Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.007 0.083 -9999.0 0.0 -0.213 19.0 19.0 epithelial cell differentiation 0.051 0.044 -9999.0 0.0 -0.197 4.0 4.0 CYFIP2 0.019 0.059 -9999.0 0.0 -0.385 3.0 3.0 ENAH -0.023 0.036 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.017 0.059 -9999.0 0.0 -0.385 3.0 3.0 EPHA2 0.019 0.033 -9999.0 0.0 -0.122 7.0 7.0 MYO6 -0.022 0.029 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.013 -9999.0 0.0 -0.122 1.0 1.0 ABI1/Sra1/Nap1 0.051 0.042 -9999.0 0.0 -0.231 3.0 3.0 AQP5 0.007 0.031 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.021 0.029 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.027 0.043 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.067 0.161 -9999.0 0.0 -0.293 43.0 43.0 NCKAP1 0.027 0.012 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.005 0.04 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization 0.051 0.044 -9999.0 0.0 -0.197 4.0 4.0 GO:0000145 -0.02 0.028 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.057 0.045 -9999.0 0.0 -0.199 4.0 4.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.031 0.031 -9999.0 0.0 -0.22 2.0 2.0 ARF6 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.065 0.029 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.008 0.028 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.021 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.067 0.035 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.017 0.067 -9999.0 0.0 -0.385 4.0 4.0 EGFR/EGFR/EGF/EGF -0.002 0.103 -9999.0 0.0 -0.196 30.0 30.0 RhoA/GDP 0.053 0.043 -9999.0 0.0 -0.19 4.0 4.0 actin cytoskeleton organization -0.022 0.029 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.215 0.203 -9999.0 0.0 -0.385 86.0 86.0 DIAPH1 0.035 0.124 -9999.0 0.0 -0.582 5.0 5.0 Wnt receptor signaling pathway -0.051 0.044 0.197 4.0 -9999.0 0.0 4.0 RHOA 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.032 0.031 -9999.0 0.0 -0.221 2.0 2.0 CTNNA1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.022 0.03 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.023 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.042 0.048 -9999.0 0.0 -0.21 4.0 4.0 SEC6/SEC8 -0.027 0.028 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.027 0.043 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET 0.056 0.049 -9999.0 0.0 -0.203 3.0 3.0 HGF 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.007 0.084 -9999.0 0.0 -0.215 19.0 19.0 actin cable formation -0.009 0.061 0.262 2.0 -9999.0 0.0 2.0 KIAA1543 -0.021 0.028 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 -0.022 0.03 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.021 0.03 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.039 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.051 0.044 -9999.0 0.0 -0.197 4.0 4.0 EXOC4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.021 0.03 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.021 0.03 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.014 0.125 -9999.0 0.0 -0.385 15.0 15.0 ABI1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.021 0.05 0.288 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.007 0.034 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.095 0.121 -9999.0 0.0 -0.194 85.0 85.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.04 0.074 -9999.0 0.0 -0.122 65.0 65.0 PLEKHA7 -0.022 0.029 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.063 0.028 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.014 0.064 0.318 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.007 0.083 -9999.0 0.0 -0.213 19.0 19.0 regulation of cell-cell adhesion -0.022 0.029 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.007 0.084 -9999.0 0.0 -0.215 19.0 19.0