E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.012 0.048 -9999.0 0.0 -0.305 12.0 12.0 KLHL20 0.031 0.089 0.192 60.0 -0.201 12.0 72.0 CYFIP2 -0.016 0.014 0.0 220.0 -9999.0 0.0 220.0 Rac1/GDP -0.015 0.045 0.172 7.0 -0.179 6.0 13.0 ENAH -0.009 0.052 -9999.0 0.0 -0.298 13.0 13.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 0.0 29.0 -9999.0 0.0 29.0 RAP1A -0.018 0.021 0.028 83.0 -9999.0 0.0 83.0 CTNNB1 -0.017 0.022 0.028 89.0 -9999.0 0.0 89.0 CDC42/GTP -0.043 0.04 0.102 25.0 -0.137 3.0 28.0 ABI1/Sra1/Nap1 -0.013 0.024 -9999.0 0.0 -0.129 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.064 0.027 -9999.0 0.0 -0.046 22.0 22.0 RAPGEF1 -0.016 0.06 0.164 11.0 -0.289 10.0 21.0 CTNND1 -0.018 0.021 0.028 84.0 -9999.0 0.0 84.0 regulation of calcium-dependent cell-cell adhesion 0.013 0.054 -9999.0 0.0 -0.303 13.0 13.0 CRK -0.012 0.06 0.159 26.0 -0.296 12.0 38.0 E-cadherin/gamma catenin/alpha catenin 0.052 0.018 -9999.0 0.0 -0.039 16.0 16.0 alphaE/beta7 Integrin 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 -0.021 0.012 0.0 128.0 -9999.0 0.0 128.0 NCKAP1 -0.028 0.002 0.0 2.0 -9999.0 0.0 2.0 Rap1/GTP/I-afadin 0.03 0.017 -9999.0 0.0 -0.022 44.0 44.0 DLG1 -0.013 0.05 -9999.0 0.0 -0.303 13.0 13.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.041 0.024 -9999.0 0.0 -0.106 5.0 5.0 MLLT4 -0.021 0.017 0.014 83.0 -9999.0 0.0 83.0 ARF6/GTP/NME1/Tiam1 0.031 0.014 -9999.0 0.0 -0.021 26.0 26.0 PI3K -0.051 0.03 -9999.0 0.0 -0.132 5.0 5.0 ARF6 -0.018 0.021 0.028 81.0 -9999.0 0.0 81.0 mol:Ca2+ 0.0 0.0 0.001 93.0 -9999.0 0.0 93.0 E-cadherin/gamma catenin 0.038 0.01 -9999.0 0.0 0.0 35.0 35.0 TIAM1 -0.017 0.021 0.028 81.0 -9999.0 0.0 81.0 E-cadherin(dimer)/Ca2+ 0.06 0.024 -9999.0 0.0 -0.041 22.0 22.0 AKT1 -0.028 0.042 0.136 11.0 -0.111 1.0 12.0 PIK3R1 -0.025 0.009 0.001 47.0 -9999.0 0.0 47.0 CDH1 -0.017 0.021 0.028 87.0 -9999.0 0.0 87.0 RhoA/GDP -0.021 0.062 0.189 11.0 -0.204 3.0 14.0 actin cytoskeleton organization 0.027 0.071 0.138 92.0 -0.148 12.0 104.0 CDC42/GDP -0.022 0.06 0.191 10.0 -0.185 9.0 19.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.005 0.023 -9999.0 0.0 -0.107 19.0 19.0 ITGB7 -0.027 0.004 0.0 11.0 -9999.0 0.0 11.0 RAC1 -0.012 0.02 0.028 70.0 -9999.0 0.0 70.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.065 0.026 -9999.0 0.0 -0.045 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.046 0.017 -9999.0 0.0 -0.031 19.0 19.0 mol:GDP -0.017 0.063 0.213 9.0 -0.201 9.0 18.0 CDC42/GTP/IQGAP1 0.027 0.017 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.027 0.006 0.0 22.0 -9999.0 0.0 22.0 p120 catenin/RhoA/GDP -0.019 0.067 0.168 32.0 -0.192 9.0 41.0 RAC1/GTP/IQGAP1 0.019 0.019 -9999.0 0.0 0.0 247.0 247.0 PIP5K1C/AP1M1 0.019 0.005 -9999.0 0.0 0.0 38.0 38.0 RHOA -0.027 0.005 0.0 15.0 -9999.0 0.0 15.0 CDC42 -0.027 0.005 0.0 18.0 -9999.0 0.0 18.0 CTNNA1 -0.018 0.021 0.028 88.0 -9999.0 0.0 88.0 positive regulation of S phase of mitotic cell cycle 0.004 0.035 0.093 26.0 -0.099 12.0 38.0 NME1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.012 0.05 -9999.0 0.0 -0.303 13.0 13.0 regulation of cell-cell adhesion -0.043 0.022 -9999.0 0.0 -0.106 9.0 9.0 WASF2 -0.007 0.013 -9999.0 0.0 -0.069 14.0 14.0 Rap1/GTP -0.036 0.047 0.128 30.0 -0.176 1.0 31.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.074 0.03 -9999.0 0.0 -0.053 20.0 20.0 CCND1 0.004 0.042 0.107 26.0 -0.119 12.0 38.0 VAV2 0.001 0.121 -9999.0 0.0 -0.569 16.0 16.0 RAP1/GDP -0.026 0.053 0.145 32.0 -0.193 1.0 33.0 adherens junction assembly -0.012 0.049 -9999.0 0.0 -0.295 13.0 13.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 -0.022 0.012 0.0 115.0 -9999.0 0.0 115.0 PIP5K1C -0.026 0.007 0.0 38.0 -9999.0 0.0 38.0 regulation of heterotypic cell-cell adhesion -0.052 0.035 0.119 17.0 -9999.0 0.0 17.0 E-cadherin/beta catenin -0.007 0.023 -9999.0 0.0 -0.128 8.0 8.0 mol:GTP 0.0 0.0 0.001 89.0 -9999.0 0.0 89.0 SRC -0.012 0.049 -9999.0 0.0 -0.304 12.0 12.0 PIK3CA -0.026 0.008 0.001 37.0 -9999.0 0.0 37.0 Rac1/GTP -0.021 0.054 0.13 7.0 -0.309 12.0 19.0 E-cadherin/beta catenin/alpha catenin 0.052 0.019 -9999.0 0.0 -0.039 18.0 18.0 ITGAE -0.027 0.004 0.0 12.0 -9999.0 0.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.013 0.055 -9999.0 0.0 -0.308 13.0 13.0