Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	276.0	21023.0	76.0	-0.045	0.609	1000.0	-1000.0	-0.116	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	257.0	8760.0	34.0	-0.343	0.02	1000.0	-1000.0	-0.03	-1000.0
EGFR-dependent Endothelin signaling events	179.0	3762.0	21.0	-0.369	0.032	1000.0	-1000.0	-0.038	-1000.0
TCR signaling in naïve CD8+ T cells	139.0	13008.0	93.0	-0.236	0.203	1000.0	-1000.0	-0.045	-1000.0
FOXA2 and FOXA3 transcription factor networks	131.0	6040.0	46.0	-0.827	0.022	1000.0	-1000.0	-0.126	-1000.0
IL12-mediated signaling events	114.0	9951.0	87.0	-0.137	0.315	1000.0	-1000.0	-0.096	-1000.0
PDGFR-alpha signaling pathway	113.0	5015.0	44.0	-0.148	0.028	1000.0	-1000.0	-0.034	-1000.0
FOXM1 transcription factor network	87.0	4475.0	51.0	0.019	0.274	1000.0	-1000.0	-0.146	-1000.0
Glypican 1 network	76.0	3666.0	48.0	-0.213	0.093	1000.0	-1000.0	-0.029	-1000.0
BMP receptor signaling	72.0	5857.0	81.0	-0.319	0.039	1000.0	-1000.0	-0.041	-1000.0
TCGA08_p53	68.0	478.0	7.0	-0.066	0.036	1000.0	-1000.0	-0.014	-1000.0
HIF-2-alpha transcription factor network	63.0	2731.0	43.0	-0.25	0.254	1000.0	-1000.0	-0.064	-1000.0
TCGA08_retinoblastoma	63.0	507.0	8.0	-0.048	0.173	1000.0	-1000.0	-0.002	-1000.0
Reelin signaling pathway	59.0	3308.0	56.0	-0.108	0.053	1000.0	-1000.0	-0.038	-1000.0
JNK signaling in the CD4+ TCR pathway	50.0	853.0	17.0	0.018	0.104	1000.0	-1000.0	-0.034	-1000.0
Calcium signaling in the CD4+ TCR pathway	50.0	1575.0	31.0	-0.003	0.19	1000.0	-1000.0	-0.049	-1000.0
amb2 Integrin signaling	47.0	3916.0	82.0	-0.292	0.103	1000.0	-1000.0	-0.037	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	46.0	3463.0	74.0	-0.369	0.046	1000.0	-1000.0	-0.061	-1000.0
IL23-mediated signaling events	45.0	2729.0	60.0	-0.01	0.231	1000.0	-1000.0	-0.136	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	43.0	2365.0	54.0	-0.108	0.141	1000.0	-1000.0	-0.052	-1000.0
Coregulation of Androgen receptor activity	41.0	3170.0	76.0	-0.714	0.17	1000.0	-1000.0	-0.026	-1000.0
Ephrin A  reverse signaling	39.0	275.0	7.0	-0.014	0.021	1000.0	-1000.0	-0.016	-1000.0
Arf6 signaling events	39.0	2472.0	62.0	-0.369	0.084	1000.0	-1000.0	-0.045	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	39.0	2682.0	68.0	-0.192	0.21	1000.0	-1000.0	-0.085	-1000.0
IL27-mediated signaling events	37.0	1928.0	51.0	-0.594	0.321	1000.0	-1000.0	-0.053	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	37.0	1229.0	33.0	-0.12	0.17	1000.0	-1000.0	-0.039	-1000.0
Aurora B signaling	37.0	2512.0	67.0	-0.091	0.132	1000.0	-1000.0	-0.044	-1000.0
Syndecan-1-mediated signaling events	34.0	1179.0	34.0	-0.052	0.094	1000.0	-1000.0	-0.041	-1000.0
Aurora C signaling	34.0	242.0	7.0	-0.0	0.096	1000.0	-1000.0	-0.013	-1000.0
Fc-epsilon receptor I signaling in mast cells	34.0	3335.0	97.0	-0.246	0.104	1000.0	-1000.0	-0.052	-1000.0
Effects of Botulinum toxin	34.0	894.0	26.0	-0.046	0.089	1000.0	-1000.0	-0.01	-1000.0
Noncanonical Wnt signaling pathway	31.0	827.0	26.0	-0.091	0.025	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by STAT5	31.0	700.0	22.0	-0.017	0.107	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by the Hedgehog family	30.0	1580.0	52.0	-0.074	0.094	1000.0	-1000.0	-0.048	-1000.0
IL4-mediated signaling events	30.0	2794.0	91.0	-0.488	0.147	1000.0	-1000.0	-0.171	-1000.0
Ceramide signaling pathway	28.0	2190.0	76.0	-0.369	0.167	1000.0	-1000.0	-0.038	-1000.0
Glypican 2 network	28.0	114.0	4.0	0.032	0.047	1000.0	-1000.0	0.014	-1000.0
IL6-mediated signaling events	28.0	2156.0	75.0	-0.014	0.153	1000.0	-1000.0	-0.073	-1000.0
PLK1 signaling events	27.0	2347.0	85.0	-0.123	0.071	1000.0	-1000.0	-0.026	-1000.0
Wnt signaling	27.0	189.0	7.0	-0.05	0.025	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by PTP1B	24.0	1879.0	76.0	-0.373	0.076	1000.0	-1000.0	-0.039	-1000.0
FoxO family signaling	24.0	1582.0	64.0	-0.54	0.105	1000.0	-1000.0	-0.074	-1000.0
IL2 signaling events mediated by PI3K	23.0	1339.0	58.0	-0.015	0.108	1000.0	-1000.0	-0.048	-1000.0
Integrins in angiogenesis	23.0	1958.0	84.0	-0.167	0.093	1000.0	-1000.0	-0.053	-1000.0
Syndecan-4-mediated signaling events	23.0	1590.0	67.0	-0.187	0.1	1000.0	-1000.0	-0.04	-1000.0
Class I PI3K signaling events	22.0	1650.0	73.0	-0.02	0.113	1000.0	-1000.0	-0.045	-1000.0
Angiopoietin receptor Tie2-mediated signaling	22.0	1985.0	88.0	-0.152	0.061	1000.0	-1000.0	-0.063	-1000.0
Endothelins	21.0	2058.0	96.0	-0.316	0.065	1000.0	-1000.0	-0.05	-1000.0
Thromboxane A2 receptor signaling	20.0	2176.0	105.0	-0.369	0.042	1000.0	-1000.0	-0.048	-1000.0
Syndecan-2-mediated signaling events	20.0	1408.0	69.0	-0.292	0.037	1000.0	-1000.0	-0.029	-1000.0
Signaling mediated by p38-alpha and p38-beta	20.0	880.0	44.0	-0.049	0.025	1000.0	-1000.0	-0.035	-1000.0
LPA receptor mediated events	20.0	2113.0	102.0	-0.072	0.094	1000.0	-1000.0	-0.062	-1000.0
VEGFR1 specific signals	20.0	1154.0	56.0	-0.021	0.107	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	20.0	1591.0	78.0	-0.143	0.07	1000.0	-1000.0	-0.069	-1000.0
Caspase cascade in apoptosis	19.0	1472.0	74.0	-0.261	0.064	1000.0	-1000.0	-0.045	-1000.0
p75(NTR)-mediated signaling	19.0	2376.0	125.0	-0.187	0.072	1000.0	-1000.0	-0.059	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	19.0	866.0	45.0	0.005	0.116	1000.0	-1000.0	-0.054	-1000.0
BCR signaling pathway	19.0	1926.0	99.0	-0.017	0.088	1000.0	-1000.0	-0.053	-1000.0
IFN-gamma pathway	18.0	1241.0	68.0	-0.1	0.09	1000.0	-1000.0	-0.055	-1000.0
Signaling events regulated by Ret tyrosine kinase	18.0	1500.0	82.0	-0.076	0.025	1000.0	-1000.0	-0.053	-1000.0
TCGA08_rtk_signaling	18.0	469.0	26.0	-0.146	0.022	1000.0	-1000.0	-0.031	-1000.0
Regulation of Telomerase	17.0	1734.0	102.0	-0.368	0.095	1000.0	-1000.0	-0.059	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	17.0	2102.0	120.0	-0.068	0.054	1000.0	-1000.0	-0.049	-1000.0
S1P1 pathway	16.0	576.0	36.0	-0.038	0.093	1000.0	-1000.0	-0.045	-1000.0
Nongenotropic Androgen signaling	16.0	858.0	52.0	-0.056	0.037	1000.0	-1000.0	-0.03	-1000.0
E-cadherin signaling in the nascent adherens junction	16.0	1276.0	76.0	-0.069	0.035	1000.0	-1000.0	-0.053	-1000.0
Plasma membrane estrogen receptor signaling	16.0	1384.0	86.0	-0.142	0.058	1000.0	-1000.0	-0.048	-1000.0
Visual signal transduction: Rods	16.0	848.0	52.0	-0.063	0.067	1000.0	-1000.0	-0.047	-1000.0
Presenilin action in Notch and Wnt signaling	15.0	960.0	61.0	-0.09	0.052	1000.0	-1000.0	-0.041	-1000.0
Glucocorticoid receptor regulatory network	15.0	1784.0	114.0	-0.232	0.058	1000.0	-1000.0	-0.068	-1000.0
FAS signaling pathway (CD95)	15.0	741.0	47.0	-0.029	0.1	1000.0	-1000.0	-0.035	-1000.0
E-cadherin signaling in keratinocytes	15.0	667.0	43.0	-0.152	0.02	1000.0	-1000.0	-0.037	-1000.0
Regulation of Androgen receptor activity	15.0	1063.0	70.0	-0.839	0.054	1000.0	-1000.0	-0.051	-1000.0
Aurora A signaling	14.0	855.0	60.0	-0.054	0.067	1000.0	-1000.0	-0.03	-1000.0
IGF1 pathway	14.0	808.0	57.0	-0.104	0.055	1000.0	-1000.0	-0.045	-1000.0
EPO signaling pathway	13.0	760.0	55.0	-0.002	0.072	1000.0	-1000.0	-0.051	-1000.0
PLK2 and PLK4 events	12.0	38.0	3.0	-0.013	-1000.0	1000.0	-1000.0	-0.022	-1000.0
mTOR signaling pathway	12.0	686.0	53.0	-0.053	0.025	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events mediated by Akt	12.0	847.0	68.0	-0.022	0.038	1000.0	-1000.0	-0.04	-1000.0
ceramide signaling pathway	12.0	605.0	49.0	-0.004	0.045	1000.0	-1000.0	-0.044	-1000.0
Canonical Wnt signaling pathway	12.0	635.0	51.0	-0.09	0.064	1000.0	-1000.0	-0.051	-1000.0
PDGFR-beta signaling pathway	12.0	1176.0	97.0	-0.03	0.048	1000.0	-1000.0	-0.052	-1000.0
Regulation of nuclear SMAD2/3 signaling	11.0	1607.0	136.0	-0.189	0.106	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling events	11.0	56.0	5.0	0.005	0.017	1000.0	-1000.0	0.013	-1000.0
ErbB4 signaling events	10.0	757.0	69.0	-0.146	0.104	1000.0	-1000.0	-0.042	-1000.0
Osteopontin-mediated events	10.0	381.0	38.0	-0.037	0.034	1000.0	-1000.0	-0.045	-1000.0
EPHB forward signaling	10.0	882.0	85.0	-0.043	0.049	1000.0	-1000.0	-0.057	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	9.0	813.0	85.0	-0.05	0.043	1000.0	-1000.0	-0.045	-1000.0
Nectin adhesion pathway	9.0	603.0	63.0	-0.035	0.04	1000.0	-1000.0	-0.052	-1000.0
Syndecan-3-mediated signaling events	9.0	347.0	35.0	-0.02	0.052	1000.0	-1000.0	-0.031	-1000.0
ErbB2/ErbB3 signaling events	8.0	548.0	65.0	-0.04	0.035	1000.0	-1000.0	-0.054	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	245.0	28.0	-0.009	0.049	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	8.0	1058.0	125.0	-0.022	0.104	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by PRL	8.0	282.0	34.0	-0.04	0.032	1000.0	-1000.0	-0.037	-1000.0
LPA4-mediated signaling events	7.0	90.0	12.0	-0.022	0.019	1000.0	-1000.0	-0.021	-1000.0
Arf6 downstream pathway	7.0	323.0	43.0	-0.033	0.034	1000.0	-1000.0	-0.028	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	7.0	293.0	37.0	-0.028	0.072	1000.0	-1000.0	-0.035	-1000.0
IL1-mediated signaling events	7.0	484.0	62.0	-0.047	0.041	1000.0	-1000.0	-0.053	-1000.0
Ephrin B reverse signaling	7.0	367.0	48.0	-0.032	0.035	1000.0	-1000.0	-0.033	-1000.0
Arf6 trafficking events	7.0	545.0	71.0	-0.09	0.035	1000.0	-1000.0	-0.033	-1000.0
S1P3 pathway	7.0	307.0	42.0	-0.016	0.094	1000.0	-1000.0	-0.055	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.019	0.019	1000.0	-1000.0	-0.014	-1000.0
S1P5 pathway	6.0	113.0	17.0	-0.004	0.049	1000.0	-1000.0	-0.014	-1000.0
Regulation of p38-alpha and p38-beta	6.0	346.0	54.0	-0.025	0.045	1000.0	-1000.0	-0.047	-1000.0
S1P4 pathway	6.0	174.0	25.0	-0.006	0.049	1000.0	-1000.0	-0.026	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	112.0	17.0	-0.017	0.035	1000.0	-1000.0	-0.033	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	5.0	117.0	23.0	-0.044	0.038	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Cones	5.0	226.0	38.0	-0.018	0.041	1000.0	-1000.0	-0.023	-1000.0
Cellular roles of Anthrax toxin	5.0	206.0	39.0	-0.019	0.026	1000.0	-1000.0	-0.02	-1000.0
Insulin-mediated glucose transport	5.0	181.0	32.0	-0.018	0.038	1000.0	-1000.0	-0.032	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	260.0	52.0	-0.054	0.054	1000.0	-1000.0	-0.051	-1000.0
Insulin Pathway	5.0	417.0	74.0	-0.043	0.055	1000.0	-1000.0	-0.046	-1000.0
p38 MAPK signaling pathway	5.0	247.0	44.0	-0.033	0.041	1000.0	-1000.0	-0.027	-1000.0
Canonical NF-kappaB pathway	4.0	182.0	39.0	-0.019	0.057	1000.0	-1000.0	-0.033	-1000.0
Hedgehog signaling events mediated by Gli proteins	4.0	297.0	65.0	-0.022	0.052	1000.0	-1000.0	-0.051	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	348.0	83.0	-0.025	0.037	1000.0	-1000.0	-0.032	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	61.0	15.0	-0.023	0.02	1000.0	-1000.0	-0.031	-1000.0
BARD1 signaling events	3.0	218.0	57.0	-0.043	0.053	1000.0	-1000.0	-0.035	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	16.0	5.0	0.02	0.032	1000.0	-1000.0	0.01	-1000.0
Signaling events mediated by HDAC Class III	3.0	140.0	40.0	-0.038	0.038	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class I	3.0	325.0	104.0	-0.038	0.052	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	3.0	196.0	58.0	-0.048	0.034	1000.0	-1000.0	-0.044	-1000.0
Atypical NF-kappaB pathway	3.0	107.0	31.0	-0.026	0.025	1000.0	-1000.0	-0.031	-1000.0
Arf1 pathway	3.0	212.0	54.0	-0.013	0.04	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class II	1.0	77.0	75.0	-0.02	0.041	1000.0	-1000.0	-0.031	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	43.0	36.0	-0.038	0.042	1000.0	-1000.0	-0.026	-1000.0
Circadian rhythm pathway	0.0	20.0	22.0	-0.001	0.038	1000.0	-1000.0	-0.038	-1000.0
TRAIL signaling pathway	0.0	43.0	48.0	-0.019	0.047	1000.0	-1000.0	-0.035	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	19.0	27.0	-0.02	0.047	1000.0	-1000.0	-0.036	-1000.0
Rapid glucocorticoid signaling	0.0	12.0	20.0	-0.009	0.025	1000.0	-1000.0	-0.014	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	0.0	0.043	1000.0	-1000.0	0.0	-1000.0
Total	3642	204643	7203	-15.0760381153	-989.789162425	131000	-131000	-5.65081049619	-131000