Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.015 0.053 -9999.0 0.0 -0.241 14.0 14.0 epithelial cell differentiation 0.017 0.046 -9999.0 0.0 -0.22 14.0 14.0 CYFIP2 0.009 0.05 -9999.0 0.0 -0.417 7.0 7.0 ENAH -0.002 0.097 0.318 19.0 -9999.0 0.0 19.0 EGFR 0.019 0.026 0.188 5.0 -0.417 1.0 6.0 EPHA2 0.018 0.019 -9999.0 0.0 -0.417 1.0 1.0 MYO6 0.016 0.102 0.185 116.0 -0.22 15.0 131.0 CTNNB1 0.014 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.025 0.038 -9999.0 0.0 -0.257 7.0 7.0 AQP5 -0.114 0.195 -9999.0 0.0 -0.423 139.0 139.0 CTNND1 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.018 0.103 0.185 121.0 -0.214 13.0 134.0 regulation of calcium-dependent cell-cell adhesion 0.019 0.104 0.186 120.0 -0.214 15.0 135.0 EGF -0.369 0.136 -9999.0 0.0 -0.417 467.0 467.0 NCKAP1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.031 0.132 -9999.0 0.0 -0.438 38.0 38.0 cortical microtubule organization 0.017 0.046 -9999.0 0.0 -0.22 14.0 14.0 GO:0000145 0.017 0.099 0.176 121.0 -0.205 13.0 134.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.048 -9999.0 0.0 -0.222 14.0 14.0 MLLT4 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.036 0.035 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.045 0.025 -9999.0 0.0 -0.24 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.07 0.282 3.0 -9999.0 0.0 3.0 PVRL2 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.006 0.085 0.172 93.0 -0.216 14.0 107.0 ARF6/GTP 0.046 0.03 -9999.0 0.0 -0.228 2.0 2.0 CDH1 0.005 0.077 -9999.0 0.0 -0.417 17.0 17.0 EGFR/EGFR/EGF/EGF -0.151 0.103 -9999.0 0.0 -0.223 337.0 337.0 RhoA/GDP 0.019 0.045 -9999.0 0.0 -0.213 14.0 14.0 actin cytoskeleton organization 0.009 0.091 0.164 114.0 -0.219 14.0 128.0 IGF-1R heterotetramer 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.021 0.017 0.188 5.0 -9999.0 0.0 5.0 DIAPH1 0.01 0.102 -9999.0 0.0 -0.591 10.0 10.0 Wnt receptor signaling pathway -0.017 0.046 0.22 14.0 -9999.0 0.0 14.0 RHOA 0.014 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.035 0.037 -9999.0 0.0 -0.215 12.0 12.0 CTNNA1 0.015 0.009 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.009 0.092 0.165 114.0 -0.224 14.0 128.0 EFNA1 0.019 0.009 0.188 1.0 -9999.0 0.0 1.0 LPP 0.003 0.086 0.168 93.0 -0.214 12.0 105.0 Ephrin A1/EPHA2 0.012 0.045 -9999.0 0.0 -0.215 14.0 14.0 SEC6/SEC8 -0.033 0.035 -9999.0 0.0 -0.214 13.0 13.0 MGAT3 0.019 0.105 0.188 120.0 -0.217 15.0 135.0 HGF/MET 0.011 0.05 -9999.0 0.0 -0.211 18.0 18.0 HGF 0.014 0.062 0.188 10.0 -0.417 9.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.054 -9999.0 0.0 -0.242 14.0 14.0 actin cable formation 0.033 0.127 0.295 54.0 -0.301 1.0 55.0 KIAA1543 0.013 0.094 0.17 118.0 -0.221 16.0 134.0 KIFC3 0.007 0.085 0.163 106.0 -0.217 15.0 121.0 NCK1 0.018 0.02 -9999.0 0.0 -0.417 1.0 1.0 EXOC3 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.01 0.094 0.18 101.0 -0.218 12.0 113.0 NCK1/GIT1 0.027 0.016 -9999.0 0.0 -0.301 1.0 1.0 mol:GDP 0.017 0.046 -9999.0 0.0 -0.22 14.0 14.0 EXOC4 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.007 0.084 0.163 104.0 -0.216 14.0 118.0 PIP5K1C 0.018 0.104 0.186 121.0 -0.217 13.0 134.0 LIMA1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.005 0.109 0.348 21.0 -9999.0 0.0 21.0 adherens junction assembly 0.025 0.127 0.438 19.0 -0.431 4.0 23.0 IGF-1R heterotetramer/IGF1 0.014 0.043 -9999.0 0.0 -0.215 12.0 12.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.019 0.012 0.188 2.0 -9999.0 0.0 2.0 PLEKHA7 0.013 0.098 0.178 118.0 -0.231 16.0 134.0 mol:GTP 0.043 0.025 -9999.0 0.0 -0.239 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.018 0.127 0.335 50.0 -9999.0 0.0 50.0 cortical actin cytoskeleton stabilization -0.015 0.053 -9999.0 0.0 -0.241 14.0 14.0 regulation of cell-cell adhesion 0.009 0.091 0.164 114.0 -0.219 14.0 128.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.054 -9999.0 0.0 -0.242 14.0 14.0