Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Glypican 2 network	226.0	906.0	4.0	-0.011	0.008	1000.0	-1000.0	-0.025	-1000.0
FOXM1 transcription factor network	192.0	9836.0	51.0	-0.028	0.418	1000.0	-1000.0	-0.16	-1000.0
Endothelins	126.0	12098.0	96.0	-0.436	0.125	1000.0	-1000.0	-0.046	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	118.0	8024.0	68.0	-0.391	0.246	1000.0	-1000.0	-0.06	-1000.0
HIF-1-alpha transcription factor network	116.0	8837.0	76.0	-0.03	0.288	1000.0	-1000.0	-0.056	-1000.0
Effects of Botulinum toxin	91.0	2376.0	26.0	-0.028	0.045	1000.0	-1000.0	-0.026	-1000.0
Osteopontin-mediated events	90.0	3455.0	38.0	-0.028	0.069	1000.0	-1000.0	-0.026	-1000.0
Ras signaling in the CD4+ TCR pathway	84.0	1433.0	17.0	-0.014	0.052	1000.0	-1000.0	-0.025	-1000.0
Arf6 signaling events	81.0	5035.0	62.0	-0.028	0.068	1000.0	-1000.0	-0.026	-1000.0
S1P5 pathway	80.0	1362.0	17.0	-0.05	0.049	1000.0	-1000.0	-0.026	-1000.0
HIF-2-alpha transcription factor network	80.0	3478.0	43.0	-0.057	0.074	1000.0	-1000.0	-0.037	-1000.0
LPA receptor mediated events	75.0	7660.0	102.0	-0.027	0.079	1000.0	-1000.0	-0.058	-1000.0
TCGA08_rtk_signaling	73.0	1916.0	26.0	-0.034	0.119	1000.0	-1000.0	-0.026	-1000.0
TCGA08_p53	72.0	510.0	7.0	-0.025	0.005	1000.0	-1000.0	-0.025	-1000.0
Syndecan-1-mediated signaling events	70.0	2393.0	34.0	-0.028	0.056	1000.0	-1000.0	-0.026	-1000.0
S1P4 pathway	68.0	1711.0	25.0	-0.049	0.032	1000.0	-1000.0	-0.025	-1000.0
Alternative NF-kappaB pathway	64.0	833.0	13.0	-0.028	0.046	1000.0	-1000.0	-0.026	-1000.0
Signaling events regulated by Ret tyrosine kinase	63.0	5198.0	82.0	-0.069	0.04	1000.0	-1000.0	-0.032	-1000.0
FoxO family signaling	63.0	4059.0	64.0	-0.058	0.094	1000.0	-1000.0	-0.064	-1000.0
IL6-mediated signaling events	63.0	4780.0	75.0	-0.027	0.215	1000.0	-1000.0	-0.079	-1000.0
Ceramide signaling pathway	61.0	4656.0	76.0	-0.095	0.056	1000.0	-1000.0	-0.026	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	61.0	2029.0	33.0	-0.069	0.053	1000.0	-1000.0	-0.026	-1000.0
Nongenotropic Androgen signaling	60.0	3126.0	52.0	-0.093	0.052	1000.0	-1000.0	-0.026	-1000.0
PLK2 and PLK4 events	53.0	161.0	3.0	-0.027	-0.023	1000.0	-1000.0	-0.026	-1000.0
a4b1 and a4b7 Integrin signaling	52.0	262.0	5.0	-0.028	0.039	1000.0	-1000.0	-0.026	-1000.0
IL2 signaling events mediated by PI3K	52.0	3041.0	58.0	-0.175	0.039	1000.0	-1000.0	-0.036	-1000.0
Sphingosine 1-phosphate (S1P) pathway	51.0	1438.0	28.0	-0.027	0.028	1000.0	-1000.0	-0.026	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	51.0	1915.0	37.0	-0.037	0.063	1000.0	-1000.0	-0.026	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	50.0	2642.0	52.0	-0.028	0.13	1000.0	-1000.0	-0.028	-1000.0
Wnt signaling	49.0	343.0	7.0	-0.028	0.022	1000.0	-1000.0	-0.025	-1000.0
Presenilin action in Notch and Wnt signaling	48.0	2976.0	61.0	-0.029	0.069	1000.0	-1000.0	-0.034	-1000.0
Thromboxane A2 receptor signaling	47.0	4960.0	105.0	-0.052	0.107	1000.0	-1000.0	-0.048	-1000.0
Syndecan-4-mediated signaling events	47.0	3159.0	67.0	-0.029	0.032	1000.0	-1000.0	-0.032	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	46.0	5563.0	120.0	-0.051	0.069	1000.0	-1000.0	-0.034	-1000.0
BARD1 signaling events	45.0	2614.0	57.0	-0.06	0.069	1000.0	-1000.0	-0.047	-1000.0
BMP receptor signaling	44.0	3608.0	81.0	-0.04	0.049	1000.0	-1000.0	-0.029	-1000.0
Regulation of p38-alpha and p38-beta	44.0	2417.0	54.0	-0.028	0.035	1000.0	-1000.0	-0.033	-1000.0
PLK1 signaling events	43.0	3694.0	85.0	-0.028	0.054	1000.0	-1000.0	-0.026	-1000.0
amb2 Integrin signaling	43.0	3528.0	82.0	-0.028	0.074	1000.0	-1000.0	-0.027	-1000.0
Plasma membrane estrogen receptor signaling	43.0	3716.0	86.0	-0.451	0.07	1000.0	-1000.0	-0.038	-1000.0
JNK signaling in the CD4+ TCR pathway	42.0	716.0	17.0	-0.124	0.054	1000.0	-1000.0	-0.026	-1000.0
Reelin signaling pathway	42.0	2383.0	56.0	-0.042	0.049	1000.0	-1000.0	-0.035	-1000.0
Paxillin-dependent events mediated by a4b1	42.0	1526.0	36.0	-0.052	0.047	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	42.0	1894.0	45.0	-0.061	0.053	1000.0	-1000.0	-0.03	-1000.0
p38 MAPK signaling pathway	42.0	1881.0	44.0	-0.028	0.054	1000.0	-1000.0	-0.026	-1000.0
Integrins in angiogenesis	41.0	3453.0	84.0	-0.048	0.068	1000.0	-1000.0	-0.038	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	40.0	3443.0	85.0	-0.044	0.115	1000.0	-1000.0	-0.034	-1000.0
p75(NTR)-mediated signaling	40.0	5124.0	125.0	-0.063	0.068	1000.0	-1000.0	-0.038	-1000.0
Nectin adhesion pathway	40.0	2557.0	63.0	-0.028	0.061	1000.0	-1000.0	-0.034	-1000.0
EGFR-dependent Endothelin signaling events	40.0	850.0	21.0	-0.028	0.027	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Cones	39.0	1518.0	38.0	-0.028	0.044	1000.0	-1000.0	-0.026	-1000.0
Syndecan-3-mediated signaling events	39.0	1397.0	35.0	-0.028	0.068	1000.0	-1000.0	-0.026	-1000.0
Regulation of nuclear SMAD2/3 signaling	38.0	5180.0	136.0	-0.217	0.088	1000.0	-1000.0	-0.034	-1000.0
E-cadherin signaling in the nascent adherens junction	38.0	2898.0	76.0	-0.052	0.074	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	38.0	3016.0	78.0	-0.062	0.034	1000.0	-1000.0	-0.049	-1000.0
Glypican 1 network	37.0	1802.0	48.0	-0.038	0.052	1000.0	-1000.0	-0.027	-1000.0
FAS signaling pathway (CD95)	37.0	1771.0	47.0	-0.133	0.035	1000.0	-1000.0	-0.037	-1000.0
EPHB forward signaling	37.0	3177.0	85.0	-0.063	0.067	1000.0	-1000.0	-0.043	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	35.0	1906.0	54.0	-0.036	0.039	1000.0	-1000.0	-0.027	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	35.0	2643.0	74.0	-0.237	0.065	1000.0	-1000.0	-0.044	-1000.0
EPO signaling pathway	34.0	1887.0	55.0	-0.029	0.039	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	34.0	2339.0	68.0	-0.103	0.057	1000.0	-1000.0	-0.035	-1000.0
IL1-mediated signaling events	34.0	2157.0	62.0	-0.06	0.071	1000.0	-1000.0	-0.035	-1000.0
Signaling mediated by p38-alpha and p38-beta	34.0	1505.0	44.0	-0.042	0.056	1000.0	-1000.0	-0.026	-1000.0
Angiopoietin receptor Tie2-mediated signaling	33.0	2904.0	88.0	-0.03	0.109	1000.0	-1000.0	-0.054	-1000.0
Insulin-mediated glucose transport	32.0	1037.0	32.0	-0.044	0.036	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class III	32.0	1310.0	40.0	-0.028	0.025	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	32.0	4109.0	125.0	-0.034	0.048	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling in keratinocytes	32.0	1377.0	43.0	-0.027	0.053	1000.0	-1000.0	-0.026	-1000.0
Circadian rhythm pathway	31.0	687.0	22.0	-0.027	0.061	1000.0	-1000.0	-0.025	-1000.0
Retinoic acid receptors-mediated signaling	30.0	1786.0	58.0	-0.055	0.05	1000.0	-1000.0	-0.03	-1000.0
Class I PI3K signaling events	30.0	2246.0	73.0	-0.028	0.047	1000.0	-1000.0	-0.027	-1000.0
Arf6 trafficking events	30.0	2173.0	71.0	-0.03	0.035	1000.0	-1000.0	-0.027	-1000.0
Regulation of Telomerase	30.0	3110.0	102.0	-0.034	0.064	1000.0	-1000.0	-0.043	-1000.0
Noncanonical Wnt signaling pathway	29.0	769.0	26.0	-0.028	0.032	1000.0	-1000.0	-0.026	-1000.0
Aurora A signaling	29.0	1741.0	60.0	-0.028	0.051	1000.0	-1000.0	-0.026	-1000.0
Canonical Wnt signaling pathway	29.0	1490.0	51.0	-0.047	0.089	1000.0	-1000.0	-0.03	-1000.0
Caspase cascade in apoptosis	28.0	2137.0	74.0	-0.06	0.056	1000.0	-1000.0	-0.028	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	28.0	658.0	23.0	-0.028	0.052	1000.0	-1000.0	-0.026	-1000.0
Syndecan-2-mediated signaling events	28.0	1991.0	69.0	-0.041	0.043	1000.0	-1000.0	-0.035	-1000.0
Arf6 downstream pathway	28.0	1227.0	43.0	-0.028	0.047	1000.0	-1000.0	-0.026	-1000.0
IL2 signaling events mediated by STAT5	28.0	618.0	22.0	-0.029	0.037	1000.0	-1000.0	-0.029	-1000.0
VEGFR1 specific signals	28.0	1569.0	56.0	-0.05	0.047	1000.0	-1000.0	-0.028	-1000.0
Aurora B signaling	28.0	1884.0	67.0	-0.028	0.066	1000.0	-1000.0	-0.026	-1000.0
mTOR signaling pathway	27.0	1471.0	53.0	-0.033	0.045	1000.0	-1000.0	-0.028	-1000.0
Class I PI3K signaling events mediated by Akt	27.0	1863.0	68.0	-0.044	0.05	1000.0	-1000.0	-0.027	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	27.0	2248.0	83.0	-0.064	0.052	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class I	27.0	2889.0	104.0	-0.035	0.061	1000.0	-1000.0	-0.03	-1000.0
PDGFR-alpha signaling pathway	26.0	1184.0	44.0	-0.033	0.045	1000.0	-1000.0	-0.026	-1000.0
BCR signaling pathway	26.0	2623.0	99.0	-0.041	0.071	1000.0	-1000.0	-0.043	-1000.0
IL12-mediated signaling events	25.0	2235.0	87.0	-0.093	0.044	1000.0	-1000.0	-0.076	-1000.0
Signaling events mediated by the Hedgehog family	25.0	1350.0	52.0	-0.028	0.042	1000.0	-1000.0	-0.027	-1000.0
TRAIL signaling pathway	25.0	1231.0	48.0	-0.058	0.072	1000.0	-1000.0	-0.026	-1000.0
PDGFR-beta signaling pathway	25.0	2425.0	97.0	-0.055	0.105	1000.0	-1000.0	-0.038	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	24.0	817.0	34.0	-0.042	0.078	1000.0	-1000.0	-0.036	-1000.0
Ephrin B reverse signaling	24.0	1189.0	48.0	-0.028	0.046	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by PRL	24.0	840.0	34.0	-0.027	0.039	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	23.0	1754.0	75.0	-0.037	0.064	1000.0	-1000.0	-0.028	-1000.0
IL23-mediated signaling events	23.0	1380.0	60.0	-0.028	0.105	1000.0	-1000.0	-0.104	-1000.0
Signaling events mediated by PTP1B	22.0	1687.0	76.0	-0.028	0.065	1000.0	-1000.0	-0.026	-1000.0
TCGA08_retinoblastoma	22.0	179.0	8.0	-0.017	0.033	1000.0	-1000.0	-0.003	-1000.0
ErbB2/ErbB3 signaling events	21.0	1386.0	65.0	-0.051	0.038	1000.0	-1000.0	-0.05	-1000.0
Canonical NF-kappaB pathway	21.0	820.0	39.0	-0.046	0.052	1000.0	-1000.0	-0.026	-1000.0
TCR signaling in naïve CD8+ T cells	21.0	1969.0	93.0	-0.327	0.372	1000.0	-1000.0	-0.037	-1000.0
Insulin Pathway	21.0	1554.0	74.0	-0.05	0.073	1000.0	-1000.0	-0.033	-1000.0
S1P3 pathway	20.0	875.0	42.0	-0.05	0.028	1000.0	-1000.0	-0.026	-1000.0
Arf1 pathway	20.0	1119.0	54.0	-0.064	0.035	1000.0	-1000.0	-0.026	-1000.0
Fc-epsilon receptor I signaling in mast cells	19.0	1882.0	97.0	-0.1	0.056	1000.0	-1000.0	-0.054	-1000.0
ceramide signaling pathway	18.0	889.0	49.0	-0.028	0.053	1000.0	-1000.0	-0.029	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	18.0	502.0	27.0	-0.043	0.059	1000.0	-1000.0	-0.029	-1000.0
Signaling mediated by p38-gamma and p38-delta	17.0	264.0	15.0	-0.038	0.0	1000.0	-1000.0	-0.026	-1000.0
Atypical NF-kappaB pathway	17.0	548.0	31.0	-0.038	0.035	1000.0	-1000.0	-0.028	-1000.0
ErbB4 signaling events	16.0	1120.0	69.0	-0.051	0.048	1000.0	-1000.0	-0.03	-1000.0
S1P1 pathway	16.0	602.0	36.0	-0.051	0.046	1000.0	-1000.0	-0.028	-1000.0
Rapid glucocorticoid signaling	16.0	322.0	20.0	-0.027	0.017	1000.0	-1000.0	-0.025	-1000.0
Hedgehog signaling events mediated by Gli proteins	15.0	1016.0	65.0	-0.031	0.044	1000.0	-1000.0	-0.026	-1000.0
Aurora C signaling	15.0	108.0	7.0	-0.027	0.046	1000.0	-1000.0	-0.026	-1000.0
Glucocorticoid receptor regulatory network	15.0	1808.0	114.0	-0.088	0.119	1000.0	-1000.0	-0.049	-1000.0
IGF1 pathway	15.0	859.0	57.0	-0.057	0.06	1000.0	-1000.0	-0.032	-1000.0
Visual signal transduction: Rods	15.0	787.0	52.0	-0.057	0.062	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling events	14.0	71.0	5.0	-0.027	0.051	1000.0	-1000.0	-0.025	-1000.0
Cellular roles of Anthrax toxin	12.0	479.0	39.0	-0.032	0.026	1000.0	-1000.0	-0.025	-1000.0
IL4-mediated signaling events	12.0	1149.0	91.0	-0.124	0.063	1000.0	-1000.0	-0.175	-1000.0
Ephrin A  reverse signaling	11.0	82.0	7.0	-0.03	0.036	1000.0	-1000.0	-0.026	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.027	-1000.0	1000.0	-1000.0	-0.025	-1000.0
Regulation of Androgen receptor activity	9.0	674.0	70.0	-0.059	0.049	1000.0	-1000.0	-0.031	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	219.0	31.0	-0.07	0.019	1000.0	-1000.0	-0.025	-1000.0
IL27-mediated signaling events	7.0	399.0	51.0	-0.054	0.048	1000.0	-1000.0	-0.035	-1000.0
Coregulation of Androgen receptor activity	6.0	485.0	76.0	-0.031	0.049	1000.0	-1000.0	-0.027	-1000.0
FOXA2 and FOXA3 transcription factor networks	5.0	239.0	46.0	-0.029	0.029	1000.0	-1000.0	-0.09	-1000.0
LPA4-mediated signaling events	4.0	50.0	12.0	-0.026	0.0	1000.0	-1000.0	-0.019	-1000.0
Total	5256	283269	7203	-7.61830967682	-991.725713968	131000	-131000	-4.62141563108	-131000