Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within Nephrin/Neph1 signaling in the kidney podocyte 36.0 1247.0 34.0 -0.427 0.005 1000.0 -1000.0 -0.022 -1000.0 FOXA2 and FOXA3 transcription factor networks 22.0 1036.0 46.0 -1.0 0.014 1000.0 -1000.0 -0.089 -1000.0 PDGFR-alpha signaling pathway 16.0 734.0 44.0 -0.203 0.015 1000.0 -1000.0 -0.02 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 11.0 873.0 78.0 -0.146 0.235 1000.0 -1000.0 -0.054 -1000.0 FOXM1 transcription factor network 10.0 516.0 51.0 -0.058 0.262 1000.0 -1000.0 -0.152 -1000.0 Signaling events mediated by the Hedgehog family 9.0 508.0 52.0 -0.347 0.087 1000.0 -1000.0 -0.03 -1000.0 Glypican 1 network 9.0 441.0 48.0 -0.259 0.01 1000.0 -1000.0 -0.024 -1000.0 Signaling events regulated by Ret tyrosine kinase 9.0 744.0 82.0 -0.119 0.005 1000.0 -1000.0 -0.048 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 8.0 579.0 68.0 -0.412 0.086 1000.0 -1000.0 -0.083 -1000.0 Thromboxane A2 receptor signaling 6.0 689.0 105.0 -0.165 0.042 1000.0 -1000.0 -0.035 -1000.0 HIF-1-alpha transcription factor network 6.0 470.0 76.0 -0.756 0.007 1000.0 -1000.0 -0.098 -1000.0 BMP receptor signaling 6.0 553.0 81.0 -0.384 0.01 1000.0 -1000.0 -0.048 -1000.0 Reelin signaling pathway 6.0 358.0 56.0 -0.113 0.02 1000.0 -1000.0 -0.028 -1000.0 Ephrin B reverse signaling 6.0 333.0 48.0 -0.194 0.008 1000.0 -1000.0 -0.024 -1000.0 IL23-mediated signaling events 6.0 409.0 60.0 -0.259 0.016 1000.0 -1000.0 -0.12 -1000.0 ErbB2/ErbB3 signaling events 5.0 336.0 65.0 -0.06 0.069 1000.0 -1000.0 -0.036 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 5.0 604.0 120.0 -0.317 0.116 1000.0 -1000.0 -0.036 -1000.0 amb2 Integrin signaling 4.0 387.0 82.0 -0.324 0.007 1000.0 -1000.0 -0.033 -1000.0 Endothelins 4.0 405.0 96.0 -0.494 0.016 1000.0 -1000.0 -0.045 -1000.0 LPA4-mediated signaling events 3.0 39.0 12.0 -0.029 0.053 1000.0 -1000.0 -0.007 -1000.0 Circadian rhythm pathway 3.0 67.0 22.0 -0.228 0.005 1000.0 -1000.0 -0.031 -1000.0 Osteopontin-mediated events 3.0 129.0 38.0 -0.299 0.006 1000.0 -1000.0 -0.035 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 3.0 170.0 54.0 -0.113 0.007 1000.0 -1000.0 -0.042 -1000.0 IL4-mediated signaling events 3.0 314.0 91.0 -0.48 0.327 1000.0 -1000.0 -0.159 -1000.0 Glucocorticoid receptor regulatory network 3.0 382.0 114.0 -0.257 0.066 1000.0 -1000.0 -0.043 -1000.0 FoxO family signaling 3.0 242.0 64.0 -0.626 0.094 1000.0 -1000.0 -0.048 -1000.0 Integrins in angiogenesis 3.0 267.0 84.0 -0.362 0.028 1000.0 -1000.0 -0.035 -1000.0 Coregulation of Androgen receptor activity 2.0 187.0 76.0 -0.093 0.327 1000.0 -1000.0 -0.023 -1000.0 IL12-mediated signaling events 2.0 174.0 87.0 -0.066 0.189 1000.0 -1000.0 -0.103 -1000.0 Syndecan-1-mediated signaling events 2.0 86.0 34.0 -0.149 0.005 1000.0 -1000.0 -0.031 -1000.0 Cellular roles of Anthrax toxin 2.0 88.0 39.0 -0.069 0.067 1000.0 -1000.0 -0.012 -1000.0 Fc-epsilon receptor I signaling in mast cells 2.0 199.0 97.0 -0.06 0.01 1000.0 -1000.0 -0.049 -1000.0 IL1-mediated signaling events 2.0 154.0 62.0 -0.193 0.014 1000.0 -1000.0 -0.038 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 2.0 134.0 52.0 -0.288 0.028 1000.0 -1000.0 -0.032 -1000.0 FAS signaling pathway (CD95) 2.0 127.0 47.0 -0.239 0.038 1000.0 -1000.0 -0.027 -1000.0 Nongenotropic Androgen signaling 2.0 137.0 52.0 -0.047 0.024 1000.0 -1000.0 -0.033 -1000.0 TCGA08_rtk_signaling 2.0 55.0 26.0 -0.2 0.009 1000.0 -1000.0 -0.009 -1000.0 LPA receptor mediated events 2.0 232.0 102.0 -0.058 0.03 1000.0 -1000.0 -0.04 -1000.0 IL6-mediated signaling events 2.0 186.0 75.0 -0.101 0.013 1000.0 -1000.0 -0.049 -1000.0 EGFR-dependent Endothelin signaling events 2.0 46.0 21.0 -0.024 0.007 1000.0 -1000.0 -0.028 -1000.0 Plasma membrane estrogen receptor signaling 2.0 228.0 86.0 -0.049 0.046 1000.0 -1000.0 -0.05 -1000.0 Regulation of Androgen receptor activity 2.0 170.0 70.0 -0.039 0.323 1000.0 -1000.0 -0.04 -1000.0 Visual signal transduction: Cones 1.0 46.0 38.0 -0.061 0.027 1000.0 -1000.0 -0.021 -1000.0 JNK signaling in the CD4+ TCR pathway 1.0 18.0 17.0 -0.042 0.014 1000.0 -1000.0 -0.029 -1000.0 Noncanonical Wnt signaling pathway 1.0 29.0 26.0 -0.052 0.013 1000.0 -1000.0 -0.031 -1000.0 Syndecan-2-mediated signaling events 1.0 136.0 69.0 -0.324 0.011 1000.0 -1000.0 -0.022 -1000.0 Signaling events mediated by PTP1B 1.0 118.0 76.0 -0.28 0.019 1000.0 -1000.0 -0.04 -1000.0 p75(NTR)-mediated signaling 1.0 199.0 125.0 -0.195 0.086 1000.0 -1000.0 -0.04 -1000.0 PLK1 signaling events 1.0 156.0 85.0 -0.015 0.051 1000.0 -1000.0 -0.028 -1000.0 IFN-gamma pathway 1.0 76.0 68.0 -0.129 0.025 1000.0 -1000.0 -0.049 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 1.0 60.0 37.0 -0.083 0.013 1000.0 -1000.0 -0.027 -1000.0 Syndecan-3-mediated signaling events 1.0 37.0 35.0 -0.068 0.015 1000.0 -1000.0 -0.034 -1000.0 Signaling mediated by p38-alpha and p38-beta 1.0 74.0 44.0 -0.155 0.027 1000.0 -1000.0 -0.027 -1000.0 TCR signaling in naïve CD8+ T cells 1.0 177.0 93.0 -0.065 0.045 1000.0 -1000.0 -0.046 -1000.0 IL27-mediated signaling events 1.0 68.0 51.0 -0.098 0.086 1000.0 -1000.0 -0.042 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 1.0 133.0 74.0 -0.216 0.014 1000.0 -1000.0 -0.046 -1000.0 TCGA08_retinoblastoma 1.0 9.0 8.0 -0.067 0.064 1000.0 -1000.0 -0.008 -1000.0 Syndecan-4-mediated signaling events 1.0 87.0 67.0 -0.193 0.022 1000.0 -1000.0 -0.042 -1000.0 Angiopoietin receptor Tie2-mediated signaling 1.0 163.0 88.0 -0.122 0.01 1000.0 -1000.0 -0.066 -1000.0 Rapid glucocorticoid signaling 1.0 21.0 20.0 -0.0 0.045 1000.0 -1000.0 -0.012 -1000.0 Visual signal transduction: Rods 1.0 99.0 52.0 -0.061 0.041 1000.0 -1000.0 -0.03 -1000.0 E-cadherin signaling in keratinocytes 1.0 72.0 43.0 -0.132 0.005 1000.0 -1000.0 -0.032 -1000.0 Class IB PI3K non-lipid kinase events 1.0 3.0 3.0 -0.003 -1000.0 1000.0 -1000.0 -0.009 -1000.0 E-cadherin signaling events 1.0 6.0 5.0 -0.01 0.005 1000.0 -1000.0 -0.009 -1000.0 Ras signaling in the CD4+ TCR pathway 1.0 32.0 17.0 -0.04 0.009 1000.0 -1000.0 -0.027 -1000.0 Caspase cascade in apoptosis 0.0 20.0 74.0 -0.011 0.037 1000.0 -1000.0 -0.025 -1000.0 Regulation of nuclear SMAD2/3 signaling 0.0 116.0 136.0 -0.2 0.071 1000.0 -1000.0 -0.046 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 0.0 23.0 0.002 0.012 1000.0 -1000.0 -0.025 -1000.0 Canonical NF-kappaB pathway 0.0 0.0 39.0 -0.0 0.016 1000.0 -1000.0 -0.043 -1000.0 Signaling events mediated by HDAC Class II 0.0 12.0 75.0 -0.032 0.015 1000.0 -1000.0 -0.024 -1000.0 ErbB4 signaling events 0.0 35.0 69.0 -0.043 0.008 1000.0 -1000.0 -0.045 -1000.0 BARD1 signaling events 0.0 22.0 57.0 -0.008 0.013 1000.0 -1000.0 -0.038 -1000.0 Sphingosine 1-phosphate (S1P) pathway 0.0 4.0 28.0 -0.002 0.013 1000.0 -1000.0 -0.025 -1000.0 PLK2 and PLK4 events 0.0 0.0 3.0 0.005 0.008 1000.0 -1000.0 -0.007 -1000.0 Ephrin A reverse signaling 0.0 5.0 7.0 -0.002 0.003 1000.0 -1000.0 -0.009 -1000.0 a4b1 and a4b7 Integrin signaling 0.0 0.0 5.0 0.005 0.007 1000.0 -1000.0 -0.006 -1000.0 Arf6 signaling events 0.0 37.0 62.0 -0.024 0.013 1000.0 -1000.0 -0.028 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 0.0 26.0 85.0 -0.025 0.011 1000.0 -1000.0 -0.035 -1000.0 Hedgehog signaling events mediated by Gli proteins 0.0 45.0 65.0 -0.023 0.019 1000.0 -1000.0 -0.047 -1000.0 Aurora A signaling 0.0 3.0 60.0 -0.002 0.043 1000.0 -1000.0 -0.022 -1000.0 Arf6 downstream pathway 0.0 30.0 43.0 -0.018 0.018 1000.0 -1000.0 -0.026 -1000.0 EPO signaling pathway 0.0 9.0 55.0 -0.017 0.014 1000.0 -1000.0 -0.034 -1000.0 Insulin-mediated glucose transport 0.0 13.0 32.0 -0.091 0.032 1000.0 -1000.0 -0.031 -1000.0 mTOR signaling pathway 0.0 0.0 53.0 -0.0 0.008 1000.0 -1000.0 -0.033 -1000.0 Class I PI3K signaling events mediated by Akt 0.0 13.0 68.0 -0.091 0.08 1000.0 -1000.0 -0.029 -1000.0 Nectin adhesion pathway 0.0 48.0 63.0 -0.024 0.011 1000.0 -1000.0 -0.042 -1000.0 Ceramide signaling pathway 0.0 12.0 76.0 -0.024 0.015 1000.0 -1000.0 -0.028 -1000.0 Signaling events mediated by HDAC Class III 0.0 14.0 40.0 -0.039 0.01 1000.0 -1000.0 -0.016 -1000.0 TRAIL signaling pathway 0.0 16.0 48.0 -0.01 0.015 1000.0 -1000.0 -0.032 -1000.0 ceramide signaling pathway 0.0 22.0 49.0 -0.01 0.01 1000.0 -1000.0 -0.03 -1000.0 HIF-2-alpha transcription factor network 0.0 41.0 43.0 -0.049 0.05 1000.0 -1000.0 -0.049 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 0.0 66.0 83.0 -0.119 0.039 1000.0 -1000.0 -0.04 -1000.0 S1P1 pathway 0.0 9.0 36.0 -0.006 0.006 1000.0 -1000.0 -0.038 -1000.0 Signaling events mediated by HDAC Class I 0.0 2.0 104.0 -0.01 0.013 1000.0 -1000.0 -0.035 -1000.0 Signaling mediated by p38-gamma and p38-delta 0.0 11.0 15.0 -0.006 0.005 1000.0 -1000.0 -0.015 -1000.0 Retinoic acid receptors-mediated signaling 0.0 0.0 58.0 -0.0 0.016 1000.0 -1000.0 -0.047 -1000.0 Paxillin-dependent events mediated by a4b1 0.0 24.0 36.0 -0.083 0.012 1000.0 -1000.0 -0.033 -1000.0 IL2 signaling events mediated by PI3K 0.0 37.0 58.0 -0.017 0.062 1000.0 -1000.0 -0.048 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 0.0 18.0 45.0 -0.011 0.015 1000.0 -1000.0 -0.036 -1000.0 Canonical Wnt signaling pathway 0.0 30.0 51.0 -0.076 0.044 1000.0 -1000.0 -0.049 -1000.0 EPHB forward signaling 0.0 48.0 85.0 -0.017 0.015 1000.0 -1000.0 -0.043 -1000.0 Effects of Botulinum toxin 0.0 0.0 26.0 1000.0 -1000.0 1000.0 -1000.0 -0.02 -1000.0 Glypican 2 network 0.0 0.0 4.0 0.005 0.007 1000.0 -1000.0 -0.01 -1000.0 Calcium signaling in the CD4+ TCR pathway 0.0 4.0 31.0 -0.016 0.013 1000.0 -1000.0 -0.048 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 0.0 12.0 125.0 -0.017 0.017 1000.0 -1000.0 -0.052 -1000.0 Wnt signaling 0.0 4.0 7.0 -0.01 0.005 1000.0 -1000.0 -0.025 -1000.0 E-cadherin signaling in the nascent adherens junction 0.0 64.0 76.0 -0.01 0.01 1000.0 -1000.0 -0.043 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 0.0 27.0 -0.0 0.013 1000.0 -1000.0 -0.025 -1000.0 IL2 signaling events mediated by STAT5 0.0 8.0 22.0 -0.017 0.029 1000.0 -1000.0 -0.037 -1000.0 Class I PI3K signaling events 0.0 12.0 73.0 -0.017 0.031 1000.0 -1000.0 -0.041 -1000.0 Arf6 trafficking events 0.0 11.0 71.0 -0.033 0.018 1000.0 -1000.0 -0.03 -1000.0 Regulation of Telomerase 0.0 63.0 102.0 -0.2 0.018 1000.0 -1000.0 -0.066 -1000.0 BCR signaling pathway 0.0 41.0 99.0 -0.032 0.042 1000.0 -1000.0 -0.048 -1000.0 IGF1 pathway 0.0 10.0 57.0 -0.027 0.056 1000.0 -1000.0 -0.036 -1000.0 Insulin Pathway 0.0 18.0 74.0 -0.017 0.015 1000.0 -1000.0 -0.037 -1000.0 VEGFR1 specific signals 0.0 6.0 56.0 -0.019 0.015 1000.0 -1000.0 -0.031 -1000.0 S1P3 pathway 0.0 11.0 42.0 -0.002 0.009 1000.0 -1000.0 -0.032 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0 14.0 33.0 -0.032 0.015 1000.0 -1000.0 -0.038 -1000.0 PDGFR-beta signaling pathway 0.0 12.0 97.0 -0.02 0.015 1000.0 -1000.0 -0.036 -1000.0 Signaling events mediated by PRL 0.0 16.0 34.0 -0.039 0.01 1000.0 -1000.0 -0.031 -1000.0 S1P4 pathway 0.0 5.0 25.0 -0.002 0.01 1000.0 -1000.0 -0.025 -1000.0 p38 MAPK signaling pathway 0.0 1.0 44.0 -0.001 0.022 1000.0 -1000.0 -0.033 -1000.0 Arf1 pathway 0.0 0.0 54.0 -0.0 0.01 1000.0 -1000.0 -0.019 -1000.0 Alternative NF-kappaB pathway 0.0 0.0 13.0 0.0 0.015 1000.0 -1000.0 -0.012 -1000.0 Aurora B signaling 0.0 61.0 67.0 -0.249 0.056 1000.0 -1000.0 -0.034 -1000.0 Total 261 18015 7026 985.651427502 -1995.38164681 125000 -125000 -4.67894275901 -125000