rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 51556 2 2 2 0 1 0 0 1 0 0 0.590 0.0885 1.000 2 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNGT1(1), HTR2C(1), PLCB1(8), TUB(2) 517190 12 9 10 7 2 1 0 3 6 0 0.904 0.216 1.000 3 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1), CD3G(2) 84242 3 3 3 3 0 1 0 1 1 0 0.943 0.586 1.000 4 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(2), AOC3(4), CES1(12), ESD(2) 444881 20 8 13 5 6 9 0 2 3 0 0.210 0.618 1.000 5 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(2) 330026 3 3 2 1 0 0 2 1 0 0 0.645 0.659 1.000 6 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), EIF2S2(1), NFKB1(3), NFKBIA(3), TP53(6) 751321 14 13 13 6 4 4 0 1 5 0 0.735 0.742 1.000 7 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOB(1), ALDOC(1) 284076 2 2 2 0 1 1 0 0 0 0 0.470 0.754 1.000 8 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 120022 1 1 1 1 1 0 0 0 0 0 0.881 0.758 1.000 9 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPL(2), ALPP(13), ALPPL2(5), FPGS(2), GCH1(1), GGH(3) 518717 26 12 18 8 6 9 3 7 1 0 0.204 0.768 1.000 10 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(2), AASS(2) 342070 4 4 4 2 0 2 0 1 1 0 0.861 0.787 1.000 11 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), CS(5), PC(1) 672578 8 7 5 3 0 0 0 5 3 0 0.681 0.828 1.000 12 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12B(2) 222942 3 3 2 9 2 0 0 0 1 0 1.000 0.858 1.000 13 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(1), PAPSS1(5), PAPSS2(1), SULT1A2(3), SUOX(1) 613543 11 7 9 2 4 2 0 4 1 0 0.359 0.872 1.000 14 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 SPCS1(1) 225000 1 1 1 3 0 0 0 0 1 0 1.000 0.885 1.000 15 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), ITPKA(1), ITPKB(10) 444148 15 10 10 9 3 7 0 3 2 0 0.854 0.890 1.000 16 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(3), HGD(1) 161661 5 4 3 3 1 3 0 1 0 0 0.780 0.942 1.000 17 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MYC(7), SP1(1), SP3(2), TP53(6) 516244 16 10 16 9 2 7 1 4 2 0 0.810 0.945 1.000 18 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), GLS(1), PRODH(4) 430702 7 5 6 3 3 1 1 2 0 0 0.649 0.947 1.000 19 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(3) 278637 3 3 3 5 0 0 0 2 1 0 0.999 0.960 1.000 20 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3D(1), CD3G(2) 235227 3 3 3 7 0 1 0 1 1 0 0.998 0.961 1.000 21 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), SQLE(1) 243414 3 3 3 9 0 0 2 0 1 0 1.000 0.968 1.000 22 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(8), AASDHPPT(2), AASS(2) 502133 12 8 9 7 2 4 0 4 2 0 0.904 0.969 1.000 23 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(1), SNAP25(1) 230341 2 2 2 7 0 0 0 1 1 0 0.999 0.975 1.000 24 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(4), CHKA(1), PDHA2(2), PEMT(4) 503543 12 10 10 5 5 5 1 1 0 0 0.476 0.976 1.000 25 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(4), PNPO(1) 351159 5 5 5 9 1 3 0 0 1 0 0.999 0.981 1.000 26 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(2), GGT1(6), SHMT1(3), SHMT2(1) 423071 12 12 8 5 3 3 1 4 1 0 0.676 0.987 1.000 27 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT2(1), FUT3(6), FUT5(6), FUT6(7) 370970 21 9 12 9 8 5 0 7 1 0 0.639 0.987 1.000 28 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(2), RB1(1), SP1(1), SP3(2) 488712 7 6 7 5 1 4 0 0 2 0 0.873 0.987 1.000 29 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CUL1(2), E2F1(2), RB1(1) 618831 5 5 5 6 2 1 0 0 2 0 0.987 0.988 1.000 30 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(1), CUL1(2), E2F1(2), NEDD8(1), RB1(1), SKP2(1) 626122 8 7 8 6 3 1 0 1 3 0 0.934 0.989 1.000 31 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CUL1(2), E2F1(2), RB1(1), SKP2(1) 635036 7 6 7 7 3 1 0 0 3 0 0.972 0.990 1.000 32 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(2), MST1R(6), TNF(3) 468866 12 8 10 7 1 5 3 2 1 0 0.838 0.994 1.000 33 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(3), MTMR2(4), PHPT1(1), THTPA(2) 464267 10 8 9 8 2 2 0 5 1 0 0.975 0.996 1.000 34 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(3), ACADM(1), ACADS(1), ACAT1(2), ECHS1(1) 400262 8 8 6 5 0 3 0 4 1 0 0.927 0.997 1.000 35 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(5), GLS(1) 565382 6 5 3 6 0 0 0 5 1 0 0.994 0.998 1.000 36 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(3), ECHS1(1), HADHB(1), HSD17B4(4), PPT1(1), PPT2(3) 629310 13 7 8 6 0 8 1 3 1 0 0.724 0.999 1.000 37 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(2), CSNK1E(1), PER1(4) 633431 7 5 6 9 1 2 0 3 1 0 0.999 1.000 1.000 38 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), ACAT2(1), BDH1(1), BDH2(2), HMGCS2(1), OXCT1(2), OXCT2(2) 555702 11 8 9 9 3 3 1 3 1 0 0.970 1.000 1.000 39 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(5), EIF2AK4(1), EIF2B5(4), EIF2S2(1), EIF2S3(2), PPP1CA(1) 840952 14 10 11 6 2 3 1 7 1 0 0.801 1.000 1.000 40 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(1), NFKB1(3), TNFRSF13B(4), TNFSF13(3), TNFSF13B(1), TRAF3(4), TRAF6(1) 1058732 18 9 14 9 3 11 1 1 2 0 0.815 1.000 1.000 41 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 248 ACVR1C(2), AKT2(1), ATF4(4), BDNF(3), BRAF(3), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1F(6), CACNA1G(2), CACNA1H(15), CACNA1I(1), CACNA1S(8), CACNA2D1(3), CACNA2D2(2), CACNA2D3(1), CACNA2D4(3), CACNB2(2), CACNB4(1), CACNG1(1), CACNG3(1), CACNG6(2), CACNG7(1), CHUK(1), DUSP16(2), DUSP2(7), DUSP4(2), DUSP8(1), ECSIT(3), EGF(4), EGFR(4), ELK1(1), FAS(5), FGF12(1), FGF14(1), FGF16(1), FGF21(2), FGF5(1), FGF6(3), FGFR2(2), FGFR4(6), FLNA(4), FLNB(9), FLNC(7), GRB2(1), IKBKB(2), IL1A(2), IL1R1(1), IL1R2(1), KRAS(3), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP4K1(1), MAP4K3(2), MAP4K4(1), MAPK11(1), MAPK7(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MAPKAPK2(1), MAPKAPK5(2), MAPT(16), MEF2C(1), MKNK1(1), MKNK2(3), MOS(2), MYC(7), NF1(2), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(3), NTRK1(3), PAK2(11), PDGFRB(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PPM1A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PTPN5(3), PTPN7(1), PTPRR(3), RAC1(1), RAC3(1), RAF1(4), RAPGEF2(1), RASA1(2), RASA2(2), RASGRF1(2), RASGRF2(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(1), RPS6KA5(1), RPS6KA6(1), RRAS2(1), SOS1(1), SOS2(1), STK3(2), STK4(1), TAOK1(1), TAOK2(2), TGFB2(1), TNF(3), TP53(6), TRAF6(1), ZAK(3) 22091521 322 43 266 421 103 101 13 71 34 0 1.000 1.000 1.000 42 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 137 ACTB(5), ACTG1(6), CHAD(1), COL11A1(7), COL11A2(5), COL17A1(3), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A3(15), COL6A6(4), COMP(2), DES(2), DSC1(3), DSC2(1), DSC3(8), DSG1(20), DSG2(2), DSG3(6), DSG4(2), FN1(2), GJA1(1), GJA4(5), GJA9(5), GJB3(1), GJB4(3), GJB7(3), GJD2(1), GJD4(1), IBSP(5), ITGA6(4), ITGB4(2), KRT1(4), KRT10(2), KRT12(2), KRT14(4), KRT15(3), KRT16(2), KRT17(1), KRT19(2), KRT2(5), KRT20(2), KRT23(4), KRT24(2), KRT25(3), KRT27(6), KRT28(5), KRT3(6), KRT31(3), KRT32(16), KRT33A(5), KRT33B(5), KRT34(2), KRT35(4), KRT36(3), KRT37(16), KRT38(2), KRT39(4), KRT4(7), KRT40(23), KRT5(7), KRT6A(4), KRT6B(5), KRT6C(7), KRT7(3), KRT71(7), KRT72(10), KRT73(4), KRT74(4), KRT75(5), KRT76(6), KRT77(7), KRT78(4), KRT79(3), KRT81(3), KRT82(5), KRT83(4), KRT84(9), KRT85(1), KRT86(3), KRT9(1), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMA5(27), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), LMNA(3), NES(7), PRPH(2), RELN(9), SPP1(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNC(10), TNN(10), TNR(4), TNXB(14), VTN(2), VWF(11) 18620755 618 42 445 629 203 188 30 145 50 2 1.000 1.000 1.000 43 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(5), ACTG1(6), ACTN1(3), ACTN2(1), ACTN4(1), AKT2(1), ARHGAP5(2), BCAR1(2), BCL2(1), BIRC2(1), BRAF(3), CAPN2(4), CAV1(1), CAV2(2), CCND1(1), CCND2(2), CCND3(3), CHAD(1), COL11A1(7), COL11A2(5), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A3(15), COL6A6(4), COMP(2), DOCK1(7), EGF(4), EGFR(4), ELK1(1), ERBB2(3), FARP2(10), FLNA(4), FLNB(9), FLNC(7), FLT1(2), FN1(2), GRB2(1), IBSP(5), ILK(1), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGB3(3), ITGB4(2), KDR(8), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMA5(27), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), MAP2K1(2), MAPK8(1), MET(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PARVA(1), PARVB(7), PARVG(1), PDGFC(1), PDGFRB(2), PDPK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PRKCG(2), PTEN(2), PTK2(2), RAC1(1), RAC3(1), RAF1(4), RAPGEF1(1), RELN(9), RHOA(2), ROCK2(2), SHC2(1), SHC3(1), SOS1(1), SOS2(1), SPP1(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TLN1(6), TLN2(6), TNC(10), TNN(10), TNR(4), TNXB(14), VAV1(3), VAV2(3), VAV3(4), VEGFB(1), VEGFC(2), VTN(2), VWF(11) 27771025 523 42 410 718 150 164 28 133 45 3 1.000 1.000 1.000 44 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADCYAP1R1(4), ADORA1(1), ADORA3(4), ADRA1A(3), ADRA2B(2), ADRA2C(1), ADRB1(1), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1B(3), CALCR(5), CALCRL(2), CCKBR(1), CHRM3(5), CNR2(4), CRHR1(1), CTSG(1), CYSLTR1(1), CYSLTR2(2), DRD2(1), DRD3(1), DRD5(5), EDNRA(1), F2(1), F2R(1), F2RL2(1), F2RL3(1), FPR1(8), FSHR(5), GABBR1(1), GABBR2(3), GABRA1(2), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(3), GABRB1(1), GABRD(2), GABRE(1), GABRG3(6), GABRP(2), GABRQ(4), GABRR1(5), GABRR2(2), GALR1(3), GALR2(1), GALR3(1), GH1(2), GH2(1), GHR(2), GHRHR(2), GHSR(1), GIPR(1), GLP1R(3), GLP2R(3), GLRB(1), GPR156(1), GPR35(1), GPR50(7), GPR63(1), GRIA2(3), GRID1(7), GRID2(5), GRIK1(3), GRIK2(1), GRIK3(1), GRIK4(3), GRIK5(1), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), GRIN3A(13), GRIN3B(10), GRM1(2), GRM2(1), GRM4(1), GRM5(1), GRM6(5), GRM7(1), GRM8(6), HCRTR1(2), HCRTR2(2), HRH1(1), HRH2(1), HRH4(3), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), LEPR(10), LHB(3), LHCGR(3), MAS1(1), MC1R(4), MC3R(2), MC5R(1), MCHR1(2), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(2), NPBWR1(3), NPBWR2(2), NPFFR2(2), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OXTR(1), P2RX3(5), P2RX4(2), P2RX5(4), P2RX7(15), P2RY1(1), P2RY10(1), P2RY11(3), P2RY13(1), P2RY2(5), P2RY4(1), P2RY6(1), P2RY8(10), PARD3(2), PRLHR(1), PRLR(2), PRSS1(4), PRSS3(8), PTAFR(2), PTGFR(1), PTGIR(2), PTH2R(2), RXFP2(4), SCTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6), SSTR5(3), TAAR2(1), TAAR6(2), TAAR8(1), TACR2(4), TACR3(1), THRA(1), THRB(2), TRPV1(5), TSHR(3), VIPR2(1) 16350895 395 41 313 460 85 141 26 119 24 0 1.000 1.000 1.000 45 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 145 APC(4), AXIN2(4), BTRC(1), CAMK2G(1), CCND1(1), CCND2(2), CCND3(3), CER1(4), CHD8(4), CREBBP(7), CSNK1A1(2), CSNK1A1L(5), CSNK1E(1), CSNK2A1(4), CSNK2B(1), CUL1(2), DAAM2(4), DKK2(2), DVL1(1), EP300(5), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), LRP5(2), LRP6(1), MAPK8(1), MMP7(2), MYC(7), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NKD2(2), PLCB1(8), PLCB3(2), PLCB4(2), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE2(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PSEN1(1), RAC1(1), RAC3(1), RHOA(2), ROCK2(2), SENP2(1), SFRP2(3), SFRP4(2), SKP1(1), SMAD3(1), SOX17(1), TBL1XR1(2), TCF7(2), TCF7L1(2), TP53(6), VANGL1(4), VANGL2(1), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2) 11996207 167 41 148 199 44 48 5 44 26 0 1.000 1.000 1.000 46 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(3), CADM1(1), CADM3(1), CD2(1), CD22(2), CD226(4), CD274(1), CD276(7), CD58(1), CD6(8), CD80(2), CD86(1), CD8B(5), CD99(3), CDH1(1), CDH15(2), CDH2(4), CDH3(6), CDH4(2), CDH5(5), CLDN16(6), CLDN18(1), CLDN22(2), CLDN5(2), CLDN6(3), CLDN8(4), CNTN1(2), CNTN2(5), CNTNAP1(2), CTLA4(1), HLA-A(93), HLA-B(42), HLA-C(60), HLA-DMA(4), HLA-DMB(1), HLA-DOB(1), HLA-DPA1(29), HLA-DPB1(23), HLA-DQA1(19), HLA-DQA2(8), HLA-DQB1(30), HLA-DRA(2), HLA-DRB1(46), HLA-DRB5(31), HLA-E(1), HLA-G(5), ICAM1(6), ICAM3(9), ICOSLG(4), ITGA4(5), ITGA6(4), ITGA8(1), ITGA9(2), ITGAL(1), ITGAM(6), L1CAM(1), MADCAM1(14), MPZL1(1), NCAM1(1), NCAM2(5), NEGR1(3), NFASC(5), NLGN1(1), NRCAM(2), NRXN1(2), NRXN2(2), NRXN3(3), PDCD1LG2(2), PTPRC(1), PTPRF(1), PTPRM(1), PVR(3), PVRL1(3), PVRL2(1), SDC3(5), SDC4(5), SELE(3), SELL(3), SELP(6), SELPLG(9), SIGLEC1(4), VCAM1(1), VCAN(21) 10914862 630 41 426 469 101 227 28 226 40 8 1.000 1.000 1.000 47 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 252 ACVR1(1), BMP2(2), BMP7(1), BMPR1A(3), CCL11(1), CCL14(5), CCL15(1), CCL18(1), CCL2(1), CCL23(2), CCL24(3), CCL25(2), CCL27(3), CCL4(3), CCL8(3), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CD27(3), CLCF1(1), CRLF2(1), CSF1(2), CSF2(1), CSF2RA(2), CSF2RB(3), CSF3R(2), CX3CL1(2), CX3CR1(5), CXCL14(1), CXCL2(1), CXCL3(1), CXCR4(4), CXCR6(1), EDA(1), EDA2R(4), EGF(4), EGFR(4), EPOR(1), FAS(5), FLT1(2), FLT3(1), FLT3LG(1), FLT4(5), GDF5(3), GH1(2), GH2(1), GHR(2), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), IL10RA(4), IL10RB(2), IL11(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL13RA1(1), IL15RA(1), IL17B(1), IL17RA(2), IL17RB(1), IL18R1(1), IL19(1), IL1A(2), IL1R1(1), IL1R2(1), IL20RA(4), IL21R(1), IL22RA1(2), IL22RA2(2), IL23R(2), IL24(3), IL25(1), IL2RA(1), IL2RB(2), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL6ST(4), IL7R(7), IL9(1), IL9R(2), INHBB(1), INHBC(1), INHBE(1), KDR(8), KITLG(1), LEPR(10), LIFR(3), LTA(5), LTB(5), MET(2), NGFR(2), OSMR(2), PDGFC(1), PDGFRB(2), PLEKHO2(5), PRLR(2), TGFB2(1), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(4), TNFRSF14(6), TNFRSF18(3), TNFRSF19(4), TNFRSF1B(3), TNFRSF21(1), TNFRSF6B(1), TNFRSF8(6), TNFSF13(3), TNFSF13B(1), TNFSF15(1), TNFSF4(1), TNFSF9(1), TPO(10), VEGFB(1), VEGFC(2), XCL1(2) 13120864 357 40 270 288 57 138 28 110 24 0 1.000 1.000 1.000 48 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(3), ABLIM1(2), ABLIM2(1), ABLIM3(4), ARHGEF12(2), CXCR4(4), DCC(4), EFNA1(1), EFNA3(3), EFNB1(1), EPHA1(3), EPHA2(2), EPHA3(7), EPHA5(3), EPHA6(3), EPHA7(2), EPHA8(1), EPHB1(3), EPHB2(1), EPHB4(2), EPHB6(2), GNAI2(2), KRAS(3), L1CAM(1), LIMK1(1), LIMK2(1), LRRC4C(1), MET(2), NCK1(2), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NGEF(1), NRP1(5), NTN4(4), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PLXNA1(1), PLXNA2(10), PLXNA3(4), PLXNB1(1), PLXNB2(5), PLXNB3(10), PLXNC1(1), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC3(1), RASA1(2), RGS3(4), RHOA(2), ROBO1(2), ROBO2(3), ROBO3(2), ROCK2(2), SEMA3A(1), SEMA3C(3), SEMA3D(4), SEMA3E(4), SEMA3F(1), SEMA3G(1), SEMA4B(2), SEMA4D(5), SEMA4F(1), SEMA4G(1), SEMA5A(2), SEMA5B(6), SEMA6A(2), SEMA6B(2), SEMA6C(2), SEMA6D(7), SEMA7A(1), SLIT1(2), SLIT2(3), SLIT3(4), SRGAP1(2), SRGAP2(2), SRGAP3(1), UNC5B(7), UNC5C(6), UNC5D(1) 14771076 239 39 198 368 74 75 11 69 10 0 1.000 1.000 1.000 49 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 152 AKT2(1), CBL(1), CBLB(1), CBLC(5), CCND1(1), CCND2(2), CCND3(3), CISH(1), CLCF1(1), CREBBP(7), CRLF2(1), CSF2(1), CSF2RA(2), CSF2RB(3), CSF3R(2), EP300(5), EPOR(1), GH1(2), GH2(1), GHR(2), GRB2(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), IL10RA(4), IL10RB(2), IL11(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL13RA1(1), IL15RA(1), IL19(1), IL20RA(4), IL21R(1), IL22RA1(2), IL22RA2(2), IL23R(2), IL24(3), IL2RA(1), IL2RB(2), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL6ST(4), IL7R(7), IL9(1), IL9R(2), JAK1(2), JAK2(2), JAK3(2), LEPR(10), LIFR(3), MYC(7), OSMR(2), PIAS1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIM1(38), PRLR(2), PTPN6(4), SOCS1(9), SOCS3(1), SOCS7(2), SOS1(1), SOS2(1), SPRED1(1), SPRED2(1), SPRY2(3), SPRY3(1), STAT1(1), STAT2(3), STAT3(8), STAT6(4), TPO(10), TYK2(3) 10729832 283 39 230 218 32 109 23 94 22 3 1.000 1.000 1.000 50 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(3), CD247(1), CD48(2), CSF2(1), FAS(5), FCGR3A(15), GRB2(1), GZMB(5), HLA-A(93), HLA-B(42), HLA-C(60), HLA-E(1), HLA-G(5), ICAM1(6), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), ITGAL(1), KIR2DL3(2), KIR3DL1(16), KIR3DL2(3), KLRC3(8), KLRK1(1), KRAS(3), LCP2(1), MAP2K1(2), MICA(31), MICB(8), NCR1(1), NCR2(3), NCR3(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PPP3CA(1), PPP3CC(1), PRF1(2), PRKCG(2), PTK2B(4), PTPN6(4), RAC1(1), RAC3(1), RAF1(4), SHC2(1), SHC3(1), SOS1(1), SOS2(1), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1), ULBP3(2), VAV1(3), VAV2(3), VAV3(4), ZAP70(1) 8385448 435 38 310 334 63 151 18 168 31 4 1.000 1.000 1.000 51 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT2(1), BCL10(2), BTK(2), CARD11(12), CD19(2), CD22(2), CD72(2), CD79A(2), CD79B(6), CHUK(1), CR2(7), FCGR2B(1), IKBKB(2), KRAS(3), LILRB3(34), LYN(2), MALT1(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG2(5), PPP3CA(1), PPP3CC(1), PTPN6(4), RAC1(1), RAC3(1), VAV1(3), VAV2(3), VAV3(4) 5567713 140 37 111 135 23 46 5 47 19 0 1.000 1.000 1.000 52 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ACTN1(3), ACTN2(1), ACTN4(1), APC(4), ARHGEF1(1), ARHGEF12(2), ARHGEF4(2), ARPC1B(3), BAIAP2(4), BCAR1(2), BRAF(3), CHRM3(5), CSK(3), DIAPH3(2), DOCK1(7), EGF(4), EGFR(4), EZR(1), F2(1), F2R(1), FGF12(1), FGF14(1), FGF16(1), FGF21(2), FGF5(1), FGF6(3), FGFR2(2), FGFR4(6), FN1(2), GNA13(2), GSN(4), IQGAP2(4), IQGAP3(8), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGAD(2), ITGAE(8), ITGAL(1), ITGAM(6), ITGAX(6), ITGB3(3), ITGB4(2), KRAS(3), LIMK1(1), LIMK2(1), MAP2K1(2), MOS(2), MSN(2), MYH10(3), MYH14(4), MYH9(6), MYLK(8), NCKAP1(2), NCKAP1L(1), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PDGFRB(2), PFN1(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP4K2A(3), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PPP1R12B(1), PTK2(2), RAC1(1), RAC3(1), RAF1(4), RHOA(2), ROCK2(2), RRAS2(1), SCIN(5), SOS1(1), SOS2(1), SSH1(2), SSH2(3), SSH3(1), TIAM1(8), TIAM2(9), TMSB4X(7), VAV1(3), VAV2(3), VAV3(4), WAS(1), WASF1(1), WASL(1) 20834515 297 37 237 417 86 90 17 83 20 1 1.000 1.000 1.000 53 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(1), ACVRL1(1), AURKB(3), BMPR1A(3), BUB1(1), CDKL1(2), CDKL2(1), CDS1(1), CDS2(1), CLK2(2), CSNK2A1(4), CSNK2B(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), INPP4A(3), INPP4B(5), INPP5A(2), INPPL1(1), ITPKA(1), ITPKB(10), MAP3K10(1), MOS(2), NEK1(8), NEK3(3), OCRL(1), PAK4(2), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3CA(2), PIK3CG(3), PIM2(1), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCG1(3), PLCG2(5), PRKACA(1), PRKACG(2), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), PRKG1(3), RAF1(4), RPS6KA1(2), RPS6KA2(1), STK11(1) 8511200 138 37 120 214 34 38 7 42 17 0 1.000 1.000 1.000 54 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 169 ADCY2(7), ADCY3(2), ADCY4(2), ADCY8(1), ADCY9(4), ADRA1A(3), ADRA1D(2), ADRB1(1), ADRB2(3), AGTR1(2), ATP2A3(2), ATP2B4(1), AVPR1B(3), BST1(4), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1F(6), CACNA1G(2), CACNA1H(15), CACNA1I(1), CACNA1S(8), CAMK2G(1), CAMK4(1), CCKBR(1), CHRM3(5), CHRNA7(1), CYSLTR1(1), CYSLTR2(2), EDNRA(1), EGFR(4), ERBB2(3), ERBB3(1), ERBB4(4), F2R(1), GNA14(1), GNAS(1), GRIN2A(2), GRIN2C(3), GRIN2D(1), GRM1(2), GRM5(1), HRH1(1), HRH2(1), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), LHCGR(3), MYLK(8), NOS1(3), OXTR(1), P2RX3(5), P2RX4(2), P2RX5(4), P2RX7(15), PDE1B(1), PDE1C(5), PDGFRB(2), PHKA1(1), PHKB(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PPID(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PTAFR(2), PTGFR(1), PTK2B(4), RYR1(4), RYR2(9), RYR3(6), SLC25A5(2), SLC25A6(2), SLC8A1(1), SLC8A3(1), SPHK1(1), SPHK2(1), TACR2(4), TACR3(1), TRPC1(1), VDAC3(2) 20645101 293 36 238 523 86 82 17 72 35 1 1.000 1.000 1.000 55 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(5), ACTG1(6), ACTN1(3), ACTN2(1), ACTN4(1), AKT2(1), AMOTL1(5), ASH1L(2), CGN(5), CLDN16(6), CLDN18(1), CLDN22(2), CLDN5(2), CLDN6(3), CLDN8(4), CSNK2A1(4), CSNK2B(1), CTNNA2(3), CTNNA3(6), CTTN(1), EPB41(2), EPB41L1(1), EPB41L2(1), EPB41L3(6), EXOC4(3), GNAI2(2), HCLS1(7), IGSF5(4), INADL(11), KRAS(3), LLGL1(2), LLGL2(9), MAGI1(3), MAGI2(4), MLLT4(1), MPDZ(6), MYH1(4), MYH10(3), MYH11(5), MYH13(5), MYH14(4), MYH15(6), MYH2(2), MYH3(1), MYH4(14), MYH6(6), MYH7(1), MYH7B(4), MYH8(5), MYH9(6), PARD3(2), PARD6G(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(13), PPP2R3B(3), PPP2R4(1), PRKCD(1), PRKCG(2), PRKCQ(2), PTEN(2), RHOA(2), RRAS2(1), SPTAN1(1), SYMPK(2), TJP1(3), TJP2(5), TJP3(5), YES1(1), ZAK(3) 14265675 249 36 196 329 70 77 21 57 21 3 1.000 1.000 1.000 56 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(15), CALR(1), CANX(1), CD8B(5), CIITA(10), CTSB(4), CTSS(2), HLA-A(93), HLA-B(42), HLA-C(60), HLA-DMA(4), HLA-DMB(1), HLA-DOB(1), HLA-DPA1(29), HLA-DPB1(23), HLA-DQA1(19), HLA-DQA2(8), HLA-DQB1(30), HLA-DRA(2), HLA-DRB1(46), HLA-DRB5(31), HLA-E(1), HLA-G(5), HSP90AA1(2), HSP90AB1(4), IFI30(2), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), KIR2DL3(2), KIR3DL1(16), KIR3DL2(3), KIR3DL3(3), KLRC3(8), KLRC4(4), LGMN(1), LTA(5), NFYA(1), NFYC(2), PDIA3(1), RFX5(4), RFXANK(2), RFXAP(1), TAP1(5), TAP2(5) 3444235 523 36 358 292 67 182 24 213 34 3 1.000 1.000 1.000 57 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDS1(1), CDS2(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(2), INPP5B(4), INPPL1(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), OCRL(1), PI4KA(4), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3C3(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP4K2A(3), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PRKCG(2), PTEN(2), SYNJ1(2), SYNJ2(3) 9394739 133 35 116 252 29 38 8 37 21 0 1.000 1.000 1.000 58 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(4), CD36(1), CD44(3), CHAD(1), COL11A1(7), COL11A2(5), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A3(15), COL6A6(4), FN1(2), FNDC1(8), FNDC3A(2), FNDC4(1), GP6(2), GP9(1), HMMR(10), HSPG2(15), IBSP(5), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGB3(3), ITGB4(2), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMA5(27), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), RELN(9), SDC3(5), SDC4(5), SPP1(1), SV2B(2), SV2C(3), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNC(10), TNN(10), TNR(4), TNXB(14), VTN(2), VWF(11) 16915114 376 35 290 520 129 117 21 79 27 3 1.000 1.000 1.000 59 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT2(1), BCL10(2), CARD11(12), CBL(1), CBLB(1), CBLC(5), CD247(1), CD3D(1), CD3G(2), CD8B(5), CHUK(1), CSF2(1), CTLA4(1), GRAP2(1), GRB2(1), IKBKB(2), KRAS(3), LCP2(1), MALT1(1), NCK1(2), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCQ(2), PTPN6(4), PTPRC(1), RHOA(2), SOS1(1), SOS2(1), TEC(2), TNF(3), VAV1(3), VAV2(3), VAV3(4), ZAP70(1) 7551386 135 35 113 156 30 39 6 41 19 0 1.000 1.000 1.000 60 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(5), BCL2(1), CABIN1(4), CAMK4(1), CD3G(2), CDKN1A(4), CREBBP(7), CSF2(1), CSNK2A1(4), CSNK2B(1), CTLA4(1), EGR2(1), EP300(5), FCGR3A(15), GATA3(2), GATA4(2), IFNA1(2), IL2RA(1), IL3(3), IL6(2), JUNB(1), MAPK8(1), MEF2B(3), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB2(3), NFKBIB(1), NFKBIE(6), NUP214(3), P2RX7(15), PPP3CC(1), PTPRC(1), SFN(2), SLA(1), SP1(1), SP3(2), TNF(3), VAV1(3), VAV2(3), VAV3(4), XPO5(2) 6765186 131 34 107 134 28 42 5 39 17 0 1.000 1.000 1.000 61 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 164 ADORA1(1), ADORA3(4), ADRA1A(3), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1B(3), CCKBR(1), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CCRL2(4), CHML(2), CHRM3(5), CMKLR1(1), CNR2(4), CX3CR1(5), CXCR4(4), DRD2(1), DRD3(1), DRD5(5), EDNRA(1), F2R(1), F2RL2(1), F2RL3(1), FPR1(8), FSHR(5), GALR1(3), GALR2(1), GALR3(1), GALT(2), GHSR(1), GPR35(1), GPR37L1(1), GPR50(7), GPR63(1), GPR87(2), HCRTR1(2), HCRTR2(2), HRH1(1), HRH2(1), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), LHCGR(3), MAS1(1), MC1R(4), MC3R(2), MC5R(1), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(2), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OR10A5(1), OR11A1(3), OR12D3(5), OR1F1(4), OR1Q1(3), OR2H1(4), OR5V1(4), OR7A5(1), OR7C1(7), OXTR(1), P2RY1(1), P2RY10(1), P2RY11(3), P2RY13(1), P2RY2(5), P2RY6(1), PTAFR(2), PTGFR(1), PTGIR(2), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6) 8860857 204 34 162 251 37 77 12 71 7 0 1.000 1.000 1.000 62 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(3), AKT2(1), BRAF(3), BTC(5), CAMK2G(1), CBL(1), CBLB(1), CBLC(5), CDKN1A(4), CDKN1B(1), EGF(4), EGFR(4), ELK1(1), ERBB2(3), ERBB3(1), ERBB4(4), GAB1(1), GRB2(1), KRAS(3), MAP2K1(2), MAP2K4(1), MAPK8(1), MYC(7), NCK1(2), NRG1(4), NRG2(1), NRG3(2), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PRKCG(2), PTK2(2), RAF1(4), RPS6KB2(5), SHC2(1), SHC3(1), SOS1(1), SOS2(1) 7685624 123 34 100 169 22 43 10 40 8 0 1.000 1.000 1.000 63 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(3), ANAPC1(3), ANAPC4(3), ATM(8), ATR(6), BUB1(1), BUB1B(1), CCNA1(1), CCNB2(2), CCNB3(1), CCND1(1), CCND2(2), CCND3(3), CDC14A(1), CDC16(3), CDC25C(4), CDC27(16), CDC6(5), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), CHEK2(2), CREBBP(7), CUL1(2), DBF4(2), E2F1(2), E2F2(3), E2F3(1), EP300(5), ESPL1(12), FZR1(1), HDAC2(2), MAD1L1(3), MAD2L1(1), MCM3(2), MCM4(2), MCM5(3), MCM7(2), PKMYT1(2), PLK1(1), RB1(1), RBL2(3), SFN(2), SKP1(1), SKP2(1), SMAD3(1), SMC1B(8), TGFB2(1), TP53(6), YWHAE(1) 10111915 151 34 116 130 34 49 2 46 18 2 1.000 1.000 1.000 64 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 82 AKT2(1), ATM(8), BCL2(1), BIRC2(1), CAPN2(4), CASP10(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), CSF2RB(3), DFFA(1), ENDOG(2), FAS(5), IKBKB(2), IL1A(2), IL1R1(1), IL3(3), IL3RA(4), IRAK1(3), IRAK2(5), IRAK3(1), IRAK4(4), MYD88(7), NFKB1(3), NFKB2(3), NFKBIA(3), NTRK1(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1), TP53(6) 6258653 124 34 94 114 21 47 1 37 18 0 1.000 1.000 1.000 65 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(4), ACTB(5), ACTG1(6), ACTN1(3), ACTN2(1), ACTN4(1), ACVR1C(2), BAIAP2(4), CDH1(1), CREBBP(7), CSNK2A1(4), CSNK2B(1), CTNNA2(3), CTNNA3(6), CTNND1(1), EGFR(4), EP300(5), ERBB2(3), FARP2(10), FER(3), INSR(2), LMO7(10), MET(2), MLLT4(1), PARD3(2), PTPN1(1), PTPN6(4), PTPRB(8), PTPRF(1), PTPRJ(6), PTPRM(1), PVRL1(3), PVRL2(1), PVRL4(1), RAC1(1), RAC3(1), RHOA(2), SMAD3(1), SNAI1(2), SORBS1(4), SSX2IP(3), TCF7(2), TCF7L1(2), TJP1(3), WAS(1), WASF1(1), WASF3(3), WASL(1), YES1(1) 8839792 145 33 125 172 29 54 8 40 14 0 1.000 1.000 1.000 66 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY8(1), ATF4(4), BRAF(3), CACNA1C(8), CAMK2G(1), CAMK4(1), CREBBP(7), EP300(5), GRIA2(3), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), GRM1(2), GRM5(1), ITPR1(4), ITPR2(3), ITPR3(2), KRAS(3), MAP2K1(2), PLCB1(8), PLCB3(2), PLCB4(2), PPP1CA(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), RAF1(4), RAPGEF3(8), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1) 7567297 96 33 85 187 23 22 4 32 15 0 1.000 1.000 1.000 67 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), CAMK2G(1), CREB3L1(2), CREB3L2(1), CREB3L4(2), CREBBP(7), DCT(1), DVL1(1), EDN1(3), EP300(5), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), GNAI2(2), GNAS(1), KITLG(1), KRAS(3), MAP2K1(2), MC1R(4), MITF(1), PLCB1(8), PLCB3(2), PLCB4(2), POMC(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), RAF1(4), TCF7(2), TCF7L1(2), TYR(9), TYRP1(1), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2) 8132148 114 33 95 167 25 35 6 34 14 0 1.000 1.000 1.000 68 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(1), ACVR1C(2), ACVRL1(1), BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP7(1), BMP8A(1), BMPR1A(3), CDKN2B(1), CHRD(4), COMP(2), CREBBP(7), CUL1(2), EP300(5), GDF5(3), ID3(2), INHBB(1), INHBC(1), INHBE(1), LEFTY1(6), LTBP1(4), MYC(7), NODAL(1), PITX2(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL2(3), RHOA(2), ROCK2(2), RPS6KB2(5), SKP1(1), SMAD3(1), SMAD7(1), SMAD9(3), SMURF1(1), SMURF2(1), SP1(1), TGFB2(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNF(3), ZFYVE9(2) 7290751 107 32 91 118 23 40 3 29 12 0 1.000 1.000 1.000 69 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT2(1), CASP8(3), CCL4(3), CD80(2), CD86(1), CHUK(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), IFNAR1(4), IFNAR2(3), IKBKB(2), IKBKE(4), IL12B(2), IL6(2), IRAK1(3), IRAK4(4), IRF3(3), IRF5(1), IRF7(2), LBP(8), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAPK11(1), MAPK8(1), MYD88(7), NFKB1(3), NFKB2(3), NFKBIA(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), RAC1(1), SPP1(1), STAT1(1), TIRAP(5), TLR1(5), TLR2(2), TLR3(2), TLR4(2), TLR5(4), TLR6(1), TLR7(1), TLR8(2), TNF(3), TRAF3(4), TRAF6(1) 6636559 136 32 110 138 28 50 8 35 15 0 1.000 1.000 1.000 70 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(4), CD19(2), CD1A(2), CD1B(1), CD1C(2), CD1D(1), CD1E(3), CD2(1), CD22(2), CD33(10), CD36(1), CD3D(1), CD3G(2), CD44(3), CD5(3), CD8B(5), CR1(18), CR2(7), CSF1(2), CSF2(1), CSF2RA(2), CSF3R(2), EPOR(1), FCER2(3), FLT3(1), FLT3LG(1), GP9(1), HLA-DRA(2), HLA-DRB1(46), HLA-DRB5(31), IL11(1), IL1A(2), IL1R1(1), IL1R2(1), IL2RA(1), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL7R(7), IL9R(2), ITGA1(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGAM(6), ITGB3(3), KITLG(1), MME(4), TFRC(2), TNF(3), TPO(10) 6159478 251 32 179 179 38 101 20 73 18 1 1.000 1.000 1.000 71 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADRA1A(3), ADRA1D(2), ADRB1(1), ADRB2(3), ATP1A4(1), ATP2A3(2), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1S(8), CALR(1), CAMK2G(1), CAMK4(1), CASQ1(1), CASQ2(4), CHRM3(5), GJA1(1), GJA4(5), GJB3(1), GJB4(3), GNAI2(2), GNB3(1), GNGT1(1), GRK4(6), GRK5(2), GRK6(1), ITPR1(4), ITPR2(3), ITPR3(2), KCNB1(1), KCNJ3(1), KCNJ5(1), PLCB3(2), PRKACA(1), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), RGS1(1), RGS11(3), RGS14(2), RGS18(2), RGS3(4), RGS6(1), RGS7(1), RGS9(1), RYR1(4), RYR2(9), RYR3(6), SFN(2), SLC8A1(1), SLC8A3(1) 14188441 157 31 128 361 42 55 7 34 18 1 1.000 1.000 1.000 72 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BFAR(4), BTK(2), CAD(1), CASP10(2), CASP8(3), CSNK1A1(2), DFFA(1), EGFR(4), EPHB2(1), FAF1(1), IL1A(2), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MET(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PFN1(3), PTPN13(8), RALBP1(1), TNFRSF6B(1), TP53(6), TPX2(1), TUFM(1) 5537992 77 31 69 95 16 25 4 19 13 0 1.000 1.000 1.000 73 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(2), ASH2L(1), CTCFL(5), DOT1L(2), EHMT1(1), EHMT2(2), EZH2(7), JMJD4(3), KDM6A(1), MEN1(1), NSD1(6), PAXIP1(2), PPP1CA(1), PRDM2(7), PRDM6(3), PRDM7(7), PRDM9(18), PRMT6(2), PRMT8(1), SETD1A(1), SETD1B(9), SETD2(3), SETDB2(2), SETMAR(5), SMYD3(3), SUV39H1(1), SUV39H2(1), SUV420H1(1), SUV420H2(1), WHSC1(2), WHSC1L1(1) 9378899 102 30 77 86 19 30 6 37 9 1 1.000 1.000 1.000 74 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 67 BCL2(1), BIRC2(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), FAS(5), GZMB(5), IKBKB(2), IRF1(3), IRF2(1), IRF3(3), IRF4(9), IRF5(1), IRF7(2), LTA(5), MAP2K4(1), MAP3K1(7), MYC(7), NFKB1(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PLEKHG5(2), PRF1(2), TNF(3), TNFRSF10B(4), TNFRSF1B(3), TNFRSF21(1), TP53(6), TP73(1), TRAF1(2), TRAF3(4) 4332475 112 30 96 94 21 36 7 31 17 0 1.000 1.000 1.000 75 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 83 AGL(6), AMY2A(1), AMY2B(2), ASCC3(5), ATP13A2(1), DDX18(2), DDX23(1), DDX41(2), DDX47(2), DDX51(6), DDX52(4), DDX54(2), DDX55(3), DHX58(5), ENPP1(3), ENPP3(3), ENTPD7(3), EP400(7), ERCC2(4), G6PC2(6), GAA(1), GANC(5), GBA(2), GBE1(3), GUSB(1), GYS2(2), HK1(1), HK2(4), HK3(1), IFIH1(7), LYZL1(1), MGAM(12), MOV10L1(17), NUDT5(1), PGM1(4), PGM3(1), PYGB(6), PYGL(4), RAD54B(2), SETX(8), SI(5), SKIV2L2(2), SMARCA2(8), SMARCA5(1), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2A1(9), UGT2B11(9), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), UXS1(1) 9719884 229 30 165 228 37 79 13 77 23 0 1.000 1.000 1.000 76 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), CREBBP(7), DLL3(1), DTX1(4), DTX2(2), DTX3L(3), DTX4(2), DVL1(1), EP300(5), HDAC2(2), JAG1(3), JAG2(4), LFNG(1), MAML1(4), MAML2(3), MAML3(10), NCOR2(9), NOTCH1(2), NOTCH2(10), NOTCH3(5), NOTCH4(10), NUMB(2), NUMBL(1), PSEN1(1), PTCRA(6), RBPJL(6) 5412659 105 30 83 112 22 30 3 35 15 0 1.000 1.000 1.000 77 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(3), CHUK(1), ELK1(1), GRB2(1), IKBKB(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP4K1(1), MAP4K3(2), MAP4K4(1), MAP4K5(3), MAPK11(1), MAPK4(1), MAPK6(3), MAPK7(1), MAPK8(1), MAPKAPK2(1), MAPKAPK5(2), MEF2B(3), MEF2C(1), MKNK1(1), MKNK2(3), MYC(7), NFKB1(3), NFKBIA(3), PAK2(11), RAC1(1), RAF1(4), RPS6KA1(2), RPS6KA2(1), RPS6KA5(1), RPS6KB2(5), SP1(1), STAT1(1), TGFB2(1) 7345625 98 30 81 133 16 29 9 32 12 0 1.000 1.000 1.000 78 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ATF1(1), ATF4(4), ATF5(2), ATP2A3(2), CALCA(1), CAMK2G(1), CNN1(1), CRHR1(1), DGKZ(4), ETS2(2), GABPB2(1), GBA2(1), GJA1(1), GNB3(1), GNGT1(1), GRK4(6), GRK5(2), GRK6(1), GSTO1(3), GUCA2A(2), GUCA2B(1), GUCY1A3(1), IGFBP1(2), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(4), ITPR2(3), ITPR3(2), NFKB1(3), NOS1(3), OXTR(1), PLCB3(2), PLCD1(2), PLCG1(3), PLCG2(5), PRKACA(1), PRKCD(1), PRKCQ(2), PRKD1(3), RAMP3(1), RGS1(1), RGS11(3), RGS14(2), RGS18(2), RGS3(4), RGS6(1), RGS7(1), RGS9(1), RYR1(4), RYR2(9), RYR3(6), SFN(2), SLC8A1(1), SP1(1), TNXB(14) 13051165 151 30 126 337 38 60 7 33 12 1 1.000 1.000 1.000 79 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT2(1), ASAH1(4), BRAF(3), DRD2(1), EGFR(4), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PI3(6), PITX2(1), PLCB1(8), PLCB3(2), PLCB4(2), RAF1(4), SOS1(1), SOS2(1), STAT3(8), TERF2IP(1) 4316247 73 30 61 104 18 24 2 17 12 0 1.000 1.000 1.000 80 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(3), ACTN1(3), AKT2(1), ANGPTL2(1), BCAR1(2), BRAF(3), CAV1(1), CDKN2A(1), DOCK1(7), EPHB2(1), GRB2(1), ILK(1), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), MAP2K4(1), MAP3K11(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PLCG1(3), PLCG2(5), PTEN(2), PTK2(2), RAF1(4), ROCK2(2), SOS1(1), SOS2(1), TERF2IP(1), TLN1(6), TLN2(6), WAS(1) 9117849 131 30 104 182 34 43 12 32 9 1 1.000 1.000 1.000 81 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD3D(1), CSK(3), CTLA4(1), EPHB2(1), GRAP2(1), GRB2(1), ITPKA(1), ITPKB(10), LCP2(1), NCK1(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PLCG1(3), PTPRC(1), RAF1(4), RASGRP4(1), SOS1(1), SOS2(1), VAV1(3), ZAP70(1) 4245133 78 30 61 66 16 27 7 17 11 0 1.000 1.000 1.000 82 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(8), ABCA10(3), ABCA12(3), ABCA13(31), ABCA2(3), ABCA3(4), ABCA4(8), ABCA5(3), ABCA7(14), ABCA8(9), ABCA9(1), ABCB1(6), ABCB10(1), ABCB11(2), ABCB5(15), ABCB6(1), ABCB8(6), ABCB9(1), ABCC1(3), ABCC10(2), ABCC11(4), ABCC12(7), ABCC2(4), ABCC3(5), ABCC4(2), ABCC5(3), ABCC6(12), ABCC8(1), ABCD2(1), ABCD4(6), ABCG2(3), ABCG4(3), ABCG5(3), ABCG8(5), CFTR(5), TAP1(5), TAP2(5) 8858326 198 29 150 183 51 63 7 53 24 0 1.000 1.000 1.000 83 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADRB1(1), DRD2(1), EGF(4), EGFR(4), GJA1(1), GJD2(1), GNAI2(2), GNAS(1), GRB2(1), GRM1(2), GRM5(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), GUCY2F(3), HTR2A(2), HTR2C(1), ITPR1(4), ITPR2(3), ITPR3(2), KRAS(3), MAP2K1(2), MAPK7(1), NPR1(2), NPR2(1), PDGFC(1), PDGFRB(2), PLCB1(8), PLCB3(2), PLCB4(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKG1(3), PRKG2(1), PRKX(1), RAF1(4), SOS1(1), SOS2(1), TJP1(3), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3D(4), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5) 9863280 135 29 113 244 35 41 6 36 17 0 1.000 1.000 1.000 84 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(2), ACACB(12), AKT2(1), BRAF(3), CBL(1), CBLB(1), CBLC(5), ELK1(1), EXOC7(2), FASN(3), FBP2(2), FOXO1(2), G6PC2(6), GRB2(1), GYS2(2), IKBKB(2), INSR(2), IRS1(2), IRS2(2), IRS4(6), KRAS(3), LIPE(2), MAP2K1(2), MAPK8(1), MKNK1(1), MKNK2(3), PCK1(3), PCK2(1), PDE3A(9), PDPK1(1), PFKM(1), PHKA1(1), PHKB(2), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(8), PRKAA1(1), PRKACA(1), PRKACG(2), PRKAG3(4), PRKX(1), PTPN1(1), PTPRF(1), PYGB(6), PYGL(4), RAF1(4), RAPGEF1(1), RPS6KB2(5), SHC2(1), SHC3(1), SLC2A4(1), SOCS1(9), SOCS3(1), SORBS1(4), SOS1(1), SOS2(1), SREBF1(1), TRIP10(1), TSC1(4) 12082132 163 29 137 274 41 61 7 37 17 0 1.000 1.000 1.000 85 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 BCAR1(2), CAPN10(1), CAPN11(5), CAPN2(4), CAPN3(1), CAPN6(1), CAPN7(1), CAPN9(7), CAV1(1), CAV2(2), CSK(3), DOCK1(7), GIT2(2), GRB2(1), ILK(1), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGAD(2), ITGAE(8), ITGAL(1), ITGAM(6), ITGAX(6), ITGB3(3), ITGB4(2), MAP2K1(2), MAP2K3(4), MAPK4(1), MAPK6(3), MAPK7(1), PAK2(11), PAK4(2), PAK6(3), PDPK1(1), PIK3R2(1), PTK2(2), RAC1(1), RAC3(1), RAPGEF1(1), ROCK2(2), SDCCAG8(2), SHC3(1), SORBS1(4), SOS1(1), TLN1(6), TNS1(15), VAV2(3), VAV3(4) 10157057 170 29 126 249 50 49 11 47 12 1 1.000 1.000 1.000 86 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(3), ACTN2(1), ACTN4(1), ARHGAP5(2), BCAR1(2), CD99(3), CDH5(5), CLDN16(6), CLDN18(1), CLDN22(2), CLDN5(2), CLDN6(3), CLDN8(4), CTNNA2(3), CTNNA3(6), CTNND1(1), CXCR4(4), CYBA(1), CYBB(1), EZR(1), GNAI2(2), ICAM1(6), ITGA4(5), ITGAL(1), ITGAM(6), MAPK11(1), MLLT4(1), MMP2(1), MMP9(3), MSN(2), NCF1(1), NCF2(2), NOX3(2), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PRKCG(2), PTK2(2), PTK2B(4), RAC1(1), RAPGEF3(8), RHOA(2), ROCK2(2), SIPA1(3), TXK(4), VAV1(3), VAV2(3), VAV3(4), VCAM1(1) 9309365 140 28 105 189 32 40 11 36 17 4 1.000 1.000 1.000 87 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(3), CACNA1A(3), CRHR1(1), GNA13(2), GNAI2(2), GNAS(1), GRIA2(3), GRID2(5), GRM1(2), GRM5(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), GUCY2F(3), ITPR1(4), ITPR2(3), ITPR3(2), KRAS(3), LYN(2), MAP2K1(2), NOS1(3), NPR1(2), NPR2(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCB1(8), PLCB3(2), PLCB4(2), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCG(2), PRKG1(3), PRKG2(1), RAF1(4), RYR1(4) 8299633 95 28 85 204 25 26 7 24 13 0 1.000 1.000 1.000 88 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ATF4(4), CACNA1C(8), CACNA1F(6), CACNA1S(8), CAMK2G(1), EGFR(4), ELK1(1), GNAS(1), GNRH1(3), GNRH2(2), GRB2(1), ITPR1(4), ITPR2(3), ITPR3(2), KRAS(3), LHB(3), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K4(1), MAPK11(1), MAPK7(1), MAPK8(1), MMP14(4), MMP2(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCB1(8), PLCB3(2), PLCB4(2), PLD1(4), PLD2(13), PRKACA(1), PRKACG(2), PRKCD(1), PRKX(1), PTK2B(4), RAF1(4), SOS1(1), SOS2(1) 9679478 145 28 118 240 35 44 9 35 22 0 1.000 1.000 1.000 89 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 71 ACACB(12), ACSL3(2), ACSL5(2), ADIPOQ(2), ADIPOR2(1), AKT2(1), CAMKK1(1), CAMKK2(5), CD36(1), CHUK(1), CPT1B(4), CPT1C(1), CPT2(5), G6PC2(6), IKBKB(2), IRS1(2), IRS2(2), IRS4(6), JAK1(2), JAK2(2), JAK3(2), LEPR(10), MAPK8(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), NPY(1), PCK1(3), PCK2(1), POMC(2), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAG3(4), PRKCQ(2), SLC2A4(1), SOCS3(1), STAT3(8), STK11(1), TNF(3), TNFRSF1B(3), TYK2(3) 6213649 126 28 98 149 32 35 12 34 13 0 1.000 1.000 1.000 90 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(1), ADAM17(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), CHUK(1), CSK(3), EGFR(4), IGSF5(4), IKBKB(2), LYN(2), MAP2K4(1), MAPK11(1), MAPK8(1), MET(2), NFKB1(3), NFKB2(3), NFKBIA(3), NOD1(3), PLCG1(3), PLCG2(5), PTPRZ1(13), RAC1(1), TCIRG1(2), TJP1(3) 5259254 76 28 64 95 23 18 7 17 11 0 1.000 1.000 1.000 91 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(7), EP300(5), IKBKB(2), MAP2K3(4), MAPK11(1), MYD88(7), NFKB1(3), NFKBIA(3), TLR2(2), TNF(3) 2183744 38 28 33 23 6 9 1 8 14 0 0.980 1.000 1.000 92 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT2(1), CDKN1B(1), CDKN2A(1), ERBB4(4), F2RL2(1), GAB1(1), GRB2(1), IGFBP1(2), INPPL1(1), IRS1(2), IRS2(2), IRS4(6), MET(2), MYC(7), NOLC1(2), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PARD3(2), PIK3CA(2), PIK3CD(1), PREX1(8), PTEN(2), PTK2(2), PTPN1(1), RPS6KA1(2), RPS6KA2(1), SFN(2), SLC2A4(1), SOS1(1), SOS2(1), TSC1(4), YWHAE(1) 5630802 88 28 68 130 15 29 6 29 9 0 1.000 1.000 1.000 93 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(1), BCR(1), BTK(2), CD19(2), CSK(3), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(10), LYN(2), MAP2K1(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PI3(6), PIK3CA(2), PIK3CD(1), PLCG2(5), RAF1(4), SOS1(1), SOS2(1), VAV1(3) 3924619 66 28 58 87 20 16 3 14 13 0 1.000 1.000 1.000 94 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), AKAP1(4), AKAP10(3), AKAP11(5), AKAP12(10), AKAP2(5), AKAP3(4), AKAP4(3), AKAP5(2), AKAP6(8), AKAP7(3), AKAP9(8), ARHGEF1(1), GNA13(2), GNA14(1), GNAI2(2), GNB3(1), GNGT1(1), IL18BP(1), ITPR1(4), KCNJ3(1), KRAS(3), PALM2(1), PDE1B(1), PDE1C(5), PDE4A(3), PDE4C(2), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), PRKD3(2), RHOA(2) 8578753 120 27 105 182 27 48 5 32 7 1 1.000 1.000 1.000 95 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(4), ALG6(4), CCKBR(1), CCR2(3), CCR3(1), CELSR1(21), CELSR2(1), CELSR3(3), CHRM3(5), CIDEB(1), EDNRA(1), EMR2(4), EMR3(4), F2R(1), FSHR(5), GHRHR(2), GPR116(5), GPR133(4), GPR18(1), GPR55(3), GPR56(4), GRM1(2), HRH4(3), LGR6(3), LPHN2(3), LPHN3(1), P2RY11(3), P2RY13(1), PTGFR(1), SMO(2), SSTR2(1), TSHR(3), VN1R1(9) 4908410 110 27 84 109 21 39 7 42 1 0 1.000 1.000 1.000 96 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(3), CPEB1(1), EGFR(4), ERBB2(3), ERBB4(4), ETS1(1), ETS2(2), ETV6(1), ETV7(2), FMN2(14), GRB2(1), KRAS(3), MAP2K1(2), NOTCH1(2), NOTCH2(10), NOTCH3(5), NOTCH4(10), PIWIL1(4), PIWIL3(2), PIWIL4(6), RAF1(4), SOS1(1), SOS2(1), SPIRE2(1) 3918907 87 27 66 97 15 32 2 30 7 1 1.000 1.000 1.000 97 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 69 A2M(4), C1S(4), C3(5), C4A(6), C4B(2), C4BPA(4), C5(6), C6(3), C7(7), C8A(9), C8B(3), C9(2), CFB(2), CFH(4), CFI(2), CPB2(2), CR1(18), CR2(7), F10(1), F11(1), F12(1), F13A1(8), F13B(1), F2(1), F2R(1), F5(18), F7(3), F8(3), F9(1), FGA(2), FGB(1), FGG(1), KLKB1(4), KNG1(6), MASP1(1), MASP2(4), MBL2(4), PLAT(1), PLAUR(4), PLG(4), PROC(2), PROS1(1), SERPINA1(3), SERPINA5(6), SERPINC1(1), SERPIND1(2), SERPINE1(1), SERPINF2(8), SERPING1(1), THBD(1), VWF(11) 7751213 198 27 140 168 43 89 6 48 12 0 1.000 1.000 1.000 98 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(6), ANGPTL2(1), FLNA(4), FLNC(7), GDI1(1), LIMK1(1), MYH2(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PFN1(3), ROCK2(2), WASF1(1), WASL(1) 3571649 60 27 45 67 13 13 6 25 3 0 1.000 1.000 1.000 99 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(3), ATM(8), BUB1(1), BUB1B(1), CCNA1(1), CCNB2(2), CCNB3(1), CCND2(2), CCND3(3), CDAN1(7), CDC14A(1), CDC25C(4), CDC6(5), CDH1(1), CDKN1A(4), CDKN2A(1), CHEK2(2), DTX4(2), E2F1(2), E2F2(3), E2F3(1), EP300(5), ESPL1(12), HDAC2(2), HDAC6(2), HDAC8(1), MAD1L1(3), MAD2L1(1), MCM3(2), MCM4(2), MCM5(3), MCM7(2), MPEG1(6), PLK1(1), PTPRA(2), RB1(1), SKP2(1), TBC1D8(3), TP53(6) 8212512 110 26 87 106 29 39 5 23 13 1 1.000 1.000 1.000 100 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(8), CCNA1(1), CCND1(1), CCND2(2), CCND3(3), CCNG2(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), CREB3L1(2), CREB3L4(2), E2F1(2), E2F2(3), E2F3(1), GBA2(1), MCM3(2), MCM4(2), MCM5(3), MCM7(2), MYC(7), MYT1(1), NACA(7), POLA2(1), POLE(4), PRIM1(1), RB1(1), TFDP2(1), TNXB(14), TP53(6) 5741376 86 26 71 95 18 29 4 27 8 0 1.000 1.000 1.000 101 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADSS(1), ADSSL1(3), AK1(1), AK2(2), AK5(1), AK7(3), ALLC(6), AMPD1(7), AMPD3(3), ATIC(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD2(1), ENTPD3(3), ENTPD4(2), ENTPD5(2), ENTPD6(4), GART(3), GDA(2), GMPR(1), GMPS(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), GUCY2F(3), NPR1(2), NPR2(1), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), NUDT5(1), NUDT9(1), PAICS(2), PAPSS1(5), PAPSS2(1), PDE10A(1), PDE11A(3), PDE1C(5), PDE2A(1), PDE4A(3), PDE4C(2), PDE5A(2), PDE6H(1), PDE9A(4), PFAS(6), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4), PRIM1(1), PRPS1L1(2), PRUNE(1), RFC5(1), RRM1(1), XDH(6) 12165105 164 26 127 255 44 50 9 47 14 0 1.000 1.000 1.000 102 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(2), INPP5B(4), INPPL1(1), ITPKA(1), ITPKB(10), OCRL(1), PI4KA(4), PIK3C3(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIP4K2A(3), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PTEN(2), SYNJ1(2), SYNJ2(3) 5547705 85 26 71 137 17 29 6 18 15 0 1.000 1.000 1.000 103 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(2), ALG1(6), ALG10(1), ALG11(1), ALG12(1), ALG14(2), ALG3(1), ALG6(4), ALG8(3), ALG9(1), B3GNT1(1), B3GNT6(1), B3GNT7(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), B4GALT5(1), C1GALT1C1(1), CHST11(1), CHST12(4), CHST13(2), CHST2(1), CHST4(2), CHST6(1), CHSY1(3), DPAGT1(2), EXT1(1), EXT2(1), EXTL1(2), EXTL3(1), FUT8(4), GALNT1(1), GALNT10(1), GALNT12(1), GALNT2(2), GALNT4(5), GALNT5(1), GALNT6(1), GALNT8(8), GALNT9(1), GALNTL5(5), GANAB(3), GCNT1(4), GCNT4(2), HS3ST1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(3), HS6ST2(1), HS6ST3(2), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(1), MGAT1(6), MGAT4A(2), MGAT5(1), MGAT5B(2), NDST1(1), NDST3(1), RPN2(1), ST3GAL4(3), ST6GAL1(3), ST6GALNAC1(3), STT3B(1), UST(1), WBSCR17(1), XYLT1(4), XYLT2(5) 8188685 140 26 114 177 29 51 5 46 9 0 1.000 1.000 1.000 104 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 ATM(8), ATR(6), CASP8(3), CASP9(4), CCNB2(2), CCNB3(1), CCND1(1), CCND2(2), CCND3(3), CCNG1(1), CCNG2(1), CD82(1), CDKN1A(4), CDKN2A(1), CHEK2(2), DDB2(1), EI24(4), FAS(5), GTSE1(6), IGFBP3(1), PERP(2), PTEN(2), SERPINB5(2), SERPINE1(1), SESN1(2), SFN(2), THBS1(5), TNFRSF10B(4), TP53(6), TP73(1) 4868807 84 26 65 77 12 40 2 20 9 1 1.000 1.000 1.000 105 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNA1(2), IKBKB(2), IL1A(2), IL1R1(1), IL6(2), IRAK1(3), IRAK2(5), IRAK3(1), MAP2K3(4), MAP3K1(7), MAPK8(1), MYD88(7), NFKB1(3), NFKBIA(3), TGFB2(1), TNF(3), TRAF6(1) 2181499 49 26 42 38 12 14 2 8 13 0 0.999 1.000 1.000 106 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 CHUK(1), IKBKB(2), IL1A(2), IL1R1(1), IRAK1(3), MAP3K1(7), MYD88(7), NFKB1(3), NFKBIA(3), TLR4(2), TNF(3), TNFAIP3(8), TNFRSF1B(3), TRAF6(1) 1847818 46 26 40 27 7 14 0 8 17 0 0.987 1.000 1.000 107 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 42 BCL2(1), BIRC2(1), CASP2(1), CASP7(3), CASP8(3), CASP9(4), FAS(5), GZMB(5), MAP2K4(1), MAP3K1(7), MCL1(1), MYC(7), NFKB1(3), NFKBIA(3), PARP1(2), PRF1(2), TNF(3), TNFRSF1B(3), TP53(6), TRAF1(2) 2779701 63 25 53 66 12 18 5 18 10 0 1.000 1.000 1.000 108 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(6), BCL2(1), BIRC2(1), CASP2(1), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), GSN(4), LMNA(3), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKBIA(3), NUMA1(2), PAK2(11), PRKCD(1), PSEN1(1), PTK2(2), RASA1(2), RB1(1), SPTAN1(1), TNF(3), TNFRSF1B(3), TRAF1(2) 5181088 72 25 55 99 12 18 5 27 10 0 1.000 1.000 1.000 109 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT2(1), BTK(2), CSF2(1), GRB2(1), IL3(3), KRAS(3), LCP2(1), LYN(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAPK11(1), MAPK8(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PRKCD(1), RAC1(1), RAC3(1), RAF1(4), SOS1(1), SOS2(1), TNF(3), VAV1(3), VAV2(3), VAV3(4) 5257182 68 25 62 129 14 24 7 16 7 0 1.000 1.000 1.000 110 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(3), INPP4B(5), INPP5A(2), INPPL1(1), ITPKA(1), ITPKB(10), OCRL(1), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3CA(2), PIK3CG(3), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCG1(3), PLCG2(5) 3347357 64 25 53 98 15 14 4 18 13 0 1.000 1.000 1.000 111 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(15), HLA-A(93), KLRC3(8), KLRC4(4), MAP2K1(2), PIK3CA(2), PTK2B(4), PTPN6(4), RAC1(1), VAV1(3) 1386527 136 25 94 83 12 39 6 61 17 1 1.000 1.000 1.000 112 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(1), BCL2(1), BCR(1), BTK(2), CD19(2), CD22(2), CR2(7), CSK(3), GRB2(1), ITPR1(4), ITPR2(3), ITPR3(2), LYN(2), MAP4K1(1), NFATC1(6), NFATC2(2), PIK3CA(2), PIK3CD(1), PLCG2(5), PPP3CA(1), PPP3CC(1), PTPRC(1), RAF1(4), SOS1(1), SOS2(1), VAV1(3) 5419191 60 25 54 132 13 22 1 15 9 0 1.000 1.000 1.000 113 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CHUK(1), ELK1(1), IKBKB(2), IRAK1(3), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), MYD88(7), NFKB1(3), NFKBIA(3), PPARA(1), TIRAP(5), TLR10(5), TLR2(2), TLR3(2), TLR4(2), TLR6(1), TLR7(1), TRAF6(1) 2740455 53 25 45 42 10 20 3 9 11 0 1.000 1.000 1.000 114 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(2), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(11), PIK3CA(2), PLA2G4A(1), PLCG1(3), PPP3CA(1), PPP3CC(1), RAF1(4), SOS1(1), VAV1(3) 3140558 54 24 42 63 8 17 8 16 5 0 1.000 1.000 1.000 115 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(4), ARSD(19), ARSE(1), CYP11B1(3), CYP11B2(5), HEMK1(1), HSD17B1(2), HSD17B12(2), HSD17B7(4), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1), SULT2B1(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2A1(9), UGT2B11(9), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4) 3537887 118 24 82 102 17 45 4 43 9 0 1.000 1.000 1.000 116 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(3), ANAPC4(3), BTRC(1), CDC16(3), CDC27(16), CUL1(2), FZR1(1), ITCH(1), SKP1(1), SKP2(1), SMURF1(1), SMURF2(1), UBA1(2), UBE2D3(1), UBE2E3(1), WWP2(1) 3026471 39 24 28 52 7 9 0 14 8 1 1.000 1.000 1.000 117 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 AGT(4), CALR(1), CAMK1G(1), CAMK4(1), CREBBP(7), CSNK1A1(2), EDN1(3), ELSPBP1(11), F2(1), GATA4(2), MAP2K1(2), MAPK8(1), MEF2C(1), MYH2(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NKX2-5(1), NPPA(1), PIK3CA(2), PPP3CA(1), PPP3CC(1), PRKACG(2), RAF1(4) 3721089 61 24 47 65 24 12 4 16 5 0 1.000 1.000 1.000 118 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(3), ATP8A1(2), AVPR1B(3), CCKBR(1), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CX3CR1(5), CXCR4(4), CXCR6(1), EDNRA(1), FPR1(8), FSHR(5), GALR1(3), GALR2(1), GALR3(1), GALT(2), GHSR(1), LHCGR(3), MC1R(4), MC3R(2), MC5R(1), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OXTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6), TACR2(4), TACR3(1), TSHR(3) 3777692 87 24 69 98 18 31 4 30 4 0 1.000 1.000 1.000 119 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(7), APOA1(1), CD36(1), CPT1B(4), CREBBP(7), EHHADH(3), EP300(5), FABP1(2), HSD17B4(4), LPL(1), MYC(7), NCOA1(2), NCOR1(5), NCOR2(9), NFKBIA(3), NRIP1(3), PIK3CA(2), PPARA(1), PRKACG(2), PTGS2(1), RB1(1), SP1(1), TNF(3) 4739156 75 24 68 75 12 28 3 24 8 0 1.000 1.000 1.000 120 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT2(1), ANGPTL2(1), ARHGAP4(2), ARHGEF11(4), BTK(2), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(3), ITPR3(2), LIMK1(1), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PITX2(1), PTEN(2), RACGAP1(1), ROCK2(2), SAG(5), WASF1(1), WASL(1) 5210714 72 24 56 103 20 18 7 23 4 0 1.000 1.000 1.000 121 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 ASAH1(4), ATF1(1), BRAF(3), CREBBP(7), EGR1(1), EGR2(1), EGR4(1), ELK1(1), MAP1B(4), MAP2K4(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), NTRK1(3), OPN1LW(7), PIK3C2G(10), PIK3CA(2), PIK3CD(1), TERF2IP(1), TH(3) 3905858 56 24 48 62 13 22 2 14 5 0 1.000 1.000 1.000 122 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(1), ACTN4(1), DES(2), DMD(8), MYBPC1(3), MYBPC2(10), MYBPC3(4), MYH3(1), MYH6(6), MYH7(1), MYH8(5), MYOM1(13), NEB(16), TMOD1(1), TNNT1(1), TPM1(1), TPM2(1), TTN(121) 10289363 196 24 137 172 64 76 8 34 14 0 1.000 1.000 1.000 123 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(3), EEF1B2(1), EEF2K(3), EIF2AK1(2), EIF2AK2(1), EIF2AK3(5), EIF2B3(2), EIF2B4(2), EIF2B5(4), EIF2S2(1), EIF2S3(2), EIF4A2(1), EIF4G1(2), EIF4G3(2), EIF5B(2), PABPC1(23), PABPC3(8) 3271411 64 24 51 54 16 16 5 20 7 0 1.000 1.000 1.000 124 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 BCL2(1), BCL2A1(7), BOK(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), FAS(5), IKBKE(4), LTA(5), MCL1(1), NFKB1(3), NFKBIA(3), NGFR(2), NTRK1(3), PTPN13(8), TFG(1), TNF(3), TNFRSF1B(3), TRAF1(2), TRAF3(4), TRAF6(1) 3223263 74 23 60 70 16 27 2 20 9 0 1.000 1.000 1.000 125 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(8), ATR(6), BRCA1(12), BRCA2(7), CHEK2(2), FANCA(20), FANCD2(2), FANCE(2), FANCF(1), FANCG(1), HUS1(1), RAD1(3), RAD17(1), RAD50(1), TP53(6) 3182119 73 23 51 50 16 34 5 13 4 1 0.999 1.000 1.000 126 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(2), CD79A(2), CD79B(6), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(4), SOS1(1), VAV1(3) 2789973 48 23 40 55 9 15 5 12 7 0 1.000 1.000 1.000 127 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(3), CAMK2G(1), F2(1), GNGT1(1), GRB2(1), JAK2(2), MAP2K1(2), MAPK8(1), MAPT(16), MYLK(8), PLCG1(3), PTK2B(4), RAF1(4), SOS1(1), STAT1(1), STAT3(8) 3109441 61 23 46 76 16 20 7 13 5 0 1.000 1.000 1.000 128 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(4), ELK1(1), GNAS(1), GNGT1(1), GRB2(1), KLK2(1), MAP2K1(2), MKNK1(1), MKNK2(3), MYC(7), NGFR(2), PPP2CA(1), PTPRR(3), RAF1(4), RPS6KA1(2), RPS6KA5(1), SOS1(1), STAT3(8) 2474866 45 23 43 54 8 17 4 13 3 0 1.000 1.000 1.000 129 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1G(1), ELK1(1), FPR1(8), GNGT1(1), MAP2K1(2), MAP2K3(4), MAP3K1(7), NCF1(1), NCF2(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIA(3), PIK3C2G(10), PLCB1(8), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(4) 2892818 68 23 55 62 16 15 4 20 13 0 1.000 1.000 1.000 130 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH4(4), ADH7(2), ADHFE1(1), AKR1C1(2), AKR1C2(2), AKR1C3(3), AKR1C4(4), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), CYP1A1(2), CYP1A2(2), CYP1B1(2), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2F1(9), CYP2S1(1), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), DHDH(8), EPHX1(6), GSTA2(7), GSTA3(2), GSTA4(1), GSTM3(3), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), GSTZ1(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2A1(9), UGT2B11(9), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4) 4158619 172 23 123 115 23 62 5 61 20 1 1.000 1.000 1.000 131 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(4), ELK1(1), GRB2(1), IL6(2), IL6R(2), IL6ST(4), JAK1(2), JAK2(2), JAK3(2), MAP2K1(2), RAF1(4), SOS1(1), STAT3(8) 1777262 35 23 34 28 6 14 2 9 4 0 0.998 1.000 1.000 132 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADSS(1), AK1(1), AK2(2), AK5(1), ALLC(6), AMPD1(7), AMPD3(3), ATIC(1), ATP5F1(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD2(1), GART(3), GDA(2), GMPS(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), GUCY2F(3), NPR1(2), NPR2(1), NT5C(1), NT5E(2), NT5M(1), PAICS(2), PAPSS1(5), PAPSS2(1), PDE4A(3), PDE4C(2), PDE5A(2), PDE6C(1), PDE9A(4), PFAS(6), POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15), POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4), PRPS1L1(2), PRUNE(1), RRM1(1) 9553111 130 23 103 192 29 41 9 38 13 0 1.000 1.000 1.000 133 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(4), CDR1(2), DGKI(5), IL6ST(4), MRPL19(3), PIGK(1), RPL13(1), RPL14(1), RPL3(1), RPL37(1), RPL3L(2), RPL4(1), RPL5(1), RPL6(1), RPLP2(1), RPS14(2), RPS15(4), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1), RPS6KB2(5), SLC36A2(1), TBC1D10C(1), UBB(1) 3795127 47 23 40 94 6 18 1 14 8 0 1.000 1.000 1.000 134 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT2(1), BCR(1), BTK(2), CD19(2), CDKN2A(1), GAB1(1), ITPR1(4), ITPR2(3), ITPR3(2), LYN(2), PIK3CA(2), PITX2(1), PLCG2(5), PREX1(8), PTEN(2), PTPRC(1), RPS6KA1(2), RPS6KA2(1), SAG(5), TEC(2), VAV1(3) 4072491 51 23 43 120 13 13 2 13 10 0 1.000 1.000 1.000 135 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(4), AR(6), ASAH1(4), BRAF(3), CCL15(1), EGFR(4), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PIK3CA(2), PIK3CD(1), PITX2(1), PTX3(3), RAF1(4) 3963767 57 23 48 92 12 22 2 14 7 0 1.000 1.000 1.000 136 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), EGF(4), EGFR(4), ELK1(1), GRB2(1), JAK1(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1), STAT3(8) 2745230 48 22 43 46 4 25 6 8 5 0 1.000 1.000 1.000 137 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT1(1), AGPAT2(1), CDS1(1), CDS2(1), CHAT(4), CHKA(1), CHPT1(2), CRLS1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), ESCO1(1), ETNK2(1), GNPAT(2), GPAM(5), GPD1(1), GPD1L(1), GPD2(3), LCAT(1), LYPLA1(1), LYPLA2(1), PCYT1B(1), PEMT(4), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLD1(4), PLD2(13), PNPLA3(5), PPAP2B(1), PTDSS2(2) 4960637 86 22 68 88 17 30 5 27 7 0 1.000 1.000 1.000 138 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX12(3), ALOX12B(1), ALOX15(2), ALOX15B(6), CBR3(4), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2J2(1), CYP4A11(4), CYP4A22(19), CYP4F2(4), CYP4F3(1), DHRS4(12), EPHX2(6), GGT1(6), GPX5(1), LTA4H(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PTGES2(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5) 2960201 117 22 79 78 28 32 10 37 10 0 1.000 1.000 1.000 139 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPL(2), ALPP(13), ALPPL2(5), ASCC3(5), ATP13A2(1), DDX18(2), DDX23(1), DDX41(2), DDX47(2), DDX51(6), DDX52(4), DDX54(2), DDX55(3), DHX58(5), ENTPD7(3), EP400(7), ERCC2(4), FPGS(2), GCH1(1), GGH(3), IFIH1(7), MOV10L1(17), NUDT5(1), RAD54B(2), SETX(8), SKIV2L2(2), SMARCA2(8), SMARCA5(1) 4657327 119 22 84 115 30 41 7 31 10 0 1.000 1.000 1.000 140 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(3), ACADL(3), ACADM(1), ACOX1(7), ACOX2(1), ACOX3(1), ACSL3(2), ACSL5(2), ADIPOQ(2), ANGPTL4(4), APOA1(1), APOA5(2), AQP7(3), CD36(1), CPT1B(4), CPT1C(1), CPT2(5), CYP27A1(1), CYP4A11(4), CYP4A22(19), CYP8B1(2), EHHADH(3), FABP1(2), FABP3(1), FABP6(2), FABP7(1), HMGCS2(1), ILK(1), LPL(1), OLR1(2), PCK1(3), PCK2(1), PDPK1(1), PLTP(1), PPARA(1), PPARG(3), SCD(2), SLC27A1(1), SLC27A2(2), SLC27A5(8), SLC27A6(2), SORBS1(4), UCP1(2) 4804945 114 22 85 98 29 34 7 39 5 0 1.000 1.000 1.000 141 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP7(1), BMP8A(1), BTRC(1), CSNK1A1(2), CSNK1A1L(5), CSNK1E(1), CSNK1G3(1), GLI1(2), GLI2(6), GLI3(3), LRP2(16), PRKACA(1), PRKACG(2), PRKX(1), PTCH1(4), PTCH2(3), RAB23(1), SHH(1), SMO(2), STK36(11), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2) 4469825 83 22 68 100 25 23 4 25 6 0 1.000 1.000 1.000 142 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), CHUK(1), EGF(4), EGFR(4), ETS1(1), ETS2(2), HOXA7(3), IKBKB(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKBIA(3), PPP2CA(1), PRKCD(1), PRKCG(2), PRKCQ(2), RAF1(4), SP1(1), TNF(3), TNFRSF1B(3) 3488884 57 22 50 80 12 24 5 9 7 0 1.000 1.000 1.000 143 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(7), ELK1(1), GAB1(1), GRB2(1), ITGA1(3), MAP2K1(2), MAP4K1(1), MAPK8(1), MET(2), PIK3CA(2), PTEN(2), PTK2(2), PTK2B(4), RAF1(4), RASA1(2), SOS1(1), STAT3(8) 3340908 44 22 39 73 3 20 3 10 8 0 1.000 1.000 1.000 144 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 CAV1(1), CHRNA1(1), FLT1(2), FLT4(5), KDR(8), PDE2A(1), PDE3A(9), PRKACG(2), PRKG1(3), PRKG2(1), RYR2(9), SLC7A1(1) 3104373 43 22 35 53 4 17 3 17 2 0 1.000 1.000 1.000 145 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(7), AR(6), ESR2(1), NR0B1(2), NR1H2(2), NR2F2(1), PGR(7), PPARA(1), PPARG(3), RARB(1), RARG(1), ROR1(1), THRA(1), THRB(2), VDR(2) 3152858 38 22 29 77 6 9 3 12 8 0 1.000 1.000 1.000 146 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 AKT2(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PITX2(1), PLD1(4), PLD2(13), VN1R1(9) 3441112 64 22 46 75 13 16 4 17 14 0 1.000 1.000 1.000 147 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 DUSP4(2), DUSP8(1), GAB1(1), IL1R1(1), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAPK7(1), MAPK8(1), NFATC3(1), PAPPA(4), TP53(6), TRAF6(1), ZAK(3) 3701842 35 22 32 54 13 9 2 8 3 0 1.000 1.000 1.000 148 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BIRC2(1), CASP8(3), MAP2K4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), RALBP1(1), TNF(3), TNFAIP3(8), TNFRSF1B(3) 2107986 36 22 34 27 5 6 2 9 14 0 1.000 1.000 1.000 149 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(4), CCND1(1), CCND2(2), CCND3(3), CSNK1E(1), DVL1(1), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), LDLR(3), MYC(7), PPP2R5E(1), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), RAC1(1), RHOA(2), SFRP4(2), TCF7(2), WNT10A(1), WNT16(4), WNT5A(1), WNT7B(1) 4287548 55 22 48 99 14 21 3 11 6 0 1.000 1.000 1.000 150 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 26 BRCA1(12), CCND1(1), CREBBP(7), EP300(5), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(3), HDAC2(2), HDAC6(2), MEF2C(1), NCOR2(9), NR0B1(2), NRIP1(3), PELP1(6), TBP(2) 3571992 58 21 48 66 14 18 5 13 8 0 1.000 1.000 1.000 151 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(15), CD3D(1), CD3G(2), GZMB(5), HLA-A(93), ICAM1(6), ITGAL(1), PRF1(2) 627337 125 21 86 62 12 38 7 55 12 1 0.979 1.000 1.000 152 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT1(1), AGPAT2(1), CDS1(1), CDS2(1), CHAT(4), CHKA(1), CLC(1), CPT1B(4), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), GNPAT(2), GPD1(1), GPD2(3), LCAT(1), LGALS13(1), LYPLA1(1), LYPLA2(1), PCYT1B(1), PEMT(4), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PPAP2B(1) 3794789 59 21 52 77 15 17 3 21 3 0 1.000 1.000 1.000 153 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(4), CCND1(1), DVL1(1), FZD1(1), GJA1(1), IRAK1(3), LBP(8), MYD88(7), NFKB1(3), PDPK1(1), PIK3CA(2), PPP2CA(1), TIRAP(5), TLR4(2) 2302812 40 21 30 46 7 15 4 5 9 0 1.000 1.000 1.000 154 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), AOX1(4), DBH(7), DCT(1), DDC(3), ECH1(2), ESCO1(1), FAH(1), GOT2(4), GSTZ1(3), HEMK1(1), HGD(1), LCMT1(1), LCMT2(1), METTL2B(3), PNPLA3(5), PRMT2(1), PRMT6(2), PRMT8(1), TAT(2), TH(3), TPO(10), TYR(9), TYRP1(1) 4353652 87 21 66 85 28 31 1 22 5 0 1.000 1.000 1.000 155 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT2(1), CASP9(4), KDR(8), KRAS(3), MAP2K1(2), MAPK11(1), MAPKAPK2(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PPP3CA(1), PPP3CC(1), PRKCG(2), PTGS2(1), PTK2(2), RAC1(1), RAC3(1), RAF1(4), SH2D2A(2), SHC2(1), SPHK1(1), SPHK2(1) 5424380 72 21 63 113 20 21 6 22 3 0 1.000 1.000 1.000 156 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(1), ADCY8(1), CACNA1A(3), CACNA1B(7), GNAS(1), GNAT3(1), GNB3(1), GRM4(1), ITPR3(2), KCNB1(1), PRKACA(1), PRKACG(2), PRKX(1), SCNN1A(3), SCNN1B(3), SCNN1G(2), TAS1R1(3), TAS1R2(10), TAS1R3(1), TAS2R1(3), TAS2R14(2), TAS2R16(3), TAS2R38(2), TAS2R39(1), TAS2R4(5), TAS2R40(1), TAS2R41(2), TAS2R42(6), TAS2R43(4), TAS2R46(3), TAS2R5(3), TAS2R50(3), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(12) 4332525 102 21 75 100 28 35 0 26 13 0 1.000 1.000 1.000 157 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CLK2(2), COL2A1(3), CPSF1(3), DDX20(9), DHX38(1), DHX9(1), DICER1(1), GIPC1(3), METTL3(1), NXF1(3), PRPF18(1), PRPF4(1), PRPF4B(3), PTBP1(1), PTBP2(1), RBM17(1), RBM5(1), RNGTT(1), SF3A2(1), SF3B1(5), SNRPD2(1), SNRPE(1), SPOP(1), SRPK1(1), SRRM1(2), SUPT5H(1) 7805498 51 21 44 144 9 24 1 7 10 0 1.000 1.000 1.000 158 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT2(1), BRD4(2), CBL(1), CDKN2A(1), F2RL2(1), GRB2(1), IGFBP1(2), INPPL1(1), IRS1(2), IRS2(2), IRS4(6), LNPEP(3), PARD3(2), PIK3CA(2), PIK3CD(1), PTEN(2), PTPN1(1), RAF1(4), RPS6KA1(2), RPS6KA2(1), SERPINB6(1), SFN(2), SLC2A4(1), SORBS1(4), SOS1(1), SOS2(1), YWHAE(1) 4329199 49 21 43 77 6 24 2 11 6 0 1.000 1.000 1.000 159 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ANGPTL2(1), DGKA(1), GCA(1), ITGA9(2), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), MAP2K1(2), PDE3A(9), PI3(6), PIK3C2G(10), PIK3CA(2), PIK3CD(1), RIPK3(4) 3650365 59 21 47 83 18 12 4 17 8 0 1.000 1.000 1.000 160 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3D(1), CD3G(2), ELK1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIA(3), PIK3CA(2), PLCG1(3), PPP3CA(1), PPP3CC(1), PTPN7(1), RAC1(1), RAF1(4), RASA1(2), SOS1(1), VAV1(3), ZAP70(1) 3519620 52 21 46 50 10 18 5 11 8 0 1.000 1.000 1.000 161 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(4), BTRC(1), CCND1(1), CREBBP(7), CSNK1A1(2), CSNK2A1(4), DVL1(1), FZD1(1), MYC(7), PPP2CA(1) 2234633 29 21 29 34 2 8 2 10 7 0 1.000 1.000 1.000 162 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CD3D(1), CD3G(2), CREBBP(7), CSK(3), GNAS(1), GNGT1(1), HLA-DRA(2), HLA-DRB1(46), PRKACG(2), PTPRC(1), ZAP70(1) 1715091 67 20 52 46 9 22 2 27 7 0 1.000 1.000 1.000 163 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(3), ATM(8), BRCA1(12), CDKN1A(4), CHEK2(2), MAPK8(1), NFKB1(3), NFKBIA(3), RAD50(1), TP53(6), TP73(1) 2158141 44 20 36 29 7 21 5 4 6 1 0.983 1.000 1.000 164 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CD3D(1), CD3G(2), CREBBP(7), CSK(3), GNAS(1), GNGT1(1), HLA-DRA(2), HLA-DRB1(46), PRKACG(2), PTPRC(1), ZAP70(1) 1715091 67 20 52 46 9 22 2 27 7 0 1.000 1.000 1.000 165 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(8), ATR(6), BRCA1(12), CDC25C(4), CDKN1A(4), CHEK2(2), EP300(5), MYT1(1), RPS6KA1(2), TP53(6) 3146291 50 20 38 39 10 22 4 11 2 1 0.999 1.000 1.000 166 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(4), ACP2(3), ACP5(1), ACPT(8), ALPL(2), ALPP(13), ALPPL2(5), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A6(6), CYP2A7(8), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2D6(11), CYP2E1(1), CYP2F1(9), CYP2J2(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(4), PON1(6) 2173728 118 20 81 53 32 33 3 36 14 0 0.786 1.000 1.000 167 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(1), CDA(2), CTPS2(1), DCK(1), DHODH(1), DPYD(9), DPYS(1), ENTPD3(3), ENTPD4(2), ENTPD5(2), ENTPD6(4), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4), PRIM1(1), RFC5(1), RRM1(1), UMPS(2), UPP1(1), UPP2(4) 6027791 66 20 54 137 20 22 2 21 1 0 1.000 1.000 1.000 168 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(12), CHIT1(11), CTBS(4), CYB5R1(1), CYB5R3(1), GFPT1(1), GFPT2(2), HEXB(5), HK1(1), HK2(4), HK3(1), MTMR1(3), MTMR2(4), NANS(3), NPL(1), PGM3(1), PHPT1(1), UAP1(1) 2117481 58 20 39 63 10 22 0 18 8 0 1.000 1.000 1.000 169 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTB(5), ACTG1(6), ARHGEF2(2), CDH1(1), CTTN(1), EZR(1), HCLS1(7), NCK1(2), NCL(4), RHOA(2), ROCK2(2), TLR4(2), TLR5(4), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3D(4), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5), WAS(1), WASL(1) 3841125 77 20 61 97 27 16 0 17 17 0 1.000 1.000 1.000 170 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTB(5), ACTG1(6), ARHGEF2(2), CDH1(1), CTTN(1), EZR(1), HCLS1(7), NCK1(2), NCL(4), RHOA(2), ROCK2(2), TLR4(2), TLR5(4), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3D(4), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5), WAS(1), WASL(1) 3841125 77 20 61 97 27 16 0 17 17 0 1.000 1.000 1.000 171 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 BCL2(1), CBL(1), E2F1(2), GRB2(1), IL2RA(1), IL2RB(2), IRS1(2), JAK1(2), JAK3(2), MYC(7), NMI(1), PIK3CA(2), PTPN6(4), RAF1(4), SOCS1(9), SOCS3(1), SOS1(1) 2671180 43 20 42 72 8 18 1 9 7 0 1.000 1.000 1.000 172 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(3), ACTN2(1), BCAR1(2), BCR(1), CAV1(1), CSK(3), GRB2(1), ITGA1(3), MAP2K1(2), MAPK8(1), PPP1R12B(1), PTK2(2), RAF1(4), SOS1(1), TLN1(6) 3511825 32 20 28 55 5 11 3 8 5 0 1.000 1.000 1.000 173 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), ELK1(1), GRB2(1), JAK1(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1), STAT3(8) 2568059 40 20 37 44 3 20 6 6 5 0 1.000 1.000 1.000 174 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(7), PML(2), RB1(1), SIRT1(2), SP100(5), TNF(3), TNFRSF1B(3), TP53(6) 1401040 29 20 26 21 5 8 2 6 8 0 0.989 1.000 1.000 175 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(6), AMY2A(1), AMY2B(2), ENPP1(3), ENPP3(3), GAA(1), GANAB(3), GBE1(3), GUSB(1), GYS2(2), HK1(1), HK2(4), HK3(1), MGAM(12), PGM1(4), PGM3(1), PYGB(6), PYGL(4), SI(5), UCHL1(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2), UXS1(1) 4897742 96 20 69 99 13 32 4 39 8 0 1.000 1.000 1.000 176 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 BCL2(1), EGFR(4), MYC(7), PPP2CA(1), RB1(1), TEP1(24), TERT(1), TNKS(2), TP53(6), XRCC5(2) 2032822 49 20 39 59 13 17 3 12 4 0 1.000 1.000 1.000 177 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP2(1), CASP8(3), DFFA(1), LMNA(3), MADD(6), MAP2K4(1), MAP3K1(7), MAPK8(1), PAK2(11), RB1(1), SPTAN1(1), TNF(3) 2935882 39 20 27 52 8 8 5 11 7 0 1.000 1.000 1.000 178 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(1), IKBKAP(11), IKBKB(2), LTA(5), MAP3K1(7), NFKB1(3), NFKBIA(3), TANK(2), TNFAIP3(8), TNFRSF1B(3), TRAF1(2), TRAF3(4) 1700324 51 20 39 30 10 18 0 11 12 0 0.993 1.000 1.000 179 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 ATM(8), BCL2(1), CASP7(3), CASP9(4), PTK2(2), STAT1(1), TLN1(6), TP53(6) 1997731 31 19 24 31 5 15 1 5 5 0 1.000 1.000 1.000 180 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 BTG1(9), CLDN5(2), CLOCK(2), EIF4G2(1), ETV6(1), GFRA1(1), GSTM3(3), GSTP1(1), HERPUD1(2), MYF6(1), NCKAP1(2), PER1(4), PER2(4), PIGF(1), UCP3(1), ZFR(2) 2694357 37 19 30 53 6 16 0 6 8 1 1.000 1.000 1.000 181 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C9(2), MASP1(1), MASP2(4), MBL2(4) 2551455 53 19 42 35 12 21 0 18 2 0 0.994 1.000 1.000 182 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(2), CASP7(3), CASP8(3), DFFA(1), FAF1(1), LMNA(3), MAP2K4(1), MAP3K1(7), MAPK8(1), PAK2(11), PTPN13(8), RB1(1), RIPK2(1), SPTAN1(1) 3154006 44 19 32 55 5 13 5 16 5 0 1.000 1.000 1.000 183 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(3), ATM(8), ATR(6), CCNA1(1), CCND1(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), E2F1(2), RB1(1), SKP2(1), TGFB2(1), TP53(6) 2204101 37 19 32 30 11 13 1 6 6 0 0.999 1.000 1.000 184 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(2), GRB2(1), INSR(2), IRS1(2), JAK2(2), MAP2K1(2), PIK3CA(2), PLCG1(3), PTPN6(4), RAF1(4), RPS6KA1(2), SLC2A4(1), SOCS1(9), SOS1(1) 2443030 39 19 37 53 4 17 3 8 7 0 1.000 1.000 1.000 185 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(1), ATP5F1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), COX10(3), COX4I2(2), COX7B(1), NDUFA2(1), NDUFA6(4), NDUFA9(1), NDUFS1(1), NDUFS2(3), NDUFS4(1), NDUFS7(1), NDUFV2(4), PPA2(4), SDHA(6), SDHC(1), TCIRG1(2), UQCRC1(1), UQCRH(2) 4188997 57 19 43 81 18 16 1 19 3 0 1.000 1.000 1.000 186 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(2), CSF2(1), HLA-DRA(2), HLA-DRB1(46), IFNA1(2), IL11(1), IL12B(2), IL1A(2), IL3(3), IL6(2), LTA(5), TGFB2(1), TNF(3) 1000891 72 19 52 43 12 28 3 26 3 0 0.979 1.000 1.000 187 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(3), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(3), CHRM3(5), DRD2(1), DRD3(1), DRD5(5), HRH1(1), HRH2(1), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1) 1909000 35 19 32 47 5 8 4 17 1 0 1.000 1.000 1.000 188 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(1), CREBBP(7), EP300(5), IKBKB(2), NFKB1(3), NFKBIA(3), TNF(3), TNFRSF1B(3), TRAF6(1) 1696262 28 19 25 19 4 8 0 8 8 0 0.992 1.000 1.000 189 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CCND1(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), E2F1(2), E2F2(3), PRB1(9), TP53(6) 608381 27 19 20 15 5 11 1 5 5 0 0.854 1.000 1.000 190 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 GORASP1(1), MAP2K4(1), MAPK11(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MAPKAPK5(2), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PIK3CA(2), PIK3CD(1), TRAF3(4), TRAF6(1) 2674923 34 19 31 29 7 11 3 5 8 0 1.000 1.000 1.000 191 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(2), DLG4(1), EPHB2(1), F2(1), F2RL2(1), F2RL3(1), MAPK7(1), MAPK8(1), PLD1(4), PLD2(13), PTK2(2), RAF1(4), RASAL1(4), TEC(2), VAV1(3) 2044240 41 19 30 30 8 12 4 9 8 0 0.993 1.000 1.000 192 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT2(1), ARHGEF11(4), BCL2(1), DLG4(1), GNA13(2), LPA(10), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PI3(6), PLD1(4), PLD2(13), PTK2(2), ROCK2(2) 3770778 72 19 54 51 17 13 7 22 13 0 1.000 1.000 1.000 193 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNGR2(2), IKBKB(2), JAK2(2), NFKB1(3), NFKBIA(3), RB1(1), TNF(3), TNFRSF1B(3), TP53(6), USH1C(1) 1412787 26 19 23 27 4 7 0 7 8 0 1.000 1.000 1.000 194 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(4), GRB2(1), JAK2(2), MAP2K1(2), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1), STAT3(8) 2194838 30 19 28 28 1 14 4 7 4 0 1.000 1.000 1.000 195 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(4), ARSB(5), ARSD(19), ARSE(1), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2) 1966703 70 18 46 66 14 20 3 31 2 0 1.000 1.000 1.000 196 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(1), IKBKAP(11), IKBKB(2), MAP3K1(7), NFKB1(3), NFKBIA(3), TNFAIP3(8), TRAF3(4), TRAF6(1) 1392952 40 18 32 24 7 15 0 7 11 0 0.995 1.000 1.000 197 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CXCR4(4), GNGT1(1), MAP2K1(2), NFKB1(3), PIK3C2G(10), PIK3CA(2), PLCG1(3), PTK2(2), PTK2B(4), RAF1(4) 2083046 37 18 31 47 9 11 3 8 6 0 1.000 1.000 1.000 198 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOB(1), ALDOC(1), FBP2(2), FPGT(1), FUK(3), GMPPB(2), HK1(1), HK2(4), HK3(1), HSD3B7(2), KHK(3), MTMR1(3), MTMR2(4), PFKM(1), PHPT1(1), PMM2(1), RDH12(3), SORD(5) 2779768 39 18 30 76 15 9 0 13 2 0 1.000 1.000 1.000 199 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH4(4), ADH7(2), ADHFE1(1), AGPAT1(1), AGPAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CEL(4), DAK(2), DGAT1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), GLB1(1), GPAM(5), LCT(3), LIPA(3), LIPC(3), LIPF(2), LIPG(4), LPL(1), PNLIPRP1(4), PNPLA3(5), PPAP2B(1) 4395822 81 18 64 107 9 32 4 28 8 0 1.000 1.000 1.000 200 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(2), ACACB(12), ACAT1(2), ACAT2(1), ACOT12(3), ACSS1(2), ACSS2(1), ACYP1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DLAT(1), GLO1(2), GRHPR(4), LDHA(1), LDHAL6A(2), LDHAL6B(7), MDH2(5), ME2(2), ME3(2), PC(1), PCK1(3), PCK2(1), PDHA2(2) 3395782 71 18 57 91 21 27 3 17 3 0 1.000 1.000 1.000 201 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS2(1), BLVRA(1), COX10(3), CP(1), CPOX(1), EPRS(2), GUSB(1), HMOX1(3), MMAB(5), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2A1(9), UGT2B11(9), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), UROS(1) 2938763 84 18 58 79 12 26 2 39 5 0 1.000 1.000 1.000 202 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22RA1(2), IL22RA2(2), JAK1(2), JAK2(2), JAK3(2), SOCS3(1), STAT1(1), STAT3(8), TYK2(3) 1400196 27 18 26 30 5 5 4 11 2 0 1.000 1.000 1.000 203 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(7), EP300(5), IL7R(7), JAK1(2), JAK3(2), NMI(1), PIK3CA(2), PTK2B(4) 2069090 31 18 25 38 7 12 0 6 6 0 1.000 1.000 1.000 204 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(8), CCND2(2), CDKN1B(1), EGR1(1), ESR2(1), FSHR(5), GJA4(5), INHA(4), LHCGR(3), MLH1(5), MSH5(4), NCOR1(5), NRIP1(3), PGR(7), PRLR(2), VDR(2), ZP2(3) 2543618 61 18 46 46 4 38 1 17 1 0 0.998 1.000 1.000 205 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(3), ALOX15(2), CBR3(4), CYP4F2(4), CYP4F3(1), EPX(3), GGT1(6), LPO(2), LTA4H(2), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PTGES2(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5), TPO(10) 2096266 58 18 46 61 15 16 4 22 1 0 1.000 1.000 1.000 206 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(2), ARHGAP5(2), ARHGAP6(2), ARHGEF1(1), ARHGEF11(4), ARHGEF5(8), ARPC1B(3), BAIAP2(4), GSN(4), LIMK1(1), MYLK(8), PFN1(3), PIP5K1A(1), PIP5K1B(1), PPP1R12B(1), TLN1(6) 3532824 51 18 37 27 9 12 7 14 9 0 0.894 1.000 1.000 207 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(4), ASAH1(4), CERK(2), CXCL2(1), EPHB2(1), ITPKA(1), ITPKB(10), MAP2K4(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2) 2114383 29 18 23 32 5 13 2 6 3 0 1.000 1.000 1.000 208 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 ATF1(1), CASP2(1), CHUK(1), IKBKB(2), LTA(5), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), NFKB1(3), NFKBIA(3), TANK(2), TNF(3) 1841230 34 18 30 24 7 9 3 6 9 0 0.992 1.000 1.000 209 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(2), AOC3(4), AOX1(4), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A6(6), CYP2A7(8), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2D6(11), CYP2E1(1), CYP2F1(9), CYP2J2(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(4), DDC(3), ECHS1(1), EHHADH(3), HAAO(1), KYNU(1), TDO2(1), WARS2(1) 4022322 114 18 91 78 31 37 2 31 13 0 1.000 1.000 1.000 210 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF2B3(2), EIF2B4(2), EIF2B5(4), EIF2S2(1), EIF2S3(2), ELAVL1(1), FLT1(2), FLT4(5), KDR(8), PIK3CA(2), PLCG1(3), PTK2(2) 2546146 35 18 30 40 5 13 3 14 0 0 1.000 1.000 1.000 211 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(3), CDKN2A(1), E2F1(2), MYC(7), PIK3CA(2), POLR1A(3), POLR1B(2), RAC1(1), RB1(1), TP53(6) 1470999 28 17 28 36 8 8 2 6 4 0 1.000 1.000 1.000 212 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(2), EGFR(4), ELK1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), MEF2B(3), MEF2C(1), PTK2(2), PTK2B(4), RAC1(1), RAF1(4), SOS1(1) 2511670 39 17 33 58 9 13 3 8 6 0 1.000 1.000 1.000 213 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(1), GNAS(1), GNGT1(1), LIMK1(1), MAP2K1(2), PIK3C2G(10), PLCB1(8), PPP1R12B(1), PTK2(2), RAF1(4), ROCK2(2) 1878938 34 17 29 28 9 7 1 10 7 0 1.000 1.000 1.000 214 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 MAP2K1(2), MYC(7), NFKB1(3), NFKBIA(3), PLCB1(8), RAF1(4), TNF(3) 1124288 30 17 27 28 2 8 2 8 10 0 1.000 1.000 1.000 215 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C9(2) 2264301 44 17 34 32 8 18 0 17 1 0 0.997 1.000 1.000 216 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C8B(3), C9(2), MASP1(1) 2500893 48 17 37 32 8 21 0 18 1 0 0.993 1.000 1.000 217 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(2), GSN(4), ITGA1(3), MAP2K1(2), MYLK(8), PFN1(3), PIK3CA(2), PTK2(2), RAF1(4), TLN1(6) 2752225 36 17 31 32 7 10 3 11 5 0 1.000 1.000 1.000 218 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), GOT2(4), HK1(1), HK2(4), HK3(1), LDHA(1), LDHAL6B(7), MDH2(5), PC(1), PCK1(3), PDHA2(2), PDHX(3), PFKM(1), PGAM2(1), PGK2(1) 3067490 43 17 32 82 10 19 2 9 3 0 1.000 1.000 1.000 219 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(4), CALCR(5), CALCRL(2), CD97(2), CRHR1(1), ELTD1(7), EMR1(17), EMR2(4), GHRHR(2), GIPR(1), GLP1R(3), GLP2R(3), LPHN1(1), LPHN2(3), LPHN3(1), SCTR(1), VIPR2(1) 2053320 58 17 42 35 13 20 5 18 2 0 0.970 1.000 1.000 220 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(1), ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH7A1(1), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), G6PC2(6), GALM(2), HK1(1), HK2(4), HK3(1), LDHA(1), LDHAL6A(2), LDHAL6B(7), PDHA2(2), PFKM(1), PGAM2(1), PGAM4(1), PGK2(1), PGM1(4), PGM3(1) 4254169 71 17 54 106 15 26 2 22 6 0 1.000 1.000 1.000 221 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(1), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2A1(9), UGT2B11(9), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), XYLB(3) 1851875 65 17 45 53 5 22 2 31 5 0 1.000 1.000 1.000 222 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(3), ACAA2(3), ACADL(3), ACADM(1), ACADS(1), ACADSB(2), ACADVL(1), ACAT1(2), ACAT2(1), ACOX1(7), ACOX3(1), ACSL3(2), ACSL5(2), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CPT1B(4), CPT1C(1), CPT2(5), CYP4A11(4), CYP4A22(19), ECHS1(1), EHHADH(3), HADHB(1), HSD17B4(4) 3583464 92 17 66 62 16 34 7 29 6 0 1.000 1.000 1.000 223 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(6), ALG10(1), ALG11(1), ALG12(1), ALG14(2), ALG3(1), ALG6(4), ALG8(3), ALG9(1), B4GALT2(1), B4GALT3(2), DHDDS(3), DOLPP1(1), DPAGT1(2), FUT8(4), GANAB(3), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(1), MGAT1(6), MGAT4A(2), MGAT5(1), MGAT5B(2), RFT1(1), RPN2(1), ST6GAL1(3), STT3B(1) 3152563 57 17 48 58 15 22 3 14 3 0 1.000 1.000 1.000 224 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT2(1), BRAF(3), PDPK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PRKAA1(1), RICTOR(4), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1), RPS6KB2(5), STK11(1), TSC1(4), ULK1(3), ULK2(1), ULK3(3), VEGFB(1), VEGFC(2) 4010905 42 17 36 76 11 15 1 8 7 0 1.000 1.000 1.000 225 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(2), AGT(4), AGTR1(2), AGTR2(3), ANPEP(4), CMA1(1), CTSG(1), ENPEP(2), LNPEP(3), MAS1(1), MME(4), NLN(4), THOP1(1) 1540715 34 17 32 17 8 11 1 10 4 0 0.811 1.000 1.000 226 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(4), ABCG2(3), BCHE(3), CES1(12), CYP3A4(1), CYP3A5(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3) 1661311 53 17 36 42 10 18 1 17 7 0 1.000 1.000 1.000 227 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(5), C5(6), C6(3), C7(7), ICAM1(6), IL1A(2), IL6(2), ITGA4(5), ITGAL(1), SELP(6), SELPLG(9), TNF(3), VCAM1(1) 1800032 56 17 41 57 12 13 0 25 5 1 1.000 1.000 1.000 228 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(3), CCR1(1), CCR2(3), CCR3(1), CSF2(1), CXCR4(4), IFNGR2(2), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), IL4R(15), TGFB2(1) 1470755 44 17 30 43 8 14 8 13 1 0 1.000 1.000 1.000 229 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), ATP7A(1), ATP7B(1), COX10(3), COX7B(1), NDUFS1(1), NDUFS2(3), NDUFV2(4), PPA2(4), SDHA(6), SHMT1(3), UQCRC1(1), UQCRH(2) 2813214 44 17 34 64 11 12 1 19 1 0 1.000 1.000 1.000 230 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(6), ATM(8), CDKN1A(4), CPB2(2), CSNK1A1(2), IGFBP3(1), MAPK8(1), NFKBIB(1), NQO1(4), TP53(6) 1594294 35 17 28 21 5 19 1 6 4 0 0.920 1.000 1.000 231 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 ATM(8), BCL2(1), CCND1(1), CDKN1A(4), E2F1(2), RB1(1), TP53(6) 1324334 23 17 20 22 5 10 0 3 5 0 0.998 1.000 1.000 232 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(2), ACAT1(2), ACAT2(1), ACYP1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DLAT(1), GLO1(2), GRHPR(4), LDHA(1), MDH2(5), ME2(2), ME3(2), PC(1), PCK1(3), PDHA2(2) 2693336 43 17 38 65 8 17 2 14 2 0 1.000 1.000 1.000 233 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT2(1), BCL2(1), GRB2(1), IL4R(15), IRS1(2), IRS2(2), JAK1(2), JAK3(2), MAP4K1(1), PIK3CA(2), PIK3CD(1), RAF1(4), SOCS1(9), SOS1(1), SOS2(1), STAT6(4) 2709873 49 17 41 60 8 24 6 6 5 0 1.000 1.000 1.000 234 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), APC(4), ASAH1(4), DLG4(1), EPHB2(1), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PITX2(1), PTX3(3), RAC1(1), RYR1(4) 3412968 33 17 29 108 8 10 3 10 2 0 1.000 1.000 1.000 235 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), AOX1(4), DBH(7), DCT(1), DDC(3), FAH(1), GOT2(4), GSTZ1(3), HGD(1), TAT(2), TH(3), TPO(10), TYR(9) 2336738 68 17 50 65 25 22 1 16 4 0 1.000 1.000 1.000 236 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(4), AGTR1(2), AGTR2(3), CMA1(1), COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1) 1880144 44 16 35 38 11 12 1 15 5 0 0.999 1.000 1.000 237 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(4), ELK1(1), EPOR(1), GRB2(1), JAK2(2), MAP2K1(2), MAPK8(1), PLCG1(3), PTPN6(4), RAF1(4), SOS1(1) 1616140 24 16 23 17 2 10 4 4 4 0 0.971 1.000 1.000 238 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH4(4), ADH7(2), ADHFE1(1), AGPAT1(1), AGPAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), CEL(4), DGAT1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), GLB1(1), LCT(3), LIPC(3), LIPF(2), LIPG(4), LPL(1), PNLIPRP1(4), PPAP2B(1) 3629870 61 16 49 91 10 24 4 16 7 0 1.000 1.000 1.000 239 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS2(3), ACY3(1), ADSS(1), ADSSL1(3), AGXT(1), AGXT2(4), ASS1(1), CAD(1), DARS2(1), DDO(1), DLAT(1), GAD1(2), GAD2(1), GOT2(4), GPT(1), NARS2(1), PC(1), PDHA2(2) 2795367 30 16 26 49 10 6 2 12 0 0 1.000 1.000 1.000 240 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DOT1L(2), ECHS1(1), EHHADH(3), EHMT1(1), EHMT2(2), HSD17B4(4), HSD3B7(2), NSD1(6), OGDH(2), OGDHL(3), PIPOX(1), PLOD1(2), PLOD2(2), RDH12(3), SETD1A(1), SHMT1(3), SHMT2(1), SPCS1(1), SUV39H1(1), SUV39H2(1) 4262125 63 16 56 79 15 26 2 17 3 0 1.000 1.000 1.000 241 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT2(3), COASY(4), DPYD(9), DPYS(1), ENPP1(3), ENPP3(3), PANK1(1), PANK2(1), PANK4(5), VNN1(9) 1282087 39 16 28 19 4 15 5 13 2 0 0.805 1.000 1.000 242 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), ARSB(5), FUCA1(2), FUCA2(8), GALNS(2), GBA(2), GLB1(1), GUSB(1), HEXB(5), HGSNAT(1), HPSE(2), HPSE2(6), IDS(1), IDUA(5), LCT(3), MAN2B1(10), MAN2B2(10), MANBA(7), NAGLU(3), NEU2(3), NEU4(4) 2626601 83 16 51 66 30 28 5 18 2 0 1.000 1.000 1.000 243 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), CAMK2G(1), CLCA1(2), CLCA2(10), CLCA4(6), CNGA4(3), CNGB1(4), GUCA1C(8), PDE1C(5), PRKACA(1), PRKACG(2), PRKG1(3), PRKG2(1), PRKX(1) 2276287 49 16 37 73 5 26 1 11 6 0 1.000 1.000 1.000 244 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), BAIAP2(4), CASP1(1), CASP7(3), CASP8(3), INSR(2), ITCH(1), MAGI1(3), MAGI2(4), RERE(2), WWP2(1) 1743666 26 16 21 58 1 7 4 11 3 0 1.000 1.000 1.000 245 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(6), ADCY3(2), ADCY9(4), AK1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), GNAS(1), PDIA4(2), PLCG1(3), PLCG2(5), SEC61A1(1), SEC61A2(1), TRIM23(1) 2726736 39 16 35 57 11 12 4 7 5 0 1.000 1.000 1.000 246 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), HMOX1(3), IL10RA(4), IL10RB(2), IL1A(2), IL6(2), JAK1(2), STAT1(1), STAT3(8), TNF(3) 895076 28 16 25 26 4 9 3 10 2 0 0.999 1.000 1.000 247 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(5), DLAT(1), IDH3A(1), IDH3B(1), MDH2(5), OGDH(2), PC(1), PDHA2(2), PDHX(3), SDHA(6), SDHC(1), SUCLG2(1) 2087926 29 16 22 43 8 9 2 6 4 0 1.000 1.000 1.000 248 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ELK1(1), GRB2(1), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPKAPK2(1), MAPKAPK5(2), MEF2B(3), MEF2C(1), MKNK1(1), MYC(7), PLA2G4A(1), RAC1(1), RPS6KA5(1), STAT1(1), TGFB2(1) 2755235 31 16 29 53 5 11 2 8 5 0 1.000 1.000 1.000 249 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(4), DPYD(9), DPYS(1), ENPP1(3), ENPP3(3), PANK1(1), PANK2(1), PANK4(5) 1032407 27 16 20 16 4 9 5 8 1 0 0.916 1.000 1.000 250 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(8), ATR(6), CDC25C(4), CHEK2(2), TP53(6) 1143073 26 16 21 10 8 11 0 4 2 1 0.696 1.000 1.000 251 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(1), CDA(2), CTPS2(1), DCK(1), DHODH(1), DPYD(9), DPYS(1), NT5C(1), NT5E(2), NT5M(1), POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15), POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4), RRM1(1), UMPS(2), UPP1(1) 4277682 56 16 47 109 10 25 3 17 1 0 1.000 1.000 1.000 252 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5R1(1), LIMK1(1), MAP3K1(7), MYLK(8), NCF2(2), PIK3CA(2), PLD1(4), PPP1R12B(1), RAC1(1), RALBP1(1), TRIO(3), VAV1(3), WASF1(1) 2554515 35 16 29 32 9 8 4 11 3 0 1.000 1.000 1.000 253 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(1), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP3K1(7), MAPK8IP3(2), PAPPA(4), RAC1(1), RPS6KA1(2), SOS1(1), VAV1(3), VAV2(3), VAV3(4) 2369020 34 16 29 63 8 13 1 9 3 0 1.000 1.000 1.000 254 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(1), CISH(1), GRB2(1), IARS(2), IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), JAK3(2), PI3(6), PIK3CA(2), SOS1(1), SOS2(1), STAT6(4), TYK2(3) 2707386 44 16 33 41 10 14 6 13 1 0 1.000 1.000 1.000 255 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(2), JAK1(2), JAK2(2), JAK3(2), PTPRU(4), STAT3(8) 1138001 23 16 21 17 5 6 1 10 1 0 0.989 1.000 1.000 256 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT2(1), ANKRD6(3), APC(4), AXIN2(4), CER1(4), CSNK1A1(2), DACT1(7), DKK2(2), DVL1(1), LRP1(6), MVP(2), NKD2(2), PSEN1(1), PTPRA(2), SENP2(1) 3007405 42 16 33 55 14 18 0 8 2 0 1.000 1.000 1.000 257 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRA(2), HLA-DRB1(46), IFNGR2(2), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), IL2RA(1), IL4R(15) 915108 80 16 54 48 10 31 8 27 4 0 0.995 1.000 1.000 258 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADL(3), ACADM(1), ACADSB(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DPYD(9), DPYS(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1) 2109652 51 15 42 40 10 22 1 14 4 0 1.000 1.000 1.000 259 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 21 F10(1), F11(1), F12(1), F13B(1), F2(1), F5(18), F7(3), F8(3), F9(1), FGA(2), FGB(1), FGG(1), LPA(10), PLAT(1), PLG(4), SERPINB2(4), SERPINE1(1), SERPINF2(8), VWF(11) 2649739 73 15 51 85 21 31 0 18 3 0 1.000 1.000 1.000 260 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), AGT(4), AGTR2(3), EDN1(3), EDNRA(1), EGF(4), EGFR(4), MYC(7), NFKB1(3), PLCG1(3) 1485033 33 15 26 40 5 10 3 13 2 0 1.000 1.000 1.000 261 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A2(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(2), MKNK1(1), PABPC1(23), PDPK1(1), PIK3CA(2), PTEN(2) 2077640 39 15 33 35 10 9 1 12 7 0 1.000 1.000 1.000 262 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCL2(1), BCR(1), GRB2(1), JAK2(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), MYC(7), PIK3CA(2), RAF1(4), SOS1(1), STAT1(1) 2025614 31 15 30 46 3 14 4 8 2 0 1.000 1.000 1.000 263 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), HK1(1), HK2(4), HK3(1), LDHA(1), PDHA2(2), PFKM(1), PGM1(4), PGM3(1) 3563180 48 15 41 89 10 21 2 11 4 0 1.000 1.000 1.000 264 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(4), G6PD(1), GGT1(6), GPX5(1), GSTA2(7), GSTA3(2), GSTA4(1), GSTM3(3), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), GSTZ1(3), IDH1(1), PGD(1) 1402190 36 15 23 28 6 17 2 9 1 1 0.993 1.000 1.000 265 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AGXT2(4), ALAS2(1), AMT(1), AOC2(2), AOC3(4), BHMT(1), CBS(2), CHKA(1), CPT1B(4), CTH(2), DAO(2), DMGDH(4), GAMT(1), GARS(1), GCAT(3), PEMT(4), PLCG1(3), PLCG2(5), PSPH(13), SARDH(2), SARS(1), SHMT1(3), SHMT2(1) 3139026 66 15 49 86 22 24 3 15 2 0 1.000 1.000 1.000 266 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), HK1(1), HK2(4), HK3(1), LDHA(1), PDHA2(2), PFKM(1), PGM1(4), PGM3(1) 3563180 48 15 41 89 10 21 2 11 4 0 1.000 1.000 1.000 267 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(4), CAMK1G(1), INSR(2), MAPK7(1), MEF2B(3), MEF2C(1), NFATC1(6), NFATC2(2), PIK3CA(2), PPP3CA(1), PPP3CC(1) 2582756 24 15 21 54 7 6 0 8 3 0 1.000 1.000 1.000 268 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), CLYBL(4), CS(5), IDH1(1), IDH3A(1), IDH3B(1), MDH2(5), OGDH(2), OGDHL(3), PC(1), PCK1(3), PCK2(1), SDHA(6), SDHC(1), SUCLG2(1) 2163943 37 15 28 51 8 12 1 11 5 0 1.000 1.000 1.000 269 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), ALDOC(1), DERA(1), FBP2(2), G6PD(1), H6PD(3), PFKM(1), PGD(1), PGM1(4), PGM3(1), PRPS1L1(2), TKT(1), TKTL2(2) 1789884 21 15 18 51 6 10 1 4 0 0 1.000 1.000 1.000 270 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(5), CYP2A6(6), CYP2A7(8), NAT1(1), NAT2(7), XDH(6) 583688 35 15 23 25 5 16 2 7 5 0 0.968 1.000 1.000 271 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AGXT2(4), ALAS2(1), AMT(1), AOC2(2), AOC3(4), BHMT(1), CBS(2), CHKA(1), CTH(2), DAO(2), DMGDH(4), GAMT(1), GARS(1), GCAT(3), HSD3B7(2), PEMT(4), PIPOX(1), PSPH(13), RDH12(3), SARDH(2), SARS(1), SHMT1(3), SHMT2(1) 3194363 60 15 43 80 24 23 1 11 1 0 1.000 1.000 1.000 272 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(3), ACAA2(3), ACADM(1), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOX1(4), BCAT2(3), BCKDHA(1), BCKDHB(1), DBT(1), ECHS1(1), EHHADH(3), HADHB(1), HIBCH(2), HMGCS2(1), HSD17B4(4), MCCC1(6), MCCC2(1), MCEE(5), MUT(5), OXCT1(2), OXCT2(2), PCCA(1), PCCB(1) 3223373 70 15 58 51 17 24 3 19 7 0 1.000 1.000 1.000 273 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ASS1(1), CKM(1), CPS1(5), DAO(2), EPRS(2), GAMT(1), GOT2(4), LAP3(1), NOS1(3), OTC(4), P4HA3(2), PARS2(2), PRODH(4), PYCRL(5), RARS(2), RARS2(5) 2729647 46 15 35 53 10 19 2 13 2 0 1.000 1.000 1.000 274 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), DDC(3), EPX(3), ESCO1(1), GOT2(4), LPO(2), PNPLA3(5), TAT(2), TPO(10) 2500214 43 15 37 45 14 13 2 13 1 0 1.000 1.000 1.000 275 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ACAT1(2), ACAT2(1), AFMID(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), AOX1(4), CYP1A1(2), CYP1A2(2), CYP1B1(2), DDC(3), ECHS1(1), EHHADH(3), HAAO(1), HEMK1(1), HSD17B4(4), INMT(9), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL2B(3), OGDH(2), OGDHL(3), PRMT2(1), PRMT6(2), PRMT8(1), TDO2(1), WARS2(1) 4422017 74 15 65 76 19 29 3 20 3 0 1.000 1.000 1.000 276 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(2), CTH(2), GGT1(6), HEMK1(1), LCMT1(1), LCMT2(1), MAT2B(1), METTL2B(3), PAPSS1(5), PAPSS2(1), PRMT2(1), PRMT6(2), PRMT8(1), SCLY(3) 1834106 30 15 21 25 7 12 0 8 3 0 0.994 1.000 1.000 277 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(2), ACADS(1), ACAT1(2), ACAT2(1), ACSM1(3), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(3), ALDH7A1(1), ALDH9A1(3), BDH1(1), BDH2(2), DDHD1(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), HMGCS2(1), HSD17B4(4), HSD3B7(2), L2HGDH(1), OXCT1(2), OXCT2(2), PDHA2(2), PLA1A(2), RDH12(3) 3021343 57 15 49 62 11 23 3 14 6 0 1.000 1.000 1.000 278 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(3), B3GALNT1(3), B3GALT5(1), B3GNT1(1), B3GNT3(1), B3GNT4(2), B3GNT5(2), B4GALNT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT2(1), FUT3(6), FUT4(1), FUT5(6), FUT6(7), GBGT1(4), PIGB(4), PIGC(3), PIGF(1), PIGG(7), PIGK(1), PIGL(1), PIGM(2), PIGN(3), PIGP(2), PIGQ(4), PIGS(1), PIGZ(3), ST3GAL4(3), ST3GAL5(3), ST3GAL6(1), ST6GALNAC3(1) 3632832 86 15 61 103 16 38 3 22 7 0 1.000 1.000 1.000 279 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(3), GRB2(1), IL3(3), IL3RA(4), JAK2(2), MAP2K1(2), PTPN6(4), RAF1(4), SOS1(1) 1314470 24 15 19 18 3 9 1 9 2 0 0.987 1.000 1.000 280 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1), F10(1), F11(1), F12(1), F2(1), F2R(1), F5(18), F8(3), F9(1), FGA(2), FGB(1), FGG(1), KLKB1(4), PROC(2), PROS1(1), SERPINC1(1), SERPING1(1) 3290647 72 15 54 84 18 31 1 19 3 0 1.000 1.000 1.000 281 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(4), DPM2(1), ELK1(1), GRB2(1), KLK2(1), MAP2K1(2), MAPK8(1), NGFR(2), PIK3CA(2), PLCG1(3), RAF1(4), SOS1(1) 1403096 23 15 22 19 2 10 5 2 4 0 0.989 1.000 1.000 282 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), GRB2(1), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), PLCG1(3), PTK2B(4), RAC1(1), RAF1(4), SOS1(1) 2100377 31 15 27 48 6 11 6 2 6 0 1.000 1.000 1.000 283 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 ATF1(1), EEF2K(3), ELK1(1), IL1R1(1), MAP2K3(4), MAP2K4(1), MAP3K10(1), MAP3K4(1), MAP3K5(1), MAPK11(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(1), MKNK2(3), NFKB1(3), TRAF6(1) 2532189 26 15 25 34 8 5 2 4 7 0 1.000 1.000 1.000 284 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT2(1), BTK(2), CDKN2A(1), GRB2(1), IARS(2), IGFBP1(2), PIK3CA(2), PTEN(2), RPS6KA1(2), RPS6KA2(1), SFN(2), SOS1(1), SOS2(1), TEC(2), YWHAE(1) 2627883 23 15 19 45 1 9 2 5 6 0 1.000 1.000 1.000 285 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2G(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), NFAT5(1), PDE6A(1), PDE6C(1), PDE6H(1), SLC6A13(2), TF(2) 2666040 29 15 26 102 9 9 0 6 5 0 1.000 1.000 1.000 286 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(3), ACAA2(3), ACADL(3), ACADM(1), ACADS(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOX1(4), BCKDHA(1), BCKDHB(1), ECHS1(1), EHHADH(3), HADHB(1), MCCC1(6), MCCC2(1), MCEE(5), MUT(5), OXCT1(2), PCCA(1), PCCB(1) 2666035 62 15 51 46 16 22 1 16 7 0 1.000 1.000 1.000 287 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(1), EGR2(1), MAP3K1(7), MYC(7), NFATC1(6), NFATC2(2), NFKB1(3), NFKBIA(3), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKACG(2), VIPR2(1) 2047935 38 15 32 48 6 11 3 13 5 0 1.000 1.000 1.000 288 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(1), IKBKB(2), MAP3K1(7), MAP3K5(1), MAP4K5(3), MAPK8(1), NFKB1(3), NFKBIA(3), TNFSF9(1) 1462264 22 14 20 22 4 7 1 5 5 0 1.000 1.000 1.000 289 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(4), BMP10(3), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMPR1A(3), CHRD(4), DVL1(1), FZD1(1), GATA4(2), MEF2C(1), NKX2-5(1), NPPA(1), TGFB2(1), TGFBR3(2) 2695065 31 14 27 53 9 10 3 9 0 0 1.000 1.000 1.000 290 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(2), CR1(18), CR2(7), FCGR2B(1), HLA-DRA(2), HLA-DRB1(46), ICAM1(6), ITGAL(1), PTPRC(1) 1233667 84 14 54 39 7 37 3 31 6 0 0.888 1.000 1.000 291 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(3), ALDH9A1(3), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), L2HGDH(1), OXCT1(2), PDHA2(2) 1892140 34 14 31 41 6 14 2 9 3 0 1.000 1.000 1.000 292 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(1), CD3G(2), CD80(2), CD86(1), CTLA4(1), GRB2(1), HLA-DRA(2), HLA-DRB1(46), PIK3CA(2) 923199 58 14 44 30 5 25 1 23 4 0 0.965 1.000 1.000 293 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(2), IL12B(2), IL16(4), IL1A(2), IL3(3), IL6(2), IL9(1), LTA(5), TNF(3) 716613 24 14 18 20 8 10 0 5 1 0 0.991 1.000 1.000 294 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 BCL2(1), BIRC2(1), CASP10(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), LMNA(3), NFKB1(3), NFKBIA(3), SPTAN1(1), TNFRSF10A(7), TNFRSF10B(4) 2478464 37 14 27 48 6 15 1 9 6 0 1.000 1.000 1.000 295 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(5), CDT1(2), GMNN(1), MCM10(7), MCM3(2), MCM4(2), MCM5(3), MCM7(2), NACA(7), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), PRIM1(1), RFC4(2), RFC5(1), RPA4(2), UBB(1) 3749026 47 14 32 86 8 20 1 16 2 0 1.000 1.000 1.000 296 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15(2), ALOX15B(6), GGT1(6), LTA4H(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5) 1168123 29 14 23 35 7 5 3 11 3 0 1.000 1.000 1.000 297 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(2), ALDH5A1(3), CAD(1), CPS1(5), EPRS(2), GAD1(2), GAD2(1), GFPT1(1), GLS(1), GLS2(2), GMPS(1), GOT2(4), GPT(1), NADSYN1(1), QARS(1) 2439238 28 14 21 47 5 7 2 11 3 0 1.000 1.000 1.000 298 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(1), FDFT1(2), GGCX(2), GGPS1(1), HMGCR(1), HSD17B7(4), IDI2(2), LSS(3), MVK(2), NQO1(4), NSDHL(1), SQLE(1), TM7SF2(3) 1442027 27 14 21 46 7 12 2 3 3 0 1.000 1.000 1.000 299 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(3), ACAA2(3), ACAD8(1), ADH4(4), ADH7(2), ADHFE1(1), AKR1C4(4), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BAAT(4), CEL(4), CYP27A1(1), HADHB(1), HSD3B7(2), LIPA(3), RDH12(3), SLC27A5(8), SOAT1(1), SOAT2(3) 2344992 62 14 47 60 15 23 2 17 5 0 1.000 1.000 1.000 300 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(2), ALDH5A1(3), CAD(1), CPS1(5), EPRS(2), GAD1(2), GAD2(1), GFPT1(1), GFPT2(2), GLS(1), GLS2(2), GMPS(1), GOT2(4), GPT(1), NADSYN1(1), QARS(1) 2892271 30 14 22 57 5 9 2 11 3 0 1.000 1.000 1.000 301 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ACADM(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DPYD(9), DPYS(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), HIBCH(2), SRM(1) 1960112 49 14 41 36 9 21 1 14 4 0 0.999 1.000 1.000 302 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(4), G6PD(1), GGT1(6), GPX5(1), GSTA2(7), GSTA3(2), GSTA4(1), GSTM3(3), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), GSTZ1(3), IDH1(1), OPLAH(8) 1726611 43 14 27 31 11 16 3 11 1 1 0.993 1.000 1.000 303 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), CYP1A2(2), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2J2(1), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), HSD3B7(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), RDH12(3) 1787057 45 14 36 37 16 10 1 12 6 0 1.000 1.000 1.000 304 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), ALDOC(1), FBP2(2), GOT2(4), GPT(1), MDH2(5), ME3(2), PGK2(1), TKT(1), TKTL2(2) 1482453 20 14 17 30 4 7 1 8 0 0 1.000 1.000 1.000 305 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(4), ACP2(3), ACP5(1), ACP6(1), ACPT(8), ENPP1(3), ENPP3(3), FLAD1(1), MTMR1(3), MTMR2(4), PHPT1(1), TYR(9) 1116158 41 14 25 24 12 10 2 14 3 0 0.962 1.000 1.000 306 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(5), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CYP2C19(2), CYP2C9(5), DHRS1(2), DHRS2(2), DHRSX(1), ECHS1(1), EHHADH(3), ESCO1(1), PNPLA3(5), YOD1(1) 2253090 42 14 36 37 13 15 0 13 1 0 1.000 1.000 1.000 307 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS2(3), CARS2(5), DARS2(1), EPRS(2), FARS2(1), FARSA(2), FARSB(1), GARS(1), IARS(2), LARS(4), NARS2(1), PARS2(2), QARS(1), RARS(2), RARS2(5), SARS(1), VARS(3), VARS2(10), WARS2(1), YARS2(2) 3934887 50 14 41 79 9 26 1 10 4 0 1.000 1.000 1.000 308 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(2), CSNK1E(1), NPAS2(4), PER1(4), PER2(4), PER3(20) 1266817 35 14 22 27 5 13 0 16 1 0 0.999 1.000 1.000 309 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 BCL2(1), CASP9(4), FAS(5), IL1A(2), MAPKAPK2(1), TNF(3) 815402 16 14 14 26 3 7 1 2 3 0 1.000 1.000 1.000 310 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(4), ELK1(1), GRB2(1), IL2RA(1), IL2RB(2), JAK1(2), JAK3(2), MAP2K1(2), MAPK8(1), RAF1(4), SOS1(1) 1768450 21 14 20 40 4 9 2 2 4 0 1.000 1.000 1.000 311 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(4), CAPN2(4), EP300(5), HDAC2(2), NFATC1(6), NFATC2(2), PPP3CA(1), PPP3CC(1) 1783310 25 14 20 26 6 5 0 12 2 0 1.000 1.000 1.000 312 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(1), GNA13(2), GNGT1(1), MYLK(8), PLCB1(8), PPP1R12B(1) 1504290 23 14 19 19 3 4 2 5 9 0 0.993 1.000 1.000 313 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ARHGEF1(1), F2(1), F2R(1), F2RL3(1), GNA13(2), GNGT1(1), PIK3CA(2), PLCB1(8), PPP1R12B(1), PTK2B(4) 1892787 22 14 18 35 2 5 0 4 11 0 1.000 1.000 1.000 314 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(7), EP300(5), PELP1(6) 1122315 18 14 14 20 1 5 0 8 4 0 1.000 1.000 1.000 315 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), ALDOC(1), FBP2(2), G6PD(1), H6PD(3), PFKM(1), PGD(1), PGM1(4), PGM3(1), PRPS1L1(2), TKT(1) 1479934 18 14 15 49 6 9 0 3 0 0 1.000 1.000 1.000 316 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), DDC(3), EPX(3), GOT2(4), LPO(2), TAT(2), TPO(10) 1626548 37 14 32 39 14 11 2 9 1 0 1.000 1.000 1.000 317 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(4), CREBBP(7), DVL1(1), EP300(5), FZD1(1), PITX2(1), TRRAP(2) 2430669 21 14 20 26 5 6 1 6 3 0 1.000 1.000 1.000 318 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(7), EP300(5), LPL(1), NCOA1(2), NCOA2(1), PPARG(3) 1337157 19 14 17 12 1 7 0 7 4 0 0.984 1.000 1.000 319 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(8), CDC25C(4), MYT1(1), RB1(1), TP53(6) 1297749 20 14 17 19 5 9 0 3 3 0 0.996 1.000 1.000 320 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(3), CSF1(2), FCGR3A(15), IL6R(2), SELL(3), TGFB2(1), TNF(3), TNFRSF1B(3), TNFRSF8(6) 1024926 40 14 27 28 6 14 3 13 4 0 0.981 1.000 1.000 321 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(1), GLI2(6), GLI3(3), PRKACG(2), SHH(1), SMO(2) 1223834 18 14 15 29 6 3 1 6 2 0 1.000 1.000 1.000 322 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2R(1), F2RL3(1), GNGT1(1), ITGA1(3), MAP2K1(2), PLA2G4A(1), PLCB1(8), PTGS1(3), PTK2(2), RAF1(4), TBXAS1(5) 1779098 32 14 29 45 7 9 1 9 6 0 1.000 1.000 1.000 323 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(4), EGFR(4), GRB2(1), MAP2K1(2), PTPRB(8), RAF1(4), RASA1(2), SOS1(1), SPRY2(3), SPRY3(1) 1828397 31 14 24 33 3 18 4 5 1 0 1.000 1.000 1.000 324 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(8), APOA1(1), APOA4(4), APOC2(1), CETP(5), DGAT1(1), HMGCR(1), LCAT(1), LDLR(3), LIPC(3), LPL(1), LRP1(6), SOAT1(1) 1991949 36 14 28 46 9 16 2 8 1 0 1.000 1.000 1.000 325 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(4), CDH1(1), CREBBP(7), EP300(5), MAP2K1(2), TGFB2(1) 1878924 20 14 19 15 4 6 1 6 3 0 0.993 1.000 1.000 326 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(3), ACTN2(1), ITGA1(3), ITGB3(3), PTK2(2), RAC1(1), SPTAN1(1), TLN1(6) 2124621 20 14 15 31 5 4 2 6 3 0 1.000 1.000 1.000 327 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CASP9(4), CHUK(1), GH1(2), GHR(2), NFKB1(3), NFKBIA(3), PDPK1(1), PIK3CA(2), PPP2CA(1) 1081965 19 13 16 20 1 8 1 3 6 0 0.999 1.000 1.000 328 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(5), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH4A1(2), ALDH9A1(3), AOC2(2), AOC3(4), CKM(1), CPS1(5), DAO(2), GAMT(1), GOT2(4), NOS1(3), OTC(4), P4HA3(2), RARS(2) 3328985 51 13 40 68 16 16 0 17 2 0 1.000 1.000 1.000 329 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(3), ACAA2(3), ADH4(4), ADH7(2), ADHFE1(1), AKR1C4(4), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), BAAT(4), CEL(4), CYP27A1(1), HADHB(1), SOAT2(3) 1704298 44 13 34 47 8 19 1 11 5 0 1.000 1.000 1.000 330 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), ALDOC(1), FBP2(2), GOT2(4), GPT(1), MDH2(5), ME2(2), ME3(2), TKT(1) 1330472 19 13 16 29 4 7 1 7 0 0 1.000 1.000 1.000 331 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(7), EP300(5), NCOA3(3), PRKACG(2) 1523791 17 13 15 30 1 5 0 7 4 0 1.000 1.000 1.000 332 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND1(1), CCND2(2), CCND3(3), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), E2F1(2), RB1(1) 1174635 17 13 16 21 4 4 1 4 4 0 1.000 1.000 1.000 333 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 CS(5), IDH1(1), IDH3A(1), IDH3B(1), MDH2(5), PC(1), PCK1(3), SDHA(6), SUCLG2(1) 1500331 24 13 17 40 5 9 1 5 4 0 1.000 1.000 1.000 334 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ASAH1(4), GNGT1(1), ITGB3(3), PIK3CA(2), PLCB1(8), PTK2(2), RAC1(1), SMPD2(7), SPHK1(1) 1985882 29 13 20 46 5 7 2 8 7 0 1.000 1.000 1.000 335 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(4), MAP2K1(2), MAP3K1(7), NCOR2(9), THRA(1), THRB(2) 1301855 29 13 25 26 8 14 1 4 2 0 0.999 1.000 1.000 336 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(1), CSF2(1), HLA-DRA(2), HLA-DRB1(46), IL3(3) 208541 54 13 38 20 6 23 1 22 2 0 0.447 1.000 1.000 337 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(1), ALDOC(1), FBP2(2), FPGT(1), GMPPB(2), HK1(1), HK2(4), HK3(1), KHK(3), PFKM(1), PMM2(1), SORD(5) 1774868 23 13 17 48 7 6 0 9 1 0 1.000 1.000 1.000 338 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), FBP2(2), GAA(1), GALK2(1), GALT(2), GANAB(3), GLB1(1), HK1(1), HK2(4), HK3(1), LALBA(1), LCT(3), MGAM(12), PFKM(1), PGM1(4), PGM3(1) 2384083 39 13 33 69 6 17 1 9 6 0 1.000 1.000 1.000 339 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), JUNB(1), MAP2K3(4), NFATC1(6), NFATC2(2), PRKACG(2) 921502 17 13 14 25 5 3 1 7 1 0 1.000 1.000 1.000 340 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ELK1(1), GNAS(1), GNGT1(1), MAP2K1(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKACG(2), RAF1(4) 2587317 26 13 22 49 6 8 3 8 1 0 1.000 1.000 1.000 341 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 AGMAT(5), ALDH18A1(2), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), ASS1(1), CPS1(5), OTC(4), SRM(1) 2171687 38 13 29 39 9 14 0 13 2 0 1.000 1.000 1.000 342 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(4), ACP2(3), ACP5(1), ACP6(1), ACPT(8), ALPL(2), ALPP(13), ALPPL2(5), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), DHRS1(2), DHRS2(2), DHRSX(1), PON1(6), PON2(3) 1357289 62 13 42 44 12 17 1 23 9 0 0.999 1.000 1.000 343 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA1(2), FUCA2(8), GLB1(1), HEXB(5), LCT(3), MAN2B1(10), MAN2B2(10), MANBA(7), NEU2(3), NEU4(4) 1540625 55 13 30 36 17 25 3 9 1 0 0.977 1.000 1.000 344 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(1), C1GALT1C1(1), GALNT1(1), GALNT10(1), GALNT12(1), GALNT2(2), GALNT4(5), GALNT5(1), GALNT6(1), GALNT8(8), GALNT9(1), GALNTL5(5), GCNT1(4), GCNT4(2), ST6GALNAC1(3), WBSCR17(1) 2371249 39 13 29 43 6 20 1 12 0 0 1.000 1.000 1.000 345 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(5), PGAP1(2), PIGB(4), PIGC(3), PIGF(1), PIGG(7), PIGK(1), PIGL(1), PIGM(2), PIGN(3), PIGP(2), PIGQ(4), PIGS(1), PIGW(2), PIGZ(3) 1820298 41 13 32 61 4 22 2 12 1 0 1.000 1.000 1.000 346 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B3GNT3(1), B3GNT4(2), B3GNT5(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT2(1), FUT3(6), FUT4(1), FUT5(6), FUT6(7), ST3GAL6(1) 1175531 33 13 24 22 13 8 1 10 1 0 0.976 1.000 1.000 347 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(2), ACACB(12), ACADM(1), ACAT1(2), ACAT2(1), ACSS1(2), ACSS2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), ECHS1(1), EHHADH(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(7), MCEE(5), MUT(5), PCCA(1), PCCB(1), SUCLG2(1) 2888515 64 13 50 62 24 24 1 12 3 0 1.000 1.000 1.000 348 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(4), BST1(4), ENPP1(3), ENPP3(3), NADK(3), NADSYN1(1), NMNAT1(1), NMNAT2(1), NNT(2), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), NUDT12(2), QPRT(1) 1583122 32 13 24 30 7 15 2 3 5 0 1.000 1.000 1.000 349 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLG(2), POLG2(1), POLH(2), POLL(1), POLM(1), POLQ(15), PRIM1(1), REV1(8), REV3L(4), RFC5(1) 3042921 47 13 37 44 7 21 2 15 2 0 1.000 1.000 1.000 350 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(4), ELK1(1), GRB2(1), IRS1(2), MAP2K1(2), MAPK8(1), PIK3CA(2), RAF1(4), RASA1(2), SOS1(1) 1814064 20 13 19 22 2 11 2 1 4 0 1.000 1.000 1.000 351 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(1), HLA-DRA(2), HLA-DRB1(46), IL5RA(2), IL6(2) 380519 54 13 40 27 7 22 1 22 2 0 0.860 1.000 1.000 352 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(4), ELK1(1), GRB2(1), INSR(2), IRS1(2), MAP2K1(2), MAPK8(1), PIK3CA(2), RAF1(4), RASA1(2), SLC2A4(1), SOS1(1) 1871350 23 13 22 34 3 13 2 1 4 0 1.000 1.000 1.000 353 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(8), AASDHPPT(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DOT1L(2), ECHS1(1), EHHADH(3), EHMT1(1), EHMT2(2), PLOD1(2), PLOD2(2), SHMT1(3), SHMT2(1) 2719521 46 13 39 58 11 18 0 14 3 0 1.000 1.000 1.000 354 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(4), ENPP1(3), ENPP3(3), NADSYN1(1), NMNAT1(1), NMNAT2(1), NNT(2), NT5C(1), NT5E(2), NT5M(1), QPRT(1) 1071560 20 13 15 11 3 12 1 3 1 0 0.786 1.000 1.000 355 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(1), UCHL1(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2) 1249774 33 13 20 33 3 8 1 21 0 0 1.000 1.000 1.000 356 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(2), PLCB1(8), PLCG1(3), VAV1(3) 939047 16 13 13 16 1 2 2 4 7 0 0.999 1.000 1.000 357 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(1), CP(1), CPOX(1), EPRS(2), GUSB(1), HMOX1(3), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2), UROS(1) 1959904 43 13 29 44 6 12 1 24 0 0 1.000 1.000 1.000 358 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(2), ACADL(3), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(1), EHHADH(3), LDHA(1), MCEE(5), MUT(5), PCCA(1), PCCB(1), SUCLG2(1) 2418125 43 13 36 41 12 17 0 12 2 0 1.000 1.000 1.000 359 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(7), DFFA(1), GZMB(5), HMGB2(1), PRF1(2) 788678 16 13 14 12 4 2 2 5 3 0 0.982 1.000 1.000 360 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(3), DUSP4(2), EEF2K(3), GRB2(1), MAP2K1(2), MKNK1(1), MKNK2(3), MOS(2), NFKB1(3), RPS6KA1(2), RPS6KA2(1), SOS1(1), SOS2(1), TRAF3(4) 2214013 30 13 27 50 6 11 2 6 5 0 1.000 1.000 1.000 361 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(2), JAK3(2), STAT3(8), TYK2(3) 894433 17 13 17 19 4 3 1 8 1 0 1.000 1.000 1.000 362 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(3), LPO(2), TPO(10), TYR(9) 716695 24 13 17 15 9 5 2 8 0 0 0.960 1.000 1.000 363 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD3G(2), HLA-DRA(2), HLA-DRB1(46), PTPRC(1), ZAP70(1) 665273 53 13 39 28 6 21 1 22 3 0 0.932 1.000 1.000 364 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1), SLC23A1(1), SLC2A3(1) 1889149 34 13 26 50 8 10 1 10 5 0 1.000 1.000 1.000 365 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C5(6), C6(3), C7(7), C8A(9), C9(2) 926345 32 12 25 26 6 11 0 14 1 0 0.999 1.000 1.000 366 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BCL2(1), CASP8(3), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFKB1(3), RAF1(4) 1497609 22 12 20 29 4 9 3 2 4 0 1.000 1.000 1.000 367 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 FHL5(5), FSHR(5), GNAS(1), XPO1(3) 704071 14 12 10 11 5 4 2 3 0 0 0.980 1.000 1.000 368 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(4), CD2(1), CD33(10), CD5(3), CSF2(1), IFNA1(2), IL12B(2), IL3(3), ITGAX(6), TLR2(2), TLR4(2), TLR7(1) 1349278 37 12 27 16 8 16 3 7 3 0 0.579 1.000 1.000 369 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), DDX20(9), E2F1(2), ETS1(1), ETS2(2), HDAC2(2), NCOR2(9), RBL2(3) 2019780 30 12 22 43 7 12 2 7 2 0 1.000 1.000 1.000 370 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 CS(5), GRHPR(4), HAO1(1), HYI(1), MDH2(5), MTHFD1(4) 922493 20 12 14 22 3 6 1 7 3 0 1.000 1.000 1.000 371 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(7), GABBR1(1), GPRC5C(2), GRM1(2), GRM2(1), GRM4(1), GRM5(1), GRM7(1), GRM8(6) 1515042 22 12 17 36 4 5 2 11 0 0 1.000 1.000 1.000 372 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(2), MAP2K3(4), MAP3K1(7), NFKB1(3), PIK3CA(2), RB1(1), SP1(1) 1441506 20 12 18 28 4 7 2 2 5 0 1.000 1.000 1.000 373 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT2(1), G6PC2(6), GAA(1), GALK2(1), GALT(2), GANC(5), GLB1(1), HK1(1), HK2(4), HK3(1), HSD3B7(2), LALBA(1), LCT(3), MGAM(12), PFKM(1), PGM1(4), PGM3(1), RDH12(3) 2828641 50 12 38 78 9 18 3 14 6 0 1.000 1.000 1.000 374 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DDC(3), FTCD(1), HDC(4), HEMK1(1), HNMT(1), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1) 2933698 51 12 42 56 16 19 1 10 5 0 1.000 1.000 1.000 375 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT7(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), CHST2(1), CHST4(2), CHST6(1), FUT8(4), ST3GAL4(3) 890903 18 12 14 21 5 3 0 6 4 0 1.000 1.000 1.000 376 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(1), EXTL1(2), EXTL3(1), HS3ST1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(3), HS6ST2(1), HS6ST3(2), NDST1(1), NDST3(1) 1549052 16 12 15 44 2 4 1 7 2 0 1.000 1.000 1.000 377 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(4), ARSD(19), ARSE(1), ASAH1(4), CERK(2), DEGS1(1), DEGS2(4), ENPP7(4), GAL3ST1(4), GALC(3), GBA(2), GLB1(1), LCT(3), NEU2(3), NEU4(4), PPAP2B(1), SGPP1(1), SMPD2(7), SMPD4(2), SPHK1(1), SPHK2(1), UGT8(1) 2650200 73 12 49 72 12 28 3 25 5 0 1.000 1.000 1.000 378 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 AFMID(1), CS(5), GRHPR(4), HAO1(1), HYI(1), MDH2(5), MTHFD1(4) 968063 21 12 15 24 4 6 1 7 3 0 1.000 1.000 1.000 379 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACAT2(1), ACOT11(5), ACYP1(1), DHRS1(2), DHRS2(2), DHRSX(1), ECHS1(1), EHHADH(3), ESCO1(1), PNPLA3(5), YOD1(1) 1885055 25 12 21 27 5 10 0 10 0 0 1.000 1.000 1.000 380 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 14 BPNT1(1), CHST11(1), CHST12(4), CHST13(2), PAPSS1(5), PAPSS2(1), SULT1A1(3), SULT1A2(3), SULT2B1(3), SUOX(1) 850793 24 12 20 17 7 5 0 10 2 0 0.993 1.000 1.000 381 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(1), GTF2A1L(2), GTF2E1(1), GTF2F1(3), GTF2I(2), GTF2IRD1(1), STON1(3), TAF1(3), TAF1L(2), TAF2(2), TAF4(1), TAF4B(2), TAF5L(2), TAF6(1), TAF6L(1), TAF7L(5), TBPL2(4) 2721143 36 12 33 51 4 10 2 15 5 0 1.000 1.000 1.000 382 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(4), EIF2S2(1), EIF2S3(2), INPPL1(1), PDPK1(1), PIK3CA(2), PPP2CA(1), PTEN(2) 1483847 14 12 13 24 2 5 0 5 2 0 1.000 1.000 1.000 383 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CD3G(2), ETV5(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), JAK2(2), MAPK8(1), TYK2(3) 1381689 23 12 19 25 5 5 2 8 3 0 1.000 1.000 1.000 384 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 GRB2(1), IL4R(15), IRS1(2), JAK1(2), JAK3(2), STAT6(4) 1084453 26 12 19 26 5 9 6 4 2 0 1.000 1.000 1.000 385 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN2(4), EGF(4), EGFR(4), ITGA1(3), MYLK(8), PRKACG(2), PTK2(2), TLN1(6) 2464145 33 12 24 50 7 9 2 12 3 0 1.000 1.000 1.000 386 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(1), GALNT2(2), GALNT4(5), GALNT6(1), GALNT8(8), GALNT9(1), GCNT1(4), ST3GAL4(3), WBSCR17(1) 1076400 27 12 19 36 2 12 1 9 3 0 1.000 1.000 1.000 387 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CCND1(1), CDKN1A(4), CDKN1B(1), E2F1(2), NFKB1(3), NFKBIA(3), PIK3CA(2), RAC1(1), RAF1(4), RB1(1) 1489831 22 12 20 25 4 7 0 5 6 0 1.000 1.000 1.000 388 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(4), ACP2(3), ACP5(1), ACPT(8), ENPP1(3), ENPP3(3), FLAD1(1), TYR(9) 720331 32 12 17 13 10 8 2 10 2 0 0.646 1.000 1.000 389 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(1), BPNT1(1), GRB2(1), ILK(1), PIK3CA(2), PIK3CD(1), PTEN(2), PTK2B(4), RBL2(3), SOS1(1) 1478442 17 12 14 37 3 4 0 5 5 0 1.000 1.000 1.000 390 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCND1(1), CDKN1B(1), CDKN2A(1), E2F1(2), E2F2(3), PRB1(9) 659154 18 12 12 10 3 8 1 3 3 0 0.810 1.000 1.000 391 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(2), CTH(2), GGT1(6), MAT2B(1), PAPSS1(5), PAPSS2(1), SCLY(3) 916094 20 12 13 15 5 5 0 8 2 0 0.976 1.000 1.000 392 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 C9orf47(1), CNR2(4), DNMT1(2), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGFR(1), PTGIR(2) 848418 16 12 14 36 2 9 1 4 0 0 1.000 1.000 1.000 393 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(4), BRAF(3), RAF1(4), SNX13(1), TERF2IP(1) 848206 17 12 13 11 0 11 1 4 1 0 0.915 1.000 1.000 394 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 9 AKAP9(8), MAP2(2), PPP1CA(1), PPP2CA(1), PRKACG(2) 1224276 14 11 10 21 0 7 0 7 0 0 1.000 1.000 1.000 395 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD80(2), HLA-DRA(2), HLA-DRB1(46) 284773 50 11 36 27 5 21 1 21 2 0 0.937 1.000 1.000 396 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRA(2), HLA-DRB1(46) 169872 48 11 34 22 5 19 1 21 2 0 0.766 1.000 1.000 397 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(4), DBH(7), DDC(3), GAD1(2), GAD2(1), HDC(4), PAH(1), TH(3) 1060398 26 11 18 33 14 5 1 6 0 0 1.000 1.000 1.000 398 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2) 662195 16 11 13 25 6 5 3 1 1 0 1.000 1.000 1.000 399 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 BIRC2(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), GZMB(5), LMNA(3), PRF1(2) 1424390 28 11 22 36 7 5 3 9 4 0 1.000 1.000 1.000 400 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CCL2(1), CCL4(3), CXCR4(4), MAPK8(1), PLCG1(3), PTK2B(4) 987940 16 11 11 25 1 3 3 6 3 0 1.000 1.000 1.000 401 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5R1(1), DRD2(1), GRM1(2), PLCB1(8), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKACG(2) 1180726 17 11 14 29 0 2 0 7 8 0 1.000 1.000 1.000 402 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(1), FLT3(1), IL11(1), IL1A(2), IL3(3), IL6(2), IL9(1), KITLG(1), TGFB2(1) 631490 13 11 11 12 5 5 0 3 0 0 0.970 1.000 1.000 403 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F2R(1), F5(18), F7(3), FGA(2), FGB(1), FGG(1), PROC(2), PROS1(1), SERPINC1(1) 1207552 32 11 23 39 8 20 0 4 0 0 1.000 1.000 1.000 404 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(2), F13A1(8), F2(1), F2R(1), FGA(2), FGB(1), FGG(1), PLAT(1), PLG(4), SERPINB2(4), SERPINE1(1) 974522 26 11 18 31 4 13 0 9 0 0 1.000 1.000 1.000 405 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(4), ARSB(5), ARSD(19), ARSE(1), ASAH1(4), GAL3ST1(4), GALC(3), GBA(2), GLB1(1), LCT(3), NEU2(3), NEU4(4), PPAP2B(1), SMPD2(7) 1799739 61 11 37 52 10 23 2 22 4 0 1.000 1.000 1.000 406 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(2), ACACB(12), FASN(3), MCAT(1) 1217851 18 11 15 23 11 4 1 2 0 0 1.000 1.000 1.000 407 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2) 662195 16 11 13 25 6 5 3 1 1 0 1.000 1.000 1.000 408 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT2(3), IARS(2), LARS(4), PDHA2(2), VARS(3), VARS2(10) 1352774 24 11 17 40 5 14 1 3 1 0 1.000 1.000 1.000 409 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(2), DHRS2(2), DHRSX(1), HSD3B7(2), PON1(6), PON2(3), RDH12(3) 649246 19 11 14 20 5 5 0 9 0 0 0.999 1.000 1.000 410 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(5), GALNS(2), GLB1(1), GUSB(1), HEXB(5), HGSNAT(1), HPSE(2), HPSE2(6), IDS(1), IDUA(5), LCT(3), NAGLU(3) 1543835 35 11 24 43 13 11 2 9 0 0 1.000 1.000 1.000 411 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(1), CHPT1(2), ENPP2(3), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLD1(4), PLD2(13), PPAP2B(1) 1736404 32 11 22 36 8 8 4 7 5 0 1.000 1.000 1.000 412 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(6), AMT(1), ATIC(1), FTCD(1), GART(3), MTHFD1(4), MTHFR(4), MTR(4), SHMT1(3), SHMT2(1) 1405984 28 11 20 22 5 17 1 5 0 0 0.989 1.000 1.000 413 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(3), LPO(2), MTHFR(4), SHMT1(3), SHMT2(1), TPO(10) 846904 23 11 18 24 6 8 2 7 0 0 1.000 1.000 1.000 414 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), AOC2(2), AOC3(4), CES1(12), DDHD1(1), ESCO1(1), LIPA(3), PLA1A(2), PNPLA3(5) 1854740 32 11 24 15 6 13 0 10 3 0 0.830 1.000 1.000 415 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(7), ACOX3(1), ELOVL6(1), FASN(3), HSD17B12(2), PECR(4), SCD(2) 1132589 23 11 17 18 7 6 0 10 0 0 0.985 1.000 1.000 416 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG7(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), PIK3C3(1), PIK3R4(1), PRKAA1(1), ULK1(3), ULK2(1), ULK3(3) 1574589 32 11 29 20 5 12 1 10 4 0 0.945 1.000 1.000 417 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(3), LPO(2), SHMT1(3), SHMT2(1), TPO(10) 872150 19 11 15 19 6 6 2 5 0 0 0.999 1.000 1.000 418 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA1(2), FUCA2(8), GLB1(1), HEXB(5), LCT(3), MANBA(7), NEU2(3), NEU4(4) 1250472 35 11 18 33 10 16 3 5 1 0 1.000 1.000 1.000 419 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), NOS1(3), PPP3CA(1), PPP3CC(1), PRKACG(2) 1912188 16 11 13 55 5 5 0 5 1 0 1.000 1.000 1.000 420 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(6), AMT(1), ATIC(1), GART(3), MTHFD1(4), MTHFR(4), MTR(4), SHMT1(3), SHMT2(1) 1303963 27 11 19 19 4 17 1 5 0 0 0.970 1.000 1.000 421 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(3), NFKBIA(3), PLCB1(8) 608492 14 11 11 14 1 1 0 3 9 0 0.999 1.000 1.000 422 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 GTF2A1(1), GTF2E1(1), GTF2F1(3), NCOA1(2), NCOA2(1), NCOA3(3), NCOR2(9), TBP(2) 1867153 22 11 21 34 6 8 1 3 4 0 1.000 1.000 1.000 423 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 GTF2E1(1), ILK(1), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3E(1), TAF6(1), TBP(2) 2586925 13 11 13 54 4 3 0 4 2 0 1.000 1.000 1.000 424 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 BIRC2(1), CASP10(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), GZMB(5), PRF1(2), SCAP(3), SREBF1(1), SREBF2(5) 1391676 30 11 22 21 9 6 3 11 1 0 0.987 1.000 1.000 425 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(1), ITPKA(1), PDE1B(1), PLCB1(8), TRH(2) 818032 13 11 10 21 0 3 0 4 6 0 1.000 1.000 1.000 426 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), TYK2(3) 764587 23 11 16 26 3 6 6 8 0 0 1.000 1.000 1.000 427 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), TYK2(3) 764587 23 11 16 26 3 6 6 8 0 0 1.000 1.000 1.000 428 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC1B(3), NCK1(2), NCKAP1(2), NTRK1(3), RAC1(1), WASF1(1), WASF3(3), WASL(1) 1125112 16 10 14 19 6 4 1 5 0 0 0.999 1.000 1.000 429 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ADSS(1), AGXT(1), AGXT2(4), CAD(1), DDO(1), GAD1(2), GAD2(1), GOT2(4), GPT(1), PC(1) 1913999 17 10 14 35 5 2 1 9 0 0 1.000 1.000 1.000 430 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(1), GFPT1(1), HEXB(5), HK1(1), HK2(4), HK3(1), PGM3(1), UAP1(1) 1258083 15 10 11 31 2 8 0 4 1 0 1.000 1.000 1.000 431 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3) 1106699 14 10 12 15 3 9 1 1 0 0 0.991 1.000 1.000 432 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 BCL2(1), CSF2RB(3), IL3(3), IL3RA(4), KITLG(1), PIK3CA(2), PRKACG(2) 1610040 16 10 10 40 2 4 0 10 0 0 1.000 1.000 1.000 433 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CDKN1A(4), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), SP1(1), SP3(2) 1502460 22 10 18 24 4 7 2 8 1 0 1.000 1.000 1.000 434 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), EGF(4), EGFR(4), GRB2(1), MET(2), SH3GLB2(2) 1409572 14 10 12 39 1 9 0 2 2 0 1.000 1.000 1.000 435 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(3), ACTN2(1), BCAR1(2), CSK(3), CTNNA2(3), PTK2(2) 1433513 14 10 12 24 4 2 1 6 1 0 1.000 1.000 1.000 436 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 CAMK2G(1), GNAS(1), GRB2(1), PIK3CA(2), PRKACG(2), RAC1(1), RPS6KA1(2), RPS6KA5(1), SOS1(1) 2173768 12 10 10 51 2 4 0 5 1 0 1.000 1.000 1.000 437 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(6), SHMT1(3), SHMT2(1) 319924 10 10 6 5 3 3 0 4 0 0 0.789 1.000 1.000 438 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 GRB2(1), MAPK7(1), MEF2B(3), MEF2C(1), NTRK1(3), PIK3CA(2), PLCG1(3), RPS6KA1(2) 1459328 16 10 13 33 2 4 2 6 2 0 1.000 1.000 1.000 439 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3) 1106699 14 10 12 15 3 9 1 1 0 0 0.991 1.000 1.000 440 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 8 GABRA1(2), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(3) 476131 13 10 10 8 1 7 0 5 0 0 0.923 1.000 1.000 441 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(2), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(3), GPHN(2), UBQLN1(1) 932848 16 10 13 15 1 7 0 8 0 0 0.999 1.000 1.000 442 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DDC(3), HDC(4), HNMT(1) 1797143 39 10 32 37 13 12 1 9 4 0 1.000 1.000 1.000 443 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(5), CTH(2), GOT2(4), LDHA(1), LDHAL6A(2), LDHAL6B(7), SULT1C2(2), SULT1C4(3), SULT4A1(1) 922822 27 10 19 23 4 8 0 12 3 0 1.000 1.000 1.000 444 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(4), GAD1(2), GAD2(1), GGT1(6) 428172 13 10 9 9 4 2 0 7 0 0 0.943 1.000 1.000 445 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ADH4(4), ADH7(2), ADHFE1(1), DHRS1(2), DHRS2(2), DHRSX(1), ESCO1(1), PNPLA3(5) 1804083 19 10 14 27 1 6 1 9 2 0 1.000 1.000 1.000 446 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS1(2), DHRS2(2), DHRSX(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1) 1089110 15 10 12 18 3 9 0 2 1 0 0.998 1.000 1.000 447 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(3), APOBEC1(3), APOBEC2(2), APOBEC3B(3), APOBEC3C(1), APOBEC3F(3), APOBEC3G(1), APOBEC4(8) 527269 24 10 18 29 2 18 0 3 1 0 1.000 1.000 1.000 448 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), CA13(1), CA3(2), CA5A(1), CA6(5), CA9(5), CPS1(5), CTH(2), GLS(1), GLS2(2) 1540055 25 10 16 29 3 7 3 9 3 0 1.000 1.000 1.000 449 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(3), GBA(2), LPO(2), TPO(10) 618695 17 10 14 15 5 3 3 5 1 0 0.996 1.000 1.000 450 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT2(4), TAT(2), TYR(9) 339632 18 10 13 11 8 4 0 6 0 0 0.928 1.000 1.000 451 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(4), IFNAR2(3), JAK1(2), STAT1(1), STAT2(3), TYK2(3) 795943 18 10 15 19 4 4 1 8 1 0 0.999 1.000 1.000 452 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(6), ITGA4(5), ITGAL(1), SELE(3), SELL(3) 892169 21 10 16 30 4 10 0 6 0 1 1.000 1.000 1.000 453 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(3), ACADM(1), ACADS(1), ACADVL(1), ACSL3(2), CPT2(5), EHHADH(3), PECR(4) 1226141 20 10 15 17 2 12 0 4 2 0 0.993 1.000 1.000 454 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(6), ITGA4(5), ITGAL(1), ITGAM(6), SELE(3), SELL(3), SELP(6) 1185802 33 10 25 39 7 17 0 8 0 1 1.000 1.000 1.000 455 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(6), ABCB11(2), ABCC1(3), ABCC3(5), GSTP1(1) 1054274 17 10 15 36 5 8 1 1 2 0 1.000 1.000 1.000 456 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A2(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), MKNK1(1), PDPK1(1), PIK3CA(2), PPP2CA(1), PTEN(2), TSC1(4) 2061261 17 10 17 34 3 4 1 6 3 0 1.000 1.000 1.000 457 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), DPAGT1(2), FUT8(4), MAN1B1(1), MGAT1(6), MGAT4A(2), MGAT5(1), RPN2(1), ST6GAL1(3) 1490312 25 10 21 20 6 8 3 8 0 0 0.993 1.000 1.000 458 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), CA3(2), CA5A(1), CA6(5), CA9(5), CPS1(5), CTH(2), GLS(1), GLS2(2) 1378211 24 10 15 28 3 6 3 9 3 0 1.000 1.000 1.000 459 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(1), CD3D(1), CD3G(2), IL12B(2), IL12RB1(8), IL12RB2(2), JAK2(2), TYK2(3) 1100637 21 10 17 24 5 4 1 9 2 0 1.000 1.000 1.000 460 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), FDXR(2), SHMT1(3) 1175640 16 10 13 16 5 9 1 1 0 0 0.989 1.000 1.000 461 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 29 ANXA2(1), ANXA4(2), EDN1(3), EDNRA(1), HPGD(1), PLA2G4A(1), PTGFR(1), PTGIR(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5) 1618270 22 10 18 34 6 3 0 13 0 0 1.000 1.000 1.000 462 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 BTK(2), EEA1(4), LYN(2), PDPK1(1), PFKM(1), PLCG1(3), RAC1(1), VAV2(3) 1820945 17 10 14 42 4 5 2 4 2 0 1.000 1.000 1.000 463 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CASP9(4), CHUK(1), ELK1(1), MAP2K1(2), NFKB1(3), PIK3CA(2), RAC1(1), RAF1(4), RALBP1(1), RALGDS(1), RHOA(2) 1448425 22 10 19 27 5 12 2 1 2 0 1.000 1.000 1.000 464 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5R1(1), DAB1(2), LRP8(3), RELN(9), VLDLR(2) 1008604 17 10 16 11 2 3 1 8 3 0 0.961 1.000 1.000 465 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 BCL10(2), BCL2(1), CASP9(4), CES1(12) 861646 19 10 12 20 4 8 1 3 3 0 0.999 1.000 1.000 466 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(4), JAK1(2), PTPRU(4), STAT1(1), STAT2(3), TYK2(3) 918688 17 10 14 20 4 4 1 7 1 0 1.000 1.000 1.000 467 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3) 1106699 14 10 12 15 3 9 1 1 0 0 0.991 1.000 1.000 468 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(2), HMGCR(1), LSS(3), MVK(2), NQO1(4), NQO2(3), SQLE(1) 823173 17 9 14 29 3 8 3 1 2 0 1.000 1.000 1.000 469 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5R1(1), DPM2(1), EGR1(1), KLK2(1), MAP2K1(2), NGFR(2), RAF1(4) 621918 12 9 12 19 2 4 2 2 2 0 1.000 1.000 1.000 470 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(2), CASP1(1), CASP10(2), CASP8(3), CASP9(4), GZMB(5), PRF1(2) 925166 19 9 15 22 5 5 3 3 3 0 1.000 1.000 1.000 471 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(4), EGF(4), EGFR(4), HGS(1), TF(2), TFRC(2) 929705 17 9 14 30 3 9 0 5 0 0 1.000 1.000 1.000 472 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHB1(3), ITGA1(3), L1CAM(1), LYN(2), SELP(6) 1140399 15 9 13 25 4 6 2 3 0 0 1.000 1.000 1.000 473 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), KHK(3), LCT(3), PGM1(4), PYGL(4) 1013251 15 9 10 25 4 8 0 1 2 0 1.000 1.000 1.000 474 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(1), EDN1(3), EP300(5), LDHA(1) 1247726 11 9 8 17 1 5 0 5 0 0 1.000 1.000 1.000 475 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(2), FARSB(1), GOT2(4), PAH(1), TAT(2), YARS2(2) 632714 13 9 11 18 2 3 1 6 1 0 1.000 1.000 1.000 476 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(3), PCYT1B(1), PRMT2(1), PRMT6(2), PRMT8(1) 1023131 13 9 10 15 2 9 0 1 1 0 0.995 1.000 1.000 477 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 CHST11(1), CHST12(4), CHST13(2), CHSY1(3), DSE(8), UST(1), XYLT1(4), XYLT2(5) 1072776 28 9 20 24 6 10 0 12 0 0 0.997 1.000 1.000 478 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(6), HSD3B7(2), RDH12(3) 344273 11 9 7 11 4 4 0 0 3 0 0.987 1.000 1.000 479 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS2(2), DHRSX(1), ESCO1(1), PNPLA3(5) 1190333 11 9 9 14 1 4 0 6 0 0 0.999 1.000 1.000 480 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPS7(1), RPL10L(2), RPL13(1), RPL14(1), RPL3(1), RPL37(1), RPL3L(2), RPL6(1) 1559020 10 9 10 31 5 3 1 0 1 0 1.000 1.000 1.000 481 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR2(2), SNAP25(1), STX16(2), STX17(3), STX18(1), STX2(2), TSNARE1(9), VTI1A(1) 1245829 21 9 16 25 5 7 1 5 3 0 1.000 1.000 1.000 482 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD3D(1), CD3G(2), CD58(1), IL3(3), IL6(2), KITLG(1) 460709 11 9 9 17 1 5 0 3 2 0 1.000 1.000 1.000 483 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(4), ST3GAL4(3) 568409 12 9 9 17 4 0 0 5 3 0 1.000 1.000 1.000 484 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(2), LEPR(10), PRKAA1(1) 1041897 13 9 7 14 1 3 6 3 0 0 0.996 1.000 1.000 485 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(1), EHHADH(3) 896625 18 9 17 19 4 8 0 5 1 0 0.999 1.000 1.000 486 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 BCL2(1), BIRC2(1), CASP7(3), CASP8(3), CASP9(4), DFFA(1), ENDOG(2) 991943 15 9 12 19 2 5 1 6 1 0 1.000 1.000 1.000 487 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), BIN1(1), EPS15(3), PPP3CA(1), PPP3CC(1), SYNJ1(2), SYNJ2(3) 1686103 13 9 10 32 1 7 0 3 2 0 1.000 1.000 1.000 488 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA3(4), P2RY1(1), P2RY2(5), P2RY6(1) 424295 12 9 8 7 5 1 0 6 0 0 0.822 1.000 1.000 489 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO3(2), FARS2(1), GOT2(4), PAH(1), TAT(2) 595778 11 9 9 14 2 4 0 5 0 0 0.999 1.000 1.000 490 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMB1(3), PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), RPN2(1), UBE2A(4) 968825 13 9 10 14 2 3 0 3 5 0 0.999 1.000 1.000 491 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(4), BTRC(1), DVL1(1), FZD1(1), NOTCH1(2), PSEN1(1) 1638098 11 9 11 29 3 3 1 3 1 0 1.000 1.000 1.000 492 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(2), CDKN1B(1), GRB2(1), ILK(1), PDPK1(1), PIK3CA(2), PTEN(2), PTK2(2), SOS1(1) 1450523 13 9 13 36 3 3 0 4 3 0 1.000 1.000 1.000 493 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(1), CDKN1A(4), ELK1(1), GRB2(1), MAP2K1(2), NGFR(2), NTRK1(3), PIK3CA(2), PIK3CD(1), SOS1(1) 1236506 18 9 17 25 5 5 2 4 2 0 1.000 1.000 1.000 494 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(4), CKM(1), GPT(1), LDHA(1), NCL(4) 663110 11 9 10 18 3 4 0 1 3 0 1.000 1.000 1.000 495 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25C(4), CSK(3), GRB2(1), PTPRA(2) 678402 10 9 9 13 3 1 1 2 3 0 0.999 1.000 1.000 496 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B1(2), HSD17B4(4), HSD17B7(4), HSD3B1(2), HSD3B2(2) 589135 15 9 12 17 3 9 2 1 0 0 0.996 1.000 1.000 497 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD3G(2), ICAM1(6), ITGAL(1), PTPRC(1) 767381 12 9 9 20 1 4 0 6 1 0 1.000 1.000 1.000 498 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD3G(2), ICAM1(6), ITGAL(1), PTPRC(1) 809519 12 9 9 18 1 4 0 6 1 0 1.000 1.000 1.000 499 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 DPM2(1), GRB2(1), KLK2(1), NTRK1(3), PIK3CA(2), PLCG1(3), SOS1(1) 1141683 12 9 11 22 2 4 2 3 1 0 1.000 1.000 1.000 500 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3) 588587 14 8 13 16 4 5 0 4 1 0 0.999 1.000 1.000 501 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(4), AGTR1(2), AGTR2(3), KNG1(6) 741110 17 8 14 17 4 3 0 10 0 0 0.998 1.000 1.000 502 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNG(1), MUSK(5), PIK3CA(2), PTK2(2), PTK2B(4), RAPSN(1), TERT(1) 1234919 16 8 13 34 5 3 0 4 4 0 1.000 1.000 1.000 503 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP3(2), CLTB(1), COPA(1), GBF1(2), GPLD1(5), KDELR3(3) 1176426 14 8 9 17 5 4 0 4 1 0 0.999 1.000 1.000 504 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3) 588587 14 8 13 16 4 5 0 4 1 0 0.999 1.000 1.000 505 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1G(1), CAMK2G(1), CAMK4(1), CAMKK1(1), CAMKK2(5) 875442 9 8 7 26 2 2 0 4 1 0 1.000 1.000 1.000 506 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25C(4), MYT1(1) 1014844 13 8 10 14 3 7 0 3 0 0 0.995 1.000 1.000 507 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15) 1233070 24 8 20 24 4 10 2 7 1 0 0.999 1.000 1.000 508 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(3), DFFA(1), ENDOG(2), GZMB(5), HMGB2(1), TOP2A(3), TOP2B(2) 775933 17 8 13 17 1 3 2 10 1 0 1.000 1.000 1.000 509 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(4), EPOR(1), JAK2(2), NFKB1(3), NFKBIA(3) 967345 14 8 12 18 2 3 0 6 3 0 1.000 1.000 1.000 510 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(4), ERBB3(1), NRG1(4) 739620 13 8 10 14 2 6 0 5 0 0 0.998 1.000 1.000 511 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(4), NRG2(1), NRG3(2), PSEN1(1) 663032 9 8 8 15 2 1 0 4 2 0 1.000 1.000 1.000 512 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 GPD2(3), SDHA(6), SDHC(1), UQCRC1(1) 473181 11 8 9 18 6 1 0 3 1 0 1.000 1.000 1.000 513 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(5), GALNS(2), GLB1(1), GUSB(1), HEXB(5), IDS(1), IDUA(5), LCT(3), NAGLU(3) 1077485 26 8 17 38 12 9 2 3 0 0 1.000 1.000 1.000 514 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(2), GPR171(1), GPR18(1), GPR34(1), GPR39(3), GPR45(1), GPR68(1), GPR75(1) 715879 12 8 11 12 1 9 0 1 1 0 0.986 1.000 1.000 515 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3) 631532 14 8 13 28 3 5 0 5 1 0 1.000 1.000 1.000 516 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 BHMT(1), CBS(2), CTH(2), DNMT1(2), DNMT3B(1), MAT2B(1), MTAP(2), MTR(4), SRM(1), TAT(2) 1528170 18 8 14 23 4 8 0 4 2 0 1.000 1.000 1.000 517 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(1), HK2(4), HK3(1), IMPA2(1), PGM1(4), PGM3(1) 877141 12 8 10 29 2 7 0 2 1 0 1.000 1.000 1.000 518 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(7), ACOX3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1) 790092 15 8 13 12 5 3 1 6 0 0 0.980 1.000 1.000 519 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(3), GLB1(1), HEXB(5), LCT(3), SLC33A1(1), ST3GAL5(3), ST6GALNAC3(1) 1198130 17 8 11 23 1 12 1 3 0 0 1.000 1.000 1.000 520 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3) 978665 21 8 17 26 3 7 1 7 3 0 1.000 1.000 1.000 521 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACSS1(2), ACSS2(1), IDH1(1), MDH2(5) 964320 11 8 7 15 3 4 1 3 0 0 0.999 1.000 1.000 522 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), EHHADH(3), HSD17B4(4), NTAN1(4), SIRT1(2), SIRT5(1) 867807 15 8 12 18 0 8 1 5 1 0 1.000 1.000 1.000 523 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4) 1688473 11 8 10 41 2 4 0 5 0 0 1.000 1.000 1.000 524 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(5), OGDH(2), SDHA(6) 684984 13 8 9 24 5 0 0 5 3 0 1.000 1.000 1.000 525 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CCL2(1), CSF1(2), IL6(2), LDLR(3), LPL(1) 385027 11 8 7 15 1 4 2 3 1 0 1.000 1.000 1.000 526 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 CDC25C(4), GNAS(1), GNGT1(1), MYT1(1), PRKACG(2), RPS6KA1(2) 1534712 11 8 8 37 5 0 0 6 0 0 1.000 1.000 1.000 527 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(6), ITGAL(1), ITGAM(6), SELE(3), SELL(3) 785544 22 8 16 23 3 14 0 5 0 0 0.999 1.000 1.000 528 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CDK5R1(1), CSNK1A1(2), MAPT(16), PPP2CA(1) 721733 20 8 11 13 8 9 0 1 2 0 0.883 1.000 1.000 529 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR1(4), IFNAR2(3), MAPK8(1), NFKB1(3), TNFRSF11A(3), TRAF6(1) 800175 15 8 10 10 3 4 1 5 2 0 0.950 1.000 1.000 530 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(4), MMP2(1), MMP9(3), RECK(2), TIMP2(1), TIMP4(1) 567106 12 8 9 24 4 1 2 4 1 0 1.000 1.000 1.000 531 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDKN1A(4), NEK1(8) 565779 12 8 9 11 3 6 0 3 0 0 0.983 1.000 1.000 532 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(2), JAK2(2), JAK3(2), PIAS1(1), PTPRU(4), SOAT1(1) 1038087 13 8 12 21 4 4 1 4 0 0 1.000 1.000 1.000 533 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(1), HK2(4), HK3(1), PGM1(4), PGM3(1) 766618 11 8 9 22 2 6 0 2 1 0 1.000 1.000 1.000 534 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(4), UBE2D3(1), UBE2E3(1), UBE2J1(1) 771387 8 8 8 18 1 1 0 1 5 0 1.000 1.000 1.000 535 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(2), CKM(1), CPS1(5), GAMT(1), OTC(4) 1372499 13 8 8 20 3 5 0 4 1 0 1.000 1.000 1.000 536 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), PTGS1(3), PTGS2(1) 381456 7 7 6 8 1 1 0 5 0 0 0.998 1.000 1.000 537 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(15), PRKACG(2) 742959 17 7 13 15 6 4 0 7 0 0 0.995 1.000 1.000 538 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 EPRS(2), FARS2(1), GARS(1), IARS(2), LARS(4), QARS(1), RARS(2), SARS(1), WARS2(1) 2301515 15 7 10 48 1 10 0 4 0 0 1.000 1.000 1.000 539 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADRB2(3), CFTR(5), GNAS(1), PRKACG(2) 971932 11 7 7 30 1 5 0 3 2 0 1.000 1.000 1.000 540 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDFT1(2), HMGCR(1), LSS(3), MVK(2), NSDHL(1), SQLE(1) 977112 11 7 10 31 3 4 2 1 1 0 1.000 1.000 1.000 541 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), ACAA2(3), ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(3), HADHB(1) 617928 14 7 10 11 0 8 0 5 1 0 0.983 1.000 1.000 542 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NFKB1(3), TNF(3), XDH(6) 738471 12 7 9 11 1 7 0 1 3 0 0.989 1.000 1.000 543 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(3), FUT1(1), FUT2(1), GBGT1(4), HEXB(5), NAGA(1), ST3GAL4(3) 731897 18 7 10 23 1 10 0 2 5 0 1.000 1.000 1.000 544 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT5(1), B3GNT5(2), FUT1(1), FUT2(1), FUT3(6), ST3GAL4(3) 522310 14 7 9 14 2 3 0 6 3 0 0.996 1.000 1.000 545 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(3), B3GALNT1(3), B3GALT5(1), FUT1(1), FUT2(1), GBGT1(4), HEXB(5), NAGA(1) 775409 19 7 11 19 1 14 0 2 2 0 0.996 1.000 1.000 546 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 GRB2(1), IRS1(2), MAP2K1(2), PIK3CA(2), RAF1(4), SOS1(1) 1373965 12 7 12 25 2 6 1 1 2 0 1.000 1.000 1.000 547 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(1), CBS(2), CTH(2), DNMT1(2), DNMT3B(1), MAT2B(1), MTR(4) 1280246 13 7 10 20 1 7 0 3 2 0 1.000 1.000 1.000 548 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), GREB1(6), MTA1(4), TUBA8(3) 848385 14 7 10 14 10 2 0 2 0 0 0.983 1.000 1.000 549 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(7), GAD1(2), HDC(4), TH(3) 442339 16 7 9 16 11 0 1 4 0 0 0.993 1.000 1.000 550 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1G(1), CAMK2G(1), CAMK4(1), MEF2B(3), MEF2C(1), PPARA(1), PPP3CA(1), PPP3CC(1), SLC2A4(1) 1563287 11 7 10 42 3 3 0 3 2 0 1.000 1.000 1.000 551 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADRB2(3), GNAS(1), PLCE1(8), PRKACG(2) 1114755 14 7 12 32 2 6 1 5 0 0 1.000 1.000 1.000 552 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMB1(3), PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), PSMB8(1), PSMB9(2) 639812 11 7 7 14 4 2 0 4 1 0 0.999 1.000 1.000 553 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25C(4), SHH(1), XPO1(3) 639780 8 7 6 11 6 0 0 2 0 0 0.998 1.000 1.000 554 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(10) 586001 10 7 6 8 1 6 1 2 0 0 0.910 1.000 1.000 555 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 CASP8(3), TNF(3), TNFRSF1B(3) 611399 9 7 8 15 1 2 0 4 2 0 1.000 1.000 1.000 556 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), JAK1(2), JAK2(2), PTPRU(4), STAT1(1) 836344 10 7 9 25 2 4 0 4 0 0 1.000 1.000 1.000 557 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CSF1(2), CSF2(1), IL11(1), IL3(3), IL6(2), IL9(1) 460993 10 7 7 21 2 5 2 1 0 0 1.000 1.000 1.000 558 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), CD3G(2), IL2RA(1), TGFB2(1), TGFBR3(2) 785579 7 7 7 15 1 2 0 2 2 0 1.000 1.000 1.000 559 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFS1(1), NDUFS2(3), NDUFV2(4) 520163 8 7 5 8 1 1 0 6 0 0 0.994 1.000 1.000 560 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), PPARG(3), TNF(3) 416737 7 7 6 11 0 1 0 4 2 0 1.000 1.000 1.000 561 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS2(1), CPO(5), UROS(1) 621764 9 6 7 16 2 5 0 2 0 0 1.000 1.000 1.000 562 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACAT2(1), ACYP1(1), ECHS1(1), EHHADH(3) 570606 8 6 7 10 0 4 0 4 0 0 0.999 1.000 1.000 563 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1B(3), PIK3CA(2), RAC1(1), WASL(1) 981086 7 6 6 10 2 1 0 4 0 0 0.999 1.000 1.000 564 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5) 514100 11 6 9 24 2 3 0 5 1 0 1.000 1.000 1.000 565 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(4), CYP11B2(5), HSD3B1(2), HSD3B2(2) 502862 13 6 10 16 6 3 3 0 1 0 0.998 1.000 1.000 566 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(1), PTK2B(4), SOS1(1) 636551 6 6 4 17 0 1 0 1 4 0 1.000 1.000 1.000 567 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS2(1), CPOX(1), PPOX(2), UROS(1) 568954 7 6 7 10 3 1 0 3 0 0 1.000 1.000 1.000 568 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5) 514100 11 6 9 24 2 3 0 5 1 0 1.000 1.000 1.000 569 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(5), COQ5(2), COQ6(2), COQ7(2) 315346 11 6 5 6 4 6 1 0 0 0 0.733 1.000 1.000 570 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMB1(3), PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), PSMD13(1), PSMD2(1) 1168763 10 6 7 17 2 3 0 4 1 0 1.000 1.000 1.000 571 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1), SRP68(1), SRP72(2), SRPR(1) 542736 6 6 6 13 3 1 0 1 1 0 1.000 1.000 1.000 572 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), ANKRD1(1), IL1A(2), IL1R1(1), MYOG(1), NR4A3(1), WDR1(1) 810356 8 6 8 21 3 1 0 3 1 0 1.000 1.000 1.000 573 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 GH1(2), GHR(2), PIK3CA(2) 960523 6 6 6 19 0 2 0 2 2 0 1.000 1.000 1.000 574 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), CBS(2), CTH(2), MUT(5) 364148 10 6 7 6 6 1 0 3 0 0 0.834 1.000 1.000 575 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC1B(3), RAC1(1), WASF1(1), WASL(1) 602723 6 6 5 6 3 0 0 3 0 0 0.979 1.000 1.000 576 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(2), GOT2(4), LDHA(1) 493188 7 5 5 12 1 1 0 5 0 0 1.000 1.000 1.000 577 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL4(3), ST3GAL5(3), ST6GALNAC2(1) 409943 7 5 3 11 1 3 0 0 3 0 0.995 1.000 1.000 578 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(3), GNAS(1), GNGT1(1), NFKB1(3), NPPA(1), PIK3CA(2) 1339315 11 5 9 23 3 4 0 2 2 0 1.000 1.000 1.000 579 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(4), TAT(2) 191112 6 5 5 9 2 1 0 3 0 0 0.999 1.000 1.000 580 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), GGPS1(1), IDI2(2), SQLE(1) 320695 6 5 6 12 0 0 2 1 3 0 1.000 1.000 1.000 581 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(2), CYP2C9(5) 144812 7 5 5 4 5 1 0 1 0 0 0.924 1.000 1.000 582 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR2(2), JAK1(2), JAK2(2), STAT1(1) 592569 7 5 6 21 1 4 0 2 0 0 1.000 1.000 1.000 583 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(5), PLCG1(3), PTK2B(4) 490665 12 5 6 17 3 1 2 3 3 0 1.000 1.000 1.000 584 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), FURIN(2), NOTCH1(2), PSEN1(1) 740733 6 5 6 12 4 1 0 0 1 0 0.999 1.000 1.000 585 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSS(1), POLD1(2), POLG(2), RRM1(1), SRM(1) 957892 7 5 6 15 2 2 1 2 0 0 1.000 1.000 1.000 586 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 IDH1(1), MDH2(5) 647342 6 5 4 9 1 4 1 0 0 0 0.996 1.000 1.000 587 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4) 997709 8 5 8 39 1 4 0 3 0 0 1.000 1.000 1.000 588 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(3), MBTPS1(1), SCAP(3), SREBF1(1), SREBF2(5) 931385 13 5 8 13 4 4 0 5 0 0 0.991 1.000 1.000 589 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(2), LARS(4), PDHA2(2) 724252 8 5 5 24 0 7 1 0 0 0 1.000 1.000 1.000 590 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH4(4), ADH7(2), ADHFE1(1) 405117 7 4 4 11 0 2 1 2 2 0 0.999 1.000 1.000 591 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 GNAS(1), GNGT1(1), PPP2CA(1), PRKAA1(1), PRKACG(2) 1146405 6 4 5 21 2 2 0 2 0 0 1.000 1.000 1.000 592 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(3) 388880 5 4 3 7 1 4 0 0 0 0 0.983 1.000 1.000 593 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(7) 132232 7 4 5 4 4 3 0 0 0 0 0.794 1.000 1.000 594 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1G(1), HDAC9(1), MEF2B(3), MEF2C(1) 634155 6 4 5 23 2 1 0 2 1 0 1.000 1.000 1.000 595 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(3), SNCAIP(1) 451128 4 4 4 5 0 0 0 4 0 0 0.996 1.000 1.000 596 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(3) 452082 4 4 3 9 2 0 0 2 0 0 1.000 1.000 1.000 597 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), ACAT2(1), OXCT1(2) 248068 5 4 4 5 1 1 1 2 0 0 0.975 1.000 1.000 598 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(1), GNGT1(1), PRKACG(2) 732388 4 3 3 19 2 0 0 2 0 0 1.000 1.000 1.000 599 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT1(1), FUT2(1) 455083 3 3 3 6 2 0 0 1 0 0 0.996 1.000 1.000 600 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), EHHADH(3) 356381 4 3 4 4 0 3 0 1 0 0 0.933 1.000 1.000 601 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 OPRK1(1), PRKACG(2) 943548 3 3 2 27 1 0 0 2 0 0 1.000 1.000 1.000 602 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(1), HK1(1) 674641 3 3 3 9 0 2 0 1 0 0 1.000 1.000 1.000 603 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 GNAS(1), GNGT1(1), PRKACA(1) 489989 3 3 3 6 3 0 0 0 0 0 0.998 1.000 1.000 604 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), UXS1(1) 371833 3 3 2 8 0 3 0 0 0 0 0.999 1.000 1.000 605 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), UXS1(1) 296956 3 3 2 8 0 3 0 0 0 0 0.999 1.000 1.000 606 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP8(3) 276675 4 3 4 11 2 0 0 1 1 0 1.000 1.000 1.000 607 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), THBS1(5) 517679 6 3 4 15 0 4 0 1 1 0 1.000 1.000 1.000 608 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 KEAP1(1), MAPK8(1) 680914 2 2 2 13 0 1 1 0 0 0 1.000 1.000 1.000 609 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(2) 372890 2 2 1 13 2 0 0 0 0 0 1.000 1.000 1.000 610 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(1) 273918 1 1 1 7 1 0 0 0 0 0 1.000 1.000 1.000 611 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB9A(1) 312573 1 1 1 6 0 1 0 0 0 0 1.000 1.000 1.000 612 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 FMOD(1) 260296 1 1 1 5 0 0 1 0 0 0 0.999 1.000 1.000 613 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 121917 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 36378 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 156741 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 109350 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000