Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.021 0.004 0.0 18.0 -9999.0 0.0 18.0 CYFIP2 -0.008 0.007 0.0 225.0 -9999.0 0.0 225.0 ENAH -0.03 0.036 0.14 15.0 -9999.0 0.0 15.0 EGFR -0.009 0.007 0.0 194.0 -9999.0 0.0 194.0 EPHA2 -0.014 0.002 0.0 13.0 -9999.0 0.0 13.0 MYO6 -0.022 0.02 0.084 18.0 -9999.0 0.0 18.0 CTNNB1 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.012 0.01 0.0 225.0 -9999.0 0.0 225.0 AQP5 -0.018 0.018 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 -0.014 0.002 0.0 10.0 -9999.0 0.0 10.0 mol:PI-4-5-P2 -0.021 0.02 0.084 17.0 -9999.0 0.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.02 0.084 18.0 -9999.0 0.0 18.0 EGF -0.014 0.001 0.0 2.0 -9999.0 0.0 2.0 NCKAP1 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.019 0.017 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization -0.021 0.004 0.0 18.0 -9999.0 0.0 18.0 GO:0000145 -0.02 0.018 0.077 17.0 -9999.0 0.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.021 0.004 0.0 18.0 -9999.0 0.0 18.0 MLLT4 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.037 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.022 0.006 0.0 38.0 -9999.0 0.0 38.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.015 0.017 0.076 10.0 -9999.0 0.0 10.0 PVRL2 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.017 0.018 0.084 11.0 -9999.0 0.0 11.0 ARF6/GTP -0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.014 0.002 0.0 8.0 -9999.0 0.0 8.0 EGFR/EGFR/EGF/EGF -0.018 0.015 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP -0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.024 0.019 0.075 18.0 -9999.0 0.0 18.0 IGF-1R heterotetramer -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.014 0.001 0.0 4.0 -9999.0 0.0 4.0 DIAPH1 -0.179 0.224 -9999.0 0.0 -0.439 222.0 222.0 Wnt receptor signaling pathway 0.021 0.004 -9999.0 0.0 0.0 18.0 18.0 RHOA -0.014 0.001 0.0 2.0 -9999.0 0.0 2.0 RhoA/GTP -0.037 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.025 0.019 0.076 18.0 -9999.0 0.0 18.0 EFNA1 -0.014 0.003 0.0 24.0 -9999.0 0.0 24.0 LPP -0.025 0.017 0.076 12.0 -9999.0 0.0 12.0 Ephrin A1/EPHA2 -0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.022 0.02 0.084 18.0 -9999.0 0.0 18.0 HGF/MET -0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 HGF -0.014 0.001 0.0 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation -0.03 0.042 0.135 11.0 -9999.0 0.0 11.0 KIAA1543 -0.016 0.018 0.079 18.0 -9999.0 0.0 18.0 KIFC3 -0.022 0.02 0.084 18.0 -9999.0 0.0 18.0 NCK1 -0.014 0.002 0.0 11.0 -9999.0 0.0 11.0 EXOC3 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.021 0.018 0.084 12.0 -9999.0 0.0 12.0 NCK1/GIT1 -0.017 0.002 0.0 11.0 -9999.0 0.0 11.0 mol:GDP -0.021 0.004 0.0 18.0 -9999.0 0.0 18.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.022 0.02 0.084 18.0 -9999.0 0.0 18.0 PIP5K1C -0.021 0.02 0.084 17.0 -9999.0 0.0 17.0 LIMA1 -0.002 0.005 0.0 453.0 -9999.0 0.0 453.0 ABI1 -0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.031 0.039 0.154 15.0 -9999.0 0.0 15.0 adherens junction assembly -0.026 0.028 0.079 1.0 -0.139 19.0 20.0 IGF-1R heterotetramer/IGF1 -0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.014 0.002 0.0 10.0 -9999.0 0.0 10.0 PLEKHA7 -0.02 0.004 0.0 18.0 -9999.0 0.0 18.0 mol:GTP -0.022 0.006 0.0 38.0 -9999.0 0.0 38.0 establishment of epithelial cell apical/basal polarity -0.033 0.018 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.024 0.019 0.075 18.0 -9999.0 0.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0