E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.022 0.031 -9999.0 0.0 -0.308 2.0 2.0 KLHL20 0.041 0.07 0.205 29.0 -0.239 8.0 37.0 CYFIP2 0.027 0.016 -9999.0 0.0 -0.36 1.0 1.0 Rac1/GDP 0.071 0.08 0.287 8.0 -9999.0 0.0 8.0 ENAH 0.022 0.032 -9999.0 0.0 -0.308 2.0 2.0 AP1M1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.017 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.007 0.025 -9999.0 0.0 -0.164 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.052 0.05 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.06 0.083 0.294 10.0 -9999.0 0.0 10.0 CTNND1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.03 0.033 -9999.0 0.0 -0.315 2.0 2.0 CRK 0.06 0.078 -9999.0 0.0 -0.3 1.0 1.0 E-cadherin/gamma catenin/alpha catenin 0.053 0.016 -9999.0 0.0 -0.212 1.0 1.0 alphaE/beta7 Integrin 0.024 0.054 -9999.0 0.0 -0.24 23.0 23.0 IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.051 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.022 0.032 -9999.0 0.0 -0.308 2.0 2.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.004 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.021 0.077 -9999.0 0.0 -0.197 64.0 64.0 PI3K 0.008 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.04 0.014 -9999.0 0.0 -0.252 1.0 1.0 TIAM1 -0.011 0.114 -9999.0 0.0 -0.36 59.0 59.0 E-cadherin(dimer)/Ca2+ 0.063 0.016 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.025 0.045 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.084 0.083 0.303 12.0 -9999.0 0.0 12.0 actin cytoskeleton organization 0.039 0.058 0.171 34.0 -0.174 8.0 42.0 CDC42/GDP 0.08 0.083 0.303 12.0 -9999.0 0.0 12.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.02 0.01 -9999.0 0.0 -0.193 1.0 1.0 ITGB7 0.013 0.074 -9999.0 0.0 -0.36 23.0 23.0 RAC1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.068 0.017 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.048 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.076 0.09 0.312 13.0 -9999.0 0.0 13.0 CDC42/GTP/IQGAP1 0.033 0.015 -9999.0 0.0 -0.21 1.0 1.0 JUP 0.027 0.016 -9999.0 0.0 -0.36 1.0 1.0 p120 catenin/RhoA/GDP 0.093 0.082 0.306 12.0 -9999.0 0.0 12.0 RAC1/GTP/IQGAP1 0.033 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.013 -9999.0 0.0 -0.252 1.0 1.0 RHOA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.017 -9999.0 0.0 -0.36 1.0 1.0 CTNNA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.033 0.048 0.144 41.0 -0.165 5.0 46.0 NME1 0.022 0.057 0.355 2.0 -0.442 8.0 10.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.021 0.031 -9999.0 0.0 -0.308 2.0 2.0 regulation of cell-cell adhesion 0.011 0.016 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.015 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.081 0.072 0.306 5.0 -9999.0 0.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.053 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.038 0.055 0.163 39.0 -0.203 5.0 44.0 VAV2 0.077 0.126 0.412 1.0 -0.621 10.0 11.0 RAP1/GDP 0.091 0.079 0.307 10.0 -9999.0 0.0 10.0 adherens junction assembly 0.021 0.031 -9999.0 0.0 -0.3 2.0 2.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.016 -9999.0 0.0 -0.36 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.046 0.047 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.014 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.013 0.027 -9999.0 0.0 -0.308 2.0 2.0 PIK3CA 0.027 0.016 -9999.0 0.0 -0.36 1.0 1.0 Rac1/GTP -0.002 0.061 -9999.0 0.0 -0.378 9.0 9.0 E-cadherin/beta catenin/alpha catenin 0.054 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.031 0.033 -9999.0 0.0 -0.32 2.0 2.0