Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.027 0.043 -9999.0 0.0 -0.343 1.0 1.0 IHH 0.033 0.042 -9999.0 0.0 -0.449 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.026 0.11 -9999.0 0.0 -0.233 30.0 30.0 LRPAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.026 0.11 0.231 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 0.033 0.059 -9999.0 0.0 -0.357 1.0 1.0 SMO 0.019 0.047 -9999.0 0.0 -0.37 1.0 1.0 AKT1 0.0 0.111 -9999.0 0.0 -0.382 3.0 3.0 ARRB2 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.019 0.046 -9999.0 0.0 -0.366 1.0 1.0 STIL -0.002 0.078 -9999.0 0.0 -0.25 1.0 1.0 DHH N/PTCH2 0.041 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.04 0.033 -9999.0 0.0 -0.289 1.0 1.0 PIK3CA 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.025 0.049 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.019 0.046 -9999.0 0.0 -0.366 1.0 1.0 PIK3R1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.025 0.048 -9999.0 0.0 -0.445 1.0 1.0 IHH N/Hhip -0.027 0.143 -9999.0 0.0 -0.306 30.0 30.0 DHH N/Hhip -0.024 0.127 -9999.0 0.0 -0.272 30.0 30.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.019 0.046 -9999.0 0.0 -0.366 1.0 1.0 pancreas development -0.057 0.166 -9999.0 0.0 -0.384 30.0 30.0 HHAT -0.009 0.117 -9999.0 0.0 -0.385 13.0 13.0 PI3K 0.041 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.046 0.151 -9999.0 0.0 -0.311 32.0 32.0 somite specification 0.019 0.046 -9999.0 0.0 -0.366 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.009 0.068 -9999.0 0.0 -0.258 1.0 1.0 SHH Np/Cholesterol/PTCH2 0.003 0.067 -9999.0 0.0 -0.207 13.0 13.0 SHH Np/Cholesterol/Megalin 0.003 0.067 -9999.0 0.0 -0.208 13.0 13.0 SHH -0.033 0.078 0.25 1.0 -0.272 13.0 14.0 catabolic process 0.024 0.035 -9999.0 0.0 -0.323 1.0 1.0 SMO/Vitamin D3 0.009 0.071 -9999.0 0.0 -0.314 1.0 1.0 SHH Np/Cholesterol/Hhip -0.039 0.113 -9999.0 0.0 -0.229 36.0 36.0 LRP2 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis 0.003 0.071 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC 0.005 0.065 -9999.0 0.0 -0.208 12.0 12.0 SHH Np/Cholesterol/CDO 0.003 0.067 -9999.0 0.0 -0.208 13.0 13.0 mesenchymal cell differentiation 0.039 0.112 0.228 36.0 -9999.0 0.0 36.0 mol:Vitamin D3 0.014 0.078 -9999.0 0.0 -0.26 1.0 1.0 IHH N/PTCH2 0.042 0.028 -9999.0 0.0 -0.264 1.0 1.0 CDON 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.037 0.035 -9999.0 0.0 -0.326 1.0 1.0 Megalin/LRPAP1 0.04 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.006 0.063 -9999.0 0.0 -0.205 13.0 13.0 PTCH1 0.024 0.035 -9999.0 0.0 -0.324 1.0 1.0 HHIP -0.057 0.167 -9999.0 0.0 -0.385 30.0 30.0