E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.041 0.14 -9999.0 0.0 -0.364 24.0 24.0 KLHL20 -0.004 0.061 -9999.0 0.0 -0.233 3.0 3.0 CYFIP2 0.007 0.027 -9999.0 0.0 -0.326 1.0 1.0 Rac1/GDP -0.015 0.088 -9999.0 0.0 -0.211 25.0 25.0 ENAH -0.041 0.14 -9999.0 0.0 -0.364 24.0 24.0 AP1M1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.01 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.008 0.055 -9999.0 0.0 -0.232 1.0 1.0 ABI1/Sra1/Nap1 -0.016 0.037 -9999.0 0.0 -0.153 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.006 0.071 -9999.0 0.0 -0.157 27.0 27.0 RAPGEF1 -0.035 0.126 -9999.0 0.0 -0.323 24.0 24.0 CTNND1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.043 0.144 -9999.0 0.0 -0.375 24.0 24.0 CRK -0.038 0.132 -9999.0 0.0 -0.343 24.0 24.0 E-cadherin/gamma catenin/alpha catenin -0.011 0.074 -9999.0 0.0 -0.177 25.0 25.0 alphaE/beta7 Integrin 0.01 0.033 -9999.0 0.0 -0.22 3.0 3.0 IQGAP1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.041 0.14 -9999.0 0.0 -0.364 24.0 24.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.037 -9999.0 0.0 -0.168 1.0 1.0 MLLT4 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.017 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.021 0.046 -9999.0 0.0 -0.215 1.0 1.0 ARF6 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.021 0.087 -9999.0 0.0 -0.216 25.0 25.0 TIAM1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.003 0.064 -9999.0 0.0 -0.149 24.0 24.0 AKT1 -0.001 0.033 -9999.0 0.0 -0.126 1.0 1.0 PIK3R1 0.007 0.028 -9999.0 0.0 -0.326 1.0 1.0 CDH1 -0.039 0.125 -9999.0 0.0 -0.326 24.0 24.0 RhoA/GDP -0.015 0.088 -9999.0 0.0 -0.211 25.0 25.0 actin cytoskeleton organization -0.002 0.046 -9999.0 0.0 -0.1 25.0 25.0 CDC42/GDP -0.015 0.088 -9999.0 0.0 -0.211 25.0 25.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.018 0.072 -9999.0 0.0 -0.179 25.0 25.0 ITGB7 0.003 0.047 -9999.0 0.0 -0.326 3.0 3.0 RAC1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.003 0.068 -9999.0 0.0 -0.159 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.008 0.062 -9999.0 0.0 -0.15 24.0 24.0 mol:GDP -0.023 0.099 -9999.0 0.0 -0.242 25.0 25.0 CDC42/GTP/IQGAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.008 0.028 -9999.0 0.0 -0.326 1.0 1.0 p120 catenin/RhoA/GDP -0.014 0.09 -9999.0 0.0 -0.214 25.0 25.0 RAC1/GTP/IQGAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.012 0.019 -9999.0 0.0 -0.22 1.0 1.0 RHOA 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.002 0.033 0.082 4.0 -0.109 3.0 7.0 NME1 0.009 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.041 0.14 -9999.0 0.0 -0.364 24.0 24.0 regulation of cell-cell adhesion -0.019 0.044 -9999.0 0.0 -0.206 1.0 1.0 WASF2 -0.001 0.024 -9999.0 0.0 -0.082 4.0 4.0 Rap1/GTP -0.007 0.062 -9999.0 0.0 -0.146 24.0 24.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.002 0.068 -9999.0 0.0 -0.143 28.0 28.0 CCND1 0.002 0.039 0.095 4.0 -0.132 3.0 7.0 VAV2 -0.046 0.164 -9999.0 0.0 -0.387 26.0 26.0 RAP1/GDP -0.007 0.073 -9999.0 0.0 -0.169 25.0 25.0 adherens junction assembly -0.039 0.136 -9999.0 0.0 -0.353 24.0 24.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.007 0.027 -9999.0 0.0 -0.326 1.0 1.0 regulation of heterotypic cell-cell adhesion -0.002 0.064 -9999.0 0.0 -0.139 24.0 24.0 E-cadherin/beta catenin -0.035 0.102 -9999.0 0.0 -0.264 25.0 25.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.041 0.14 -9999.0 0.0 -0.364 24.0 24.0 PIK3CA 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.032 0.083 -9999.0 0.0 -0.381 3.0 3.0 E-cadherin/beta catenin/alpha catenin -0.01 0.074 -9999.0 0.0 -0.18 24.0 24.0 ITGAE 0.01 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.044 0.147 -9999.0 0.0 -0.383 24.0 24.0