Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.02 0.043 0.23 15.0 -9999.0 0.0 15.0 IHH -0.019 0.022 0.084 22.0 -9999.0 0.0 22.0 SHH Np/Cholesterol/GAS1 -0.016 0.006 0.0 58.0 -9999.0 0.0 58.0 LRPAP1 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.016 0.006 -9999.0 0.0 0.0 58.0 58.0 SMO/beta Arrestin2 -0.013 0.035 0.155 22.0 -9999.0 0.0 22.0 SMO -0.009 0.037 0.166 22.0 -9999.0 0.0 22.0 AKT1 -0.01 0.052 -9999.0 0.0 -0.211 29.0 29.0 ARRB2 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.009 0.036 0.165 22.0 -9999.0 0.0 22.0 STIL -0.022 0.033 0.141 18.0 -9999.0 0.0 18.0 DHH N/PTCH2 -0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.018 0.022 0.157 8.0 -9999.0 0.0 8.0 PIK3CA -0.014 0.003 0.0 25.0 -9999.0 0.0 25.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.017 0.028 0.225 7.0 -9999.0 0.0 7.0 determination of left/right symmetry -0.009 0.036 0.165 22.0 -9999.0 0.0 22.0 PIK3R1 -0.013 0.004 0.0 36.0 -9999.0 0.0 36.0 skeletal system development -0.017 0.028 0.224 7.0 -9999.0 0.0 7.0 IHH N/Hhip -0.008 0.013 0.054 22.0 -9999.0 0.0 22.0 DHH N/Hhip 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.009 0.036 0.165 22.0 -9999.0 0.0 22.0 pancreas development -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.015 0.005 0.0 60.0 -9999.0 0.0 60.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.004 0.0 58.0 -9999.0 0.0 58.0 somite specification -0.009 0.036 0.165 22.0 -9999.0 0.0 22.0 SHH Np/Cholesterol/PTCH1 -0.025 0.021 0.144 8.0 -9999.0 0.0 8.0 SHH Np/Cholesterol/PTCH2 -0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin -0.018 0.001 0.0 1.0 -9999.0 0.0 1.0 SHH -0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.019 0.035 0.188 15.0 -9999.0 0.0 15.0 SMO/Vitamin D3 -0.023 0.023 0.159 8.0 -9999.0 0.0 8.0 SHH Np/Cholesterol/Hhip -0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 -0.014 0.001 0.0 1.0 -9999.0 0.0 1.0 receptor-mediated endocytosis -0.021 0.033 0.138 22.0 -9999.0 0.0 22.0 SHH Np/Cholesterol/BOC -0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO -0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 -0.025 0.024 0.162 8.0 -9999.0 0.0 8.0 IHH N/PTCH2 -0.017 0.016 0.06 22.0 -9999.0 0.0 22.0 CDON -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.021 0.029 0.215 8.0 -9999.0 0.0 8.0 Megalin/LRPAP1 -0.017 0.001 0.0 1.0 -9999.0 0.0 1.0 PTCH2 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.019 0.035 0.188 15.0 -9999.0 0.0 15.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0