Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.155 0.201 -9999.0 0.0 -0.431 47.0 47.0 IHH -0.213 0.259 -9999.0 0.0 -0.502 80.0 80.0 SHH Np/Cholesterol/GAS1 -0.067 0.13 -9999.0 0.0 -0.256 57.0 57.0 LRPAP1 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.067 0.13 0.255 57.0 -9999.0 0.0 57.0 SMO/beta Arrestin2 -0.181 0.225 -9999.0 0.0 -0.455 59.0 59.0 SMO -0.193 0.229 -9999.0 0.0 -0.472 61.0 61.0 AKT1 -0.083 0.153 -9999.0 0.0 -0.534 12.0 12.0 ARRB2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.007 0.084 -9999.0 0.0 -0.45 6.0 6.0 ADRBK1 0.024 0.019 0.269 1.0 -9999.0 0.0 1.0 heart looping -0.19 0.226 -9999.0 0.0 -0.463 62.0 62.0 STIL -0.189 0.197 -9999.0 0.0 -0.465 48.0 48.0 DHH N/PTCH2 0.03 0.041 -9999.0 0.0 -0.282 3.0 3.0 DHH N/PTCH1 -0.125 0.174 -9999.0 0.0 -0.357 46.0 46.0 PIK3CA 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.222 0.281 -9999.0 0.0 -0.639 45.0 45.0 determination of left/right symmetry -0.19 0.226 -9999.0 0.0 -0.463 62.0 62.0 PIK3R1 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.22 0.278 -9999.0 0.0 -0.634 45.0 45.0 IHH N/Hhip -0.267 0.228 -9999.0 0.0 -0.412 121.0 121.0 DHH N/Hhip -0.124 0.176 -9999.0 0.0 -0.322 81.0 81.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.19 0.226 -9999.0 0.0 -0.463 62.0 62.0 pancreas development -0.188 0.233 -9999.0 0.0 -0.449 81.0 81.0 HHAT 0.013 0.069 -9999.0 0.0 -0.45 4.0 4.0 PI3K 0.026 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.001 0.101 -9999.0 0.0 -0.442 9.0 9.0 somite specification -0.19 0.226 -9999.0 0.0 -0.463 62.0 62.0 SHH Np/Cholesterol/PTCH1 -0.17 0.211 -9999.0 0.0 -0.432 61.0 61.0 SHH Np/Cholesterol/PTCH2 -0.059 0.129 -9999.0 0.0 -0.257 51.0 51.0 SHH Np/Cholesterol/Megalin -0.062 0.125 -9999.0 0.0 -0.249 54.0 54.0 SHH -0.082 0.153 -9999.0 0.0 -0.333 48.0 48.0 catabolic process -0.149 0.187 -9999.0 0.0 -0.398 46.0 46.0 SMO/Vitamin D3 -0.191 0.235 -9999.0 0.0 -0.49 58.0 58.0 SHH Np/Cholesterol/Hhip -0.164 0.181 -9999.0 0.0 -0.317 98.0 98.0 LRP2 0.008 0.071 -9999.0 0.0 -0.373 6.0 6.0 receptor-mediated endocytosis -0.192 0.227 -9999.0 0.0 -0.514 46.0 46.0 SHH Np/Cholesterol/BOC -0.062 0.132 -9999.0 0.0 -0.263 51.0 51.0 SHH Np/Cholesterol/CDO -0.058 0.129 0.174 1.0 -0.258 51.0 52.0 mesenchymal cell differentiation 0.163 0.18 0.315 98.0 -9999.0 0.0 98.0 mol:Vitamin D3 -0.171 0.212 -9999.0 0.0 -0.433 61.0 61.0 IHH N/PTCH2 -0.12 0.171 -9999.0 0.0 -0.31 79.0 79.0 CDON 0.016 0.063 0.269 1.0 -0.45 3.0 4.0 IHH N/PTCH1 -0.147 0.193 -9999.0 0.0 -0.402 46.0 46.0 Megalin/LRPAP1 0.022 0.054 -9999.0 0.0 -0.261 6.0 6.0 PTCH2 0.018 0.054 -9999.0 0.0 -0.399 3.0 3.0 SHH Np/Cholesterol -0.06 0.12 -9999.0 0.0 -0.254 49.0 49.0 PTCH1 -0.149 0.188 -9999.0 0.0 -0.399 46.0 46.0 HHIP -0.189 0.233 -9999.0 0.0 -0.45 81.0 81.0