Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.026 0.038 0.147 21.0 -9999.0 0.0 21.0 IHH -0.027 0.034 0.09 37.0 -9999.0 0.0 37.0 SHH Np/Cholesterol/GAS1 -0.021 0.017 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 -0.028 0.002 0.0 4.0 -9999.0 0.0 4.0 dorsoventral neural tube patterning 0.021 0.017 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 0.028 0.072 0.226 4.0 -9999.0 0.0 4.0 SMO -0.004 0.025 0.13 4.0 -0.159 2.0 6.0 AKT1 -0.006 0.076 -9999.0 0.0 -0.359 14.0 14.0 ARRB2 -0.027 0.004 0.0 10.0 -9999.0 0.0 10.0 BOC -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 -0.028 0.003 0.0 7.0 -9999.0 0.0 7.0 heart looping -0.004 0.025 0.129 4.0 -9999.0 0.0 4.0 STIL 0.012 0.087 0.153 129.0 -9999.0 0.0 129.0 DHH N/PTCH2 0.02 0.003 -9999.0 0.0 0.0 10.0 10.0 DHH N/PTCH1 -0.02 0.021 0.099 15.0 -9999.0 0.0 15.0 PIK3CA -0.026 0.007 0.0 36.0 -9999.0 0.0 36.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.012 0.039 0.152 25.0 -9999.0 0.0 25.0 determination of left/right symmetry -0.004 0.025 0.129 4.0 -9999.0 0.0 4.0 PIK3R1 -0.026 0.008 0.0 45.0 -9999.0 0.0 45.0 skeletal system development -0.012 0.039 0.152 25.0 -9999.0 0.0 25.0 IHH N/Hhip 0.022 0.011 0.067 22.0 -9999.0 0.0 22.0 DHH N/Hhip 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.004 0.025 0.129 4.0 -9999.0 0.0 4.0 pancreas development -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT -0.027 0.005 0.0 16.0 -9999.0 0.0 16.0 PI3K 0.035 0.015 -9999.0 0.0 0.0 78.0 78.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.024 0.01 0.0 69.0 -9999.0 0.0 69.0 somite specification -0.004 0.025 0.129 4.0 -9999.0 0.0 4.0 SHH Np/Cholesterol/PTCH1 -0.025 0.025 0.09 10.0 -9999.0 0.0 10.0 SHH Np/Cholesterol/PTCH2 -0.023 0.017 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin -0.024 0.017 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.022 0.016 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.023 0.026 0.12 15.0 -9999.0 0.0 15.0 SMO/Vitamin D3 -0.018 0.037 0.156 13.0 -9999.0 0.0 13.0 SHH Np/Cholesterol/Hhip -0.016 0.011 0.0 165.0 -9999.0 0.0 165.0 LRP2 -0.028 0.002 0.0 3.0 -9999.0 0.0 3.0 receptor-mediated endocytosis -0.017 0.035 0.128 12.0 -9999.0 0.0 12.0 SHH Np/Cholesterol/BOC -0.016 0.011 0.0 165.0 -9999.0 0.0 165.0 SHH Np/Cholesterol/CDO -0.024 0.017 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.016 0.011 -9999.0 0.0 0.0 165.0 165.0 mol:Vitamin D3 0.027 0.099 0.175 149.0 -9999.0 0.0 149.0 IHH N/PTCH2 0.042 0.012 0.101 10.0 -9999.0 0.0 10.0 CDON -0.028 0.003 0.0 7.0 -9999.0 0.0 7.0 IHH N/PTCH1 -0.023 0.027 0.125 15.0 -9999.0 0.0 15.0 Megalin/LRPAP1 0.04 0.005 -9999.0 0.0 0.0 7.0 7.0 PTCH2 -0.027 0.004 0.0 10.0 -9999.0 0.0 10.0 SHH Np/Cholesterol -0.016 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.023 0.026 0.12 15.0 -9999.0 0.0 15.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0