E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.081 0.104 0.285 5.0 -0.274 6.0 11.0 KLHL20 0.042 0.052 0.155 16.0 -9999.0 0.0 16.0 CYFIP2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.066 0.08 0.234 24.0 -9999.0 0.0 24.0 ENAH 0.083 0.117 0.289 13.0 -0.279 9.0 22.0 AP1M1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.022 0.037 0.109 1.0 -9999.0 0.0 1.0 ABI1/Sra1/Nap1 -0.006 0.016 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.155 0.088 0.211 208.0 -9999.0 0.0 208.0 RAPGEF1 0.066 0.11 0.263 22.0 -0.258 10.0 32.0 CTNND1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.097 0.12 0.209 5.0 -0.249 20.0 25.0 CRK 0.07 0.112 0.277 19.0 -0.271 10.0 29.0 E-cadherin/gamma catenin/alpha catenin 0.17 0.075 0.208 233.0 -9999.0 0.0 233.0 alphaE/beta7 Integrin 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.036 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.124 0.138 0.293 77.0 -0.281 7.0 84.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.0 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.019 -9999.0 0.0 -0.156 2.0 2.0 PI3K 0.004 0.023 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.185 0.071 0.216 246.0 -9999.0 0.0 246.0 TIAM1 0.018 0.026 -9999.0 0.0 -0.29 2.0 2.0 E-cadherin(dimer)/Ca2+ 0.152 0.078 0.196 218.0 -9999.0 0.0 218.0 AKT1 0.007 0.026 0.099 15.0 -9999.0 0.0 15.0 PIK3R1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.255 0.097 0.294 251.0 -9999.0 0.0 251.0 RhoA/GDP 0.072 0.071 0.234 24.0 -9999.0 0.0 24.0 actin cytoskeleton organization 0.036 0.044 0.127 28.0 -9999.0 0.0 28.0 CDC42/GDP 0.065 0.08 0.234 24.0 -9999.0 0.0 24.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.076 0.036 0.14 2.0 -9999.0 0.0 2.0 ITGB7 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.163 0.083 0.211 218.0 -9999.0 0.0 218.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.141 0.073 0.183 219.0 -9999.0 0.0 219.0 mol:GDP 0.062 0.083 0.242 24.0 -0.207 1.0 25.0 CDC42/GTP/IQGAP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.073 0.079 0.238 23.0 -9999.0 0.0 23.0 RAC1/GTP/IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.03 0.036 0.123 16.0 -9999.0 0.0 16.0 NME1 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.075 0.111 0.274 2.0 -0.249 19.0 21.0 regulation of cell-cell adhesion 0.014 0.029 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.015 0.023 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.042 0.057 0.188 21.0 -9999.0 0.0 21.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.158 0.085 0.209 210.0 -9999.0 0.0 210.0 CCND1 0.033 0.037 0.128 14.0 -9999.0 0.0 14.0 VAV2 0.097 0.116 0.315 10.0 -9999.0 0.0 10.0 RAP1/GDP 0.057 0.066 0.223 21.0 -9999.0 0.0 21.0 adherens junction assembly 0.075 0.109 0.271 2.0 -0.243 19.0 21.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.141 0.082 0.193 201.0 -9999.0 0.0 201.0 E-cadherin/beta catenin 0.106 0.049 0.132 217.0 -9999.0 0.0 217.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.085 0.121 0.29 18.0 -0.249 19.0 37.0 PIK3CA 0.013 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.008 0.03 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin 0.16 0.083 0.208 219.0 -9999.0 0.0 219.0 ITGAE 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.096 0.122 0.197 4.0 -0.254 20.0 24.0