E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.023 0.149 -9999.0 0.0 -0.445 7.0 7.0 KLHL20 -0.02 0.112 -9999.0 0.0 -0.22 12.0 12.0 CYFIP2 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 Rac1/GDP -0.001 0.111 -9999.0 0.0 -0.277 8.0 8.0 ENAH -0.026 0.151 -9999.0 0.0 -0.445 7.0 7.0 AP1M1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 RAP1A 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 CTNNB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.031 0.083 -9999.0 0.0 -0.359 3.0 3.0 ABI1/Sra1/Nap1 -0.035 0.057 -9999.0 0.0 -0.153 9.0 9.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.011 0.077 -9999.0 0.0 -0.217 7.0 7.0 RAPGEF1 -0.019 0.143 -9999.0 0.0 -0.395 8.0 8.0 CTNND1 -0.009 0.101 -9999.0 0.0 -0.425 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.029 0.154 -9999.0 0.0 -0.462 7.0 7.0 CRK -0.023 0.146 -9999.0 0.0 -0.407 8.0 8.0 E-cadherin/gamma catenin/alpha catenin -0.003 0.094 -9999.0 0.0 -0.273 7.0 7.0 alphaE/beta7 Integrin 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.018 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.021 0.061 -9999.0 0.0 -0.325 2.0 2.0 DLG1 -0.023 0.15 -9999.0 0.0 -0.445 7.0 7.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.066 -9999.0 0.0 -0.268 3.0 3.0 MLLT4 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.02 0.05 -9999.0 0.0 -0.217 3.0 3.0 PI3K -0.039 0.086 -9999.0 0.0 -0.358 3.0 3.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.017 0.108 -9999.0 0.0 -0.33 7.0 7.0 TIAM1 -0.002 0.088 -9999.0 0.0 -0.425 3.0 3.0 E-cadherin(dimer)/Ca2+ -0.003 0.091 -9999.0 0.0 -0.219 10.0 10.0 AKT1 0.005 0.061 -9999.0 0.0 -0.193 3.0 3.0 PIK3R1 -0.016 0.112 -9999.0 0.0 -0.425 5.0 5.0 CDH1 -0.036 0.131 -9999.0 0.0 -0.425 7.0 7.0 RhoA/GDP -0.001 0.115 -9999.0 0.0 -0.279 9.0 9.0 actin cytoskeleton organization -0.012 0.082 -9999.0 0.0 -0.159 12.0 12.0 CDC42/GDP 0.001 0.11 -9999.0 0.0 -0.275 8.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.019 0.106 -9999.0 0.0 -0.261 10.0 10.0 ITGB7 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.002 0.097 -9999.0 0.0 -0.233 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.001 0.069 -9999.0 0.0 -0.203 7.0 7.0 mol:GDP -0.011 0.126 -9999.0 0.0 -0.324 8.0 8.0 CDC42/GTP/IQGAP1 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 p120 catenin/RhoA/GDP -0.005 0.128 -9999.0 0.0 -0.292 10.0 10.0 RAC1/GTP/IQGAP1 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 CDC42 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.027 0.095 -9999.0 0.0 -0.199 16.0 16.0 NME1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.023 0.149 -9999.0 0.0 -0.445 7.0 7.0 regulation of cell-cell adhesion -0.027 0.073 -9999.0 0.0 -0.311 3.0 3.0 WASF2 -0.001 0.041 -9999.0 0.0 -0.102 3.0 3.0 Rap1/GTP -0.001 0.109 -9999.0 0.0 -0.415 3.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.019 0.084 -9999.0 0.0 -0.228 7.0 7.0 CCND1 -0.036 0.117 -9999.0 0.0 -0.248 16.0 16.0 VAV2 -0.016 0.143 -9999.0 0.0 -0.414 7.0 7.0 RAP1/GDP 0.0 0.113 -9999.0 0.0 -0.412 3.0 3.0 adherens junction assembly -0.022 0.145 -9999.0 0.0 -0.43 7.0 7.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.021 0.08 -9999.0 0.0 -0.214 7.0 7.0 E-cadherin/beta catenin -0.02 0.096 -9999.0 0.0 -0.31 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.024 0.15 -9999.0 0.0 -0.446 7.0 7.0 PIK3CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.083 0.146 -9999.0 0.0 -0.313 16.0 16.0 E-cadherin/beta catenin/alpha catenin 0.0 0.081 -9999.0 0.0 -0.24 7.0 7.0 ITGAE 0.015 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.03 0.158 -9999.0 0.0 -0.473 7.0 7.0