Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.016 0.072 -9999.0 0.0 -0.178 25.0 25.0 epithelial cell differentiation -0.005 0.062 -9999.0 0.0 -0.148 24.0 24.0 CYFIP2 0.007 0.027 -9999.0 0.0 -0.326 1.0 1.0 ENAH -0.001 0.042 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.05 0.15 -9999.0 0.0 -0.326 34.0 34.0 EPHA2 0.008 0.029 -9999.0 0.0 -0.326 1.0 1.0 MYO6 -0.01 0.056 -9999.0 0.0 -0.139 24.0 24.0 CTNNB1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.017 0.016 -9999.0 0.0 -0.18 1.0 1.0 AQP5 -0.082 0.177 -9999.0 0.0 -0.413 32.0 32.0 CTNND1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.01 0.056 -9999.0 0.0 -0.138 24.0 24.0 regulation of calcium-dependent cell-cell adhesion -0.012 0.062 -9999.0 0.0 -0.15 24.0 24.0 EGF -0.014 0.087 -9999.0 0.0 -0.326 11.0 11.0 NCKAP1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.014 0.083 -9999.0 0.0 -0.371 5.0 5.0 cortical microtubule organization -0.005 0.062 -9999.0 0.0 -0.148 24.0 24.0 GO:0000145 -0.011 0.052 -9999.0 0.0 -0.132 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.003 0.064 -9999.0 0.0 -0.149 24.0 24.0 MLLT4 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.044 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.021 0.022 -9999.0 0.0 -0.159 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.007 0.054 -9999.0 0.0 -0.129 24.0 24.0 PVRL2 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.01 0.056 -9999.0 0.0 -0.139 24.0 24.0 ARF6/GTP 0.023 0.02 -9999.0 0.0 -0.146 2.0 2.0 CDH1 -0.039 0.125 -9999.0 0.0 -0.326 24.0 24.0 EGFR/EGFR/EGF/EGF -0.043 0.099 -9999.0 0.0 -0.168 50.0 50.0 RhoA/GDP -0.004 0.059 -9999.0 0.0 -0.138 24.0 24.0 actin cytoskeleton organization -0.01 0.056 -9999.0 0.0 -0.139 24.0 24.0 IGF-1R heterotetramer 0.01 0.009 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.001 0.067 -9999.0 0.0 -0.326 6.0 6.0 DIAPH1 0.014 0.049 -9999.0 0.0 -0.588 1.0 1.0 Wnt receptor signaling pathway 0.005 0.062 0.148 24.0 -9999.0 0.0 24.0 RHOA 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.045 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.01 0.057 -9999.0 0.0 -0.142 24.0 24.0 EFNA1 0.007 0.027 -9999.0 0.0 -0.326 1.0 1.0 LPP -0.009 0.054 -9999.0 0.0 -0.132 24.0 24.0 Ephrin A1/EPHA2 -0.007 0.058 -9999.0 0.0 -0.133 26.0 26.0 SEC6/SEC8 -0.019 0.045 -9999.0 0.0 -0.124 24.0 24.0 MGAT3 -0.012 0.063 -9999.0 0.0 -0.151 24.0 24.0 HGF/MET -0.039 0.092 -9999.0 0.0 -0.168 42.0 42.0 HGF -0.028 0.114 -9999.0 0.0 -0.326 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.016 0.072 -9999.0 0.0 -0.179 25.0 25.0 actin cable formation 0.007 0.043 -9999.0 0.0 -0.159 1.0 1.0 KIAA1543 -0.013 0.081 -9999.0 0.0 -0.183 24.0 24.0 KIFC3 -0.01 0.056 -9999.0 0.0 -0.139 24.0 24.0 NCK1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.01 0.056 -9999.0 0.0 -0.139 24.0 24.0 NCK1/GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.005 0.062 -9999.0 0.0 -0.148 24.0 24.0 EXOC4 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.01 0.056 -9999.0 0.0 -0.139 24.0 24.0 PIP5K1C -0.01 0.056 -9999.0 0.0 -0.139 24.0 24.0 LIMA1 0.007 0.027 -9999.0 0.0 -0.326 1.0 1.0 ABI1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.002 0.048 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.042 0.123 -9999.0 0.0 -0.375 10.0 10.0 IGF-1R heterotetramer/IGF1 -0.01 0.062 -9999.0 0.0 -0.139 25.0 25.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.024 0.12 -9999.0 0.0 -0.326 20.0 20.0 PLEKHA7 -0.011 0.063 -9999.0 0.0 -0.15 24.0 24.0 mol:GTP 0.02 0.022 -9999.0 0.0 -0.159 2.0 2.0 establishment of epithelial cell apical/basal polarity -0.003 0.05 -9999.0 0.0 -0.119 24.0 24.0 cortical actin cytoskeleton stabilization -0.016 0.072 -9999.0 0.0 -0.178 25.0 25.0 regulation of cell-cell adhesion -0.01 0.056 -9999.0 0.0 -0.139 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.016 0.072 -9999.0 0.0 -0.179 25.0 25.0