Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.008 0.157 -9999.0 0.0 -0.662 9.0 9.0 IHH 0.023 0.102 -9999.0 0.0 -0.388 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.073 0.137 -9999.0 0.0 -0.298 48.0 48.0 LRPAP1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.072 0.136 0.296 48.0 -9999.0 0.0 48.0 SMO/beta Arrestin2 0.001 0.157 -9999.0 0.0 -0.57 9.0 9.0 SMO -0.013 0.156 -9999.0 0.0 -0.534 12.0 12.0 AKT1 -0.014 0.16 -9999.0 0.0 -0.604 8.0 8.0 ARRB2 0.027 0.037 -9999.0 0.0 -0.469 1.0 1.0 BOC 0.028 0.051 -9999.0 0.0 -0.231 7.0 7.0 ADRBK1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.012 0.153 -9999.0 0.0 -0.524 12.0 12.0 STIL -0.009 0.127 0.365 1.0 -0.384 11.0 12.0 DHH N/PTCH2 0.053 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.032 0.12 -9999.0 0.0 -0.399 12.0 12.0 PIK3CA 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.005 0.206 -9999.0 0.0 -0.915 9.0 9.0 determination of left/right symmetry -0.012 0.153 -9999.0 0.0 -0.524 12.0 12.0 PIK3R1 0.029 0.06 -9999.0 0.0 -0.469 3.0 3.0 skeletal system development -0.005 0.203 -9999.0 0.0 -0.902 9.0 9.0 IHH N/Hhip -0.015 0.161 -9999.0 0.0 -0.397 29.0 29.0 DHH N/Hhip -0.004 0.13 -9999.0 0.0 -0.338 26.0 26.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.012 0.153 -9999.0 0.0 -0.524 12.0 12.0 pancreas development -0.036 0.168 -9999.0 0.0 -0.386 37.0 37.0 HHAT -0.001 0.125 -9999.0 0.0 -0.381 19.0 19.0 PI3K 0.047 0.047 -9999.0 0.0 -0.338 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.116 0.197 -9999.0 0.0 -0.318 92.0 92.0 somite specification -0.012 0.153 -9999.0 0.0 -0.524 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.002 0.123 -9999.0 0.0 -0.42 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.01 0.078 -9999.0 0.0 -0.264 14.0 14.0 SHH Np/Cholesterol/Megalin 0.009 0.079 -9999.0 0.0 -0.265 14.0 14.0 SHH -0.011 0.093 -9999.0 0.0 -0.345 14.0 14.0 catabolic process 0.014 0.126 -9999.0 0.0 -0.427 13.0 13.0 SMO/Vitamin D3 -0.013 0.144 -9999.0 0.0 -0.523 9.0 9.0 SHH Np/Cholesterol/Hhip -0.03 0.127 -9999.0 0.0 -0.295 35.0 35.0 LRP2 0.035 0.022 -9999.0 0.0 -0.191 2.0 2.0 receptor-mediated endocytosis -0.017 0.143 -9999.0 0.0 -0.519 9.0 9.0 SHH Np/Cholesterol/BOC 0.006 0.08 -9999.0 0.0 -0.266 14.0 14.0 SHH Np/Cholesterol/CDO 0.009 0.079 -9999.0 0.0 -0.265 14.0 14.0 mesenchymal cell differentiation 0.03 0.126 0.294 35.0 -9999.0 0.0 35.0 mol:Vitamin D3 0.004 0.131 0.387 1.0 -0.422 9.0 10.0 IHH N/PTCH2 0.043 0.068 -9999.0 0.0 -0.343 5.0 5.0 CDON 0.034 0.023 -9999.0 0.0 -0.191 2.0 2.0 IHH N/PTCH1 0.026 0.13 -9999.0 0.0 -0.43 13.0 13.0 Megalin/LRPAP1 0.051 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.003 0.073 -9999.0 0.0 -0.264 14.0 14.0 PTCH1 0.014 0.126 -9999.0 0.0 -0.429 13.0 13.0 HHIP -0.037 0.168 -9999.0 0.0 -0.387 37.0 37.0