This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 10 different clustering approaches and 8 clinical features across 593 patients, 12 significant findings detected with P value < 0.05 and Q value < 0.25.
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CNMF clustering analysis on array-based mRNA expression data identified 4 subtypes that correlate to 'HISTOLOGICAL_TYPE'.
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Consensus hierarchical clustering analysis on array-based mRNA expression data identified 4 subtypes that correlate to 'Time to Death', 'YEARS_TO_BIRTH', and 'HISTOLOGICAL_TYPE'.
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CNMF clustering analysis on array-based miR expression data identified 4 subtypes that correlate to 'Time to Death'.
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Consensus hierarchical clustering analysis on array-based miR expression data identified 3 subtypes that do not correlate to any clinical features.
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3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'YEARS_TO_BIRTH' and 'RADIATION_THERAPY'.
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3 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', and 'KARNOFSKY_PERFORMANCE_SCORE'.
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CNMF clustering analysis on RPPA data identified 5 subtypes that do not correlate to any clinical features.
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Consensus hierarchical clustering analysis on RPPA data identified 3 subtypes that correlate to 'Time to Death'.
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CNMF clustering analysis on sequencing-based mRNA expression data identified 3 subtypes that do not correlate to any clinical features.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 3 subtypes that correlate to 'KARNOFSKY_PERFORMANCE_SCORE'.
Clinical Features |
Time to Death |
YEARS TO BIRTH |
GENDER |
RADIATION THERAPY |
KARNOFSKY PERFORMANCE SCORE |
HISTOLOGICAL TYPE |
RACE | ETHNICITY |
Statistical Tests | logrank test | Kruskal-Wallis (anova) | Fisher's exact test | Fisher's exact test | Kruskal-Wallis (anova) | Fisher's exact test | Fisher's exact test | Fisher's exact test |
mRNA CNMF subtypes |
0.0522 (0.278) |
0.0788 (0.3) |
0.4 (0.745) |
0.517 (0.811) |
0.474 (0.79) |
0.00474 (0.0542) |
0.834 (0.93) |
0.123 (0.377) |
mRNA cHierClus subtypes |
0.00017 (0.00452) |
0.00252 (0.0403) |
0.0926 (0.335) |
0.224 (0.528) |
0.515 (0.811) |
0.0302 (0.22) |
0.586 (0.876) |
0.682 (0.902) |
miR CNMF subtypes |
0.00335 (0.0447) |
0.38 (0.724) |
0.651 (0.902) |
0.352 (0.705) |
0.861 (0.93) |
0.362 (0.707) |
0.205 (0.513) |
0.855 (0.93) |
miR cHierClus subtypes |
0.194 (0.5) |
0.127 (0.377) |
0.151 (0.417) |
0.463 (0.788) |
0.278 (0.591) |
0.281 (0.591) |
0.192 (0.5) |
0.675 (0.902) |
Copy Number Ratio CNMF subtypes |
0.0435 (0.255) |
1.21e-05 (0.00097) |
0.49 (0.8) |
0.00551 (0.0551) |
0.103 (0.345) |
0.224 (0.528) |
0.12 (0.377) |
0.759 (0.906) |
METHLYATION CNMF |
0.000425 (0.0085) |
8.57e-05 (0.00343) |
0.601 (0.876) |
0.238 (0.528) |
0.0301 (0.22) |
0.302 (0.619) |
0.992 (0.992) |
0.893 (0.933) |
RPPA CNMF subtypes |
0.688 (0.902) |
0.856 (0.93) |
0.0616 (0.3) |
0.767 (0.906) |
0.988 (0.992) |
0.896 (0.933) |
0.987 (0.992) |
0.668 (0.902) |
RPPA cHierClus subtypes |
0.0238 (0.211) |
0.0447 (0.255) |
0.236 (0.528) |
0.647 (0.902) |
0.068 (0.3) |
0.732 (0.906) |
0.42 (0.747) |
0.781 (0.906) |
RNAseq CNMF subtypes |
0.45 (0.782) |
0.0964 (0.335) |
0.0701 (0.3) |
0.706 (0.906) |
0.41 (0.745) |
0.791 (0.906) |
0.792 (0.906) |
0.792 (0.906) |
RNAseq cHierClus subtypes |
0.0741 (0.3) |
0.0784 (0.3) |
0.145 (0.413) |
0.898 (0.933) |
0.0366 (0.244) |
0.602 (0.876) |
0.577 (0.876) |
0.738 (0.906) |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 154 | 97 | 156 | 118 |
P value = 0.0522 (logrank test), Q value = 0.28
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 525 | 447 | 0.1 - 127.6 (12.2) |
subtype1 | 154 | 138 | 0.1 - 127.6 (10.6) |
subtype2 | 97 | 81 | 0.2 - 115.9 (14.5) |
subtype3 | 156 | 128 | 0.1 - 94.8 (13.8) |
subtype4 | 118 | 100 | 0.2 - 91.8 (12.6) |
P value = 0.0788 (Kruskal-Wallis (anova)), Q value = 0.3
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 525 | 57.7 (14.6) |
subtype1 | 154 | 58.4 (12.4) |
subtype2 | 97 | 54.2 (17.4) |
subtype3 | 156 | 60.0 (13.3) |
subtype4 | 118 | 56.5 (15.7) |
P value = 0.4 (Fisher's exact test), Q value = 0.74
nPatients | FEMALE | MALE |
---|---|---|
ALL | 205 | 320 |
subtype1 | 59 | 95 |
subtype2 | 41 | 56 |
subtype3 | 66 | 90 |
subtype4 | 39 | 79 |
P value = 0.517 (Fisher's exact test), Q value = 0.81
nPatients | NO | YES |
---|---|---|
ALL | 70 | 435 |
subtype1 | 21 | 127 |
subtype2 | 14 | 79 |
subtype3 | 16 | 134 |
subtype4 | 19 | 95 |
P value = 0.474 (Kruskal-Wallis (anova)), Q value = 0.79
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 396 | 77.1 (14.6) |
subtype1 | 115 | 77.6 (15.8) |
subtype2 | 76 | 76.6 (11.0) |
subtype3 | 120 | 76.1 (15.4) |
subtype4 | 85 | 78.6 (14.7) |
P value = 0.00474 (Fisher's exact test), Q value = 0.054
nPatients | GLIOBLASTOMA MULTIFORME (GBM) | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|
ALL | 6 | 20 | 499 |
subtype1 | 1 | 8 | 145 |
subtype2 | 0 | 7 | 90 |
subtype3 | 0 | 4 | 152 |
subtype4 | 5 | 1 | 112 |
P value = 0.834 (Fisher's exact test), Q value = 0.93
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 13 | 31 | 462 |
subtype1 | 4 | 12 | 135 |
subtype2 | 2 | 7 | 84 |
subtype3 | 5 | 7 | 139 |
subtype4 | 2 | 5 | 104 |
P value = 0.123 (Fisher's exact test), Q value = 0.38
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 12 | 438 |
subtype1 | 3 | 131 |
subtype2 | 5 | 68 |
subtype3 | 3 | 135 |
subtype4 | 1 | 104 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 153 | 107 | 103 | 162 |
P value = 0.00017 (logrank test), Q value = 0.0045
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 525 | 447 | 0.1 - 127.6 (12.2) |
subtype1 | 153 | 138 | 0.1 - 91.0 (12.2) |
subtype2 | 107 | 80 | 0.2 - 115.9 (14.7) |
subtype3 | 103 | 87 | 0.1 - 94.8 (13.8) |
subtype4 | 162 | 142 | 0.1 - 127.6 (10.4) |
P value = 0.00252 (Kruskal-Wallis (anova)), Q value = 0.04
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 525 | 57.7 (14.6) |
subtype1 | 153 | 56.9 (13.6) |
subtype2 | 107 | 52.9 (17.9) |
subtype3 | 103 | 60.6 (12.1) |
subtype4 | 162 | 59.8 (13.7) |
P value = 0.0926 (Fisher's exact test), Q value = 0.34
nPatients | FEMALE | MALE |
---|---|---|
ALL | 205 | 320 |
subtype1 | 51 | 102 |
subtype2 | 44 | 63 |
subtype3 | 50 | 53 |
subtype4 | 60 | 102 |
P value = 0.224 (Fisher's exact test), Q value = 0.53
nPatients | NO | YES |
---|---|---|
ALL | 70 | 435 |
subtype1 | 17 | 131 |
subtype2 | 13 | 91 |
subtype3 | 11 | 88 |
subtype4 | 29 | 125 |
P value = 0.515 (Kruskal-Wallis (anova)), Q value = 0.81
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 396 | 77.1 (14.6) |
subtype1 | 118 | 78.1 (15.4) |
subtype2 | 84 | 77.6 (11.6) |
subtype3 | 81 | 75.2 (15.6) |
subtype4 | 113 | 77.3 (15.1) |
P value = 0.0302 (Fisher's exact test), Q value = 0.22
nPatients | GLIOBLASTOMA MULTIFORME (GBM) | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|
ALL | 6 | 20 | 499 |
subtype1 | 0 | 11 | 142 |
subtype2 | 1 | 3 | 103 |
subtype3 | 0 | 3 | 100 |
subtype4 | 5 | 3 | 154 |
P value = 0.586 (Fisher's exact test), Q value = 0.88
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 13 | 31 | 462 |
subtype1 | 4 | 13 | 130 |
subtype2 | 4 | 6 | 95 |
subtype3 | 3 | 4 | 93 |
subtype4 | 2 | 8 | 144 |
P value = 0.682 (Fisher's exact test), Q value = 0.9
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 12 | 438 |
subtype1 | 5 | 124 |
subtype2 | 1 | 91 |
subtype3 | 2 | 90 |
subtype4 | 4 | 133 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 165 | 182 | 90 | 124 |
P value = 0.00335 (logrank test), Q value = 0.045
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 561 | 466 | 0.1 - 127.6 (12.2) |
subtype1 | 165 | 141 | 0.1 - 91.0 (11.3) |
subtype2 | 182 | 147 | 0.1 - 127.6 (13.7) |
subtype3 | 90 | 74 | 0.4 - 65.3 (9.3) |
subtype4 | 124 | 104 | 0.1 - 120.6 (12.8) |
P value = 0.38 (Kruskal-Wallis (anova)), Q value = 0.72
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 561 | 57.9 (14.3) |
subtype1 | 165 | 59.8 (11.6) |
subtype2 | 182 | 55.7 (16.6) |
subtype3 | 90 | 58.5 (14.6) |
subtype4 | 124 | 58.1 (13.6) |
P value = 0.651 (Fisher's exact test), Q value = 0.9
nPatients | FEMALE | MALE |
---|---|---|
ALL | 218 | 343 |
subtype1 | 63 | 102 |
subtype2 | 76 | 106 |
subtype3 | 36 | 54 |
subtype4 | 43 | 81 |
P value = 0.352 (Fisher's exact test), Q value = 0.7
nPatients | NO | YES |
---|---|---|
ALL | 73 | 465 |
subtype1 | 19 | 141 |
subtype2 | 21 | 153 |
subtype3 | 17 | 70 |
subtype4 | 16 | 101 |
P value = 0.861 (Kruskal-Wallis (anova)), Q value = 0.93
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 428 | 77.4 (14.7) |
subtype1 | 129 | 76.1 (15.5) |
subtype2 | 132 | 77.4 (14.8) |
subtype3 | 74 | 78.2 (13.5) |
subtype4 | 93 | 78.3 (14.6) |
P value = 0.362 (Fisher's exact test), Q value = 0.71
nPatients | GLIOBLASTOMA MULTIFORME (GBM) | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|
ALL | 9 | 20 | 532 |
subtype1 | 2 | 4 | 159 |
subtype2 | 1 | 8 | 173 |
subtype3 | 3 | 5 | 82 |
subtype4 | 3 | 3 | 118 |
P value = 0.205 (Fisher's exact test), Q value = 0.51
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 13 | 30 | 493 |
subtype1 | 3 | 13 | 140 |
subtype2 | 7 | 9 | 157 |
subtype3 | 1 | 1 | 85 |
subtype4 | 2 | 7 | 111 |
P value = 0.855 (Fisher's exact test), Q value = 0.93
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 12 | 459 |
subtype1 | 5 | 134 |
subtype2 | 4 | 153 |
subtype3 | 1 | 71 |
subtype4 | 2 | 101 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 302 | 129 | 130 |
P value = 0.194 (logrank test), Q value = 0.5
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 561 | 466 | 0.1 - 127.6 (12.2) |
subtype1 | 302 | 252 | 0.1 - 120.6 (12.6) |
subtype2 | 129 | 107 | 0.1 - 92.7 (10.8) |
subtype3 | 130 | 107 | 0.1 - 127.6 (11.8) |
P value = 0.127 (Kruskal-Wallis (anova)), Q value = 0.38
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 561 | 57.9 (14.3) |
subtype1 | 302 | 56.5 (15.9) |
subtype2 | 129 | 59.0 (11.5) |
subtype3 | 130 | 60.0 (12.5) |
P value = 0.151 (Fisher's exact test), Q value = 0.42
nPatients | FEMALE | MALE |
---|---|---|
ALL | 218 | 343 |
subtype1 | 110 | 192 |
subtype2 | 48 | 81 |
subtype3 | 60 | 70 |
P value = 0.463 (Fisher's exact test), Q value = 0.79
nPatients | NO | YES |
---|---|---|
ALL | 73 | 465 |
subtype1 | 44 | 245 |
subtype2 | 13 | 109 |
subtype3 | 16 | 111 |
P value = 0.278 (Kruskal-Wallis (anova)), Q value = 0.59
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 428 | 77.4 (14.7) |
subtype1 | 227 | 78.5 (14.0) |
subtype2 | 101 | 76.5 (15.6) |
subtype3 | 100 | 75.5 (15.4) |
P value = 0.281 (Fisher's exact test), Q value = 0.59
nPatients | GLIOBLASTOMA MULTIFORME (GBM) | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|
ALL | 9 | 20 | 532 |
subtype1 | 6 | 13 | 283 |
subtype2 | 3 | 2 | 124 |
subtype3 | 0 | 5 | 125 |
P value = 0.192 (Fisher's exact test), Q value = 0.5
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 13 | 30 | 493 |
subtype1 | 7 | 10 | 272 |
subtype2 | 3 | 11 | 113 |
subtype3 | 3 | 9 | 108 |
P value = 0.675 (Fisher's exact test), Q value = 0.9
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 12 | 459 |
subtype1 | 6 | 249 |
subtype2 | 2 | 109 |
subtype3 | 4 | 101 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 161 | 217 | 193 |
P value = 0.0435 (logrank test), Q value = 0.26
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 570 | 470 | 0.1 - 127.6 (12.2) |
subtype1 | 161 | 140 | 0.1 - 127.6 (10.6) |
subtype2 | 217 | 179 | 0.1 - 120.6 (12.6) |
subtype3 | 192 | 151 | 0.2 - 115.9 (12.6) |
P value = 1.21e-05 (Kruskal-Wallis (anova)), Q value = 0.00097
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 571 | 57.7 (14.5) |
subtype1 | 161 | 60.5 (13.5) |
subtype2 | 217 | 60.1 (10.7) |
subtype3 | 193 | 52.9 (17.5) |
P value = 0.49 (Fisher's exact test), Q value = 0.8
nPatients | FEMALE | MALE |
---|---|---|
ALL | 224 | 347 |
subtype1 | 69 | 92 |
subtype2 | 80 | 137 |
subtype3 | 75 | 118 |
P value = 0.00551 (Fisher's exact test), Q value = 0.055
nPatients | NO | YES |
---|---|---|
ALL | 74 | 474 |
subtype1 | 33 | 122 |
subtype2 | 22 | 185 |
subtype3 | 19 | 167 |
P value = 0.103 (Kruskal-Wallis (anova)), Q value = 0.34
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 424 | 77.4 (14.9) |
subtype1 | 115 | 75.7 (14.6) |
subtype2 | 166 | 77.3 (15.6) |
subtype3 | 143 | 79.0 (14.3) |
P value = 0.224 (Fisher's exact test), Q value = 0.53
nPatients | GLIOBLASTOMA MULTIFORME (GBM) | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|
ALL | 28 | 18 | 525 |
subtype1 | 5 | 4 | 152 |
subtype2 | 9 | 5 | 203 |
subtype3 | 14 | 9 | 170 |
P value = 0.12 (Fisher's exact test), Q value = 0.38
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 13 | 50 | 485 |
subtype1 | 1 | 15 | 139 |
subtype2 | 3 | 17 | 188 |
subtype3 | 9 | 18 | 158 |
P value = 0.759 (Fisher's exact test), Q value = 0.91
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 12 | 473 |
subtype1 | 2 | 134 |
subtype2 | 5 | 176 |
subtype3 | 5 | 163 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 92 | 110 | 81 |
P value = 0.000425 (logrank test), Q value = 0.0085
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 283 | 227 | 0.1 - 127.6 (12.2) |
subtype1 | 92 | 73 | 0.1 - 92.7 (11.8) |
subtype2 | 110 | 94 | 0.1 - 77.7 (10.5) |
subtype3 | 81 | 60 | 0.2 - 127.6 (14.3) |
P value = 8.57e-05 (Kruskal-Wallis (anova)), Q value = 0.0034
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 283 | 57.8 (15.0) |
subtype1 | 92 | 59.0 (12.9) |
subtype2 | 110 | 61.8 (12.6) |
subtype3 | 81 | 51.1 (17.8) |
P value = 0.601 (Fisher's exact test), Q value = 0.88
nPatients | FEMALE | MALE |
---|---|---|
ALL | 115 | 168 |
subtype1 | 41 | 51 |
subtype2 | 44 | 66 |
subtype3 | 30 | 51 |
P value = 0.238 (Fisher's exact test), Q value = 0.53
nPatients | NO | YES |
---|---|---|
ALL | 39 | 234 |
subtype1 | 10 | 79 |
subtype2 | 20 | 85 |
subtype3 | 9 | 70 |
P value = 0.0301 (Kruskal-Wallis (anova)), Q value = 0.22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 216 | 75.4 (15.3) |
subtype1 | 71 | 77.0 (17.7) |
subtype2 | 81 | 72.6 (14.6) |
subtype3 | 64 | 77.2 (13.0) |
P value = 0.302 (Fisher's exact test), Q value = 0.62
nPatients | GLIOBLASTOMA MULTIFORME (GBM) | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|
ALL | 3 | 19 | 261 |
subtype1 | 3 | 6 | 83 |
subtype2 | 0 | 7 | 103 |
subtype3 | 0 | 6 | 75 |
P value = 0.992 (Fisher's exact test), Q value = 0.99
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 10 | 16 | 254 |
subtype1 | 3 | 6 | 82 |
subtype2 | 4 | 6 | 98 |
subtype3 | 3 | 4 | 74 |
P value = 0.893 (Fisher's exact test), Q value = 0.93
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 7 | 232 |
subtype1 | 3 | 80 |
subtype2 | 2 | 88 |
subtype3 | 2 | 64 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 46 | 60 | 46 | 30 | 48 |
P value = 0.688 (logrank test), Q value = 0.9
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 229 | 170 | 0.1 - 120.6 (10.9) |
subtype1 | 46 | 35 | 0.2 - 47.6 (9.1) |
subtype2 | 60 | 48 | 0.1 - 53.2 (12.5) |
subtype3 | 45 | 32 | 0.5 - 115.9 (8.3) |
subtype4 | 30 | 21 | 0.2 - 43.5 (10.6) |
subtype5 | 48 | 34 | 0.1 - 120.6 (10.9) |
P value = 0.856 (Kruskal-Wallis (anova)), Q value = 0.93
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 230 | 59.4 (14.3) |
subtype1 | 46 | 59.4 (12.9) |
subtype2 | 60 | 59.5 (12.9) |
subtype3 | 46 | 56.9 (17.3) |
subtype4 | 30 | 60.1 (15.3) |
subtype5 | 48 | 61.4 (13.5) |
P value = 0.0616 (Fisher's exact test), Q value = 0.3
nPatients | FEMALE | MALE |
---|---|---|
ALL | 91 | 139 |
subtype1 | 13 | 33 |
subtype2 | 19 | 41 |
subtype3 | 19 | 27 |
subtype4 | 14 | 16 |
subtype5 | 26 | 22 |
P value = 0.767 (Fisher's exact test), Q value = 0.91
nPatients | NO | YES |
---|---|---|
ALL | 29 | 186 |
subtype1 | 6 | 39 |
subtype2 | 5 | 48 |
subtype3 | 8 | 35 |
subtype4 | 4 | 23 |
subtype5 | 6 | 41 |
P value = 0.988 (Kruskal-Wallis (anova)), Q value = 0.99
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 176 | 75.5 (15.8) |
subtype1 | 35 | 74.0 (20.3) |
subtype2 | 46 | 75.4 (12.4) |
subtype3 | 35 | 75.7 (17.7) |
subtype4 | 22 | 75.9 (15.9) |
subtype5 | 38 | 76.3 (13.4) |
P value = 0.896 (Fisher's exact test), Q value = 0.93
nPatients | GLIOBLASTOMA MULTIFORME (GBM) | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|
ALL | 17 | 3 | 210 |
subtype1 | 3 | 0 | 43 |
subtype2 | 3 | 2 | 55 |
subtype3 | 4 | 0 | 42 |
subtype4 | 2 | 0 | 28 |
subtype5 | 5 | 1 | 42 |
P value = 0.987 (Fisher's exact test), Q value = 0.99
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 4 | 27 | 183 |
subtype1 | 0 | 6 | 37 |
subtype2 | 1 | 8 | 47 |
subtype3 | 1 | 4 | 36 |
subtype4 | 1 | 3 | 23 |
subtype5 | 1 | 6 | 40 |
P value = 0.668 (Fisher's exact test), Q value = 0.9
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 3 | 194 |
subtype1 | 1 | 40 |
subtype2 | 2 | 48 |
subtype3 | 0 | 40 |
subtype4 | 0 | 25 |
subtype5 | 0 | 41 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 93 | 76 | 61 |
P value = 0.0238 (logrank test), Q value = 0.21
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 229 | 170 | 0.1 - 120.6 (10.9) |
subtype1 | 93 | 74 | 0.2 - 53.2 (8.4) |
subtype2 | 75 | 50 | 0.1 - 115.9 (9.7) |
subtype3 | 61 | 46 | 0.1 - 120.6 (13.9) |
P value = 0.0447 (Kruskal-Wallis (anova)), Q value = 0.26
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 230 | 59.4 (14.3) |
subtype1 | 93 | 61.2 (13.2) |
subtype2 | 76 | 55.2 (16.7) |
subtype3 | 61 | 62.1 (11.2) |
P value = 0.236 (Fisher's exact test), Q value = 0.53
nPatients | FEMALE | MALE |
---|---|---|
ALL | 91 | 139 |
subtype1 | 34 | 59 |
subtype2 | 36 | 40 |
subtype3 | 21 | 40 |
P value = 0.647 (Fisher's exact test), Q value = 0.9
nPatients | NO | YES |
---|---|---|
ALL | 29 | 186 |
subtype1 | 14 | 73 |
subtype2 | 9 | 62 |
subtype3 | 6 | 51 |
P value = 0.068 (Kruskal-Wallis (anova)), Q value = 0.3
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 176 | 75.5 (15.8) |
subtype1 | 69 | 72.3 (17.1) |
subtype2 | 61 | 78.5 (15.6) |
subtype3 | 46 | 76.1 (13.4) |
P value = 0.732 (Fisher's exact test), Q value = 0.91
nPatients | GLIOBLASTOMA MULTIFORME (GBM) | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|
ALL | 17 | 3 | 210 |
subtype1 | 8 | 2 | 83 |
subtype2 | 6 | 0 | 70 |
subtype3 | 3 | 1 | 57 |
P value = 0.42 (Fisher's exact test), Q value = 0.75
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 4 | 27 | 183 |
subtype1 | 0 | 13 | 73 |
subtype2 | 2 | 7 | 60 |
subtype3 | 2 | 7 | 50 |
P value = 0.781 (Fisher's exact test), Q value = 0.91
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 3 | 194 |
subtype1 | 2 | 75 |
subtype2 | 1 | 65 |
subtype3 | 0 | 54 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 47 | 70 | 35 |
P value = 0.45 (logrank test), Q value = 0.78
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 152 | 118 | 0.2 - 88.1 (10.9) |
subtype1 | 47 | 34 | 0.2 - 88.1 (10.9) |
subtype2 | 70 | 55 | 0.9 - 69.9 (10.9) |
subtype3 | 35 | 29 | 0.2 - 46.9 (10.8) |
P value = 0.0964 (Kruskal-Wallis (anova)), Q value = 0.34
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 152 | 59.7 (13.5) |
subtype1 | 47 | 55.6 (16.6) |
subtype2 | 70 | 62.0 (10.6) |
subtype3 | 35 | 60.9 (13.3) |
P value = 0.0701 (Fisher's exact test), Q value = 0.3
nPatients | FEMALE | MALE |
---|---|---|
ALL | 53 | 99 |
subtype1 | 14 | 33 |
subtype2 | 31 | 39 |
subtype3 | 8 | 27 |
P value = 0.706 (Fisher's exact test), Q value = 0.91
nPatients | NO | YES |
---|---|---|
ALL | 23 | 121 |
subtype1 | 6 | 38 |
subtype2 | 10 | 56 |
subtype3 | 7 | 27 |
P value = 0.41 (Kruskal-Wallis (anova)), Q value = 0.74
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 117 | 75.7 (14.8) |
subtype1 | 38 | 75.0 (15.2) |
subtype2 | 53 | 74.5 (13.8) |
subtype3 | 26 | 79.2 (16.0) |
P value = 0.791 (Fisher's exact test), Q value = 0.91
nPatients | GLIOBLASTOMA MULTIFORME (GBM) | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|
ALL | 1 | 1 | 150 |
subtype1 | 1 | 0 | 46 |
subtype2 | 0 | 1 | 69 |
subtype3 | 0 | 0 | 35 |
P value = 0.792 (Fisher's exact test), Q value = 0.91
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 5 | 10 | 136 |
subtype1 | 2 | 3 | 42 |
subtype2 | 1 | 5 | 63 |
subtype3 | 2 | 2 | 31 |
P value = 0.792 (Fisher's exact test), Q value = 0.91
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 3 | 125 |
subtype1 | 1 | 44 |
subtype2 | 2 | 51 |
subtype3 | 0 | 30 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 32 | 96 | 24 |
P value = 0.0741 (logrank test), Q value = 0.3
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 152 | 118 | 0.2 - 88.1 (10.9) |
subtype1 | 32 | 22 | 0.2 - 88.1 (13.8) |
subtype2 | 96 | 76 | 0.4 - 69.9 (10.1) |
subtype3 | 24 | 20 | 0.2 - 46.9 (8.9) |
P value = 0.0784 (Kruskal-Wallis (anova)), Q value = 0.3
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 152 | 59.7 (13.5) |
subtype1 | 32 | 54.2 (18.3) |
subtype2 | 96 | 61.6 (11.4) |
subtype3 | 24 | 59.6 (12.5) |
P value = 0.145 (Fisher's exact test), Q value = 0.41
nPatients | FEMALE | MALE |
---|---|---|
ALL | 53 | 99 |
subtype1 | 9 | 23 |
subtype2 | 39 | 57 |
subtype3 | 5 | 19 |
P value = 0.898 (Fisher's exact test), Q value = 0.93
nPatients | NO | YES |
---|---|---|
ALL | 23 | 121 |
subtype1 | 4 | 27 |
subtype2 | 15 | 74 |
subtype3 | 4 | 20 |
P value = 0.0366 (Kruskal-Wallis (anova)), Q value = 0.24
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 117 | 75.7 (14.8) |
subtype1 | 26 | 78.1 (11.7) |
subtype2 | 75 | 73.3 (14.6) |
subtype3 | 16 | 83.1 (17.4) |
P value = 0.602 (Fisher's exact test), Q value = 0.88
nPatients | GLIOBLASTOMA MULTIFORME (GBM) | TREATED PRIMARY GBM | UNTREATED PRIMARY (DE NOVO) GBM |
---|---|---|---|
ALL | 1 | 1 | 150 |
subtype1 | 1 | 0 | 31 |
subtype2 | 0 | 1 | 95 |
subtype3 | 0 | 0 | 24 |
P value = 0.577 (Fisher's exact test), Q value = 0.88
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 5 | 10 | 136 |
subtype1 | 2 | 1 | 29 |
subtype2 | 2 | 8 | 85 |
subtype3 | 1 | 1 | 22 |
P value = 0.738 (Fisher's exact test), Q value = 0.91
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 3 | 125 |
subtype1 | 0 | 30 |
subtype2 | 3 | 75 |
subtype3 | 0 | 20 |
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Cluster data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_mergedClustering/GBM-TP/20125497/GBM-TP.mergedcluster.txt
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Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/GBM-TP/19775175/GBM-TP.merged_data.txt
-
Number of patients = 593
-
Number of clustering approaches = 10
-
Number of selected clinical features = 8
-
Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.