Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.027 0.067 0.3 23.0 -0.235 2.0 25.0 KIRREL 0.021 0.048 -9999.0 0.0 -0.376 8.0 8.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.027 0.067 0.235 2.0 -0.3 23.0 25.0 PLCG1 0.016 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.043 0.079 -9999.0 0.0 -0.237 37.0 37.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.02 0.037 0.204 2.0 -0.222 7.0 9.0 FYN 0.01 0.063 0.282 12.0 -0.207 25.0 37.0 mol:Ca2+ 0.027 0.061 0.221 1.0 -0.236 21.0 22.0 mol:DAG 0.027 0.062 0.225 1.0 -0.237 21.0 22.0 NPHS2 0.013 0.049 -9999.0 0.0 -0.446 6.0 6.0 mol:IP3 0.027 0.062 0.225 1.0 -0.237 21.0 22.0 regulation of endocytosis 0.036 0.054 0.209 2.0 -0.203 18.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.035 0.059 0.21 2.0 -0.234 25.0 27.0 establishment of cell polarity 0.027 0.067 0.235 2.0 -0.3 23.0 25.0 Nephrin/NEPH1/podocin/NCK1-2 0.064 0.063 -9999.0 0.0 -0.387 2.0 2.0 Nephrin/NEPH1/beta Arrestin2 0.037 0.056 0.217 2.0 -0.205 18.0 20.0 NPHS1 0.013 0.076 0.323 2.0 -0.444 15.0 17.0 Nephrin/NEPH1/podocin 0.037 0.054 0.213 2.0 -0.208 25.0 27.0 TJP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.028 0.062 0.229 1.0 -0.238 21.0 22.0 CD2AP 0.016 0.066 -9999.0 0.0 -0.36 18.0 18.0 Nephrin/NEPH1/podocin/GRB2 0.05 0.064 0.229 2.0 -0.237 25.0 27.0 GRB2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.011 0.076 0.295 12.0 -0.214 43.0 55.0 cytoskeleton organization 0.009 0.046 0.204 7.0 -0.346 2.0 9.0 Nephrin/NEPH1 0.025 0.048 0.192 2.0 -0.205 23.0 25.0 Nephrin/NEPH1/ZO-1 0.04 0.059 0.224 2.0 -0.238 22.0 24.0