This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.
Testing the association between mutation status of 57 genes and 13 clinical features across 663 patients, 42 significant findings detected with Q value < 0.25.
-
FAM18B2 mutation correlated to 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', and 'RACE'.
-
TP53 mutation correlated to 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', and 'HISTOLOGICAL_TYPE'.
-
KDM5C mutation correlated to 'GENDER'.
-
SETD2 mutation correlated to 'YEARS_TO_BIRTH'.
-
PBRM1 mutation correlated to 'YEARS_TO_BIRTH', 'HISTOLOGICAL_TYPE', and 'RACE'.
-
NEFH mutation correlated to 'HISTOLOGICAL_TYPE'.
-
VHL mutation correlated to 'HISTOLOGICAL_TYPE' and 'RACE'.
-
MET mutation correlated to 'HISTOLOGICAL_TYPE'.
-
HNRNPM mutation correlated to 'HISTOLOGICAL_TYPE'.
-
NF2 mutation correlated to 'PATHOLOGY_N_STAGE' and 'HISTOLOGICAL_TYPE'.
-
TDG mutation correlated to 'HISTOLOGICAL_TYPE'.
-
MUC5B mutation correlated to 'HISTOLOGICAL_TYPE'.
-
ZNF814 mutation correlated to 'HISTOLOGICAL_TYPE'.
-
CSGALNACT2 mutation correlated to 'HISTOLOGICAL_TYPE'.
-
NFE2L2 mutation correlated to 'YEARS_TO_BIRTH'.
-
ATM mutation correlated to 'PATHOLOGIC_STAGE'.
-
MTOR mutation correlated to 'GENDER'.
-
EGFR mutation correlated to 'PATHOLOGIC_STAGE' and 'PATHOLOGY_T_STAGE'.
-
ZNF598 mutation correlated to 'HISTOLOGICAL_TYPE'.
-
KDM6A mutation correlated to 'YEARS_TO_BIRTH', 'HISTOLOGICAL_TYPE', and 'RACE'.
-
STAM mutation correlated to 'PATHOLOGIC_STAGE' and 'PATHOLOGY_T_STAGE'.
-
SKI mutation correlated to 'HISTOLOGICAL_TYPE'.
-
FAT1 mutation correlated to 'HISTOLOGICAL_TYPE'.
-
CACNA1C mutation correlated to 'PATHOLOGY_M_STAGE'.
-
MLL3 mutation correlated to 'HISTOLOGICAL_TYPE' and 'RACE'.
-
AHNAK2 mutation correlated to 'HISTOLOGICAL_TYPE' and 'RACE'.
-
TTLL6 mutation correlated to 'PATHOLOGY_T_STAGE'.
-
AMAC1L3 mutation correlated to 'HISTOLOGICAL_TYPE'.
Clinical Features |
Time to Death |
YEARS TO BIRTH |
PATHOLOGIC STAGE |
PATHOLOGY T STAGE |
PATHOLOGY N STAGE |
PATHOLOGY M STAGE |
GENDER |
KARNOFSKY PERFORMANCE SCORE |
HISTOLOGICAL TYPE |
NUMBER PACK YEARS SMOKED |
YEAR OF TOBACCO SMOKING ONSET |
RACE | ETHNICITY | ||
nMutated (%) | nWild-Type | logrank test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Wilcoxon-test | Fisher's exact test | Wilcoxon-test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | |
FAM18B2 | 35 (5%) | 628 |
0.405 (1.00) |
0.603 (1.00) |
0.702 (1.00) |
0.876 (1.00) |
0.0139 (0.245) |
1 (1.00) |
0.855 (1.00) |
0.275 (1.00) |
1e-05 (0.000926) |
0.806 (1.00) |
0.00698 (0.181) |
1 (1.00) |
|
TP53 | 35 (5%) | 628 |
0.923 (1.00) |
0.245 (1.00) |
0.00794 (0.19) |
0.00536 (0.152) |
0.0645 (0.583) |
1 (1.00) |
0.361 (1.00) |
0.267 (1.00) |
1e-05 (0.000926) |
0.392 (1.00) |
1 (1.00) |
0.198 (0.988) |
1 (1.00) |
PBRM1 | 138 (21%) | 525 |
0.355 (1.00) |
0.0108 (0.233) |
0.555 (1.00) |
0.46 (1.00) |
0.042 (0.466) |
0.484 (1.00) |
0.616 (1.00) |
0.776 (1.00) |
1e-05 (0.000926) |
0.0126 (0.233) |
0.65 (1.00) |
||
KDM6A | 10 (2%) | 653 |
0.112 (0.776) |
0.0127 (0.233) |
0.422 (1.00) |
0.922 (1.00) |
0.601 (1.00) |
0.744 (1.00) |
0.00794 (0.19) |
0.00011 (0.00741) |
1 (1.00) |
||||
VHL | 195 (29%) | 468 |
0.0162 (0.267) |
0.0638 (0.583) |
0.446 (1.00) |
0.241 (1.00) |
0.0253 (0.368) |
0.8 (1.00) |
0.245 (1.00) |
0.174 (0.921) |
1e-05 (0.000926) |
1e-05 (0.000926) |
1 (1.00) |
||
NF2 | 16 (2%) | 647 |
0.0992 (0.728) |
0.218 (1.00) |
0.0338 (0.455) |
0.121 (0.785) |
3e-05 (0.00222) |
0.0424 (0.466) |
0.795 (1.00) |
0.288 (1.00) |
0.00314 (0.0979) |
0.062 (0.582) |
0.208 (0.988) |
||
EGFR | 6 (1%) | 657 |
0.0515 (0.516) |
0.301 (1.00) |
0.0122 (0.233) |
0.00252 (0.0889) |
0.431 (1.00) |
0.209 (0.988) |
0.67 (1.00) |
0.338 (1.00) |
1 (1.00) |
1 (1.00) |
|||
STAM | 6 (1%) | 657 |
0.702 (1.00) |
0.43 (1.00) |
0.00056 (0.0296) |
0.00202 (0.0748) |
0.0457 (0.481) |
0.101 (0.729) |
0.67 (1.00) |
0.0751 (0.656) |
1 (1.00) |
0.0369 (0.466) |
|||
MLL3 | 38 (6%) | 625 |
0.935 (1.00) |
0.428 (1.00) |
0.267 (1.00) |
0.221 (1.00) |
0.632 (1.00) |
1 (1.00) |
0.38 (1.00) |
0.314 (1.00) |
0.00065 (0.0301) |
0.611 (1.00) |
0.0102 (0.229) |
0.711 (1.00) |
|
AHNAK2 | 33 (5%) | 630 |
0.815 (1.00) |
0.221 (1.00) |
0.155 (0.893) |
0.11 (0.768) |
0.145 (0.857) |
0.564 (1.00) |
0.575 (1.00) |
0.773 (1.00) |
0.00172 (0.0729) |
0.692 (1.00) |
0.131 (0.814) |
0.00396 (0.117) |
0.648 (1.00) |
KDM5C | 28 (4%) | 635 |
0.0379 (0.466) |
0.0413 (0.466) |
0.635 (1.00) |
0.703 (1.00) |
1 (1.00) |
0.779 (1.00) |
0.0071 (0.181) |
0.0269 (0.384) |
1 (1.00) |
0.385 (1.00) |
|||
SETD2 | 56 (8%) | 607 |
0.0801 (0.674) |
0.0128 (0.233) |
0.0636 (0.583) |
0.0705 (0.63) |
0.424 (1.00) |
0.3 (1.00) |
0.558 (1.00) |
0.42 (1.00) |
0.14 (0.857) |
0.817 (1.00) |
0.497 (1.00) |
||
NEFH | 16 (2%) | 647 |
0.311 (1.00) |
0.374 (1.00) |
0.276 (1.00) |
0.443 (1.00) |
1 (1.00) |
0.324 (1.00) |
0.596 (1.00) |
0.92 (1.00) |
0.00317 (0.0979) |
0.28 (1.00) |
0.125 (0.793) |
1 (1.00) |
|
MET | 19 (3%) | 644 |
0.573 (1.00) |
0.817 (1.00) |
0.463 (1.00) |
0.925 (1.00) |
0.0992 (0.728) |
1 (1.00) |
1 (1.00) |
1e-05 (0.000926) |
0.24 (1.00) |
0.775 (1.00) |
0.143 (0.857) |
1 (1.00) |
|
HNRNPM | 12 (2%) | 651 |
0.315 (1.00) |
0.486 (1.00) |
0.459 (1.00) |
0.0601 (0.578) |
0.343 (1.00) |
0.6 (1.00) |
0.558 (1.00) |
0.644 (1.00) |
2e-05 (0.00165) |
0.269 (1.00) |
1 (1.00) |
||
TDG | 5 (1%) | 658 |
0.245 (1.00) |
0.442 (1.00) |
1 (1.00) |
0.116 (0.785) |
0.344 (1.00) |
1 (1.00) |
0.664 (1.00) |
0.00184 (0.0729) |
0.477 (1.00) |
1 (1.00) |
|||
MUC5B | 32 (5%) | 631 |
0.568 (1.00) |
0.914 (1.00) |
0.442 (1.00) |
0.461 (1.00) |
0.196 (0.988) |
0.229 (1.00) |
0.452 (1.00) |
0.242 (1.00) |
1e-05 (0.000926) |
1 (1.00) |
0.847 (1.00) |
0.401 (1.00) |
1 (1.00) |
ZNF814 | 13 (2%) | 650 |
0.202 (0.988) |
0.252 (1.00) |
0.133 (0.824) |
0.251 (1.00) |
0.431 (1.00) |
1 (1.00) |
0.0414 (0.466) |
0.00046 (0.0262) |
0.332 (1.00) |
1 (1.00) |
|||
CSGALNACT2 | 8 (1%) | 655 |
0.114 (0.782) |
0.498 (1.00) |
0.751 (1.00) |
0.495 (1.00) |
1 (1.00) |
0.6 (1.00) |
0.457 (1.00) |
0.00312 (0.0979) |
0.122 (0.785) |
1 (1.00) |
|||
NFE2L2 | 10 (2%) | 653 |
0.944 (1.00) |
0.0118 (0.233) |
0.737 (1.00) |
0.779 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.466 (1.00) |
0.405 (1.00) |
1 (1.00) |
|||
ATM | 16 (2%) | 647 |
0.471 (1.00) |
0.169 (0.921) |
0.00986 (0.228) |
0.0213 (0.322) |
1 (1.00) |
0.438 (1.00) |
0.435 (1.00) |
0.125 (0.793) |
0.557 (1.00) |
0.496 (1.00) |
|||
MTOR | 32 (5%) | 631 |
0.0771 (0.656) |
0.0461 (0.481) |
0.444 (1.00) |
0.699 (1.00) |
1 (1.00) |
0.177 (0.929) |
0.0122 (0.233) |
0.0319 (0.438) |
0.0154 (0.266) |
0.875 (1.00) |
0.711 (1.00) |
||
ZNF598 | 11 (2%) | 652 |
0.419 (1.00) |
0.5 (1.00) |
0.648 (1.00) |
0.928 (1.00) |
0.0198 (0.306) |
0.101 (0.729) |
0.346 (1.00) |
0.0837 (0.689) |
1e-05 (0.000926) |
0.179 (0.934) |
0.267 (1.00) |
0.496 (1.00) |
|
SKI | 9 (1%) | 654 |
0.592 (1.00) |
0.725 (1.00) |
0.546 (1.00) |
0.698 (1.00) |
0.43 (1.00) |
1 (1.00) |
0.726 (1.00) |
0.00187 (0.0729) |
0.733 (1.00) |
0.265 (1.00) |
1 (1.00) |
||
FAT1 | 21 (3%) | 642 |
0.412 (1.00) |
0.4 (1.00) |
0.328 (1.00) |
0.266 (1.00) |
0.291 (1.00) |
1 (1.00) |
0.816 (1.00) |
0.00062 (0.0301) |
0.837 (1.00) |
0.0614 (0.582) |
0.622 (1.00) |
||
CACNA1C | 17 (3%) | 646 |
0.936 (1.00) |
0.994 (1.00) |
0.0569 (0.555) |
0.506 (1.00) |
0.0192 (0.306) |
0.00554 (0.152) |
0.799 (1.00) |
0.808 (1.00) |
0.316 (1.00) |
0.569 (1.00) |
0.591 (1.00) |
||
TTLL6 | 6 (1%) | 657 |
0.667 (1.00) |
0.121 (0.785) |
0.0407 (0.466) |
0.0129 (0.233) |
1 (1.00) |
1 (1.00) |
0.421 (1.00) |
0.0763 (0.656) |
0.542 (1.00) |
1 (1.00) |
|||
AMAC1L3 | 8 (1%) | 655 |
0.128 (0.802) |
0.3 (1.00) |
0.147 (0.866) |
0.273 (1.00) |
1 (1.00) |
1 (1.00) |
0.721 (1.00) |
0.00024 (0.0148) |
0.599 (1.00) |
1 (1.00) |
|||
PTEN | 26 (4%) | 637 |
0.714 (1.00) |
0.903 (1.00) |
0.262 (1.00) |
0.341 (1.00) |
0.162 (0.91) |
0.346 (1.00) |
0.834 (1.00) |
0.579 (1.00) |
0.0957 (0.728) |
0.884 (1.00) |
0.923 (1.00) |
0.502 (1.00) |
1 (1.00) |
GPR50 | 5 (1%) | 658 |
0.44 (1.00) |
0.32 (1.00) |
0.761 (1.00) |
0.852 (1.00) |
1 (1.00) |
0.347 (1.00) |
0.606 (1.00) |
0.477 (1.00) |
1 (1.00) |
||||
STAG2 | 14 (2%) | 649 |
0.996 (1.00) |
0.0158 (0.266) |
0.16 (0.909) |
0.0974 (0.728) |
1 (1.00) |
0.664 (1.00) |
0.258 (1.00) |
0.17 (0.921) |
0.493 (1.00) |
1 (1.00) |
|||
KDELR3 | 6 (1%) | 657 |
0.582 (1.00) |
0.827 (1.00) |
0.275 (1.00) |
0.0427 (0.466) |
1 (1.00) |
1 (1.00) |
0.67 (1.00) |
0.0762 (0.656) |
0.542 (1.00) |
1 (1.00) |
|||
SLC6A14 | 5 (1%) | 658 |
0.793 (1.00) |
0.59 (1.00) |
0.217 (1.00) |
0.173 (0.921) |
0.0903 (0.719) |
1 (1.00) |
0.347 (1.00) |
0.249 (1.00) |
1 (1.00) |
1 (1.00) |
|||
PIK3CA | 12 (2%) | 651 |
0.914 (1.00) |
0.214 (1.00) |
0.206 (0.988) |
0.202 (0.988) |
1 (1.00) |
0.202 (0.988) |
0.121 (0.785) |
0.48 (1.00) |
0.702 (1.00) |
0.496 (1.00) |
|||
EMG1 | 4 (1%) | 659 |
0.204 (0.988) |
0.932 (1.00) |
0.527 (1.00) |
0.255 (1.00) |
1 (1.00) |
1 (1.00) |
0.723 (1.00) |
1 (1.00) |
1 (1.00) |
||||
RIMBP3 | 5 (1%) | 658 |
0.318 (1.00) |
0.315 (1.00) |
0.625 (1.00) |
0.0906 (0.719) |
1 (1.00) |
1 (1.00) |
0.347 (1.00) |
0.0829 (0.689) |
1 (1.00) |
1 (1.00) |
|||
RAI1 | 7 (1%) | 656 |
0.802 (1.00) |
0.709 (1.00) |
0.257 (1.00) |
0.108 (0.759) |
1 (1.00) |
0.465 (1.00) |
0.242 (1.00) |
0.161 (0.909) |
1 (1.00) |
1 (1.00) |
|||
FAM160B2 | 4 (1%) | 659 |
0.223 (1.00) |
0.731 (1.00) |
0.312 (1.00) |
0.652 (1.00) |
0.374 (1.00) |
0.612 (1.00) |
0.387 (1.00) |
1 (1.00) |
1 (1.00) |
||||
DPCR1 | 8 (1%) | 655 |
0.686 (1.00) |
0.236 (1.00) |
0.222 (1.00) |
0.736 (1.00) |
0.0417 (0.466) |
0.721 (1.00) |
0.743 (1.00) |
0.649 (1.00) |
1 (1.00) |
||||
CYP4F11 | 5 (1%) | 658 |
0.894 (1.00) |
0.479 (1.00) |
0.142 (0.857) |
0.0444 (0.477) |
0.506 (1.00) |
0.465 (1.00) |
1 (1.00) |
0.343 (1.00) |
1 (1.00) |
1 (1.00) |
|||
NUDT11 | 5 (1%) | 658 |
0.498 (1.00) |
0.19 (0.978) |
0.688 (1.00) |
0.497 (1.00) |
1 (1.00) |
0.664 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
||||
PARD6B | 5 (1%) | 658 |
0.668 (1.00) |
0.0499 (0.514) |
0.427 (1.00) |
0.495 (1.00) |
1 (1.00) |
0.17 (0.921) |
0.173 (0.921) |
0.477 (1.00) |
1 (1.00) |
||||
RHEB | 3 (0%) | 660 |
0.81 (1.00) |
0.84 (1.00) |
0.69 (1.00) |
0.74 (1.00) |
0.268 (1.00) |
0.275 (1.00) |
1 (1.00) |
0.32 (1.00) |
1 (1.00) |
||||
SLC16A1 | 3 (0%) | 660 |
0.387 (1.00) |
0.194 (0.988) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.319 (1.00) |
0.185 (0.957) |
||||
THBS1 | 10 (2%) | 653 |
0.985 (1.00) |
0.154 (0.891) |
0.787 (1.00) |
1 (1.00) |
0.601 (1.00) |
0.507 (1.00) |
0.469 (1.00) |
1 (1.00) |
1 (1.00) |
||||
SH3BP2 | 4 (1%) | 659 |
0.532 (1.00) |
0.579 (1.00) |
1 (1.00) |
0.652 (1.00) |
1 (1.00) |
0.612 (1.00) |
0.099 (0.728) |
0.405 (1.00) |
1 (1.00) |
||||
NASP | 4 (1%) | 659 |
0.202 (0.988) |
0.336 (1.00) |
0.219 (1.00) |
0.332 (1.00) |
1 (1.00) |
0.121 (0.785) |
0.0358 (0.466) |
1 (1.00) |
0.239 (1.00) |
||||
PCK1 | 5 (1%) | 658 |
0.166 (0.921) |
0.447 (1.00) |
0.68 (1.00) |
0.344 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.478 (1.00) |
1 (1.00) |
|||
TPPP | 3 (0%) | 660 |
0.788 (1.00) |
0.461 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.0409 (0.466) |
0.273 (1.00) |
0.0197 (0.306) |
1 (1.00) |
||||
PAM | 4 (1%) | 659 |
0.231 (1.00) |
0.949 (1.00) |
0.776 (1.00) |
1 (1.00) |
0.345 (1.00) |
1 (1.00) |
1 (1.00) |
0.0979 (0.728) |
0.365 (1.00) |
0.323 (1.00) |
1 (1.00) |
||
GAPDHS | 5 (1%) | 658 |
0.3 (1.00) |
0.402 (1.00) |
0.915 (1.00) |
0.604 (1.00) |
1 (1.00) |
1 (1.00) |
0.25 (1.00) |
0.171 (0.921) |
1 (1.00) |
||||
TMCO3 | 7 (1%) | 656 |
0.464 (1.00) |
0.554 (1.00) |
0.342 (1.00) |
0.625 (1.00) |
0.429 (1.00) |
1 (1.00) |
0.242 (1.00) |
1 (1.00) |
0.03 (0.419) |
0.289 (1.00) |
|||
RPL7A | 3 (0%) | 660 |
0.757 (1.00) |
0.204 (0.988) |
0.587 (1.00) |
1 (1.00) |
0.144 (0.857) |
0.555 (1.00) |
0.0228 (0.338) |
0.323 (1.00) |
1 (1.00) |
||||
ARHGAP35 | 7 (1%) | 656 |
0.117 (0.785) |
0.854 (1.00) |
0.107 (0.759) |
0.234 (1.00) |
1 (1.00) |
0.209 (0.988) |
0.698 (1.00) |
0.849 (1.00) |
0.0407 (0.466) |
1 (1.00) |
|||
JMJD1C | 10 (2%) | 653 |
0.15 (0.878) |
0.888 (1.00) |
1 (1.00) |
0.846 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.354 (1.00) |
1 (1.00) |
0.0913 (0.719) |
|||
TRAPPC9 | 5 (1%) | 658 |
0.309 (1.00) |
0.71 (1.00) |
0.762 (1.00) |
0.853 (1.00) |
1 (1.00) |
0.0508 (0.516) |
0.0539 (0.532) |
0.408 (1.00) |
1 (1.00) |
||||
MED16 | 4 (1%) | 659 |
0.0352 (0.466) |
0.842 (1.00) |
0.406 (1.00) |
0.33 (1.00) |
0.0882 (0.718) |
1 (1.00) |
0.612 (1.00) |
0.098 (0.728) |
1 (1.00) |
1 (1.00) |
P value = 0.0139 (Fisher's exact test), Q value = 0.24
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 272 | 35 | 6 |
FAM18B2 MUTATED | 4 | 3 | 1 |
FAM18B2 WILD-TYPE | 268 | 32 | 5 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00093
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
FAM18B2 MUTATED | 0 | 0 | 35 |
FAM18B2 WILD-TYPE | 66 | 436 | 126 |
P value = 0.00698 (Fisher's exact test), Q value = 0.18
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 10 | 66 | 565 |
FAM18B2 MUTATED | 1 | 0 | 8 | 22 |
FAM18B2 WILD-TYPE | 1 | 10 | 58 | 543 |
P value = 0.00794 (Fisher's exact test), Q value = 0.19
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 325 | 76 | 163 | 88 |
TP53 MUTATED | 12 | 10 | 6 | 7 |
TP53 WILD-TYPE | 313 | 66 | 157 | 81 |
P value = 0.00536 (Fisher's exact test), Q value = 0.15
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 337 | 95 | 221 | 10 |
TP53 MUTATED | 12 | 11 | 10 | 2 |
TP53 WILD-TYPE | 325 | 84 | 211 | 8 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00093
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
TP53 MUTATED | 22 | 9 | 4 |
TP53 WILD-TYPE | 44 | 427 | 157 |
P value = 0.0071 (Fisher's exact test), Q value = 0.18
nPatients | FEMALE | MALE |
---|---|---|
ALL | 229 | 434 |
KDM5C MUTATED | 3 | 25 |
KDM5C WILD-TYPE | 226 | 409 |
P value = 0.0128 (Wilcoxon-test), Q value = 0.23
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 660 | 59.5 (12.6) |
SETD2 MUTATED | 56 | 63.3 (10.8) |
SETD2 WILD-TYPE | 604 | 59.2 (12.7) |
P value = 0.0108 (Wilcoxon-test), Q value = 0.23
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 660 | 59.5 (12.6) |
PBRM1 MUTATED | 138 | 62.1 (10.9) |
PBRM1 WILD-TYPE | 522 | 58.9 (13.0) |
P value = 1e-05 (Fisher's exact test), Q value = 0.00093
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
PBRM1 MUTATED | 1 | 131 | 6 |
PBRM1 WILD-TYPE | 65 | 305 | 155 |
P value = 0.0126 (Fisher's exact test), Q value = 0.23
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 10 | 66 | 565 |
PBRM1 MUTATED | 0 | 1 | 5 | 128 |
PBRM1 WILD-TYPE | 2 | 9 | 61 | 437 |
P value = 0.00317 (Fisher's exact test), Q value = 0.098
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
NEFH MUTATED | 0 | 6 | 10 |
NEFH WILD-TYPE | 66 | 430 | 151 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00093
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
VHL MUTATED | 1 | 192 | 2 |
VHL WILD-TYPE | 65 | 244 | 159 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00093
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 10 | 66 | 565 |
VHL MUTATED | 0 | 2 | 2 | 189 |
VHL WILD-TYPE | 2 | 8 | 64 | 376 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00093
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
MET MUTATED | 0 | 4 | 15 |
MET WILD-TYPE | 66 | 432 | 146 |
P value = 2e-05 (Fisher's exact test), Q value = 0.0016
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
HNRNPM MUTATED | 1 | 1 | 10 |
HNRNPM WILD-TYPE | 65 | 435 | 151 |
P value = 3e-05 (Fisher's exact test), Q value = 0.0022
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 272 | 35 | 6 |
NF2 MUTATED | 1 | 6 | 0 |
NF2 WILD-TYPE | 271 | 29 | 6 |
P value = 0.00314 (Fisher's exact test), Q value = 0.098
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
NF2 MUTATED | 0 | 6 | 10 |
NF2 WILD-TYPE | 66 | 430 | 151 |
P value = 0.00184 (Fisher's exact test), Q value = 0.073
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
TDG MUTATED | 0 | 0 | 5 |
TDG WILD-TYPE | 66 | 436 | 156 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00093
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
MUC5B MUTATED | 12 | 6 | 14 |
MUC5B WILD-TYPE | 54 | 430 | 147 |
P value = 0.00046 (Fisher's exact test), Q value = 0.026
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
ZNF814 MUTATED | 3 | 2 | 8 |
ZNF814 WILD-TYPE | 63 | 434 | 153 |
P value = 0.00312 (Fisher's exact test), Q value = 0.098
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
CSGALNACT2 MUTATED | 2 | 1 | 5 |
CSGALNACT2 WILD-TYPE | 64 | 435 | 156 |
P value = 0.0118 (Wilcoxon-test), Q value = 0.23
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 660 | 59.5 (12.6) |
NFE2L2 MUTATED | 10 | 68.9 (7.0) |
NFE2L2 WILD-TYPE | 650 | 59.4 (12.6) |
P value = 0.00986 (Fisher's exact test), Q value = 0.23
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 325 | 76 | 163 | 88 |
ATM MUTATED | 6 | 6 | 1 | 3 |
ATM WILD-TYPE | 319 | 70 | 162 | 85 |
P value = 0.0122 (Fisher's exact test), Q value = 0.23
nPatients | FEMALE | MALE |
---|---|---|
ALL | 229 | 434 |
MTOR MUTATED | 18 | 14 |
MTOR WILD-TYPE | 211 | 420 |
P value = 0.0122 (Fisher's exact test), Q value = 0.23
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 325 | 76 | 163 | 88 |
EGFR MUTATED | 0 | 0 | 4 | 2 |
EGFR WILD-TYPE | 325 | 76 | 159 | 86 |
P value = 0.00252 (Fisher's exact test), Q value = 0.089
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 337 | 95 | 221 | 10 |
EGFR MUTATED | 0 | 0 | 5 | 1 |
EGFR WILD-TYPE | 337 | 95 | 216 | 9 |
P value = 1e-05 (Fisher's exact test), Q value = 0.00093
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
ZNF598 MUTATED | 1 | 0 | 10 |
ZNF598 WILD-TYPE | 65 | 436 | 151 |
P value = 0.0127 (Wilcoxon-test), Q value = 0.23
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 660 | 59.5 (12.6) |
KDM6A MUTATED | 8 | 70.6 (10.1) |
KDM6A WILD-TYPE | 652 | 59.4 (12.6) |
P value = 0.00794 (Fisher's exact test), Q value = 0.19
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
KDM6A MUTATED | 0 | 3 | 7 |
KDM6A WILD-TYPE | 66 | 433 | 154 |
P value = 0.00011 (Fisher's exact test), Q value = 0.0074
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 10 | 66 | 565 |
KDM6A MUTATED | 1 | 0 | 4 | 2 |
KDM6A WILD-TYPE | 1 | 10 | 62 | 563 |
P value = 0.00056 (Fisher's exact test), Q value = 0.03
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 325 | 76 | 163 | 88 |
STAM MUTATED | 0 | 3 | 0 | 3 |
STAM WILD-TYPE | 325 | 73 | 163 | 85 |
P value = 0.00202 (Fisher's exact test), Q value = 0.075
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 337 | 95 | 221 | 10 |
STAM MUTATED | 0 | 3 | 2 | 1 |
STAM WILD-TYPE | 337 | 92 | 219 | 9 |
P value = 0.00187 (Fisher's exact test), Q value = 0.073
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
SKI MUTATED | 2 | 1 | 6 |
SKI WILD-TYPE | 64 | 435 | 155 |
P value = 0.00062 (Fisher's exact test), Q value = 0.03
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
FAT1 MUTATED | 1 | 7 | 13 |
FAT1 WILD-TYPE | 65 | 429 | 148 |
P value = 0.00554 (Fisher's exact test), Q value = 0.15
nPatients | 0 | 1 |
---|---|---|
ALL | 463 | 78 |
CACNA1C MUTATED | 7 | 6 |
CACNA1C WILD-TYPE | 456 | 72 |
P value = 0.00065 (Fisher's exact test), Q value = 0.03
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
MLL3 MUTATED | 9 | 15 | 14 |
MLL3 WILD-TYPE | 57 | 421 | 147 |
P value = 0.0102 (Fisher's exact test), Q value = 0.23
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 10 | 66 | 565 |
MLL3 MUTATED | 0 | 1 | 10 | 26 |
MLL3 WILD-TYPE | 2 | 9 | 56 | 539 |
P value = 0.00172 (Fisher's exact test), Q value = 0.073
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
AHNAK2 MUTATED | 10 | 16 | 7 |
AHNAK2 WILD-TYPE | 56 | 420 | 154 |
P value = 0.00396 (Fisher's exact test), Q value = 0.12
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 10 | 66 | 565 |
AHNAK2 MUTATED | 1 | 2 | 6 | 22 |
AHNAK2 WILD-TYPE | 1 | 8 | 60 | 543 |
P value = 0.0129 (Fisher's exact test), Q value = 0.23
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 337 | 95 | 221 | 10 |
TTLL6 MUTATED | 1 | 4 | 1 | 0 |
TTLL6 WILD-TYPE | 336 | 91 | 220 | 10 |
P value = 0.00024 (Fisher's exact test), Q value = 0.015
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 436 | 161 |
AMAC1L3 MUTATED | 5 | 1 | 2 |
AMAC1L3 WILD-TYPE | 61 | 435 | 159 |
-
Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline
-
Processed Mutation data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/KIPAN-TP/20230417/transformed.cor.cli.txt
-
Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/KIPAN-TP/19775252/KIPAN-TP.merged_data.txt
-
Number of patients = 663
-
Number of significantly mutated genes = 57
-
Number of selected clinical features = 13
-
Exclude genes that fewer than K tumors have mutations, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.