Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.012 0.107 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.038 0.157 -9999.0 0.0 -0.485 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.088 0.127 -9999.0 0.0 -0.261 23.0 23.0 LRPAP1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.087 0.126 0.26 23.0 -9999.0 0.0 23.0 SMO/beta Arrestin2 -0.037 0.141 -9999.0 0.0 -0.444 5.0 5.0 SMO -0.041 0.149 -9999.0 0.0 -0.466 5.0 5.0 AKT1 -0.013 0.072 -9999.0 0.0 -0.286 1.0 1.0 ARRB2 0.004 0.001 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.041 0.147 -9999.0 0.0 -0.459 5.0 5.0 STIL -0.063 0.13 -9999.0 0.0 -0.39 3.0 3.0 DHH N/PTCH2 -0.024 0.1 -9999.0 0.0 -0.342 6.0 6.0 DHH N/PTCH1 -0.023 0.116 0.19 4.0 -0.266 9.0 13.0 PIK3CA 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.039 0.139 -9999.0 0.0 -0.478 6.0 6.0 PTHLH 0.009 0.137 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.041 0.147 -9999.0 0.0 -0.459 5.0 5.0 PIK3R1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.009 0.136 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.019 0.093 -9999.0 0.0 -0.284 7.0 7.0 DHH N/Hhip -0.025 0.1 -9999.0 0.0 -0.342 6.0 6.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.041 0.147 -9999.0 0.0 -0.459 5.0 5.0 pancreas development 0.004 0.002 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.032 0.128 -9999.0 0.0 -0.478 5.0 5.0 somite specification -0.041 0.147 -9999.0 0.0 -0.459 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.066 0.137 0.176 2.0 -0.263 19.0 21.0 SHH Np/Cholesterol/PTCH2 -0.067 0.119 -9999.0 0.0 -0.261 18.0 18.0 SHH Np/Cholesterol/Megalin -0.257 0.166 -9999.0 0.0 -0.327 52.0 52.0 SHH -0.091 0.154 -9999.0 0.0 -0.343 18.0 18.0 catabolic process 0.001 0.107 0.232 5.0 -0.3 5.0 10.0 SMO/Vitamin D3 -0.075 0.154 -9999.0 0.0 -0.408 6.0 6.0 SHH Np/Cholesterol/Hhip -0.068 0.118 -9999.0 0.0 -0.261 18.0 18.0 LRP2 -0.347 0.214 -9999.0 0.0 -0.478 48.0 48.0 receptor-mediated endocytosis -0.218 0.182 -9999.0 0.0 -0.459 18.0 18.0 SHH Np/Cholesterol/BOC -0.067 0.119 -9999.0 0.0 -0.261 18.0 18.0 SHH Np/Cholesterol/CDO -0.067 0.119 -9999.0 0.0 -0.261 18.0 18.0 mesenchymal cell differentiation 0.068 0.118 0.26 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 -0.063 0.139 0.2 3.0 -0.263 19.0 22.0 IHH N/PTCH2 -0.018 0.094 -9999.0 0.0 -0.284 7.0 7.0 CDON 0.005 0.001 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.005 0.108 0.249 5.0 -0.302 5.0 10.0 Megalin/LRPAP1 -0.247 0.155 -9999.0 0.0 -0.342 48.0 48.0 PTCH2 0.005 0.001 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.069 0.118 -9999.0 0.0 -0.261 18.0 18.0 PTCH1 0.001 0.107 0.232 5.0 -0.3 5.0 10.0 HHIP 0.004 0.002 -9999.0 0.0 -9999.0 0.0 0.0