Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.015 0.079 -9999.0 0.0 -0.189 24.0 24.0 epithelial cell differentiation 0.025 0.086 -9999.0 0.0 -0.171 23.0 23.0 CYFIP2 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.048 0.063 0.405 1.0 -9999.0 0.0 1.0 EGFR -0.057 0.131 -9999.0 0.0 -0.325 28.0 28.0 EPHA2 0.027 0.03 -9999.0 0.0 -0.325 1.0 1.0 MYO6 -0.042 0.064 0.183 3.0 -9999.0 0.0 3.0 CTNNB1 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.028 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.098 0.174 0.253 1.0 -0.412 31.0 32.0 CTNND1 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.04 0.062 0.181 3.0 -0.169 1.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.046 0.071 0.181 3.0 -0.302 2.0 5.0 EGF 0.009 0.086 -9999.0 0.0 -0.325 9.0 9.0 NCKAP1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.033 0.084 0.253 1.0 -0.353 5.0 6.0 cortical microtubule organization 0.025 0.086 -9999.0 0.0 -0.171 23.0 23.0 GO:0000145 -0.041 0.058 0.166 3.0 -0.162 1.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.03 0.089 -9999.0 0.0 -0.172 23.0 23.0 MLLT4 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.058 0.05 -9999.0 0.0 -0.171 21.0 21.0 ARF6 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.066 0.037 -9999.0 0.0 -0.185 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.029 0.054 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.033 0.06 0.167 2.0 -9999.0 0.0 2.0 ARF6/GTP 0.069 0.042 -9999.0 0.0 -0.168 2.0 2.0 CDH1 -0.025 0.13 -9999.0 0.0 -0.325 23.0 23.0 EGFR/EGFR/EGF/EGF -0.04 0.095 -9999.0 0.0 -0.194 36.0 36.0 RhoA/GDP 0.026 0.085 -9999.0 0.0 -0.168 23.0 23.0 actin cytoskeleton organization -0.038 0.064 0.173 2.0 -0.175 21.0 23.0 IGF-1R heterotetramer 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.016 0.071 -9999.0 0.0 -0.325 6.0 6.0 DIAPH1 -0.097 0.241 -9999.0 0.0 -0.549 3.0 3.0 Wnt receptor signaling pathway -0.025 0.086 0.171 23.0 -9999.0 0.0 23.0 RHOA 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.059 0.05 -9999.0 0.0 -0.173 21.0 21.0 CTNNA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.039 0.065 0.174 2.0 -0.178 21.0 23.0 EFNA1 0.027 0.03 -9999.0 0.0 -0.325 1.0 1.0 LPP -0.046 0.06 0.177 2.0 -9999.0 0.0 2.0 Ephrin A1/EPHA2 0.019 0.08 -9999.0 0.0 -0.17 21.0 21.0 SEC6/SEC8 -0.041 0.054 -9999.0 0.0 -0.173 17.0 17.0 MGAT3 -0.047 0.072 0.183 3.0 -0.225 5.0 8.0 HGF/MET -0.016 0.098 -9999.0 0.0 -0.205 23.0 23.0 HGF 0.0 0.085 -9999.0 0.0 -0.325 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.08 -9999.0 0.0 -0.19 24.0 24.0 actin cable formation -0.031 0.066 0.358 1.0 -9999.0 0.0 1.0 KIAA1543 -0.045 0.061 0.175 2.0 -0.293 1.0 3.0 KIFC3 -0.046 0.059 0.215 1.0 -9999.0 0.0 1.0 NCK1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.044 0.062 0.191 2.0 -9999.0 0.0 2.0 NCK1/GIT1 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.025 0.086 -9999.0 0.0 -0.171 23.0 23.0 EXOC4 0.02 0.014 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.045 0.061 0.191 2.0 -9999.0 0.0 2.0 PIP5K1C -0.041 0.062 0.183 3.0 -0.171 1.0 4.0 LIMA1 0.026 0.03 -9999.0 0.0 -0.325 1.0 1.0 ABI1 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.05 0.069 0.433 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.041 0.073 0.238 1.0 -0.277 3.0 4.0 IGF-1R heterotetramer/IGF1 0.013 0.089 -9999.0 0.0 -0.168 27.0 27.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.009 0.104 -9999.0 0.0 -0.325 14.0 14.0 PLEKHA7 -0.046 0.065 0.191 2.0 -0.306 1.0 3.0 mol:GTP 0.064 0.037 -9999.0 0.0 -0.184 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.008 0.118 0.311 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization -0.015 0.079 -9999.0 0.0 -0.189 24.0 24.0 regulation of cell-cell adhesion -0.038 0.064 0.173 2.0 -0.175 21.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.08 -9999.0 0.0 -0.19 24.0 24.0