E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.045 0.15 -9999.0 0.0 -0.381 24.0 24.0 KLHL20 0.018 0.095 0.199 7.0 -0.236 3.0 10.0 CYFIP2 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.018 0.099 0.256 1.0 -0.246 19.0 20.0 ENAH -0.044 0.148 -9999.0 0.0 -0.374 24.0 24.0 AP1M1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.037 0.07 0.125 8.0 -0.269 1.0 9.0 ABI1/Sra1/Nap1 -0.024 0.041 -9999.0 0.0 -0.164 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.032 0.096 -9999.0 0.0 -0.18 24.0 24.0 RAPGEF1 -0.042 0.142 0.219 1.0 -0.359 21.0 22.0 CTNND1 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.036 0.156 -9999.0 0.0 -0.386 24.0 24.0 CRK -0.04 0.147 0.202 1.0 -0.37 22.0 23.0 E-cadherin/gamma catenin/alpha catenin 0.018 0.094 -9999.0 0.0 -0.193 24.0 24.0 alphaE/beta7 Integrin 0.04 0.032 -9999.0 0.0 -0.219 2.0 2.0 IQGAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.022 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.046 0.15 -9999.0 0.0 -0.381 24.0 24.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.039 0.043 -9999.0 0.0 -0.138 20.0 20.0 MLLT4 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.053 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.048 0.055 -9999.0 0.0 -0.175 20.0 20.0 ARF6 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.001 0.1 -9999.0 0.0 -0.225 24.0 24.0 TIAM1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.03 0.089 -9999.0 0.0 -0.172 23.0 23.0 AKT1 -0.02 0.053 0.149 2.0 -0.153 1.0 3.0 PIK3R1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.024 0.13 -9999.0 0.0 -0.325 23.0 23.0 RhoA/GDP -0.016 0.111 0.256 1.0 -0.245 21.0 22.0 actin cytoskeleton organization 0.017 0.074 0.165 7.0 -0.171 3.0 10.0 CDC42/GDP -0.017 0.111 0.256 1.0 -0.245 21.0 22.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.016 0.076 -9999.0 0.0 -0.188 24.0 24.0 ITGB7 0.025 0.041 -9999.0 0.0 -0.325 2.0 2.0 RAC1 0.02 0.014 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.033 0.095 -9999.0 0.0 -0.184 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.017 0.08 -9999.0 0.0 -0.166 23.0 23.0 mol:GDP -0.031 0.118 0.26 1.0 -0.276 21.0 22.0 CDC42/GTP/IQGAP1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.03 -9999.0 0.0 -0.325 1.0 1.0 p120 catenin/RhoA/GDP -0.006 0.118 0.26 1.0 -0.252 21.0 22.0 RAC1/GTP/IQGAP1 0.027 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.025 -9999.0 0.0 -0.231 1.0 1.0 RHOA 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.012 0.051 0.116 6.0 -0.119 2.0 8.0 NME1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.044 0.148 -9999.0 0.0 -0.385 23.0 23.0 regulation of cell-cell adhesion -0.04 0.051 -9999.0 0.0 -0.157 20.0 20.0 WASF2 0.0 0.04 0.084 5.0 -0.097 2.0 7.0 Rap1/GTP -0.033 0.081 0.161 9.0 -0.296 1.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.041 0.098 -9999.0 0.0 -0.171 24.0 24.0 CCND1 0.013 0.06 0.132 6.0 -0.145 2.0 8.0 VAV2 -0.047 0.201 -9999.0 0.0 -0.664 7.0 7.0 RAP1/GDP -0.006 0.095 0.2 1.0 -0.272 2.0 3.0 adherens junction assembly -0.044 0.145 -9999.0 0.0 -0.374 23.0 23.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.03 -9999.0 0.0 -0.325 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.021 0.088 0.209 1.0 -0.176 21.0 22.0 E-cadherin/beta catenin -0.039 0.103 -9999.0 0.0 -0.273 23.0 23.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.045 0.146 -9999.0 0.0 -0.385 22.0 22.0 PIK3CA 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.033 0.095 -9999.0 0.0 -0.38 3.0 3.0 E-cadherin/beta catenin/alpha catenin 0.019 0.094 -9999.0 0.0 -0.198 23.0 23.0 ITGAE 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.037 0.159 -9999.0 0.0 -0.393 24.0 24.0