Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.013 0.099 -9999.0 0.0 -0.245 10.0 10.0 epithelial cell differentiation -0.005 0.089 -9999.0 0.0 -0.216 10.0 10.0 CYFIP2 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 ENAH -0.015 0.111 -9999.0 0.0 -0.288 7.0 7.0 EGFR -0.042 0.139 -9999.0 0.0 -0.425 8.0 8.0 EPHA2 -0.004 0.089 -9999.0 0.0 -0.425 3.0 3.0 MYO6 -0.008 0.092 -9999.0 0.0 -0.222 10.0 10.0 CTNNB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.027 0.033 -9999.0 0.0 -0.24 1.0 1.0 AQP5 -0.006 0.13 -9999.0 0.0 -0.555 3.0 3.0 CTNND1 -0.009 0.101 -9999.0 0.0 -0.425 4.0 4.0 mol:PI-4-5-P2 -0.005 0.082 -9999.0 0.0 -0.199 10.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.05 0.13 -9999.0 0.0 -0.241 20.0 20.0 EGF -0.078 0.147 -9999.0 0.0 -0.425 10.0 10.0 NCKAP1 0.013 0.018 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.047 0.204 -9999.0 0.0 -0.587 8.0 8.0 cortical microtubule organization -0.005 0.089 -9999.0 0.0 -0.216 10.0 10.0 GO:0000145 -0.008 0.077 -9999.0 0.0 -0.19 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.002 0.091 -9999.0 0.0 -0.218 10.0 10.0 MLLT4 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 ARF6/GDP -0.06 0.128 -9999.0 0.0 -0.332 10.0 10.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.014 0.137 -9999.0 0.0 -0.309 11.0 11.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.013 0.109 -9999.0 0.0 -0.404 3.0 3.0 PVRL2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.007 0.083 -9999.0 0.0 -0.202 10.0 10.0 ARF6/GTP -0.005 0.129 -9999.0 0.0 -0.282 11.0 11.0 CDH1 -0.036 0.131 -9999.0 0.0 -0.425 7.0 7.0 EGFR/EGFR/EGF/EGF -0.062 0.144 -9999.0 0.0 -0.244 22.0 22.0 RhoA/GDP -0.002 0.087 -9999.0 0.0 -0.199 11.0 11.0 actin cytoskeleton organization -0.005 0.089 -9999.0 0.0 -0.214 10.0 10.0 IGF-1R heterotetramer 0.01 0.052 -9999.0 0.0 -0.424 1.0 1.0 GIT1 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 IGF1R 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 IGF1 -0.02 0.104 -9999.0 0.0 -0.425 4.0 4.0 DIAPH1 0.025 0.071 -9999.0 0.0 -0.545 1.0 1.0 Wnt receptor signaling pathway 0.005 0.089 0.216 10.0 -9999.0 0.0 10.0 RHOA 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 RhoA/GTP -0.062 0.128 -9999.0 0.0 -0.331 10.0 10.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.005 0.091 -9999.0 0.0 -0.218 10.0 10.0 EFNA1 -0.053 0.159 -9999.0 0.0 -0.425 11.0 11.0 LPP -0.024 0.127 -9999.0 0.0 -0.374 5.0 5.0 Ephrin A1/EPHA2 -0.041 0.141 -9999.0 0.0 -0.273 17.0 17.0 SEC6/SEC8 -0.028 0.084 -9999.0 0.0 -0.428 2.0 2.0 MGAT3 -0.051 0.133 -9999.0 0.0 -0.245 20.0 20.0 HGF/MET -0.011 0.087 -9999.0 0.0 -0.288 2.0 2.0 HGF -0.001 0.075 -9999.0 0.0 -0.425 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.013 0.1 -9999.0 0.0 -0.247 10.0 10.0 actin cable formation 0.0 0.108 -9999.0 0.0 -0.267 7.0 7.0 KIAA1543 -0.005 0.081 -9999.0 0.0 -0.187 11.0 11.0 KIFC3 -0.006 0.083 -9999.0 0.0 -0.202 10.0 10.0 NCK1 0.01 0.052 -9999.0 0.0 -0.425 1.0 1.0 EXOC3 0.008 0.053 -9999.0 0.0 -0.425 1.0 1.0 ACTN1 -0.024 0.118 -9999.0 0.0 -0.25 13.0 13.0 NCK1/GIT1 0.016 0.067 -9999.0 0.0 -0.548 1.0 1.0 mol:GDP -0.005 0.089 -9999.0 0.0 -0.216 10.0 10.0 EXOC4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.011 0.1 -9999.0 0.0 -0.243 10.0 10.0 PIP5K1C -0.006 0.083 -9999.0 0.0 -0.202 10.0 10.0 LIMA1 0.002 0.058 -9999.0 0.0 -0.425 1.0 1.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.022 0.127 -9999.0 0.0 -0.344 7.0 7.0 adherens junction assembly 0.008 0.08 -9999.0 0.0 -0.334 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.019 0.102 -9999.0 0.0 -0.22 13.0 13.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0.037 -9999.0 0.0 -0.293 1.0 1.0 MET 0.007 0.054 -9999.0 0.0 -0.425 1.0 1.0 PLEKHA7 -0.006 0.083 -9999.0 0.0 -0.202 10.0 10.0 mol:GTP -0.015 0.136 -9999.0 0.0 -0.307 11.0 11.0 establishment of epithelial cell apical/basal polarity 0.004 0.109 -9999.0 0.0 -0.437 3.0 3.0 cortical actin cytoskeleton stabilization -0.013 0.099 -9999.0 0.0 -0.245 10.0 10.0 regulation of cell-cell adhesion -0.005 0.089 -9999.0 0.0 -0.214 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.013 0.1 -9999.0 0.0 -0.247 10.0 10.0