E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.069 0.125 -9999.0 0.0 -0.303 89.0 89.0 KLHL20 -0.022 0.06 0.158 2.0 -0.218 11.0 13.0 CYFIP2 0.009 0.05 -9999.0 0.0 -0.417 7.0 7.0 Rac1/GDP -0.034 0.078 0.242 6.0 -0.276 12.0 18.0 ENAH -0.065 0.123 -9999.0 0.0 -0.306 85.0 85.0 AP1M1 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.028 0.045 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.022 0.034 -9999.0 0.0 -0.154 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.026 0.054 -9999.0 0.0 -0.237 17.0 17.0 RAPGEF1 -0.063 0.119 0.224 6.0 -0.362 18.0 24.0 CTNND1 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.06 0.13 -9999.0 0.0 -0.307 92.0 92.0 CRK -0.068 0.12 -9999.0 0.0 -0.298 69.0 69.0 E-cadherin/gamma catenin/alpha catenin 0.02 0.056 -9999.0 0.0 -0.271 16.0 16.0 alphaE/beta7 Integrin 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.034 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.06 0.12 -9999.0 0.0 -0.305 79.0 79.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.028 -9999.0 0.0 -0.162 2.0 2.0 MLLT4 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.038 0.035 -9999.0 0.0 -0.206 2.0 2.0 ARF6 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.016 0.065 -9999.0 0.0 -0.313 19.0 19.0 TIAM1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.02 0.048 -9999.0 0.0 -0.222 14.0 14.0 AKT1 -0.023 0.029 0.113 1.0 -9999.0 0.0 1.0 PIK3R1 0.017 0.02 -9999.0 0.0 -0.417 1.0 1.0 CDH1 0.005 0.077 -9999.0 0.0 -0.417 17.0 17.0 RhoA/GDP -0.026 0.086 0.286 10.0 -0.275 13.0 23.0 actin cytoskeleton organization -0.014 0.05 0.142 13.0 -0.161 10.0 23.0 CDC42/GDP -0.03 0.102 0.318 16.0 -0.276 13.0 29.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.002 0.046 -9999.0 0.0 -0.239 16.0 16.0 ITGB7 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.023 0.05 -9999.0 0.0 -0.237 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.015 0.042 -9999.0 0.0 -0.216 14.0 14.0 mol:GDP -0.033 0.11 0.333 16.0 -0.314 13.0 29.0 CDC42/GTP/IQGAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.017 0.033 -9999.0 0.0 -0.417 3.0 3.0 p120 catenin/RhoA/GDP -0.043 0.069 0.262 3.0 -0.281 13.0 16.0 RAC1/GTP/IQGAP1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.015 0.009 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.004 0.044 0.134 22.0 -9999.0 0.0 22.0 NME1 0.02 0.008 0.188 1.0 -9999.0 0.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.068 0.125 -9999.0 0.0 -0.304 89.0 89.0 regulation of cell-cell adhesion -0.027 0.037 -9999.0 0.0 -0.189 1.0 1.0 WASF2 -0.005 0.031 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.025 0.054 0.211 5.0 -9999.0 0.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.034 0.057 -9999.0 0.0 -0.242 16.0 16.0 CCND1 -0.006 0.05 0.157 18.0 -9999.0 0.0 18.0 VAV2 -0.065 0.16 0.357 1.0 -0.522 27.0 28.0 RAP1/GDP -0.024 0.066 0.235 6.0 -0.261 5.0 11.0 adherens junction assembly -0.067 0.122 -9999.0 0.0 -0.295 91.0 91.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.024 0.066 -9999.0 0.0 -0.236 16.0 16.0 E-cadherin/beta catenin -0.007 0.059 -9999.0 0.0 -0.318 18.0 18.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.067 0.123 -9999.0 0.0 -0.302 88.0 88.0 PIK3CA 0.018 0.02 -9999.0 0.0 -0.417 1.0 1.0 Rac1/GTP -0.039 0.08 0.163 6.0 -0.335 13.0 19.0 E-cadherin/beta catenin/alpha catenin 0.017 0.05 -9999.0 0.0 -0.256 14.0 14.0 ITGAE 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.062 0.132 -9999.0 0.0 -0.312 92.0 92.0