Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.048 0.02 0.022 1.0 -0.104 19.0 20.0 KIRREL 0.036 0.012 0.086 1.0 -0.041 5.0 6.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.049 0.02 0.104 19.0 -0.022 1.0 20.0 PLCG1 0.029 0.011 -9999.0 0.0 0.0 66.0 66.0 ARRB2 0.032 0.005 -9999.0 0.0 0.0 13.0 13.0 WASL 0.019 0.016 -9999.0 0.0 0.0 211.0 211.0 Nephrin/NEPH1/podocin/CD2AP 0.073 0.039 0.18 7.0 -9999.0 0.0 7.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.014 0.028 0.108 25.0 -0.132 5.0 30.0 FYN -0.014 0.057 0.161 44.0 -9999.0 0.0 44.0 mol:Ca2+ 0.069 0.042 0.171 18.0 -0.061 5.0 23.0 mol:DAG 0.071 0.043 0.175 18.0 -0.061 5.0 23.0 NPHS2 0.036 0.012 0.086 1.0 -0.041 5.0 6.0 mol:IP3 0.071 0.043 0.175 18.0 -0.061 5.0 23.0 regulation of endocytosis 0.052 0.034 0.141 2.0 -0.072 5.0 7.0 Nephrin/NEPH1/podocin/Cholesterol 0.061 0.032 0.156 19.0 -0.049 5.0 24.0 establishment of cell polarity 0.048 0.02 0.104 19.0 -0.022 1.0 20.0 Nephrin/NEPH1/podocin/NCK1-2 0.09 0.044 0.189 10.0 -9999.0 0.0 10.0 Nephrin/NEPH1/beta Arrestin2 0.054 0.035 0.147 2.0 -0.072 5.0 7.0 NPHS1 0.034 0.013 0.077 7.0 -9999.0 0.0 7.0 Nephrin/NEPH1/podocin 0.057 0.026 0.167 4.0 -0.066 5.0 9.0 TJP1 0.032 0.006 -9999.0 0.0 0.0 19.0 19.0 NCK1 0.031 0.008 -9999.0 0.0 0.0 28.0 28.0 NCK2 0.033 0.004 -9999.0 0.0 0.0 7.0 7.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.072 0.044 0.178 18.0 -0.061 5.0 23.0 CD2AP 0.03 0.011 -9999.0 0.0 0.0 58.0 58.0 Nephrin/NEPH1/podocin/GRB2 0.076 0.04 0.18 16.0 -9999.0 0.0 16.0 GRB2 0.032 0.007 -9999.0 0.0 0.0 22.0 22.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.019 0.063 0.167 46.0 -9999.0 0.0 46.0 cytoskeleton organization -0.006 0.055 0.148 40.0 -0.165 4.0 44.0 Nephrin/NEPH1 0.041 0.018 0.098 4.0 -0.034 5.0 9.0 Nephrin/NEPH1/ZO-1 0.06 0.032 -9999.0 0.0 -0.051 16.0 16.0