Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.014 0.099 -9999.0 0.0 -0.47 14.0 14.0 IHH 0.021 0.077 -9999.0 0.0 -0.42 16.0 16.0 SHH Np/Cholesterol/GAS1 -0.054 0.131 0.185 4.0 -0.246 180.0 184.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.054 0.13 0.245 180.0 -0.183 4.0 184.0 SMO/beta Arrestin2 0.018 0.089 -9999.0 0.0 -0.435 9.0 9.0 SMO 0.004 0.083 -9999.0 0.0 -0.457 9.0 9.0 AKT1 -0.0 0.108 -9999.0 0.0 -0.349 39.0 39.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.011 0.078 -9999.0 0.0 -0.36 26.0 26.0 ADRBK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.006 0.083 -9999.0 0.0 -0.45 9.0 9.0 STIL -0.022 0.112 0.34 1.0 -0.376 10.0 11.0 DHH N/PTCH2 0.027 0.061 -9999.0 0.0 -0.262 26.0 26.0 DHH N/PTCH1 0.024 0.086 -9999.0 0.0 -0.439 8.0 8.0 PIK3CA 0.027 0.016 -9999.0 0.0 -0.36 1.0 1.0 DHH 0.011 0.073 -9999.0 0.0 -0.36 22.0 22.0 PTHLH 0.006 0.13 -9999.0 0.0 -0.731 14.0 14.0 determination of left/right symmetry 0.006 0.083 -9999.0 0.0 -0.45 9.0 9.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.007 0.129 -9999.0 0.0 -0.723 14.0 14.0 IHH N/Hhip -0.022 0.134 -9999.0 0.0 -0.29 117.0 117.0 DHH N/Hhip -0.022 0.126 -9999.0 0.0 -0.271 120.0 120.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.006 0.083 -9999.0 0.0 -0.45 9.0 9.0 pancreas development -0.043 0.148 -9999.0 0.0 -0.36 109.0 109.0 HHAT 0.024 0.035 -9999.0 0.0 -0.36 5.0 5.0 PI3K 0.039 0.015 -9999.0 0.0 -0.252 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.035 0.143 -9999.0 0.0 -0.364 97.0 97.0 somite specification 0.006 0.083 -9999.0 0.0 -0.45 9.0 9.0 SHH Np/Cholesterol/PTCH1 -0.023 0.111 -9999.0 0.0 -0.371 12.0 12.0 SHH Np/Cholesterol/PTCH2 -0.026 0.108 0.185 5.0 -0.239 123.0 128.0 SHH Np/Cholesterol/Megalin -0.048 0.13 0.179 5.0 -0.261 158.0 163.0 SHH -0.048 0.135 0.315 6.0 -0.315 118.0 124.0 catabolic process 0.019 0.077 -9999.0 0.0 -0.382 13.0 13.0 SMO/Vitamin D3 -0.019 0.111 -9999.0 0.0 -0.396 13.0 13.0 SHH Np/Cholesterol/Hhip -0.059 0.126 0.185 5.0 -0.231 204.0 209.0 LRP2 -0.036 0.131 -9999.0 0.0 -0.443 56.0 56.0 receptor-mediated endocytosis -0.032 0.116 0.233 3.0 -0.408 18.0 21.0 SHH Np/Cholesterol/BOC -0.032 0.112 0.185 4.0 -0.237 138.0 142.0 SHH Np/Cholesterol/CDO -0.025 0.107 0.185 4.0 -0.24 119.0 123.0 mesenchymal cell differentiation 0.059 0.126 0.23 204.0 -0.183 5.0 209.0 mol:Vitamin D3 -0.017 0.12 0.356 1.0 -0.373 12.0 13.0 IHH N/PTCH2 0.031 0.059 -9999.0 0.0 -0.266 20.0 20.0 CDON 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.027 0.08 -9999.0 0.0 -0.385 13.0 13.0 Megalin/LRPAP1 0.004 0.102 -9999.0 0.0 -0.317 56.0 56.0 PTCH2 0.024 0.038 -9999.0 0.0 -0.443 4.0 4.0 SHH Np/Cholesterol -0.034 0.1 -9999.0 0.0 -0.238 119.0 119.0 PTCH1 0.019 0.077 -9999.0 0.0 -0.383 13.0 13.0 HHIP -0.043 0.148 -9999.0 0.0 -0.36 109.0 109.0