Clinical Features	Time to Death		YEARS_TO_BIRTH		PATHOLOGIC_STAGE		PATHOLOGY_T_STAGE		PATHOLOGY_N_STAGE		GENDER		RADIATION_THERAPY		HISTOLOGICAL_TYPE		NUMBER_PACK_YEARS_SMOKED		YEAR_OF_TOBACCO_SMOKING_ONSET		NUMBER_OF_LYMPH_NODES		RACE		ETHNICITY	
	nMutated (%)	nWild-Type	logrank test_P	logrank test_Q	Wilcoxon-test_P	Wilcoxon-test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Wilcoxon-test_P	Wilcoxon-test_Q	Wilcoxon-test_P	Wilcoxon-test_Q	Wilcoxon-test_P	Wilcoxon-test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	359 (70%)	151	0.0021434	0.187	0.3139	1	0.42786	1	0.02557	0.562	0.65011	1	0.82807	1	0.50309	1	0.00351	0.19	0.0355	0.62	0.9567	1	0.65288	1	0.55128	1	0.12279	0.866
CDKN2A	112 (22%)	398	0.8184	1	0.13377	0.883	0.15203	0.883	0.83451	1	0.50548	1	1	1	0.53664	1	0.49836	1	0.37245	1	0.56639	1	0.44853	1	0.75479	1	0.63134	1
CASP8	55 (11%)	455	0.051747	0.701	3.3423e-09	2.13e-06	0.80776	1	0.38077	1	0.071519	0.759	0.00033608	0.0535	0.25664	1	1	1	0.085729	0.773	0.014553	0.386	0.018563	0.455	0.72163	1	0.51667	1
NSD1	63 (12%)	447	0.059293	0.726	0.038919	0.62	0.10161	0.809	0.51764	1	0.03682	0.62	0.069716	0.758	0.87939	1	1	1	0.15816	0.883	0.54937	1	0.00030649	0.0535	0.68057	1	0.34877	1
HLA-B	24 (5%)	486	0.89873	1	0.19474	0.932	0.75286	1	0.3423	1	0.03803	0.62	0.15673	0.883	0.16603	0.889	0.32108	1	0.20478	0.938	0.14391	0.883	0.30278	1	0.51375	1	0.61415	1
MLL2	78 (15%)	432	0.066051	0.758	0.35566	1	0.39869	1	0.20048	0.937	0.93506	1	0.89067	1	0.88682	1	0.66317	1	0.3541	1	0.93308	1	0.82805	1	0.15839	0.883	0.4017	1
TGFBR2	23 (5%)	487	0.73211	1	0.058235	0.726	0.90972	1	0.72723	1	0.54956	1	1	1	0.34224	1	1	1	0.3856	1	0.09106	0.773	0.40844	1	0.58993	1	1	1
FAT1	114 (22%)	396	0.63421	1	8.5256e-07	0.000272	0.75517	1	0.03781	0.62	0.32465	1	0.012513	0.362	1	1	1	1	0.15026	0.883	0.016761	0.427	0.35829	1	0.60394	1	0.47151	1
NOTCH1	87 (17%)	423	0.2212	0.957	0.0056506	0.234	0.88349	1	0.45804	1	0.46081	1	0.065571	0.758	0.035973	0.62	0.67731	1	0.080187	0.773	0.25236	1	0.20411	0.938	0.86158	1	0.19537	0.932
JUB	33 (6%)	477	0.055146	0.716	0.0058846	0.234	0.64226	1	0.64555	1	0.24844	1	1	1	0.54308	1	1	1	0.26372	1	0.003876	0.19	0.49064	1	0.19339	0.932	0.67588	1
NFE2L2	26 (5%)	484	0.38688	1	0.003865	0.19	0.647	1	0.85124	1	0.59247	1	0.11157	0.846	0.075681	0.773	1	1	0.64811	1	0.46313	1	0.34245	1	0.32065	1	0.34317	1
FBXW7	33 (6%)	477	0.29396	1	0.0065538	0.246	0.77366	1	0.39863	1	0.3456	1	0.15588	0.883	0.4274	1	1	1	0.36654	1	0.89439	1	0.18692	0.932	0.88156	1	0.66804	1
ZNF750	19 (4%)	491	0.92682	1	0.37112	1	0.28071	1	0.71104	1	0.53823	1	0.30425	1	1	1	1	1	0.52384	1	0.50988	1	0.070249	0.758	0.4072	1	0.61505	1
RAC1	15 (3%)	495	0.45822	1	0.0011669	0.124	0.1959	0.932	0.18462	0.932	0.38043	1	0.0073666	0.261	1	1	1	1	0.66981	1	0.0049307	0.224	0.18882	0.932	0.31047	1	1	1
EPHA2	24 (5%)	486	0.24741	1	0.085104	0.773	0.88481	1	0.64788	1	0.49141	1	0.48959	1	0.34224	1	1	1	0.044327	0.627	0.16359	0.883	0.95533	1	0.50057	1	1	1
HLA-A	22 (4%)	488	0.7332	1	0.089411	0.773	0.86881	1	0.086379	0.773	0.33753	1	1	1	0.12995	0.872	1	1	0.23179	0.988	0.013467	0.373	0.73897	1	0.8136	1	0.61415	1
HRAS	29 (6%)	481	0.40915	1	0.2913	1	0.44745	1	0.87855	1	0.12842	0.872	0.089739	0.773	0.27196	1	1	1	0.87464	1	0.58923	1	0.12838	0.872	0.57757	1	0.39206	1
PIK3CA	94 (18%)	416	0.6664	1	0.68885	1	0.459	1	0.27821	1	0.18075	0.932	0.040847	0.62	1	1	0.47579	1	0.97105	1	0.5985	1	0.34893	1	0.02886	0.613	1	1
EP300	39 (8%)	471	0.28866	1	0.72968	1	0.93989	1	0.69882	1	0.51511	1	0.45489	1	1	1	1	1	0.20068	0.937	0.7413	1	0.82184	1	0.74048	1	0.44483	1
RB1	18 (4%)	492	0.060542	0.728	0.56691	1	0.14193	0.883	0.23897	0.99	0.57925	1	0.0023898	0.187	1	1	1	1	0.71837	1	0.30317	1	0.21453	0.943	0.31377	1	1	1
PTEN	14 (3%)	496	0.28412	1	0.31826	1	0.90822	1	0.29238	1	0.46305	1	1	1	1	1	1	1	0.45502	1	0.16182	0.883	0.51765	1	0.73787	1	1	1
RASA1	17 (3%)	493	0.81593	1	0.78167	1	0.75576	1	0.46197	1	0.95854	1	0.58016	1	0.78337	1	1	1	0.45136	1	0.97289	1	0.75553	1	1	1	0.23772	0.99
MAPK1	9 (2%)	501	0.21295	0.943	0.95176	1	0.86352	1	0.37978	1	0.60957	1	0.71109	1	1	1	1	1	NA	NA	0.43937	1	0.88705	1	0.23277	0.988	1	1
NAP1L2	7 (1%)	503	0.33703	1	0.9054	1	0.23924	0.99	0.67055	1	0.14555	0.883	1	1	1	1	0.10598	0.826	0.54315	1	0.84372	1	0.45972	1	0.47033	1	0.0026364	0.187
KEAP1	22 (4%)	488	0.93051	1	0.097203	0.784	0.10947	0.84	0.0079099	0.265	0.38176	1	0.15025	0.883	0.025228	0.562	0.04161	0.62	0.11415	0.846	0.34569	1	0.82283	1	0.48405	1	0.61415	1
KDM6A	17 (3%)	493	0.34411	1	0.054032	0.716	0.37258	1	0.26432	1	0.80555	1	1	1	0.38799	1	1	1	0.16938	0.899	0.1943	0.932	0.91035	1	0.28612	1	0.6145	1
RHOA	10 (2%)	500	0.48416	1	0.3948	1	1	1	0.41551	1	0.0331	0.62	0.47308	1	0.72511	1	0.14541	0.883	0.65135	1	0.61346	1	0.3154	1	1	1	1	1
CREBBP	35 (7%)	475	0.55711	1	0.03317	0.62	0.74402	1	0.71979	1	0.88575	1	0.56149	1	0.67808	1	0.4371	1	0.80482	1	0.043814	0.627	0.63824	1	0.16259	0.883	1	1
NUDT11	8 (2%)	502	0.4319	1	0.56561	1	0.64379	1	0.88089	1	0.5281	1	0.11426	0.846	0.30289	1	1	1	0.52974	1	0.55851	1	0.34118	1	1	1	0.36541	1
EMG1	4 (1%)	506	0.28562	1	0.49232	1	1	1	0.59476	1	0.3343	1	0.30338	1	0.61264	1	1	1	NA	NA	NA	NA	0.65951	1	1	1	1	1
SMAD4	13 (3%)	497	0.54944	1	0.30217	1	0.73679	1	1	1	0.58774	1	1	1	0.5251	1	1	1	0.37779	1	0.14565	0.883	0.86504	1	1	1	1	1
CUL3	14 (3%)	496	0.54301	1	0.25943	1	0.2147	0.943	0.04039	0.62	0.61921	1	0.36915	1	0.75949	1	1	1	0.77003	1	0.16235	0.883	0.21032	0.943	0.18145	0.932	1	1
TIGD4	7 (1%)	503	0.28726	1	0.17581	0.92	0.26975	1	0.77799	1	0.19154	0.932	0.6797	1	0.66245	1	1	1	0.54597	1	0.43897	1	0.1762	0.92	0.52875	1	1	1
MYH9	22 (4%)	488	0.7663	1	0.60405	1	0.90978	1	0.9624	1	0.76203	1	0.46406	1	0.79689	1	0.29969	1	0.48168	1	0.35459	1	0.61301	1	0.53047	1	0.27997	1
C3ORF59	11 (2%)	499	0.88391	1	0.50193	1	0.95158	1	0.75784	1	0.36112	1	1	1	0.72511	1	1	1	0.9444	1	0.69855	1	0.51038	1	0.6975	1	1	1
HUWE1	45 (9%)	465	0.28499	1	0.34449	1	0.82414	1	0.52491	1	0.45051	1	0.02364	0.558	1	1	1	1	0.26893	1	0.50045	1	0.56867	1	0.073999	0.773	0.28013	1
SLC9A6	5 (1%)	505	0.0097537	0.296	0.79186	1	0.324	1	0.4649	1	0.10637	0.826	0.12998	0.872	0.66245	1	1	1	0.82476	1	NA	NA	0.13807	0.883	1	1	1	1
ZNF623	11 (2%)	499	0.27156	1	0.97937	1	0.95202	1	0.75769	1	0.65196	1	0.50366	1	0.50482	1	1	1	0.93685	1	0.92735	1	0.21933	0.957	0.40692	1	1	1
MLL4	20 (4%)	490	0.43756	1	0.0037812	0.19	0.20153	0.937	0.98452	1	0.066689	0.758	0.078933	0.773	0.79461	1	1	1	0.68787	1	0.056201	0.716	0.096806	0.784	0.53114	1	1	1
CTCF	16 (3%)	494	0.069566	0.758	0.0009986	0.124	0.11885	0.866	1	1	0.43144	1	0.048829	0.676	1	1	1	1	0.6565	1	0.041835	0.62	0.31912	1	0.42502	1	1	1
NCOR1	18 (4%)	492	0.74695	1	0.274	1	0.7156	1	0.52302	1	0.73796	1	0.59359	1	0.57229	1	1	1	0.85185	1	0.40835	1	0.36251	1	0.77955	1	0.25881	1
PTPN14	15 (3%)	495	0.090266	0.773	0.80743	1	0.48974	1	0.78481	1	0.33333	1	1	1	0.55588	1	1	1	0.36489	1	0.53916	1	0.43244	1	0.086709	0.773	0.57656	1
ITGB1	13 (3%)	497	0.40676	1	0.12378	0.866	0.20821	0.943	0.22235	0.957	0.55859	1	0.75863	1	0.50482	1	1	1	0.74532	1	0.95002	1	0.53181	1	1	1	0.52437	1
IRS4	17 (3%)	493	0.79446	1	0.92928	1	0.69196	1	0.75929	1	0.41883	1	0.26601	1	0.55484	1	1	1	0.75252	1	0.98283	1	0.15355	0.883	0.54555	1	0.19605	0.932
SRPX	7 (1%)	503	0.40618	1	0.32878	1	0.43194	1	0.86241	1	0.15206	0.883	0.093935	0.784	1	1	1	1	0.6345	1	0.77352	1	0.078523	0.773	1	1	1	1
KIAA1949	6 (1%)	504	0.23755	0.99	0.56578	1	0.03821	0.62	0.248	1	0.33373	1	1	1	1	1	1	1	0.64302	1	0.24711	1	NA	NA	1	1	1	1
NOTCH2	20 (4%)	490	0.69221	1	0.15313	0.883	0.31043	1	0.81122	1	0.77261	1	0.0087798	0.28	0.78337	1	1	1	0.21142	0.943	0.14096	0.883	0.54185	1	1	1	0.61705	1
GAGE2A	5 (1%)	505	0.60045	1	0.81546	1	0.1511	0.883	0.62967	1	0.081419	0.773	0.32946	1	0.12313	0.866	1	1	NA	NA	NA	NA	0.61254	1	0.095279	0.784	1	1
LCP1	15 (3%)	495	0.92552	1	0.6597	1	0.25972	1	0.082459	0.773	1	1	1	1	0.12062	0.866	1	1	0.72578	1	0.37415	1	0.6278	1	0.72492	1	0.57656	1