Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.001 0.042 -9999.0 0.0 -0.236 2.0 2.0 epithelial cell differentiation 0.003 0.044 -9999.0 0.0 -0.243 2.0 2.0 CYFIP2 -0.01 0.083 -9999.0 0.0 -0.478 2.0 2.0 ENAH -0.002 0.029 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.003 0.041 -9999.0 0.0 -0.233 2.0 2.0 CTNNB1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.001 0.051 -9999.0 0.0 -0.289 2.0 2.0 AQP5 -0.084 0.185 -9999.0 0.0 -0.469 12.0 12.0 CTNND1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.003 0.04 -9999.0 0.0 -0.23 2.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.003 0.04 -9999.0 0.0 -0.23 2.0 2.0 EGF -0.024 0.115 -9999.0 0.0 -0.478 4.0 4.0 NCKAP1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.216 0.237 -9999.0 0.0 -0.465 31.0 31.0 cortical microtubule organization 0.003 0.044 -9999.0 0.0 -0.243 2.0 2.0 GO:0000145 -0.005 0.038 -9999.0 0.0 -0.219 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.004 0.044 -9999.0 0.0 -0.245 2.0 2.0 MLLT4 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.005 0.035 -9999.0 0.0 -0.205 2.0 2.0 ARF6 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.003 0.038 -9999.0 0.0 -0.22 2.0 2.0 PVRL2 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.003 0.041 -9999.0 0.0 -0.233 2.0 2.0 ARF6/GTP 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.01 0.083 -9999.0 0.0 -0.478 2.0 2.0 EGFR/EGFR/EGF/EGF -0.012 0.087 -9999.0 0.0 -0.337 4.0 4.0 RhoA/GDP 0.003 0.041 -9999.0 0.0 -0.231 2.0 2.0 actin cytoskeleton organization -0.004 0.04 -9999.0 0.0 -0.228 2.0 2.0 IGF-1R heterotetramer 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.003 0.002 -9999.0 0.0 -9999.0 0.0 0.0 DIAPH1 -0.009 0.117 -9999.0 0.0 -0.673 2.0 2.0 Wnt receptor signaling pathway -0.003 0.044 0.243 2.0 -9999.0 0.0 2.0 RHOA 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.006 0.035 -9999.0 0.0 -0.207 2.0 2.0 CTNNA1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.004 0.04 -9999.0 0.0 -0.233 2.0 2.0 EFNA1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.004 0.039 -9999.0 0.0 -0.222 2.0 2.0 Ephrin A1/EPHA2 0.002 0.04 -9999.0 0.0 -0.225 2.0 2.0 SEC6/SEC8 -0.004 0.037 -9999.0 0.0 -0.213 2.0 2.0 MGAT3 -0.003 0.041 -9999.0 0.0 -0.233 2.0 2.0 HGF/MET -0.002 0.049 -9999.0 0.0 -0.226 3.0 3.0 HGF -0.002 0.059 -9999.0 0.0 -0.478 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.001 0.042 -9999.0 0.0 -0.238 2.0 2.0 actin cable formation -0.0 0.041 -9999.0 0.0 -0.235 2.0 2.0 KIAA1543 -0.014 0.096 -9999.0 0.0 -0.546 2.0 2.0 KIFC3 -0.007 0.05 -9999.0 0.0 -0.234 3.0 3.0 NCK1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.003 0.041 -9999.0 0.0 -0.233 2.0 2.0 NCK1/GIT1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.003 0.044 -9999.0 0.0 -0.243 2.0 2.0 EXOC4 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.003 0.041 -9999.0 0.0 -0.233 2.0 2.0 PIP5K1C -0.003 0.041 -9999.0 0.0 -0.233 2.0 2.0 LIMA1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.005 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.002 0.033 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.019 0.12 -9999.0 0.0 -0.535 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.001 0.04 -9999.0 0.0 -0.225 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.005 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.01 0.08 -9999.0 0.0 -0.46 2.0 2.0 mol:GTP 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.002 0.036 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.001 0.042 -9999.0 0.0 -0.236 2.0 2.0 regulation of cell-cell adhesion -0.004 0.04 -9999.0 0.0 -0.228 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.001 0.042 -9999.0 0.0 -0.238 2.0 2.0