Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.008 0.056 -9999.0 0.0 -0.19 6.0 6.0 epithelial cell differentiation 0.042 0.059 -9999.0 0.0 -0.172 5.0 5.0 CYFIP2 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.002 0.159 0.667 4.0 -0.229 1.0 5.0 EGFR -0.012 0.109 -9999.0 0.0 -0.346 8.0 8.0 EPHA2 0.026 0.041 -9999.0 0.0 -0.346 1.0 1.0 MYO6 0.002 0.099 0.26 8.0 -0.198 5.0 13.0 CTNNB1 0.027 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.054 0.024 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.008 0.093 -9999.0 0.0 -0.547 2.0 2.0 CTNND1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.001 0.095 0.258 8.0 -9999.0 0.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.083 0.214 4.0 -0.173 11.0 15.0 EGF -0.022 0.103 -9999.0 0.0 -0.346 7.0 7.0 NCKAP1 0.028 0.014 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.033 0.146 0.387 1.0 -0.478 7.0 8.0 cortical microtubule organization 0.042 0.059 -9999.0 0.0 -0.172 5.0 5.0 GO:0000145 0.001 0.091 0.245 8.0 -0.16 1.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.047 0.061 -9999.0 0.0 -0.174 5.0 5.0 MLLT4 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.041 0.057 -9999.0 0.0 -0.174 12.0 12.0 ARF6 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.046 0.084 -9999.0 0.0 -0.198 8.0 8.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.058 0.172 3.0 -9999.0 0.0 3.0 PVRL2 0.031 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.013 0.056 0.173 4.0 -9999.0 0.0 4.0 ARF6/GTP 0.054 0.084 -9999.0 0.0 -0.186 8.0 8.0 CDH1 -0.002 0.097 -9999.0 0.0 -0.346 6.0 6.0 EGFR/EGFR/EGF/EGF -0.005 0.101 -9999.0 0.0 -0.202 15.0 15.0 RhoA/GDP 0.039 0.066 -9999.0 0.0 -0.167 7.0 7.0 actin cytoskeleton organization -0.011 0.07 0.193 5.0 -0.198 5.0 10.0 IGF-1R heterotetramer 0.027 0.041 -9999.0 0.0 -0.345 1.0 1.0 GIT1 0.025 0.041 -9999.0 0.0 -0.346 1.0 1.0 IGF1R 0.027 0.041 -9999.0 0.0 -0.346 1.0 1.0 IGF1 0.0 0.09 -9999.0 0.0 -0.346 5.0 5.0 DIAPH1 0.036 0.113 -9999.0 0.0 -0.481 3.0 3.0 Wnt receptor signaling pathway -0.042 0.059 0.172 5.0 -9999.0 0.0 5.0 RHOA 0.02 0.057 -9999.0 0.0 -0.346 2.0 2.0 RhoA/GTP -0.043 0.058 -9999.0 0.0 -0.172 13.0 13.0 CTNNA1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.011 0.071 0.195 5.0 -0.202 5.0 10.0 EFNA1 -0.005 0.109 -9999.0 0.0 -0.346 8.0 8.0 LPP -0.022 0.063 0.164 4.0 -0.18 2.0 6.0 Ephrin A1/EPHA2 0.017 0.084 -9999.0 0.0 -0.178 12.0 12.0 SEC6/SEC8 -0.032 0.049 -9999.0 0.0 -0.181 7.0 7.0 MGAT3 -0.031 0.084 0.216 4.0 -0.175 11.0 15.0 HGF/MET 0.028 0.064 -9999.0 0.0 -0.17 7.0 7.0 HGF 0.013 0.07 -9999.0 0.0 -0.346 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.008 0.056 -9999.0 0.0 -0.191 6.0 6.0 actin cable formation 0.037 0.176 0.616 6.0 -9999.0 0.0 6.0 KIAA1543 0.003 0.09 0.247 8.0 -0.16 5.0 13.0 KIFC3 -0.013 0.071 0.216 4.0 -0.318 1.0 5.0 NCK1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.009 0.088 -9999.0 0.0 -0.346 5.0 5.0 ACTN1 -0.008 0.094 0.249 7.0 -0.177 4.0 11.0 NCK1/GIT1 0.04 0.033 -9999.0 0.0 -0.242 1.0 1.0 mol:GDP 0.042 0.059 -9999.0 0.0 -0.172 5.0 5.0 EXOC4 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.015 0.073 0.216 4.0 -0.193 6.0 10.0 PIP5K1C 0.001 0.096 0.26 8.0 -0.169 1.0 9.0 LIMA1 0.022 0.044 -9999.0 0.0 -0.346 1.0 1.0 ABI1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.003 0.171 0.616 5.0 -0.262 1.0 6.0 adherens junction assembly 0.019 0.121 0.406 5.0 -0.341 2.0 7.0 IGF-1R heterotetramer/IGF1 0.02 0.079 -9999.0 0.0 -0.181 10.0 10.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.003 0.094 0.26 8.0 -0.168 5.0 13.0 mol:GTP 0.044 0.083 -9999.0 0.0 -0.197 8.0 8.0 establishment of epithelial cell apical/basal polarity -0.013 0.106 0.362 3.0 -0.344 2.0 5.0 cortical actin cytoskeleton stabilization 0.008 0.056 -9999.0 0.0 -0.19 6.0 6.0 regulation of cell-cell adhesion -0.011 0.07 0.193 5.0 -0.198 5.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.008 0.056 -9999.0 0.0 -0.191 6.0 6.0