Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
MYD88	3 (7%)	38	0.24268	1	0.23171	1	1	1	0.76588	1	0.42857	1	NA	NA	0.3823	1	0.64571	1	0.59286	1	0.36299	1
FRG1	9 (22%)	32	0.7061	1	0.71859	1	0.38985	1	0.84907	1	1	1	0.35898	1	0.27039	1	0.061689	1	1	1	0.0367	1
MLL2	14 (34%)	27	0.096944	1	0.32642	1	1	1	1	1	0.64241	1	0.10018	1	0.33653	1	0.19898	1	0.50179	1	0.20265	1
TPPP	5 (12%)	36	1	1	0.18361	1	0.5977	1	0.76527	1	0.60301	1	0.3015	1	0.68907	1	0.72696	1	1	1	0.65147	1
CHIT1	6 (15%)	35	1	1	1	1	0.65134	1	0.44664	1	0.48571	1	NA	NA	0.43203	1	0.82702	1	0.16721	1	0.92891	1
B2M	8 (20%)	33	0.059434	1	0.69652	1	0.38985	1	0.84988	1	1	1	0.39253	1	0.12027	1	0.90627	1	0.40799	1	0.3978	1
TPTE2	11 (27%)	30	1	1	1	1	0.16858	1	0.4478	1	0.65944	1	0.46967	1	0.1788	1	0.65223	1	0.69515	1	0.35073	1
RHPN2	6 (15%)	35	0.6786	1	1	1	0.099617	1	0.076629	1	1	1	0.28886	1	0.53298	1	0.18097	1	0.66171	1	0.01053	1
FOXD4L1	7 (17%)	34	0.43755	1	0.69652	1	1	1	0.2659	1	1	1	0.23269	1	0.94566	1	0.96616	1	0.18213	1	0.49837	1
DND1	5 (12%)	36	0.63843	1	1	1	1	1	0.37457	1	1	1	0.23205	1	0.51919	1	0.95948	1	0.60519	1	0.23166	1
ATXN1	7 (17%)	34	1	1	0.69652	1	0.5977	1	0.48745	1	1	1	1	1	0.24794	1	0.23364	1	0.40799	1	0.53414	1
TP53	6 (15%)	35	0.070407	1	0.6628	1	1	1	0.7653	1	0.17143	1	NA	NA	0.21578	1	0.32945	1	1	1	0.9429	1
CDC27	10 (24%)	31	1	1	0.48408	1	1	1	0.62335	1	1	1	0.85553	1	0.39039	1	0.044	1	0.065229	1	0.26527	1
EPB41L4A	4 (10%)	37	0.61776	1	0.34334	1	0.5977	1	0.76498	1	0.48571	1	NA	NA	0.61131	1	0.6119	1	0.60519	1	0.98292	1
NOTCH2NL	4 (10%)	37	1	1	0.34334	1	0.48276	1	NA	NA	1	1	NA	NA	0.89149	1	0.89602	1	0.60519	1	0.11285	1
KRT3	4 (10%)	37	1	1	1	1	0.22414	1	NA	NA	0.48571	1	NA	NA	0.89112	1	0.89507	1	1	1	0.32461	1
OR1S2	10 (24%)	31	0.46731	1	1	1	0.65134	1	0.59914	1	0.61079	1	0.6708	1	0.64311	1	0.695	1	0.43385	1	0.7402	1
RGPD5	5 (12%)	36	0.056335	1	0.18361	1	1	1	0.26577	1	1	1	NA	NA	0.85271	1	0.61106	1	1	1	0.14054	1
TNFAIP3	6 (15%)	35	0.026579	1	1	1	0.65134	1	0.81919	1	0.48571	1	NA	NA	0.32714	1	0.52297	1	0.34199	1	0.02316	1
RBMXL1	4 (10%)	37	1	1	0.34334	1	1	1	1	1	1	1	NA	NA	0.89344	1	0.40713	1	1	1	0.56049	1
CCDC66	4 (10%)	37	1	1	0.047842	1	0.22414	1	NA	NA	0.10376	1	0.055259	1	0.10217	1	0.11149	1	0.23095	1	0.2099	1
NOTCH2	7 (17%)	34	0.43755	1	1	1	1	1	1	1	0.33835	1	0.18269	1	0.80842	1	0.83988	1	0.66171	1	0.27566	1
PCMTD1	6 (15%)	35	1	1	1	1	0.65134	1	0.55064	1	1	1	0.28819	1	0.43016	1	0.32906	1	0.66171	1	0.57494	1
FAM120B	5 (12%)	36	1	1	1	1	0.22414	1	0.26437	1	1	1	1	1	0.41111	1	0.084789	1	0.32554	1	0.77245	1
SMARCA2	4 (10%)	37	1	1	0.34334	1	0.22414	1	NA	NA	0.60301	1	0.50433	1	0.22471	1	0.32826	1	0.1062	1	0.82775	1
C11ORF40	4 (10%)	37	1	1	1	1	1	1	NA	NA	1	1	NA	NA	0.77323	1	0.94614	1	0.59286	1	0.12149	1
ZSCAN5A	3 (7%)	38	0.5728	1	0.10694	1	NA	NA	NA	NA	0.48571	1	NA	NA	0.38138	1	0.77047	1	0.23095	1	0.51155	1
KRTAP4-5	4 (10%)	37	1	1	0.34334	1	1	1	NA	NA	1	1	0.23135	1	0.42549	1	0.47417	1	0.60519	1	0.04791	1
DEFA1	4 (10%)	37	1	1	1	1	1	1	NA	NA	0.22857	1	0.14952	1	0.38204	1	0.25431	1	0.1062	1	0.3271	1
SIRPA	5 (12%)	36	1	1	0.6628	1	0.5977	1	0.76557	1	0.33835	1	0.45503	1	0.52347	1	0.12128	1	0.34199	1	0.083029	1
TMPRSS13	3 (7%)	38	0.5728	1	0.606	1	1	1	NA	NA	1	1	0.76422	1	0.15871	1	0.01136	1	1	1	0.51133	1
CYP2A6	4 (10%)	37	0.30298	1	1	1	1	1	NA	NA	1	1	0.76232	1	0.01732	1	0.078409	1	0.60519	1	0.19128	1
AR	7 (17%)	34	1	1	0.69652	1	0.099617	1	0.078119	1	0.33835	1	0.81577	1	0.3197	1	0.84052	1	0.66171	1	0.04374	1
ARHGEF5	3 (7%)	38	1	1	1	1	1	1	NA	NA	1	1	0.43233	1	0.88709	1	0.77155	1	0.4873	1	NA	NA
RNF39	3 (7%)	38	0.5728	1	0.606	1	0.48276	1	NA	NA	1	1	0.7635	1	0.8868	1	0.43488	1	1	1	0.21229	1
ABCA1	5 (12%)	36	0.63843	1	0.6628	1	1	1	NA	NA	1	1	0.22986	1	1	1	0.88392	1	1	1	0.42274	1
CS	3 (7%)	38	1	1	0.10694	1	0.48276	1	NA	NA	1	1	NA	NA	0.38135	1	0.33251	1	0.23095	1	0.087679	1
IFITM3	4 (10%)	37	0.61776	1	1	1	0.22414	1	0.26794	1	0.60301	1	0.63115	1	0.42917	1	0.071689	1	0.60519	1	0.0146	1
RANBP2	6 (15%)	35	1	1	1	1	0.65134	1	1	1	0.22857	1	0.14907	1	0.83071	1	0.42773	1	0.66171	1	0.57378	1
KLHL6	6 (15%)	35	0.37729	1	1	1	0.3295	1	0.35909	1	0.33835	1	0.81197	1	0.8309	1	0.35141	1	0.34199	1	0.56459	1
ZNF814	10 (24%)	31	0.14224	1	0.48408	1	0.65134	1	0.51314	1	0.22857	1	0.7611	1	0.050579	1	0.01935	1	0.69515	1	0.01225	1
CYP4A11	4 (10%)	37	0.61776	1	1	1	0.22414	1	0.26658	1	1	1	1	1	0.77322	1	0.20333	1	0.32554	1	0.19111	1
PIM1	8 (20%)	33	1	1	0.0034481	1	0.65134	1	1	1	0.17143	1	NA	NA	0.099479	1	0.074499	1	0.036535	1	0.4742	1
POTEE	7 (17%)	34	1	1	1	1	0.042146	1	0.11999	1	1	1	0.12349	1	0.063149	1	0.00183	1	1	1	0.03751	1
OR52E6	3 (7%)	38	0.5728	1	0.606	1	1	1	NA	NA	1	1	0.42934	1	0.88477	1	0.43478	1	1	1	0.21187	1
NBPF10	9 (22%)	32	0.47098	1	0.13001	1	0.65134	1	0.34409	1	1	1	0.23228	1	0.38816	1	0.21229	1	0.43385	1	0.98613	1
PRB2	9 (22%)	32	0.47098	1	1	1	0.38985	1	0.70054	1	0.10376	1	0.054149	1	0.16274	1	0.02342	1	0.40799	1	0.47491	1
MUC6	21 (51%)	20	0.5359	1	0.75786	1	1	1	0.1729	1	0.39643	1	0.15725	1	0.78742	1	0.887	1	0.31612	1	0.93378	1
SALL1	5 (12%)	36	1	1	0.6628	1	0.5977	1	1	1	1	1	NA	NA	1	1	0.21823	1	1	1	0.32508	1
PAK2	7 (17%)	34	0.11213	1	1	1	0.5977	1	1	1	1	1	0.67087	1	0.32407	1	0.44153	1	0.18213	1	0.086649	1
FLG	17 (41%)	24	0.75981	1	1	1	0.71038	1	1	1	1	1	0.04937	1	1	1	0.56297	1	1	1	0.01863	1
MUC17	13 (32%)	28	0.17905	1	0.18094	1	0.68166	1	0.35196	1	1	1	0.85534	1	0.61617	1	0.57095	1	0.48263	1	0.38981	1
OR2T4	8 (20%)	33	0.059434	1	0.13001	1	0.65134	1	0.21676	1	0.10376	1	0.30143	1	0.01019	1	0.17885	1	0.2357	1	0.0078899	1
AMAC1L3	5 (12%)	36	1	1	0.6628	1	0.099617	1	0.26449	1	0.61079	1	0.28568	1	0.31363	1	0.01894	1	0.65043	1	0.065359	1
APOB	3 (7%)	38	1	1	0.10694	1	1	1	NA	NA	0.48571	1	NA	NA	0.15724	1	0.77252	1	0.23095	1	0.21206	1
KRTAP4-7	8 (20%)	33	0.059434	1	1	1	0.68166	1	0.38211	1	0.045113	1	0.45332	1	0.77035	1	0.23273	1	0.2357	1	0.27081	1
MUC16	13 (32%)	28	0.32097	1	0.18094	1	0.42699	1	0.18154	1	0.67307	1	1	1	0.88281	1	0.68181	1	0.48103	1	0.46774	1
NEFH	6 (15%)	35	0.20511	1	0.6628	1	0.042146	1	0.091019	1	1	1	0.29645	1	0.93863	1	0.61332	1	0.39108	1	0.092059	1
KCNN3	7 (17%)	34	0.20855	1	1	1	0.21476	1	0.62116	1	1	1	0.81442	1	0.94592	1	0.36641	1	1	1	0.39022	1
RNASEH2B	3 (7%)	38	0.5728	1	0.606	1	1	1	NA	NA	NA	NA	NA	NA	0.01846	1	0.47306	1	0.59286	1	0.27376	1
FAM153B	3 (7%)	38	1	1	1	1	1	1	0.37385	1	1	1	NA	NA	1	1	1	1	0.59286	1	0.73501	1
OTOP1	4 (10%)	37	0.30298	1	1	1	0.5977	1	0.76541	1	1	1	0.7642	1	0.30435	1	0.47515	1	1	1	0.71252	1
AATK	3 (7%)	38	0.5728	1	1	1	0.48276	1	NA	NA	1	1	0.43144	1	0.8884	1	0.43625	1	1	1	0.087589	1
ARID1A	5 (12%)	36	1	1	0.6628	1	1	1	NA	NA	1	1	0.23051	1	0.52455	1	0.72724	1	0.1062	1	0.02859	1
GUCA1C	3 (7%)	38	0.5728	1	0.606	1	1	1	NA	NA	1	1	0.42955	1	0.88758	1	0.43835	1	1	1	0.21028	1
TRIM48	8 (20%)	33	1	1	1	1	0.68166	1	0.38256	1	0.22857	1	0.14904	1	0.87308	1	1	1	1	1	0.34525	1
CSGALNACT2	5 (12%)	36	1	1	1	1	0.22414	1	0.2681	1	1	1	0.54511	1	0.52259	1	0.12162	1	0.34199	1	0.083539	1
CRIPAK	6 (15%)	35	0.6786	1	0.0086203	1	0.22414	1	NA	NA	0.1778	1	0.58174	1	0.02721	1	0.072629	1	0.020283	1	0.25694	1
DHRS4	4 (10%)	37	1	1	0.047842	1	0.22414	1	NA	NA	0.10376	1	0.055469	1	0.10251	1	0.11206	1	0.23095	1	0.21199	1
FAM21A	4 (10%)	37	0.61776	1	0.34334	1	0.48276	1	NA	NA	0.22857	1	0.43234	1	0.61305	1	0.61064	1	0.1062	1	0.42092	1
KIAA1529	4 (10%)	37	0.61776	1	1	1	1	1	NA	NA	1	1	0.4305	1	1	1	0.75904	1	1	1	0.26824	1
OR2M5	4 (10%)	37	0.61776	1	0.606	1	0.22414	1	0.066469	1	0.063158	1	0.29455	1	0.10243	1	0.22834	1	0.095238	1	0.26765	1
KRT6A	4 (10%)	37	0.30298	1	0.606	1	1	1	1	1	1	1	0.43155	1	1	1	0.89449	1	0.59286	1	1	1
CYP2F1	4 (10%)	37	1	1	0.34334	1	0.22414	1	NA	NA	0.22857	1	0.14898	1	0.22701	1	0.052679	1	0.1062	1	0.19081	1
FCGBP	5 (12%)	36	0.63843	1	0.18361	1	1	1	NA	NA	0.60301	1	0.22974	1	1	1	0.81607	1	1	1	0.59793	1
ZNF493	4 (10%)	37	0.61776	1	1	1	1	1	NA	NA	1	1	0.43223	1	1	1	0.68257	1	1	1	0.27041	1
HLA-B	7 (17%)	34	0.43755	1	0.69652	1	0.3295	1	0.12013	1	0.60301	1	0.63203	1	0.94586	1	0.66449	1	1	1	0.03961	1
FCRLA	3 (7%)	38	1	1	0.606	1	NA	NA	NA	NA	1	1	0.43209	1	0.88619	1	0.77051	1	0.4873	1	NA	NA
KLRC2	5 (12%)	36	1	1	0.6628	1	0.5977	1	0.76342	1	0.33835	1	0.81533	1	0.52384	1	0.24734	1	0.1062	1	0.82865	1
CD79B	5 (12%)	36	0.63843	1	0.34334	1	0.099617	1	0.11445	1	1	1	NA	NA	0.68978	1	0.63535	1	0.59286	1	0.36204	1
TMSB4X	5 (12%)	36	0.36294	1	0.18361	1	0.65134	1	0.55717	1	1	1	0.57174	1	0.3168	1	0.46836	1	0.34199	1	0.6994	1
PRB1	5 (12%)	36	0.36294	1	0.020689	1	1	1	NA	NA	0.22857	1	0.15223	1	0.081119	1	0.70186	1	0.047258	1	0.34473	1
PCDHA7	4 (10%)	37	0.30298	1	0.606	1	0.5977	1	1	1	0.021053	1	0.0069099	1	0.10342	1	0.04773	1	0.32554	1	0.71497	1
OR5H14	3 (7%)	38	0.5728	1	1	1	1	1	1	1	0.42857	1	NA	NA	0.38235	1	0.64644	1	0.59286	1	0.65078	1
PER3	4 (10%)	37	0.11766	1	1	1	1	1	NA	NA	1	1	NA	NA	1	1	0.49849	1	0.4873	1	NA	NA
PABPC1	7 (17%)	34	0.6786	1	1	1	1	1	0.82019	1	0.33835	1	0.45035	1	0.67113	1	0.36224	1	0.68426	1	0.088409	1
ITGA6	3 (7%)	38	1	1	0.606	1	1	1	NA	NA	0.48571	1	NA	NA	0.78427	1	0.7697	1	1	1	0.26892	1
IGSF3	6 (15%)	35	0.6786	1	1	1	1	1	0.21629	1	0.27218	1	0.1197	1	0.69058	1	0.7691	1	1	1	0.78752	1
KRTAP1-1	3 (7%)	38	1	1	0.606	1	1	1	NA	NA	1	1	0.76527	1	0.15987	1	0.33127	1	1	1	0.10275	1
C15ORF39	3 (7%)	38	0.5728	1	0.606	1	0.48276	1	NA	NA	1	1	0.76287	1	0.88652	1	0.43843	1	1	1	0.21056	1
FBXO34	3 (7%)	38	0.5728	1	1	1	0.48276	1	NA	NA	1	1	NA	NA	0.60028	1	0.19026	1	0.59286	1	0.088889	1
ZNF880	8 (20%)	33	1	1	0.13001	1	1	1	0.81906	1	0.65944	1	1	1	0.47416	1	0.23612	1	0.04382	1	0.10527	1
NBPF15	4 (10%)	37	1	1	1	1	1	1	1	1	0.60301	1	0.79019	1	0.77171	1	0.33092	1	0.60519	1	0.82636	1
SLC22A16	3 (7%)	38	1	1	0.606	1	NA	NA	NA	NA	1	1	0.43226	1	0.88693	1	0.77039	1	0.4873	1	NA	NA