Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.067 0.192 -9999.0 0.0 -0.488 12.0 12.0 IHH -0.028 0.079 -9999.0 0.0 -0.527 1.0 1.0 SHH Np/Cholesterol/GAS1 0.015 0.041 -9999.0 0.0 -0.216 2.0 2.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.015 0.041 0.215 2.0 -9999.0 0.0 2.0 SMO/beta Arrestin2 -0.035 0.14 -9999.0 0.0 -0.43 3.0 3.0 SMO -0.045 0.145 -9999.0 0.0 -0.414 4.0 4.0 AKT1 -0.029 0.152 -9999.0 0.0 -0.53 5.0 5.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.004 0.072 -9999.0 0.0 -0.425 2.0 2.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.044 0.143 -9999.0 0.0 -0.408 4.0 4.0 STIL -0.014 0.093 -9999.0 0.0 -0.282 2.0 2.0 DHH N/PTCH2 0.015 0.052 -9999.0 0.0 -0.293 2.0 2.0 DHH N/PTCH1 -0.028 0.114 -9999.0 0.0 -0.257 13.0 13.0 PIK3CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.004 0.072 -9999.0 0.0 -0.425 2.0 2.0 PTHLH -0.137 0.34 -9999.0 0.0 -0.89 12.0 12.0 determination of left/right symmetry -0.044 0.143 -9999.0 0.0 -0.408 4.0 4.0 PIK3R1 -0.016 0.112 -9999.0 0.0 -0.425 5.0 5.0 skeletal system development -0.135 0.335 -9999.0 0.0 -0.879 12.0 12.0 IHH N/Hhip -0.02 0.074 -9999.0 0.0 -0.319 3.0 3.0 DHH N/Hhip -0.002 0.088 -9999.0 0.0 -0.395 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.044 0.143 -9999.0 0.0 -0.408 4.0 4.0 pancreas development -0.01 0.078 -9999.0 0.0 -0.424 2.0 2.0 HHAT 0.008 0.053 -9999.0 0.0 -0.425 1.0 1.0 PI3K 0.001 0.081 -9999.0 0.0 -0.293 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.005 0.055 -9999.0 0.0 -0.425 1.0 1.0 somite specification -0.044 0.143 -9999.0 0.0 -0.408 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.017 0.099 -9999.0 0.0 -0.224 12.0 12.0 SHH Np/Cholesterol/PTCH2 0.02 0.029 -9999.0 0.0 -0.215 1.0 1.0 SHH Np/Cholesterol/Megalin -0.029 0.108 -9999.0 0.0 -0.233 15.0 15.0 SHH 0.015 0.037 -9999.0 0.0 -0.293 1.0 1.0 catabolic process -0.036 0.122 -9999.0 0.0 -0.298 12.0 12.0 SMO/Vitamin D3 -0.029 0.117 -9999.0 0.0 -0.331 4.0 4.0 SHH Np/Cholesterol/Hhip 0.007 0.05 -9999.0 0.0 -0.216 3.0 3.0 LRP2 -0.076 0.179 -9999.0 0.0 -0.425 15.0 15.0 receptor-mediated endocytosis -0.058 0.164 -9999.0 0.0 -0.446 7.0 7.0 SHH Np/Cholesterol/BOC 0.014 0.048 -9999.0 0.0 -0.216 3.0 3.0 SHH Np/Cholesterol/CDO -0.01 0.092 -9999.0 0.0 -0.245 9.0 9.0 mesenchymal cell differentiation -0.007 0.05 0.215 3.0 -9999.0 0.0 3.0 mol:Vitamin D3 -0.016 0.1 -9999.0 0.0 -0.225 12.0 12.0 IHH N/PTCH2 -0.001 0.046 -9999.0 0.0 -0.307 1.0 1.0 CDON -0.041 0.146 -9999.0 0.0 -0.425 9.0 9.0 IHH N/PTCH1 -0.031 0.126 -9999.0 0.0 -0.3 12.0 12.0 Megalin/LRPAP1 -0.042 0.129 -9999.0 0.0 -0.293 15.0 15.0 PTCH2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.011 0.028 -9999.0 0.0 -0.221 1.0 1.0 PTCH1 -0.036 0.122 -9999.0 0.0 -0.299 12.0 12.0 HHIP -0.01 0.079 -9999.0 0.0 -0.425 2.0 2.0