Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.004 0.113 -9999.0 0.0 -0.44 8.0 8.0 IHH 0.027 0.045 0.12 1.0 -0.129 10.0 11.0 SHH Np/Cholesterol/GAS1 -0.006 0.063 -9999.0 0.0 -0.185 13.0 13.0 LRPAP1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.006 0.062 0.184 13.0 -9999.0 0.0 13.0 SMO/beta Arrestin2 0.048 0.107 0.242 1.0 -0.405 4.0 5.0 SMO 0.002 0.084 -9999.0 0.0 -0.419 4.0 4.0 AKT1 -0.002 0.094 -9999.0 0.0 -0.395 5.0 5.0 ARRB2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.027 0.03 -9999.0 0.0 -0.325 1.0 1.0 ADRBK1 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.002 0.083 -9999.0 0.0 -0.413 4.0 4.0 STIL 0.019 0.109 0.171 33.0 -0.284 6.0 39.0 DHH N/PTCH2 0.029 0.062 -9999.0 0.0 -0.222 8.0 8.0 DHH N/PTCH1 0.019 0.092 -9999.0 0.0 -0.27 12.0 12.0 PIK3CA 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.021 0.059 -9999.0 0.0 -0.325 4.0 4.0 PTHLH -0.005 0.137 -9999.0 0.0 -0.534 8.0 8.0 determination of left/right symmetry 0.002 0.083 -9999.0 0.0 -0.413 4.0 4.0 PIK3R1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.006 0.137 -9999.0 0.0 -0.53 8.0 8.0 IHH N/Hhip 0.007 0.105 -9999.0 0.0 -0.262 18.0 18.0 DHH N/Hhip 0.006 0.099 -9999.0 0.0 -0.236 20.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.002 0.083 -9999.0 0.0 -0.413 4.0 4.0 pancreas development -0.01 0.118 -9999.0 0.0 -0.325 18.0 18.0 HHAT 0.024 0.041 -9999.0 0.0 -0.325 2.0 2.0 PI3K 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.023 0.06 -9999.0 0.0 -0.325 4.0 4.0 somite specification 0.002 0.083 -9999.0 0.0 -0.413 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.001 0.078 -9999.0 0.0 -0.291 6.0 6.0 SHH Np/Cholesterol/PTCH2 -0.004 0.06 -9999.0 0.0 -0.191 11.0 11.0 SHH Np/Cholesterol/Megalin -0.022 0.082 -9999.0 0.0 -0.182 26.0 26.0 SHH -0.02 0.062 0.068 14.0 -0.231 10.0 24.0 catabolic process 0.008 0.09 -9999.0 0.0 -0.321 9.0 9.0 SMO/Vitamin D3 -0.001 0.094 0.25 1.0 -0.349 6.0 7.0 SHH Np/Cholesterol/Hhip -0.011 0.067 -9999.0 0.0 -0.168 20.0 20.0 LRP2 -0.043 0.149 -9999.0 0.0 -0.325 32.0 32.0 receptor-mediated endocytosis -0.025 0.113 0.242 1.0 -0.361 10.0 11.0 SHH Np/Cholesterol/BOC -0.003 0.053 -9999.0 0.0 -0.178 10.0 10.0 SHH Np/Cholesterol/CDO -0.004 0.055 -9999.0 0.0 -0.178 11.0 11.0 mesenchymal cell differentiation 0.011 0.067 0.167 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 0.044 0.116 0.188 39.0 -0.292 6.0 45.0 IHH N/PTCH2 0.031 0.058 -9999.0 0.0 -0.262 4.0 4.0 CDON 0.023 0.051 -9999.0 0.0 -0.325 3.0 3.0 IHH N/PTCH1 0.018 0.092 -9999.0 0.0 -0.323 9.0 9.0 Megalin/LRPAP1 -0.012 0.116 -9999.0 0.0 -0.231 32.0 32.0 PTCH2 0.019 0.058 -9999.0 0.0 -0.325 4.0 4.0 SHH Np/Cholesterol -0.013 0.048 -9999.0 0.0 -0.171 10.0 10.0 PTCH1 0.008 0.09 -9999.0 0.0 -0.322 9.0 9.0 HHIP -0.01 0.119 -9999.0 0.0 -0.325 18.0 18.0