Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.004 0.127 -9999.0 0.0 -0.448 11.0 11.0 IHH 0.008 0.035 -9999.0 0.0 -0.108 11.0 11.0 SHH Np/Cholesterol/GAS1 -0.004 0.07 0.099 4.0 -0.165 22.0 26.0 LRPAP1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.004 0.07 0.164 22.0 -0.098 4.0 26.0 SMO/beta Arrestin2 0.004 0.09 -9999.0 0.0 -0.295 11.0 11.0 SMO -0.0 0.094 -9999.0 0.0 -0.311 11.0 11.0 AKT1 0.01 0.061 -9999.0 0.0 -0.497 1.0 1.0 ARRB2 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.028 -9999.0 0.0 -0.326 1.0 1.0 ADRBK1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.0 0.093 -9999.0 0.0 -0.307 11.0 11.0 STIL -0.006 0.085 -9999.0 0.0 -0.236 11.0 11.0 DHH N/PTCH2 0.003 0.056 -9999.0 0.0 -0.215 9.0 9.0 DHH N/PTCH1 0.005 0.087 -9999.0 0.0 -0.24 15.0 15.0 PIK3CA 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.002 0.063 -9999.0 0.0 -0.326 5.0 5.0 PTHLH -0.008 0.145 -9999.0 0.0 -0.504 11.0 11.0 determination of left/right symmetry 0.0 0.093 -9999.0 0.0 -0.307 11.0 11.0 PIK3R1 0.007 0.028 -9999.0 0.0 -0.326 1.0 1.0 skeletal system development -0.007 0.144 -9999.0 0.0 -0.5 11.0 11.0 IHH N/Hhip -0.014 0.097 0.118 1.0 -0.254 20.0 21.0 DHH N/Hhip -0.016 0.095 0.124 3.0 -0.226 24.0 27.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.0 0.093 -9999.0 0.0 -0.307 11.0 11.0 pancreas development -0.026 0.118 -9999.0 0.0 -0.325 20.0 20.0 HHAT 0.0 0.054 -9999.0 0.0 -0.326 4.0 4.0 PI3K 0.012 0.019 -9999.0 0.0 -0.22 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.006 0.058 -9999.0 0.0 -0.326 4.0 4.0 somite specification 0.0 0.093 -9999.0 0.0 -0.307 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.005 0.091 -9999.0 0.0 -0.249 11.0 11.0 SHH Np/Cholesterol/PTCH2 -0.008 0.07 -9999.0 0.0 -0.174 21.0 21.0 SHH Np/Cholesterol/Megalin -0.035 0.098 0.099 2.0 -0.173 46.0 48.0 SHH -0.011 0.081 -9999.0 0.0 -0.218 19.0 19.0 catabolic process 0.004 0.088 -9999.0 0.0 -0.298 11.0 11.0 SMO/Vitamin D3 -0.005 0.1 -9999.0 0.0 -0.295 10.0 10.0 SHH Np/Cholesterol/Hhip -0.021 0.087 0.099 3.0 -0.169 36.0 39.0 LRP2 -0.054 0.145 -9999.0 0.0 -0.326 33.0 33.0 receptor-mediated endocytosis -0.036 0.121 -9999.0 0.0 -0.313 16.0 16.0 SHH Np/Cholesterol/BOC -0.004 0.062 -9999.0 0.0 -0.159 20.0 20.0 SHH Np/Cholesterol/CDO -0.006 0.065 -9999.0 0.0 -0.16 22.0 22.0 mesenchymal cell differentiation 0.021 0.087 0.168 36.0 -0.098 3.0 39.0 mol:Vitamin D3 -0.004 0.091 -9999.0 0.0 -0.25 11.0 11.0 IHH N/PTCH2 0.007 0.047 -9999.0 0.0 -0.252 4.0 4.0 CDON 0.004 0.048 -9999.0 0.0 -0.326 3.0 3.0 IHH N/PTCH1 0.008 0.09 -9999.0 0.0 -0.3 11.0 11.0 Megalin/LRPAP1 -0.03 0.101 -9999.0 0.0 -0.22 33.0 33.0 PTCH2 0.0 0.054 -9999.0 0.0 -0.326 4.0 4.0 SHH Np/Cholesterol -0.015 0.055 -9999.0 0.0 -0.161 19.0 19.0 PTCH1 0.004 0.089 -9999.0 0.0 -0.299 11.0 11.0 HHIP -0.027 0.118 -9999.0 0.0 -0.326 20.0 20.0