Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q PTEN 15 (8%) 179 0.56821 0.745 0.34232 0.611 0.62019 0.775 0.58992 0.761 0.02631 0.197 0.22826 0.537 0.43211 0.681 0.19301 0.508 1 1 0.42103 0.681 HLA-B 11 (6%) 183 0.51884 0.729 0.16381 0.479 0.42806 0.681 0.32574 0.611 0.23836 0.544 0.092409 0.348 0.01882 0.186 0.1346 0.426 0.01245 0.146 0.04818 0.268 HLA-A 16 (8%) 178 0.25927 0.558 0.093829 0.348 0.34365 0.611 0.01712 0.186 0.00085999 0.046 0.067589 0.314 0.43009 0.681 0.0076999 0.11 0.69247 0.815 0.41779 0.681 KRAS 11 (6%) 183 0.56622 0.745 0.00408 0.0792 0.40012 0.668 0.21924 0.537 0.00451 0.0792 0.00158 0.0632 0.00319 0.0792 0.00091999 0.046 0.0363 0.234 0.00016 0.032 MLL2 22 (11%) 172 0.67201 0.808 0.24188 0.544 0.89423 0.983 0.24049 0.544 0.52106 0.729 0.079689 0.335 0.88199 0.975 0.3126 0.611 0.090409 0.348 0.73593 0.856 FBXW7 19 (10%) 175 0.49627 0.709 0.25833 0.558 0.32895 0.611 0.97186 1 0.3421 0.611 0.67845 0.808 0.40058 0.668 0.45529 0.685 0.22417 0.537 0.53944 0.739 EP300 21 (11%) 173 1 1 0.02656 0.197 0.7644 0.874 0.03866 0.242 0.13618 0.426 0.072889 0.317 0.83884 0.937 0.0095599 0.121 1 1 0.24741 0.55 MAPK1 9 (5%) 185 0.55046 0.739 0.22766 0.537 0.2751 0.585 0.97554 1 0.092509 0.348 0.053409 0.268 0.18508 0.495 0.083249 0.34 0.02179 0.186 0.0223 0.186 MLL3 29 (15%) 165 0.96439 1 0.0453 0.268 0.0096899 0.121 0.02084 0.186 0.051079 0.268 0.02224 0.186 0.02442 0.195 0.83628 0.937 0.62911 0.777 0.61445 0.773 ARID1A 14 (7%) 180 0.0062899 0.0968 0.00427 0.0792 0.65412 0.798 0.12547 0.413 0.16738 0.479 0.00062999 0.046 0.10091 0.354 0.00431 0.0792 0.70217 0.821 0.00475 0.0792 NFE2L2 12 (6%) 182 0.92583 0.996 0.099009 0.354 0.46253 0.685 0.04941 0.268 0.45534 0.685 0.04649 0.268 0.0357 0.234 0.01841 0.186 0.38363 0.656 0.072569 0.317 PIK3CA 53 (27%) 141 0.03449 0.234 0.28194 0.594 0.30414 0.611 0.29795 0.61 0.35148 0.615 0.004 0.0792 0.33149 0.611 0.34544 0.611 0.48121 0.692 0.2316 0.539 CASP8 9 (5%) 185 0.677 0.808 0.47592 0.692 0.18568 0.495 0.16768 0.479 0.22129 0.537 0.45899 0.685 0.56981 0.745 0.45126 0.685 0.12483 0.413 0.43255 0.681 FAT2 11 (6%) 183 0.61466 0.773 0.051889 0.268 0.53864 0.739 0.6265 0.777 0.063989 0.305 0.48034 0.692 0.58552 0.76 0.76218 0.874 0.069379 0.315 0.091499 0.348 ZNF750 9 (5%) 185 0.13219 0.426 0.56128 0.745 0.41997 0.681 0.32091 0.611 0.603 0.773 0.30701 0.611 0.31959 0.611 0.096029 0.349 0.54913 0.739 0.080419 0.335 C12ORF43 4 (2%) 190 0.19914 0.509 0.14464 0.438 NA NA NA NA 0.91202 0.986 0.45186 0.685 0.47322 0.692 0.20568 0.514 0.29231 0.609 0.16242 0.479 C3ORF70 4 (2%) 190 0.54981 0.739 0.34237 0.611 0.37746 0.651 0.17823 0.495 0.65276 0.798 0.12581 0.413 0.18383 0.495 0.2987 0.61 0.32117 0.611 0.12607 0.413 BAP1 4 (2%) 190 0.14008 0.431 0.058969 0.288 NA NA NA NA 0.51019 0.724 0.45361 0.685 0.68894 0.815 0.3536 0.615 0.25853 0.558 0.17232 0.485 USP28 4 (2%) 190 0.19933 0.509 0.54277 0.739 0.66076 0.801 0.91122 0.986 0.60717 0.773 1 1 0.38883 0.659 0.93687 1 0.20098 0.509 0.81836 0.925 IFNGR1 6 (3%) 188 1 1 0.74313 0.859 0.45298 0.685 0.91061 0.986 0.84325 0.937 1 1 0.32681 0.611 0.03295 0.234 0.053529 0.268 0.78638 0.894