Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.028 0.061 0.3 14.0 -0.236 1.0 15.0 KIRREL 0.022 0.047 -9999.0 0.0 -0.407 5.0 5.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.028 0.061 0.237 1.0 -0.301 14.0 15.0 PLCG1 0.016 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.044 0.075 0.23 1.0 -0.232 28.0 29.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.021 0.032 0.161 1.0 -0.209 4.0 5.0 FYN 0.012 0.061 0.272 11.0 -0.227 6.0 17.0 mol:Ca2+ 0.028 0.056 -9999.0 0.0 -0.315 2.0 2.0 mol:DAG 0.029 0.056 -9999.0 0.0 -0.316 2.0 2.0 NPHS2 0.013 0.045 -9999.0 0.0 -0.422 4.0 4.0 mol:IP3 0.029 0.056 -9999.0 0.0 -0.316 2.0 2.0 regulation of endocytosis 0.036 0.049 0.21 1.0 -0.24 3.0 4.0 Nephrin/NEPH1/podocin/Cholesterol 0.036 0.054 0.211 1.0 -0.226 16.0 17.0 establishment of cell polarity 0.028 0.061 0.236 1.0 -0.3 14.0 15.0 Nephrin/NEPH1/podocin/NCK1-2 0.065 0.058 -9999.0 0.0 -0.38 1.0 1.0 Nephrin/NEPH1/beta Arrestin2 0.038 0.051 0.218 1.0 -0.242 3.0 4.0 NPHS1 0.015 0.067 0.327 1.0 -0.428 9.0 10.0 Nephrin/NEPH1/podocin 0.038 0.049 0.214 1.0 -0.2 16.0 17.0 TJP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.001 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.029 0.057 -9999.0 0.0 -0.317 2.0 2.0 CD2AP 0.016 0.068 -9999.0 0.0 -0.395 12.0 12.0 Nephrin/NEPH1/podocin/GRB2 0.051 0.059 0.23 1.0 -0.229 16.0 17.0 GRB2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.012 0.078 0.281 9.0 -0.235 23.0 32.0 cytoskeleton organization 0.01 0.042 0.196 5.0 -0.239 5.0 10.0 Nephrin/NEPH1 0.025 0.043 0.194 1.0 -0.205 14.0 15.0 Nephrin/NEPH1/ZO-1 0.04 0.053 0.225 1.0 -0.239 12.0 13.0