00) 		0.628
(1.00) 		0.436
(0.994) 		0.903
(1.00) 		0.142
(0.806) 		0.116
(0.771) 		1
(1.00) 		0.236
(0.895) 		0.012
(0.528) 		0.879
(1.00)
15q loss 47 (16%) 248 0.423
(0.993) 		0.00483
(0.456) 		0.0677
(0.705) 		0.493
(0.997) 		0.115
(0.771) 		0.391
(0.97) 		0.184
(0.83) 		0.376
(0.97) 		0.801
(1.00) 		0.0212
(0.607) 		0.747
(1.00) 		0.821
(1.00) 		0.707
(1.00) 		0.00872
(0.518) 		0.0723
(0.719) 		0.376
(0.97) 		0.797
(1.00) 		0.402
(0.975) 		1
(1.00) 		0.907
(1.00) 		0.69
(1.00) 		0.0753
(0.719) 		0.58
(1.00) 		0.535
(0.997) 		0.517
(0.997) 		1
(1.00) 		0.0918
(0.743) 		0.789
(1.00) 		0.801
(1.00) 		0.989
(1.00) 		1
(1.00) 		0.725
(1.00) 		0.755
(1.00) 		0.898
(1.00) 		1
(1.00) 		0.232
(0.895) 		1
(1.00) 		0.00557
(0.456) 		0.0954
(0.745)
16p loss 34 (12%) 261 0.206
(0.855) 		0.0826
(0.729) 		0.0428
(0.607) 		0.04
(0.607) 		0.179
(0.83) 		0.602
(1.00) 		0.148
(0.806) 		0.777
(1.00) 		0.316
(0.943) 		0.943
(1.00) 		0.476
(0.996) 		0.632
(1.00) 		0.385
(0.97) 		0.112
(0.771) 		0.707
(1.00) 		0.777
(1.00) 		0.293
(0.93) 		0.983
(1.00) 		1
(1.00) 		0.488
(0.997) 		0.553
(0.997) 		0.987
(1.00) 		0.941
(1.00) 		0.501
(0.997) 		0.923
(1.00) 		0.505
(0.997) 		0.488
(0.997) 		0.588
(1.00) 		0.316
(0.943) 		0.663
(1.00) 		0.0455
(0.617) 		0.0973
(0.745) 		0.926
(1.00) 		0.817
(1.00) 		1
(1.00) 		0.507
(0.997) 		0.0431
(0.607) 		0.69
(1.00)
17p loss 95 (32%) 200 0.279
(0.927) 		0.0832
(0.729) 		0.907
(1.00) 		1
(1.00) 		0.722
(1.00) 		0.867
(1.00) 		0.317
(0.943) 		0.569
(1.00) 		0.596
(1.00) 		0.26
(0.906) 		0.242
(0.895) 		0.224
(0.881) 		0.0275
(0.607) 		0.0397
(0.607) 		0.734
(1.00) 		0.569
(1.00) 		0.375
(0.97) 		0.327
(0.953) 		1
(1.00) 		0.528
(0.997) 		0.488
(0.997) 		0.383
(0.97) 		0.459
(0.994) 		0.184
(0.83) 		0.681
(1.00) 		0.653
(1.00) 		0.841
(1.00) 		1
(1.00) 		0.596
(1.00) 		0.47
(0.994) 		0.296
(0.931) 		0.245
(0.895) 		0.29
(0.93) 		0.634
(1.00) 		0.577
(1.00) 		0.837
(1.00) 		0.429
(0.994) 		0.0983
(0.746) 		0.768
(1.00)
17q loss 37 (13%) 258 0.466
(0.994) 		0.00831
(0.511) 		0.641
(1.00) 		0.802
(1.00) 		0.595
(1.00) 		1
(1.00) 		0.219
(0.87) 		0.573
(1.00) 		0.65
(1.00) 		0.193
(0.837) 		0.319
(0.946) 		0.878
(1.00) 		0.39
(0.97) 		0.675
(1.00) 		0.134
(0.795) 		0.573
(1.00) 		0.0735
(0.719) 		0.672
(1.00) 		1
(1.00) 		0.891
(1.00) 		0.333
(0.959) 		0.316
(0.943) 		0.996
(1.00) 		0.414
(0.987) 		0.573
(1.00) 		0.3
(0.936) 		0.343
(0.967) 		0.603
(1.00) 		0.65
(1.00) 		0.906
(1.00) 		0.345
(0.967) 		0.0329
(0.607) 		0.876
(1.00) 		0.0859
(0.734) 		0.363
(0.97) 		0.219
(0.87) 		1
(1.00) 		0.00951
(0.525) 		0.449
(0.994)
18p loss 55 (19%) 240 0.862
(1.00) 		0.45
(0.994) 		0.924
(1.00) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		0.00488
(0.456) 		0.143
(0.806) 		0.445
(0.994) 		0.946
(1.00) 		1
(1.00) 		0.621
(1.00) 		0.86
(1.00) 		0.387
(0.97) 		0.489
(0.997) 		0.143
(0.806) 		0.382
(0.97) 		0.946
(1.00) 		0.536
(0.997) 		0.715
(1.00) 		0.216
(0.869) 		0.541
(0.997) 		0.573
(1.00) 		0.279
(0.927) 		0.816
(1.00) 		0.724
(1.00) 		0.841
(1.00) 		0.0741
(0.719) 		0.445
(0.994) 		0.537
(0.997) 		0.809
(1.00) 		0.139
(0.798) 		0.0407
(0.607) 		0.0607
(0.671) 		0.0694
(0.71) 		0.0249
(0.607) 		0.42
(0.993) 		0.45
(0.994)
19q loss 29 (10%) 266 0.134
(0.795) 		0.239
(0.895) 		0.456
(0.994) 		0.234
(0.895) 		0.563
(1.00) 		0.602
(1.00) 		0.205
(0.855) 		0.25
(0.9) 		0.58
(1.00) 		0.395
(0.97) 		1
(1.00) 		0.743
(1.00) 		0.244
(0.895) 		0.31
(0.943) 		0.503
(0.997) 		0.25
(0.9) 		0.893
(1.00) 		0.184
(0.83) 		1
(1.00) 		0.473
(0.994) 		0.377
(0.97) 		0.962
(1.00) 		0.689
(1.00) 		0.415
(0.988) 		0.763
(1.00) 		0.888
(1.00) 		0.0376
(0.607) 		0.269
(0.915) 		0.58
(1.00) 		0.674
(1.00) 		0.724
(1.00) 		0.206
(0.855) 		0.913
(1.00) 		0.215
(0.869) 		0.686
(1.00) 		0.263
(0.906) 		0.659
(1.00) 		0.255
(0.905) 		0.449
(0.994)
20p loss 23 (8%) 272 0.655
(1.00) 		0.0307
(0.607) 		1
(1.00) 		0.78
(1.00) 		1
(1.00) 		0.192
(0.835) 		0.57
(1.00) 		0.0868
(0.734) 		0.814
(1.00) 		0.383
(0.97) 		0.667
(1.00) 		0.0568
(0.655) 		0.806
(1.00) 		0.851
(1.00) 		0.459
(0.994) 		0.0868
(0.734) 		0.0457
(0.617) 		0.64
(1.00) 		0.107
(0.768) 		0.701
(1.00) 		0.354
(0.97) 		0.0752
(0.719) 		0.945
(1.00) 		0.839
(1.00) 		0.898
(1.00) 		1
(1.00) 		0.85
(1.00) 		0.762
(1.00) 		0.814
(1.00) 		0.863
(1.00) 		0.733
(1.00) 		0.879
(1.00) 		0.157
(0.806) 		0.756
(1.00) 		1
(1.00) 		1
(1.00) 		0.0578
(0.658) 		0.958
(1.00)
21q loss 49 (17%) 246 0.137
(0.798) 		0.482
(0.997) 		0.11
(0.771) 		1
(1.00) 		1
(1.00) 		0.491
(0.997) 		0.686
(1.00) 		0.537
(0.997) 		0.576
(1.00) 		0.117
(0.771) 		0.133
(0.795) 		0.0642
(0.685) 		0.582
(1.00) 		0.0105
(0.525) 		0.537
(0.997) 		0.0484
(0.628) 		0.00784
(0.511) 		0.382
(0.97) 		0.0184
(0.586) 		0.377
(0.97) 		0.717
(1.00) 		0.0348
(0.607) 		0.0332
(0.607) 		0.517
(0.997) 		0.558
(1.00) 		0.892
(1.00) 		0.822
(1.00) 		0.576
(1.00) 		0.193
(0.837) 		0.818
(1.00) 		0.201
(0.851) 		0.1
(0.753) 		0.303
(0.937) 		0.51
(0.997) 		0.711
(1.00) 		0.518
(0.997) 		0.218
(0.87)
22q loss 71 (24%) 224 0.185
(0.83) 		0.447
(0.994) 		0.436
(0.994) 		0.854
(1.00) 		0.721
(1.00) 		0.181
(0.83) 		0.977
(1.00) 		0.78
(1.00) 		0.554
(0.998) 		0.763
(1.00) 		0.79
(1.00) 		0.614
(1.00) 		1
(1.00) 		0.8
(1.00) 		0.00433
(0.456) 		0.78
(1.00) 		0.195
(0.84) 		0.358
(0.97) 		0.53
(0.997) 		0.139
(0.798) 		0.19
(0.832) 		0.177
(0.826) 		0.399
(0.97) 		0.239
(0.895) 		0.864
(1.00) 		0.734
(1.00) 		0.078
(0.719) 		0.459
(0.994) 		0.554
(0.998) 		0.336
(0.961) 		0.322
(0.951) 		0.111
(0.771) 		0.631
(1.00) 		0.245
(0.895) 		0.391
(0.97) 		0.245
(0.895) 		0.659
(1.00) 		0.49
(0.997) 		0.35
(0.97)
xp loss 63 (21%) 232 0.876
(1.00) 		0.261
(0.906) 		0.466
(0.994) 		0.701
(1.00) 		0.362
(0.97) 		0.834
(1.00) 		0.0931
(0.743) 		0.58
(1.00) 		0.828
(1.00) 		0.0889
(0.739) 		0.418
(0.992) 		0.595
(1.00) 		0.61
(1.00) 		0.561
(1.00) 		0.611
(1.00) 		0.58
(1.00) 		0.42
(0.993) 		0.936
(1.00) 		0.188
(0.832) 		0.0476
(0.625) 		0.216
(0.869) 		0.174
(0.821) 		0.012
(0.528) 		0.513
(0.997) 		0.756
(1.00) 		0.13
(0.79) 		0.35
(0.97) 		1
(1.00) 		0.828
(1.00) 		0.5
(0.997) 		0.0294
(0.607) 		0.0334
(0.607) 		0.293
(0.93) 		0.131
(0.791) 		0.519
(0.997) 		1
(1.00) 		0.462
(0.994) 		0.237
(0.895) 		0.6
(1.00)
xq loss 59 (20%) 236 0.0767
(0.719) 		0.332
(0.959) 		0.634
(1.00) 		0.696
(1.00) 		0.649
(1.00) 		0.309
(0.943) 		0.335
(0.961) 		0.777
(1.00) 		0.628
(1.00) 		0.19
(0.833) 		0.6
(1.00) 		0.581
(1.00) 		0.174
(0.821) 		0.742
(1.00) 		0.661
(1.00) 		0.777
(1.00) 		0.984
(1.00) 		0.74
(1.00) 		0.188
(0.832) 		0.218
(0.87) 		0.583
(1.00) 		0.201
(0.851) 		0.0366
(0.607) 		0.612
(1.00) 		0.5
(0.997) 		0.0469
(0.625) 		0.393
(0.97) 		0.832
(1.00) 		0.628
(1.00) 		0.947
(1.00) 		0.0113
(0.525) 		0.441
(0.994) 		0.811
(1.00) 		0.595
(1.00) 		0.516
(0.997) 		0.108
(0.769) 		0.635
(1.00) 		0.305
(0.937) 		0.447
(0.994)
'8q gain' versus 'PATHOLOGY_T_STAGE'

P value = 0.00156 (Fisher's exact test), Q value = 0.23

Table S1.  Gene #16: '8q gain' versus Clinical Feature #3: 'PATHOLOGY_T_STAGE'

nPatients T1 T2 T3 T4
ALL 135 70 21 8
8Q GAIN MUTATED 38 17 12 6
8Q GAIN WILD-TYPE 97 53 9 2

Figure S1.  Get High-res Image Gene #16: '8q gain' versus Clinical Feature #3: 'PATHOLOGY_T_STAGE'

'9q gain' versus 'PREGNANCIES_COUNT_LIVE_BIRTH'

P value = 0.000954 (Wilcoxon-test), Q value = 0.18

Table S2.  Gene #18: '9q gain' versus Clinical Feature #23: 'PREGNANCIES_COUNT_LIVE_BIRTH'

nPatients Mean (Std.Dev)
ALL 251 2.8 (2.0)
9Q GAIN MUTATED 38 3.6 (1.9)
9Q GAIN WILD-TYPE 213 2.7 (2.0)

Figure S2.  Get High-res Image Gene #18: '9q gain' versus Clinical Feature #23: 'PREGNANCIES_COUNT_LIVE_BIRTH'

'xp gain' versus 'PREGNANCIES_COUNT_LIVE_BIRTH'

P value = 0.000884 (Wilcoxon-test), Q value = 0.18

Table S3.  Gene #40: 'xp gain' versus Clinical Feature #23: 'PREGNANCIES_COUNT_LIVE_BIRTH'

nPatients Mean (Std.Dev)
ALL 251 2.8 (2.0)
XP GAIN MUTATED 39 3.9 (2.5)
XP GAIN WILD-TYPE 212 2.6 (1.9)

Figure S3.  Get High-res Image Gene #40: 'xp gain' versus Clinical Feature #23: 'PREGNANCIES_COUNT_LIVE_BIRTH'

'3p loss' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000785 (Wilcoxon-test), Q value = 0.18

Table S4.  Gene #46: '3p loss' versus Clinical Feature #9: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 150 0.9 (2.1)
3P LOSS MUTATED 41 1.3 (1.8)
3P LOSS WILD-TYPE 109 0.8 (2.1)

Figure S4.  Get High-res Image Gene #46: '3p loss' versus Clinical Feature #9: 'NUMBER_OF_LYMPH_NODES'

'3p loss' versus 'LYMPHOVASCULAR_INVOLVEMENT'

P value = 0.00159 (Fisher's exact test), Q value = 0.23

Table S5.  Gene #46: '3p loss' versus Clinical Feature #28: 'LYMPHOVASCULAR_INVOLVEMENT'

nPatients ABSENT PRESENT
ALL 71 74
3P LOSS MUTATED 11 29
3P LOSS WILD-TYPE 60 45

Figure S5.  Get High-res Image Gene #46: '3p loss' versus Clinical Feature #28: 'LYMPHOVASCULAR_INVOLVEMENT'

'3p loss' versus 'LYMPH_NODES_EXAMINED_HE_COUNT'

P value = 0.000785 (Wilcoxon-test), Q value = 0.18

Table S6.  Gene #46: '3p loss' versus Clinical Feature #29: 'LYMPH_NODES_EXAMINED_HE_COUNT'

nPatients Mean (Std.Dev)
ALL 150 0.9 (2.1)
3P LOSS MUTATED 41 1.3 (1.8)
3P LOSS WILD-TYPE 109 0.8 (2.1)

Figure S6.  Get High-res Image Gene #46: '3p loss' versus Clinical Feature #29: 'LYMPH_NODES_EXAMINED_HE_COUNT'

'4p loss' versus 'HISTOLOGICAL_TYPE'

P value = 0.00134 (Fisher's exact test), Q value = 0.21

Table S7.  Gene #48: '4p loss' versus Clinical Feature #7: 'HISTOLOGICAL_TYPE'

nPatients ADENOSQUAMOUS CERVICAL SQUAMOUS CELL CARCINOMA ENDOCERVICAL ADENOCARCINOMA OF THE USUAL TYPE ENDOCERVICAL TYPE OF ADENOCARCINOMA ENDOMETRIOID ADENOCARCINOMA OF ENDOCERVIX MUCINOUS ADENOCARCINOMA OF ENDOCERVICAL TYPE
ALL 6 242 6 21 3 17
4P LOSS MUTATED 2 119 3 2 0 5
4P LOSS WILD-TYPE 4 123 3 19 3 12

Figure S7.  Get High-res Image Gene #48: '4p loss' versus Clinical Feature #7: 'HISTOLOGICAL_TYPE'

'4p loss' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0011 (Wilcoxon-test), Q value = 0.18

Table S8.  Gene #48: '4p loss' versus Clinical Feature #9: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 150 0.9 (2.1)
4P LOSS MUTATED 59 1.4 (2.4)
4P LOSS WILD-TYPE 91 0.6 (1.7)

Figure S8.  Get High-res Image Gene #48: '4p loss' versus Clinical Feature #9: 'NUMBER_OF_LYMPH_NODES'

'4p loss' versus 'LYMPH_NODES_EXAMINED_HE_COUNT'

P value = 0.0011 (Wilcoxon-test), Q value = 0.18

Table S9.  Gene #48: '4p loss' versus Clinical Feature #29: 'LYMPH_NODES_EXAMINED_HE_COUNT'

nPatients Mean (Std.Dev)
ALL 150 0.9 (2.1)
4P LOSS MUTATED 59 1.4 (2.4)
4P LOSS WILD-TYPE 91 0.6 (1.7)

Figure S9.  Get High-res Image Gene #48: '4p loss' versus Clinical Feature #29: 'LYMPH_NODES_EXAMINED_HE_COUNT'

'4q loss' versus 'RADIATION_THERAPY'

P value = 0.000855 (Fisher's exact test), Q value = 0.18

Table S10.  Gene #49: '4q loss' versus Clinical Feature #6: 'RADIATION_THERAPY'

nPatients NO YES
ALL 55 123
4Q LOSS MUTATED 8 49
4Q LOSS WILD-TYPE 47 74

Figure S10.  Get High-res Image Gene #49: '4q loss' versus Clinical Feature #6: 'RADIATION_THERAPY'

'4q loss' versus 'NEOPLASM_HISTOLOGIC_GRADE'

P value = 6e-04 (Fisher's exact test), Q value = 0.18

Table S11.  Gene #49: '4q loss' versus Clinical Feature #14: 'NEOPLASM_HISTOLOGIC_GRADE'

nPatients G1 G2 G3 G4 GX
ALL 18 129 115 1 24
4Q LOSS MUTATED 1 32 51 0 8
4Q LOSS WILD-TYPE 17 97 64 1 16

Figure S11.  Get High-res Image Gene #49: '4q loss' versus Clinical Feature #14: 'NEOPLASM_HISTOLOGIC_GRADE'

'8p loss' versus 'TOBACCO_SMOKING_YEAR_STOPPED'

P value = 0.000626 (Wilcoxon-test), Q value = 0.18

Table S12.  Gene #56: '8p loss' versus Clinical Feature #15: 'TOBACCO_SMOKING_YEAR_STOPPED'

nPatients Mean (Std.Dev)
ALL 43 1999.7 (13.6)
8P LOSS MUTATED 12 2009.2 (4.3)
8P LOSS WILD-TYPE 31 1996.0 (14.3)

Figure S12.  Get High-res Image Gene #56: '8p loss' versus Clinical Feature #15: 'TOBACCO_SMOKING_YEAR_STOPPED'

'10q loss' versus 'NEOPLASM_HISTOLOGIC_GRADE'

P value = 0.00043 (Fisher's exact test), Q value = 0.18

Table S13.  Gene #61: '10q loss' versus Clinical Feature #14: 'NEOPLASM_HISTOLOGIC_GRADE'

nPatients G1 G2 G3 G4 GX
ALL 18 129 115 1 24
10Q LOSS MUTATED 3 20 43 1 7
10Q LOSS WILD-TYPE 15 109 72 0 17

Figure S13.  Get High-res Image Gene #61: '10q loss' versus Clinical Feature #14: 'NEOPLASM_HISTOLOGIC_GRADE'

'11p loss' versus 'YEARS_TO_BIRTH'

P value = 0.000512 (Wilcoxon-test), Q value = 0.18

Table S14.  Gene #62: '11p loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 293 48.1 (13.8)
11P LOSS MUTATED 99 52.3 (14.0)
11P LOSS WILD-TYPE 194 46.0 (13.2)

Figure S14.  Get High-res Image Gene #62: '11p loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'11p loss' versus 'AGE_AT_DIAGNOSIS'

P value = 0.000436 (Wilcoxon-test), Q value = 0.18

Table S15.  Gene #62: '11p loss' versus Clinical Feature #38: 'AGE_AT_DIAGNOSIS'

nPatients Mean (Std.Dev)
ALL 295 48.2 (13.8)
11P LOSS MUTATED 100 52.4 (14.0)
11P LOSS WILD-TYPE 195 46.1 (13.2)

Figure S15.  Get High-res Image Gene #62: '11p loss' versus Clinical Feature #38: 'AGE_AT_DIAGNOSIS'

'11q loss' versus 'YEARS_TO_BIRTH'

P value = 8.58e-05 (Wilcoxon-test), Q value = 0.14

Table S16.  Gene #63: '11q loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 293 48.1 (13.8)
11Q LOSS MUTATED 115 52.2 (13.8)
11Q LOSS WILD-TYPE 178 45.5 (13.1)

Figure S16.  Get High-res Image Gene #63: '11q loss' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'11q loss' versus 'MENOPAUSE_STATUS'

P value = 0.00107 (Fisher's exact test), Q value = 0.18

Table S17.  Gene #63: '11q loss' versus Clinical Feature #27: 'MENOPAUSE_STATUS'

nPatients INDETERMINATE (NEITHER PRE OR POSTMENOPAUSAL) PERI (6-12 MONTHS SINCE LAST MENSTRUAL PERIOD) POST (PRIOR BILATERAL OVARIECTOMY OR >12 MO SINCE LMP WITH NO PRIOR HYSTERECTOMY) PRE (<6 MONTHS SINCE LMP AND NO PRIOR BILATERAL OVARIECTOMY AND NOT ON ESTROGEN REPLACEMENT)
ALL 2 25 82 121
11Q LOSS MUTATED 1 13 44 35
11Q LOSS WILD-TYPE 1 12 38 86

Figure S17.  Get High-res Image Gene #63: '11q loss' versus Clinical Feature #27: 'MENOPAUSE_STATUS'

'11q loss' versus 'AGE_AT_DIAGNOSIS'

P value = 0.000136 (Wilcoxon-test), Q value = 0.14

Table S18.  Gene #63: '11q loss' versus Clinical Feature #38: 'AGE_AT_DIAGNOSIS'

nPatients Mean (Std.Dev)
ALL 295 48.2 (13.8)
11Q LOSS MUTATED 115 52.2 (13.8)
11Q LOSS WILD-TYPE 180 45.6 (13.2)

Figure S18.  Get High-res Image Gene #63: '11q loss' versus Clinical Feature #38: 'AGE_AT_DIAGNOSIS'

'16q loss' versus 'HISTOLOGICAL_TYPE'

P value = 8e-05 (Fisher's exact test), Q value = 0.14

Table S19.  Gene #70: '16q loss' versus Clinical Feature #7: 'HISTOLOGICAL_TYPE'

nPatients ADENOSQUAMOUS CERVICAL SQUAMOUS CELL CARCINOMA ENDOCERVICAL ADENOCARCINOMA OF THE USUAL TYPE ENDOCERVICAL TYPE OF ADENOCARCINOMA ENDOMETRIOID ADENOCARCINOMA OF ENDOCERVIX MUCINOUS ADENOCARCINOMA OF ENDOCERVICAL TYPE
ALL 6 242 6 21 3 17
16Q LOSS MUTATED 0 26 4 8 1 5
16Q LOSS WILD-TYPE 6 216 2 13 2 12

Figure S19.  Get High-res Image Gene #70: '16q loss' versus Clinical Feature #7: 'HISTOLOGICAL_TYPE'

'18q loss' versus 'HISTOLOGICAL_TYPE'

P value = 0.00028 (Fisher's exact test), Q value = 0.18

Table S20.  Gene #74: '18q loss' versus Clinical Feature #7: 'HISTOLOGICAL_TYPE'

nPatients ADENOSQUAMOUS CERVICAL SQUAMOUS CELL CARCINOMA ENDOCERVICAL ADENOCARCINOMA OF THE USUAL TYPE ENDOCERVICAL TYPE OF ADENOCARCINOMA ENDOMETRIOID ADENOCARCINOMA OF ENDOCERVIX MUCINOUS ADENOCARCINOMA OF ENDOCERVICAL TYPE
ALL 6 242 6 21 3 17
18Q LOSS MUTATED 0 50 1 12 2 8
18Q LOSS WILD-TYPE 6 192 5 9 1 9

Figure S20.  Get High-res Image Gene #74: '18q loss' versus Clinical Feature #7: 'HISTOLOGICAL_TYPE'

'19p loss' versus 'Time to Death'

P value = 0.000386 (logrank test), Q value = 0.18

Table S21.  Gene #75: '19p loss' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 278 67 0.0 - 210.7 (23.2)
19P LOSS MUTATED 57 23 0.1 - 147.3 (21.1)
19P LOSS WILD-TYPE 221 44 0.0 - 210.7 (24.0)

Figure S21.  Get High-res Image Gene #75: '19p loss' versus Clinical Feature #1: 'Time to Death'

'20q loss' versus 'Time to Death'

P value = 0.000745 (logrank test), Q value = 0.18

Table S22.  Gene #78: '20q loss' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 278 67 0.0 - 210.7 (23.2)
20Q LOSS MUTATED 10 6 4.7 - 50.5 (18.8)
20Q LOSS WILD-TYPE 268 61 0.0 - 210.7 (23.8)

Figure S22.  Get High-res Image Gene #78: '20q loss' versus Clinical Feature #1: 'Time to Death'

Methods & Data
Input

  • Copy number data file = broad_values_by_arm.txt from GISTIC pipeline

  • Processed Copy number data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/CESC-TP/19779738/transformed.cor.cli.txt

  • Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/CESC-TP/19775059/CESC-TP.merged_data.txt

  • Number of patients = 295

  • Number of significantly arm-level cnvs = 82

  • Number of selected clinical features = 39

  • Exclude regions that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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