Correlation between copy number variation genes (focal events) and selected clinical features
Colorectal Adenocarcinoma (Primary solid tumor)
21 August 2015  |  analyses__2015_08_21
Maintainer Information
Citation Information
doi:10.7908/C1Z31XVJ
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2015): Correlation between copy number variation genes (focal events) and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C1Z31XVJ
Overview
Introduction

This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.

Summary

Testing the association between copy number variation 73 focal events and 14 clinical features across 612 patients, 355 significant findings detected with Q value < 0.25.

  • amp_1q31.1 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'RADIATION_THERAPY', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_2q33.1 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_5p12 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_5q22.3 cnv correlated to 'PATHOLOGY_M_STAGE' and 'RESIDUAL_TUMOR'.

  • amp_6p21.1 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_7p21.3 cnv correlated to 'YEARS_TO_BIRTH',  'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_8p11.21 cnv correlated to 'RESIDUAL_TUMOR'.

  • amp_8q12.1 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'RESIDUAL_TUMOR'.

  • amp_8q24.21 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_M_STAGE', and 'HISTOLOGICAL_TYPE'.

  • amp_11p15.5 cnv correlated to 'YEARS_TO_BIRTH',  'TUMOR_TISSUE_SITE', and 'HISTOLOGICAL_TYPE'.

  • amp_12p13.32 cnv correlated to 'PATHOLOGY_N_STAGE'.

  • amp_13q12.13 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR',  'NUMBER_OF_LYMPH_NODES', and 'RACE'.

  • amp_13q12.2 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR',  'NUMBER_OF_LYMPH_NODES', and 'RACE'.

  • amp_13q22.1 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_15q26.1 cnv correlated to 'PATHOLOGY_N_STAGE' and 'NUMBER_OF_LYMPH_NODES'.

  • amp_16p11.2 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_17q12 cnv correlated to 'Time to Death',  'PATHOLOGY_M_STAGE', and 'RESIDUAL_TUMOR'.

  • amp_17q24.1 cnv correlated to 'Time to Death',  'PATHOLOGY_M_STAGE', and 'HISTOLOGICAL_TYPE'.

  • amp_19p13.2 cnv correlated to 'HISTOLOGICAL_TYPE'.

  • amp_19q12 cnv correlated to 'PATHOLOGY_M_STAGE' and 'HISTOLOGICAL_TYPE'.

  • amp_20p12.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_M_STAGE',  'GENDER',  'RADIATION_THERAPY', and 'HISTOLOGICAL_TYPE'.

  • amp_20p11.21 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_M_STAGE',  'GENDER', and 'HISTOLOGICAL_TYPE'.

  • amp_20q11.21 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_20q12 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • amp_20q13.31 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • del_1p36.11 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_1p33 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_1p13.2 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_2p12 cnv correlated to 'TUMOR_TISSUE_SITE',  'RADIATION_THERAPY', and 'HISTOLOGICAL_TYPE'.

  • del_2q22.1 cnv correlated to 'RACE'.

  • del_3p26.3 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_T_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_3p14.2 cnv correlated to 'PATHOLOGY_M_STAGE'.

  • del_3q26.31 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_M_STAGE', and 'HISTOLOGICAL_TYPE'.

  • del_4p16.2 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_4q22.1 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'GENDER',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_4q35.1 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_5q12.1 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_5q21.2 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_5q22.2 cnv correlated to 'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_6p25.3 cnv correlated to 'YEARS_TO_BIRTH',  'GENDER',  'RADIATION_THERAPY', and 'RACE'.

  • del_6q26 cnv correlated to 'Time to Death',  'PATHOLOGY_N_STAGE',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE',  'NUMBER_OF_LYMPH_NODES', and 'RACE'.

  • del_7q31.1 cnv correlated to 'RADIATION_THERAPY' and 'ETHNICITY'.

  • del_8p23.2 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_T_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'GENDER',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • del_8p22 cnv correlated to 'Time to Death',  'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_T_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • del_8q11.1 cnv correlated to 'PATHOLOGY_N_STAGE' and 'NUMBER_OF_LYMPH_NODES'.

  • del_9p24.2 cnv correlated to 'PATHOLOGY_M_STAGE',  'GENDER',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_10p15.3 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_10q21.1 cnv correlated to 'YEARS_TO_BIRTH',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE',  'NUMBER_OF_LYMPH_NODES', and 'ETHNICITY'.

  • del_10q23.31 cnv correlated to 'YEARS_TO_BIRTH',  'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_10q25.2 cnv correlated to 'YEARS_TO_BIRTH',  'PATHOLOGY_N_STAGE',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_11q22.3 cnv correlated to 'TUMOR_TISSUE_SITE',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_12p13.1 cnv correlated to 'Time to Death',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE', and 'HISTOLOGICAL_TYPE'.

  • del_12q21.33 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_14q11.2 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGY_N_STAGE', and 'HISTOLOGICAL_TYPE'.

  • del_14q31.1 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_15q11.2 cnv correlated to 'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_15q15.2 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_15q21.1 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_15q22.33 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_T_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_16p13.3 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE', and 'PATHOLOGY_T_STAGE'.

  • del_16q23.1 cnv correlated to 'Time to Death'.

  • del_17p12 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_17q24.3 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_18p11.31 cnv correlated to 'YEARS_TO_BIRTH',  'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • del_18q12.2 cnv correlated to 'YEARS_TO_BIRTH',  'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • del_18q21.2 cnv correlated to 'YEARS_TO_BIRTH',  'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'GENDER',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE',  'RESIDUAL_TUMOR', and 'NUMBER_OF_LYMPH_NODES'.

  • del_18q22.1 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'GENDER',  'RADIATION_THERAPY',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_19p13.3 cnv correlated to 'TUMOR_TISSUE_SITE',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_20p12.1 cnv correlated to 'TUMOR_TISSUE_SITE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

  • del_21q11.2 cnv correlated to 'TUMOR_TISSUE_SITE',  'HISTOLOGICAL_TYPE',  'NUMBER_OF_LYMPH_NODES', and 'ETHNICITY'.

  • del_22q13.32 cnv correlated to 'Time to Death',  'PATHOLOGIC_STAGE',  'PATHOLOGY_N_STAGE',  'PATHOLOGY_M_STAGE',  'HISTOLOGICAL_TYPE', and 'NUMBER_OF_LYMPH_NODES'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between significant copy number variation of 73 focal events and 14 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 355 significant findings detected.

Clinical
Features 		Time
to
Death 		YEARS
TO
BIRTH 		TUMOR
TISSUE
SITE 		PATHOLOGIC
STAGE 		PATHOLOGY
T
STAGE 		PATHOLOGY
N
STAGE 		PATHOLOGY
M
STAGE 		GENDER RADIATION
THERAPY 		HISTOLOGICAL
TYPE 		RESIDUAL
TUMOR 		NUMBER
OF
LYMPH
NODES 		RACE ETHNICITY
nCNV (%) nWild-Type logrank test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Wilcoxon-test Fisher's exact test Fisher's exact test
del 18q21 2 430 (70%) 182 0.524
(0.744) 		0.0521
(0.183) 		3.63e-09
(1.85e-06) 		2e-05
(0.000538) 		0.27
(0.501) 		1e-05
(0.000319) 		9.02e-06
(0.000319) 		0.0631
(0.212) 		0.0866
(0.25) 		1e-05
(0.000319) 		0.064
(0.213) 		6.3e-06
(0.000319) 		0.645
(0.829) 		1
(1.00)
del 8p23 2 288 (47%) 324 0.177
(0.386) 		0.154
(0.359) 		7.37e-05
(0.00138) 		3e-05
(0.000748) 		0.0669
(0.218) 		1e-05
(0.000319) 		6.7e-05
(0.00132) 		0.0353
(0.145) 		0.698
(0.853) 		2e-05
(0.000538) 		0.00599
(0.0434) 		4.21e-06
(0.000319) 		0.535
(0.751) 		0.191
(0.403)
del 8p22 301 (49%) 311 0.0298
(0.132) 		0.172
(0.379) 		0.000931
(0.0101) 		1e-05
(0.000319) 		0.0226
(0.109) 		1e-05
(0.000319) 		2.32e-05
(0.000608) 		0.145
(0.347) 		0.697
(0.853) 		9e-05
(0.00164) 		0.0045
(0.0354) 		7.99e-08
(2.72e-05) 		0.24
(0.47) 		0.371
(0.605)
del 18q12 2 413 (67%) 199 0.479
(0.703) 		0.0359
(0.145) 		1.48e-09
(1.51e-06) 		0.0004
(0.00551) 		0.284
(0.517) 		0.00013
(0.00214) 		0.000406
(0.00551) 		0.195
(0.409) 		0.0371
(0.148) 		1e-05
(0.000319) 		0.0631
(0.212) 		0.000533
(0.00665) 		0.38
(0.613) 		1
(1.00)
amp 13q12 13 399 (65%) 213 0.77
(0.904) 		0.446
(0.677) 		0.000731
(0.00849) 		7e-05
(0.00135) 		0.797
(0.914) 		1e-05
(0.000319) 		0.00212
(0.0197) 		0.611
(0.803) 		0.22
(0.444) 		1e-05
(0.000319) 		0.0402
(0.156) 		4.28e-05
(0.000972) 		0.0215
(0.106) 		1
(1.00)
amp 13q12 2 394 (64%) 218 0.9
(0.973) 		0.393
(0.629) 		0.000553
(0.00673) 		0.0001
(0.0017) 		0.839
(0.936) 		6e-05
(0.0012) 		0.00711
(0.0487) 		0.447
(0.677) 		0.216
(0.44) 		1e-05
(0.000319) 		0.0712
(0.221) 		5.39e-05
(0.0011) 		0.0271
(0.124) 		1
(1.00)
del 18p11 31 368 (60%) 244 0.391
(0.626) 		0.0221
(0.107) 		2.63e-06
(0.000319) 		0.00012
(0.00201) 		0.861
(0.95) 		0.00898
(0.0579) 		7.53e-06
(0.000319) 		0.564
(0.771) 		0.842
(0.939) 		1e-05
(0.000319) 		0.0398
(0.155) 		0.0178
(0.0913) 		0.783
(0.908) 		0.652
(0.83)
del 18q22 1 425 (69%) 187 0.649
(0.83) 		0.132
(0.328) 		1.68e-07
(4.3e-05) 		4e-05
(0.000951) 		0.387
(0.623) 		5e-05
(0.00106) 		1.92e-05
(0.000538) 		0.0787
(0.234) 		0.0867
(0.25) 		1e-05
(0.000319) 		0.118
(0.307) 		5.17e-05
(0.00108) 		0.351
(0.584) 		1
(1.00)
amp 5p12 117 (19%) 495 0.208
(0.43) 		0.167
(0.379) 		0.0477
(0.175) 		0.187
(0.398) 		0.505
(0.727) 		0.0599
(0.204) 		0.0369
(0.148) 		0.607
(0.802) 		0.0839
(0.246) 		0.0158
(0.0839) 		0.0681
(0.219) 		0.0133
(0.0746) 		0.634
(0.82) 		1
(1.00)
amp 6p21 1 154 (25%) 458 0.826
(0.93) 		0.796
(0.914) 		0.0258
(0.121) 		0.00673
(0.0471) 		0.3
(0.532) 		0.00015
(0.0024) 		0.0151
(0.0815) 		0.192
(0.404) 		0.0666
(0.218) 		0.00677
(0.0471) 		0.137
(0.335) 		0.000213
(0.0033) 		0.156
(0.36) 		0.331
(0.565)
amp 7p21 3 361 (59%) 251 0.818
(0.93) 		0.0766
(0.23) 		0.025
(0.119) 		4e-05
(0.000951) 		0.906
(0.977) 		2e-05
(0.000538) 		0.0128
(0.0731) 		0.869
(0.955) 		0.172
(0.379) 		0.00034
(0.00496) 		0.365
(0.599) 		9.93e-05
(0.0017) 		0.727
(0.874) 		1
(1.00)
amp 20q11 21 466 (76%) 146 0.94
(1.00) 		0.726
(0.874) 		4.86e-06
(0.000319) 		0.00275
(0.0242) 		0.214
(0.44) 		0.00088
(0.01) 		0.00596
(0.0434) 		0.218
(0.442) 		0.26
(0.488) 		1e-05
(0.000319) 		0.0702
(0.22) 		0.00482
(0.037) 		0.322
(0.557) 		1
(1.00)
amp 20q12 468 (76%) 144 0.778
(0.906) 		0.624
(0.816) 		2.51e-06
(0.000319) 		0.00097
(0.0104) 		0.289
(0.522) 		0.00038
(0.00539) 		0.000893
(0.01) 		0.252
(0.482) 		0.259
(0.488) 		1e-05
(0.000319) 		0.0699
(0.22) 		0.00503
(0.0381) 		0.212
(0.436) 		1
(1.00)
amp 20q13 31 470 (77%) 142 0.83
(0.932) 		0.567
(0.771) 		2.52e-06
(0.000319) 		0.0014
(0.014) 		0.178
(0.388) 		0.00049
(0.00634) 		0.00135
(0.0138) 		0.443
(0.674) 		0.26
(0.488) 		1e-05
(0.000319) 		0.0675
(0.219) 		0.00461
(0.036) 		0.168
(0.379) 		1
(1.00)
del 3p26 3 92 (15%) 520 0.0151
(0.0815) 		0.605
(0.801) 		0.366
(0.599) 		0.0253
(0.12) 		0.0783
(0.233) 		0.0189
(0.0955) 		0.000468
(0.00613) 		0.498
(0.719) 		0.598
(0.797) 		0.0469
(0.173) 		0.0903
(0.259) 		0.00759
(0.051) 		0.642
(0.826) 		0.175
(0.384)
del 4p16 2 199 (33%) 413 0.322
(0.557) 		0.893
(0.97) 		0.0774
(0.231) 		0.00232
(0.0212) 		0.836
(0.934) 		0.00053
(0.00665) 		0.000424
(0.00563) 		0.12
(0.309) 		0.0116
(0.0679) 		0.0333
(0.141) 		0.104
(0.283) 		0.00015
(0.0024) 		0.335
(0.567) 		0.17
(0.379)
del 4q22 1 221 (36%) 391 0.345
(0.579) 		0.253
(0.483) 		0.0217
(0.106) 		0.0413
(0.158) 		0.146
(0.348) 		0.00041
(0.00551) 		0.113
(0.299) 		0.077
(0.231) 		0.07
(0.22) 		0.00339
(0.0289) 		0.754
(0.892) 		0.000164
(0.00258) 		0.554
(0.768) 		0.364
(0.599)
del 10q23 31 159 (26%) 453 0.285
(0.517) 		0.00466
(0.0361) 		0.0751
(0.23) 		0.0508
(0.181) 		0.544
(0.758) 		0.0591
(0.202) 		0.187
(0.398) 		1
(1.00) 		0.0279
(0.125) 		0.0216
(0.106) 		0.758
(0.894) 		0.0121
(0.0698) 		0.915
(0.984) 		0.137
(0.335)
del 15q22 33 237 (39%) 375 0.54
(0.755) 		0.399
(0.635) 		0.0186
(0.0945) 		0.0146
(0.0791) 		0.0854
(0.249) 		0.0037
(0.031) 		0.0041
(0.0331) 		0.319
(0.556) 		0.11
(0.293) 		0.0132
(0.0746) 		0.575
(0.779) 		0.000932
(0.0101) 		0.12
(0.309) 		1
(1.00)
amp 13q22 1 396 (65%) 216 0.744
(0.886) 		0.752
(0.892) 		0.0167
(0.0875) 		0.00092
(0.0101) 		0.675
(0.841) 		3e-05
(0.000748) 		0.0108
(0.0658) 		0.204
(0.424) 		0.154
(0.359) 		1e-05
(0.000319) 		0.216
(0.44) 		0.000254
(0.00387) 		0.0906
(0.259) 		1
(1.00)
del 1p36 11 242 (40%) 370 0.0935
(0.264) 		0.0677
(0.219) 		0.091
(0.259) 		0.00344
(0.0291) 		0.292
(0.525) 		0.00392
(0.032) 		4.26e-05
(0.000972) 		0.136
(0.335) 		0.426
(0.656) 		0.00168
(0.0165) 		0.124
(0.318) 		0.000507
(0.00648) 		0.32
(0.556) 		1
(1.00)
del 1p33 175 (29%) 437 0.0268
(0.123) 		0.722
(0.871) 		0.36
(0.594) 		0.0329
(0.14) 		0.272
(0.502) 		0.0318
(0.137) 		0.0137
(0.0758) 		0.475
(0.699) 		0.398
(0.635) 		0.0142
(0.0779) 		0.372
(0.605) 		0.00714
(0.0487) 		0.256
(0.485) 		0.155
(0.359)
del 1p13 2 174 (28%) 438 0.0262
(0.122) 		0.882
(0.965) 		0.222
(0.444) 		0.00774
(0.0517) 		0.154
(0.359) 		0.0114
(0.0676) 		0.00965
(0.0603) 		0.42
(0.651) 		0.389
(0.625) 		0.0705
(0.22) 		0.459
(0.689) 		0.000694
(0.00815) 		0.422
(0.653) 		0.634
(0.82)
del 4q35 1 230 (38%) 382 0.779
(0.906) 		0.172
(0.379) 		0.107
(0.288) 		0.0685
(0.22) 		0.601
(0.799) 		0.00104
(0.0111) 		0.0712
(0.221) 		0.933
(0.997) 		0.0446
(0.167) 		0.0644
(0.214) 		0.798
(0.915) 		0.000309
(0.00464) 		0.259
(0.488) 		0.377
(0.611)
del 5q12 1 158 (26%) 454 0.297
(0.53) 		0.193
(0.404) 		0.0278
(0.125) 		0.0303
(0.133) 		0.982
(1.00) 		0.0355
(0.145) 		0.0104
(0.0643) 		0.58
(0.784) 		0.83
(0.932) 		0.0106
(0.0655) 		0.66
(0.833) 		0.0182
(0.093) 		0.279
(0.511) 		0.137
(0.335)
del 6q26 91 (15%) 521 0.0313
(0.136) 		0.702
(0.855) 		0.299
(0.532) 		0.205
(0.424) 		0.169
(0.379) 		0.00118
(0.0123) 		0.0943
(0.264) 		0.212
(0.436) 		0.0522
(0.183) 		0.0337
(0.142) 		0.176
(0.385) 		0.00233
(0.0212) 		0.0142
(0.0779) 		1
(1.00)
del 15q15 2 250 (41%) 362 0.602
(0.799) 		0.27
(0.501) 		0.0401
(0.156) 		0.0629
(0.212) 		0.831
(0.932) 		0.007
(0.0483) 		0.00442
(0.035) 		0.249
(0.48) 		0.112
(0.297) 		0.0198
(0.0993) 		0.54
(0.755) 		0.00321
(0.0276) 		0.186
(0.397) 		1
(1.00)
del 15q21 1 247 (40%) 365 0.44
(0.673) 		0.588
(0.788) 		0.0316
(0.137) 		0.132
(0.328) 		0.82
(0.93) 		0.0267
(0.123) 		0.00868
(0.0565) 		0.161
(0.368) 		0.075
(0.23) 		0.019
(0.0958) 		0.451
(0.682) 		0.0109
(0.0661) 		0.139
(0.336) 		1
(1.00)
del 17p12 367 (60%) 245 0.675
(0.841) 		0.229
(0.453) 		0.00271
(0.0242) 		0.00037
(0.00533) 		0.403
(0.637) 		2e-05
(0.000538) 		0.00273
(0.0242) 		0.409
(0.642) 		1
(1.00) 		1e-05
(0.000319) 		0.217
(0.44) 		1.53e-05
(0.000475) 		0.794
(0.913) 		0.652
(0.83)
del 19p13 3 96 (16%) 516 0.326
(0.56) 		0.251
(0.482) 		0.0583
(0.201) 		0.00586
(0.0434) 		0.409
(0.642) 		5e-05
(0.00106) 		0.00667
(0.047) 		0.268
(0.499) 		0.285
(0.517) 		0.0865
(0.25) 		0.168
(0.379) 		5.08e-06
(0.000319) 		0.837
(0.935) 		0.536
(0.751)
del 22q13 32 227 (37%) 385 0.065
(0.215) 		0.852
(0.946) 		0.254
(0.483) 		0.00437
(0.0349) 		0.366
(0.599) 		0.00032
(0.00474) 		0.00756
(0.051) 		0.402
(0.637) 		0.844
(0.939) 		0.00664
(0.047) 		0.509
(0.73) 		0.000389
(0.00544) 		0.463
(0.691) 		0.351
(0.584)
amp 1q31 1 145 (24%) 467 0.413
(0.643) 		0.332
(0.566) 		0.0657
(0.216) 		0.327
(0.561) 		0.373
(0.605) 		0.0828
(0.244) 		0.0524
(0.184) 		0.216
(0.44) 		0.0705
(0.22) 		0.145
(0.347) 		0.79
(0.911) 		0.016
(0.0842) 		0.931
(0.996) 		1
(1.00)
amp 2q33 1 140 (23%) 472 0.141
(0.342) 		0.895
(0.971) 		0.0123
(0.0708) 		0.0413
(0.158) 		0.761
(0.895) 		0.00089
(0.01) 		0.259
(0.488) 		1
(1.00) 		0.0977
(0.271) 		0.00186
(0.0178) 		0.419
(0.65) 		0.00293
(0.0256) 		0.181
(0.392) 		0.11
(0.293)
amp 8q12 1 329 (54%) 283 0.656
(0.83) 		0.0844
(0.246) 		0.358
(0.591) 		0.0378
(0.149) 		0.271
(0.501) 		0.0942
(0.264) 		0.00493
(0.0376) 		0.417
(0.648) 		0.245
(0.479) 		0.0119
(0.0693) 		0.0636
(0.212) 		0.0892
(0.256) 		0.432
(0.662) 		1
(1.00)
amp 16p11 2 172 (28%) 440 0.552
(0.767) 		0.464
(0.691) 		0.761
(0.895) 		0.00175
(0.0169) 		0.735
(0.881) 		0.0001
(0.0017) 		0.05
(0.179) 		1
(1.00) 		0.674
(0.841) 		0.00055
(0.00673) 		0.324
(0.559) 		7.42e-05
(0.00138) 		0.56
(0.768) 		0.622
(0.815)
amp 20p12 1 278 (45%) 334 0.631
(0.819) 		0.586
(0.788) 		0.167
(0.379) 		0.0133
(0.0746) 		0.863
(0.951) 		0.0948
(0.264) 		0.000643
(0.00764) 		0.0344
(0.143) 		0.05
(0.179) 		0.0111
(0.0666) 		0.106
(0.286) 		0.138
(0.335) 		0.754
(0.892) 		1
(1.00)
amp 20p11 21 362 (59%) 250 0.994
(1.00) 		0.828
(0.931) 		0.009
(0.0579) 		0.0215
(0.106) 		0.678
(0.842) 		0.432
(0.662) 		0.00136
(0.0138) 		0.0582
(0.201) 		0.17
(0.379) 		1e-05
(0.000319) 		0.476
(0.701) 		0.767
(0.902) 		0.86
(0.95) 		0.652
(0.83)
del 5q21 2 186 (30%) 426 0.138
(0.335) 		0.198
(0.414) 		0.319
(0.556) 		0.00965
(0.0603) 		0.818
(0.93) 		0.00154
(0.0153) 		0.0107
(0.0655) 		0.86
(0.95) 		1
(1.00) 		0.0766
(0.23) 		0.676
(0.841) 		0.00174
(0.0169) 		0.555
(0.768) 		0.181
(0.392)
del 5q22 2 188 (31%) 424 0.109
(0.291) 		0.486
(0.705) 		0.0913
(0.259) 		0.0496
(0.179) 		0.78
(0.906) 		0.037
(0.148) 		0.0158
(0.0839) 		0.381
(0.614) 		0.532
(0.749) 		0.0589
(0.202) 		0.335
(0.567) 		0.0234
(0.112) 		0.581
(0.784) 		0.181
(0.392)
del 10p15 3 112 (18%) 500 0.334
(0.567) 		0.0319
(0.137) 		0.288
(0.521) 		0.045
(0.167) 		0.632
(0.819) 		0.0233
(0.112) 		0.0357
(0.145) 		0.755
(0.892) 		0.138
(0.335) 		0.4
(0.635) 		0.869
(0.955) 		0.00412
(0.0331) 		0.514
(0.735) 		1
(1.00)
del 10q21 1 137 (22%) 475 0.978
(1.00) 		0.0474
(0.174) 		0.441
(0.673) 		0.13
(0.327) 		0.898
(0.973) 		0.116
(0.304) 		0.128
(0.326) 		0.698
(0.853) 		0.00209
(0.0196) 		0.0353
(0.145) 		0.317
(0.553) 		0.0393
(0.154) 		0.682
(0.844) 		0.0113
(0.0675)
del 10q25 2 155 (25%) 457 0.575
(0.779) 		0.0493
(0.179) 		0.208
(0.43) 		0.259
(0.488) 		0.284
(0.517) 		0.0309
(0.135) 		0.188
(0.399) 		1
(1.00) 		0.0413
(0.158) 		0.0302
(0.133) 		0.753
(0.892) 		0.0173
(0.0893) 		0.976
(1.00) 		0.608
(0.803)
del 14q31 1 215 (35%) 397 0.703
(0.855) 		0.152
(0.357) 		0.0345
(0.143) 		0.485
(0.705) 		0.222
(0.444) 		0.0342
(0.143) 		0.0288
(0.128) 		0.27
(0.501) 		0.311
(0.545) 		1e-05
(0.000319) 		0.805
(0.921) 		0.0486
(0.178) 		0.981
(1.00) 		1
(1.00)
del 17q24 3 95 (16%) 517 0.0759
(0.23) 		0.246
(0.479) 		1
(1.00) 		0.00594
(0.0434) 		0.0939
(0.264) 		0.0012
(0.0124) 		0.0136
(0.0753) 		0.221
(0.444) 		0.786
(0.91) 		1
(1.00) 		0.407
(0.642) 		9.25e-05
(0.00166) 		0.186
(0.397) 		1
(1.00)
amp 8q24 21 366 (60%) 246 0.23
(0.453) 		0.137
(0.335) 		0.0753
(0.23) 		0.0498
(0.179) 		0.265
(0.494) 		0.144
(0.346) 		0.00863
(0.0565) 		0.216
(0.44) 		0.559
(0.768) 		0.00936
(0.0598) 		0.148
(0.351) 		0.162
(0.37) 		0.616
(0.808) 		1
(1.00)
del 6p25 3 79 (13%) 533 0.135
(0.335) 		0.0449
(0.167) 		0.89
(0.97) 		0.373
(0.605) 		0.467
(0.694) 		0.484
(0.705) 		1
(1.00) 		0.0541
(0.188) 		0.0831
(0.244) 		0.468
(0.694) 		0.452
(0.683) 		0.455
(0.685) 		0.00817
(0.0542) 		1
(1.00)
del 9p24 2 83 (14%) 529 0.16
(0.367) 		0.132
(0.328) 		0.283
(0.517) 		0.825
(0.93) 		0.601
(0.799) 		0.145
(0.347) 		0.0671
(0.218) 		0.0439
(0.165) 		0.778
(0.906) 		0.0386
(0.152) 		0.15
(0.355) 		0.0449
(0.167) 		0.703
(0.855) 		0.143
(0.346)
del 11q22 3 110 (18%) 502 0.49
(0.71) 		0.405
(0.64) 		0.0697
(0.22) 		0.687
(0.847) 		0.72
(0.87) 		0.171
(0.379) 		0.443
(0.674) 		0.673
(0.841) 		0.0759
(0.23) 		0.0419
(0.16) 		0.582
(0.784) 		0.0663
(0.218) 		0.23
(0.453) 		0.588
(0.788)
del 12p13 1 91 (15%) 521 0.0631
(0.212) 		0.281
(0.513) 		0.153
(0.359) 		0.177
(0.386) 		0.743
(0.886) 		0.0262
(0.122) 		0.043
(0.163) 		0.82
(0.93) 		0.791
(0.911) 		0.0155
(0.083) 		0.903
(0.976) 		0.119
(0.309) 		0.964
(1.00) 		1
(1.00)
del 12q21 33 89 (15%) 523 0.0721
(0.223) 		0.92
(0.989) 		0.363
(0.597) 		0.0517
(0.183) 		0.571
(0.776) 		0.101
(0.276) 		0.248
(0.479) 		0.567
(0.771) 		0.791
(0.911) 		0.0273
(0.124) 		0.515
(0.735) 		0.0258
(0.121) 		0.962
(1.00) 		0.559
(0.768)
del 15q11 2 252 (41%) 360 0.53
(0.748) 		0.484
(0.705) 		0.162
(0.371) 		0.0947
(0.264) 		0.785
(0.91) 		0.022
(0.107) 		0.0328
(0.14) 		0.324
(0.559) 		0.173
(0.38) 		0.0763
(0.23) 		0.811
(0.927) 		0.00509
(0.0383) 		0.334
(0.567) 		1
(1.00)
del 21q11 2 212 (35%) 400 0.338
(0.568) 		0.715
(0.865) 		0.00374
(0.0311) 		0.41
(0.642) 		0.912
(0.983) 		0.0974
(0.27) 		0.391
(0.626) 		0.61
(0.803) 		0.412
(0.643) 		5e-05
(0.00106) 		0.664
(0.834) 		0.0263
(0.122) 		0.556
(0.768) 		0.0535
(0.186)
amp 11p15 5 136 (22%) 476 0.529
(0.748) 		0.0283
(0.126) 		0.0765
(0.23) 		0.807
(0.923) 		0.228
(0.452) 		0.307
(0.542) 		0.331
(0.565) 		0.697
(0.853) 		0.482
(0.705) 		0.00112
(0.0118) 		0.885
(0.968) 		0.251
(0.482) 		0.516
(0.735) 		1
(1.00)
amp 17q12 160 (26%) 452 0.0718
(0.222) 		0.184
(0.395) 		0.532
(0.749) 		0.293
(0.526) 		0.183
(0.394) 		0.167
(0.379) 		0.00305
(0.0264) 		0.0982
(0.271) 		0.663
(0.834) 		0.293
(0.526) 		0.0695
(0.22) 		0.251
(0.482) 		0.148
(0.351) 		0.117
(0.305)
amp 17q24 1 144 (24%) 468 0.00967
(0.0603) 		0.26
(0.488) 		1
(1.00) 		0.662
(0.833) 		0.738
(0.883) 		0.93
(0.996) 		0.0704
(0.22) 		0.703
(0.855) 		0.823
(0.93) 		0.0815
(0.241) 		0.122
(0.314) 		0.637
(0.822) 		0.686
(0.846) 		0.104
(0.283)
del 2p12 21 (3%) 591 0.778
(0.906) 		0.13
(0.327) 		0.000581
(0.00698) 		0.33
(0.565) 		1
(1.00) 		0.471
(0.697) 		0.756
(0.893) 		0.661
(0.833) 		0.0829
(0.244) 		0.00645
(0.0464) 		0.887
(0.968) 		0.399
(0.635) 		0.675
(0.841) 		1
(1.00)
del 3q26 31 63 (10%) 549 0.564
(0.771) 		0.677
(0.841) 		0.88
(0.964) 		0.0364
(0.147) 		0.0996
(0.274) 		0.13
(0.327) 		0.0378
(0.149) 		0.355
(0.589) 		0.347
(0.582) 		0.00945
(0.06) 		0.824
(0.93) 		0.161
(0.368) 		0.651
(0.83) 		1
(1.00)
del 14q11 2 209 (34%) 403 0.752
(0.892) 		0.29
(0.524) 		0.0119
(0.0693) 		0.69
(0.85) 		0.32
(0.556) 		0.0428
(0.163) 		0.112
(0.297) 		0.865
(0.952) 		0.155
(0.359) 		1e-05
(0.000319) 		0.817
(0.93) 		0.169
(0.379) 		1
(1.00) 		1
(1.00)
del 16p13 3 68 (11%) 544 0.00665
(0.047) 		0.906
(0.977) 		0.148
(0.351) 		0.0132
(0.0746) 		0.052
(0.183) 		0.226
(0.449) 		0.261
(0.489) 		0.699
(0.854) 		0.559
(0.768) 		0.222
(0.444) 		0.429
(0.659) 		0.13
(0.327) 		0.301
(0.533) 		0.471
(0.697)
del 20p12 1 133 (22%) 479 0.939
(1.00) 		0.41
(0.642) 		0.00538
(0.0401) 		0.19
(0.402) 		0.75
(0.892) 		0.239
(0.469) 		1
(1.00) 		0.624
(0.816) 		0.626
(0.816) 		0.0019
(0.018) 		0.558
(0.768) 		0.0618
(0.21) 		0.221
(0.444) 		1
(1.00)
amp 5q22 3 65 (11%) 547 0.184
(0.395) 		0.63
(0.819) 		0.458
(0.689) 		0.652
(0.83) 		0.939
(1.00) 		0.455
(0.685) 		0.0378
(0.149) 		0.896
(0.971) 		0.533
(0.749) 		0.218
(0.442) 		0.0691
(0.22) 		0.276
(0.508) 		0.537
(0.751) 		0.436
(0.667)
amp 15q26 1 42 (7%) 570 0.425
(0.656) 		0.775
(0.906) 		0.587
(0.788) 		0.279
(0.511) 		0.35
(0.584) 		0.0027
(0.0242) 		0.654
(0.83) 		0.2
(0.418) 		0.409
(0.642) 		0.52
(0.739) 		0.473
(0.699) 		0.0039
(0.032) 		0.602
(0.799) 		1
(1.00)
amp 19q12 139 (23%) 473 0.427
(0.657) 		0.55
(0.765) 		0.155
(0.359) 		0.592
(0.791) 		0.825
(0.93) 		0.107
(0.288) 		0.0169
(0.0883) 		0.247
(0.479) 		0.482
(0.705) 		0.0202
(0.101) 		0.465
(0.691) 		0.278
(0.511) 		0.669
(0.839) 		0.599
(0.798)
del 7q31 1 17 (3%) 595 0.638
(0.822) 		0.681
(0.844) 		1
(1.00) 		0.856
(0.948) 		0.46
(0.69) 		0.844
(0.939) 		1
(1.00) 		0.631
(0.819) 		0.0434
(0.164) 		0.498
(0.719) 		0.656
(0.83) 		0.561
(0.768) 		0.794
(0.913) 		0.00841
(0.0554)
del 8q11 1 47 (8%) 565 0.698
(0.853) 		0.307
(0.542) 		0.224
(0.446) 		0.136
(0.335) 		0.693
(0.852) 		0.0589
(0.202) 		0.129
(0.326) 		0.228
(0.452) 		0.714
(0.864) 		0.542
(0.756) 		0.348
(0.582) 		0.0274
(0.124) 		0.103
(0.281) 		1
(1.00)
amp 8p11 21 254 (42%) 358 0.611
(0.803) 		0.463
(0.691) 		0.71
(0.862) 		0.171
(0.379) 		0.509
(0.73) 		0.352
(0.584) 		0.123
(0.317) 		0.189
(0.401) 		1
(1.00) 		0.17
(0.379) 		0.0347
(0.143) 		0.517
(0.735) 		0.444
(0.675) 		0.4
(0.635)
amp 12p13 32 150 (25%) 462 0.252
(0.482) 		0.131
(0.327) 		0.831
(0.932) 		0.109
(0.292) 		0.38
(0.613) 		0.0858
(0.249) 		0.892
(0.97) 		0.851
(0.945) 		0.36
(0.594) 		0.513
(0.734) 		0.733
(0.88) 		0.316
(0.553) 		0.646
(0.83) 		0.343
(0.576)
amp 19p13 2 111 (18%) 501 0.778
(0.906) 		0.74
(0.883) 		0.154
(0.359) 		0.738
(0.883) 		0.525
(0.744) 		0.108
(0.291) 		0.356
(0.589) 		0.295
(0.528) 		0.204
(0.424) 		0.0496
(0.179) 		0.114
(0.299) 		0.414
(0.644) 		0.528
(0.747) 		0.588
(0.788)
del 2q22 1 35 (6%) 577 0.682
(0.844) 		0.834
(0.934) 		0.555
(0.768) 		0.31
(0.544) 		0.651
(0.83) 		0.573
(0.777) 		0.333
(0.567) 		0.728
(0.874) 		1
(1.00) 		0.892
(0.97) 		0.929
(0.996) 		0.242
(0.473) 		0.0114
(0.0676) 		1
(1.00)
del 3p14 2 118 (19%) 494 0.182
(0.393) 		0.336
(0.567) 		0.727
(0.874) 		0.263
(0.492) 		0.119
(0.309) 		0.301
(0.533) 		0.0172
(0.0893) 		0.412
(0.643) 		1
(1.00) 		0.654
(0.83) 		0.368
(0.6) 		0.109
(0.291) 		0.483
(0.705) 		1
(1.00)
del 16q23 1 83 (14%) 529 0.0337
(0.142) 		0.513
(0.734) 		0.791
(0.911) 		0.327
(0.561) 		0.22
(0.444) 		0.495
(0.717) 		0.308
(0.542) 		0.48
(0.704) 		1
(1.00) 		0.813
(0.927) 		0.879
(0.964) 		0.891
(0.97) 		0.248
(0.479) 		0.129
(0.326)
amp 8p11 23 210 (34%) 402 0.966
(1.00) 		0.779
(0.906) 		0.63
(0.819) 		0.247
(0.479) 		0.592
(0.791) 		0.507
(0.729) 		0.711
(0.862) 		0.609
(0.803) 		0.683
(0.844) 		0.231
(0.454) 		0.0943
(0.264) 		0.777
(0.906) 		0.662
(0.833) 		0.656
(0.83)
amp 10q22 3 40 (7%) 572 0.825
(0.93) 		0.464
(0.691) 		0.855
(0.948) 		0.565
(0.771) 		0.295
(0.528) 		0.0997
(0.274) 		0.475
(0.699) 		0.625
(0.816) 		0.177
(0.386) 		0.932
(0.996) 		0.87
(0.955) 		0.125
(0.32) 		0.922
(0.99) 		0.298
(0.531)
'amp_1q31.1' versus 'TUMOR_TISSUE_SITE'

P value = 0.0657 (Fisher's exact test), Q value = 0.22

Table S1.  Gene #1: 'amp_1q31.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 1(1Q31.1) MUTATED 96 47
AMP PEAK 1(1Q31.1) WILD-TYPE 350 115

Figure S1.  Get High-res Image Gene #1: 'amp_1q31.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_1q31.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.0828 (Fisher's exact test), Q value = 0.24

Table S2.  Gene #1: 'amp_1q31.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 1(1Q31.1) MUTATED 70 39 34
AMP PEAK 1(1Q31.1) WILD-TYPE 275 111 81

Figure S2.  Get High-res Image Gene #1: 'amp_1q31.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_1q31.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.0524 (Fisher's exact test), Q value = 0.18

Table S3.  Gene #1: 'amp_1q31.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 1(1Q31.1) MUTATED 97 28
AMP PEAK 1(1Q31.1) WILD-TYPE 353 60

Figure S3.  Get High-res Image Gene #1: 'amp_1q31.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_1q31.1' versus 'RADIATION_THERAPY'

P value = 0.0705 (Fisher's exact test), Q value = 0.22

Table S4.  Gene #1: 'amp_1q31.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
AMP PEAK 1(1Q31.1) MUTATED 105 11
AMP PEAK 1(1Q31.1) WILD-TYPE 341 17

Figure S4.  Get High-res Image Gene #1: 'amp_1q31.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

'amp_1q31.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.016 (Wilcoxon-test), Q value = 0.084

Table S5.  Gene #1: 'amp_1q31.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 1(1Q31.1) MUTATED 137 3.1 (5.6)
AMP PEAK 1(1Q31.1) WILD-TYPE 439 2.0 (4.4)

Figure S5.  Get High-res Image Gene #1: 'amp_1q31.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_2q33.1' versus 'TUMOR_TISSUE_SITE'

P value = 0.0123 (Fisher's exact test), Q value = 0.071

Table S6.  Gene #2: 'amp_2q33.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 2(2Q33.1) MUTATED 91 49
AMP PEAK 2(2Q33.1) WILD-TYPE 355 113

Figure S6.  Get High-res Image Gene #2: 'amp_2q33.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_2q33.1' versus 'PATHOLOGIC_STAGE'

P value = 0.0413 (Fisher's exact test), Q value = 0.16

Table S7.  Gene #2: 'amp_2q33.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 2(2Q33.1) MUTATED 21 0 8 29 0 2 6 3 23 21 15 6 1
AMP PEAK 2(2Q33.1) WILD-TYPE 83 1 28 144 10 1 20 15 60 33 48 20 1

Figure S7.  Get High-res Image Gene #2: 'amp_2q33.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_2q33.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00089 (Fisher's exact test), Q value = 0.01

Table S8.  Gene #2: 'amp_2q33.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 2(2Q33.1) MUTATED 63 35 41
AMP PEAK 2(2Q33.1) WILD-TYPE 282 115 74

Figure S8.  Get High-res Image Gene #2: 'amp_2q33.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_2q33.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.00186 (Fisher's exact test), Q value = 0.018

Table S9.  Gene #2: 'amp_2q33.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 2(2Q33.1) MUTATED 81 10 49 0
AMP PEAK 2(2Q33.1) WILD-TYPE 301 50 97 13

Figure S9.  Get High-res Image Gene #2: 'amp_2q33.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_2q33.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00293 (Wilcoxon-test), Q value = 0.026

Table S10.  Gene #2: 'amp_2q33.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 2(2Q33.1) MUTATED 132 3.1 (5.3)
AMP PEAK 2(2Q33.1) WILD-TYPE 444 2.0 (4.5)

Figure S10.  Get High-res Image Gene #2: 'amp_2q33.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_5p12' versus 'TUMOR_TISSUE_SITE'

P value = 0.0477 (Fisher's exact test), Q value = 0.17

Table S11.  Gene #3: 'amp_5p12' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 3(5P12) MUTATED 77 40
AMP PEAK 3(5P12) WILD-TYPE 369 122

Figure S11.  Get High-res Image Gene #3: 'amp_5p12' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_5p12' versus 'PATHOLOGY_N_STAGE'

P value = 0.0599 (Fisher's exact test), Q value = 0.2

Table S12.  Gene #3: 'amp_5p12' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 3(5P12) MUTATED 55 32 29
AMP PEAK 3(5P12) WILD-TYPE 290 118 86

Figure S12.  Get High-res Image Gene #3: 'amp_5p12' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_5p12' versus 'PATHOLOGY_M_STAGE'

P value = 0.0369 (Fisher's exact test), Q value = 0.15

Table S13.  Gene #3: 'amp_5p12' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 3(5P12) MUTATED 78 24
AMP PEAK 3(5P12) WILD-TYPE 372 64

Figure S13.  Get High-res Image Gene #3: 'amp_5p12' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_5p12' versus 'RADIATION_THERAPY'

P value = 0.0839 (Fisher's exact test), Q value = 0.25

Table S14.  Gene #3: 'amp_5p12' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
AMP PEAK 3(5P12) MUTATED 82 9
AMP PEAK 3(5P12) WILD-TYPE 364 19

Figure S14.  Get High-res Image Gene #3: 'amp_5p12' versus Clinical Feature #9: 'RADIATION_THERAPY'

'amp_5p12' versus 'HISTOLOGICAL_TYPE'

P value = 0.0158 (Fisher's exact test), Q value = 0.084

Table S15.  Gene #3: 'amp_5p12' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 3(5P12) MUTATED 68 9 40 0
AMP PEAK 3(5P12) WILD-TYPE 314 51 106 13

Figure S15.  Get High-res Image Gene #3: 'amp_5p12' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_5p12' versus 'RESIDUAL_TUMOR'

P value = 0.0681 (Fisher's exact test), Q value = 0.22

Table S16.  Gene #3: 'amp_5p12' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
AMP PEAK 3(5P12) MUTATED 85 1 13 3
AMP PEAK 3(5P12) WILD-TYPE 357 4 24 26

Figure S16.  Get High-res Image Gene #3: 'amp_5p12' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'amp_5p12' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0133 (Wilcoxon-test), Q value = 0.075

Table S17.  Gene #3: 'amp_5p12' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 3(5P12) MUTATED 113 2.9 (4.7)
AMP PEAK 3(5P12) WILD-TYPE 463 2.1 (4.7)

Figure S17.  Get High-res Image Gene #3: 'amp_5p12' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_5q22.3' versus 'PATHOLOGY_M_STAGE'

P value = 0.0378 (Fisher's exact test), Q value = 0.15

Table S18.  Gene #4: 'amp_5q22.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 4(5Q22.3) MUTATED 42 15
AMP PEAK 4(5Q22.3) WILD-TYPE 408 73

Figure S18.  Get High-res Image Gene #4: 'amp_5q22.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_5q22.3' versus 'RESIDUAL_TUMOR'

P value = 0.0691 (Fisher's exact test), Q value = 0.22

Table S19.  Gene #4: 'amp_5q22.3' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
AMP PEAK 4(5Q22.3) MUTATED 45 0 7 0
AMP PEAK 4(5Q22.3) WILD-TYPE 397 5 30 29

Figure S19.  Get High-res Image Gene #4: 'amp_5q22.3' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'amp_6p21.1' versus 'TUMOR_TISSUE_SITE'

P value = 0.0258 (Fisher's exact test), Q value = 0.12

Table S20.  Gene #5: 'amp_6p21.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 5(6P21.1) MUTATED 100 51
AMP PEAK 5(6P21.1) WILD-TYPE 346 111

Figure S20.  Get High-res Image Gene #5: 'amp_6p21.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_6p21.1' versus 'PATHOLOGIC_STAGE'

P value = 0.00673 (Fisher's exact test), Q value = 0.047

Table S21.  Gene #5: 'amp_6p21.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 5(6P21.1) MUTATED 21 0 4 33 1 1 6 6 26 21 19 12 1
AMP PEAK 5(6P21.1) WILD-TYPE 83 1 32 140 9 2 20 12 57 33 44 14 1

Figure S21.  Get High-res Image Gene #5: 'amp_6p21.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_6p21.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00015 (Fisher's exact test), Q value = 0.0024

Table S22.  Gene #5: 'amp_6p21.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 5(6P21.1) MUTATED 67 41 45
AMP PEAK 5(6P21.1) WILD-TYPE 278 109 70

Figure S22.  Get High-res Image Gene #5: 'amp_6p21.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_6p21.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.0151 (Fisher's exact test), Q value = 0.081

Table S23.  Gene #5: 'amp_6p21.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 5(6P21.1) MUTATED 102 31
AMP PEAK 5(6P21.1) WILD-TYPE 348 57

Figure S23.  Get High-res Image Gene #5: 'amp_6p21.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_6p21.1' versus 'RADIATION_THERAPY'

P value = 0.0666 (Fisher's exact test), Q value = 0.22

Table S24.  Gene #5: 'amp_6p21.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
AMP PEAK 5(6P21.1) MUTATED 103 11
AMP PEAK 5(6P21.1) WILD-TYPE 343 17

Figure S24.  Get High-res Image Gene #5: 'amp_6p21.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

'amp_6p21.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.00677 (Fisher's exact test), Q value = 0.047

Table S25.  Gene #5: 'amp_6p21.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 5(6P21.1) MUTATED 90 9 50 1
AMP PEAK 5(6P21.1) WILD-TYPE 292 51 96 12

Figure S25.  Get High-res Image Gene #5: 'amp_6p21.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_6p21.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000213 (Wilcoxon-test), Q value = 0.0033

Table S26.  Gene #5: 'amp_6p21.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 5(6P21.1) MUTATED 148 3.4 (6.0)
AMP PEAK 5(6P21.1) WILD-TYPE 428 1.8 (4.1)

Figure S26.  Get High-res Image Gene #5: 'amp_6p21.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_7p21.3' versus 'YEARS_TO_BIRTH'

P value = 0.0766 (Wilcoxon-test), Q value = 0.23

Table S27.  Gene #6: 'amp_7p21.3' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
AMP PEAK 6(7P21.3) MUTATED 360 65.7 (12.2)
AMP PEAK 6(7P21.3) WILD-TYPE 250 67.2 (13.5)

Figure S27.  Get High-res Image Gene #6: 'amp_7p21.3' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'amp_7p21.3' versus 'TUMOR_TISSUE_SITE'

P value = 0.025 (Fisher's exact test), Q value = 0.12

Table S28.  Gene #6: 'amp_7p21.3' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 6(7P21.3) MUTATED 251 108
AMP PEAK 6(7P21.3) WILD-TYPE 195 54

Figure S28.  Get High-res Image Gene #6: 'amp_7p21.3' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_7p21.3' versus 'PATHOLOGIC_STAGE'

P value = 4e-05 (Fisher's exact test), Q value = 0.00095

Table S29.  Gene #6: 'amp_7p21.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 6(7P21.3) MUTATED 57 1 19 78 3 2 16 12 63 37 43 20 1
AMP PEAK 6(7P21.3) WILD-TYPE 47 0 17 95 7 1 10 6 20 17 20 6 1

Figure S29.  Get High-res Image Gene #6: 'amp_7p21.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_7p21.3' versus 'PATHOLOGY_N_STAGE'

P value = 2e-05 (Fisher's exact test), Q value = 0.00054

Table S30.  Gene #6: 'amp_7p21.3' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 6(7P21.3) MUTATED 173 109 77
AMP PEAK 6(7P21.3) WILD-TYPE 172 41 38

Figure S30.  Get High-res Image Gene #6: 'amp_7p21.3' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_7p21.3' versus 'PATHOLOGY_M_STAGE'

P value = 0.0128 (Fisher's exact test), Q value = 0.073

Table S31.  Gene #6: 'amp_7p21.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 6(7P21.3) MUTATED 251 62
AMP PEAK 6(7P21.3) WILD-TYPE 199 26

Figure S31.  Get High-res Image Gene #6: 'amp_7p21.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_7p21.3' versus 'HISTOLOGICAL_TYPE'

P value = 0.00034 (Fisher's exact test), Q value = 0.005

Table S32.  Gene #6: 'amp_7p21.3' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 6(7P21.3) MUTATED 226 24 102 5
AMP PEAK 6(7P21.3) WILD-TYPE 156 36 44 8

Figure S32.  Get High-res Image Gene #6: 'amp_7p21.3' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_7p21.3' versus 'NUMBER_OF_LYMPH_NODES'

P value = 9.93e-05 (Wilcoxon-test), Q value = 0.0017

Table S33.  Gene #6: 'amp_7p21.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 6(7P21.3) MUTATED 342 2.6 (5.1)
AMP PEAK 6(7P21.3) WILD-TYPE 234 1.7 (4.0)

Figure S33.  Get High-res Image Gene #6: 'amp_7p21.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_8p11.21' versus 'RESIDUAL_TUMOR'

P value = 0.0347 (Fisher's exact test), Q value = 0.14

Table S34.  Gene #8: 'amp_8p11.21' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
AMP PEAK 8(8P11.21) MUTATED 173 2 22 16
AMP PEAK 8(8P11.21) WILD-TYPE 269 3 15 13

Figure S34.  Get High-res Image Gene #8: 'amp_8p11.21' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'amp_8q12.1' versus 'YEARS_TO_BIRTH'

P value = 0.0844 (Wilcoxon-test), Q value = 0.25

Table S35.  Gene #9: 'amp_8q12.1' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
AMP PEAK 9(8Q12.1) MUTATED 328 65.6 (12.4)
AMP PEAK 9(8Q12.1) WILD-TYPE 282 67.0 (13.2)

Figure S35.  Get High-res Image Gene #9: 'amp_8q12.1' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'amp_8q12.1' versus 'PATHOLOGIC_STAGE'

P value = 0.0378 (Fisher's exact test), Q value = 0.15

Table S36.  Gene #9: 'amp_8q12.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 9(8Q12.1) MUTATED 48 0 22 87 4 3 11 10 45 33 45 14 0
AMP PEAK 9(8Q12.1) WILD-TYPE 56 1 14 86 6 0 15 8 38 21 18 12 2

Figure S36.  Get High-res Image Gene #9: 'amp_8q12.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_8q12.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.00493 (Fisher's exact test), Q value = 0.038

Table S37.  Gene #9: 'amp_8q12.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 9(8Q12.1) MUTATED 227 59
AMP PEAK 9(8Q12.1) WILD-TYPE 223 29

Figure S37.  Get High-res Image Gene #9: 'amp_8q12.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_8q12.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0119 (Fisher's exact test), Q value = 0.069

Table S38.  Gene #9: 'amp_8q12.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 9(8Q12.1) MUTATED 212 23 87 4
AMP PEAK 9(8Q12.1) WILD-TYPE 170 37 59 9

Figure S38.  Get High-res Image Gene #9: 'amp_8q12.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_8q12.1' versus 'RESIDUAL_TUMOR'

P value = 0.0636 (Fisher's exact test), Q value = 0.21

Table S39.  Gene #9: 'amp_8q12.1' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
AMP PEAK 9(8Q12.1) MUTATED 227 3 27 17
AMP PEAK 9(8Q12.1) WILD-TYPE 215 2 10 12

Figure S39.  Get High-res Image Gene #9: 'amp_8q12.1' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'amp_8q24.21' versus 'TUMOR_TISSUE_SITE'

P value = 0.0753 (Fisher's exact test), Q value = 0.23

Table S40.  Gene #10: 'amp_8q24.21' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 10(8Q24.21) MUTATED 258 107
AMP PEAK 10(8Q24.21) WILD-TYPE 188 55

Figure S40.  Get High-res Image Gene #10: 'amp_8q24.21' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_8q24.21' versus 'PATHOLOGIC_STAGE'

P value = 0.0498 (Fisher's exact test), Q value = 0.18

Table S41.  Gene #10: 'amp_8q24.21' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 10(8Q24.21) MUTATED 56 0 24 98 4 3 13 13 49 34 48 16 0
AMP PEAK 10(8Q24.21) WILD-TYPE 48 1 12 75 6 0 13 5 34 20 15 10 2

Figure S41.  Get High-res Image Gene #10: 'amp_8q24.21' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_8q24.21' versus 'PATHOLOGY_M_STAGE'

P value = 0.00863 (Fisher's exact test), Q value = 0.057

Table S42.  Gene #10: 'amp_8q24.21' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 10(8Q24.21) MUTATED 258 64
AMP PEAK 10(8Q24.21) WILD-TYPE 192 24

Figure S42.  Get High-res Image Gene #10: 'amp_8q24.21' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_8q24.21' versus 'HISTOLOGICAL_TYPE'

P value = 0.00936 (Fisher's exact test), Q value = 0.06

Table S43.  Gene #10: 'amp_8q24.21' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 10(8Q24.21) MUTATED 228 28 100 5
AMP PEAK 10(8Q24.21) WILD-TYPE 154 32 46 8

Figure S43.  Get High-res Image Gene #10: 'amp_8q24.21' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_11p15.5' versus 'YEARS_TO_BIRTH'

P value = 0.0283 (Wilcoxon-test), Q value = 0.13

Table S44.  Gene #12: 'amp_11p15.5' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
AMP PEAK 12(11P15.5) MUTATED 136 64.3 (12.1)
AMP PEAK 12(11P15.5) WILD-TYPE 474 66.9 (12.9)

Figure S44.  Get High-res Image Gene #12: 'amp_11p15.5' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'amp_11p15.5' versus 'TUMOR_TISSUE_SITE'

P value = 0.0765 (Fisher's exact test), Q value = 0.23

Table S45.  Gene #12: 'amp_11p15.5' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 12(11P15.5) MUTATED 90 44
AMP PEAK 12(11P15.5) WILD-TYPE 356 118

Figure S45.  Get High-res Image Gene #12: 'amp_11p15.5' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_11p15.5' versus 'HISTOLOGICAL_TYPE'

P value = 0.00112 (Fisher's exact test), Q value = 0.012

Table S46.  Gene #12: 'amp_11p15.5' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 12(11P15.5) MUTATED 85 4 43 1
AMP PEAK 12(11P15.5) WILD-TYPE 297 56 103 12

Figure S46.  Get High-res Image Gene #12: 'amp_11p15.5' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_12p13.32' versus 'PATHOLOGY_N_STAGE'

P value = 0.0858 (Fisher's exact test), Q value = 0.25

Table S47.  Gene #13: 'amp_12p13.32' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 13(12P13.32) MUTATED 94 27 29
AMP PEAK 13(12P13.32) WILD-TYPE 251 123 86

Figure S47.  Get High-res Image Gene #13: 'amp_12p13.32' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_13q12.13' versus 'TUMOR_TISSUE_SITE'

P value = 0.000731 (Fisher's exact test), Q value = 0.0085

Table S48.  Gene #14: 'amp_13q12.13' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 14(13Q12.13) MUTATED 272 123
AMP PEAK 14(13Q12.13) WILD-TYPE 174 39

Figure S48.  Get High-res Image Gene #14: 'amp_13q12.13' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_13q12.13' versus 'PATHOLOGIC_STAGE'

P value = 7e-05 (Fisher's exact test), Q value = 0.0013

Table S49.  Gene #14: 'amp_13q12.13' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 14(13Q12.13) MUTATED 64 0 16 100 4 3 16 15 62 38 51 22 0
AMP PEAK 14(13Q12.13) WILD-TYPE 40 1 20 73 6 0 10 3 21 16 12 4 2

Figure S49.  Get High-res Image Gene #14: 'amp_13q12.13' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_13q12.13' versus 'PATHOLOGY_N_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S50.  Gene #14: 'amp_13q12.13' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 14(13Q12.13) MUTATED 197 113 87
AMP PEAK 14(13Q12.13) WILD-TYPE 148 37 28

Figure S50.  Get High-res Image Gene #14: 'amp_13q12.13' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_13q12.13' versus 'PATHOLOGY_M_STAGE'

P value = 0.00212 (Fisher's exact test), Q value = 0.02

Table S51.  Gene #14: 'amp_13q12.13' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 14(13Q12.13) MUTATED 282 70
AMP PEAK 14(13Q12.13) WILD-TYPE 168 18

Figure S51.  Get High-res Image Gene #14: 'amp_13q12.13' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_13q12.13' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S52.  Gene #14: 'amp_13q12.13' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 14(13Q12.13) MUTATED 253 18 117 5
AMP PEAK 14(13Q12.13) WILD-TYPE 129 42 29 8

Figure S52.  Get High-res Image Gene #14: 'amp_13q12.13' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_13q12.13' versus 'RESIDUAL_TUMOR'

P value = 0.0402 (Fisher's exact test), Q value = 0.16

Table S53.  Gene #14: 'amp_13q12.13' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
AMP PEAK 14(13Q12.13) MUTATED 283 3 29 13
AMP PEAK 14(13Q12.13) WILD-TYPE 159 2 8 16

Figure S53.  Get High-res Image Gene #14: 'amp_13q12.13' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'amp_13q12.13' versus 'NUMBER_OF_LYMPH_NODES'

P value = 4.28e-05 (Wilcoxon-test), Q value = 0.00097

Table S54.  Gene #14: 'amp_13q12.13' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 14(13Q12.13) MUTATED 379 2.6 (4.9)
AMP PEAK 14(13Q12.13) WILD-TYPE 197 1.6 (4.2)

Figure S54.  Get High-res Image Gene #14: 'amp_13q12.13' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_13q12.13' versus 'RACE'

P value = 0.0215 (Fisher's exact test), Q value = 0.11

Table S55.  Gene #14: 'amp_13q12.13' versus Clinical Feature #13: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN WHITE
ALL 1 12 64 292
AMP PEAK 14(13Q12.13) MUTATED 0 4 42 204
AMP PEAK 14(13Q12.13) WILD-TYPE 1 8 22 88

Figure S55.  Get High-res Image Gene #14: 'amp_13q12.13' versus Clinical Feature #13: 'RACE'

'amp_13q12.2' versus 'TUMOR_TISSUE_SITE'

P value = 0.000553 (Fisher's exact test), Q value = 0.0067

Table S56.  Gene #15: 'amp_13q12.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 15(13Q12.2) MUTATED 268 122
AMP PEAK 15(13Q12.2) WILD-TYPE 178 40

Figure S56.  Get High-res Image Gene #15: 'amp_13q12.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_13q12.2' versus 'PATHOLOGIC_STAGE'

P value = 1e-04 (Fisher's exact test), Q value = 0.0017

Table S57.  Gene #15: 'amp_13q12.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 15(13Q12.2) MUTATED 64 0 16 98 4 3 16 15 62 37 50 21 0
AMP PEAK 15(13Q12.2) WILD-TYPE 40 1 20 75 6 0 10 3 21 17 13 5 2

Figure S57.  Get High-res Image Gene #15: 'amp_13q12.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_13q12.2' versus 'PATHOLOGY_N_STAGE'

P value = 6e-05 (Fisher's exact test), Q value = 0.0012

Table S58.  Gene #15: 'amp_13q12.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 15(13Q12.2) MUTATED 195 111 86
AMP PEAK 15(13Q12.2) WILD-TYPE 150 39 29

Figure S58.  Get High-res Image Gene #15: 'amp_13q12.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_13q12.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.00711 (Fisher's exact test), Q value = 0.049

Table S59.  Gene #15: 'amp_13q12.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 15(13Q12.2) MUTATED 279 68
AMP PEAK 15(13Q12.2) WILD-TYPE 171 20

Figure S59.  Get High-res Image Gene #15: 'amp_13q12.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_13q12.2' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S60.  Gene #15: 'amp_13q12.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 15(13Q12.2) MUTATED 249 18 116 5
AMP PEAK 15(13Q12.2) WILD-TYPE 133 42 30 8

Figure S60.  Get High-res Image Gene #15: 'amp_13q12.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_13q12.2' versus 'RESIDUAL_TUMOR'

P value = 0.0712 (Fisher's exact test), Q value = 0.22

Table S61.  Gene #15: 'amp_13q12.2' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
AMP PEAK 15(13Q12.2) MUTATED 280 3 28 13
AMP PEAK 15(13Q12.2) WILD-TYPE 162 2 9 16

Figure S61.  Get High-res Image Gene #15: 'amp_13q12.2' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'amp_13q12.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 5.39e-05 (Wilcoxon-test), Q value = 0.0011

Table S62.  Gene #15: 'amp_13q12.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 15(13Q12.2) MUTATED 375 2.6 (4.9)
AMP PEAK 15(13Q12.2) WILD-TYPE 201 1.6 (4.2)

Figure S62.  Get High-res Image Gene #15: 'amp_13q12.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_13q12.2' versus 'RACE'

P value = 0.0271 (Fisher's exact test), Q value = 0.12

Table S63.  Gene #15: 'amp_13q12.2' versus Clinical Feature #13: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN WHITE
ALL 1 12 64 292
AMP PEAK 15(13Q12.2) MUTATED 0 4 42 201
AMP PEAK 15(13Q12.2) WILD-TYPE 1 8 22 91

Figure S63.  Get High-res Image Gene #15: 'amp_13q12.2' versus Clinical Feature #13: 'RACE'

'amp_13q22.1' versus 'TUMOR_TISSUE_SITE'

P value = 0.0167 (Fisher's exact test), Q value = 0.087

Table S64.  Gene #16: 'amp_13q22.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 16(13Q22.1) MUTATED 275 117
AMP PEAK 16(13Q22.1) WILD-TYPE 171 45

Figure S64.  Get High-res Image Gene #16: 'amp_13q22.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_13q22.1' versus 'PATHOLOGIC_STAGE'

P value = 0.00092 (Fisher's exact test), Q value = 0.01

Table S65.  Gene #16: 'amp_13q22.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 16(13Q22.1) MUTATED 65 0 20 94 4 3 17 15 60 40 49 20 0
AMP PEAK 16(13Q22.1) WILD-TYPE 39 1 16 79 6 0 9 3 23 14 14 6 2

Figure S65.  Get High-res Image Gene #16: 'amp_13q22.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_13q22.1' versus 'PATHOLOGY_N_STAGE'

P value = 3e-05 (Fisher's exact test), Q value = 0.00075

Table S66.  Gene #16: 'amp_13q22.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 16(13Q22.1) MUTATED 196 113 85
AMP PEAK 16(13Q22.1) WILD-TYPE 149 37 30

Figure S66.  Get High-res Image Gene #16: 'amp_13q22.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_13q22.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.0108 (Fisher's exact test), Q value = 0.066

Table S67.  Gene #16: 'amp_13q22.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 16(13Q22.1) MUTATED 279 67
AMP PEAK 16(13Q22.1) WILD-TYPE 171 21

Figure S67.  Get High-res Image Gene #16: 'amp_13q22.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_13q22.1' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S68.  Gene #16: 'amp_13q22.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 16(13Q22.1) MUTATED 254 19 112 4
AMP PEAK 16(13Q22.1) WILD-TYPE 128 41 34 9

Figure S68.  Get High-res Image Gene #16: 'amp_13q22.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_13q22.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000254 (Wilcoxon-test), Q value = 0.0039

Table S69.  Gene #16: 'amp_13q22.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 16(13Q22.1) MUTATED 379 2.5 (4.7)
AMP PEAK 16(13Q22.1) WILD-TYPE 197 1.8 (4.7)

Figure S69.  Get High-res Image Gene #16: 'amp_13q22.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_15q26.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.0027 (Fisher's exact test), Q value = 0.024

Table S70.  Gene #17: 'amp_15q26.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 17(15Q26.1) MUTATED 17 8 17
AMP PEAK 17(15Q26.1) WILD-TYPE 328 142 98

Figure S70.  Get High-res Image Gene #17: 'amp_15q26.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_15q26.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0039 (Wilcoxon-test), Q value = 0.032

Table S71.  Gene #17: 'amp_15q26.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 17(15Q26.1) MUTATED 39 4.1 (6.3)
AMP PEAK 17(15Q26.1) WILD-TYPE 537 2.1 (4.6)

Figure S71.  Get High-res Image Gene #17: 'amp_15q26.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_16p11.2' versus 'PATHOLOGIC_STAGE'

P value = 0.00175 (Fisher's exact test), Q value = 0.017

Table S72.  Gene #18: 'amp_16p11.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 18(16P11.2) MUTATED 20 1 4 39 3 0 7 9 31 21 23 8 1
AMP PEAK 18(16P11.2) WILD-TYPE 84 0 32 134 7 3 19 9 52 33 40 18 1

Figure S72.  Get High-res Image Gene #18: 'amp_16p11.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_16p11.2' versus 'PATHOLOGY_N_STAGE'

P value = 1e-04 (Fisher's exact test), Q value = 0.0017

Table S73.  Gene #18: 'amp_16p11.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 18(16P11.2) MUTATED 73 55 43
AMP PEAK 18(16P11.2) WILD-TYPE 272 95 72

Figure S73.  Get High-res Image Gene #18: 'amp_16p11.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_16p11.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.05 (Fisher's exact test), Q value = 0.18

Table S74.  Gene #18: 'amp_16p11.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 18(16P11.2) MUTATED 116 32
AMP PEAK 18(16P11.2) WILD-TYPE 334 56

Figure S74.  Get High-res Image Gene #18: 'amp_16p11.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_16p11.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.00055 (Fisher's exact test), Q value = 0.0067

Table S75.  Gene #18: 'amp_16p11.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 18(16P11.2) MUTATED 115 7 47 0
AMP PEAK 18(16P11.2) WILD-TYPE 267 53 99 13

Figure S75.  Get High-res Image Gene #18: 'amp_16p11.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_16p11.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 7.42e-05 (Wilcoxon-test), Q value = 0.0014

Table S76.  Gene #18: 'amp_16p11.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 18(16P11.2) MUTATED 163 3.1 (5.9)
AMP PEAK 18(16P11.2) WILD-TYPE 413 1.9 (4.1)

Figure S76.  Get High-res Image Gene #18: 'amp_16p11.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_17q12' versus 'Time to Death'

P value = 0.0718 (logrank test), Q value = 0.22

Table S77.  Gene #19: 'amp_17q12' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
AMP PEAK 19(17Q12) MUTATED 153 22 0.0 - 148.0 (20.0)
AMP PEAK 19(17Q12) WILD-TYPE 440 99 0.0 - 140.4 (20.0)

Figure S77.  Get High-res Image Gene #19: 'amp_17q12' versus Clinical Feature #1: 'Time to Death'

'amp_17q12' versus 'PATHOLOGY_M_STAGE'

P value = 0.00305 (Fisher's exact test), Q value = 0.026

Table S78.  Gene #19: 'amp_17q12' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 19(17Q12) MUTATED 103 34
AMP PEAK 19(17Q12) WILD-TYPE 347 54

Figure S78.  Get High-res Image Gene #19: 'amp_17q12' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_17q12' versus 'RESIDUAL_TUMOR'

P value = 0.0695 (Fisher's exact test), Q value = 0.22

Table S79.  Gene #19: 'amp_17q12' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
AMP PEAK 19(17Q12) MUTATED 110 2 16 6
AMP PEAK 19(17Q12) WILD-TYPE 332 3 21 23

Figure S79.  Get High-res Image Gene #19: 'amp_17q12' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'amp_17q24.1' versus 'Time to Death'

P value = 0.00967 (logrank test), Q value = 0.06

Table S80.  Gene #20: 'amp_17q24.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
AMP PEAK 20(17Q24.1) MUTATED 139 17 0.1 - 148.0 (22.0)
AMP PEAK 20(17Q24.1) WILD-TYPE 454 104 0.0 - 140.4 (20.0)

Figure S80.  Get High-res Image Gene #20: 'amp_17q24.1' versus Clinical Feature #1: 'Time to Death'

'amp_17q24.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.0704 (Fisher's exact test), Q value = 0.22

Table S81.  Gene #20: 'amp_17q24.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 20(17Q24.1) MUTATED 96 27
AMP PEAK 20(17Q24.1) WILD-TYPE 354 61

Figure S81.  Get High-res Image Gene #20: 'amp_17q24.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_17q24.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0815 (Fisher's exact test), Q value = 0.24

Table S82.  Gene #20: 'amp_17q24.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 20(17Q24.1) MUTATED 94 10 38 0
AMP PEAK 20(17Q24.1) WILD-TYPE 288 50 108 13

Figure S82.  Get High-res Image Gene #20: 'amp_17q24.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_19p13.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0496 (Fisher's exact test), Q value = 0.18

Table S83.  Gene #21: 'amp_19p13.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 21(19P13.2) MUTATED 67 8 36 0
AMP PEAK 21(19P13.2) WILD-TYPE 315 52 110 13

Figure S83.  Get High-res Image Gene #21: 'amp_19p13.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_19q12' versus 'PATHOLOGY_M_STAGE'

P value = 0.0169 (Fisher's exact test), Q value = 0.088

Table S84.  Gene #22: 'amp_19q12' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 22(19Q12) MUTATED 90 28
AMP PEAK 22(19Q12) WILD-TYPE 360 60

Figure S84.  Get High-res Image Gene #22: 'amp_19q12' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_19q12' versus 'HISTOLOGICAL_TYPE'

P value = 0.0202 (Fisher's exact test), Q value = 0.1

Table S85.  Gene #22: 'amp_19q12' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 22(19Q12) MUTATED 85 10 44 0
AMP PEAK 22(19Q12) WILD-TYPE 297 50 102 13

Figure S85.  Get High-res Image Gene #22: 'amp_19q12' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_20p12.1' versus 'PATHOLOGIC_STAGE'

P value = 0.0133 (Fisher's exact test), Q value = 0.075

Table S86.  Gene #23: 'amp_20p12.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 23(20P12.1) MUTATED 50 1 10 69 4 1 10 11 33 24 42 13 1
AMP PEAK 23(20P12.1) WILD-TYPE 54 0 26 104 6 2 16 7 50 30 21 13 1

Figure S86.  Get High-res Image Gene #23: 'amp_20p12.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_20p12.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.000643 (Fisher's exact test), Q value = 0.0076

Table S87.  Gene #23: 'amp_20p12.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 23(20P12.1) MUTATED 186 54
AMP PEAK 23(20P12.1) WILD-TYPE 264 34

Figure S87.  Get High-res Image Gene #23: 'amp_20p12.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_20p12.1' versus 'GENDER'

P value = 0.0344 (Fisher's exact test), Q value = 0.14

Table S88.  Gene #23: 'amp_20p12.1' versus Clinical Feature #8: 'GENDER'

nPatients FEMALE MALE
ALL 287 325
AMP PEAK 23(20P12.1) MUTATED 117 161
AMP PEAK 23(20P12.1) WILD-TYPE 170 164

Figure S88.  Get High-res Image Gene #23: 'amp_20p12.1' versus Clinical Feature #8: 'GENDER'

'amp_20p12.1' versus 'RADIATION_THERAPY'

P value = 0.05 (Fisher's exact test), Q value = 0.18

Table S89.  Gene #23: 'amp_20p12.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
AMP PEAK 23(20P12.1) MUTATED 198 18
AMP PEAK 23(20P12.1) WILD-TYPE 248 10

Figure S89.  Get High-res Image Gene #23: 'amp_20p12.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

'amp_20p12.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0111 (Fisher's exact test), Q value = 0.067

Table S90.  Gene #23: 'amp_20p12.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 23(20P12.1) MUTATED 175 18 76 3
AMP PEAK 23(20P12.1) WILD-TYPE 207 42 70 10

Figure S90.  Get High-res Image Gene #23: 'amp_20p12.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_20p11.21' versus 'TUMOR_TISSUE_SITE'

P value = 0.009 (Fisher's exact test), Q value = 0.058

Table S91.  Gene #24: 'amp_20p11.21' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 24(20P11.21) MUTATED 250 110
AMP PEAK 24(20P11.21) WILD-TYPE 196 52

Figure S91.  Get High-res Image Gene #24: 'amp_20p11.21' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_20p11.21' versus 'PATHOLOGIC_STAGE'

P value = 0.0215 (Fisher's exact test), Q value = 0.11

Table S92.  Gene #24: 'amp_20p11.21' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 24(20P11.21) MUTATED 64 1 16 97 5 2 11 15 45 30 48 17 1
AMP PEAK 24(20P11.21) WILD-TYPE 40 0 20 76 5 1 15 3 38 24 15 9 1

Figure S92.  Get High-res Image Gene #24: 'amp_20p11.21' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_20p11.21' versus 'PATHOLOGY_M_STAGE'

P value = 0.00136 (Fisher's exact test), Q value = 0.014

Table S93.  Gene #24: 'amp_20p11.21' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 24(20P11.21) MUTATED 250 65
AMP PEAK 24(20P11.21) WILD-TYPE 200 23

Figure S93.  Get High-res Image Gene #24: 'amp_20p11.21' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_20p11.21' versus 'GENDER'

P value = 0.0582 (Fisher's exact test), Q value = 0.2

Table S94.  Gene #24: 'amp_20p11.21' versus Clinical Feature #8: 'GENDER'

nPatients FEMALE MALE
ALL 287 325
AMP PEAK 24(20P11.21) MUTATED 158 204
AMP PEAK 24(20P11.21) WILD-TYPE 129 121

Figure S94.  Get High-res Image Gene #24: 'amp_20p11.21' versus Clinical Feature #8: 'GENDER'

'amp_20p11.21' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S95.  Gene #24: 'amp_20p11.21' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 24(20P11.21) MUTATED 227 22 105 4
AMP PEAK 24(20P11.21) WILD-TYPE 155 38 41 9

Figure S95.  Get High-res Image Gene #24: 'amp_20p11.21' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_20q11.21' versus 'TUMOR_TISSUE_SITE'

P value = 4.86e-06 (Fisher's exact test), Q value = 0.00032

Table S96.  Gene #25: 'amp_20q11.21' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 25(20Q11.21) MUTATED 319 144
AMP PEAK 25(20Q11.21) WILD-TYPE 127 18

Figure S96.  Get High-res Image Gene #25: 'amp_20q11.21' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_20q11.21' versus 'PATHOLOGIC_STAGE'

P value = 0.00275 (Fisher's exact test), Q value = 0.024

Table S97.  Gene #25: 'amp_20q11.21' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 25(20Q11.21) MUTATED 79 1 21 119 5 3 20 17 67 44 56 22 1
AMP PEAK 25(20Q11.21) WILD-TYPE 25 0 15 54 5 0 6 1 16 10 7 4 1

Figure S97.  Get High-res Image Gene #25: 'amp_20q11.21' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_20q11.21' versus 'PATHOLOGY_N_STAGE'

P value = 0.00088 (Fisher's exact test), Q value = 0.01

Table S98.  Gene #25: 'amp_20q11.21' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 25(20Q11.21) MUTATED 243 128 93
AMP PEAK 25(20Q11.21) WILD-TYPE 102 22 22

Figure S98.  Get High-res Image Gene #25: 'amp_20q11.21' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_20q11.21' versus 'PATHOLOGY_M_STAGE'

P value = 0.00596 (Fisher's exact test), Q value = 0.043

Table S99.  Gene #25: 'amp_20q11.21' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 25(20Q11.21) MUTATED 333 77
AMP PEAK 25(20Q11.21) WILD-TYPE 117 11

Figure S99.  Get High-res Image Gene #25: 'amp_20q11.21' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_20q11.21' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S100.  Gene #25: 'amp_20q11.21' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 25(20Q11.21) MUTATED 291 25 135 7
AMP PEAK 25(20Q11.21) WILD-TYPE 91 35 11 6

Figure S100.  Get High-res Image Gene #25: 'amp_20q11.21' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_20q11.21' versus 'RESIDUAL_TUMOR'

P value = 0.0702 (Fisher's exact test), Q value = 0.22

Table S101.  Gene #25: 'amp_20q11.21' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
AMP PEAK 25(20Q11.21) MUTATED 335 4 32 17
AMP PEAK 25(20Q11.21) WILD-TYPE 107 1 5 12

Figure S101.  Get High-res Image Gene #25: 'amp_20q11.21' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'amp_20q11.21' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00482 (Wilcoxon-test), Q value = 0.037

Table S102.  Gene #25: 'amp_20q11.21' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 25(20Q11.21) MUTATED 443 2.3 (4.7)
AMP PEAK 25(20Q11.21) WILD-TYPE 133 1.9 (4.9)

Figure S102.  Get High-res Image Gene #25: 'amp_20q11.21' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_20q12' versus 'TUMOR_TISSUE_SITE'

P value = 2.51e-06 (Fisher's exact test), Q value = 0.00032

Table S103.  Gene #26: 'amp_20q12' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 26(20Q12) MUTATED 320 145
AMP PEAK 26(20Q12) WILD-TYPE 126 17

Figure S103.  Get High-res Image Gene #26: 'amp_20q12' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_20q12' versus 'PATHOLOGIC_STAGE'

P value = 0.00097 (Fisher's exact test), Q value = 0.01

Table S104.  Gene #26: 'amp_20q12' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 26(20Q12) MUTATED 79 1 21 120 5 3 19 17 67 44 56 24 1
AMP PEAK 26(20Q12) WILD-TYPE 25 0 15 53 5 0 7 1 16 10 7 2 1

Figure S104.  Get High-res Image Gene #26: 'amp_20q12' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_20q12' versus 'PATHOLOGY_N_STAGE'

P value = 0.00038 (Fisher's exact test), Q value = 0.0054

Table S105.  Gene #26: 'amp_20q12' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 26(20Q12) MUTATED 244 129 93
AMP PEAK 26(20Q12) WILD-TYPE 101 21 22

Figure S105.  Get High-res Image Gene #26: 'amp_20q12' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_20q12' versus 'PATHOLOGY_M_STAGE'

P value = 0.000893 (Fisher's exact test), Q value = 0.01

Table S106.  Gene #26: 'amp_20q12' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 26(20Q12) MUTATED 333 79
AMP PEAK 26(20Q12) WILD-TYPE 117 9

Figure S106.  Get High-res Image Gene #26: 'amp_20q12' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_20q12' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S107.  Gene #26: 'amp_20q12' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 26(20Q12) MUTATED 293 24 136 7
AMP PEAK 26(20Q12) WILD-TYPE 89 36 10 6

Figure S107.  Get High-res Image Gene #26: 'amp_20q12' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_20q12' versus 'RESIDUAL_TUMOR'

P value = 0.0699 (Fisher's exact test), Q value = 0.22

Table S108.  Gene #26: 'amp_20q12' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
AMP PEAK 26(20Q12) MUTATED 336 4 32 17
AMP PEAK 26(20Q12) WILD-TYPE 106 1 5 12

Figure S108.  Get High-res Image Gene #26: 'amp_20q12' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'amp_20q12' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00503 (Wilcoxon-test), Q value = 0.038

Table S109.  Gene #26: 'amp_20q12' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 26(20Q12) MUTATED 443 2.3 (4.7)
AMP PEAK 26(20Q12) WILD-TYPE 133 1.9 (4.9)

Figure S109.  Get High-res Image Gene #26: 'amp_20q12' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'amp_20q13.31' versus 'TUMOR_TISSUE_SITE'

P value = 2.52e-06 (Fisher's exact test), Q value = 0.00032

Table S110.  Gene #27: 'amp_20q13.31' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
AMP PEAK 27(20Q13.31) MUTATED 321 145
AMP PEAK 27(20Q13.31) WILD-TYPE 125 17

Figure S110.  Get High-res Image Gene #27: 'amp_20q13.31' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'amp_20q13.31' versus 'PATHOLOGIC_STAGE'

P value = 0.0014 (Fisher's exact test), Q value = 0.014

Table S111.  Gene #27: 'amp_20q13.31' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
AMP PEAK 27(20Q13.31) MUTATED 79 1 22 120 5 3 20 17 67 45 57 23 1
AMP PEAK 27(20Q13.31) WILD-TYPE 25 0 14 53 5 0 6 1 16 9 6 3 1

Figure S111.  Get High-res Image Gene #27: 'amp_20q13.31' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'amp_20q13.31' versus 'PATHOLOGY_N_STAGE'

P value = 0.00049 (Fisher's exact test), Q value = 0.0063

Table S112.  Gene #27: 'amp_20q13.31' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
AMP PEAK 27(20Q13.31) MUTATED 245 129 94
AMP PEAK 27(20Q13.31) WILD-TYPE 100 21 21

Figure S112.  Get High-res Image Gene #27: 'amp_20q13.31' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'amp_20q13.31' versus 'PATHOLOGY_M_STAGE'

P value = 0.00135 (Fisher's exact test), Q value = 0.014

Table S113.  Gene #27: 'amp_20q13.31' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
AMP PEAK 27(20Q13.31) MUTATED 336 79
AMP PEAK 27(20Q13.31) WILD-TYPE 114 9

Figure S113.  Get High-res Image Gene #27: 'amp_20q13.31' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'amp_20q13.31' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S114.  Gene #27: 'amp_20q13.31' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
AMP PEAK 27(20Q13.31) MUTATED 293 25 136 7
AMP PEAK 27(20Q13.31) WILD-TYPE 89 35 10 6

Figure S114.  Get High-res Image Gene #27: 'amp_20q13.31' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'amp_20q13.31' versus 'RESIDUAL_TUMOR'

P value = 0.0675 (Fisher's exact test), Q value = 0.22

Table S115.  Gene #27: 'amp_20q13.31' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
AMP PEAK 27(20Q13.31) MUTATED 338 4 32 17
AMP PEAK 27(20Q13.31) WILD-TYPE 104 1 5 12

Figure S115.  Get High-res Image Gene #27: 'amp_20q13.31' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'amp_20q13.31' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00461 (Wilcoxon-test), Q value = 0.036

Table S116.  Gene #27: 'amp_20q13.31' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
AMP PEAK 27(20Q13.31) MUTATED 446 2.3 (4.7)
AMP PEAK 27(20Q13.31) WILD-TYPE 130 1.9 (4.9)

Figure S116.  Get High-res Image Gene #27: 'amp_20q13.31' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_1p36.11' versus 'YEARS_TO_BIRTH'

P value = 0.0677 (Wilcoxon-test), Q value = 0.22

Table S117.  Gene #28: 'del_1p36.11' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
DEL PEAK 1(1P36.11) MUTATED 242 65.4 (11.8)
DEL PEAK 1(1P36.11) WILD-TYPE 368 66.9 (13.4)

Figure S117.  Get High-res Image Gene #28: 'del_1p36.11' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_1p36.11' versus 'PATHOLOGIC_STAGE'

P value = 0.00344 (Fisher's exact test), Q value = 0.029

Table S118.  Gene #28: 'del_1p36.11' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 1(1P36.11) MUTATED 33 0 8 63 3 1 10 7 31 25 38 16 0
DEL PEAK 1(1P36.11) WILD-TYPE 71 1 28 110 7 2 16 11 52 29 25 10 2

Figure S118.  Get High-res Image Gene #28: 'del_1p36.11' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_1p36.11' versus 'PATHOLOGY_N_STAGE'

P value = 0.00392 (Fisher's exact test), Q value = 0.032

Table S119.  Gene #28: 'del_1p36.11' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 1(1P36.11) MUTATED 117 65 58
DEL PEAK 1(1P36.11) WILD-TYPE 228 85 57

Figure S119.  Get High-res Image Gene #28: 'del_1p36.11' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_1p36.11' versus 'PATHOLOGY_M_STAGE'

P value = 4.26e-05 (Fisher's exact test), Q value = 0.00097

Table S120.  Gene #28: 'del_1p36.11' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 1(1P36.11) MUTATED 162 53
DEL PEAK 1(1P36.11) WILD-TYPE 288 35

Figure S120.  Get High-res Image Gene #28: 'del_1p36.11' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_1p36.11' versus 'HISTOLOGICAL_TYPE'

P value = 0.00168 (Fisher's exact test), Q value = 0.017

Table S121.  Gene #28: 'del_1p36.11' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 1(1P36.11) MUTATED 154 11 65 7
DEL PEAK 1(1P36.11) WILD-TYPE 228 49 81 6

Figure S121.  Get High-res Image Gene #28: 'del_1p36.11' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_1p36.11' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000507 (Wilcoxon-test), Q value = 0.0065

Table S122.  Gene #28: 'del_1p36.11' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 1(1P36.11) MUTATED 226 3.1 (6.0)
DEL PEAK 1(1P36.11) WILD-TYPE 350 1.7 (3.5)

Figure S122.  Get High-res Image Gene #28: 'del_1p36.11' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_1p33' versus 'Time to Death'

P value = 0.0268 (logrank test), Q value = 0.12

Table S123.  Gene #29: 'del_1p33' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 2(1P33) MUTATED 169 43 0.0 - 129.3 (20.0)
DEL PEAK 2(1P33) WILD-TYPE 424 78 0.0 - 148.0 (20.0)

Figure S123.  Get High-res Image Gene #29: 'del_1p33' versus Clinical Feature #1: 'Time to Death'

'del_1p33' versus 'PATHOLOGIC_STAGE'

P value = 0.0329 (Fisher's exact test), Q value = 0.14

Table S124.  Gene #29: 'del_1p33' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 2(1P33) MUTATED 19 0 7 50 1 0 7 5 25 20 29 6 0
DEL PEAK 2(1P33) WILD-TYPE 85 1 29 123 9 3 19 13 58 34 34 20 2

Figure S124.  Get High-res Image Gene #29: 'del_1p33' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_1p33' versus 'PATHOLOGY_N_STAGE'

P value = 0.0318 (Fisher's exact test), Q value = 0.14

Table S125.  Gene #29: 'del_1p33' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 2(1P33) MUTATED 84 51 39
DEL PEAK 2(1P33) WILD-TYPE 261 99 76

Figure S125.  Get High-res Image Gene #29: 'del_1p33' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_1p33' versus 'PATHOLOGY_M_STAGE'

P value = 0.0137 (Fisher's exact test), Q value = 0.076

Table S126.  Gene #29: 'del_1p33' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 2(1P33) MUTATED 118 35
DEL PEAK 2(1P33) WILD-TYPE 332 53

Figure S126.  Get High-res Image Gene #29: 'del_1p33' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_1p33' versus 'HISTOLOGICAL_TYPE'

P value = 0.0142 (Fisher's exact test), Q value = 0.078

Table S127.  Gene #29: 'del_1p33' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 2(1P33) MUTATED 112 9 49 1
DEL PEAK 2(1P33) WILD-TYPE 270 51 97 12

Figure S127.  Get High-res Image Gene #29: 'del_1p33' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_1p33' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00714 (Wilcoxon-test), Q value = 0.049

Table S128.  Gene #29: 'del_1p33' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 2(1P33) MUTATED 163 3.1 (6.1)
DEL PEAK 2(1P33) WILD-TYPE 413 1.9 (4.0)

Figure S128.  Get High-res Image Gene #29: 'del_1p33' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_1p13.2' versus 'Time to Death'

P value = 0.0262 (logrank test), Q value = 0.12

Table S129.  Gene #30: 'del_1p13.2' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 3(1P13.2) MUTATED 169 42 0.2 - 131.5 (18.2)
DEL PEAK 3(1P13.2) WILD-TYPE 424 79 0.0 - 148.0 (20.4)

Figure S129.  Get High-res Image Gene #30: 'del_1p13.2' versus Clinical Feature #1: 'Time to Death'

'del_1p13.2' versus 'PATHOLOGIC_STAGE'

P value = 0.00774 (Fisher's exact test), Q value = 0.052

Table S130.  Gene #30: 'del_1p13.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 3(1P13.2) MUTATED 19 0 8 48 1 2 5 4 24 21 30 6 0
DEL PEAK 3(1P13.2) WILD-TYPE 85 1 28 125 9 1 21 14 59 33 33 20 2

Figure S130.  Get High-res Image Gene #30: 'del_1p13.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_1p13.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.0114 (Fisher's exact test), Q value = 0.068

Table S131.  Gene #30: 'del_1p13.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 3(1P13.2) MUTATED 83 46 44
DEL PEAK 3(1P13.2) WILD-TYPE 262 104 71

Figure S131.  Get High-res Image Gene #30: 'del_1p13.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_1p13.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.00965 (Fisher's exact test), Q value = 0.06

Table S132.  Gene #30: 'del_1p13.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 3(1P13.2) MUTATED 119 36
DEL PEAK 3(1P13.2) WILD-TYPE 331 52

Figure S132.  Get High-res Image Gene #30: 'del_1p13.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_1p13.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0705 (Fisher's exact test), Q value = 0.22

Table S133.  Gene #30: 'del_1p13.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 3(1P13.2) MUTATED 110 10 49 2
DEL PEAK 3(1P13.2) WILD-TYPE 272 50 97 11

Figure S133.  Get High-res Image Gene #30: 'del_1p13.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_1p13.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000694 (Wilcoxon-test), Q value = 0.0081

Table S134.  Gene #30: 'del_1p13.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 3(1P13.2) MUTATED 162 3.2 (5.3)
DEL PEAK 3(1P13.2) WILD-TYPE 414 1.9 (4.4)

Figure S134.  Get High-res Image Gene #30: 'del_1p13.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_2p12' versus 'TUMOR_TISSUE_SITE'

P value = 0.000581 (Fisher's exact test), Q value = 0.007

Table S135.  Gene #31: 'del_2p12' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 4(2P12) MUTATED 8 13
DEL PEAK 4(2P12) WILD-TYPE 438 149

Figure S135.  Get High-res Image Gene #31: 'del_2p12' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_2p12' versus 'RADIATION_THERAPY'

P value = 0.0829 (Fisher's exact test), Q value = 0.24

Table S136.  Gene #31: 'del_2p12' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 4(2P12) MUTATED 15 3
DEL PEAK 4(2P12) WILD-TYPE 431 25

Figure S136.  Get High-res Image Gene #31: 'del_2p12' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_2p12' versus 'HISTOLOGICAL_TYPE'

P value = 0.00645 (Fisher's exact test), Q value = 0.046

Table S137.  Gene #31: 'del_2p12' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 4(2P12) MUTATED 8 0 11 1
DEL PEAK 4(2P12) WILD-TYPE 374 60 135 12

Figure S137.  Get High-res Image Gene #31: 'del_2p12' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_2q22.1' versus 'RACE'

P value = 0.0114 (Fisher's exact test), Q value = 0.068

Table S138.  Gene #32: 'del_2q22.1' versus Clinical Feature #13: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN WHITE
ALL 1 12 64 292
DEL PEAK 5(2Q22.1) MUTATED 1 2 2 12
DEL PEAK 5(2Q22.1) WILD-TYPE 0 10 62 280

Figure S138.  Get High-res Image Gene #32: 'del_2q22.1' versus Clinical Feature #13: 'RACE'

'del_3p26.3' versus 'Time to Death'

P value = 0.0151 (logrank test), Q value = 0.081

Table S139.  Gene #33: 'del_3p26.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 6(3P26.3) MUTATED 90 21 0.4 - 85.0 (15.1)
DEL PEAK 6(3P26.3) WILD-TYPE 503 100 0.0 - 148.0 (21.0)

Figure S139.  Get High-res Image Gene #33: 'del_3p26.3' versus Clinical Feature #1: 'Time to Death'

'del_3p26.3' versus 'PATHOLOGIC_STAGE'

P value = 0.0253 (Fisher's exact test), Q value = 0.12

Table S140.  Gene #33: 'del_3p26.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 6(3P26.3) MUTATED 8 0 3 25 0 1 5 2 14 8 20 5 0
DEL PEAK 6(3P26.3) WILD-TYPE 96 1 33 148 10 2 21 16 69 46 43 21 2

Figure S140.  Get High-res Image Gene #33: 'del_3p26.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_3p26.3' versus 'PATHOLOGY_T_STAGE'

P value = 0.0783 (Fisher's exact test), Q value = 0.23

Table S141.  Gene #33: 'del_3p26.3' versus Clinical Feature #5: 'PATHOLOGY_T_STAGE'

nPatients T1 T2 T3 T4
ALL 20 106 417 67
DEL PEAK 6(3P26.3) MUTATED 2 8 71 11
DEL PEAK 6(3P26.3) WILD-TYPE 18 98 346 56

Figure S141.  Get High-res Image Gene #33: 'del_3p26.3' versus Clinical Feature #5: 'PATHOLOGY_T_STAGE'

'del_3p26.3' versus 'PATHOLOGY_N_STAGE'

P value = 0.0189 (Fisher's exact test), Q value = 0.095

Table S142.  Gene #33: 'del_3p26.3' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 6(3P26.3) MUTATED 40 28 24
DEL PEAK 6(3P26.3) WILD-TYPE 305 122 91

Figure S142.  Get High-res Image Gene #33: 'del_3p26.3' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_3p26.3' versus 'PATHOLOGY_M_STAGE'

P value = 0.000468 (Fisher's exact test), Q value = 0.0061

Table S143.  Gene #33: 'del_3p26.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 6(3P26.3) MUTATED 56 25
DEL PEAK 6(3P26.3) WILD-TYPE 394 63

Figure S143.  Get High-res Image Gene #33: 'del_3p26.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_3p26.3' versus 'HISTOLOGICAL_TYPE'

P value = 0.0469 (Fisher's exact test), Q value = 0.17

Table S144.  Gene #33: 'del_3p26.3' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 6(3P26.3) MUTATED 66 4 16 3
DEL PEAK 6(3P26.3) WILD-TYPE 316 56 130 10

Figure S144.  Get High-res Image Gene #33: 'del_3p26.3' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_3p26.3' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00759 (Wilcoxon-test), Q value = 0.051

Table S145.  Gene #33: 'del_3p26.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 6(3P26.3) MUTATED 85 3.5 (6.3)
DEL PEAK 6(3P26.3) WILD-TYPE 491 2.0 (4.4)

Figure S145.  Get High-res Image Gene #33: 'del_3p26.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_3p14.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.0172 (Fisher's exact test), Q value = 0.089

Table S146.  Gene #34: 'del_3p14.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 7(3P14.2) MUTATED 77 25
DEL PEAK 7(3P14.2) WILD-TYPE 373 63

Figure S146.  Get High-res Image Gene #34: 'del_3p14.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_3q26.31' versus 'PATHOLOGIC_STAGE'

P value = 0.0364 (Fisher's exact test), Q value = 0.15

Table S147.  Gene #35: 'del_3q26.31' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 8(3Q26.31) MUTATED 5 0 1 22 0 1 3 0 6 9 12 4 0
DEL PEAK 8(3Q26.31) WILD-TYPE 99 1 35 151 10 2 23 18 77 45 51 22 2

Figure S147.  Get High-res Image Gene #35: 'del_3q26.31' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_3q26.31' versus 'PATHOLOGY_M_STAGE'

P value = 0.0378 (Fisher's exact test), Q value = 0.15

Table S148.  Gene #35: 'del_3q26.31' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 8(3Q26.31) MUTATED 42 15
DEL PEAK 8(3Q26.31) WILD-TYPE 408 73

Figure S148.  Get High-res Image Gene #35: 'del_3q26.31' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_3q26.31' versus 'HISTOLOGICAL_TYPE'

P value = 0.00945 (Fisher's exact test), Q value = 0.06

Table S149.  Gene #35: 'del_3q26.31' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 8(3Q26.31) MUTATED 42 3 11 5
DEL PEAK 8(3Q26.31) WILD-TYPE 340 57 135 8

Figure S149.  Get High-res Image Gene #35: 'del_3q26.31' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_4p16.2' versus 'TUMOR_TISSUE_SITE'

P value = 0.0774 (Fisher's exact test), Q value = 0.23

Table S150.  Gene #36: 'del_4p16.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 9(4P16.2) MUTATED 135 62
DEL PEAK 9(4P16.2) WILD-TYPE 311 100

Figure S150.  Get High-res Image Gene #36: 'del_4p16.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_4p16.2' versus 'PATHOLOGIC_STAGE'

P value = 0.00232 (Fisher's exact test), Q value = 0.021

Table S151.  Gene #36: 'del_4p16.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 9(4P16.2) MUTATED 28 0 7 49 2 0 6 8 25 24 34 12 0
DEL PEAK 9(4P16.2) WILD-TYPE 76 1 29 124 8 3 20 10 58 30 29 14 2

Figure S151.  Get High-res Image Gene #36: 'del_4p16.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_4p16.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.00053 (Fisher's exact test), Q value = 0.0066

Table S152.  Gene #36: 'del_4p16.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 9(4P16.2) MUTATED 91 57 51
DEL PEAK 9(4P16.2) WILD-TYPE 254 93 64

Figure S152.  Get High-res Image Gene #36: 'del_4p16.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_4p16.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.000424 (Fisher's exact test), Q value = 0.0056

Table S153.  Gene #36: 'del_4p16.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 9(4P16.2) MUTATED 130 43
DEL PEAK 9(4P16.2) WILD-TYPE 320 45

Figure S153.  Get High-res Image Gene #36: 'del_4p16.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_4p16.2' versus 'RADIATION_THERAPY'

P value = 0.0116 (Fisher's exact test), Q value = 0.068

Table S154.  Gene #36: 'del_4p16.2' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 9(4P16.2) MUTATED 142 16
DEL PEAK 9(4P16.2) WILD-TYPE 304 12

Figure S154.  Get High-res Image Gene #36: 'del_4p16.2' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_4p16.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0333 (Fisher's exact test), Q value = 0.14

Table S155.  Gene #36: 'del_4p16.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 9(4P16.2) MUTATED 124 11 57 4
DEL PEAK 9(4P16.2) WILD-TYPE 258 49 89 9

Figure S155.  Get High-res Image Gene #36: 'del_4p16.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_4p16.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00015 (Wilcoxon-test), Q value = 0.0024

Table S156.  Gene #36: 'del_4p16.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 9(4P16.2) MUTATED 189 3.2 (5.5)
DEL PEAK 9(4P16.2) WILD-TYPE 387 1.8 (4.2)

Figure S156.  Get High-res Image Gene #36: 'del_4p16.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_4q22.1' versus 'TUMOR_TISSUE_SITE'

P value = 0.0217 (Fisher's exact test), Q value = 0.11

Table S157.  Gene #37: 'del_4q22.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 10(4Q22.1) MUTATED 147 70
DEL PEAK 10(4Q22.1) WILD-TYPE 299 92

Figure S157.  Get High-res Image Gene #37: 'del_4q22.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_4q22.1' versus 'PATHOLOGIC_STAGE'

P value = 0.0413 (Fisher's exact test), Q value = 0.16

Table S158.  Gene #37: 'del_4q22.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 10(4Q22.1) MUTATED 26 0 11 59 2 1 6 7 37 28 27 11 1
DEL PEAK 10(4Q22.1) WILD-TYPE 78 1 25 114 8 2 20 11 46 26 36 15 1

Figure S158.  Get High-res Image Gene #37: 'del_4q22.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_4q22.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00041 (Fisher's exact test), Q value = 0.0055

Table S159.  Gene #37: 'del_4q22.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 10(4Q22.1) MUTATED 102 65 54
DEL PEAK 10(4Q22.1) WILD-TYPE 243 85 61

Figure S159.  Get High-res Image Gene #37: 'del_4q22.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_4q22.1' versus 'GENDER'

P value = 0.077 (Fisher's exact test), Q value = 0.23

Table S160.  Gene #37: 'del_4q22.1' versus Clinical Feature #8: 'GENDER'

nPatients FEMALE MALE
ALL 287 325
DEL PEAK 10(4Q22.1) MUTATED 93 128
DEL PEAK 10(4Q22.1) WILD-TYPE 194 197

Figure S160.  Get High-res Image Gene #37: 'del_4q22.1' versus Clinical Feature #8: 'GENDER'

'del_4q22.1' versus 'RADIATION_THERAPY'

P value = 0.07 (Fisher's exact test), Q value = 0.22

Table S161.  Gene #37: 'del_4q22.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 10(4Q22.1) MUTATED 160 15
DEL PEAK 10(4Q22.1) WILD-TYPE 286 13

Figure S161.  Get High-res Image Gene #37: 'del_4q22.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_4q22.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.00339 (Fisher's exact test), Q value = 0.029

Table S162.  Gene #37: 'del_4q22.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 10(4Q22.1) MUTATED 136 11 65 4
DEL PEAK 10(4Q22.1) WILD-TYPE 246 49 81 9

Figure S162.  Get High-res Image Gene #37: 'del_4q22.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_4q22.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000164 (Wilcoxon-test), Q value = 0.0026

Table S163.  Gene #37: 'del_4q22.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 10(4Q22.1) MUTATED 208 3.1 (5.5)
DEL PEAK 10(4Q22.1) WILD-TYPE 368 1.7 (4.2)

Figure S163.  Get High-res Image Gene #37: 'del_4q22.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_4q35.1' versus 'PATHOLOGIC_STAGE'

P value = 0.0685 (Fisher's exact test), Q value = 0.22

Table S164.  Gene #38: 'del_4q35.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 11(4Q35.1) MUTATED 31 0 9 63 1 1 9 7 35 29 30 10 1
DEL PEAK 11(4Q35.1) WILD-TYPE 73 1 27 110 9 2 17 11 48 25 33 16 1

Figure S164.  Get High-res Image Gene #38: 'del_4q35.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_4q35.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.00104 (Fisher's exact test), Q value = 0.011

Table S165.  Gene #38: 'del_4q35.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 11(4Q35.1) MUTATED 109 64 57
DEL PEAK 11(4Q35.1) WILD-TYPE 236 86 58

Figure S165.  Get High-res Image Gene #38: 'del_4q35.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_4q35.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.0712 (Fisher's exact test), Q value = 0.22

Table S166.  Gene #38: 'del_4q35.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 11(4Q35.1) MUTATED 162 41
DEL PEAK 11(4Q35.1) WILD-TYPE 288 47

Figure S166.  Get High-res Image Gene #38: 'del_4q35.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_4q35.1' versus 'RADIATION_THERAPY'

P value = 0.0446 (Fisher's exact test), Q value = 0.17

Table S167.  Gene #38: 'del_4q35.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 11(4Q35.1) MUTATED 166 16
DEL PEAK 11(4Q35.1) WILD-TYPE 280 12

Figure S167.  Get High-res Image Gene #38: 'del_4q35.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_4q35.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0644 (Fisher's exact test), Q value = 0.21

Table S168.  Gene #38: 'del_4q35.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 11(4Q35.1) MUTATED 140 16 65 3
DEL PEAK 11(4Q35.1) WILD-TYPE 242 44 81 10

Figure S168.  Get High-res Image Gene #38: 'del_4q35.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_4q35.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000309 (Wilcoxon-test), Q value = 0.0046

Table S169.  Gene #38: 'del_4q35.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 11(4Q35.1) MUTATED 217 2.9 (4.9)
DEL PEAK 11(4Q35.1) WILD-TYPE 359 1.8 (4.5)

Figure S169.  Get High-res Image Gene #38: 'del_4q35.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_5q12.1' versus 'TUMOR_TISSUE_SITE'

P value = 0.0278 (Fisher's exact test), Q value = 0.12

Table S170.  Gene #39: 'del_5q12.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 12(5Q12.1) MUTATED 105 53
DEL PEAK 12(5Q12.1) WILD-TYPE 341 109

Figure S170.  Get High-res Image Gene #39: 'del_5q12.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_5q12.1' versus 'PATHOLOGIC_STAGE'

P value = 0.0303 (Fisher's exact test), Q value = 0.13

Table S171.  Gene #39: 'del_5q12.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 12(5Q12.1) MUTATED 25 0 7 35 1 1 5 8 19 19 20 13 1
DEL PEAK 12(5Q12.1) WILD-TYPE 79 1 29 138 9 2 21 10 64 35 43 13 1

Figure S171.  Get High-res Image Gene #39: 'del_5q12.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_5q12.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.0355 (Fisher's exact test), Q value = 0.15

Table S172.  Gene #39: 'del_5q12.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 12(5Q12.1) MUTATED 76 44 38
DEL PEAK 12(5Q12.1) WILD-TYPE 269 106 77

Figure S172.  Get High-res Image Gene #39: 'del_5q12.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_5q12.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.0104 (Fisher's exact test), Q value = 0.064

Table S173.  Gene #39: 'del_5q12.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 12(5Q12.1) MUTATED 103 32
DEL PEAK 12(5Q12.1) WILD-TYPE 347 56

Figure S173.  Get High-res Image Gene #39: 'del_5q12.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_5q12.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0106 (Fisher's exact test), Q value = 0.066

Table S174.  Gene #39: 'del_5q12.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 12(5Q12.1) MUTATED 97 8 50 2
DEL PEAK 12(5Q12.1) WILD-TYPE 285 52 96 11

Figure S174.  Get High-res Image Gene #39: 'del_5q12.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_5q12.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0182 (Wilcoxon-test), Q value = 0.093

Table S175.  Gene #39: 'del_5q12.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 12(5Q12.1) MUTATED 152 3.0 (5.6)
DEL PEAK 12(5Q12.1) WILD-TYPE 424 2.0 (4.3)

Figure S175.  Get High-res Image Gene #39: 'del_5q12.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_5q21.2' versus 'PATHOLOGIC_STAGE'

P value = 0.00965 (Fisher's exact test), Q value = 0.06

Table S176.  Gene #40: 'del_5q21.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 13(5Q21.2) MUTATED 26 0 8 41 1 1 6 9 29 22 24 14 1
DEL PEAK 13(5Q21.2) WILD-TYPE 78 1 28 132 9 2 20 9 54 32 39 12 1

Figure S176.  Get High-res Image Gene #40: 'del_5q21.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_5q21.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.00154 (Fisher's exact test), Q value = 0.015

Table S177.  Gene #40: 'del_5q21.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 13(5Q21.2) MUTATED 85 56 45
DEL PEAK 13(5Q21.2) WILD-TYPE 260 94 70

Figure S177.  Get High-res Image Gene #40: 'del_5q21.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_5q21.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.0107 (Fisher's exact test), Q value = 0.066

Table S178.  Gene #40: 'del_5q21.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 13(5Q21.2) MUTATED 125 37
DEL PEAK 13(5Q21.2) WILD-TYPE 325 51

Figure S178.  Get High-res Image Gene #40: 'del_5q21.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_5q21.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0766 (Fisher's exact test), Q value = 0.23

Table S179.  Gene #40: 'del_5q21.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 13(5Q21.2) MUTATED 117 14 53 1
DEL PEAK 13(5Q21.2) WILD-TYPE 265 46 93 12

Figure S179.  Get High-res Image Gene #40: 'del_5q21.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_5q21.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00174 (Wilcoxon-test), Q value = 0.017

Table S180.  Gene #40: 'del_5q21.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 13(5Q21.2) MUTATED 179 2.8 (4.9)
DEL PEAK 13(5Q21.2) WILD-TYPE 397 2.0 (4.6)

Figure S180.  Get High-res Image Gene #40: 'del_5q21.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_5q22.2' versus 'PATHOLOGIC_STAGE'

P value = 0.0496 (Fisher's exact test), Q value = 0.18

Table S181.  Gene #41: 'del_5q22.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 14(5Q22.2) MUTATED 27 0 9 45 0 1 6 8 28 21 24 13 1
DEL PEAK 14(5Q22.2) WILD-TYPE 77 1 27 128 10 2 20 10 55 33 39 13 1

Figure S181.  Get High-res Image Gene #41: 'del_5q22.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_5q22.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.037 (Fisher's exact test), Q value = 0.15

Table S182.  Gene #41: 'del_5q22.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 14(5Q22.2) MUTATED 92 53 43
DEL PEAK 14(5Q22.2) WILD-TYPE 253 97 72

Figure S182.  Get High-res Image Gene #41: 'del_5q22.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_5q22.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.0158 (Fisher's exact test), Q value = 0.084

Table S183.  Gene #41: 'del_5q22.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 14(5Q22.2) MUTATED 125 36
DEL PEAK 14(5Q22.2) WILD-TYPE 325 52

Figure S183.  Get High-res Image Gene #41: 'del_5q22.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_5q22.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0589 (Fisher's exact test), Q value = 0.2

Table S184.  Gene #41: 'del_5q22.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 14(5Q22.2) MUTATED 116 13 56 2
DEL PEAK 14(5Q22.2) WILD-TYPE 266 47 90 11

Figure S184.  Get High-res Image Gene #41: 'del_5q22.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_5q22.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0234 (Wilcoxon-test), Q value = 0.11

Table S185.  Gene #41: 'del_5q22.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 14(5Q22.2) MUTATED 179 2.7 (4.9)
DEL PEAK 14(5Q22.2) WILD-TYPE 397 2.0 (4.6)

Figure S185.  Get High-res Image Gene #41: 'del_5q22.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_6p25.3' versus 'YEARS_TO_BIRTH'

P value = 0.0449 (Wilcoxon-test), Q value = 0.17

Table S186.  Gene #42: 'del_6p25.3' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
DEL PEAK 15(6P25.3) MUTATED 79 68.8 (12.3)
DEL PEAK 15(6P25.3) WILD-TYPE 531 65.9 (12.8)

Figure S186.  Get High-res Image Gene #42: 'del_6p25.3' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_6p25.3' versus 'GENDER'

P value = 0.0541 (Fisher's exact test), Q value = 0.19

Table S187.  Gene #42: 'del_6p25.3' versus Clinical Feature #8: 'GENDER'

nPatients FEMALE MALE
ALL 287 325
DEL PEAK 15(6P25.3) MUTATED 29 50
DEL PEAK 15(6P25.3) WILD-TYPE 258 275

Figure S187.  Get High-res Image Gene #42: 'del_6p25.3' versus Clinical Feature #8: 'GENDER'

'del_6p25.3' versus 'RADIATION_THERAPY'

P value = 0.0831 (Fisher's exact test), Q value = 0.24

Table S188.  Gene #42: 'del_6p25.3' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 15(6P25.3) MUTATED 57 7
DEL PEAK 15(6P25.3) WILD-TYPE 389 21

Figure S188.  Get High-res Image Gene #42: 'del_6p25.3' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_6p25.3' versus 'RACE'

P value = 0.00817 (Fisher's exact test), Q value = 0.054

Table S189.  Gene #42: 'del_6p25.3' versus Clinical Feature #13: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN WHITE
ALL 1 12 64 292
DEL PEAK 15(6P25.3) MUTATED 0 4 2 38
DEL PEAK 15(6P25.3) WILD-TYPE 1 8 62 254

Figure S189.  Get High-res Image Gene #42: 'del_6p25.3' versus Clinical Feature #13: 'RACE'

'del_6q26' versus 'Time to Death'

P value = 0.0313 (logrank test), Q value = 0.14

Table S190.  Gene #43: 'del_6q26' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 16(6Q26) MUTATED 86 23 0.5 - 131.5 (17.9)
DEL PEAK 16(6Q26) WILD-TYPE 507 98 0.0 - 148.0 (20.6)

Figure S190.  Get High-res Image Gene #43: 'del_6q26' versus Clinical Feature #1: 'Time to Death'

'del_6q26' versus 'PATHOLOGY_N_STAGE'

P value = 0.00118 (Fisher's exact test), Q value = 0.012

Table S191.  Gene #43: 'del_6q26' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 16(6Q26) MUTATED 42 18 30
DEL PEAK 16(6Q26) WILD-TYPE 303 132 85

Figure S191.  Get High-res Image Gene #43: 'del_6q26' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_6q26' versus 'RADIATION_THERAPY'

P value = 0.0522 (Fisher's exact test), Q value = 0.18

Table S192.  Gene #43: 'del_6q26' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 16(6Q26) MUTATED 63 8
DEL PEAK 16(6Q26) WILD-TYPE 383 20

Figure S192.  Get High-res Image Gene #43: 'del_6q26' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_6q26' versus 'HISTOLOGICAL_TYPE'

P value = 0.0337 (Fisher's exact test), Q value = 0.14

Table S193.  Gene #43: 'del_6q26' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 16(6Q26) MUTATED 52 8 22 6
DEL PEAK 16(6Q26) WILD-TYPE 330 52 124 7

Figure S193.  Get High-res Image Gene #43: 'del_6q26' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_6q26' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00233 (Wilcoxon-test), Q value = 0.021

Table S194.  Gene #43: 'del_6q26' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 16(6Q26) MUTATED 85 3.8 (6.0)
DEL PEAK 16(6Q26) WILD-TYPE 491 2.0 (4.4)

Figure S194.  Get High-res Image Gene #43: 'del_6q26' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_6q26' versus 'RACE'

P value = 0.0142 (Fisher's exact test), Q value = 0.078

Table S195.  Gene #43: 'del_6q26' versus Clinical Feature #13: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN WHITE
ALL 1 12 64 292
DEL PEAK 16(6Q26) MUTATED 1 4 5 39
DEL PEAK 16(6Q26) WILD-TYPE 0 8 59 253

Figure S195.  Get High-res Image Gene #43: 'del_6q26' versus Clinical Feature #13: 'RACE'

'del_7q31.1' versus 'RADIATION_THERAPY'

P value = 0.0434 (Fisher's exact test), Q value = 0.16

Table S196.  Gene #44: 'del_7q31.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 17(7Q31.1) MUTATED 11 3
DEL PEAK 17(7Q31.1) WILD-TYPE 435 25

Figure S196.  Get High-res Image Gene #44: 'del_7q31.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_7q31.1' versus 'ETHNICITY'

P value = 0.00841 (Fisher's exact test), Q value = 0.055

Table S197.  Gene #44: 'del_7q31.1' versus Clinical Feature #14: 'ETHNICITY'

nPatients HISPANIC OR LATINO NOT HISPANIC OR LATINO
ALL 5 348
DEL PEAK 17(7Q31.1) MUTATED 2 9
DEL PEAK 17(7Q31.1) WILD-TYPE 3 339

Figure S197.  Get High-res Image Gene #44: 'del_7q31.1' versus Clinical Feature #14: 'ETHNICITY'

'del_8p23.2' versus 'TUMOR_TISSUE_SITE'

P value = 7.37e-05 (Fisher's exact test), Q value = 0.0014

Table S198.  Gene #45: 'del_8p23.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 18(8P23.2) MUTATED 188 98
DEL PEAK 18(8P23.2) WILD-TYPE 258 64

Figure S198.  Get High-res Image Gene #45: 'del_8p23.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_8p23.2' versus 'PATHOLOGIC_STAGE'

P value = 3e-05 (Fisher's exact test), Q value = 0.00075

Table S199.  Gene #45: 'del_8p23.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 18(8P23.2) MUTATED 40 0 12 64 3 2 13 10 45 33 46 14 1
DEL PEAK 18(8P23.2) WILD-TYPE 64 1 24 109 7 1 13 8 38 21 17 12 1

Figure S199.  Get High-res Image Gene #45: 'del_8p23.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_8p23.2' versus 'PATHOLOGY_T_STAGE'

P value = 0.0669 (Fisher's exact test), Q value = 0.22

Table S200.  Gene #45: 'del_8p23.2' versus Clinical Feature #5: 'PATHOLOGY_T_STAGE'

nPatients T1 T2 T3 T4
ALL 20 106 417 67
DEL PEAK 18(8P23.2) MUTATED 4 47 203 34
DEL PEAK 18(8P23.2) WILD-TYPE 16 59 214 33

Figure S200.  Get High-res Image Gene #45: 'del_8p23.2' versus Clinical Feature #5: 'PATHOLOGY_T_STAGE'

'del_8p23.2' versus 'PATHOLOGY_N_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S201.  Gene #45: 'del_8p23.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 18(8P23.2) MUTATED 133 81 73
DEL PEAK 18(8P23.2) WILD-TYPE 212 69 42

Figure S201.  Get High-res Image Gene #45: 'del_8p23.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_8p23.2' versus 'PATHOLOGY_M_STAGE'

P value = 6.7e-05 (Fisher's exact test), Q value = 0.0013

Table S202.  Gene #45: 'del_8p23.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 18(8P23.2) MUTATED 197 59
DEL PEAK 18(8P23.2) WILD-TYPE 253 29

Figure S202.  Get High-res Image Gene #45: 'del_8p23.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_8p23.2' versus 'GENDER'

P value = 0.0353 (Fisher's exact test), Q value = 0.14

Table S203.  Gene #45: 'del_8p23.2' versus Clinical Feature #8: 'GENDER'

nPatients FEMALE MALE
ALL 287 325
DEL PEAK 18(8P23.2) MUTATED 122 166
DEL PEAK 18(8P23.2) WILD-TYPE 165 159

Figure S203.  Get High-res Image Gene #45: 'del_8p23.2' versus Clinical Feature #8: 'GENDER'

'del_8p23.2' versus 'HISTOLOGICAL_TYPE'

P value = 2e-05 (Fisher's exact test), Q value = 0.00054

Table S204.  Gene #45: 'del_8p23.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 18(8P23.2) MUTATED 170 15 89 7
DEL PEAK 18(8P23.2) WILD-TYPE 212 45 57 6

Figure S204.  Get High-res Image Gene #45: 'del_8p23.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_8p23.2' versus 'RESIDUAL_TUMOR'

P value = 0.00599 (Fisher's exact test), Q value = 0.043

Table S205.  Gene #45: 'del_8p23.2' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
DEL PEAK 18(8P23.2) MUTATED 199 2 26 9
DEL PEAK 18(8P23.2) WILD-TYPE 243 3 11 20

Figure S205.  Get High-res Image Gene #45: 'del_8p23.2' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'del_8p23.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 4.21e-06 (Wilcoxon-test), Q value = 0.00032

Table S206.  Gene #45: 'del_8p23.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 18(8P23.2) MUTATED 275 3.0 (5.8)
DEL PEAK 18(8P23.2) WILD-TYPE 301 1.5 (3.4)

Figure S206.  Get High-res Image Gene #45: 'del_8p23.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_8p22' versus 'Time to Death'

P value = 0.0298 (logrank test), Q value = 0.13

Table S207.  Gene #46: 'del_8p22' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 19(8P22) MUTATED 294 70 0.0 - 148.0 (20.1)
DEL PEAK 19(8P22) WILD-TYPE 299 51 0.0 - 139.2 (20.0)

Figure S207.  Get High-res Image Gene #46: 'del_8p22' versus Clinical Feature #1: 'Time to Death'

'del_8p22' versus 'TUMOR_TISSUE_SITE'

P value = 0.000931 (Fisher's exact test), Q value = 0.01

Table S208.  Gene #46: 'del_8p22' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 19(8P22) MUTATED 201 98
DEL PEAK 19(8P22) WILD-TYPE 245 64

Figure S208.  Get High-res Image Gene #46: 'del_8p22' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_8p22' versus 'PATHOLOGIC_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S209.  Gene #46: 'del_8p22' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 19(8P22) MUTATED 40 0 13 66 3 2 14 11 47 36 46 17 1
DEL PEAK 19(8P22) WILD-TYPE 64 1 23 107 7 1 12 7 36 18 17 9 1

Figure S209.  Get High-res Image Gene #46: 'del_8p22' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_8p22' versus 'PATHOLOGY_T_STAGE'

P value = 0.0226 (Fisher's exact test), Q value = 0.11

Table S210.  Gene #46: 'del_8p22' versus Clinical Feature #5: 'PATHOLOGY_T_STAGE'

nPatients T1 T2 T3 T4
ALL 20 106 417 67
DEL PEAK 19(8P22) MUTATED 4 47 213 37
DEL PEAK 19(8P22) WILD-TYPE 16 59 204 30

Figure S210.  Get High-res Image Gene #46: 'del_8p22' versus Clinical Feature #5: 'PATHOLOGY_T_STAGE'

'del_8p22' versus 'PATHOLOGY_N_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S211.  Gene #46: 'del_8p22' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 19(8P22) MUTATED 137 84 79
DEL PEAK 19(8P22) WILD-TYPE 208 66 36

Figure S211.  Get High-res Image Gene #46: 'del_8p22' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_8p22' versus 'PATHOLOGY_M_STAGE'

P value = 2.32e-05 (Fisher's exact test), Q value = 0.00061

Table S212.  Gene #46: 'del_8p22' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 19(8P22) MUTATED 206 62
DEL PEAK 19(8P22) WILD-TYPE 244 26

Figure S212.  Get High-res Image Gene #46: 'del_8p22' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_8p22' versus 'HISTOLOGICAL_TYPE'

P value = 9e-05 (Fisher's exact test), Q value = 0.0016

Table S213.  Gene #46: 'del_8p22' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 19(8P22) MUTATED 182 16 89 7
DEL PEAK 19(8P22) WILD-TYPE 200 44 57 6

Figure S213.  Get High-res Image Gene #46: 'del_8p22' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_8p22' versus 'RESIDUAL_TUMOR'

P value = 0.0045 (Fisher's exact test), Q value = 0.035

Table S214.  Gene #46: 'del_8p22' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
DEL PEAK 19(8P22) MUTATED 212 2 26 8
DEL PEAK 19(8P22) WILD-TYPE 230 3 11 21

Figure S214.  Get High-res Image Gene #46: 'del_8p22' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'del_8p22' versus 'NUMBER_OF_LYMPH_NODES'

P value = 7.99e-08 (Wilcoxon-test), Q value = 2.7e-05

Table S215.  Gene #46: 'del_8p22' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 19(8P22) MUTATED 289 3.0 (5.7)
DEL PEAK 19(8P22) WILD-TYPE 287 1.4 (3.3)

Figure S215.  Get High-res Image Gene #46: 'del_8p22' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_8q11.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.0589 (Fisher's exact test), Q value = 0.2

Table S216.  Gene #47: 'del_8q11.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 20(8Q11.1) MUTATED 19 16 12
DEL PEAK 20(8Q11.1) WILD-TYPE 326 134 103

Figure S216.  Get High-res Image Gene #47: 'del_8q11.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_8q11.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0274 (Wilcoxon-test), Q value = 0.12

Table S217.  Gene #47: 'del_8q11.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 20(8Q11.1) MUTATED 47 2.7 (3.8)
DEL PEAK 20(8Q11.1) WILD-TYPE 529 2.2 (4.8)

Figure S217.  Get High-res Image Gene #47: 'del_8q11.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_9p24.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.0671 (Fisher's exact test), Q value = 0.22

Table S218.  Gene #48: 'del_9p24.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 21(9P24.2) MUTATED 58 18
DEL PEAK 21(9P24.2) WILD-TYPE 392 70

Figure S218.  Get High-res Image Gene #48: 'del_9p24.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_9p24.2' versus 'GENDER'

P value = 0.0439 (Fisher's exact test), Q value = 0.16

Table S219.  Gene #48: 'del_9p24.2' versus Clinical Feature #8: 'GENDER'

nPatients FEMALE MALE
ALL 287 325
DEL PEAK 21(9P24.2) MUTATED 30 53
DEL PEAK 21(9P24.2) WILD-TYPE 257 272

Figure S219.  Get High-res Image Gene #48: 'del_9p24.2' versus Clinical Feature #8: 'GENDER'

'del_9p24.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0386 (Fisher's exact test), Q value = 0.15

Table S220.  Gene #48: 'del_9p24.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 21(9P24.2) MUTATED 53 2 25 1
DEL PEAK 21(9P24.2) WILD-TYPE 329 58 121 12

Figure S220.  Get High-res Image Gene #48: 'del_9p24.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_9p24.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0449 (Wilcoxon-test), Q value = 0.17

Table S221.  Gene #48: 'del_9p24.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 21(9P24.2) MUTATED 77 2.8 (5.0)
DEL PEAK 21(9P24.2) WILD-TYPE 499 2.1 (4.7)

Figure S221.  Get High-res Image Gene #48: 'del_9p24.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_10p15.3' versus 'YEARS_TO_BIRTH'

P value = 0.0319 (Wilcoxon-test), Q value = 0.14

Table S222.  Gene #49: 'del_10p15.3' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
DEL PEAK 22(10P15.3) MUTATED 112 63.8 (13.2)
DEL PEAK 22(10P15.3) WILD-TYPE 498 66.8 (12.6)

Figure S222.  Get High-res Image Gene #49: 'del_10p15.3' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_10p15.3' versus 'PATHOLOGIC_STAGE'

P value = 0.045 (Fisher's exact test), Q value = 0.17

Table S223.  Gene #49: 'del_10p15.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 22(10P15.3) MUTATED 19 0 6 21 0 1 2 6 16 13 17 7 1
DEL PEAK 22(10P15.3) WILD-TYPE 85 1 30 152 10 2 24 12 67 41 46 19 1

Figure S223.  Get High-res Image Gene #49: 'del_10p15.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_10p15.3' versus 'PATHOLOGY_N_STAGE'

P value = 0.0233 (Fisher's exact test), Q value = 0.11

Table S224.  Gene #49: 'del_10p15.3' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 22(10P15.3) MUTATED 51 32 29
DEL PEAK 22(10P15.3) WILD-TYPE 294 118 86

Figure S224.  Get High-res Image Gene #49: 'del_10p15.3' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_10p15.3' versus 'PATHOLOGY_M_STAGE'

P value = 0.0357 (Fisher's exact test), Q value = 0.15

Table S225.  Gene #49: 'del_10p15.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 22(10P15.3) MUTATED 77 24
DEL PEAK 22(10P15.3) WILD-TYPE 373 64

Figure S225.  Get High-res Image Gene #49: 'del_10p15.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_10p15.3' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00412 (Wilcoxon-test), Q value = 0.033

Table S226.  Gene #49: 'del_10p15.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 22(10P15.3) MUTATED 108 3.2 (6.5)
DEL PEAK 22(10P15.3) WILD-TYPE 468 2.0 (4.2)

Figure S226.  Get High-res Image Gene #49: 'del_10p15.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_10q21.1' versus 'YEARS_TO_BIRTH'

P value = 0.0474 (Wilcoxon-test), Q value = 0.17

Table S227.  Gene #50: 'del_10q21.1' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
DEL PEAK 23(10Q21.1) MUTATED 137 64.2 (12.8)
DEL PEAK 23(10Q21.1) WILD-TYPE 473 66.9 (12.7)

Figure S227.  Get High-res Image Gene #50: 'del_10q21.1' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_10q21.1' versus 'RADIATION_THERAPY'

P value = 0.00209 (Fisher's exact test), Q value = 0.02

Table S228.  Gene #50: 'del_10q21.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 23(10Q21.1) MUTATED 99 14
DEL PEAK 23(10Q21.1) WILD-TYPE 347 14

Figure S228.  Get High-res Image Gene #50: 'del_10q21.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_10q21.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0353 (Fisher's exact test), Q value = 0.14

Table S229.  Gene #50: 'del_10q21.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 23(10Q21.1) MUTATED 89 7 34 6
DEL PEAK 23(10Q21.1) WILD-TYPE 293 53 112 7

Figure S229.  Get High-res Image Gene #50: 'del_10q21.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_10q21.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0393 (Wilcoxon-test), Q value = 0.15

Table S230.  Gene #50: 'del_10q21.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 23(10Q21.1) MUTATED 132 2.8 (6.0)
DEL PEAK 23(10Q21.1) WILD-TYPE 444 2.1 (4.2)

Figure S230.  Get High-res Image Gene #50: 'del_10q21.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_10q21.1' versus 'ETHNICITY'

P value = 0.0113 (Fisher's exact test), Q value = 0.067

Table S231.  Gene #50: 'del_10q21.1' versus Clinical Feature #14: 'ETHNICITY'

nPatients HISPANIC OR LATINO NOT HISPANIC OR LATINO
ALL 5 348
DEL PEAK 23(10Q21.1) MUTATED 4 78
DEL PEAK 23(10Q21.1) WILD-TYPE 1 270

Figure S231.  Get High-res Image Gene #50: 'del_10q21.1' versus Clinical Feature #14: 'ETHNICITY'

'del_10q23.31' versus 'YEARS_TO_BIRTH'

P value = 0.00466 (Wilcoxon-test), Q value = 0.036

Table S232.  Gene #51: 'del_10q23.31' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
DEL PEAK 24(10Q23.31) MUTATED 159 63.8 (12.7)
DEL PEAK 24(10Q23.31) WILD-TYPE 451 67.2 (12.7)

Figure S232.  Get High-res Image Gene #51: 'del_10q23.31' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_10q23.31' versus 'TUMOR_TISSUE_SITE'

P value = 0.0751 (Fisher's exact test), Q value = 0.23

Table S233.  Gene #51: 'del_10q23.31' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 24(10Q23.31) MUTATED 107 51
DEL PEAK 24(10Q23.31) WILD-TYPE 339 111

Figure S233.  Get High-res Image Gene #51: 'del_10q23.31' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_10q23.31' versus 'PATHOLOGIC_STAGE'

P value = 0.0508 (Fisher's exact test), Q value = 0.18

Table S234.  Gene #51: 'del_10q23.31' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 24(10Q23.31) MUTATED 21 1 6 41 2 1 6 9 22 17 22 6 2
DEL PEAK 24(10Q23.31) WILD-TYPE 83 0 30 132 8 2 20 9 61 37 41 20 0

Figure S234.  Get High-res Image Gene #51: 'del_10q23.31' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_10q23.31' versus 'PATHOLOGY_N_STAGE'

P value = 0.0591 (Fisher's exact test), Q value = 0.2

Table S235.  Gene #51: 'del_10q23.31' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 24(10Q23.31) MUTATED 77 44 37
DEL PEAK 24(10Q23.31) WILD-TYPE 268 106 78

Figure S235.  Get High-res Image Gene #51: 'del_10q23.31' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_10q23.31' versus 'RADIATION_THERAPY'

P value = 0.0279 (Fisher's exact test), Q value = 0.12

Table S236.  Gene #51: 'del_10q23.31' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 24(10Q23.31) MUTATED 117 13
DEL PEAK 24(10Q23.31) WILD-TYPE 329 15

Figure S236.  Get High-res Image Gene #51: 'del_10q23.31' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_10q23.31' versus 'HISTOLOGICAL_TYPE'

P value = 0.0216 (Fisher's exact test), Q value = 0.11

Table S237.  Gene #51: 'del_10q23.31' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 24(10Q23.31) MUTATED 96 9 42 7
DEL PEAK 24(10Q23.31) WILD-TYPE 286 51 104 6

Figure S237.  Get High-res Image Gene #51: 'del_10q23.31' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_10q23.31' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0121 (Wilcoxon-test), Q value = 0.07

Table S238.  Gene #51: 'del_10q23.31' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 24(10Q23.31) MUTATED 152 2.5 (4.3)
DEL PEAK 24(10Q23.31) WILD-TYPE 424 2.1 (4.8)

Figure S238.  Get High-res Image Gene #51: 'del_10q23.31' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_10q25.2' versus 'YEARS_TO_BIRTH'

P value = 0.0493 (Wilcoxon-test), Q value = 0.18

Table S239.  Gene #52: 'del_10q25.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
DEL PEAK 25(10Q25.2) MUTATED 155 64.5 (12.7)
DEL PEAK 25(10Q25.2) WILD-TYPE 455 66.9 (12.7)

Figure S239.  Get High-res Image Gene #52: 'del_10q25.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_10q25.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.0309 (Fisher's exact test), Q value = 0.13

Table S240.  Gene #52: 'del_10q25.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 25(10Q25.2) MUTATED 74 42 38
DEL PEAK 25(10Q25.2) WILD-TYPE 271 108 77

Figure S240.  Get High-res Image Gene #52: 'del_10q25.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_10q25.2' versus 'RADIATION_THERAPY'

P value = 0.0413 (Fisher's exact test), Q value = 0.16

Table S241.  Gene #52: 'del_10q25.2' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 25(10Q25.2) MUTATED 108 12
DEL PEAK 25(10Q25.2) WILD-TYPE 338 16

Figure S241.  Get High-res Image Gene #52: 'del_10q25.2' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_10q25.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0302 (Fisher's exact test), Q value = 0.13

Table S242.  Gene #52: 'del_10q25.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 25(10Q25.2) MUTATED 97 9 39 7
DEL PEAK 25(10Q25.2) WILD-TYPE 285 51 107 6

Figure S242.  Get High-res Image Gene #52: 'del_10q25.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_10q25.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0173 (Wilcoxon-test), Q value = 0.089

Table S243.  Gene #52: 'del_10q25.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 25(10Q25.2) MUTATED 149 2.6 (4.4)
DEL PEAK 25(10Q25.2) WILD-TYPE 427 2.1 (4.8)

Figure S243.  Get High-res Image Gene #52: 'del_10q25.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_11q22.3' versus 'TUMOR_TISSUE_SITE'

P value = 0.0697 (Fisher's exact test), Q value = 0.22

Table S244.  Gene #53: 'del_11q22.3' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 26(11Q22.3) MUTATED 70 36
DEL PEAK 26(11Q22.3) WILD-TYPE 376 126

Figure S244.  Get High-res Image Gene #53: 'del_11q22.3' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_11q22.3' versus 'RADIATION_THERAPY'

P value = 0.0759 (Fisher's exact test), Q value = 0.23

Table S245.  Gene #53: 'del_11q22.3' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 26(11Q22.3) MUTATED 79 9
DEL PEAK 26(11Q22.3) WILD-TYPE 367 19

Figure S245.  Get High-res Image Gene #53: 'del_11q22.3' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_11q22.3' versus 'HISTOLOGICAL_TYPE'

P value = 0.0419 (Fisher's exact test), Q value = 0.16

Table S246.  Gene #53: 'del_11q22.3' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 26(11Q22.3) MUTATED 62 8 29 6
DEL PEAK 26(11Q22.3) WILD-TYPE 320 52 117 7

Figure S246.  Get High-res Image Gene #53: 'del_11q22.3' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_11q22.3' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0663 (Wilcoxon-test), Q value = 0.22

Table S247.  Gene #53: 'del_11q22.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 26(11Q22.3) MUTATED 106 3.1 (5.9)
DEL PEAK 26(11Q22.3) WILD-TYPE 470 2.0 (4.4)

Figure S247.  Get High-res Image Gene #53: 'del_11q22.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_12p13.1' versus 'Time to Death'

P value = 0.0631 (logrank test), Q value = 0.21

Table S248.  Gene #54: 'del_12p13.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 27(12P13.1) MUTATED 89 24 0.1 - 78.1 (20.0)
DEL PEAK 27(12P13.1) WILD-TYPE 504 97 0.0 - 148.0 (20.0)

Figure S248.  Get High-res Image Gene #54: 'del_12p13.1' versus Clinical Feature #1: 'Time to Death'

'del_12p13.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.0262 (Fisher's exact test), Q value = 0.12

Table S249.  Gene #54: 'del_12p13.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 27(12P13.1) MUTATED 41 32 18
DEL PEAK 27(12P13.1) WILD-TYPE 304 118 97

Figure S249.  Get High-res Image Gene #54: 'del_12p13.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_12p13.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.043 (Fisher's exact test), Q value = 0.16

Table S250.  Gene #54: 'del_12p13.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 27(12P13.1) MUTATED 57 19
DEL PEAK 27(12P13.1) WILD-TYPE 393 69

Figure S250.  Get High-res Image Gene #54: 'del_12p13.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_12p13.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0155 (Fisher's exact test), Q value = 0.083

Table S251.  Gene #54: 'del_12p13.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 27(12P13.1) MUTATED 56 2 28 1
DEL PEAK 27(12P13.1) WILD-TYPE 326 58 118 12

Figure S251.  Get High-res Image Gene #54: 'del_12p13.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_12q21.33' versus 'Time to Death'

P value = 0.0721 (logrank test), Q value = 0.22

Table S252.  Gene #55: 'del_12q21.33' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 28(12Q21.33) MUTATED 86 23 0.7 - 129.3 (22.2)
DEL PEAK 28(12Q21.33) WILD-TYPE 507 98 0.0 - 148.0 (20.0)

Figure S252.  Get High-res Image Gene #55: 'del_12q21.33' versus Clinical Feature #1: 'Time to Death'

'del_12q21.33' versus 'PATHOLOGIC_STAGE'

P value = 0.0517 (Fisher's exact test), Q value = 0.18

Table S253.  Gene #55: 'del_12q21.33' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 28(12Q21.33) MUTATED 15 0 3 19 1 2 1 4 11 14 11 4 1
DEL PEAK 28(12Q21.33) WILD-TYPE 89 1 33 154 9 1 25 14 72 40 52 22 1

Figure S253.  Get High-res Image Gene #55: 'del_12q21.33' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_12q21.33' versus 'HISTOLOGICAL_TYPE'

P value = 0.0273 (Fisher's exact test), Q value = 0.12

Table S254.  Gene #55: 'del_12q21.33' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 28(12Q21.33) MUTATED 58 2 26 1
DEL PEAK 28(12Q21.33) WILD-TYPE 324 58 120 12

Figure S254.  Get High-res Image Gene #55: 'del_12q21.33' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_12q21.33' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0258 (Wilcoxon-test), Q value = 0.12

Table S255.  Gene #55: 'del_12q21.33' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 28(12Q21.33) MUTATED 86 2.9 (4.9)
DEL PEAK 28(12Q21.33) WILD-TYPE 490 2.1 (4.7)

Figure S255.  Get High-res Image Gene #55: 'del_12q21.33' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_14q11.2' versus 'TUMOR_TISSUE_SITE'

P value = 0.0119 (Fisher's exact test), Q value = 0.069

Table S256.  Gene #56: 'del_14q11.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 29(14Q11.2) MUTATED 138 68
DEL PEAK 29(14Q11.2) WILD-TYPE 308 94

Figure S256.  Get High-res Image Gene #56: 'del_14q11.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_14q11.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.0428 (Fisher's exact test), Q value = 0.16

Table S257.  Gene #56: 'del_14q11.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 29(14Q11.2) MUTATED 107 64 38
DEL PEAK 29(14Q11.2) WILD-TYPE 238 86 77

Figure S257.  Get High-res Image Gene #56: 'del_14q11.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_14q11.2' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S258.  Gene #56: 'del_14q11.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 29(14Q11.2) MUTATED 132 4 66 2
DEL PEAK 29(14Q11.2) WILD-TYPE 250 56 80 11

Figure S258.  Get High-res Image Gene #56: 'del_14q11.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_14q31.1' versus 'TUMOR_TISSUE_SITE'

P value = 0.0345 (Fisher's exact test), Q value = 0.14

Table S259.  Gene #57: 'del_14q31.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 30(14Q31.1) MUTATED 145 68
DEL PEAK 30(14Q31.1) WILD-TYPE 301 94

Figure S259.  Get High-res Image Gene #57: 'del_14q31.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_14q31.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.0342 (Fisher's exact test), Q value = 0.14

Table S260.  Gene #57: 'del_14q31.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 30(14Q31.1) MUTATED 108 65 42
DEL PEAK 30(14Q31.1) WILD-TYPE 237 85 73

Figure S260.  Get High-res Image Gene #57: 'del_14q31.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_14q31.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.0288 (Fisher's exact test), Q value = 0.13

Table S261.  Gene #57: 'del_14q31.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 30(14Q31.1) MUTATED 153 41
DEL PEAK 30(14Q31.1) WILD-TYPE 297 47

Figure S261.  Get High-res Image Gene #57: 'del_14q31.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_14q31.1' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S262.  Gene #57: 'del_14q31.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 30(14Q31.1) MUTATED 138 4 65 1
DEL PEAK 30(14Q31.1) WILD-TYPE 244 56 81 12

Figure S262.  Get High-res Image Gene #57: 'del_14q31.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_14q31.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0486 (Wilcoxon-test), Q value = 0.18

Table S263.  Gene #57: 'del_14q31.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 30(14Q31.1) MUTATED 201 2.6 (5.0)
DEL PEAK 30(14Q31.1) WILD-TYPE 375 2.1 (4.5)

Figure S263.  Get High-res Image Gene #57: 'del_14q31.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_15q11.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.022 (Fisher's exact test), Q value = 0.11

Table S264.  Gene #58: 'del_15q11.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 31(15Q11.2) MUTATED 126 72 54
DEL PEAK 31(15Q11.2) WILD-TYPE 219 78 61

Figure S264.  Get High-res Image Gene #58: 'del_15q11.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_15q11.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.0328 (Fisher's exact test), Q value = 0.14

Table S265.  Gene #58: 'del_15q11.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 31(15Q11.2) MUTATED 177 46
DEL PEAK 31(15Q11.2) WILD-TYPE 273 42

Figure S265.  Get High-res Image Gene #58: 'del_15q11.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_15q11.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0763 (Fisher's exact test), Q value = 0.23

Table S266.  Gene #58: 'del_15q11.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 31(15Q11.2) MUTATED 157 16 67 6
DEL PEAK 31(15Q11.2) WILD-TYPE 225 44 79 7

Figure S266.  Get High-res Image Gene #58: 'del_15q11.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_15q11.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00509 (Wilcoxon-test), Q value = 0.038

Table S267.  Gene #58: 'del_15q11.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 31(15Q11.2) MUTATED 236 2.7 (4.7)
DEL PEAK 31(15Q11.2) WILD-TYPE 340 1.9 (4.7)

Figure S267.  Get High-res Image Gene #58: 'del_15q11.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_15q15.2' versus 'TUMOR_TISSUE_SITE'

P value = 0.0401 (Fisher's exact test), Q value = 0.16

Table S268.  Gene #59: 'del_15q15.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 32(15Q15.2) MUTATED 170 77
DEL PEAK 32(15Q15.2) WILD-TYPE 276 85

Figure S268.  Get High-res Image Gene #59: 'del_15q15.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_15q15.2' versus 'PATHOLOGIC_STAGE'

P value = 0.0629 (Fisher's exact test), Q value = 0.21

Table S269.  Gene #59: 'del_15q15.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 32(15Q15.2) MUTATED 41 0 8 62 3 2 10 8 35 27 34 13 2
DEL PEAK 32(15Q15.2) WILD-TYPE 63 1 28 111 7 1 16 10 48 27 29 13 0

Figure S269.  Get High-res Image Gene #59: 'del_15q15.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_15q15.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.007 (Fisher's exact test), Q value = 0.048

Table S270.  Gene #59: 'del_15q15.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 32(15Q15.2) MUTATED 123 75 52
DEL PEAK 32(15Q15.2) WILD-TYPE 222 75 63

Figure S270.  Get High-res Image Gene #59: 'del_15q15.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_15q15.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.00442 (Fisher's exact test), Q value = 0.035

Table S271.  Gene #59: 'del_15q15.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 32(15Q15.2) MUTATED 171 48
DEL PEAK 32(15Q15.2) WILD-TYPE 279 40

Figure S271.  Get High-res Image Gene #59: 'del_15q15.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_15q15.2' versus 'HISTOLOGICAL_TYPE'

P value = 0.0198 (Fisher's exact test), Q value = 0.099

Table S272.  Gene #59: 'del_15q15.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 32(15Q15.2) MUTATED 153 15 70 6
DEL PEAK 32(15Q15.2) WILD-TYPE 229 45 76 7

Figure S272.  Get High-res Image Gene #59: 'del_15q15.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_15q15.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.00321 (Wilcoxon-test), Q value = 0.028

Table S273.  Gene #59: 'del_15q15.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 32(15Q15.2) MUTATED 235 2.7 (4.8)
DEL PEAK 32(15Q15.2) WILD-TYPE 341 1.9 (4.6)

Figure S273.  Get High-res Image Gene #59: 'del_15q15.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_15q21.1' versus 'TUMOR_TISSUE_SITE'

P value = 0.0316 (Fisher's exact test), Q value = 0.14

Table S274.  Gene #60: 'del_15q21.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 33(15Q21.1) MUTATED 168 77
DEL PEAK 33(15Q21.1) WILD-TYPE 278 85

Figure S274.  Get High-res Image Gene #60: 'del_15q21.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_15q21.1' versus 'PATHOLOGY_N_STAGE'

P value = 0.0267 (Fisher's exact test), Q value = 0.12

Table S275.  Gene #60: 'del_15q21.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 33(15Q21.1) MUTATED 124 72 51
DEL PEAK 33(15Q21.1) WILD-TYPE 221 78 64

Figure S275.  Get High-res Image Gene #60: 'del_15q21.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_15q21.1' versus 'PATHOLOGY_M_STAGE'

P value = 0.00868 (Fisher's exact test), Q value = 0.057

Table S276.  Gene #60: 'del_15q21.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 33(15Q21.1) MUTATED 170 47
DEL PEAK 33(15Q21.1) WILD-TYPE 280 41

Figure S276.  Get High-res Image Gene #60: 'del_15q21.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_15q21.1' versus 'RADIATION_THERAPY'

P value = 0.075 (Fisher's exact test), Q value = 0.23

Table S277.  Gene #60: 'del_15q21.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 33(15Q21.1) MUTATED 176 16
DEL PEAK 33(15Q21.1) WILD-TYPE 270 12

Figure S277.  Get High-res Image Gene #60: 'del_15q21.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_15q21.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.019 (Fisher's exact test), Q value = 0.096

Table S278.  Gene #60: 'del_15q21.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 33(15Q21.1) MUTATED 151 15 70 6
DEL PEAK 33(15Q21.1) WILD-TYPE 231 45 76 7

Figure S278.  Get High-res Image Gene #60: 'del_15q21.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_15q21.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0109 (Wilcoxon-test), Q value = 0.066

Table S279.  Gene #60: 'del_15q21.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 33(15Q21.1) MUTATED 232 2.7 (4.9)
DEL PEAK 33(15Q21.1) WILD-TYPE 344 1.9 (4.6)

Figure S279.  Get High-res Image Gene #60: 'del_15q21.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_15q22.33' versus 'TUMOR_TISSUE_SITE'

P value = 0.0186 (Fisher's exact test), Q value = 0.094

Table S280.  Gene #61: 'del_15q22.33' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 34(15Q22.33) MUTATED 159 75
DEL PEAK 34(15Q22.33) WILD-TYPE 287 87

Figure S280.  Get High-res Image Gene #61: 'del_15q22.33' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_15q22.33' versus 'PATHOLOGIC_STAGE'

P value = 0.0146 (Fisher's exact test), Q value = 0.079

Table S281.  Gene #61: 'del_15q22.33' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 34(15Q22.33) MUTATED 32 0 7 62 3 2 8 9 34 28 32 14 1
DEL PEAK 34(15Q22.33) WILD-TYPE 72 1 29 111 7 1 18 9 49 26 31 12 1

Figure S281.  Get High-res Image Gene #61: 'del_15q22.33' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_15q22.33' versus 'PATHOLOGY_T_STAGE'

P value = 0.0854 (Fisher's exact test), Q value = 0.25

Table S282.  Gene #61: 'del_15q22.33' versus Clinical Feature #5: 'PATHOLOGY_T_STAGE'

nPatients T1 T2 T3 T4
ALL 20 106 417 67
DEL PEAK 34(15Q22.33) MUTATED 9 31 174 23
DEL PEAK 34(15Q22.33) WILD-TYPE 11 75 243 44

Figure S282.  Get High-res Image Gene #61: 'del_15q22.33' versus Clinical Feature #5: 'PATHOLOGY_T_STAGE'

'del_15q22.33' versus 'PATHOLOGY_N_STAGE'

P value = 0.0037 (Fisher's exact test), Q value = 0.031

Table S283.  Gene #61: 'del_15q22.33' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 34(15Q22.33) MUTATED 114 69 54
DEL PEAK 34(15Q22.33) WILD-TYPE 231 81 61

Figure S283.  Get High-res Image Gene #61: 'del_15q22.33' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_15q22.33' versus 'PATHOLOGY_M_STAGE'

P value = 0.0041 (Fisher's exact test), Q value = 0.033

Table S284.  Gene #61: 'del_15q22.33' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 34(15Q22.33) MUTATED 161 46
DEL PEAK 34(15Q22.33) WILD-TYPE 289 42

Figure S284.  Get High-res Image Gene #61: 'del_15q22.33' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_15q22.33' versus 'HISTOLOGICAL_TYPE'

P value = 0.0132 (Fisher's exact test), Q value = 0.075

Table S285.  Gene #61: 'del_15q22.33' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 34(15Q22.33) MUTATED 143 14 68 6
DEL PEAK 34(15Q22.33) WILD-TYPE 239 46 78 7

Figure S285.  Get High-res Image Gene #61: 'del_15q22.33' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_15q22.33' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000932 (Wilcoxon-test), Q value = 0.01

Table S286.  Gene #61: 'del_15q22.33' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 34(15Q22.33) MUTATED 223 2.8 (4.9)
DEL PEAK 34(15Q22.33) WILD-TYPE 353 1.9 (4.6)

Figure S286.  Get High-res Image Gene #61: 'del_15q22.33' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_16p13.3' versus 'Time to Death'

P value = 0.00665 (logrank test), Q value = 0.047

Table S287.  Gene #62: 'del_16p13.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 35(16P13.3) MUTATED 65 20 0.5 - 61.8 (18.3)
DEL PEAK 35(16P13.3) WILD-TYPE 528 101 0.0 - 148.0 (20.0)

Figure S287.  Get High-res Image Gene #62: 'del_16p13.3' versus Clinical Feature #1: 'Time to Death'

'del_16p13.3' versus 'PATHOLOGIC_STAGE'

P value = 0.0132 (Fisher's exact test), Q value = 0.075

Table S288.  Gene #62: 'del_16p13.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 35(16P13.3) MUTATED 4 0 3 24 2 1 0 0 9 11 8 5 0
DEL PEAK 35(16P13.3) WILD-TYPE 100 1 33 149 8 2 26 18 74 43 55 21 2

Figure S288.  Get High-res Image Gene #62: 'del_16p13.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_16p13.3' versus 'PATHOLOGY_T_STAGE'

P value = 0.052 (Fisher's exact test), Q value = 0.18

Table S289.  Gene #62: 'del_16p13.3' versus Clinical Feature #5: 'PATHOLOGY_T_STAGE'

nPatients T1 T2 T3 T4
ALL 20 106 417 67
DEL PEAK 35(16P13.3) MUTATED 0 6 55 7
DEL PEAK 35(16P13.3) WILD-TYPE 20 100 362 60

Figure S289.  Get High-res Image Gene #62: 'del_16p13.3' versus Clinical Feature #5: 'PATHOLOGY_T_STAGE'

'del_16q23.1' versus 'Time to Death'

P value = 0.0337 (logrank test), Q value = 0.14

Table S290.  Gene #63: 'del_16q23.1' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 36(16Q23.1) MUTATED 82 20 0.5 - 129.3 (18.0)
DEL PEAK 36(16Q23.1) WILD-TYPE 511 101 0.0 - 148.0 (20.1)

Figure S290.  Get High-res Image Gene #63: 'del_16q23.1' versus Clinical Feature #1: 'Time to Death'

'del_17p12' versus 'TUMOR_TISSUE_SITE'

P value = 0.00271 (Fisher's exact test), Q value = 0.024

Table S291.  Gene #64: 'del_17p12' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 37(17P12) MUTATED 250 113
DEL PEAK 37(17P12) WILD-TYPE 196 49

Figure S291.  Get High-res Image Gene #64: 'del_17p12' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_17p12' versus 'PATHOLOGIC_STAGE'

P value = 0.00037 (Fisher's exact test), Q value = 0.0053

Table S292.  Gene #64: 'del_17p12' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 37(17P12) MUTATED 53 0 19 89 3 1 17 14 54 41 46 20 2
DEL PEAK 37(17P12) WILD-TYPE 51 1 17 84 7 2 9 4 29 13 17 6 0

Figure S292.  Get High-res Image Gene #64: 'del_17p12' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_17p12' versus 'PATHOLOGY_N_STAGE'

P value = 2e-05 (Fisher's exact test), Q value = 0.00054

Table S293.  Gene #64: 'del_17p12' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 37(17P12) MUTATED 180 103 83
DEL PEAK 37(17P12) WILD-TYPE 165 47 32

Figure S293.  Get High-res Image Gene #64: 'del_17p12' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_17p12' versus 'PATHOLOGY_M_STAGE'

P value = 0.00273 (Fisher's exact test), Q value = 0.024

Table S294.  Gene #64: 'del_17p12' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 37(17P12) MUTATED 260 66
DEL PEAK 37(17P12) WILD-TYPE 190 22

Figure S294.  Get High-res Image Gene #64: 'del_17p12' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_17p12' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S295.  Gene #64: 'del_17p12' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 37(17P12) MUTATED 231 16 105 6
DEL PEAK 37(17P12) WILD-TYPE 151 44 41 7

Figure S295.  Get High-res Image Gene #64: 'del_17p12' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_17p12' versus 'NUMBER_OF_LYMPH_NODES'

P value = 1.53e-05 (Wilcoxon-test), Q value = 0.00048

Table S296.  Gene #64: 'del_17p12' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 37(17P12) MUTATED 345 2.7 (5.2)
DEL PEAK 37(17P12) WILD-TYPE 231 1.6 (3.8)

Figure S296.  Get High-res Image Gene #64: 'del_17p12' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_17q24.3' versus 'Time to Death'

P value = 0.0759 (logrank test), Q value = 0.23

Table S297.  Gene #65: 'del_17q24.3' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 38(17Q24.3) MUTATED 93 24 0.2 - 140.4 (20.0)
DEL PEAK 38(17Q24.3) WILD-TYPE 500 97 0.0 - 148.0 (20.0)

Figure S297.  Get High-res Image Gene #65: 'del_17q24.3' versus Clinical Feature #1: 'Time to Death'

'del_17q24.3' versus 'PATHOLOGIC_STAGE'

P value = 0.00594 (Fisher's exact test), Q value = 0.043

Table S298.  Gene #65: 'del_17q24.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 38(17Q24.3) MUTATED 15 0 5 15 0 0 4 5 11 15 12 9 1
DEL PEAK 38(17Q24.3) WILD-TYPE 89 1 31 158 10 3 22 13 72 39 51 17 1

Figure S298.  Get High-res Image Gene #65: 'del_17q24.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_17q24.3' versus 'PATHOLOGY_N_STAGE'

P value = 0.0012 (Fisher's exact test), Q value = 0.012

Table S299.  Gene #65: 'del_17q24.3' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 38(17Q24.3) MUTATED 38 30 27
DEL PEAK 38(17Q24.3) WILD-TYPE 307 120 88

Figure S299.  Get High-res Image Gene #65: 'del_17q24.3' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_17q24.3' versus 'PATHOLOGY_M_STAGE'

P value = 0.0136 (Fisher's exact test), Q value = 0.075

Table S300.  Gene #65: 'del_17q24.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 38(17Q24.3) MUTATED 59 21
DEL PEAK 38(17Q24.3) WILD-TYPE 391 67

Figure S300.  Get High-res Image Gene #65: 'del_17q24.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_17q24.3' versus 'NUMBER_OF_LYMPH_NODES'

P value = 9.25e-05 (Wilcoxon-test), Q value = 0.0017

Table S301.  Gene #65: 'del_17q24.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 38(17Q24.3) MUTATED 90 3.1 (4.5)
DEL PEAK 38(17Q24.3) WILD-TYPE 486 2.1 (4.7)

Figure S301.  Get High-res Image Gene #65: 'del_17q24.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_18p11.31' versus 'YEARS_TO_BIRTH'

P value = 0.0221 (Wilcoxon-test), Q value = 0.11

Table S302.  Gene #66: 'del_18p11.31' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
DEL PEAK 39(18P11.31) MUTATED 368 65.5 (12.0)
DEL PEAK 39(18P11.31) WILD-TYPE 242 67.4 (13.8)

Figure S302.  Get High-res Image Gene #66: 'del_18p11.31' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_18p11.31' versus 'TUMOR_TISSUE_SITE'

P value = 2.63e-06 (Fisher's exact test), Q value = 0.00032

Table S303.  Gene #66: 'del_18p11.31' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 39(18P11.31) MUTATED 243 122
DEL PEAK 39(18P11.31) WILD-TYPE 203 40

Figure S303.  Get High-res Image Gene #66: 'del_18p11.31' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_18p11.31' versus 'PATHOLOGIC_STAGE'

P value = 0.00012 (Fisher's exact test), Q value = 0.002

Table S304.  Gene #66: 'del_18p11.31' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 39(18P11.31) MUTATED 57 0 14 98 4 3 12 12 54 33 48 24 1
DEL PEAK 39(18P11.31) WILD-TYPE 47 1 22 75 6 0 14 6 29 21 15 2 1

Figure S304.  Get High-res Image Gene #66: 'del_18p11.31' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_18p11.31' versus 'PATHOLOGY_N_STAGE'

P value = 0.00898 (Fisher's exact test), Q value = 0.058

Table S305.  Gene #66: 'del_18p11.31' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 39(18P11.31) MUTATED 190 104 73
DEL PEAK 39(18P11.31) WILD-TYPE 155 46 42

Figure S305.  Get High-res Image Gene #66: 'del_18p11.31' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_18p11.31' versus 'PATHOLOGY_M_STAGE'

P value = 7.53e-06 (Fisher's exact test), Q value = 0.00032

Table S306.  Gene #66: 'del_18p11.31' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 39(18P11.31) MUTATED 256 72
DEL PEAK 39(18P11.31) WILD-TYPE 194 16

Figure S306.  Get High-res Image Gene #66: 'del_18p11.31' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_18p11.31' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S307.  Gene #66: 'del_18p11.31' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 39(18P11.31) MUTATED 231 9 116 6
DEL PEAK 39(18P11.31) WILD-TYPE 151 51 30 7

Figure S307.  Get High-res Image Gene #66: 'del_18p11.31' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_18p11.31' versus 'RESIDUAL_TUMOR'

P value = 0.0398 (Fisher's exact test), Q value = 0.16

Table S308.  Gene #66: 'del_18p11.31' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
DEL PEAK 39(18P11.31) MUTATED 263 2 29 14
DEL PEAK 39(18P11.31) WILD-TYPE 179 3 8 15

Figure S308.  Get High-res Image Gene #66: 'del_18p11.31' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'del_18p11.31' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0178 (Wilcoxon-test), Q value = 0.091

Table S309.  Gene #66: 'del_18p11.31' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 39(18P11.31) MUTATED 344 2.3 (4.2)
DEL PEAK 39(18P11.31) WILD-TYPE 232 2.1 (5.3)

Figure S309.  Get High-res Image Gene #66: 'del_18p11.31' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_18q12.2' versus 'YEARS_TO_BIRTH'

P value = 0.0359 (Wilcoxon-test), Q value = 0.15

Table S310.  Gene #67: 'del_18q12.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
DEL PEAK 40(18Q12.2) MUTATED 413 65.7 (12.1)
DEL PEAK 40(18Q12.2) WILD-TYPE 197 67.5 (14.0)

Figure S310.  Get High-res Image Gene #67: 'del_18q12.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_18q12.2' versus 'TUMOR_TISSUE_SITE'

P value = 1.48e-09 (Fisher's exact test), Q value = 1.5e-06

Table S311.  Gene #67: 'del_18q12.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 40(18Q12.2) MUTATED 271 139
DEL PEAK 40(18Q12.2) WILD-TYPE 175 23

Figure S311.  Get High-res Image Gene #67: 'del_18q12.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_18q12.2' versus 'PATHOLOGIC_STAGE'

P value = 4e-04 (Fisher's exact test), Q value = 0.0055

Table S312.  Gene #67: 'del_18q12.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 40(18Q12.2) MUTATED 60 0 21 107 4 3 16 15 61 39 53 23 1
DEL PEAK 40(18Q12.2) WILD-TYPE 44 1 15 66 6 0 10 3 22 15 10 3 1

Figure S312.  Get High-res Image Gene #67: 'del_18q12.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_18q12.2' versus 'PATHOLOGY_N_STAGE'

P value = 0.00013 (Fisher's exact test), Q value = 0.0021

Table S313.  Gene #67: 'del_18q12.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 40(18Q12.2) MUTATED 208 116 87
DEL PEAK 40(18Q12.2) WILD-TYPE 137 34 28

Figure S313.  Get High-res Image Gene #67: 'del_18q12.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_18q12.2' versus 'PATHOLOGY_M_STAGE'

P value = 0.000406 (Fisher's exact test), Q value = 0.0055

Table S314.  Gene #67: 'del_18q12.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 40(18Q12.2) MUTATED 294 74
DEL PEAK 40(18Q12.2) WILD-TYPE 156 14

Figure S314.  Get High-res Image Gene #67: 'del_18q12.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_18q12.2' versus 'RADIATION_THERAPY'

P value = 0.0371 (Fisher's exact test), Q value = 0.15

Table S315.  Gene #67: 'del_18q12.2' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 40(18Q12.2) MUTATED 296 24
DEL PEAK 40(18Q12.2) WILD-TYPE 150 4

Figure S315.  Get High-res Image Gene #67: 'del_18q12.2' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_18q12.2' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S316.  Gene #67: 'del_18q12.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 40(18Q12.2) MUTATED 254 14 128 10
DEL PEAK 40(18Q12.2) WILD-TYPE 128 46 18 3

Figure S316.  Get High-res Image Gene #67: 'del_18q12.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_18q12.2' versus 'RESIDUAL_TUMOR'

P value = 0.0631 (Fisher's exact test), Q value = 0.21

Table S317.  Gene #67: 'del_18q12.2' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
DEL PEAK 40(18Q12.2) MUTATED 296 3 29 14
DEL PEAK 40(18Q12.2) WILD-TYPE 146 2 8 15

Figure S317.  Get High-res Image Gene #67: 'del_18q12.2' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'del_18q12.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000533 (Wilcoxon-test), Q value = 0.0066

Table S318.  Gene #67: 'del_18q12.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 40(18Q12.2) MUTATED 389 2.5 (5.0)
DEL PEAK 40(18Q12.2) WILD-TYPE 187 1.7 (4.0)

Figure S318.  Get High-res Image Gene #67: 'del_18q12.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_18q21.2' versus 'YEARS_TO_BIRTH'

P value = 0.0521 (Wilcoxon-test), Q value = 0.18

Table S319.  Gene #68: 'del_18q21.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 610 66.3 (12.8)
DEL PEAK 41(18Q21.2) MUTATED 430 65.8 (12.1)
DEL PEAK 41(18Q21.2) WILD-TYPE 180 67.5 (14.1)

Figure S319.  Get High-res Image Gene #68: 'del_18q21.2' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'del_18q21.2' versus 'TUMOR_TISSUE_SITE'

P value = 3.63e-09 (Fisher's exact test), Q value = 1.9e-06

Table S320.  Gene #68: 'del_18q21.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 41(18Q21.2) MUTATED 285 142
DEL PEAK 41(18Q21.2) WILD-TYPE 161 20

Figure S320.  Get High-res Image Gene #68: 'del_18q21.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_18q21.2' versus 'PATHOLOGIC_STAGE'

P value = 2e-05 (Fisher's exact test), Q value = 0.00054

Table S321.  Gene #68: 'del_18q21.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 41(18Q21.2) MUTATED 62 0 23 109 4 3 17 15 64 42 56 24 2
DEL PEAK 41(18Q21.2) WILD-TYPE 42 1 13 64 6 0 9 3 19 12 7 2 0

Figure S321.  Get High-res Image Gene #68: 'del_18q21.2' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_18q21.2' versus 'PATHOLOGY_N_STAGE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S322.  Gene #68: 'del_18q21.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 41(18Q21.2) MUTATED 214 120 94
DEL PEAK 41(18Q21.2) WILD-TYPE 131 30 21

Figure S322.  Get High-res Image Gene #68: 'del_18q21.2' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_18q21.2' versus 'PATHOLOGY_M_STAGE'

P value = 9.02e-06 (Fisher's exact test), Q value = 0.00032

Table S323.  Gene #68: 'del_18q21.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 41(18Q21.2) MUTATED 304 79
DEL PEAK 41(18Q21.2) WILD-TYPE 146 9

Figure S323.  Get High-res Image Gene #68: 'del_18q21.2' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_18q21.2' versus 'GENDER'

P value = 0.0631 (Fisher's exact test), Q value = 0.21

Table S324.  Gene #68: 'del_18q21.2' versus Clinical Feature #8: 'GENDER'

nPatients FEMALE MALE
ALL 287 325
DEL PEAK 41(18Q21.2) MUTATED 191 239
DEL PEAK 41(18Q21.2) WILD-TYPE 96 86

Figure S324.  Get High-res Image Gene #68: 'del_18q21.2' versus Clinical Feature #8: 'GENDER'

'del_18q21.2' versus 'RADIATION_THERAPY'

P value = 0.0866 (Fisher's exact test), Q value = 0.25

Table S325.  Gene #68: 'del_18q21.2' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 41(18Q21.2) MUTATED 310 24
DEL PEAK 41(18Q21.2) WILD-TYPE 136 4

Figure S325.  Get High-res Image Gene #68: 'del_18q21.2' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_18q21.2' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S326.  Gene #68: 'del_18q21.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 41(18Q21.2) MUTATED 266 16 129 11
DEL PEAK 41(18Q21.2) WILD-TYPE 116 44 17 2

Figure S326.  Get High-res Image Gene #68: 'del_18q21.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_18q21.2' versus 'RESIDUAL_TUMOR'

P value = 0.064 (Fisher's exact test), Q value = 0.21

Table S327.  Gene #68: 'del_18q21.2' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

nPatients R0 R1 R2 RX
ALL 442 5 37 29
DEL PEAK 41(18Q21.2) MUTATED 306 3 30 15
DEL PEAK 41(18Q21.2) WILD-TYPE 136 2 7 14

Figure S327.  Get High-res Image Gene #68: 'del_18q21.2' versus Clinical Feature #11: 'RESIDUAL_TUMOR'

'del_18q21.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 6.3e-06 (Wilcoxon-test), Q value = 0.00032

Table S328.  Gene #68: 'del_18q21.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 41(18Q21.2) MUTATED 405 2.6 (5.0)
DEL PEAK 41(18Q21.2) WILD-TYPE 171 1.5 (3.9)

Figure S328.  Get High-res Image Gene #68: 'del_18q21.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_18q22.1' versus 'TUMOR_TISSUE_SITE'

P value = 1.68e-07 (Fisher's exact test), Q value = 4.3e-05

Table S329.  Gene #69: 'del_18q22.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 42(18Q22.1) MUTATED 284 138
DEL PEAK 42(18Q22.1) WILD-TYPE 162 24

Figure S329.  Get High-res Image Gene #69: 'del_18q22.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_18q22.1' versus 'PATHOLOGIC_STAGE'

P value = 4e-05 (Fisher's exact test), Q value = 0.00095

Table S330.  Gene #69: 'del_18q22.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 42(18Q22.1) MUTATED 62 0 23 109 4 3 14 15 63 42 55 24 2
DEL PEAK 42(18Q22.1) WILD-TYPE 42 1 13 64 6 0 12 3 20 12 8 2 0

Figure S330.  Get High-res Image Gene #69: 'del_18q22.1' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_18q22.1' versus 'PATHOLOGY_N_STAGE'

P value = 5e-05 (Fisher's exact test), Q value = 0.0011

Table S331.  Gene #69: 'del_18q22.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 42(18Q22.1) MUTATED 214 116 93
DEL PEAK 42(18Q22.1) WILD-TYPE 131 34 22

Figure S331.  Get High-res Image Gene #69: 'del_18q22.1' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_18q22.1' versus 'PATHOLOGY_M_STAGE'

P value = 1.92e-05 (Fisher's exact test), Q value = 0.00054

Table S332.  Gene #69: 'del_18q22.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 42(18Q22.1) MUTATED 301 78
DEL PEAK 42(18Q22.1) WILD-TYPE 149 10

Figure S332.  Get High-res Image Gene #69: 'del_18q22.1' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_18q22.1' versus 'GENDER'

P value = 0.0787 (Fisher's exact test), Q value = 0.23

Table S333.  Gene #69: 'del_18q22.1' versus Clinical Feature #8: 'GENDER'

nPatients FEMALE MALE
ALL 287 325
DEL PEAK 42(18Q22.1) MUTATED 189 236
DEL PEAK 42(18Q22.1) WILD-TYPE 98 89

Figure S333.  Get High-res Image Gene #69: 'del_18q22.1' versus Clinical Feature #8: 'GENDER'

'del_18q22.1' versus 'RADIATION_THERAPY'

P value = 0.0867 (Fisher's exact test), Q value = 0.25

Table S334.  Gene #69: 'del_18q22.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

nPatients NO YES
ALL 446 28
DEL PEAK 42(18Q22.1) MUTATED 308 24
DEL PEAK 42(18Q22.1) WILD-TYPE 138 4

Figure S334.  Get High-res Image Gene #69: 'del_18q22.1' versus Clinical Feature #9: 'RADIATION_THERAPY'

'del_18q22.1' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.00032

Table S335.  Gene #69: 'del_18q22.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 42(18Q22.1) MUTATED 266 15 127 10
DEL PEAK 42(18Q22.1) WILD-TYPE 116 45 19 3

Figure S335.  Get High-res Image Gene #69: 'del_18q22.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_18q22.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 5.17e-05 (Wilcoxon-test), Q value = 0.0011

Table S336.  Gene #69: 'del_18q22.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 42(18Q22.1) MUTATED 402 2.5 (5.0)
DEL PEAK 42(18Q22.1) WILD-TYPE 174 1.5 (3.9)

Figure S336.  Get High-res Image Gene #69: 'del_18q22.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_19p13.3' versus 'TUMOR_TISSUE_SITE'

P value = 0.0583 (Fisher's exact test), Q value = 0.2

Table S337.  Gene #70: 'del_19p13.3' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 43(19P13.3) MUTATED 62 33
DEL PEAK 43(19P13.3) WILD-TYPE 384 129

Figure S337.  Get High-res Image Gene #70: 'del_19p13.3' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_19p13.3' versus 'PATHOLOGIC_STAGE'

P value = 0.00586 (Fisher's exact test), Q value = 0.043

Table S338.  Gene #70: 'del_19p13.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 43(19P13.3) MUTATED 11 0 4 19 0 1 6 4 10 15 15 8 1
DEL PEAK 43(19P13.3) WILD-TYPE 93 1 32 154 10 2 20 14 73 39 48 18 1

Figure S338.  Get High-res Image Gene #70: 'del_19p13.3' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_19p13.3' versus 'PATHOLOGY_N_STAGE'

P value = 5e-05 (Fisher's exact test), Q value = 0.0011

Table S339.  Gene #70: 'del_19p13.3' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 43(19P13.3) MUTATED 36 28 32
DEL PEAK 43(19P13.3) WILD-TYPE 309 122 83

Figure S339.  Get High-res Image Gene #70: 'del_19p13.3' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_19p13.3' versus 'PATHOLOGY_M_STAGE'

P value = 0.00667 (Fisher's exact test), Q value = 0.047

Table S340.  Gene #70: 'del_19p13.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 43(19P13.3) MUTATED 63 23
DEL PEAK 43(19P13.3) WILD-TYPE 387 65

Figure S340.  Get High-res Image Gene #70: 'del_19p13.3' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_19p13.3' versus 'HISTOLOGICAL_TYPE'

P value = 0.0865 (Fisher's exact test), Q value = 0.25

Table S341.  Gene #70: 'del_19p13.3' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 43(19P13.3) MUTATED 56 5 31 1
DEL PEAK 43(19P13.3) WILD-TYPE 326 55 115 12

Figure S341.  Get High-res Image Gene #70: 'del_19p13.3' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_19p13.3' versus 'NUMBER_OF_LYMPH_NODES'

P value = 5.08e-06 (Wilcoxon-test), Q value = 0.00032

Table S342.  Gene #70: 'del_19p13.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 43(19P13.3) MUTATED 90 3.9 (6.0)
DEL PEAK 43(19P13.3) WILD-TYPE 486 1.9 (4.4)

Figure S342.  Get High-res Image Gene #70: 'del_19p13.3' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_20p12.1' versus 'TUMOR_TISSUE_SITE'

P value = 0.00538 (Fisher's exact test), Q value = 0.04

Table S343.  Gene #71: 'del_20p12.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 44(20P12.1) MUTATED 84 48
DEL PEAK 44(20P12.1) WILD-TYPE 362 114

Figure S343.  Get High-res Image Gene #71: 'del_20p12.1' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_20p12.1' versus 'HISTOLOGICAL_TYPE'

P value = 0.0019 (Fisher's exact test), Q value = 0.018

Table S344.  Gene #71: 'del_20p12.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 44(20P12.1) MUTATED 77 5 43 5
DEL PEAK 44(20P12.1) WILD-TYPE 305 55 103 8

Figure S344.  Get High-res Image Gene #71: 'del_20p12.1' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_20p12.1' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0618 (Wilcoxon-test), Q value = 0.21

Table S345.  Gene #71: 'del_20p12.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 44(20P12.1) MUTATED 127 2.7 (5.2)
DEL PEAK 44(20P12.1) WILD-TYPE 449 2.1 (4.6)

Figure S345.  Get High-res Image Gene #71: 'del_20p12.1' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_21q11.2' versus 'TUMOR_TISSUE_SITE'

P value = 0.00374 (Fisher's exact test), Q value = 0.031

Table S346.  Gene #72: 'del_21q11.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

nPatients COLON RECTUM
ALL 446 162
DEL PEAK 45(21Q11.2) MUTATED 138 71
DEL PEAK 45(21Q11.2) WILD-TYPE 308 91

Figure S346.  Get High-res Image Gene #72: 'del_21q11.2' versus Clinical Feature #3: 'TUMOR_TISSUE_SITE'

'del_21q11.2' versus 'HISTOLOGICAL_TYPE'

P value = 5e-05 (Fisher's exact test), Q value = 0.0011

Table S347.  Gene #72: 'del_21q11.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 45(21Q11.2) MUTATED 128 8 66 3
DEL PEAK 45(21Q11.2) WILD-TYPE 254 52 80 10

Figure S347.  Get High-res Image Gene #72: 'del_21q11.2' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_21q11.2' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.0263 (Wilcoxon-test), Q value = 0.12

Table S348.  Gene #72: 'del_21q11.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 45(21Q11.2) MUTATED 201 3.0 (6.2)
DEL PEAK 45(21Q11.2) WILD-TYPE 375 1.8 (3.6)

Figure S348.  Get High-res Image Gene #72: 'del_21q11.2' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

'del_21q11.2' versus 'ETHNICITY'

P value = 0.0535 (Fisher's exact test), Q value = 0.19

Table S349.  Gene #72: 'del_21q11.2' versus Clinical Feature #14: 'ETHNICITY'

nPatients HISPANIC OR LATINO NOT HISPANIC OR LATINO
ALL 5 348
DEL PEAK 45(21Q11.2) MUTATED 4 120
DEL PEAK 45(21Q11.2) WILD-TYPE 1 228

Figure S349.  Get High-res Image Gene #72: 'del_21q11.2' versus Clinical Feature #14: 'ETHNICITY'

'del_22q13.32' versus 'Time to Death'

P value = 0.065 (logrank test), Q value = 0.21

Table S350.  Gene #73: 'del_22q13.32' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 593 121 0.0 - 148.0 (20.0)
DEL PEAK 46(22Q13.32) MUTATED 219 50 0.2 - 140.4 (19.3)
DEL PEAK 46(22Q13.32) WILD-TYPE 374 71 0.0 - 148.0 (20.2)

Figure S350.  Get High-res Image Gene #73: 'del_22q13.32' versus Clinical Feature #1: 'Time to Death'

'del_22q13.32' versus 'PATHOLOGIC_STAGE'

P value = 0.00437 (Fisher's exact test), Q value = 0.035

Table S351.  Gene #73: 'del_22q13.32' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

nPatients STAGE I STAGE IA STAGE II STAGE IIA STAGE IIB STAGE IIC STAGE III STAGE IIIA STAGE IIIB STAGE IIIC STAGE IV STAGE IVA STAGE IVB
ALL 104 1 36 173 10 3 26 18 83 54 63 26 2
DEL PEAK 46(22Q13.32) MUTATED 29 0 9 59 1 1 10 12 31 24 34 11 0
DEL PEAK 46(22Q13.32) WILD-TYPE 75 1 27 114 9 2 16 6 52 30 29 15 2

Figure S351.  Get High-res Image Gene #73: 'del_22q13.32' versus Clinical Feature #4: 'PATHOLOGIC_STAGE'

'del_22q13.32' versus 'PATHOLOGY_N_STAGE'

P value = 0.00032 (Fisher's exact test), Q value = 0.0047

Table S352.  Gene #73: 'del_22q13.32' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

nPatients N0 N1 N2
ALL 345 150 115
DEL PEAK 46(22Q13.32) MUTATED 104 71 51
DEL PEAK 46(22Q13.32) WILD-TYPE 241 79 64

Figure S352.  Get High-res Image Gene #73: 'del_22q13.32' versus Clinical Feature #6: 'PATHOLOGY_N_STAGE'

'del_22q13.32' versus 'PATHOLOGY_M_STAGE'

P value = 0.00756 (Fisher's exact test), Q value = 0.051

Table S353.  Gene #73: 'del_22q13.32' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

nPatients 0 1
ALL 450 88
DEL PEAK 46(22Q13.32) MUTATED 154 44
DEL PEAK 46(22Q13.32) WILD-TYPE 296 44

Figure S353.  Get High-res Image Gene #73: 'del_22q13.32' versus Clinical Feature #7: 'PATHOLOGY_M_STAGE'

'del_22q13.32' versus 'HISTOLOGICAL_TYPE'

P value = 0.00664 (Fisher's exact test), Q value = 0.047

Table S354.  Gene #73: 'del_22q13.32' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

nPatients COLON ADENOCARCINOMA COLON MUCINOUS ADENOCARCINOMA RECTAL ADENOCARCINOMA RECTAL MUCINOUS ADENOCARCINOMA
ALL 382 60 146 13
DEL PEAK 46(22Q13.32) MUTATED 146 11 62 4
DEL PEAK 46(22Q13.32) WILD-TYPE 236 49 84 9

Figure S354.  Get High-res Image Gene #73: 'del_22q13.32' versus Clinical Feature #10: 'HISTOLOGICAL_TYPE'

'del_22q13.32' versus 'NUMBER_OF_LYMPH_NODES'

P value = 0.000389 (Wilcoxon-test), Q value = 0.0054

Table S355.  Gene #73: 'del_22q13.32' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

nPatients Mean (Std.Dev)
ALL 576 2.2 (4.7)
DEL PEAK 46(22Q13.32) MUTATED 214 2.9 (5.1)
DEL PEAK 46(22Q13.32) WILD-TYPE 362 1.9 (4.4)

Figure S355.  Get High-res Image Gene #73: 'del_22q13.32' versus Clinical Feature #12: 'NUMBER_OF_LYMPH_NODES'

Methods & Data
Input

  • Copy number data file = all_lesions.txt from GISTIC pipeline

  • Processed Copy number data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/COADREAD-TP/19781253/transformed.cor.cli.txt

  • Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/COADREAD-TP/19775152/COADREAD-TP.merged_data.txt

  • Number of patients = 612

  • Number of significantly focal cnvs = 73

  • Number of selected clinical features = 14

  • Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
Copyright © 2015 Broad Institute TCGA GDAC as part of the TCGA Research Network. All rights reserved.
Made with Nozzle