Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.042 0.016 -9999.0 0.0 -0.091 19.0 19.0 KIRREL -0.023 0.027 0.053 20.0 -9999.0 0.0 20.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.042 0.016 0.091 19.0 -9999.0 0.0 19.0 PLCG1 -0.026 0.008 0.0 40.0 -9999.0 0.0 40.0 ARRB2 -0.027 0.004 0.0 10.0 -9999.0 0.0 10.0 WASL -0.019 0.013 0.0 157.0 -9999.0 0.0 157.0 Nephrin/NEPH1/podocin/CD2AP 0.068 0.033 0.161 19.0 -0.047 12.0 31.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.008 0.019 0.078 7.0 -0.131 4.0 11.0 FYN -0.021 0.046 0.156 28.0 -9999.0 0.0 28.0 mol:Ca2+ 0.063 0.033 0.153 19.0 -0.051 5.0 24.0 mol:DAG 0.064 0.033 0.156 19.0 -0.051 5.0 24.0 NPHS2 -0.022 0.028 0.049 42.0 -9999.0 0.0 42.0 mol:IP3 0.064 0.033 0.156 19.0 -0.051 5.0 24.0 regulation of endocytosis 0.044 0.025 0.127 1.0 -0.053 8.0 9.0 Nephrin/NEPH1/podocin/Cholesterol 0.053 0.027 0.141 19.0 -0.042 4.0 23.0 establishment of cell polarity 0.042 0.016 0.091 19.0 -9999.0 0.0 19.0 Nephrin/NEPH1/podocin/NCK1-2 0.078 0.037 0.169 18.0 -0.056 8.0 26.0 Nephrin/NEPH1/beta Arrestin2 0.046 0.026 0.132 1.0 -0.054 8.0 9.0 NPHS1 -0.023 0.026 0.056 28.0 -9999.0 0.0 28.0 Nephrin/NEPH1/podocin 0.049 0.02 0.159 3.0 -0.059 4.0 7.0 TJP1 -0.027 0.005 0.0 16.0 -9999.0 0.0 16.0 NCK1 -0.027 0.006 0.0 25.0 -9999.0 0.0 25.0 NCK2 -0.028 0.003 0.0 7.0 -9999.0 0.0 7.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.066 0.034 0.159 19.0 -0.051 5.0 24.0 CD2AP -0.025 0.009 0.0 58.0 -9999.0 0.0 58.0 Nephrin/NEPH1/podocin/GRB2 0.067 0.031 0.16 16.0 -0.055 4.0 20.0 GRB2 -0.027 0.005 0.0 16.0 -9999.0 0.0 16.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.026 0.052 0.163 30.0 -9999.0 0.0 30.0 cytoskeleton organization -0.02 0.036 0.175 9.0 -0.162 3.0 12.0 Nephrin/NEPH1 0.035 0.014 0.076 19.0 -0.028 4.0 23.0 Nephrin/NEPH1/ZO-1 0.052 0.024 0.114 3.0 -0.043 13.0 16.0